-- dump date 20140620_022859 -- class Genbank::misc_feature -- table misc_feature_note -- id note 741091000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 741091000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 741091000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091000004 Walker A motif; other site 741091000005 ATP binding site [chemical binding]; other site 741091000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 741091000007 Walker B motif; other site 741091000008 arginine finger; other site 741091000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 741091000010 DnaA box-binding interface [nucleotide binding]; other site 741091000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 741091000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 741091000013 putative DNA binding surface [nucleotide binding]; other site 741091000014 dimer interface [polypeptide binding]; other site 741091000015 beta-clamp/clamp loader binding surface; other site 741091000016 beta-clamp/translesion DNA polymerase binding surface; other site 741091000017 recombination protein F; Reviewed; Region: recF; PRK00064 741091000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091000019 Walker A/P-loop; other site 741091000020 ATP binding site [chemical binding]; other site 741091000021 Q-loop/lid; other site 741091000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091000023 ABC transporter signature motif; other site 741091000024 Walker B; other site 741091000025 D-loop; other site 741091000026 H-loop/switch region; other site 741091000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 741091000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091000029 ATP binding site [chemical binding]; other site 741091000030 Mg2+ binding site [ion binding]; other site 741091000031 G-X-G motif; other site 741091000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 741091000033 anchoring element; other site 741091000034 dimer interface [polypeptide binding]; other site 741091000035 ATP binding site [chemical binding]; other site 741091000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 741091000037 active site 741091000038 putative metal-binding site [ion binding]; other site 741091000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 741091000040 sugar phosphate phosphatase; Provisional; Region: PRK10513 741091000041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091000042 active site 741091000043 motif I; other site 741091000044 motif II; other site 741091000045 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091000046 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 741091000047 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 741091000048 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 741091000049 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 741091000050 putative dimer interface [polypeptide binding]; other site 741091000051 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 741091000052 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 741091000053 putative dimer interface [polypeptide binding]; other site 741091000054 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 741091000055 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091000056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091000057 homodimer interface [polypeptide binding]; other site 741091000058 catalytic residue [active] 741091000059 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 741091000060 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 741091000061 dimerization interface [polypeptide binding]; other site 741091000062 ligand binding site [chemical binding]; other site 741091000063 NADP binding site [chemical binding]; other site 741091000064 catalytic site [active] 741091000065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091000066 D-galactonate transporter; Region: 2A0114; TIGR00893 741091000067 putative substrate translocation pore; other site 741091000068 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 741091000069 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741091000070 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091000071 DNA binding site [nucleotide binding] 741091000072 domain linker motif; other site 741091000073 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 741091000074 putative dimerization interface [polypeptide binding]; other site 741091000075 putative ligand binding site [chemical binding]; other site 741091000076 galactoside permease; Reviewed; Region: lacY; PRK09528 741091000077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091000078 putative substrate translocation pore; other site 741091000079 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 741091000080 Melibiase; Region: Melibiase; pfam02065 741091000081 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741091000082 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091000083 DNA binding site [nucleotide binding] 741091000084 domain linker motif; other site 741091000085 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 741091000086 ligand binding site [chemical binding]; other site 741091000087 putative outer membrane lipoprotein; Provisional; Region: PRK10510 741091000088 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741091000089 ligand binding site [chemical binding]; other site 741091000090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 741091000091 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 741091000092 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 741091000093 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 741091000094 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 741091000095 active site 741091000096 catalytic triad [active] 741091000097 oxyanion hole [active] 741091000098 Autotransporter beta-domain; Region: Autotransporter; cl17461 741091000099 primosomal protein DnaI; Provisional; Region: PRK02854 741091000100 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 741091000101 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 741091000102 dimer interface [polypeptide binding]; other site 741091000103 motif 1; other site 741091000104 active site 741091000105 motif 2; other site 741091000106 motif 3; other site 741091000107 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 741091000108 DALR anticodon binding domain; Region: DALR_1; pfam05746 741091000109 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 741091000110 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 741091000111 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 741091000112 catalytic residues [active] 741091000113 hypothetical protein; Provisional; Region: PRK01184 741091000114 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 741091000115 active site 741091000116 Zn binding site [ion binding]; other site 741091000117 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 741091000118 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 741091000119 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 741091000120 active site 741091000121 P-loop; other site 741091000122 phosphorylation site [posttranslational modification] 741091000123 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741091000124 active site 741091000125 phosphorylation site [posttranslational modification] 741091000126 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 741091000127 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 741091000128 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 741091000129 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 741091000130 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 741091000131 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 741091000132 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 741091000133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091000134 DNA-binding site [nucleotide binding]; DNA binding site 741091000135 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091000136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091000137 homodimer interface [polypeptide binding]; other site 741091000138 catalytic residue [active] 741091000139 hypothetical protein; Provisional; Region: PRK11020 741091000140 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 741091000141 MOSC domain; Region: MOSC; pfam03473 741091000142 3-alpha domain; Region: 3-alpha; pfam03475 741091000143 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 741091000144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091000145 dimerization interface [polypeptide binding]; other site 741091000146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091000147 dimer interface [polypeptide binding]; other site 741091000148 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 741091000149 putative CheW interface [polypeptide binding]; other site 741091000150 superoxide dismutase; Provisional; Region: PRK10925 741091000151 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 741091000152 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 741091000153 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 741091000154 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 741091000155 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 741091000156 [4Fe-4S] binding site [ion binding]; other site 741091000157 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 741091000158 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 741091000159 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 741091000160 molybdopterin cofactor binding site; other site 741091000161 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 741091000162 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 741091000163 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 741091000164 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 741091000165 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 741091000166 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 741091000167 putative glutathione S-transferase; Provisional; Region: PRK10357 741091000168 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 741091000169 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 741091000170 dimer interface [polypeptide binding]; other site 741091000171 N-terminal domain interface [polypeptide binding]; other site 741091000172 putative substrate binding pocket (H-site) [chemical binding]; other site 741091000173 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 741091000174 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 741091000175 NAD(P) binding site [chemical binding]; other site 741091000176 catalytic residues [active] 741091000177 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 741091000178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091000179 putative substrate translocation pore; other site 741091000180 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 741091000181 Acyltransferase family; Region: Acyl_transf_3; pfam01757 741091000182 stationary phase growth adaptation protein; Provisional; Region: PRK09717 741091000183 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 741091000184 conserved cys residue [active] 741091000185 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091000186 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 741091000187 catalytic triad [active] 741091000188 conserved cis-peptide bond; other site 741091000189 DJ-1 family protein; Region: not_thiJ; TIGR01383 741091000190 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 741091000191 conserved cys residue [active] 741091000192 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 741091000193 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 741091000194 putative NAD(P) binding site [chemical binding]; other site 741091000195 catalytic Zn binding site [ion binding]; other site 741091000196 benzoate transporter; Region: benE; TIGR00843 741091000197 Benzoate membrane transport protein; Region: BenE; pfam03594 741091000198 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 741091000199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091000200 non-specific DNA binding site [nucleotide binding]; other site 741091000201 salt bridge; other site 741091000202 sequence-specific DNA binding site [nucleotide binding]; other site 741091000203 Cupin domain; Region: Cupin_2; pfam07883 741091000204 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 741091000205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091000206 Coenzyme A binding pocket [chemical binding]; other site 741091000207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091000208 Coenzyme A binding pocket [chemical binding]; other site 741091000209 glutathione S-transferase; Provisional; Region: PRK15113 741091000210 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 741091000211 C-terminal domain interface [polypeptide binding]; other site 741091000212 GSH binding site (G-site) [chemical binding]; other site 741091000213 dimer interface [polypeptide binding]; other site 741091000214 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 741091000215 N-terminal domain interface [polypeptide binding]; other site 741091000216 putative dimer interface [polypeptide binding]; other site 741091000217 putative substrate binding pocket (H-site) [chemical binding]; other site 741091000218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091000219 Coenzyme A binding pocket [chemical binding]; other site 741091000220 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 741091000221 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 741091000222 hypothetical protein; Provisional; Region: PRK10457 741091000223 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 741091000224 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 741091000225 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 741091000226 Walker A/P-loop; other site 741091000227 ATP binding site [chemical binding]; other site 741091000228 Q-loop/lid; other site 741091000229 ABC transporter signature motif; other site 741091000230 Walker B; other site 741091000231 D-loop; other site 741091000232 H-loop/switch region; other site 741091000233 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 741091000234 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 741091000235 Walker A/P-loop; other site 741091000236 ATP binding site [chemical binding]; other site 741091000237 Q-loop/lid; other site 741091000238 ABC transporter signature motif; other site 741091000239 Walker B; other site 741091000240 D-loop; other site 741091000241 H-loop/switch region; other site 741091000242 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 741091000243 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 741091000244 TM-ABC transporter signature motif; other site 741091000245 HEAT repeats; Region: HEAT_2; pfam13646 741091000246 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 741091000247 TM-ABC transporter signature motif; other site 741091000248 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 741091000249 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 741091000250 putative ligand binding site [chemical binding]; other site 741091000251 Transcriptional regulators [Transcription]; Region: GntR; COG1802 741091000252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091000253 DNA-binding site [nucleotide binding]; DNA binding site 741091000254 FCD domain; Region: FCD; pfam07729 741091000255 urea carboxylase; Region: urea_carbox; TIGR02712 741091000256 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 741091000257 ATP-grasp domain; Region: ATP-grasp_4; cl17255 741091000258 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 741091000259 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 741091000260 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 741091000261 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 741091000262 carboxyltransferase (CT) interaction site; other site 741091000263 biotinylation site [posttranslational modification]; other site 741091000264 allophanate hydrolase; Provisional; Region: PRK08186 741091000265 Amidase; Region: Amidase; cl11426 741091000266 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 741091000267 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 741091000268 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741091000269 MarR family; Region: MarR_2; cl17246 741091000270 Transcriptional regulators [Transcription]; Region: MarR; COG1846 741091000271 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 741091000272 phosphoethanolamine transferase; Provisional; Region: PRK11560 741091000273 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 741091000274 Sulfatase; Region: Sulfatase; pfam00884 741091000275 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 741091000276 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 741091000277 putative regulator PrlF; Provisional; Region: PRK09974 741091000278 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 741091000279 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 741091000280 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091000281 Walker A/P-loop; other site 741091000282 ATP binding site [chemical binding]; other site 741091000283 Q-loop/lid; other site 741091000284 ABC transporter signature motif; other site 741091000285 Walker B; other site 741091000286 D-loop; other site 741091000287 H-loop/switch region; other site 741091000288 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 741091000289 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091000290 Walker A/P-loop; other site 741091000291 ATP binding site [chemical binding]; other site 741091000292 Q-loop/lid; other site 741091000293 ABC transporter signature motif; other site 741091000294 Walker B; other site 741091000295 D-loop; other site 741091000296 H-loop/switch region; other site 741091000297 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091000298 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091000299 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741091000300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091000301 dimer interface [polypeptide binding]; other site 741091000302 conserved gate region; other site 741091000303 putative PBP binding loops; other site 741091000304 ABC-ATPase subunit interface; other site 741091000305 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091000306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091000307 dimer interface [polypeptide binding]; other site 741091000308 conserved gate region; other site 741091000309 putative PBP binding loops; other site 741091000310 ABC-ATPase subunit interface; other site 741091000311 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 741091000312 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 741091000313 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 741091000314 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 741091000315 putative metal binding site [ion binding]; other site 741091000316 cell density-dependent motility repressor; Provisional; Region: PRK10082 741091000317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091000318 LysR substrate binding domain; Region: LysR_substrate; pfam03466 741091000319 dimerization interface [polypeptide binding]; other site 741091000320 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091000321 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 741091000322 peptide binding site [polypeptide binding]; other site 741091000323 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091000324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091000325 dimer interface [polypeptide binding]; other site 741091000326 conserved gate region; other site 741091000327 putative PBP binding loops; other site 741091000328 ABC-ATPase subunit interface; other site 741091000329 dipeptide transporter; Provisional; Region: PRK10913 741091000330 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741091000331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091000332 dimer interface [polypeptide binding]; other site 741091000333 conserved gate region; other site 741091000334 putative PBP binding loops; other site 741091000335 ABC-ATPase subunit interface; other site 741091000336 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 741091000337 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091000338 Walker A/P-loop; other site 741091000339 ATP binding site [chemical binding]; other site 741091000340 Q-loop/lid; other site 741091000341 ABC transporter signature motif; other site 741091000342 Walker B; other site 741091000343 D-loop; other site 741091000344 H-loop/switch region; other site 741091000345 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 741091000346 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 741091000347 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091000348 Walker A/P-loop; other site 741091000349 ATP binding site [chemical binding]; other site 741091000350 Q-loop/lid; other site 741091000351 ABC transporter signature motif; other site 741091000352 Walker B; other site 741091000353 D-loop; other site 741091000354 H-loop/switch region; other site 741091000355 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 741091000356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 741091000357 Transposase; Region: DEDD_Tnp_IS110; pfam01548 741091000358 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 741091000359 mobile mystery protein B; Region: mob_myst_B; TIGR02613 741091000360 Fic/DOC family; Region: Fic; pfam02661 741091000361 mobile mystery protein A; Region: mob_myst_A; TIGR02612 741091000362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091000363 non-specific DNA binding site [nucleotide binding]; other site 741091000364 salt bridge; other site 741091000365 sequence-specific DNA binding site [nucleotide binding]; other site 741091000366 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 741091000367 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 741091000368 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 741091000369 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 741091000370 cellulose synthase regulator protein; Provisional; Region: PRK11114 741091000371 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 741091000372 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 741091000373 DXD motif; other site 741091000374 PilZ domain; Region: PilZ; pfam07238 741091000375 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 741091000376 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 741091000377 P-loop; other site 741091000378 Magnesium ion binding site [ion binding]; other site 741091000379 putative diguanylate cyclase; Provisional; Region: PRK13561 741091000380 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091000381 metal binding site [ion binding]; metal-binding site 741091000382 active site 741091000383 I-site; other site 741091000384 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091000385 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 741091000386 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 741091000387 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 741091000388 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 741091000389 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 741091000390 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741091000391 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 741091000392 substrate binding site [chemical binding]; other site 741091000393 ATP binding site [chemical binding]; other site 741091000394 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 741091000395 active site 1 [active] 741091000396 dimer interface [polypeptide binding]; other site 741091000397 hexamer interface [polypeptide binding]; other site 741091000398 active site 2 [active] 741091000399 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091000400 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 741091000401 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 741091000402 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 741091000403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091000404 metabolite-proton symporter; Region: 2A0106; TIGR00883 741091000405 putative substrate translocation pore; other site 741091000406 inner membrane protein YhjD; Region: TIGR00766 741091000407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091000408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091000409 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 741091000410 putative effector binding pocket; other site 741091000411 putative dimerization interface [polypeptide binding]; other site 741091000412 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 741091000413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091000414 NAD(P) binding site [chemical binding]; other site 741091000415 active site 741091000416 Flagellar regulator YcgR; Region: YcgR; pfam07317 741091000417 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 741091000418 PilZ domain; Region: PilZ; pfam07238 741091000419 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 741091000420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741091000421 binding surface 741091000422 TPR motif; other site 741091000423 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 741091000424 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741091000425 DNA binding residues [nucleotide binding] 741091000426 malate:quinone oxidoreductase; Validated; Region: PRK05257 741091000427 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 741091000428 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 741091000429 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 741091000430 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 741091000431 malate:quinone oxidoreductase; Validated; Region: PRK05257 741091000432 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 741091000433 inner membrane transporter YjeM; Provisional; Region: PRK15238 741091000434 Domain of unknown function (DUF386); Region: DUF386; cl01047 741091000435 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 741091000436 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 741091000437 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 741091000438 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 741091000439 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 741091000440 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 741091000441 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091000442 DNA binding site [nucleotide binding] 741091000443 domain linker motif; other site 741091000444 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 741091000445 putative dimerization interface [polypeptide binding]; other site 741091000446 putative ligand binding site [chemical binding]; other site 741091000447 alpha-glucosidase; Provisional; Region: PRK10137 741091000448 Protein of unknown function, DUF608; Region: DUF608; pfam04685 741091000449 Trehalase; Region: Trehalase; cl17346 741091000450 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 741091000451 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 741091000452 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 741091000453 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 741091000454 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 741091000455 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 741091000456 active site 741091000457 Zn binding site [ion binding]; other site 741091000458 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 741091000459 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 741091000460 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 741091000461 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 741091000462 DNA binding site [nucleotide binding] 741091000463 active site 741091000464 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 741091000465 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 741091000466 tetramer interface [polypeptide binding]; other site 741091000467 active site 741091000468 Mg2+/Mn2+ binding site [ion binding]; other site 741091000469 putative transporter; Provisional; Region: PRK10054 741091000470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091000471 putative substrate translocation pore; other site 741091000472 Uncharacterized conserved protein [Function unknown]; Region: COG4748 741091000473 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 741091000474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091000475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091000476 putative transporter; Provisional; Region: PRK10504 741091000477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091000478 putative substrate translocation pore; other site 741091000479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091000480 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 741091000481 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741091000482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091000483 Walker A/P-loop; other site 741091000484 ATP binding site [chemical binding]; other site 741091000485 Q-loop/lid; other site 741091000486 ABC transporter signature motif; other site 741091000487 Walker B; other site 741091000488 D-loop; other site 741091000489 H-loop/switch region; other site 741091000490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 741091000491 Protein of unknown function, DUF482; Region: DUF482; pfam04339 741091000492 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 741091000493 active site clefts [active] 741091000494 zinc binding site [ion binding]; other site 741091000495 dimer interface [polypeptide binding]; other site 741091000496 methionine sulfoxide reductase A; Provisional; Region: PRK14054 741091000497 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 741091000498 active site 1 [active] 741091000499 dimer interface [polypeptide binding]; other site 741091000500 hexamer interface [polypeptide binding]; other site 741091000501 active site 2 [active] 741091000502 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 741091000503 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 741091000504 active site 741091000505 P-loop; other site 741091000506 phosphorylation site [posttranslational modification] 741091000507 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741091000508 active site 741091000509 phosphorylation site [posttranslational modification] 741091000510 AAA domain; Region: AAA_17; pfam13207 741091000511 Class I aldolases; Region: Aldolase_Class_I; cl17187 741091000512 catalytic residue [active] 741091000513 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 741091000514 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741091000515 DNA binding residues [nucleotide binding] 741091000516 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 741091000517 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 741091000518 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 741091000519 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 741091000520 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 741091000521 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741091000522 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741091000523 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 741091000524 Isochorismatase family; Region: Isochorismatase; pfam00857 741091000525 catalytic triad [active] 741091000526 dimer interface [polypeptide binding]; other site 741091000527 conserved cis-peptide bond; other site 741091000528 Predicted membrane protein [Function unknown]; Region: COG2259 741091000529 Transmembrane secretion effector; Region: MFS_3; pfam05977 741091000530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091000531 putative substrate translocation pore; other site 741091000532 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 741091000533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091000534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091000535 dimerization interface [polypeptide binding]; other site 741091000536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 741091000537 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 741091000538 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 741091000539 GIY-YIG motif/motif A; other site 741091000540 active site 741091000541 catalytic site [active] 741091000542 putative DNA binding site [nucleotide binding]; other site 741091000543 metal binding site [ion binding]; metal-binding site 741091000544 glutathione reductase; Validated; Region: PRK06116 741091000545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741091000546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741091000547 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 741091000548 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 741091000549 oligopeptidase A; Provisional; Region: PRK10911 741091000550 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 741091000551 active site 741091000552 Zn binding site [ion binding]; other site 741091000553 putative methyltransferase; Provisional; Region: PRK10742 741091000554 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 741091000555 Ligand Binding Site [chemical binding]; other site 741091000556 universal stress protein UspB; Provisional; Region: PRK04960 741091000557 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 741091000558 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 741091000559 Predicted flavoproteins [General function prediction only]; Region: COG2081 741091000560 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741091000561 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 741091000562 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091000563 dimer interface [polypeptide binding]; other site 741091000564 putative CheW interface [polypeptide binding]; other site 741091000565 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 741091000566 Beta-lactamase; Region: Beta-lactamase; pfam00144 741091000567 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 741091000568 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 741091000569 putative acyl-acceptor binding pocket; other site 741091000570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 741091000571 major facilitator superfamily transporter; Provisional; Region: PRK05122 741091000572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091000573 putative substrate translocation pore; other site 741091000574 putative acetyltransferase YhhY; Provisional; Region: PRK10140 741091000575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091000576 Coenzyme A binding pocket [chemical binding]; other site 741091000577 Pirin-related protein [General function prediction only]; Region: COG1741 741091000578 Pirin; Region: Pirin; pfam02678 741091000579 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 741091000580 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741091000581 Autotransporter beta-domain; Region: Autotransporter; smart00869 741091000582 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 741091000583 active site 741091000584 P-loop; other site 741091000585 phosphorylation site [posttranslational modification] 741091000586 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 741091000587 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 741091000588 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 741091000589 beta-galactosidase; Region: BGL; TIGR03356 741091000590 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741091000591 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091000592 DNA binding site [nucleotide binding] 741091000593 domain linker motif; other site 741091000594 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 741091000595 ligand binding site [chemical binding]; other site 741091000596 dimerization interface [polypeptide binding]; other site 741091000597 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 741091000598 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091000599 DNA binding site [nucleotide binding] 741091000600 domain linker motif; other site 741091000601 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 741091000602 putative ligand binding site [chemical binding]; other site 741091000603 putative dimerization interface [polypeptide binding]; other site 741091000604 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 741091000605 ATP-binding site [chemical binding]; other site 741091000606 Gluconate-6-phosphate binding site [chemical binding]; other site 741091000607 Shikimate kinase; Region: SKI; pfam01202 741091000608 high-affinity gluconate transporter; Provisional; Region: PRK14984 741091000609 gluconate transporter; Region: gntP; TIGR00791 741091000610 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 741091000611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091000612 non-specific DNA binding site [nucleotide binding]; other site 741091000613 salt bridge; other site 741091000614 sequence-specific DNA binding site [nucleotide binding]; other site 741091000615 putative antibiotic transporter; Provisional; Region: PRK10739 741091000616 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 741091000617 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 741091000618 glycogen branching enzyme; Provisional; Region: PRK05402 741091000619 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 741091000620 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 741091000621 active site 741091000622 catalytic site [active] 741091000623 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 741091000624 glycogen debranching enzyme; Provisional; Region: PRK03705 741091000625 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 741091000626 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 741091000627 active site 741091000628 catalytic site [active] 741091000629 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 741091000630 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 741091000631 ligand binding site; other site 741091000632 oligomer interface; other site 741091000633 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 741091000634 dimer interface [polypeptide binding]; other site 741091000635 N-terminal domain interface [polypeptide binding]; other site 741091000636 sulfate 1 binding site; other site 741091000637 glycogen synthase; Provisional; Region: glgA; PRK00654 741091000638 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 741091000639 ADP-binding pocket [chemical binding]; other site 741091000640 homodimer interface [polypeptide binding]; other site 741091000641 glycogen phosphorylase; Provisional; Region: PRK14986 741091000642 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 741091000643 homodimer interface [polypeptide binding]; other site 741091000644 active site pocket [active] 741091000645 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 741091000646 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 741091000647 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 741091000648 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741091000649 intramembrane serine protease GlpG; Provisional; Region: PRK10907 741091000650 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 741091000651 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 741091000652 HipA-like N-terminal domain; Region: HipA_N; pfam07805 741091000653 HipA-like C-terminal domain; Region: HipA_C; pfam07804 741091000654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 741091000655 sequence-specific DNA binding site [nucleotide binding]; other site 741091000656 salt bridge; other site 741091000657 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 741091000658 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 741091000659 homodimer interface [polypeptide binding]; other site 741091000660 substrate-cofactor binding pocket; other site 741091000661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091000662 catalytic residue [active] 741091000663 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 741091000664 active site residue [active] 741091000665 transcriptional repressor UlaR; Provisional; Region: PRK13509 741091000666 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 741091000667 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741091000668 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 741091000669 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 741091000670 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 741091000671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 741091000672 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 741091000673 active site 741091000674 P-loop; other site 741091000675 phosphorylation site [posttranslational modification] 741091000676 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741091000677 active site 741091000678 phosphorylation site [posttranslational modification] 741091000679 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 741091000680 active site 741091000681 dimer interface [polypeptide binding]; other site 741091000682 magnesium binding site [ion binding]; other site 741091000683 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 741091000684 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 741091000685 AP (apurinic/apyrimidinic) site pocket; other site 741091000686 DNA interaction; other site 741091000687 Metal-binding active site; metal-binding site 741091000688 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 741091000689 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 741091000690 intersubunit interface [polypeptide binding]; other site 741091000691 active site 741091000692 Zn2+ binding site [ion binding]; other site 741091000693 maltodextrin phosphorylase; Provisional; Region: PRK14985 741091000694 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 741091000695 active site pocket [active] 741091000696 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 741091000697 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 741091000698 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 741091000699 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 741091000700 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 741091000701 DNA utilization protein GntX; Provisional; Region: PRK11595 741091000702 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741091000703 active site 741091000704 carboxylesterase BioH; Provisional; Region: PRK10349 741091000705 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741091000706 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 741091000707 Coenzyme A transferase; Region: CoA_trans; cl17247 741091000708 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 741091000709 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 741091000710 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 741091000711 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 741091000712 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 741091000713 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 741091000714 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 741091000715 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 741091000716 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 741091000717 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 741091000718 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 741091000719 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091000720 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091000721 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 741091000722 putative dimerization interface [polypeptide binding]; other site 741091000723 FeoC like transcriptional regulator; Region: FeoC; cl17677 741091000724 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 741091000725 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 741091000726 G1 box; other site 741091000727 GTP/Mg2+ binding site [chemical binding]; other site 741091000728 Switch I region; other site 741091000729 G2 box; other site 741091000730 G3 box; other site 741091000731 Switch II region; other site 741091000732 G4 box; other site 741091000733 G5 box; other site 741091000734 Nucleoside recognition; Region: Gate; pfam07670 741091000735 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 741091000736 Nucleoside recognition; Region: Gate; pfam07670 741091000737 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 741091000738 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 741091000739 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 741091000740 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 741091000741 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 741091000742 RNA binding site [nucleotide binding]; other site 741091000743 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 741091000744 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 741091000745 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 741091000746 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 741091000747 MG2 domain; Region: A2M_N; pfam01835 741091000748 Alpha-2-macroglobulin family; Region: A2M; pfam00207 741091000749 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 741091000750 surface patch; other site 741091000751 thioester region; other site 741091000752 specificity defining residues; other site 741091000753 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 741091000754 Transglycosylase; Region: Transgly; pfam00912 741091000755 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 741091000756 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 741091000757 Fimbrial protein; Region: Fimbrial; cl01416 741091000758 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 741091000759 PapC N-terminal domain; Region: PapC_N; pfam13954 741091000760 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741091000761 PapC C-terminal domain; Region: PapC_C; pfam13953 741091000762 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 741091000763 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741091000764 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741091000765 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741091000766 osmolarity response regulator; Provisional; Region: ompR; PRK09468 741091000767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091000768 active site 741091000769 phosphorylation site [posttranslational modification] 741091000770 intermolecular recognition site; other site 741091000771 dimerization interface [polypeptide binding]; other site 741091000772 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091000773 DNA binding site [nucleotide binding] 741091000774 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 741091000775 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091000776 dimerization interface [polypeptide binding]; other site 741091000777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091000778 dimer interface [polypeptide binding]; other site 741091000779 phosphorylation site [posttranslational modification] 741091000780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091000781 ATP binding site [chemical binding]; other site 741091000782 G-X-G motif; other site 741091000783 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 741091000784 oligomeric interface; other site 741091000785 putative active site [active] 741091000786 homodimer interface [polypeptide binding]; other site 741091000787 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 741091000788 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 741091000789 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 741091000790 active site 741091000791 substrate-binding site [chemical binding]; other site 741091000792 metal-binding site [ion binding] 741091000793 ATP binding site [chemical binding]; other site 741091000794 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 741091000795 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 741091000796 dimerization interface [polypeptide binding]; other site 741091000797 domain crossover interface; other site 741091000798 redox-dependent activation switch; other site 741091000799 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741091000800 RNA binding surface [nucleotide binding]; other site 741091000801 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 741091000802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091000803 motif II; other site 741091000804 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 741091000805 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 741091000806 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 741091000807 ADP-ribose binding site [chemical binding]; other site 741091000808 dimer interface [polypeptide binding]; other site 741091000809 active site 741091000810 nudix motif; other site 741091000811 metal binding site [ion binding]; metal-binding site 741091000812 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 741091000813 Transglycosylase; Region: Transgly; pfam00912 741091000814 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 741091000815 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 741091000816 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 741091000817 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 741091000818 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 741091000819 Secretin and TonB N terminus short domain; Region: STN; pfam07660 741091000820 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 741091000821 shikimate kinase; Reviewed; Region: aroK; PRK00131 741091000822 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 741091000823 ADP binding site [chemical binding]; other site 741091000824 magnesium binding site [ion binding]; other site 741091000825 putative shikimate binding site; other site 741091000826 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 741091000827 active site 741091000828 dimer interface [polypeptide binding]; other site 741091000829 metal binding site [ion binding]; metal-binding site 741091000830 hypothetical protein; Reviewed; Region: PRK11901 741091000831 cell division protein DamX; Validated; Region: PRK10905 741091000832 DNA adenine methylase; Provisional; Region: PRK10904 741091000833 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 741091000834 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 741091000835 substrate binding site [chemical binding]; other site 741091000836 hexamer interface [polypeptide binding]; other site 741091000837 metal binding site [ion binding]; metal-binding site 741091000838 phosphoglycolate phosphatase; Provisional; Region: PRK13222 741091000839 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091000840 motif II; other site 741091000841 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 741091000842 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 741091000843 active site 741091000844 HIGH motif; other site 741091000845 dimer interface [polypeptide binding]; other site 741091000846 KMSKS motif; other site 741091000847 siroheme synthase; Provisional; Region: cysG; PRK10637 741091000848 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 741091000849 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 741091000850 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 741091000851 active site 741091000852 SAM binding site [chemical binding]; other site 741091000853 homodimer interface [polypeptide binding]; other site 741091000854 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 741091000855 nitrite reductase subunit NirD; Provisional; Region: PRK14989 741091000856 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741091000857 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 741091000858 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 741091000859 cytosine deaminase; Provisional; Region: PRK09230 741091000860 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 741091000861 active site 741091000862 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 741091000863 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 741091000864 substrate binding site [chemical binding]; other site 741091000865 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 741091000866 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 741091000867 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 741091000868 active site 741091000869 catalytic residues [active] 741091000870 Protein of unknown function (DUF2559); Region: DUF2559; cl08097 741091000871 Fic/DOC family; Region: Fic; cl00960 741091000872 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 741091000873 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 741091000874 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 741091000875 glutamine binding [chemical binding]; other site 741091000876 catalytic triad [active] 741091000877 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 741091000878 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741091000879 inhibitor-cofactor binding pocket; inhibition site 741091000880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091000881 catalytic residue [active] 741091000882 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 741091000883 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 741091000884 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 741091000885 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 741091000886 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 741091000887 ligand binding site [chemical binding]; other site 741091000888 flexible hinge region; other site 741091000889 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 741091000890 putative switch regulator; other site 741091000891 non-specific DNA interactions [nucleotide binding]; other site 741091000892 DNA binding site [nucleotide binding] 741091000893 sequence specific DNA binding site [nucleotide binding]; other site 741091000894 putative cAMP binding site [chemical binding]; other site 741091000895 hypothetical protein; Provisional; Region: PRK10738 741091000896 phosphoribulokinase; Provisional; Region: PRK15453 741091000897 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 741091000898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091000899 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091000900 dimerization interface [polypeptide binding]; other site 741091000901 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 741091000902 ureidoglycolate hydrolase; Provisional; Region: PRK03606 741091000903 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 741091000904 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 741091000905 Bacterial transcriptional regulator; Region: IclR; pfam01614 741091000906 glyoxylate carboligase; Provisional; Region: PRK11269 741091000907 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 741091000908 PYR/PP interface [polypeptide binding]; other site 741091000909 dimer interface [polypeptide binding]; other site 741091000910 TPP binding site [chemical binding]; other site 741091000911 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 741091000912 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 741091000913 TPP-binding site [chemical binding]; other site 741091000914 hydroxypyruvate isomerase; Provisional; Region: PRK09997 741091000915 tartronate semialdehyde reductase; Provisional; Region: PRK15059 741091000916 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 741091000917 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 741091000918 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 741091000919 Na binding site [ion binding]; other site 741091000920 putative substrate binding site [chemical binding]; other site 741091000921 allantoinase; Provisional; Region: PRK08044 741091000922 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 741091000923 active site 741091000924 putative uracil/xanthine transporter; Provisional; Region: PRK11412 741091000925 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 741091000926 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 741091000927 Cupin domain; Region: Cupin_2; cl17218 741091000928 Cupin domain; Region: Cupin_2; cl17218 741091000929 allantoate amidohydrolase; Region: AllC; TIGR03176 741091000930 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 741091000931 active site 741091000932 metal binding site [ion binding]; metal-binding site 741091000933 dimer interface [polypeptide binding]; other site 741091000934 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 741091000935 membrane protein FdrA; Validated; Region: PRK06091 741091000936 CoA binding domain; Region: CoA_binding; pfam02629 741091000937 CoA-ligase; Region: Ligase_CoA; pfam00549 741091000938 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 741091000939 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 741091000940 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 741091000941 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 741091000942 putative substrate binding site [chemical binding]; other site 741091000943 nucleotide binding site [chemical binding]; other site 741091000944 nucleotide binding site [chemical binding]; other site 741091000945 homodimer interface [polypeptide binding]; other site 741091000946 hypothetical protein; Provisional; Region: PRK04966 741091000947 putative hydrolase; Provisional; Region: PRK10985 741091000948 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 741091000949 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 741091000950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091000951 Walker A/P-loop; other site 741091000952 ATP binding site [chemical binding]; other site 741091000953 Q-loop/lid; other site 741091000954 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091000955 ABC transporter signature motif; other site 741091000956 Walker B; other site 741091000957 D-loop; other site 741091000958 ABC transporter; Region: ABC_tran_2; pfam12848 741091000959 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091000960 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 741091000961 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 741091000962 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 741091000963 TrkA-N domain; Region: TrkA_N; pfam02254 741091000964 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 741091000965 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 741091000966 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 741091000967 phi X174 lysis protein; Provisional; Region: PRK02793 741091000968 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 741091000969 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 741091000970 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 741091000971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 741091000972 YheO-like PAS domain; Region: PAS_6; pfam08348 741091000973 HTH domain; Region: HTH_22; pfam13309 741091000974 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 741091000975 sulfur relay protein TusC; Validated; Region: PRK00211 741091000976 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 741091000977 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 741091000978 S17 interaction site [polypeptide binding]; other site 741091000979 S8 interaction site; other site 741091000980 16S rRNA interaction site [nucleotide binding]; other site 741091000981 streptomycin interaction site [chemical binding]; other site 741091000982 23S rRNA interaction site [nucleotide binding]; other site 741091000983 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 741091000984 30S ribosomal protein S7; Validated; Region: PRK05302 741091000985 elongation factor G; Reviewed; Region: PRK00007 741091000986 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 741091000987 G1 box; other site 741091000988 putative GEF interaction site [polypeptide binding]; other site 741091000989 GTP/Mg2+ binding site [chemical binding]; other site 741091000990 Switch I region; other site 741091000991 G2 box; other site 741091000992 G3 box; other site 741091000993 Switch II region; other site 741091000994 G4 box; other site 741091000995 G5 box; other site 741091000996 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 741091000997 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 741091000998 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 741091000999 elongation factor Tu; Reviewed; Region: PRK00049 741091001000 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 741091001001 G1 box; other site 741091001002 GEF interaction site [polypeptide binding]; other site 741091001003 GTP/Mg2+ binding site [chemical binding]; other site 741091001004 Switch I region; other site 741091001005 G2 box; other site 741091001006 G3 box; other site 741091001007 Switch II region; other site 741091001008 G4 box; other site 741091001009 G5 box; other site 741091001010 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 741091001011 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 741091001012 Antibiotic Binding Site [chemical binding]; other site 741091001013 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 741091001014 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 741091001015 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 741091001016 heme binding site [chemical binding]; other site 741091001017 ferroxidase pore; other site 741091001018 ferroxidase diiron center [ion binding]; other site 741091001019 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 741091001020 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 741091001021 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 741091001022 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 741091001023 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 741091001024 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 741091001025 GspL periplasmic domain; Region: GspL_C; pfam12693 741091001026 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 741091001027 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 741091001028 type II secretion system protein J; Region: gspJ; TIGR01711 741091001029 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 741091001030 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 741091001031 type II secretion system protein I; Region: gspI; TIGR01707 741091001032 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 741091001033 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 741091001034 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 741091001035 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 741091001036 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 741091001037 type II secretion system protein F; Region: GspF; TIGR02120 741091001038 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 741091001039 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 741091001040 type II secretion system protein E; Region: type_II_gspE; TIGR02533 741091001041 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 741091001042 Walker A motif; other site 741091001043 ATP binding site [chemical binding]; other site 741091001044 Walker B motif; other site 741091001045 type II secretion system protein D; Region: type_II_gspD; TIGR02517 741091001046 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 741091001047 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 741091001048 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 741091001049 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 741091001050 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 741091001051 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 741091001052 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 741091001053 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 741091001054 AAA ATPase domain; Region: AAA_16; pfam13191 741091001055 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 741091001056 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 741091001057 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 741091001058 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 741091001059 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 741091001060 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 741091001061 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 741091001062 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 741091001063 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 741091001064 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 741091001065 protein-rRNA interface [nucleotide binding]; other site 741091001066 putative translocon binding site; other site 741091001067 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 741091001068 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 741091001069 G-X-X-G motif; other site 741091001070 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 741091001071 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 741091001072 23S rRNA interface [nucleotide binding]; other site 741091001073 5S rRNA interface [nucleotide binding]; other site 741091001074 putative antibiotic binding site [chemical binding]; other site 741091001075 L25 interface [polypeptide binding]; other site 741091001076 L27 interface [polypeptide binding]; other site 741091001077 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 741091001078 23S rRNA interface [nucleotide binding]; other site 741091001079 putative translocon interaction site; other site 741091001080 signal recognition particle (SRP54) interaction site; other site 741091001081 L23 interface [polypeptide binding]; other site 741091001082 trigger factor interaction site; other site 741091001083 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 741091001084 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 741091001085 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 741091001086 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 741091001087 RNA binding site [nucleotide binding]; other site 741091001088 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 741091001089 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 741091001090 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 741091001091 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 741091001092 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 741091001093 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 741091001094 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 741091001095 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 741091001096 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 741091001097 23S rRNA interface [nucleotide binding]; other site 741091001098 5S rRNA interface [nucleotide binding]; other site 741091001099 L27 interface [polypeptide binding]; other site 741091001100 L5 interface [polypeptide binding]; other site 741091001101 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 741091001102 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 741091001103 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 741091001104 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 741091001105 23S rRNA binding site [nucleotide binding]; other site 741091001106 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 741091001107 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 741091001108 SecY translocase; Region: SecY; pfam00344 741091001109 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 741091001110 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 741091001111 30S ribosomal protein S13; Region: bact_S13; TIGR03631 741091001112 30S ribosomal protein S11; Validated; Region: PRK05309 741091001113 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 741091001114 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 741091001115 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741091001116 RNA binding surface [nucleotide binding]; other site 741091001117 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 741091001118 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 741091001119 alphaNTD homodimer interface [polypeptide binding]; other site 741091001120 alphaNTD - beta interaction site [polypeptide binding]; other site 741091001121 alphaNTD - beta' interaction site [polypeptide binding]; other site 741091001122 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 741091001123 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 741091001124 hypothetical protein; Provisional; Region: PRK10203 741091001125 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 741091001126 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 741091001127 DNA binding residues [nucleotide binding] 741091001128 dimer interface [polypeptide binding]; other site 741091001129 metal binding site [ion binding]; metal-binding site 741091001130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 741091001131 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 741091001132 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 741091001133 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 741091001134 TrkA-N domain; Region: TrkA_N; pfam02254 741091001135 TrkA-C domain; Region: TrkA_C; pfam02080 741091001136 TrkA-N domain; Region: TrkA_N; pfam02254 741091001137 TrkA-C domain; Region: TrkA_C; pfam02080 741091001138 16S rRNA methyltransferase B; Provisional; Region: PRK10901 741091001139 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 741091001140 putative RNA binding site [nucleotide binding]; other site 741091001141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091001142 S-adenosylmethionine binding site [chemical binding]; other site 741091001143 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 741091001144 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 741091001145 putative active site [active] 741091001146 substrate binding site [chemical binding]; other site 741091001147 putative cosubstrate binding site; other site 741091001148 catalytic site [active] 741091001149 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 741091001150 substrate binding site [chemical binding]; other site 741091001151 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 741091001152 active site 741091001153 catalytic residues [active] 741091001154 metal binding site [ion binding]; metal-binding site 741091001155 hypothetical protein; Provisional; Region: PRK10736 741091001156 DNA protecting protein DprA; Region: dprA; TIGR00732 741091001157 hypothetical protein; Validated; Region: PRK03430 741091001158 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 741091001159 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 741091001160 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 741091001161 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 741091001162 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 741091001163 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 741091001164 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 741091001165 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 741091001166 shikimate binding site; other site 741091001167 NAD(P) binding site [chemical binding]; other site 741091001168 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 741091001169 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 741091001170 trimer interface [polypeptide binding]; other site 741091001171 putative metal binding site [ion binding]; other site 741091001172 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 741091001173 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 741091001174 Na binding site [ion binding]; other site 741091001175 Predicted membrane protein [Function unknown]; Region: COG3162 741091001176 acetyl-CoA synthetase; Provisional; Region: PRK00174 741091001177 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 741091001178 active site 741091001179 CoA binding site [chemical binding]; other site 741091001180 acyl-activating enzyme (AAE) consensus motif; other site 741091001181 AMP binding site [chemical binding]; other site 741091001182 acetate binding site [chemical binding]; other site 741091001183 Fimbrial protein; Region: Fimbrial; cl01416 741091001184 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 741091001185 PapC N-terminal domain; Region: PapC_N; pfam13954 741091001186 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741091001187 PapC C-terminal domain; Region: PapC_C; pfam13953 741091001188 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 741091001189 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741091001190 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741091001191 Fimbrial protein; Region: Fimbrial; pfam00419 741091001192 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091001193 non-specific DNA binding site [nucleotide binding]; other site 741091001194 salt bridge; other site 741091001195 sequence-specific DNA binding site [nucleotide binding]; other site 741091001196 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 741091001197 DNA binding site [nucleotide binding] 741091001198 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 741091001199 putative dimer interface [polypeptide binding]; other site 741091001200 catalytic triad [active] 741091001201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091001202 D-galactonate transporter; Region: 2A0114; TIGR00893 741091001203 putative substrate translocation pore; other site 741091001204 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 741091001205 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 741091001206 active site pocket [active] 741091001207 putative transcriptional regulator; Provisional; Region: PRK11640 741091001208 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 741091001209 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 741091001210 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 741091001211 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 741091001212 DsbD alpha interface [polypeptide binding]; other site 741091001213 catalytic residues [active] 741091001214 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 741091001215 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 741091001216 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 741091001217 Aspartase; Region: Aspartase; cd01357 741091001218 active sites [active] 741091001219 tetramer interface [polypeptide binding]; other site 741091001220 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 741091001221 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 741091001222 oligomerisation interface [polypeptide binding]; other site 741091001223 mobile loop; other site 741091001224 roof hairpin; other site 741091001225 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 741091001226 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 741091001227 ring oligomerisation interface [polypeptide binding]; other site 741091001228 ATP/Mg binding site [chemical binding]; other site 741091001229 stacking interactions; other site 741091001230 hinge regions; other site 741091001231 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 741091001232 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 741091001233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091001234 FeS/SAM binding site; other site 741091001235 elongation factor P; Validated; Region: PRK00529 741091001236 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 741091001237 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 741091001238 RNA binding site [nucleotide binding]; other site 741091001239 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 741091001240 RNA binding site [nucleotide binding]; other site 741091001241 Predicted small secreted protein [Function unknown]; Region: COG5510 741091001242 Entericidin EcnA/B family; Region: Entericidin; cl02322 741091001243 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 741091001244 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 741091001245 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 741091001246 Iron-sulfur protein interface; other site 741091001247 proximal quinone binding site [chemical binding]; other site 741091001248 C-subunit interface; other site 741091001249 distal quinone binding site; other site 741091001250 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 741091001251 D-subunit interface [polypeptide binding]; other site 741091001252 Iron-sulfur protein interface; other site 741091001253 proximal quinone binding site [chemical binding]; other site 741091001254 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 741091001255 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741091001256 catalytic loop [active] 741091001257 iron binding site [ion binding]; other site 741091001258 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 741091001259 L-aspartate oxidase; Provisional; Region: PRK06175 741091001260 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 741091001261 poxB regulator PoxA; Provisional; Region: PRK09350 741091001262 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 741091001263 motif 1; other site 741091001264 dimer interface [polypeptide binding]; other site 741091001265 active site 741091001266 motif 2; other site 741091001267 motif 3; other site 741091001268 xanthine permease; Region: pbuX; TIGR03173 741091001269 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 741091001270 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 741091001271 active site 741091001272 putative substrate binding pocket [chemical binding]; other site 741091001273 putative mechanosensitive channel protein; Provisional; Region: PRK10929 741091001274 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 741091001275 Mechanosensitive ion channel; Region: MS_channel; pfam00924 741091001276 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 741091001277 GTPase RsgA; Reviewed; Region: PRK12288 741091001278 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 741091001279 RNA binding site [nucleotide binding]; other site 741091001280 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 741091001281 GTPase/Zn-binding domain interface [polypeptide binding]; other site 741091001282 GTP/Mg2+ binding site [chemical binding]; other site 741091001283 G4 box; other site 741091001284 G5 box; other site 741091001285 G1 box; other site 741091001286 Switch I region; other site 741091001287 G2 box; other site 741091001288 G3 box; other site 741091001289 Switch II region; other site 741091001290 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 741091001291 catalytic site [active] 741091001292 putative active site [active] 741091001293 putative substrate binding site [chemical binding]; other site 741091001294 dimer interface [polypeptide binding]; other site 741091001295 epoxyqueuosine reductase; Region: TIGR00276 741091001296 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 741091001297 putative carbohydrate kinase; Provisional; Region: PRK10565 741091001298 Uncharacterized conserved protein [Function unknown]; Region: COG0062 741091001299 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 741091001300 putative substrate binding site [chemical binding]; other site 741091001301 putative ATP binding site [chemical binding]; other site 741091001302 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 741091001303 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 741091001304 AMIN domain; Region: AMIN; pfam11741 741091001305 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 741091001306 active site 741091001307 metal binding site [ion binding]; metal-binding site 741091001308 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741091001309 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741091001310 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 741091001311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091001312 ATP binding site [chemical binding]; other site 741091001313 Mg2+ binding site [ion binding]; other site 741091001314 G-X-G motif; other site 741091001315 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 741091001316 ATP binding site [chemical binding]; other site 741091001317 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 741091001318 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 741091001319 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 741091001320 bacterial Hfq-like; Region: Hfq; cd01716 741091001321 hexamer interface [polypeptide binding]; other site 741091001322 Sm1 motif; other site 741091001323 RNA binding site [nucleotide binding]; other site 741091001324 Sm2 motif; other site 741091001325 GTPase HflX; Provisional; Region: PRK11058 741091001326 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 741091001327 HflX GTPase family; Region: HflX; cd01878 741091001328 G1 box; other site 741091001329 GTP/Mg2+ binding site [chemical binding]; other site 741091001330 Switch I region; other site 741091001331 G2 box; other site 741091001332 G3 box; other site 741091001333 Switch II region; other site 741091001334 G4 box; other site 741091001335 G5 box; other site 741091001336 FtsH protease regulator HflK; Provisional; Region: PRK10930 741091001337 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 741091001338 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 741091001339 FtsH protease regulator HflC; Provisional; Region: PRK11029 741091001340 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 741091001341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 741091001342 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 741091001343 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 741091001344 GDP-binding site [chemical binding]; other site 741091001345 ACT binding site; other site 741091001346 IMP binding site; other site 741091001347 transcriptional repressor NsrR; Provisional; Region: PRK11014 741091001348 Rrf2 family protein; Region: rrf2_super; TIGR00738 741091001349 exoribonuclease R; Provisional; Region: PRK11642 741091001350 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 741091001351 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 741091001352 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 741091001353 RNB domain; Region: RNB; pfam00773 741091001354 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 741091001355 RNA binding site [nucleotide binding]; other site 741091001356 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 741091001357 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 741091001358 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 741091001359 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 741091001360 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 741091001361 FAD binding site [chemical binding]; other site 741091001362 substrate binding site [chemical binding]; other site 741091001363 catalytic residues [active] 741091001364 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 741091001365 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091001366 dimerization interface [polypeptide binding]; other site 741091001367 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 741091001368 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091001369 dimer interface [polypeptide binding]; other site 741091001370 putative CheW interface [polypeptide binding]; other site 741091001371 esterase; Provisional; Region: PRK10566 741091001372 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741091001373 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 741091001374 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 741091001375 dimer interface [polypeptide binding]; other site 741091001376 ssDNA binding site [nucleotide binding]; other site 741091001377 tetramer (dimer of dimers) interface [polypeptide binding]; other site 741091001378 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 741091001379 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 741091001380 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 741091001381 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 741091001382 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 741091001383 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 741091001384 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 741091001385 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 741091001386 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 741091001387 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 741091001388 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 741091001389 Hemerythrin-like domain; Region: Hr-like; cd12108 741091001390 Fe binding site [ion binding]; other site 741091001391 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 741091001392 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 741091001393 active site 741091001394 metal binding site [ion binding]; metal-binding site 741091001395 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 741091001396 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 741091001397 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 741091001398 active site 741091001399 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 741091001400 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 741091001401 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 741091001402 Domain of unknown function DUF21; Region: DUF21; pfam01595 741091001403 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 741091001404 Transporter associated domain; Region: CorC_HlyC; smart01091 741091001405 methionine sulfoxide reductase A; Provisional; Region: PRK00058 741091001406 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 741091001407 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741091001408 Surface antigen; Region: Bac_surface_Ag; pfam01103 741091001409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 741091001410 Family of unknown function (DUF490); Region: DUF490; pfam04357 741091001411 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 741091001412 putative active site pocket [active] 741091001413 dimerization interface [polypeptide binding]; other site 741091001414 putative catalytic residue [active] 741091001415 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 741091001416 dimer interface [polypeptide binding]; other site 741091001417 substrate binding site [chemical binding]; other site 741091001418 metal binding sites [ion binding]; metal-binding site 741091001419 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 741091001420 dimer interface [polypeptide binding]; other site 741091001421 ligand binding site [chemical binding]; other site 741091001422 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 741091001423 HAMP domain; Region: HAMP; pfam00672 741091001424 dimerization interface [polypeptide binding]; other site 741091001425 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091001426 dimer interface [polypeptide binding]; other site 741091001427 putative CheW interface [polypeptide binding]; other site 741091001428 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 741091001429 AMP binding site [chemical binding]; other site 741091001430 metal binding site [ion binding]; metal-binding site 741091001431 active site 741091001432 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 741091001433 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 741091001434 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 741091001435 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 741091001436 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741091001437 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741091001438 arginine repressor; Provisional; Region: PRK05066 741091001439 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 741091001440 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 741091001441 malate dehydrogenase; Provisional; Region: PRK05086 741091001442 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 741091001443 NAD binding site [chemical binding]; other site 741091001444 dimerization interface [polypeptide binding]; other site 741091001445 Substrate binding site [chemical binding]; other site 741091001446 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 741091001447 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 741091001448 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 741091001449 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 741091001450 substrate binding pocket [chemical binding]; other site 741091001451 chain length determination region; other site 741091001452 substrate-Mg2+ binding site; other site 741091001453 catalytic residues [active] 741091001454 aspartate-rich region 1; other site 741091001455 active site lid residues [active] 741091001456 aspartate-rich region 2; other site 741091001457 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 741091001458 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 741091001459 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 741091001460 EamA-like transporter family; Region: EamA; pfam00892 741091001461 GTPase CgtA; Reviewed; Region: obgE; PRK12298 741091001462 GTP1/OBG; Region: GTP1_OBG; pfam01018 741091001463 Obg GTPase; Region: Obg; cd01898 741091001464 G1 box; other site 741091001465 GTP/Mg2+ binding site [chemical binding]; other site 741091001466 Switch I region; other site 741091001467 G2 box; other site 741091001468 G3 box; other site 741091001469 Switch II region; other site 741091001470 G4 box; other site 741091001471 G5 box; other site 741091001472 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 741091001473 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741091001474 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 741091001475 sensor protein BasS/PmrB; Provisional; Region: PRK10755 741091001476 HAMP domain; Region: HAMP; pfam00672 741091001477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091001478 dimer interface [polypeptide binding]; other site 741091001479 phosphorylation site [posttranslational modification] 741091001480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091001481 ATP binding site [chemical binding]; other site 741091001482 Mg2+ binding site [ion binding]; other site 741091001483 G-X-G motif; other site 741091001484 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 741091001485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091001486 active site 741091001487 phosphorylation site [posttranslational modification] 741091001488 intermolecular recognition site; other site 741091001489 dimerization interface [polypeptide binding]; other site 741091001490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091001491 DNA binding site [nucleotide binding] 741091001492 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 741091001493 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 741091001494 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 741091001495 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 741091001496 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 741091001497 RNA-binding protein YhbY; Provisional; Region: PRK10343 741091001498 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 741091001499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091001500 S-adenosylmethionine binding site [chemical binding]; other site 741091001501 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 741091001502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091001503 Walker A motif; other site 741091001504 ATP binding site [chemical binding]; other site 741091001505 Walker B motif; other site 741091001506 arginine finger; other site 741091001507 Peptidase family M41; Region: Peptidase_M41; pfam01434 741091001508 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 741091001509 dihydropteroate synthase; Region: DHPS; TIGR01496 741091001510 substrate binding pocket [chemical binding]; other site 741091001511 dimer interface [polypeptide binding]; other site 741091001512 inhibitor binding site; inhibition site 741091001513 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 741091001514 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 741091001515 active site 741091001516 substrate binding site [chemical binding]; other site 741091001517 metal binding site [ion binding]; metal-binding site 741091001518 Preprotein translocase SecG subunit; Region: SecG; pfam03840 741091001519 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 741091001520 NusA N-terminal domain; Region: NusA_N; pfam08529 741091001521 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 741091001522 RNA binding site [nucleotide binding]; other site 741091001523 homodimer interface [polypeptide binding]; other site 741091001524 NusA-like KH domain; Region: KH_5; pfam13184 741091001525 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 741091001526 G-X-X-G motif; other site 741091001527 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 741091001528 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 741091001529 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 741091001530 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 741091001531 translation initiation factor IF-2; Validated; Region: infB; PRK05306 741091001532 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 741091001533 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 741091001534 G1 box; other site 741091001535 putative GEF interaction site [polypeptide binding]; other site 741091001536 GTP/Mg2+ binding site [chemical binding]; other site 741091001537 Switch I region; other site 741091001538 G2 box; other site 741091001539 G3 box; other site 741091001540 Switch II region; other site 741091001541 G4 box; other site 741091001542 G5 box; other site 741091001543 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 741091001544 Translation-initiation factor 2; Region: IF-2; pfam11987 741091001545 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 741091001546 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 741091001547 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 741091001548 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 741091001549 RNA binding site [nucleotide binding]; other site 741091001550 active site 741091001551 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 741091001552 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 741091001553 16S/18S rRNA binding site [nucleotide binding]; other site 741091001554 S13e-L30e interaction site [polypeptide binding]; other site 741091001555 25S rRNA binding site [nucleotide binding]; other site 741091001556 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 741091001557 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 741091001558 RNase E interface [polypeptide binding]; other site 741091001559 trimer interface [polypeptide binding]; other site 741091001560 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 741091001561 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 741091001562 RNase E interface [polypeptide binding]; other site 741091001563 trimer interface [polypeptide binding]; other site 741091001564 active site 741091001565 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 741091001566 putative nucleic acid binding region [nucleotide binding]; other site 741091001567 G-X-X-G motif; other site 741091001568 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 741091001569 RNA binding site [nucleotide binding]; other site 741091001570 domain interface; other site 741091001571 lipoprotein NlpI; Provisional; Region: PRK11189 741091001572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741091001573 binding surface 741091001574 TPR motif; other site 741091001575 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 741091001576 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 741091001577 ATP binding site [chemical binding]; other site 741091001578 Mg++ binding site [ion binding]; other site 741091001579 motif III; other site 741091001580 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091001581 nucleotide binding region [chemical binding]; other site 741091001582 ATP-binding site [chemical binding]; other site 741091001583 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 741091001584 putative RNA binding site [nucleotide binding]; other site 741091001585 hypothetical protein; Provisional; Region: PRK10508 741091001586 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 741091001587 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 741091001588 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 741091001589 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091001590 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091001591 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 741091001592 ABC-2 type transporter; Region: ABC2_membrane; cl17235 741091001593 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 741091001594 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 741091001595 putative protease; Provisional; Region: PRK15447 741091001596 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 741091001597 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 741091001598 Peptidase family U32; Region: Peptidase_U32; pfam01136 741091001599 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 741091001600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091001601 Coenzyme A binding pocket [chemical binding]; other site 741091001602 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 741091001603 GIY-YIG motif/motif A; other site 741091001604 putative active site [active] 741091001605 putative metal binding site [ion binding]; other site 741091001606 hypothetical protein; Provisional; Region: PRK03467 741091001607 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 741091001608 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 741091001609 NAD binding site [chemical binding]; other site 741091001610 active site 741091001611 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 741091001612 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 741091001613 trimer interface [polypeptide binding]; other site 741091001614 active site 741091001615 substrate binding site [chemical binding]; other site 741091001616 CoA binding site [chemical binding]; other site 741091001617 Guanylate kinase; Region: Guanylate_kin; pfam00625 741091001618 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 741091001619 active site 741091001620 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 741091001621 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 741091001622 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 741091001623 active site 741091001624 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 741091001625 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 741091001626 Walker A/P-loop; other site 741091001627 ATP binding site [chemical binding]; other site 741091001628 Q-loop/lid; other site 741091001629 ABC transporter signature motif; other site 741091001630 Walker B; other site 741091001631 D-loop; other site 741091001632 H-loop/switch region; other site 741091001633 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 741091001634 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091001635 Walker A/P-loop; other site 741091001636 ATP binding site [chemical binding]; other site 741091001637 Q-loop/lid; other site 741091001638 ABC transporter signature motif; other site 741091001639 Walker B; other site 741091001640 D-loop; other site 741091001641 H-loop/switch region; other site 741091001642 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091001643 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 741091001644 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 741091001645 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 741091001646 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 741091001647 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 741091001648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091001649 DNA-binding site [nucleotide binding]; DNA binding site 741091001650 UTRA domain; Region: UTRA; pfam07702 741091001651 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 741091001652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091001653 non-specific DNA binding site [nucleotide binding]; other site 741091001654 salt bridge; other site 741091001655 sequence-specific DNA binding site [nucleotide binding]; other site 741091001656 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 741091001657 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 741091001658 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 741091001659 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 741091001660 ATP cone domain; Region: ATP-cone; pfam03477 741091001661 Class III ribonucleotide reductase; Region: RNR_III; cd01675 741091001662 effector binding site; other site 741091001663 active site 741091001664 Zn binding site [ion binding]; other site 741091001665 glycine loop; other site 741091001666 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 741091001667 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 741091001668 Ca binding site [ion binding]; other site 741091001669 active site 741091001670 catalytic site [active] 741091001671 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 741091001672 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 741091001673 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741091001674 active site turn [active] 741091001675 phosphorylation site [posttranslational modification] 741091001676 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741091001677 trehalose repressor; Provisional; Region: treR; PRK09492 741091001678 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091001679 DNA binding site [nucleotide binding] 741091001680 domain linker motif; other site 741091001681 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 741091001682 dimerization interface [polypeptide binding]; other site 741091001683 ligand binding site [chemical binding]; other site 741091001684 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 741091001685 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 741091001686 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 741091001687 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 741091001688 Soluble P-type ATPase [General function prediction only]; Region: COG4087 741091001689 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 741091001690 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 741091001691 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 741091001692 catalytic triad [active] 741091001693 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 741091001694 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741091001695 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 741091001696 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 741091001697 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 741091001698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091001699 S-adenosylmethionine binding site [chemical binding]; other site 741091001700 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 741091001701 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 741091001702 active site 741091001703 FMN binding site [chemical binding]; other site 741091001704 2,4-decadienoyl-CoA binding site; other site 741091001705 catalytic residue [active] 741091001706 4Fe-4S cluster binding site [ion binding]; other site 741091001707 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 741091001708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741091001709 enoyl-CoA hydratase; Validated; Region: PRK08788 741091001710 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 741091001711 substrate binding site [chemical binding]; other site 741091001712 oxyanion hole (OAH) forming residues; other site 741091001713 trimer interface [polypeptide binding]; other site 741091001714 RNase II stability modulator; Provisional; Region: PRK10060 741091001715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091001716 putative active site [active] 741091001717 heme pocket [chemical binding]; other site 741091001718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091001719 metal binding site [ion binding]; metal-binding site 741091001720 active site 741091001721 I-site; other site 741091001722 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091001723 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 741091001724 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 741091001725 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 741091001726 transcriptional regulator MalT; Provisional; Region: PRK04841 741091001727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741091001728 DNA binding residues [nucleotide binding] 741091001729 dimerization interface [polypeptide binding]; other site 741091001730 maltodextrin phosphorylase; Provisional; Region: PRK14985 741091001731 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 741091001732 active site pocket [active] 741091001733 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 741091001734 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 741091001735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 741091001736 Transposase; Region: DEDD_Tnp_IS110; pfam01548 741091001737 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 741091001738 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741091001739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091001740 dimer interface [polypeptide binding]; other site 741091001741 conserved gate region; other site 741091001742 putative PBP binding loops; other site 741091001743 ABC-ATPase subunit interface; other site 741091001744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091001745 dimer interface [polypeptide binding]; other site 741091001746 conserved gate region; other site 741091001747 putative PBP binding loops; other site 741091001748 ABC-ATPase subunit interface; other site 741091001749 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 741091001750 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 741091001751 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 741091001752 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 741091001753 Walker A/P-loop; other site 741091001754 ATP binding site [chemical binding]; other site 741091001755 Q-loop/lid; other site 741091001756 ABC transporter signature motif; other site 741091001757 Walker B; other site 741091001758 D-loop; other site 741091001759 H-loop/switch region; other site 741091001760 TOBE domain; Region: TOBE_2; pfam08402 741091001761 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 741091001762 trimer interface; other site 741091001763 sugar binding site [chemical binding]; other site 741091001764 maltose regulon periplasmic protein; Provisional; Region: PRK10564 741091001765 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 741091001766 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091001767 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091001768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091001769 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 741091001770 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 741091001771 active site 741091001772 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 741091001773 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 741091001774 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 741091001775 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 741091001776 DNA binding site [nucleotide binding] 741091001777 active site 741091001778 glutamate dehydrogenase; Provisional; Region: PRK09414 741091001779 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 741091001780 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 741091001781 NAD(P) binding site [chemical binding]; other site 741091001782 outer membrane receptor FepA; Provisional; Region: PRK13524 741091001783 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741091001784 N-terminal plug; other site 741091001785 ligand-binding site [chemical binding]; other site 741091001786 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 741091001787 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 741091001788 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 741091001789 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 741091001790 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 741091001791 Walker A/P-loop; other site 741091001792 ATP binding site [chemical binding]; other site 741091001793 Q-loop/lid; other site 741091001794 ABC transporter signature motif; other site 741091001795 Walker B; other site 741091001796 D-loop; other site 741091001797 H-loop/switch region; other site 741091001798 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 741091001799 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741091001800 ABC-ATPase subunit interface; other site 741091001801 dimer interface [polypeptide binding]; other site 741091001802 putative PBP binding regions; other site 741091001803 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 741091001804 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 741091001805 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741091001806 ABC-ATPase subunit interface; other site 741091001807 dimer interface [polypeptide binding]; other site 741091001808 putative PBP binding regions; other site 741091001809 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 741091001810 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 741091001811 siderophore binding site; other site 741091001812 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741091001813 active site 741091001814 DNA binding site [nucleotide binding] 741091001815 Int/Topo IB signature motif; other site 741091001816 PAAR motif; Region: PAAR_motif; pfam05488 741091001817 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 741091001818 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 741091001819 integrase; Provisional; Region: int; PHA02601 741091001820 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741091001821 active site 741091001822 DNA binding site [nucleotide binding] 741091001823 Int/Topo IB signature motif; other site 741091001824 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 741091001825 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 741091001826 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 741091001827 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 741091001828 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 741091001829 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 741091001830 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 741091001831 portal vertex protein; Provisional; Region: Q; PHA02536 741091001832 Phage portal protein; Region: Phage_portal; pfam04860 741091001833 terminase ATPase subunit; Provisional; Region: P; PHA02535 741091001834 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 741091001835 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 741091001836 capsid protein; Provisional; Region: N; PHA02538 741091001837 terminase endonuclease subunit; Provisional; Region: M; PHA02537 741091001838 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 741091001839 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 741091001840 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 741091001841 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 741091001842 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741091001843 catalytic residues [active] 741091001844 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 741091001845 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 741091001846 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 741091001847 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 741091001848 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 741091001849 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 741091001850 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 741091001851 baseplate assembly protein; Provisional; Region: J; PHA02568 741091001852 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 741091001853 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 741091001854 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 741091001855 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 741091001856 major tail sheath protein; Provisional; Region: FI; PHA02560 741091001857 major tail tube protein; Provisional; Region: FII; PHA02600 741091001858 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 741091001859 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 741091001860 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 741091001861 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 741091001862 tail protein; Provisional; Region: D; PHA02561 741091001863 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 741091001864 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 741091001865 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 741091001866 active site 741091001867 SUMO-1 interface [polypeptide binding]; other site 741091001868 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 741091001869 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 741091001870 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 741091001871 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 741091001872 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 741091001873 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 741091001874 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741091001875 DNA binding residues [nucleotide binding] 741091001876 DNA primase; Validated; Region: dnaG; PRK05667 741091001877 CHC2 zinc finger; Region: zf-CHC2; pfam01807 741091001878 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 741091001879 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 741091001880 active site 741091001881 metal binding site [ion binding]; metal-binding site 741091001882 interdomain interaction site; other site 741091001883 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 741091001884 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 741091001885 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 741091001886 UGMP family protein; Validated; Region: PRK09604 741091001887 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 741091001888 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 741091001889 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 741091001890 homooctamer interface [polypeptide binding]; other site 741091001891 active site 741091001892 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 741091001893 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 741091001894 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 741091001895 active site 741091001896 NTP binding site [chemical binding]; other site 741091001897 metal binding triad [ion binding]; metal-binding site 741091001898 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 741091001899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 741091001900 Zn2+ binding site [ion binding]; other site 741091001901 Mg2+ binding site [ion binding]; other site 741091001902 SH3 domain-containing protein; Provisional; Region: PRK10884 741091001903 Bacterial SH3 domain homologues; Region: SH3b; smart00287 741091001904 Uncharacterized conserved protein [Function unknown]; Region: COG3025 741091001905 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 741091001906 putative active site [active] 741091001907 putative metal binding residues [ion binding]; other site 741091001908 signature motif; other site 741091001909 putative triphosphate binding site [ion binding]; other site 741091001910 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 741091001911 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 741091001912 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 741091001913 metal binding triad; other site 741091001914 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 741091001915 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 741091001916 metal binding triad; other site 741091001917 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 741091001918 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 741091001919 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 741091001920 putative ribose interaction site [chemical binding]; other site 741091001921 putative ADP binding site [chemical binding]; other site 741091001922 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 741091001923 active site 741091001924 nucleotide binding site [chemical binding]; other site 741091001925 HIGH motif; other site 741091001926 KMSKS motif; other site 741091001927 putative transporter; Provisional; Region: PRK11021 741091001928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 741091001929 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 741091001930 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 741091001931 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 741091001932 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 741091001933 putative active site [active] 741091001934 metal binding site [ion binding]; metal-binding site 741091001935 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 741091001936 hypothetical protein; Provisional; Region: PRK11653 741091001937 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 741091001938 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 741091001939 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 741091001940 dimer interface [polypeptide binding]; other site 741091001941 ADP-ribose binding site [chemical binding]; other site 741091001942 active site 741091001943 nudix motif; other site 741091001944 metal binding site [ion binding]; metal-binding site 741091001945 putative dehydrogenase; Provisional; Region: PRK11039 741091001946 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 741091001947 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741091001948 active site 741091001949 metal binding site [ion binding]; metal-binding site 741091001950 hexamer interface [polypeptide binding]; other site 741091001951 esterase YqiA; Provisional; Region: PRK11071 741091001952 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 741091001953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091001954 ATP binding site [chemical binding]; other site 741091001955 Mg2+ binding site [ion binding]; other site 741091001956 G-X-G motif; other site 741091001957 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 741091001958 anchoring element; other site 741091001959 dimer interface [polypeptide binding]; other site 741091001960 ATP binding site [chemical binding]; other site 741091001961 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 741091001962 active site 741091001963 metal binding site [ion binding]; metal-binding site 741091001964 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 741091001965 Uncharacterized conserved protein [Function unknown]; Region: COG1359 741091001966 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 741091001967 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 741091001968 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 741091001969 CAP-like domain; other site 741091001970 active site 741091001971 primary dimer interface [polypeptide binding]; other site 741091001972 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 741091001973 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 741091001974 putative acyl-acceptor binding pocket; other site 741091001975 FtsI repressor; Provisional; Region: PRK10883 741091001976 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 741091001977 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 741091001978 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091001979 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091001980 active site 741091001981 catalytic tetrad [active] 741091001982 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 741091001983 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 741091001984 putative NAD(P) binding site [chemical binding]; other site 741091001985 putative substrate binding site [chemical binding]; other site 741091001986 catalytic Zn binding site [ion binding]; other site 741091001987 structural Zn binding site [ion binding]; other site 741091001988 dimer interface [polypeptide binding]; other site 741091001989 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 741091001990 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 741091001991 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091001992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091001993 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 741091001994 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 741091001995 cystathionine beta-lyase; Provisional; Region: PRK08114 741091001996 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 741091001997 homodimer interface [polypeptide binding]; other site 741091001998 substrate-cofactor binding pocket; other site 741091001999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091002000 catalytic residue [active] 741091002001 DctM-like transporters; Region: DctM; pfam06808 741091002002 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 741091002003 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 741091002004 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 741091002005 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 741091002006 biopolymer transport protein ExbB; Provisional; Region: PRK10414 741091002007 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 741091002008 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 741091002009 galactarate dehydratase; Region: galactar-dH20; TIGR03248 741091002010 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 741091002011 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 741091002012 D-galactonate transporter; Region: 2A0114; TIGR00893 741091002013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091002014 putative substrate translocation pore; other site 741091002015 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 741091002016 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 741091002017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 741091002018 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 741091002019 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 741091002020 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 741091002021 dimer interface [polypeptide binding]; other site 741091002022 active site 741091002023 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 741091002024 substrate binding site [chemical binding]; other site 741091002025 catalytic residue [active] 741091002026 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 741091002027 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 741091002028 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091002029 dimerization interface [polypeptide binding]; other site 741091002030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091002031 dimer interface [polypeptide binding]; other site 741091002032 phosphorylation site [posttranslational modification] 741091002033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091002034 ATP binding site [chemical binding]; other site 741091002035 Mg2+ binding site [ion binding]; other site 741091002036 G-X-G motif; other site 741091002037 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 741091002038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091002039 active site 741091002040 phosphorylation site [posttranslational modification] 741091002041 intermolecular recognition site; other site 741091002042 dimerization interface [polypeptide binding]; other site 741091002043 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 741091002044 putative binding surface; other site 741091002045 active site 741091002046 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 741091002047 TRAM domain; Region: TRAM; pfam01938 741091002048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091002049 S-adenosylmethionine binding site [chemical binding]; other site 741091002050 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 741091002051 HD domain; Region: HD_4; pfam13328 741091002052 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 741091002053 synthetase active site [active] 741091002054 NTP binding site [chemical binding]; other site 741091002055 metal binding site [ion binding]; metal-binding site 741091002056 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 741091002057 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 741091002058 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 741091002059 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 741091002060 homodimer interface [polypeptide binding]; other site 741091002061 metal binding site [ion binding]; metal-binding site 741091002062 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 741091002063 homodimer interface [polypeptide binding]; other site 741091002064 active site 741091002065 putative chemical substrate binding site [chemical binding]; other site 741091002066 metal binding site [ion binding]; metal-binding site 741091002067 CTP synthetase; Validated; Region: pyrG; PRK05380 741091002068 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 741091002069 Catalytic site [active] 741091002070 active site 741091002071 UTP binding site [chemical binding]; other site 741091002072 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 741091002073 active site 741091002074 putative oxyanion hole; other site 741091002075 catalytic triad [active] 741091002076 enolase; Provisional; Region: eno; PRK00077 741091002077 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 741091002078 dimer interface [polypeptide binding]; other site 741091002079 metal binding site [ion binding]; metal-binding site 741091002080 substrate binding pocket [chemical binding]; other site 741091002081 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 741091002082 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741091002083 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 741091002084 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741091002085 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 741091002086 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 741091002087 putative active site [active] 741091002088 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 741091002089 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741091002090 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741091002091 active site turn [active] 741091002092 phosphorylation site [posttranslational modification] 741091002093 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 741091002094 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 741091002095 putative active site cavity [active] 741091002096 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 741091002097 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 741091002098 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 741091002099 active site 741091002100 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 741091002101 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 741091002102 Flavodoxin; Region: Flavodoxin_1; pfam00258 741091002103 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 741091002104 FAD binding pocket [chemical binding]; other site 741091002105 FAD binding motif [chemical binding]; other site 741091002106 catalytic residues [active] 741091002107 NAD binding pocket [chemical binding]; other site 741091002108 phosphate binding motif [ion binding]; other site 741091002109 beta-alpha-beta structure motif; other site 741091002110 sulfite reductase subunit beta; Provisional; Region: PRK13504 741091002111 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 741091002112 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 741091002113 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 741091002114 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 741091002115 Active Sites [active] 741091002116 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 741091002117 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 741091002118 metal binding site [ion binding]; metal-binding site 741091002119 siroheme synthase; Provisional; Region: cysG; PRK10637 741091002120 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 741091002121 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 741091002122 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 741091002123 active site 741091002124 SAM binding site [chemical binding]; other site 741091002125 homodimer interface [polypeptide binding]; other site 741091002126 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 741091002127 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 741091002128 Active Sites [active] 741091002129 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 741091002130 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 741091002131 CysD dimerization site [polypeptide binding]; other site 741091002132 G1 box; other site 741091002133 putative GEF interaction site [polypeptide binding]; other site 741091002134 GTP/Mg2+ binding site [chemical binding]; other site 741091002135 Switch I region; other site 741091002136 G2 box; other site 741091002137 G3 box; other site 741091002138 Switch II region; other site 741091002139 G4 box; other site 741091002140 G5 box; other site 741091002141 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 741091002142 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 741091002143 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 741091002144 ligand-binding site [chemical binding]; other site 741091002145 hypothetical protein; Provisional; Region: PRK10726 741091002146 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 741091002147 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 741091002148 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 741091002149 substrate binding site; other site 741091002150 dimer interface; other site 741091002151 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 741091002152 homotrimer interaction site [polypeptide binding]; other site 741091002153 zinc binding site [ion binding]; other site 741091002154 CDP-binding sites; other site 741091002155 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 741091002156 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 741091002157 Permutation of conserved domain; other site 741091002158 active site 741091002159 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 741091002160 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 741091002161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091002162 S-adenosylmethionine binding site [chemical binding]; other site 741091002163 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 741091002164 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741091002165 Peptidase family M23; Region: Peptidase_M23; pfam01551 741091002166 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 741091002167 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 741091002168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 741091002169 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 741091002170 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741091002171 DNA binding residues [nucleotide binding] 741091002172 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 741091002173 MutS domain I; Region: MutS_I; pfam01624 741091002174 MutS domain II; Region: MutS_II; pfam05188 741091002175 MutS domain III; Region: MutS_III; pfam05192 741091002176 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 741091002177 Walker A/P-loop; other site 741091002178 ATP binding site [chemical binding]; other site 741091002179 Q-loop/lid; other site 741091002180 ABC transporter signature motif; other site 741091002181 Walker B; other site 741091002182 D-loop; other site 741091002183 H-loop/switch region; other site 741091002184 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 741091002185 putative lipoprotein; Provisional; Region: PRK10533 741091002186 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741091002187 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741091002188 catalytic residue [active] 741091002189 hypothetical protein; Validated; Region: PRK03661 741091002190 recombinase A; Provisional; Region: recA; PRK09354 741091002191 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 741091002192 hexamer interface [polypeptide binding]; other site 741091002193 Walker A motif; other site 741091002194 ATP binding site [chemical binding]; other site 741091002195 Walker B motif; other site 741091002196 recombination regulator RecX; Reviewed; Region: recX; PRK00117 741091002197 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 741091002198 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 741091002199 motif 1; other site 741091002200 active site 741091002201 motif 2; other site 741091002202 motif 3; other site 741091002203 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 741091002204 DHHA1 domain; Region: DHHA1; pfam02272 741091002205 carbon storage regulator; Provisional; Region: PRK01712 741091002206 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 741091002207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091002208 motif II; other site 741091002209 Predicted membrane protein [Function unknown]; Region: COG1238 741091002210 glutamate--cysteine ligase; Provisional; Region: PRK02107 741091002211 S-ribosylhomocysteinase; Provisional; Region: PRK02260 741091002212 hypothetical protein; Provisional; Region: PRK11573 741091002213 Domain of unknown function DUF21; Region: DUF21; pfam01595 741091002214 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 741091002215 Transporter associated domain; Region: CorC_HlyC; smart01091 741091002216 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 741091002217 signal recognition particle protein; Provisional; Region: PRK10867 741091002218 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 741091002219 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 741091002220 P loop; other site 741091002221 GTP binding site [chemical binding]; other site 741091002222 Signal peptide binding domain; Region: SRP_SPB; pfam02978 741091002223 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 741091002224 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 741091002225 RimM N-terminal domain; Region: RimM; pfam01782 741091002226 PRC-barrel domain; Region: PRC; pfam05239 741091002227 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 741091002228 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 741091002229 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 741091002230 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 741091002231 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 741091002232 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 741091002233 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 741091002234 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 741091002235 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 741091002236 major tail tube protein; Provisional; Region: FII; PHA02600 741091002237 major tail sheath protein; Provisional; Region: FI; PHA02560 741091002238 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 741091002239 Phage Tail Collar Domain; Region: Collar; pfam07484 741091002240 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 741091002241 baseplate assembly protein; Provisional; Region: J; PHA02568 741091002242 baseplate wedge subunit; Provisional; Region: W; PHA02516 741091002243 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 741091002244 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 741091002245 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 741091002246 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 741091002247 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741091002248 catalytic residues [active] 741091002249 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 741091002250 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 741091002251 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 741091002252 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 741091002253 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 741091002254 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 741091002255 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 741091002256 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 741091002257 Chorismate mutase type II; Region: CM_2; cl00693 741091002258 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 741091002259 prephenate dehydrogenase; Validated; Region: PRK08507 741091002260 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 741091002261 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 741091002262 Prephenate dehydratase; Region: PDT; pfam00800 741091002263 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 741091002264 putative L-Phe binding site [chemical binding]; other site 741091002265 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 741091002266 30S subunit binding site; other site 741091002267 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 741091002268 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 741091002269 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741091002270 RNA binding surface [nucleotide binding]; other site 741091002271 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 741091002272 active site 741091002273 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 741091002274 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 741091002275 protein disaggregation chaperone; Provisional; Region: PRK10865 741091002276 Clp amino terminal domain; Region: Clp_N; pfam02861 741091002277 Clp amino terminal domain; Region: Clp_N; pfam02861 741091002278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091002279 Walker A motif; other site 741091002280 ATP binding site [chemical binding]; other site 741091002281 Walker B motif; other site 741091002282 arginine finger; other site 741091002283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091002284 Walker A motif; other site 741091002285 ATP binding site [chemical binding]; other site 741091002286 Walker B motif; other site 741091002287 arginine finger; other site 741091002288 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 741091002289 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 741091002290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091002291 putative substrate translocation pore; other site 741091002292 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 741091002293 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 741091002294 domain interface [polypeptide binding]; other site 741091002295 putative active site [active] 741091002296 catalytic site [active] 741091002297 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 741091002298 domain interface [polypeptide binding]; other site 741091002299 putative active site [active] 741091002300 catalytic site [active] 741091002301 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 741091002302 CoA binding domain; Region: CoA_binding_2; pfam13380 741091002303 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 741091002304 Recombinase Flp protein; Region: Flp_C; pfam05202 741091002305 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 741091002306 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 741091002307 Uncharacterized conserved protein [Function unknown]; Region: COG3148 741091002308 thioredoxin 2; Provisional; Region: PRK10996 741091002309 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 741091002310 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 741091002311 catalytic residues [active] 741091002312 putative methyltransferase; Provisional; Region: PRK10864 741091002313 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 741091002314 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 741091002315 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 741091002316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091002317 putative substrate translocation pore; other site 741091002318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091002319 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 741091002320 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091002321 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091002322 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 741091002323 transcriptional repressor MprA; Provisional; Region: PRK10870 741091002324 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 741091002325 putative L-valine exporter; Provisional; Region: PRK10408 741091002326 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 741091002327 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 741091002328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091002329 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 741091002330 YcfA-like protein; Region: YcfA; pfam07927 741091002331 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 741091002332 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 741091002333 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 741091002334 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 741091002335 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 741091002336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091002337 dimer interface [polypeptide binding]; other site 741091002338 conserved gate region; other site 741091002339 putative PBP binding loops; other site 741091002340 ABC-ATPase subunit interface; other site 741091002341 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 741091002342 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 741091002343 Walker A/P-loop; other site 741091002344 ATP binding site [chemical binding]; other site 741091002345 Q-loop/lid; other site 741091002346 ABC transporter signature motif; other site 741091002347 Walker B; other site 741091002348 D-loop; other site 741091002349 H-loop/switch region; other site 741091002350 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 741091002351 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 741091002352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091002353 active site 741091002354 phosphorylation site [posttranslational modification] 741091002355 intermolecular recognition site; other site 741091002356 dimerization interface [polypeptide binding]; other site 741091002357 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 741091002358 PAS domain; Region: PAS; smart00091 741091002359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091002360 ATP binding site [chemical binding]; other site 741091002361 Mg2+ binding site [ion binding]; other site 741091002362 G-X-G motif; other site 741091002363 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 741091002364 NlpC/P60 family; Region: NLPC_P60; pfam00877 741091002365 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091002366 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091002367 active site 741091002368 catalytic tetrad [active] 741091002369 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 741091002370 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 741091002371 dimer interface [polypeptide binding]; other site 741091002372 putative radical transfer pathway; other site 741091002373 diiron center [ion binding]; other site 741091002374 tyrosyl radical; other site 741091002375 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 741091002376 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 741091002377 Class I ribonucleotide reductase; Region: RNR_I; cd01679 741091002378 active site 741091002379 dimer interface [polypeptide binding]; other site 741091002380 catalytic residues [active] 741091002381 effector binding site; other site 741091002382 R2 peptide binding site; other site 741091002383 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 741091002384 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 741091002385 catalytic residues [active] 741091002386 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 741091002387 Uncharacterized conserved protein [Function unknown]; Region: COG2128 741091002388 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 741091002389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091002390 DNA-binding site [nucleotide binding]; DNA binding site 741091002391 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091002392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091002393 homodimer interface [polypeptide binding]; other site 741091002394 catalytic residue [active] 741091002395 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 741091002396 major facilitator superfamily transporter; Provisional; Region: PRK05122 741091002397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091002398 putative substrate translocation pore; other site 741091002399 hypothetical protein; Provisional; Region: PRK10556 741091002400 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091002401 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091002402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091002403 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 741091002404 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 741091002405 6-phosphofructokinase 2; Provisional; Region: PRK10294 741091002406 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 741091002407 putative substrate binding site [chemical binding]; other site 741091002408 putative ATP binding site [chemical binding]; other site 741091002409 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 741091002410 putative active site [active] 741091002411 putative metal binding residues [ion binding]; other site 741091002412 signature motif; other site 741091002413 putative triphosphate binding site [ion binding]; other site 741091002414 dimer interface [polypeptide binding]; other site 741091002415 putative global regulator; Reviewed; Region: PRK09559 741091002416 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 741091002417 hypothetical protein; Provisional; Region: PRK10878 741091002418 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 741091002419 flavodoxin FldB; Provisional; Region: PRK12359 741091002420 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 741091002421 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 741091002422 active site 741091002423 Int/Topo IB signature motif; other site 741091002424 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 741091002425 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 741091002426 dimerization domain [polypeptide binding]; other site 741091002427 dimer interface [polypeptide binding]; other site 741091002428 catalytic residues [active] 741091002429 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 741091002430 DHH family; Region: DHH; pfam01368 741091002431 DHHA1 domain; Region: DHHA1; pfam02272 741091002432 peptide chain release factor 2; Validated; Region: prfB; PRK00578 741091002433 This domain is found in peptide chain release factors; Region: PCRF; smart00937 741091002434 RF-1 domain; Region: RF-1; pfam00472 741091002435 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 741091002436 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 741091002437 dimer interface [polypeptide binding]; other site 741091002438 putative anticodon binding site; other site 741091002439 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 741091002440 motif 1; other site 741091002441 active site 741091002442 motif 2; other site 741091002443 motif 3; other site 741091002444 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 741091002445 argininosuccinate synthase; Validated; Region: PRK05370 741091002446 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091002447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091002448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091002449 dimerization interface [polypeptide binding]; other site 741091002450 glutamate carboxypeptidase; Reviewed; Region: PRK06133 741091002451 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 741091002452 metal binding site [ion binding]; metal-binding site 741091002453 dimer interface [polypeptide binding]; other site 741091002454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 741091002455 Nucleoside recognition; Region: Gate; pfam07670 741091002456 hypothetical protein; Provisional; Region: PRK10519 741091002457 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 741091002458 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 741091002459 metal binding site [ion binding]; metal-binding site 741091002460 putative dimer interface [polypeptide binding]; other site 741091002461 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 741091002462 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091002463 putative DNA binding site [nucleotide binding]; other site 741091002464 putative Zn2+ binding site [ion binding]; other site 741091002465 AsnC family; Region: AsnC_trans_reg; pfam01037 741091002466 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 741091002467 putative arabinose transporter; Provisional; Region: PRK03545 741091002468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091002469 putative substrate translocation pore; other site 741091002470 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 741091002471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 741091002472 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 741091002473 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 741091002474 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 741091002475 catalytic triad [active] 741091002476 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 741091002477 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091002478 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 741091002479 Protein export membrane protein; Region: SecD_SecF; cl14618 741091002480 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 741091002481 Protein export membrane protein; Region: SecD_SecF; cl14618 741091002482 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 741091002483 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 741091002484 putative active site [active] 741091002485 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 741091002486 RelB antitoxin; Region: RelB; cl01171 741091002487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 741091002488 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 741091002489 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 741091002490 Protein export membrane protein; Region: SecD_SecF; cl14618 741091002491 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 741091002492 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091002493 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091002494 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 741091002495 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741091002496 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 741091002497 active site turn [active] 741091002498 phosphorylation site [posttranslational modification] 741091002499 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 741091002500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091002501 DNA-binding site [nucleotide binding]; DNA binding site 741091002502 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 741091002503 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 741091002504 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 741091002505 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 741091002506 Tetratricopeptide repeat; Region: TPR_12; pfam13424 741091002507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 741091002508 TPR motif; other site 741091002509 binding surface 741091002510 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 741091002511 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091002512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091002513 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 741091002514 putative effector binding pocket; other site 741091002515 dimerization interface [polypeptide binding]; other site 741091002516 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 741091002517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091002518 putative substrate translocation pore; other site 741091002519 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 741091002520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091002521 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091002522 dimerization interface [polypeptide binding]; other site 741091002523 diaminopimelate decarboxylase; Provisional; Region: PRK11165 741091002524 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 741091002525 active site 741091002526 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 741091002527 substrate binding site [chemical binding]; other site 741091002528 catalytic residues [active] 741091002529 dimer interface [polypeptide binding]; other site 741091002530 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 741091002531 methionine cluster; other site 741091002532 active site 741091002533 phosphorylation site [posttranslational modification] 741091002534 metal binding site [ion binding]; metal-binding site 741091002535 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 741091002536 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 741091002537 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 741091002538 beta-galactosidase; Region: BGL; TIGR03356 741091002539 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 741091002540 active site 741091002541 P-loop; other site 741091002542 phosphorylation site [posttranslational modification] 741091002543 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 741091002544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091002545 DNA-binding site [nucleotide binding]; DNA binding site 741091002546 FCD domain; Region: FCD; pfam07729 741091002547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091002548 Coenzyme A binding pocket [chemical binding]; other site 741091002549 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 741091002550 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091002551 DNA binding site [nucleotide binding] 741091002552 domain linker motif; other site 741091002553 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 741091002554 dimerization interface (closed form) [polypeptide binding]; other site 741091002555 ligand binding site [chemical binding]; other site 741091002556 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 741091002557 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 741091002558 molybdopterin cofactor binding site [chemical binding]; other site 741091002559 substrate binding site [chemical binding]; other site 741091002560 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 741091002561 molybdopterin cofactor binding site; other site 741091002562 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 741091002563 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 741091002564 putative acyl-acceptor binding pocket; other site 741091002565 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 741091002566 acyl-activating enzyme (AAE) consensus motif; other site 741091002567 putative AMP binding site [chemical binding]; other site 741091002568 lysophospholipid transporter LplT; Provisional; Region: PRK11195 741091002569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091002570 putative substrate translocation pore; other site 741091002571 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091002572 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091002573 active site 741091002574 catalytic tetrad [active] 741091002575 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 741091002576 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 741091002577 putative DNA-binding cleft [nucleotide binding]; other site 741091002578 putative DNA clevage site; other site 741091002579 molecular lever; other site 741091002580 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 741091002581 putative active site [active] 741091002582 Ap4A binding site [chemical binding]; other site 741091002583 nudix motif; other site 741091002584 putative metal binding site [ion binding]; other site 741091002585 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 741091002586 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 741091002587 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 741091002588 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 741091002589 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 741091002590 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 741091002591 thymidylate synthase; Reviewed; Region: thyA; PRK01827 741091002592 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 741091002593 dimerization interface [polypeptide binding]; other site 741091002594 active site 741091002595 hypothetical protein; Provisional; Region: PRK10506 741091002596 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 741091002597 hypothetical protein; Provisional; Region: PRK10557 741091002598 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 741091002599 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 741091002600 protease3; Provisional; Region: PRK15101 741091002601 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 741091002602 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 741091002603 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 741091002604 N-acetylglutamate synthase; Validated; Region: PRK05279 741091002605 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 741091002606 putative feedback inhibition sensing region; other site 741091002607 putative nucleotide binding site [chemical binding]; other site 741091002608 putative substrate binding site [chemical binding]; other site 741091002609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091002610 Coenzyme A binding pocket [chemical binding]; other site 741091002611 AMIN domain; Region: AMIN; pfam11741 741091002612 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 741091002613 active site 741091002614 metal binding site [ion binding]; metal-binding site 741091002615 murein transglycosylase A; Provisional; Region: mltA; PRK11162 741091002616 MltA specific insert domain; Region: MltA; smart00925 741091002617 3D domain; Region: 3D; pfam06725 741091002618 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 741091002619 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 741091002620 putative ATP binding site [chemical binding]; other site 741091002621 putative substrate interface [chemical binding]; other site 741091002622 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 741091002623 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 741091002624 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 741091002625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741091002626 catalytic residue [active] 741091002627 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 741091002628 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 741091002629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091002630 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 741091002631 dimerization interface [polypeptide binding]; other site 741091002632 substrate binding pocket [chemical binding]; other site 741091002633 hypothetical protein; Provisional; Region: PRK10873 741091002634 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 741091002635 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 741091002636 flap endonuclease-like protein; Provisional; Region: PRK09482 741091002637 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 741091002638 active site 741091002639 metal binding site 1 [ion binding]; metal-binding site 741091002640 putative 5' ssDNA interaction site; other site 741091002641 metal binding site 3; metal-binding site 741091002642 metal binding site 2 [ion binding]; metal-binding site 741091002643 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 741091002644 putative DNA binding site [nucleotide binding]; other site 741091002645 putative metal binding site [ion binding]; other site 741091002646 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 741091002647 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 741091002648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 741091002649 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 741091002650 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 741091002651 SecY interacting protein Syd; Provisional; Region: PRK04968 741091002652 benzoate transport; Region: 2A0115; TIGR00895 741091002653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091002654 putative substrate translocation pore; other site 741091002655 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 741091002656 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 741091002657 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 741091002658 probable active site [active] 741091002659 flavodoxin; Provisional; Region: PRK08105 741091002660 hypothetical protein; Provisional; Region: PRK13677 741091002661 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 741091002662 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 741091002663 trimer interface [polypeptide binding]; other site 741091002664 active site 741091002665 substrate binding site [chemical binding]; other site 741091002666 CoA binding site [chemical binding]; other site 741091002667 PII uridylyl-transferase; Provisional; Region: PRK05007 741091002668 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 741091002669 metal binding triad; other site 741091002670 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 741091002671 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 741091002672 Zn2+ binding site [ion binding]; other site 741091002673 Mg2+ binding site [ion binding]; other site 741091002674 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 741091002675 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 741091002676 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 741091002677 active site 741091002678 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 741091002679 rRNA interaction site [nucleotide binding]; other site 741091002680 S8 interaction site; other site 741091002681 putative laminin-1 binding site; other site 741091002682 elongation factor Ts; Provisional; Region: tsf; PRK09377 741091002683 UBA/TS-N domain; Region: UBA; pfam00627 741091002684 Elongation factor TS; Region: EF_TS; pfam00889 741091002685 Elongation factor TS; Region: EF_TS; pfam00889 741091002686 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 741091002687 putative nucleotide binding site [chemical binding]; other site 741091002688 uridine monophosphate binding site [chemical binding]; other site 741091002689 homohexameric interface [polypeptide binding]; other site 741091002690 ribosome recycling factor; Reviewed; Region: frr; PRK00083 741091002691 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 741091002692 hinge region; other site 741091002693 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 741091002694 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 741091002695 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 741091002696 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 741091002697 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 741091002698 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 741091002699 catalytic residue [active] 741091002700 putative FPP diphosphate binding site; other site 741091002701 putative FPP binding hydrophobic cleft; other site 741091002702 dimer interface [polypeptide binding]; other site 741091002703 putative IPP diphosphate binding site; other site 741091002704 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 741091002705 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 741091002706 zinc metallopeptidase RseP; Provisional; Region: PRK10779 741091002707 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 741091002708 active site 741091002709 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 741091002710 protein binding site [polypeptide binding]; other site 741091002711 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 741091002712 protein binding site [polypeptide binding]; other site 741091002713 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 741091002714 putative substrate binding region [chemical binding]; other site 741091002715 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 741091002716 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741091002717 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741091002718 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741091002719 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741091002720 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741091002721 Surface antigen; Region: Bac_surface_Ag; pfam01103 741091002722 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 741091002723 periplasmic chaperone; Provisional; Region: PRK10780 741091002724 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 741091002725 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 741091002726 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 741091002727 trimer interface [polypeptide binding]; other site 741091002728 active site 741091002729 UDP-GlcNAc binding site [chemical binding]; other site 741091002730 lipid binding site [chemical binding]; lipid-binding site 741091002731 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 741091002732 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 741091002733 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 741091002734 active site 741091002735 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 741091002736 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 741091002737 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 741091002738 RNA/DNA hybrid binding site [nucleotide binding]; other site 741091002739 active site 741091002740 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 741091002741 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 741091002742 putative active site [active] 741091002743 putative PHP Thumb interface [polypeptide binding]; other site 741091002744 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 741091002745 generic binding surface II; other site 741091002746 generic binding surface I; other site 741091002747 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 741091002748 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 741091002749 lysine decarboxylase LdcC; Provisional; Region: PRK15399 741091002750 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 741091002751 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 741091002752 homodimer interface [polypeptide binding]; other site 741091002753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091002754 catalytic residue [active] 741091002755 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 741091002756 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 741091002757 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 741091002758 putative metal binding site [ion binding]; other site 741091002759 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 741091002760 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 741091002761 Ligand Binding Site [chemical binding]; other site 741091002762 TilS substrate binding domain; Region: TilS; pfam09179 741091002763 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 741091002764 Cytochrome c553 [Energy production and conversion]; Region: COG2863 741091002765 Rho-binding antiterminator; Provisional; Region: PRK11625 741091002766 hypothetical protein; Provisional; Region: PRK04964 741091002767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 741091002768 hypothetical protein; Provisional; Region: PRK09256 741091002769 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 741091002770 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 741091002771 NlpE N-terminal domain; Region: NlpE; pfam04170 741091002772 prolyl-tRNA synthetase; Provisional; Region: PRK09194 741091002773 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 741091002774 dimer interface [polypeptide binding]; other site 741091002775 motif 1; other site 741091002776 active site 741091002777 motif 2; other site 741091002778 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 741091002779 putative deacylase active site [active] 741091002780 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 741091002781 active site 741091002782 motif 3; other site 741091002783 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 741091002784 anticodon binding site; other site 741091002785 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 741091002786 homodimer interaction site [polypeptide binding]; other site 741091002787 cofactor binding site; other site 741091002788 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 741091002789 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 741091002790 lipoprotein, YaeC family; Region: TIGR00363 741091002791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091002792 dimer interface [polypeptide binding]; other site 741091002793 conserved gate region; other site 741091002794 ABC-ATPase subunit interface; other site 741091002795 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 741091002796 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 741091002797 Walker A/P-loop; other site 741091002798 ATP binding site [chemical binding]; other site 741091002799 Q-loop/lid; other site 741091002800 ABC transporter signature motif; other site 741091002801 Walker B; other site 741091002802 D-loop; other site 741091002803 H-loop/switch region; other site 741091002804 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 741091002805 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 741091002806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091002807 active site 741091002808 motif I; other site 741091002809 motif II; other site 741091002810 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 741091002811 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 741091002812 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 741091002813 putative acyl-acceptor binding pocket; other site 741091002814 Phosphopantetheine attachment site; Region: PP-binding; cl09936 741091002815 acyl carrier protein; Provisional; Region: PRK05350 741091002816 Predicted membrane protein [Function unknown]; Region: COG4648 741091002817 AMP-binding enzyme; Region: AMP-binding; pfam00501 741091002818 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 741091002819 acyl-activating enzyme (AAE) consensus motif; other site 741091002820 AMP binding site [chemical binding]; other site 741091002821 active site 741091002822 CoA binding site [chemical binding]; other site 741091002823 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 741091002824 active site 2 [active] 741091002825 dimer interface [polypeptide binding]; other site 741091002826 active site 1 [active] 741091002827 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 741091002828 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 741091002829 Ligand binding site; other site 741091002830 Putative Catalytic site; other site 741091002831 DXD motif; other site 741091002832 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 741091002833 putative acyl-acceptor binding pocket; other site 741091002834 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 741091002835 active site 741091002836 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 741091002837 Predicted exporter [General function prediction only]; Region: COG4258 741091002838 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 741091002839 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 741091002840 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 741091002841 dimer interface [polypeptide binding]; other site 741091002842 active site 741091002843 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 741091002844 putative active site 1 [active] 741091002845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091002846 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 741091002847 NAD(P) binding site [chemical binding]; other site 741091002848 active site 741091002849 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 741091002850 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 741091002851 dimer interface [polypeptide binding]; other site 741091002852 active site 741091002853 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 741091002854 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 741091002855 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091002856 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091002857 active site 741091002858 catalytic tetrad [active] 741091002859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091002860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091002861 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091002862 dimerization interface [polypeptide binding]; other site 741091002863 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 741091002864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091002865 putative substrate translocation pore; other site 741091002866 hypothetical protein; Provisional; Region: PRK05421 741091002867 putative catalytic site [active] 741091002868 putative metal binding site [ion binding]; other site 741091002869 putative catalytic site [active] 741091002870 putative phosphate binding site [ion binding]; other site 741091002871 putative phosphate binding site [ion binding]; other site 741091002872 putative metal binding site [ion binding]; other site 741091002873 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 741091002874 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741091002875 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741091002876 catalytic residue [active] 741091002877 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741091002878 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741091002879 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 741091002880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091002881 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 741091002882 RNA/DNA hybrid binding site [nucleotide binding]; other site 741091002883 active site 741091002884 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 741091002885 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 741091002886 putative active site; other site 741091002887 catalytic triad [active] 741091002888 putative dimer interface [polypeptide binding]; other site 741091002889 agmatine deiminase; Provisional; Region: PRK13551 741091002890 agmatine deiminase; Region: agmatine_aguA; TIGR03380 741091002891 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 741091002892 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 741091002893 active site 741091002894 catalytic site [active] 741091002895 substrate binding site [chemical binding]; other site 741091002896 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 741091002897 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 741091002898 Na binding site [ion binding]; other site 741091002899 putative substrate binding site [chemical binding]; other site 741091002900 Transcriptional regulators [Transcription]; Region: FadR; COG2186 741091002901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091002902 DNA-binding site [nucleotide binding]; DNA binding site 741091002903 FCD domain; Region: FCD; pfam07729 741091002904 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 741091002905 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 741091002906 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 741091002907 active site 741091002908 catalytic site [active] 741091002909 tetramer interface [polypeptide binding]; other site 741091002910 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 741091002911 SnoaL-like domain; Region: SnoaL_3; pfam13474 741091002912 amidase; Provisional; Region: PRK09201 741091002913 Amidase; Region: Amidase; cl11426 741091002914 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 741091002915 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 741091002916 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 741091002917 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 741091002918 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741091002919 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 741091002920 putative active site [active] 741091002921 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 741091002922 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091002923 substrate binding pocket [chemical binding]; other site 741091002924 membrane-bound complex binding site; other site 741091002925 hinge residues; other site 741091002926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091002927 dimer interface [polypeptide binding]; other site 741091002928 conserved gate region; other site 741091002929 putative PBP binding loops; other site 741091002930 ABC-ATPase subunit interface; other site 741091002931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091002932 ABC-ATPase subunit interface; other site 741091002933 putative PBP binding loops; other site 741091002934 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741091002935 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091002936 Walker A/P-loop; other site 741091002937 ATP binding site [chemical binding]; other site 741091002938 Q-loop/lid; other site 741091002939 ABC transporter signature motif; other site 741091002940 Walker B; other site 741091002941 D-loop; other site 741091002942 H-loop/switch region; other site 741091002943 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 741091002944 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741091002945 catalytic residue [active] 741091002946 allantoate amidohydrolase; Reviewed; Region: PRK09290 741091002947 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 741091002948 active site 741091002949 metal binding site [ion binding]; metal-binding site 741091002950 dimer interface [polypeptide binding]; other site 741091002951 OHCU decarboxylase; Region: UraD_2; TIGR03180 741091002952 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 741091002953 active site 741091002954 homotetramer interface [polypeptide binding]; other site 741091002955 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 741091002956 conserved cys residue [active] 741091002957 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 741091002958 C-N hydrolase family amidase; Provisional; Region: PRK10438 741091002959 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 741091002960 putative active site [active] 741091002961 catalytic triad [active] 741091002962 dimer interface [polypeptide binding]; other site 741091002963 multimer interface [polypeptide binding]; other site 741091002964 methionine aminotransferase; Validated; Region: PRK09082 741091002965 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091002966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091002967 homodimer interface [polypeptide binding]; other site 741091002968 catalytic residue [active] 741091002969 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 741091002970 intersubunit interface [polypeptide binding]; other site 741091002971 active site 741091002972 Zn2+ binding site [ion binding]; other site 741091002973 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 741091002974 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 741091002975 Cupin domain; Region: Cupin_2; cl17218 741091002976 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 741091002977 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 741091002978 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 741091002979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 741091002980 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 741091002981 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 741091002982 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 741091002983 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 741091002984 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 741091002985 active site 741091002986 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 741091002987 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 741091002988 dimer interface [polypeptide binding]; other site 741091002989 active site 741091002990 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 741091002991 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 741091002992 putative active site [active] 741091002993 putative dimer interface [polypeptide binding]; other site 741091002994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 741091002995 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 741091002996 active site 741091002997 DNA polymerase IV; Validated; Region: PRK02406 741091002998 DNA binding site [nucleotide binding] 741091002999 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 741091003000 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 741091003001 metal binding site [ion binding]; metal-binding site 741091003002 dimer interface [polypeptide binding]; other site 741091003003 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741091003004 active site 741091003005 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 741091003006 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 741091003007 gamma-glutamyl kinase; Provisional; Region: PRK05429 741091003008 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 741091003009 nucleotide binding site [chemical binding]; other site 741091003010 homotetrameric interface [polypeptide binding]; other site 741091003011 putative phosphate binding site [ion binding]; other site 741091003012 putative allosteric binding site; other site 741091003013 PUA domain; Region: PUA; pfam01472 741091003014 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 741091003015 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 741091003016 putative catalytic cysteine [active] 741091003017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091003018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091003019 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091003020 dimerization interface [polypeptide binding]; other site 741091003021 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 741091003022 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 741091003023 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741091003024 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741091003025 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 741091003026 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 741091003027 PAAR motif; Region: PAAR_motif; pfam05488 741091003028 S-type Pyocin; Region: Pyocin_S; pfam06958 741091003029 Cytotoxic; Region: Cytotoxic; pfam09000 741091003030 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 741091003031 NIPSNAP; Region: NIPSNAP; pfam07978 741091003032 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091003033 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091003034 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 741091003035 putative effector binding pocket; other site 741091003036 putative dimerization interface [polypeptide binding]; other site 741091003037 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091003038 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091003039 active site 741091003040 catalytic tetrad [active] 741091003041 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091003042 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091003043 active site 741091003044 catalytic tetrad [active] 741091003045 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741091003046 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 741091003047 Domain of unknown function (DUF333); Region: DUF333; pfam03891 741091003048 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 741091003049 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 741091003050 metal binding site [ion binding]; metal-binding site 741091003051 putative dimer interface [polypeptide binding]; other site 741091003052 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 741091003053 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 741091003054 trimer interface [polypeptide binding]; other site 741091003055 active site 741091003056 substrate binding site [chemical binding]; other site 741091003057 CoA binding site [chemical binding]; other site 741091003058 Cache domain; Region: Cache_1; pfam02743 741091003059 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091003060 dimerization interface [polypeptide binding]; other site 741091003061 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 741091003062 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091003063 dimer interface [polypeptide binding]; other site 741091003064 putative CheW interface [polypeptide binding]; other site 741091003065 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 741091003066 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 741091003067 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 741091003068 ligand binding site [chemical binding]; other site 741091003069 dimerization interface [polypeptide binding]; other site 741091003070 zinc binding site [ion binding]; other site 741091003071 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 741091003072 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741091003073 Walker A/P-loop; other site 741091003074 ATP binding site [chemical binding]; other site 741091003075 Q-loop/lid; other site 741091003076 ABC transporter signature motif; other site 741091003077 Walker B; other site 741091003078 D-loop; other site 741091003079 H-loop/switch region; other site 741091003080 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741091003081 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091003082 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091003083 TM-ABC transporter signature motif; other site 741091003084 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 741091003085 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741091003086 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 741091003087 putative active site [active] 741091003088 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741091003089 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 741091003090 substrate binding site [chemical binding]; other site 741091003091 dimer interface [polypeptide binding]; other site 741091003092 ATP binding site [chemical binding]; other site 741091003093 Rdx family; Region: Rdx; cl01407 741091003094 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 741091003095 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 741091003096 active site 741091003097 FMN binding site [chemical binding]; other site 741091003098 substrate binding site [chemical binding]; other site 741091003099 homotetramer interface [polypeptide binding]; other site 741091003100 catalytic residue [active] 741091003101 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 741091003102 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 741091003103 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 741091003104 Part of AAA domain; Region: AAA_19; pfam13245 741091003105 Family description; Region: UvrD_C_2; pfam13538 741091003106 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 741091003107 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 741091003108 AAA domain; Region: AAA_30; pfam13604 741091003109 Family description; Region: UvrD_C_2; pfam13538 741091003110 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 741091003111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091003112 putative substrate translocation pore; other site 741091003113 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 741091003114 Beta-lactamase; Region: Beta-lactamase; pfam00144 741091003115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091003116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091003117 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 741091003118 putative effector binding pocket; other site 741091003119 putative dimerization interface [polypeptide binding]; other site 741091003120 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 741091003121 Coenzyme A binding pocket [chemical binding]; other site 741091003122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091003123 non-specific DNA binding site [nucleotide binding]; other site 741091003124 salt bridge; other site 741091003125 sequence-specific DNA binding site [nucleotide binding]; other site 741091003126 2TM domain; Region: 2TM; pfam13239 741091003127 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 741091003128 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091003129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091003130 metal binding site [ion binding]; metal-binding site 741091003131 active site 741091003132 I-site; other site 741091003133 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 741091003134 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 741091003135 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741091003136 DNA-binding site [nucleotide binding]; DNA binding site 741091003137 RNA-binding motif; other site 741091003138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091003139 D-galactonate transporter; Region: 2A0114; TIGR00893 741091003140 putative substrate translocation pore; other site 741091003141 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 741091003142 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 741091003143 active site 741091003144 tetramer interface [polypeptide binding]; other site 741091003145 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 741091003146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091003147 putative substrate translocation pore; other site 741091003148 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 741091003149 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 741091003150 catalytic site [active] 741091003151 penicillin-binding protein 2; Provisional; Region: PRK10795 741091003152 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 741091003153 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 741091003154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 741091003155 HAMP domain; Region: HAMP; pfam00672 741091003156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091003157 dimer interface [polypeptide binding]; other site 741091003158 phosphorylation site [posttranslational modification] 741091003159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091003160 ATP binding site [chemical binding]; other site 741091003161 Mg2+ binding site [ion binding]; other site 741091003162 G-X-G motif; other site 741091003163 hypothetical protein; Provisional; Region: PRK10722 741091003164 response regulator GlrR; Provisional; Region: PRK15115 741091003165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091003166 active site 741091003167 phosphorylation site [posttranslational modification] 741091003168 intermolecular recognition site; other site 741091003169 dimerization interface [polypeptide binding]; other site 741091003170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091003171 Walker A motif; other site 741091003172 ATP binding site [chemical binding]; other site 741091003173 Walker B motif; other site 741091003174 arginine finger; other site 741091003175 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 741091003176 Nitrogen regulatory protein P-II; Region: P-II; smart00938 741091003177 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 741091003178 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 741091003179 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 741091003180 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 741091003181 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 741091003182 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 741091003183 Cytochrome c; Region: Cytochrom_C; pfam00034 741091003184 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 741091003185 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 741091003186 heme-binding site [chemical binding]; other site 741091003187 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 741091003188 FAD binding pocket [chemical binding]; other site 741091003189 FAD binding motif [chemical binding]; other site 741091003190 phosphate binding motif [ion binding]; other site 741091003191 beta-alpha-beta structure motif; other site 741091003192 NAD binding pocket [chemical binding]; other site 741091003193 Heme binding pocket [chemical binding]; other site 741091003194 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 741091003195 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 741091003196 dimer interface [polypeptide binding]; other site 741091003197 active site 741091003198 glycine-pyridoxal phosphate binding site [chemical binding]; other site 741091003199 folate binding site [chemical binding]; other site 741091003200 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 741091003201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091003202 putative substrate translocation pore; other site 741091003203 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 741091003204 PRD domain; Region: PRD; pfam00874 741091003205 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 741091003206 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 741091003207 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 741091003208 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 741091003209 active site 741091003210 dimerization interface [polypeptide binding]; other site 741091003211 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 741091003212 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 741091003213 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 741091003214 Rrf2 family protein; Region: rrf2_super; TIGR00738 741091003215 cysteine desulfurase; Provisional; Region: PRK14012 741091003216 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 741091003217 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741091003218 catalytic residue [active] 741091003219 aminopeptidase B; Provisional; Region: PRK05015 741091003220 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 741091003221 interface (dimer of trimers) [polypeptide binding]; other site 741091003222 Substrate-binding/catalytic site; other site 741091003223 Zn-binding sites [ion binding]; other site 741091003224 SseB protein; Region: SseB; pfam07179 741091003225 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 741091003226 active site 741091003227 multimer interface [polypeptide binding]; other site 741091003228 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 741091003229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091003230 FeS/SAM binding site; other site 741091003231 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 741091003232 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 741091003233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741091003234 binding surface 741091003235 TPR motif; other site 741091003236 cytoskeletal protein RodZ; Provisional; Region: PRK10856 741091003237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091003238 non-specific DNA binding site [nucleotide binding]; other site 741091003239 salt bridge; other site 741091003240 sequence-specific DNA binding site [nucleotide binding]; other site 741091003241 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 741091003242 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 741091003243 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 741091003244 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 741091003245 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 741091003246 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 741091003247 dimer interface [polypeptide binding]; other site 741091003248 motif 1; other site 741091003249 active site 741091003250 motif 2; other site 741091003251 motif 3; other site 741091003252 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 741091003253 anticodon binding site; other site 741091003254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 741091003255 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 741091003256 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 741091003257 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 741091003258 Trp docking motif [polypeptide binding]; other site 741091003259 GTP-binding protein Der; Reviewed; Region: PRK00093 741091003260 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 741091003261 G1 box; other site 741091003262 GTP/Mg2+ binding site [chemical binding]; other site 741091003263 Switch I region; other site 741091003264 G2 box; other site 741091003265 Switch II region; other site 741091003266 G3 box; other site 741091003267 G4 box; other site 741091003268 G5 box; other site 741091003269 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 741091003270 G1 box; other site 741091003271 GTP/Mg2+ binding site [chemical binding]; other site 741091003272 Switch I region; other site 741091003273 G2 box; other site 741091003274 G3 box; other site 741091003275 Switch II region; other site 741091003276 G4 box; other site 741091003277 G5 box; other site 741091003278 Predicted permeases [General function prediction only]; Region: COG0679 741091003279 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 741091003280 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 741091003281 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 741091003282 active site 741091003283 Zn binding site [ion binding]; other site 741091003284 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741091003285 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091003286 DNA binding site [nucleotide binding] 741091003287 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 741091003288 ligand binding site [chemical binding]; other site 741091003289 dimerization interface [polypeptide binding]; other site 741091003290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091003291 D-galactonate transporter; Region: 2A0114; TIGR00893 741091003292 putative substrate translocation pore; other site 741091003293 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 741091003294 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 741091003295 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 741091003296 putative active site [active] 741091003297 putative catalytic site [active] 741091003298 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 741091003299 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 741091003300 generic binding surface II; other site 741091003301 generic binding surface I; other site 741091003302 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 741091003303 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 741091003304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 741091003305 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 741091003306 active site 741091003307 GMP synthase; Reviewed; Region: guaA; PRK00074 741091003308 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 741091003309 AMP/PPi binding site [chemical binding]; other site 741091003310 candidate oxyanion hole; other site 741091003311 catalytic triad [active] 741091003312 potential glutamine specificity residues [chemical binding]; other site 741091003313 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 741091003314 ATP Binding subdomain [chemical binding]; other site 741091003315 Ligand Binding sites [chemical binding]; other site 741091003316 Dimerization subdomain; other site 741091003317 PAS domain S-box; Region: sensory_box; TIGR00229 741091003318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091003319 putative active site [active] 741091003320 heme pocket [chemical binding]; other site 741091003321 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 741091003322 GAF domain; Region: GAF; pfam01590 741091003323 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091003324 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091003325 metal binding site [ion binding]; metal-binding site 741091003326 active site 741091003327 I-site; other site 741091003328 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 741091003329 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 741091003330 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091003331 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091003332 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091003333 dimerization interface [polypeptide binding]; other site 741091003334 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 741091003335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 741091003336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091003337 Coenzyme A binding pocket [chemical binding]; other site 741091003338 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 741091003339 substrate binding site [chemical binding]; other site 741091003340 multimerization interface [polypeptide binding]; other site 741091003341 ATP binding site [chemical binding]; other site 741091003342 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 741091003343 dimer interface [polypeptide binding]; other site 741091003344 substrate binding site [chemical binding]; other site 741091003345 ATP binding site [chemical binding]; other site 741091003346 Transcriptional regulators [Transcription]; Region: GntR; COG1802 741091003347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091003348 DNA-binding site [nucleotide binding]; DNA binding site 741091003349 FCD domain; Region: FCD; pfam07729 741091003350 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 741091003351 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 741091003352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091003353 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 741091003354 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 741091003355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 741091003356 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 741091003357 chorismate mutase; Provisional; Region: PRK08055 741091003358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091003359 D-galactonate transporter; Region: 2A0114; TIGR00893 741091003360 putative substrate translocation pore; other site 741091003361 putative oxidoreductase; Provisional; Region: PRK10083 741091003362 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 741091003363 putative NAD(P) binding site [chemical binding]; other site 741091003364 catalytic Zn binding site [ion binding]; other site 741091003365 structural Zn binding site [ion binding]; other site 741091003366 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 741091003367 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 741091003368 putative active site pocket [active] 741091003369 putative metal binding site [ion binding]; other site 741091003370 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 741091003371 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 741091003372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091003373 putative substrate translocation pore; other site 741091003374 lipid kinase; Reviewed; Region: PRK13054 741091003375 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 741091003376 putative protease; Provisional; Region: PRK15452 741091003377 Peptidase family U32; Region: Peptidase_U32; pfam01136 741091003378 Uncharacterized conserved protein [Function unknown]; Region: COG3422 741091003379 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 741091003380 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 741091003381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091003382 active site 741091003383 phosphorylation site [posttranslational modification] 741091003384 intermolecular recognition site; other site 741091003385 dimerization interface [polypeptide binding]; other site 741091003386 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091003387 DNA binding site [nucleotide binding] 741091003388 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 741091003389 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091003390 dimerization interface [polypeptide binding]; other site 741091003391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091003392 dimer interface [polypeptide binding]; other site 741091003393 phosphorylation site [posttranslational modification] 741091003394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091003395 ATP binding site [chemical binding]; other site 741091003396 Mg2+ binding site [ion binding]; other site 741091003397 G-X-G motif; other site 741091003398 putative transporter; Provisional; Region: PRK10504 741091003399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091003400 putative substrate translocation pore; other site 741091003401 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091003402 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091003403 active site 741091003404 catalytic tetrad [active] 741091003405 putative chaperone; Provisional; Region: PRK11678 741091003406 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 741091003407 nucleotide binding site [chemical binding]; other site 741091003408 putative NEF/HSP70 interaction site [polypeptide binding]; other site 741091003409 SBD interface [polypeptide binding]; other site 741091003410 transketolase; Reviewed; Region: PRK12753 741091003411 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 741091003412 TPP-binding site [chemical binding]; other site 741091003413 dimer interface [polypeptide binding]; other site 741091003414 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 741091003415 PYR/PP interface [polypeptide binding]; other site 741091003416 dimer interface [polypeptide binding]; other site 741091003417 TPP binding site [chemical binding]; other site 741091003418 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 741091003419 transaldolase-like protein; Provisional; Region: PTZ00411 741091003420 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 741091003421 active site 741091003422 dimer interface [polypeptide binding]; other site 741091003423 catalytic residue [active] 741091003424 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 741091003425 Malic enzyme, N-terminal domain; Region: malic; pfam00390 741091003426 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 741091003427 putative NAD(P) binding site [chemical binding]; other site 741091003428 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 741091003429 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 741091003430 active site 741091003431 tetramer interface [polypeptide binding]; other site 741091003432 hypothetical protein; Validated; Region: PRK00124 741091003433 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 741091003434 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 741091003435 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 741091003436 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 741091003437 active site 741091003438 metal binding site [ion binding]; metal-binding site 741091003439 putative acetyltransferase; Provisional; Region: PRK03624 741091003440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091003441 Coenzyme A binding pocket [chemical binding]; other site 741091003442 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 741091003443 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 741091003444 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 741091003445 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 741091003446 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 741091003447 thiosulfate transporter subunit; Provisional; Region: PRK10852 741091003448 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 741091003449 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 741091003450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091003451 dimer interface [polypeptide binding]; other site 741091003452 conserved gate region; other site 741091003453 putative PBP binding loops; other site 741091003454 ABC-ATPase subunit interface; other site 741091003455 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 741091003456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091003457 dimer interface [polypeptide binding]; other site 741091003458 conserved gate region; other site 741091003459 putative PBP binding loops; other site 741091003460 ABC-ATPase subunit interface; other site 741091003461 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 741091003462 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 741091003463 Walker A/P-loop; other site 741091003464 ATP binding site [chemical binding]; other site 741091003465 Q-loop/lid; other site 741091003466 ABC transporter signature motif; other site 741091003467 Walker B; other site 741091003468 D-loop; other site 741091003469 H-loop/switch region; other site 741091003470 TOBE-like domain; Region: TOBE_3; pfam12857 741091003471 cysteine synthase B; Region: cysM; TIGR01138 741091003472 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 741091003473 dimer interface [polypeptide binding]; other site 741091003474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091003475 catalytic residue [active] 741091003476 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 741091003477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091003478 active site 741091003479 phosphorylation site [posttranslational modification] 741091003480 intermolecular recognition site; other site 741091003481 dimerization interface [polypeptide binding]; other site 741091003482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091003483 DNA binding site [nucleotide binding] 741091003484 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091003485 dimerization interface [polypeptide binding]; other site 741091003486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091003487 dimer interface [polypeptide binding]; other site 741091003488 phosphorylation site [posttranslational modification] 741091003489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091003490 ATP binding site [chemical binding]; other site 741091003491 Mg2+ binding site [ion binding]; other site 741091003492 G-X-G motif; other site 741091003493 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 741091003494 HPr interaction site; other site 741091003495 glycerol kinase (GK) interaction site [polypeptide binding]; other site 741091003496 active site 741091003497 phosphorylation site [posttranslational modification] 741091003498 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 741091003499 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 741091003500 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 741091003501 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 741091003502 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 741091003503 dimerization domain swap beta strand [polypeptide binding]; other site 741091003504 regulatory protein interface [polypeptide binding]; other site 741091003505 active site 741091003506 regulatory phosphorylation site [posttranslational modification]; other site 741091003507 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 741091003508 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 741091003509 dimer interface [polypeptide binding]; other site 741091003510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091003511 catalytic residue [active] 741091003512 putative sulfate transport protein CysZ; Validated; Region: PRK04949 741091003513 cell division protein ZipA; Provisional; Region: PRK03427 741091003514 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 741091003515 FtsZ protein binding site [polypeptide binding]; other site 741091003516 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 741091003517 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 741091003518 nucleotide binding pocket [chemical binding]; other site 741091003519 K-X-D-G motif; other site 741091003520 catalytic site [active] 741091003521 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 741091003522 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 741091003523 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 741091003524 DNA binding site [nucleotide binding] 741091003525 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 741091003526 Dimer interface [polypeptide binding]; other site 741091003527 BRCT sequence motif; other site 741091003528 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 741091003529 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 741091003530 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 741091003531 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091003532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091003533 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 741091003534 putative dimerization interface [polypeptide binding]; other site 741091003535 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 741091003536 ethanolamine permease; Region: 2A0305; TIGR00908 741091003537 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 741091003538 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 741091003539 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 741091003540 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 741091003541 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 741091003542 active site 741091003543 HIGH motif; other site 741091003544 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 741091003545 active site 741091003546 KMSKS motif; other site 741091003547 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 741091003548 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 741091003549 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 741091003550 Nucleoside recognition; Region: Gate; pfam07670 741091003551 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 741091003552 manganese transport protein MntH; Reviewed; Region: PRK00701 741091003553 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 741091003554 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 741091003555 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091003556 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091003557 active site 741091003558 catalytic tetrad [active] 741091003559 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 741091003560 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 741091003561 dimer interface [polypeptide binding]; other site 741091003562 PYR/PP interface [polypeptide binding]; other site 741091003563 TPP binding site [chemical binding]; other site 741091003564 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 741091003565 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 741091003566 TPP-binding site [chemical binding]; other site 741091003567 dimer interface [polypeptide binding]; other site 741091003568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091003569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091003570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 741091003571 dimerization interface [polypeptide binding]; other site 741091003572 Predicted membrane protein [Function unknown]; Region: COG4125 741091003573 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 741091003574 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 741091003575 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 741091003576 aspartate racemase; Region: asp_race; TIGR00035 741091003577 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 741091003578 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 741091003579 Cl- selectivity filter; other site 741091003580 Cl- binding residues [ion binding]; other site 741091003581 pore gating glutamate residue; other site 741091003582 dimer interface [polypeptide binding]; other site 741091003583 glucokinase, proteobacterial type; Region: glk; TIGR00749 741091003584 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741091003585 nucleotide binding site [chemical binding]; other site 741091003586 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 741091003587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091003588 active site 741091003589 phosphorylation site [posttranslational modification] 741091003590 intermolecular recognition site; other site 741091003591 dimerization interface [polypeptide binding]; other site 741091003592 LytTr DNA-binding domain; Region: LytTR; pfam04397 741091003593 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 741091003594 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 741091003595 Histidine kinase; Region: His_kinase; pfam06580 741091003596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091003597 ATP binding site [chemical binding]; other site 741091003598 Mg2+ binding site [ion binding]; other site 741091003599 G-X-G motif; other site 741091003600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 741091003601 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 741091003602 Coenzyme A binding pocket [chemical binding]; other site 741091003603 aminotransferase; Validated; Region: PRK08175 741091003604 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091003605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091003606 homodimer interface [polypeptide binding]; other site 741091003607 catalytic residue [active] 741091003608 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091003609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091003610 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 741091003611 substrate binding site [chemical binding]; other site 741091003612 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 741091003613 SnoaL-like domain; Region: SnoaL_2; pfam12680 741091003614 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 741091003615 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 741091003616 Curli assembly protein CsgE; Region: CsgE; cl08115 741091003617 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 741091003618 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741091003619 DNA binding residues [nucleotide binding] 741091003620 dimerization interface [polypeptide binding]; other site 741091003621 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 741091003622 Curlin associated repeat; Region: Curlin_rpt; pfam07012 741091003623 Curlin associated repeat; Region: Curlin_rpt; pfam07012 741091003624 major curlin subunit; Provisional; Region: csgA; PRK10051 741091003625 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; cl11667 741091003626 High-affinity nickel-transport protein; Region: NicO; cl00964 741091003627 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 741091003628 Acylphosphatase; Region: Acylphosphatase; pfam00708 741091003629 HypF finger; Region: zf-HYPF; pfam07503 741091003630 HypF finger; Region: zf-HYPF; pfam07503 741091003631 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 741091003632 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 741091003633 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 741091003634 [4Fe-4S] binding site [ion binding]; other site 741091003635 molybdopterin cofactor binding site; other site 741091003636 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 741091003637 molybdopterin cofactor binding site; other site 741091003638 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 741091003639 4Fe-4S binding domain; Region: Fer4; cl02805 741091003640 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 741091003641 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 741091003642 nickel binding site [ion binding]; other site 741091003643 Formate hydrogenlyase maturation protein HycH; Region: HycH; pfam07450 741091003644 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 741091003645 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 741091003646 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 741091003647 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 741091003648 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 741091003649 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 741091003650 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 741091003651 NADH dehydrogenase; Region: NADHdh; cl00469 741091003652 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 741091003653 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 741091003654 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 741091003655 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; cl08095 741091003656 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 741091003657 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 741091003658 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 741091003659 HupF/HypC family; Region: HupF_HypC; cl00394 741091003660 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 741091003661 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 741091003662 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 741091003663 dimerization interface [polypeptide binding]; other site 741091003664 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 741091003665 ATP binding site [chemical binding]; other site 741091003666 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 741091003667 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 741091003668 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 741091003669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091003670 Walker A motif; other site 741091003671 ATP binding site [chemical binding]; other site 741091003672 Walker B motif; other site 741091003673 arginine finger; other site 741091003674 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 741091003675 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 741091003676 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 741091003677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091003678 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091003679 dimerization interface [polypeptide binding]; other site 741091003680 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 741091003681 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 741091003682 putative S-transferase; Provisional; Region: PRK11752 741091003683 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 741091003684 C-terminal domain interface [polypeptide binding]; other site 741091003685 GSH binding site (G-site) [chemical binding]; other site 741091003686 dimer interface [polypeptide binding]; other site 741091003687 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 741091003688 dimer interface [polypeptide binding]; other site 741091003689 N-terminal domain interface [polypeptide binding]; other site 741091003690 active site 741091003691 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741091003692 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091003693 DNA binding site [nucleotide binding] 741091003694 domain linker motif; other site 741091003695 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 741091003696 ligand binding site [chemical binding]; other site 741091003697 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 741091003698 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741091003699 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 741091003700 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 741091003701 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741091003702 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 741091003703 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741091003704 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 741091003705 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 741091003706 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 741091003707 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 741091003708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091003709 Coenzyme A binding pocket [chemical binding]; other site 741091003710 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 741091003711 lipoprotein, YaeC family; Region: TIGR00363 741091003712 Predicted ATPase [General function prediction only]; Region: COG5293 741091003713 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 741091003714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 741091003715 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 741091003716 active site 741091003717 metal binding site [ion binding]; metal-binding site 741091003718 interdomain interaction site; other site 741091003719 Domain of unknown function (DUF927); Region: DUF927; pfam06048 741091003720 integrase; Provisional; Region: int; PHA02601 741091003721 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741091003722 active site 741091003723 DNA binding site [nucleotide binding] 741091003724 Int/Topo IB signature motif; other site 741091003725 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 741091003726 integrase; Provisional; Region: PRK09692 741091003727 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 741091003728 active site 741091003729 Int/Topo IB signature motif; other site 741091003730 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 741091003731 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 741091003732 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 741091003733 Walker A/P-loop; other site 741091003734 ATP binding site [chemical binding]; other site 741091003735 Q-loop/lid; other site 741091003736 ABC transporter signature motif; other site 741091003737 Walker B; other site 741091003738 D-loop; other site 741091003739 H-loop/switch region; other site 741091003740 heme exporter protein CcmB; Region: ccmB; TIGR01190 741091003741 heme exporter protein CcmC; Region: ccmC; TIGR01191 741091003742 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 741091003743 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 741091003744 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 741091003745 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 741091003746 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 741091003747 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 741091003748 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 741091003749 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 741091003750 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 741091003751 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 741091003752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 741091003753 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 741091003754 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 741091003755 dimer interface [polypeptide binding]; other site 741091003756 active site 741091003757 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 741091003758 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 741091003759 substrate binding site [chemical binding]; other site 741091003760 oxyanion hole (OAH) forming residues; other site 741091003761 trimer interface [polypeptide binding]; other site 741091003762 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 741091003763 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 741091003764 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 741091003765 catalytic core [active] 741091003766 hypothetical protein; Provisional; Region: PRK04946 741091003767 Smr domain; Region: Smr; pfam01713 741091003768 HemK family putative methylases; Region: hemK_fam; TIGR00536 741091003769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091003770 S-adenosylmethionine binding site [chemical binding]; other site 741091003771 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 741091003772 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 741091003773 Tetramer interface [polypeptide binding]; other site 741091003774 active site 741091003775 FMN-binding site [chemical binding]; other site 741091003776 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 741091003777 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 741091003778 hypothetical protein; Provisional; Region: PRK10621 741091003779 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 741091003780 Protein of unknown function, DUF462; Region: DUF462; cl01190 741091003781 YfcL protein; Region: YfcL; pfam08891 741091003782 Uncharacterized conserved protein [Function unknown]; Region: COG4121 741091003783 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 741091003784 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741091003785 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 741091003786 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 741091003787 dimer interface [polypeptide binding]; other site 741091003788 active site 741091003789 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 741091003790 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 741091003791 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 741091003792 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 741091003793 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 741091003794 transmembrane helices; other site 741091003795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091003796 DNA-binding site [nucleotide binding]; DNA binding site 741091003797 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 741091003798 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091003799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091003800 homodimer interface [polypeptide binding]; other site 741091003801 catalytic residue [active] 741091003802 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 741091003803 active site residue [active] 741091003804 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 741091003805 EamA-like transporter family; Region: EamA; pfam00892 741091003806 Cupin domain; Region: Cupin_2; pfam07883 741091003807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091003808 Helix-turn-helix domain; Region: HTH_18; pfam12833 741091003809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091003810 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 741091003811 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 741091003812 ligand binding site [chemical binding]; other site 741091003813 NAD binding site [chemical binding]; other site 741091003814 catalytic site [active] 741091003815 homodimer interface [polypeptide binding]; other site 741091003816 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 741091003817 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 741091003818 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 741091003819 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 741091003820 dimerization interface 3.5A [polypeptide binding]; other site 741091003821 active site 741091003822 hypothetical protein; Provisional; Region: PRK10847 741091003823 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 741091003824 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 741091003825 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 741091003826 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 741091003827 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 741091003828 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 741091003829 cell division protein DedD; Provisional; Region: PRK11633 741091003830 Sporulation related domain; Region: SPOR; pfam05036 741091003831 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 741091003832 colicin V production protein; Provisional; Region: PRK10845 741091003833 amidophosphoribosyltransferase; Provisional; Region: PRK09246 741091003834 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 741091003835 active site 741091003836 tetramer interface [polypeptide binding]; other site 741091003837 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741091003838 active site 741091003839 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 741091003840 Flavoprotein; Region: Flavoprotein; pfam02441 741091003841 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 741091003842 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091003843 substrate binding pocket [chemical binding]; other site 741091003844 membrane-bound complex binding site; other site 741091003845 hinge residues; other site 741091003846 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741091003847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091003848 dimer interface [polypeptide binding]; other site 741091003849 conserved gate region; other site 741091003850 putative PBP binding loops; other site 741091003851 ABC-ATPase subunit interface; other site 741091003852 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741091003853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091003854 dimer interface [polypeptide binding]; other site 741091003855 conserved gate region; other site 741091003856 putative PBP binding loops; other site 741091003857 ABC-ATPase subunit interface; other site 741091003858 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 741091003859 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091003860 Walker A/P-loop; other site 741091003861 ATP binding site [chemical binding]; other site 741091003862 Q-loop/lid; other site 741091003863 ABC transporter signature motif; other site 741091003864 Walker B; other site 741091003865 D-loop; other site 741091003866 H-loop/switch region; other site 741091003867 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 741091003868 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 741091003869 metal binding site [ion binding]; metal-binding site 741091003870 dimer interface [polypeptide binding]; other site 741091003871 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091003872 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 741091003873 peptide binding site [polypeptide binding]; other site 741091003874 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 741091003875 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 741091003876 putative NAD(P) binding site [chemical binding]; other site 741091003877 putative active site [active] 741091003878 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 741091003879 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 741091003880 C-terminal domain interface [polypeptide binding]; other site 741091003881 GSH binding site (G-site) [chemical binding]; other site 741091003882 dimer interface [polypeptide binding]; other site 741091003883 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 741091003884 N-terminal domain interface [polypeptide binding]; other site 741091003885 putative dimer interface [polypeptide binding]; other site 741091003886 active site 741091003887 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 741091003888 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 741091003889 nudix motif; other site 741091003890 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741091003891 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091003892 DNA binding site [nucleotide binding] 741091003893 domain linker motif; other site 741091003894 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 741091003895 putative dimerization interface [polypeptide binding]; other site 741091003896 putative ligand binding site [chemical binding]; other site 741091003897 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741091003898 active site 741091003899 phosphorylation site [posttranslational modification] 741091003900 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 741091003901 active site 741091003902 P-loop; other site 741091003903 phosphorylation site [posttranslational modification] 741091003904 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 741091003905 transketolase; Reviewed; Region: PRK05899 741091003906 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 741091003907 TPP-binding site [chemical binding]; other site 741091003908 dimer interface [polypeptide binding]; other site 741091003909 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 741091003910 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 741091003911 PYR/PP interface [polypeptide binding]; other site 741091003912 dimer interface [polypeptide binding]; other site 741091003913 TPP binding site [chemical binding]; other site 741091003914 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 741091003915 phosphate acetyltransferase; Reviewed; Region: PRK05632 741091003916 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 741091003917 DRTGG domain; Region: DRTGG; pfam07085 741091003918 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 741091003919 propionate/acetate kinase; Provisional; Region: PRK12379 741091003920 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 741091003921 hypothetical protein; Provisional; Region: PRK01816 741091003922 hypothetical protein; Validated; Region: PRK05445 741091003923 putative phosphatase; Provisional; Region: PRK11587 741091003924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091003925 motif II; other site 741091003926 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 741091003927 transmembrane helices; other site 741091003928 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 741091003929 TrkA-C domain; Region: TrkA_C; pfam02080 741091003930 TrkA-C domain; Region: TrkA_C; pfam02080 741091003931 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 741091003932 5'-nucleotidase; Provisional; Region: PRK03826 741091003933 aminotransferase AlaT; Validated; Region: PRK09265 741091003934 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091003935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091003936 homodimer interface [polypeptide binding]; other site 741091003937 catalytic residue [active] 741091003938 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 741091003939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091003940 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 741091003941 putative dimerization interface [polypeptide binding]; other site 741091003942 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 741091003943 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 741091003944 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 741091003945 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 741091003946 NADH dehydrogenase subunit D; Validated; Region: PRK06075 741091003947 NADH dehydrogenase subunit E; Validated; Region: PRK07539 741091003948 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 741091003949 putative dimer interface [polypeptide binding]; other site 741091003950 [2Fe-2S] cluster binding site [ion binding]; other site 741091003951 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 741091003952 SLBB domain; Region: SLBB; pfam10531 741091003953 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 741091003954 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 741091003955 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741091003956 catalytic loop [active] 741091003957 iron binding site [ion binding]; other site 741091003958 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 741091003959 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 741091003960 [4Fe-4S] binding site [ion binding]; other site 741091003961 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 741091003962 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 741091003963 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 741091003964 4Fe-4S binding domain; Region: Fer4; pfam00037 741091003965 4Fe-4S binding domain; Region: Fer4; pfam00037 741091003966 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 741091003967 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 741091003968 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 741091003969 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 741091003970 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 741091003971 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 741091003972 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 741091003973 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 741091003974 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 741091003975 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 741091003976 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 741091003977 hypothetical protein; Provisional; Region: PRK10404 741091003978 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 741091003979 chorismate binding enzyme; Region: Chorismate_bind; cl10555 741091003980 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 741091003981 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 741091003982 dimer interface [polypeptide binding]; other site 741091003983 tetramer interface [polypeptide binding]; other site 741091003984 PYR/PP interface [polypeptide binding]; other site 741091003985 TPP binding site [chemical binding]; other site 741091003986 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 741091003987 TPP-binding site; other site 741091003988 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 741091003989 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 741091003990 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 741091003991 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 741091003992 substrate binding site [chemical binding]; other site 741091003993 oxyanion hole (OAH) forming residues; other site 741091003994 trimer interface [polypeptide binding]; other site 741091003995 O-succinylbenzoate synthase; Provisional; Region: PRK05105 741091003996 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 741091003997 active site 741091003998 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 741091003999 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 741091004000 acyl-activating enzyme (AAE) consensus motif; other site 741091004001 putative AMP binding site [chemical binding]; other site 741091004002 putative active site [active] 741091004003 putative CoA binding site [chemical binding]; other site 741091004004 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 741091004005 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 741091004006 tetramer interface [polypeptide binding]; other site 741091004007 heme binding pocket [chemical binding]; other site 741091004008 NADPH binding site [chemical binding]; other site 741091004009 YfaZ precursor; Region: YfaZ; pfam07437 741091004010 hypothetical protein; Provisional; Region: PRK03673 741091004011 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 741091004012 putative MPT binding site; other site 741091004013 Competence-damaged protein; Region: CinA; cl00666 741091004014 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 741091004015 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741091004016 catalytic loop [active] 741091004017 iron binding site [ion binding]; other site 741091004018 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 741091004019 dimer interface [polypeptide binding]; other site 741091004020 putative radical transfer pathway; other site 741091004021 diiron center [ion binding]; other site 741091004022 tyrosyl radical; other site 741091004023 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 741091004024 ATP cone domain; Region: ATP-cone; pfam03477 741091004025 Class I ribonucleotide reductase; Region: RNR_I; cd01679 741091004026 active site 741091004027 dimer interface [polypeptide binding]; other site 741091004028 catalytic residues [active] 741091004029 effector binding site; other site 741091004030 R2 peptide binding site; other site 741091004031 adhesin; Provisional; Region: PRK09752 741091004032 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 741091004033 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 741091004034 Autotransporter beta-domain; Region: Autotransporter; smart00869 741091004035 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 741091004036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091004037 S-adenosylmethionine binding site [chemical binding]; other site 741091004038 DNA gyrase subunit A; Validated; Region: PRK05560 741091004039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 741091004040 CAP-like domain; other site 741091004041 active site 741091004042 primary dimer interface [polypeptide binding]; other site 741091004043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741091004044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741091004045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741091004046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741091004047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741091004048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 741091004049 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 741091004050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091004051 dimer interface [polypeptide binding]; other site 741091004052 phosphorylation site [posttranslational modification] 741091004053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091004054 ATP binding site [chemical binding]; other site 741091004055 Mg2+ binding site [ion binding]; other site 741091004056 G-X-G motif; other site 741091004057 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 741091004058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091004059 active site 741091004060 phosphorylation site [posttranslational modification] 741091004061 intermolecular recognition site; other site 741091004062 dimerization interface [polypeptide binding]; other site 741091004063 transcriptional regulator RcsB; Provisional; Region: PRK10840 741091004064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091004065 active site 741091004066 phosphorylation site [posttranslational modification] 741091004067 intermolecular recognition site; other site 741091004068 dimerization interface [polypeptide binding]; other site 741091004069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741091004070 DNA binding residues [nucleotide binding] 741091004071 dimerization interface [polypeptide binding]; other site 741091004072 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 741091004073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091004074 ATP binding site [chemical binding]; other site 741091004075 Mg2+ binding site [ion binding]; other site 741091004076 G-X-G motif; other site 741091004077 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 741091004078 putative binding surface; other site 741091004079 active site 741091004080 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741091004081 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741091004082 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741091004083 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741091004084 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741091004085 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741091004086 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741091004087 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741091004088 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741091004089 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741091004090 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741091004091 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741091004092 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741091004093 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741091004094 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741091004095 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741091004096 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741091004097 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 741091004098 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 741091004099 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 741091004100 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 741091004101 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741091004102 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 741091004103 Walker A/P-loop; other site 741091004104 ATP binding site [chemical binding]; other site 741091004105 Q-loop/lid; other site 741091004106 ABC transporter signature motif; other site 741091004107 Walker B; other site 741091004108 D-loop; other site 741091004109 H-loop/switch region; other site 741091004110 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 741091004111 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091004112 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 741091004113 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 741091004114 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741091004115 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 741091004116 trimer interface [polypeptide binding]; other site 741091004117 eyelet of channel; other site 741091004118 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 741091004119 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091004120 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 741091004121 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 741091004122 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 741091004123 DinI-like family; Region: DinI; pfam06183 741091004124 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 741091004125 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 741091004126 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 741091004127 putative dimer interface [polypeptide binding]; other site 741091004128 N-terminal domain interface [polypeptide binding]; other site 741091004129 putative substrate binding pocket (H-site) [chemical binding]; other site 741091004130 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 741091004131 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 741091004132 Sulfatase; Region: Sulfatase; cl17466 741091004133 hypothetical protein; Provisional; Region: PRK13689 741091004134 Nucleoid-associated protein [General function prediction only]; Region: COG3081 741091004135 nucleoid-associated protein NdpA; Validated; Region: PRK00378 741091004136 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 741091004137 5S rRNA interface [nucleotide binding]; other site 741091004138 CTC domain interface [polypeptide binding]; other site 741091004139 L16 interface [polypeptide binding]; other site 741091004140 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 741091004141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741091004142 ATP binding site [chemical binding]; other site 741091004143 putative Mg++ binding site [ion binding]; other site 741091004144 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091004145 nucleotide binding region [chemical binding]; other site 741091004146 ATP-binding site [chemical binding]; other site 741091004147 Double zinc ribbon; Region: DZR; pfam12773 741091004148 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 741091004149 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741091004150 RNA binding surface [nucleotide binding]; other site 741091004151 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 741091004152 active site 741091004153 uracil binding [chemical binding]; other site 741091004154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091004155 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 741091004156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091004157 D-galactonate transporter; Region: 2A0114; TIGR00893 741091004158 putative substrate translocation pore; other site 741091004159 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 741091004160 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091004161 DNA binding site [nucleotide binding] 741091004162 domain linker motif; other site 741091004163 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 741091004164 putative ligand binding site [chemical binding]; other site 741091004165 putative dimerization interface [polypeptide binding]; other site 741091004166 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 741091004167 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 741091004168 NADP binding site [chemical binding]; other site 741091004169 homodimer interface [polypeptide binding]; other site 741091004170 active site 741091004171 classical (c) SDRs; Region: SDR_c; cd05233 741091004172 NAD(P) binding site [chemical binding]; other site 741091004173 active site 741091004174 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 741091004175 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 741091004176 Cytochrome c; Region: Cytochrom_C; pfam00034 741091004177 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 741091004178 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 741091004179 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 741091004180 hypothetical protein; Provisional; Region: PRK11835 741091004181 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 741091004182 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091004183 Walker A/P-loop; other site 741091004184 ATP binding site [chemical binding]; other site 741091004185 Q-loop/lid; other site 741091004186 ABC transporter signature motif; other site 741091004187 Walker B; other site 741091004188 D-loop; other site 741091004189 H-loop/switch region; other site 741091004190 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091004191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091004192 Walker A/P-loop; other site 741091004193 ATP binding site [chemical binding]; other site 741091004194 Q-loop/lid; other site 741091004195 ABC transporter signature motif; other site 741091004196 Walker B; other site 741091004197 D-loop; other site 741091004198 H-loop/switch region; other site 741091004199 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091004200 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 741091004201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091004202 dimer interface [polypeptide binding]; other site 741091004203 conserved gate region; other site 741091004204 ABC-ATPase subunit interface; other site 741091004205 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 741091004206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091004207 dimer interface [polypeptide binding]; other site 741091004208 conserved gate region; other site 741091004209 putative PBP binding loops; other site 741091004210 ABC-ATPase subunit interface; other site 741091004211 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 741091004212 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 741091004213 phage resistance protein; Provisional; Region: PRK10551 741091004214 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 741091004215 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091004216 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 741091004217 NlpC/P60 family; Region: NLPC_P60; pfam00877 741091004218 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 741091004219 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 741091004220 active site 741091004221 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 741091004222 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 741091004223 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 741091004224 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 741091004225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091004226 DNA-binding site [nucleotide binding]; DNA binding site 741091004227 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 741091004228 D-mannonate oxidoreductase; Provisional; Region: PRK15037 741091004229 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 741091004230 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 741091004231 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 741091004232 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741091004233 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 741091004234 elongation factor P; Provisional; Region: PRK04542 741091004235 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 741091004236 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 741091004237 RNA binding site [nucleotide binding]; other site 741091004238 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 741091004239 RNA binding site [nucleotide binding]; other site 741091004240 Flagellin N-methylase; Region: FliB; cl00497 741091004241 sugar efflux transporter B; Provisional; Region: PRK15011 741091004242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091004243 putative substrate translocation pore; other site 741091004244 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 741091004245 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741091004246 active site 741091004247 phosphorylation site [posttranslational modification] 741091004248 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 741091004249 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 741091004250 dimerization domain swap beta strand [polypeptide binding]; other site 741091004251 regulatory protein interface [polypeptide binding]; other site 741091004252 active site 741091004253 regulatory phosphorylation site [posttranslational modification]; other site 741091004254 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 741091004255 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 741091004256 putative substrate binding site [chemical binding]; other site 741091004257 putative ATP binding site [chemical binding]; other site 741091004258 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 741091004259 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 741091004260 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 741091004261 active site 741091004262 P-loop; other site 741091004263 phosphorylation site [posttranslational modification] 741091004264 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 741091004265 endonuclease IV; Provisional; Region: PRK01060 741091004266 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 741091004267 AP (apurinic/apyrimidinic) site pocket; other site 741091004268 DNA interaction; other site 741091004269 Metal-binding active site; metal-binding site 741091004270 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 741091004271 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 741091004272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091004273 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 741091004274 putative dimerization interface [polypeptide binding]; other site 741091004275 lysine transporter; Provisional; Region: PRK10836 741091004276 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 741091004277 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 741091004278 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741091004279 ABC-ATPase subunit interface; other site 741091004280 dimer interface [polypeptide binding]; other site 741091004281 putative PBP binding regions; other site 741091004282 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 741091004283 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 741091004284 Walker A/P-loop; other site 741091004285 ATP binding site [chemical binding]; other site 741091004286 Q-loop/lid; other site 741091004287 ABC transporter signature motif; other site 741091004288 Walker B; other site 741091004289 D-loop; other site 741091004290 H-loop/switch region; other site 741091004291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091004292 active site 741091004293 motif I; other site 741091004294 motif II; other site 741091004295 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741091004296 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 741091004297 trimer interface [polypeptide binding]; other site 741091004298 eyelet of channel; other site 741091004299 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 741091004300 DEAD_2; Region: DEAD_2; pfam06733 741091004301 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 741091004302 glycosyl transferase family protein; Provisional; Region: PRK08136 741091004303 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 741091004304 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 741091004305 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 741091004306 PhnA protein; Region: PhnA; pfam03831 741091004307 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 741091004308 active site 741091004309 Zn binding site [ion binding]; other site 741091004310 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 741091004311 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 741091004312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091004313 S-adenosylmethionine binding site [chemical binding]; other site 741091004314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091004315 PAS domain; Region: PAS_9; pfam13426 741091004316 putative active site [active] 741091004317 heme pocket [chemical binding]; other site 741091004318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091004319 PAS domain; Region: PAS_9; pfam13426 741091004320 putative active site [active] 741091004321 heme pocket [chemical binding]; other site 741091004322 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 741091004323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091004324 dimer interface [polypeptide binding]; other site 741091004325 putative CheW interface [polypeptide binding]; other site 741091004326 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 741091004327 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091004328 Walker A/P-loop; other site 741091004329 ATP binding site [chemical binding]; other site 741091004330 Q-loop/lid; other site 741091004331 ABC transporter signature motif; other site 741091004332 Walker B; other site 741091004333 D-loop; other site 741091004334 H-loop/switch region; other site 741091004335 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741091004336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091004337 dimer interface [polypeptide binding]; other site 741091004338 conserved gate region; other site 741091004339 putative PBP binding loops; other site 741091004340 ABC-ATPase subunit interface; other site 741091004341 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 741091004342 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091004343 substrate binding pocket [chemical binding]; other site 741091004344 membrane-bound complex binding site; other site 741091004345 hinge residues; other site 741091004346 hypothetical protein; Provisional; Region: PRK11019 741091004347 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 741091004348 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 741091004349 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 741091004350 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 741091004351 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 741091004352 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 741091004353 Right handed beta helix region; Region: Beta_helix; pfam13229 741091004354 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 741091004355 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 741091004356 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 741091004357 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 741091004358 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 741091004359 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 741091004360 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 741091004361 Walker A/P-loop; other site 741091004362 ATP binding site [chemical binding]; other site 741091004363 Q-loop/lid; other site 741091004364 ABC transporter signature motif; other site 741091004365 Walker B; other site 741091004366 D-loop; other site 741091004367 H-loop/switch region; other site 741091004368 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 741091004369 ABC-2 type transporter; Region: ABC2_membrane; cl17235 741091004370 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 741091004371 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 741091004372 dimerization interface [polypeptide binding]; other site 741091004373 DPS ferroxidase diiron center [ion binding]; other site 741091004374 ion pore; other site 741091004375 putative anti-sigmaE protein; Provisional; Region: PRK13920 741091004376 Anti-sigma-K factor rskA; Region: RskA; pfam10099 741091004377 RNA polymerase sigma factor; Provisional; Region: PRK11924 741091004378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 741091004379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741091004380 DNA binding residues [nucleotide binding] 741091004381 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 741091004382 Fasciclin domain; Region: Fasciclin; pfam02469 741091004383 threonine and homoserine efflux system; Provisional; Region: PRK10532 741091004384 EamA-like transporter family; Region: EamA; pfam00892 741091004385 outer membrane protein X; Provisional; Region: ompX; PRK09408 741091004386 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 741091004387 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 741091004388 Moco binding site; other site 741091004389 metal coordination site [ion binding]; other site 741091004390 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 741091004391 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 741091004392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091004393 active site 741091004394 phosphorylation site [posttranslational modification] 741091004395 intermolecular recognition site; other site 741091004396 dimerization interface [polypeptide binding]; other site 741091004397 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091004398 DNA binding site [nucleotide binding] 741091004399 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 741091004400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091004401 dimerization interface [polypeptide binding]; other site 741091004402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091004403 dimer interface [polypeptide binding]; other site 741091004404 phosphorylation site [posttranslational modification] 741091004405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091004406 ATP binding site [chemical binding]; other site 741091004407 Mg2+ binding site [ion binding]; other site 741091004408 G-X-G motif; other site 741091004409 phosphoethanolamine transferase; Provisional; Region: PRK11560 741091004410 Sulfatase; Region: Sulfatase; pfam00884 741091004411 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 741091004412 putative catalytic site [active] 741091004413 putative metal binding site [ion binding]; other site 741091004414 putative phosphate binding site [ion binding]; other site 741091004415 transcriptional activator TtdR; Provisional; Region: PRK09801 741091004416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091004417 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 741091004418 putative effector binding pocket; other site 741091004419 putative dimerization interface [polypeptide binding]; other site 741091004420 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 741091004421 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 741091004422 substrate binding site [chemical binding]; other site 741091004423 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 741091004424 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 741091004425 substrate binding site [chemical binding]; other site 741091004426 ligand binding site [chemical binding]; other site 741091004427 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 741091004428 choline transport protein BetT; Provisional; Region: PRK09928 741091004429 transcriptional regulator BetI; Validated; Region: PRK00767 741091004430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091004431 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 741091004432 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 741091004433 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 741091004434 tetrameric interface [polypeptide binding]; other site 741091004435 NAD binding site [chemical binding]; other site 741091004436 catalytic residues [active] 741091004437 choline dehydrogenase; Validated; Region: PRK02106 741091004438 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 741091004439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091004440 Coenzyme A binding pocket [chemical binding]; other site 741091004441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091004442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091004443 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 741091004444 putative effector binding pocket; other site 741091004445 dimerization interface [polypeptide binding]; other site 741091004446 Protein of unknown function, DUF606; Region: DUF606; pfam04657 741091004447 Protein of unknown function, DUF606; Region: DUF606; pfam04657 741091004448 RES domain; Region: RES; cl02411 741091004449 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 741091004450 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 741091004451 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 741091004452 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 741091004453 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091004454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091004455 Walker A/P-loop; other site 741091004456 ATP binding site [chemical binding]; other site 741091004457 ABC transporter signature motif; other site 741091004458 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091004459 Walker B; other site 741091004460 ABC transporter; Region: ABC_tran_2; pfam12848 741091004461 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091004462 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 741091004463 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 741091004464 ATP binding site [chemical binding]; other site 741091004465 substrate interface [chemical binding]; other site 741091004466 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 741091004467 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 741091004468 dimer interface [polypeptide binding]; other site 741091004469 putative functional site; other site 741091004470 putative MPT binding site; other site 741091004471 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 741091004472 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 741091004473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 741091004474 Transposase; Region: DEDD_Tnp_IS110; pfam01548 741091004475 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 741091004476 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 741091004477 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741091004478 Autotransporter beta-domain; Region: Autotransporter; smart00869 741091004479 putative transporter; Provisional; Region: PRK03699 741091004480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091004481 putative substrate translocation pore; other site 741091004482 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 741091004483 catalytic nucleophile [active] 741091004484 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 741091004485 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091004486 Walker A/P-loop; other site 741091004487 ATP binding site [chemical binding]; other site 741091004488 Q-loop/lid; other site 741091004489 ABC transporter signature motif; other site 741091004490 Walker B; other site 741091004491 D-loop; other site 741091004492 H-loop/switch region; other site 741091004493 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091004494 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091004495 Walker A/P-loop; other site 741091004496 ATP binding site [chemical binding]; other site 741091004497 Q-loop/lid; other site 741091004498 ABC transporter signature motif; other site 741091004499 Walker B; other site 741091004500 D-loop; other site 741091004501 H-loop/switch region; other site 741091004502 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091004503 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 741091004504 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 741091004505 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 741091004506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091004507 dimer interface [polypeptide binding]; other site 741091004508 conserved gate region; other site 741091004509 putative PBP binding loops; other site 741091004510 ABC-ATPase subunit interface; other site 741091004511 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 741091004512 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741091004513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091004514 dimer interface [polypeptide binding]; other site 741091004515 conserved gate region; other site 741091004516 putative PBP binding loops; other site 741091004517 ABC-ATPase subunit interface; other site 741091004518 S-formylglutathione hydrolase; Region: PLN02442 741091004519 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 741091004520 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 741091004521 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 741091004522 substrate binding site [chemical binding]; other site 741091004523 catalytic Zn binding site [ion binding]; other site 741091004524 NAD binding site [chemical binding]; other site 741091004525 structural Zn binding site [ion binding]; other site 741091004526 dimer interface [polypeptide binding]; other site 741091004527 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091004528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091004529 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 741091004530 putative dimerization interface [polypeptide binding]; other site 741091004531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091004532 putative substrate translocation pore; other site 741091004533 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 741091004534 active site 741091004535 Predicted membrane protein [Function unknown]; Region: COG2311 741091004536 hypothetical protein; Provisional; Region: PRK10835 741091004537 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 741091004538 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091004539 DNA binding site [nucleotide binding] 741091004540 domain linker motif; other site 741091004541 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 741091004542 dimerization interface (closed form) [polypeptide binding]; other site 741091004543 ligand binding site [chemical binding]; other site 741091004544 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 741091004545 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 741091004546 ligand binding site [chemical binding]; other site 741091004547 calcium binding site [ion binding]; other site 741091004548 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741091004549 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 741091004550 Walker A/P-loop; other site 741091004551 ATP binding site [chemical binding]; other site 741091004552 Q-loop/lid; other site 741091004553 ABC transporter signature motif; other site 741091004554 Walker B; other site 741091004555 D-loop; other site 741091004556 H-loop/switch region; other site 741091004557 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741091004558 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091004559 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091004560 TM-ABC transporter signature motif; other site 741091004561 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 741091004562 putative active site [active] 741091004563 malate dehydrogenase; Provisional; Region: PRK13529 741091004564 Malic enzyme, N-terminal domain; Region: malic; pfam00390 741091004565 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 741091004566 NAD(P) binding site [chemical binding]; other site 741091004567 cytidine deaminase; Provisional; Region: PRK09027 741091004568 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 741091004569 active site 741091004570 catalytic motif [active] 741091004571 Zn binding site [ion binding]; other site 741091004572 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 741091004573 active site 741091004574 catalytic motif [active] 741091004575 Zn binding site [ion binding]; other site 741091004576 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 741091004577 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091004578 substrate binding pocket [chemical binding]; other site 741091004579 membrane-bound complex binding site; other site 741091004580 hinge residues; other site 741091004581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091004582 dimer interface [polypeptide binding]; other site 741091004583 conserved gate region; other site 741091004584 putative PBP binding loops; other site 741091004585 ABC-ATPase subunit interface; other site 741091004586 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741091004587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091004588 dimer interface [polypeptide binding]; other site 741091004589 conserved gate region; other site 741091004590 putative PBP binding loops; other site 741091004591 ABC-ATPase subunit interface; other site 741091004592 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 741091004593 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091004594 substrate binding pocket [chemical binding]; other site 741091004595 membrane-bound complex binding site; other site 741091004596 hinge residues; other site 741091004597 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 741091004598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091004599 Walker A/P-loop; other site 741091004600 ATP binding site [chemical binding]; other site 741091004601 Q-loop/lid; other site 741091004602 ABC transporter signature motif; other site 741091004603 Walker B; other site 741091004604 D-loop; other site 741091004605 H-loop/switch region; other site 741091004606 putative lipoprotein; Provisional; Region: PRK10533 741091004607 hypothetical protein; Provisional; Region: PRK02877 741091004608 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 741091004609 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 741091004610 amidase catalytic site [active] 741091004611 Zn binding residues [ion binding]; other site 741091004612 substrate binding site [chemical binding]; other site 741091004613 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 741091004614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091004615 NAD(P) binding site [chemical binding]; other site 741091004616 active site 741091004617 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 741091004618 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 741091004619 putative NAD(P) binding site [chemical binding]; other site 741091004620 putative active site [active] 741091004621 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 741091004622 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 741091004623 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 741091004624 tetramer interface [polypeptide binding]; other site 741091004625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091004626 catalytic residue [active] 741091004627 pyruvate dehydrogenase; Provisional; Region: PRK09124 741091004628 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 741091004629 PYR/PP interface [polypeptide binding]; other site 741091004630 dimer interface [polypeptide binding]; other site 741091004631 tetramer interface [polypeptide binding]; other site 741091004632 TPP binding site [chemical binding]; other site 741091004633 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 741091004634 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 741091004635 TPP-binding site [chemical binding]; other site 741091004636 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 741091004637 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 741091004638 FAD binding pocket [chemical binding]; other site 741091004639 FAD binding motif [chemical binding]; other site 741091004640 phosphate binding motif [ion binding]; other site 741091004641 beta-alpha-beta structure motif; other site 741091004642 NAD binding pocket [chemical binding]; other site 741091004643 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741091004644 catalytic loop [active] 741091004645 iron binding site [ion binding]; other site 741091004646 hybrid cluster protein; Provisional; Region: PRK05290 741091004647 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 741091004648 ACS interaction site; other site 741091004649 CODH interaction site; other site 741091004650 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 741091004651 hybrid metal cluster; other site 741091004652 Predicted membrane protein [Function unknown]; Region: COG2431 741091004653 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 741091004654 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 741091004655 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 741091004656 putative active site [active] 741091004657 putative metal-binding site [ion binding]; other site 741091004658 Protein of unknown function (DUF535); Region: DUF535; pfam04393 741091004659 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741091004660 DNA-binding site [nucleotide binding]; DNA binding site 741091004661 RNA-binding motif; other site 741091004662 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 741091004663 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 741091004664 Clp amino terminal domain; Region: Clp_N; pfam02861 741091004665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091004666 Walker A motif; other site 741091004667 ATP binding site [chemical binding]; other site 741091004668 Walker B motif; other site 741091004669 arginine finger; other site 741091004670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091004671 Walker A motif; other site 741091004672 ATP binding site [chemical binding]; other site 741091004673 Walker B motif; other site 741091004674 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 741091004675 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 741091004676 rRNA binding site [nucleotide binding]; other site 741091004677 predicted 30S ribosome binding site; other site 741091004678 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 741091004679 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 741091004680 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741091004681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091004682 Walker A/P-loop; other site 741091004683 ATP binding site [chemical binding]; other site 741091004684 Q-loop/lid; other site 741091004685 ABC transporter signature motif; other site 741091004686 Walker B; other site 741091004687 D-loop; other site 741091004688 H-loop/switch region; other site 741091004689 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 741091004690 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741091004691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091004692 Walker A/P-loop; other site 741091004693 ATP binding site [chemical binding]; other site 741091004694 Q-loop/lid; other site 741091004695 ABC transporter signature motif; other site 741091004696 Walker B; other site 741091004697 D-loop; other site 741091004698 H-loop/switch region; other site 741091004699 thioredoxin reductase; Provisional; Region: PRK10262 741091004700 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741091004701 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741091004702 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 741091004703 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091004704 putative DNA binding site [nucleotide binding]; other site 741091004705 putative Zn2+ binding site [ion binding]; other site 741091004706 AsnC family; Region: AsnC_trans_reg; pfam01037 741091004707 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 741091004708 DNA translocase FtsK; Provisional; Region: PRK10263 741091004709 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 741091004710 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 741091004711 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 741091004712 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 741091004713 recombination factor protein RarA; Reviewed; Region: PRK13342 741091004714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091004715 Walker A motif; other site 741091004716 ATP binding site [chemical binding]; other site 741091004717 Walker B motif; other site 741091004718 arginine finger; other site 741091004719 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 741091004720 seryl-tRNA synthetase; Provisional; Region: PRK05431 741091004721 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 741091004722 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 741091004723 dimer interface [polypeptide binding]; other site 741091004724 active site 741091004725 motif 1; other site 741091004726 motif 2; other site 741091004727 motif 3; other site 741091004728 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 741091004729 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 741091004730 putative [Fe4-S4] binding site [ion binding]; other site 741091004731 putative molybdopterin cofactor binding site [chemical binding]; other site 741091004732 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 741091004733 putative molybdopterin cofactor binding site; other site 741091004734 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 741091004735 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 741091004736 putative [Fe4-S4] binding site [ion binding]; other site 741091004737 putative molybdopterin cofactor binding site [chemical binding]; other site 741091004738 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 741091004739 putative molybdopterin cofactor binding site; other site 741091004740 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 741091004741 4Fe-4S binding domain; Region: Fer4; cl02805 741091004742 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 741091004743 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 741091004744 ferredoxin-type protein NapF; Region: napF; TIGR00402 741091004745 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 741091004746 putative MFS family transporter protein; Provisional; Region: PRK03633 741091004747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091004748 putative substrate translocation pore; other site 741091004749 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 741091004750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091004751 FeS/SAM binding site; other site 741091004752 integrase; Provisional; Region: int; PHA02601 741091004753 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741091004754 active site 741091004755 DNA binding site [nucleotide binding] 741091004756 Int/Topo IB signature motif; other site 741091004757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091004758 non-specific DNA binding site [nucleotide binding]; other site 741091004759 salt bridge; other site 741091004760 sequence-specific DNA binding site [nucleotide binding]; other site 741091004761 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 741091004762 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 741091004763 DksA-like zinc finger domain containing protein; Region: PHA00080 741091004764 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 741091004765 Divergent AAA domain; Region: AAA_4; pfam04326 741091004766 portal vertex protein; Provisional; Region: Q; PHA02536 741091004767 Phage portal protein; Region: Phage_portal; pfam04860 741091004768 terminase ATPase subunit; Provisional; Region: P; PHA02535 741091004769 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 741091004770 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 741091004771 capsid protein; Provisional; Region: N; PHA02538 741091004772 terminase endonuclease subunit; Provisional; Region: M; PHA02537 741091004773 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 741091004774 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 741091004775 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 741091004776 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741091004777 catalytic residues [active] 741091004778 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 741091004779 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 741091004780 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 741091004781 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 741091004782 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 741091004783 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 741091004784 baseplate assembly protein; Provisional; Region: J; PHA02568 741091004785 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 741091004786 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 741091004787 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 741091004788 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 741091004789 major tail sheath protein; Provisional; Region: FI; PHA02560 741091004790 major tail tube protein; Provisional; Region: FII; PHA02600 741091004791 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 741091004792 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 741091004793 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 741091004794 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 741091004795 tail protein; Provisional; Region: D; PHA02561 741091004796 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 741091004797 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 741091004798 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 741091004799 Pyruvate formate lyase 1; Region: PFL1; cd01678 741091004800 coenzyme A binding site [chemical binding]; other site 741091004801 active site 741091004802 catalytic residues [active] 741091004803 glycine loop; other site 741091004804 formate transporter; Provisional; Region: PRK10805 741091004805 uncharacterized domain; Region: TIGR00702 741091004806 YcaO-like family; Region: YcaO; pfam02624 741091004807 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 741091004808 homodimer interface [polypeptide binding]; other site 741091004809 substrate-cofactor binding pocket; other site 741091004810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091004811 catalytic residue [active] 741091004812 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 741091004813 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 741091004814 hinge; other site 741091004815 active site 741091004816 cytidylate kinase; Provisional; Region: cmk; PRK00023 741091004817 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 741091004818 CMP-binding site; other site 741091004819 The sites determining sugar specificity; other site 741091004820 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 741091004821 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 741091004822 RNA binding site [nucleotide binding]; other site 741091004823 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 741091004824 RNA binding site [nucleotide binding]; other site 741091004825 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 741091004826 RNA binding site [nucleotide binding]; other site 741091004827 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 741091004828 RNA binding site [nucleotide binding]; other site 741091004829 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 741091004830 RNA binding site [nucleotide binding]; other site 741091004831 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 741091004832 RNA binding site [nucleotide binding]; other site 741091004833 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 741091004834 IHF dimer interface [polypeptide binding]; other site 741091004835 IHF - DNA interface [nucleotide binding]; other site 741091004836 ComEC family competence protein; Provisional; Region: PRK11539 741091004837 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 741091004838 Competence protein; Region: Competence; pfam03772 741091004839 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 741091004840 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 741091004841 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741091004842 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 741091004843 Walker A/P-loop; other site 741091004844 ATP binding site [chemical binding]; other site 741091004845 Q-loop/lid; other site 741091004846 ABC transporter signature motif; other site 741091004847 Walker B; other site 741091004848 D-loop; other site 741091004849 H-loop/switch region; other site 741091004850 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 741091004851 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 741091004852 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741091004853 DNA-binding site [nucleotide binding]; DNA binding site 741091004854 RNA-binding motif; other site 741091004855 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741091004856 DNA-binding site [nucleotide binding]; DNA binding site 741091004857 RNA-binding motif; other site 741091004858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 741091004859 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 741091004860 Trm112p-like protein; Region: Trm112p; cl01066 741091004861 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 741091004862 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 741091004863 Ligand binding site; other site 741091004864 oligomer interface; other site 741091004865 hypothetical protein; Provisional; Region: PRK10593 741091004866 Phosphotransferase enzyme family; Region: APH; pfam01636 741091004867 Uncharacterized conserved protein [Function unknown]; Region: COG1434 741091004868 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 741091004869 putative active site [active] 741091004870 Methyltransferase domain; Region: Methyltransf_31; pfam13847 741091004871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091004872 S-adenosylmethionine binding site [chemical binding]; other site 741091004873 condesin subunit F; Provisional; Region: PRK05260 741091004874 condesin subunit E; Provisional; Region: PRK05256 741091004875 cell division protein MukB; Provisional; Region: mukB; PRK04863 741091004876 MukB N-terminal; Region: MukB; pfam04310 741091004877 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 741091004878 murein L,D-transpeptidase; Provisional; Region: PRK10594 741091004879 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 741091004880 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 741091004881 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 741091004882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 741091004883 Peptidase M15; Region: Peptidase_M15_3; cl01194 741091004884 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 741091004885 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 741091004886 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091004887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091004888 homodimer interface [polypeptide binding]; other site 741091004889 catalytic residue [active] 741091004890 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741091004891 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 741091004892 trimer interface [polypeptide binding]; other site 741091004893 eyelet of channel; other site 741091004894 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 741091004895 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 741091004896 putative dimer interface [polypeptide binding]; other site 741091004897 putative anticodon binding site; other site 741091004898 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 741091004899 homodimer interface [polypeptide binding]; other site 741091004900 motif 1; other site 741091004901 motif 2; other site 741091004902 active site 741091004903 motif 3; other site 741091004904 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 741091004905 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 741091004906 active site 741091004907 aminopeptidase N; Provisional; Region: pepN; PRK14015 741091004908 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 741091004909 active site 741091004910 Zn binding site [ion binding]; other site 741091004911 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 741091004912 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 741091004913 Walker A/P-loop; other site 741091004914 ATP binding site [chemical binding]; other site 741091004915 Q-loop/lid; other site 741091004916 ABC transporter signature motif; other site 741091004917 Walker B; other site 741091004918 D-loop; other site 741091004919 H-loop/switch region; other site 741091004920 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 741091004921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091004922 dimer interface [polypeptide binding]; other site 741091004923 conserved gate region; other site 741091004924 putative PBP binding loops; other site 741091004925 ABC-ATPase subunit interface; other site 741091004926 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 741091004927 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 741091004928 active site 741091004929 dimer interface [polypeptide binding]; other site 741091004930 non-prolyl cis peptide bond; other site 741091004931 insertion regions; other site 741091004932 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 741091004933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091004934 substrate binding pocket [chemical binding]; other site 741091004935 membrane-bound complex binding site; other site 741091004936 hinge residues; other site 741091004937 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 741091004938 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 741091004939 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 741091004940 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 741091004941 quinone interaction residues [chemical binding]; other site 741091004942 active site 741091004943 catalytic residues [active] 741091004944 FMN binding site [chemical binding]; other site 741091004945 substrate binding site [chemical binding]; other site 741091004946 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 741091004947 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 741091004948 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 741091004949 MOSC domain; Region: MOSC; pfam03473 741091004950 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 741091004951 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741091004952 catalytic loop [active] 741091004953 iron binding site [ion binding]; other site 741091004954 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 741091004955 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 741091004956 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 741091004957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091004958 S-adenosylmethionine binding site [chemical binding]; other site 741091004959 ABC transporter ATPase component; Reviewed; Region: PRK11147 741091004960 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091004961 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091004962 ABC transporter; Region: ABC_tran_2; pfam12848 741091004963 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091004964 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 741091004965 Paraquat-inducible protein A; Region: PqiA; pfam04403 741091004966 Paraquat-inducible protein A; Region: PqiA; pfam04403 741091004967 paraquat-inducible protein B; Provisional; Region: PRK10807 741091004968 mce related protein; Region: MCE; pfam02470 741091004969 mce related protein; Region: MCE; pfam02470 741091004970 mce related protein; Region: MCE; pfam02470 741091004971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 741091004972 Protein of unknown function (DUF330); Region: DUF330; pfam03886 741091004973 ribosome modulation factor; Provisional; Region: PRK14563 741091004974 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 741091004975 active site 1 [active] 741091004976 dimer interface [polypeptide binding]; other site 741091004977 active site 2 [active] 741091004978 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 741091004979 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 741091004980 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 741091004981 outer membrane protein A; Reviewed; Region: PRK10808 741091004982 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 741091004983 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741091004984 ligand binding site [chemical binding]; other site 741091004985 SOS cell division inhibitor; Provisional; Region: PRK10595 741091004986 TfoX N-terminal domain; Region: TfoX_N; pfam04993 741091004987 TfoX C-terminal domain; Region: TfoX_C; pfam04994 741091004988 TIGR01666 family membrane protein; Region: YCCS 741091004989 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 741091004990 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 741091004991 Predicted membrane protein [Function unknown]; Region: COG3304 741091004992 Domain of unknown function (DUF307); Region: DUF307; pfam03733 741091004993 Domain of unknown function (DUF307); Region: DUF307; pfam03733 741091004994 DNA helicase IV; Provisional; Region: helD; PRK11054 741091004995 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 741091004996 Part of AAA domain; Region: AAA_19; pfam13245 741091004997 Family description; Region: UvrD_C_2; pfam13538 741091004998 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 741091004999 active site 741091005000 dimer interfaces [polypeptide binding]; other site 741091005001 catalytic residues [active] 741091005002 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 741091005003 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 741091005004 heat shock protein HspQ; Provisional; Region: PRK14129 741091005005 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 741091005006 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 741091005007 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 741091005008 putative RNA binding site [nucleotide binding]; other site 741091005009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091005010 S-adenosylmethionine binding site [chemical binding]; other site 741091005011 acylphosphatase; Provisional; Region: PRK14426 741091005012 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 741091005013 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 741091005014 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 741091005015 YccA-like proteins; Region: YccA_like; cd10433 741091005016 Cupin; Region: Cupin_6; pfam12852 741091005017 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091005018 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091005019 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091005020 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 741091005021 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 741091005022 putative NAD(P) binding site [chemical binding]; other site 741091005023 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 741091005024 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 741091005025 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 741091005026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091005027 dimer interface [polypeptide binding]; other site 741091005028 conserved gate region; other site 741091005029 ABC-ATPase subunit interface; other site 741091005030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091005031 dimer interface [polypeptide binding]; other site 741091005032 conserved gate region; other site 741091005033 putative PBP binding loops; other site 741091005034 ABC-ATPase subunit interface; other site 741091005035 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 741091005036 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 741091005037 Walker A/P-loop; other site 741091005038 ATP binding site [chemical binding]; other site 741091005039 Q-loop/lid; other site 741091005040 ABC transporter signature motif; other site 741091005041 Walker B; other site 741091005042 D-loop; other site 741091005043 H-loop/switch region; other site 741091005044 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 741091005045 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 741091005046 dimer interface [polypeptide binding]; other site 741091005047 ligand binding site [chemical binding]; other site 741091005048 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091005049 dimerization interface [polypeptide binding]; other site 741091005050 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091005051 dimer interface [polypeptide binding]; other site 741091005052 putative CheW interface [polypeptide binding]; other site 741091005053 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 741091005054 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 741091005055 potassium/proton antiporter; Reviewed; Region: PRK05326 741091005056 TrkA-C domain; Region: TrkA_C; pfam02080 741091005057 Transporter associated domain; Region: CorC_HlyC; smart01091 741091005058 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 741091005059 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 741091005060 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 741091005061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091005062 non-specific DNA binding site [nucleotide binding]; other site 741091005063 salt bridge; other site 741091005064 sequence-specific DNA binding site [nucleotide binding]; other site 741091005065 Cupin domain; Region: Cupin_2; pfam07883 741091005066 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 741091005067 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 741091005068 catalytic triad [active] 741091005069 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 741091005070 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 741091005071 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 741091005072 exonuclease I; Provisional; Region: sbcB; PRK11779 741091005073 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 741091005074 active site 741091005075 catalytic site [active] 741091005076 substrate binding site [chemical binding]; other site 741091005077 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 741091005078 Predicted membrane protein [Function unknown]; Region: COG1289 741091005079 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 741091005080 hypothetical protein; Provisional; Region: PRK05423 741091005081 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 741091005082 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 741091005083 dimerization interface [polypeptide binding]; other site 741091005084 NAD binding site [chemical binding]; other site 741091005085 ligand binding site [chemical binding]; other site 741091005086 catalytic site [active] 741091005087 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 741091005088 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 741091005089 Walker A/P-loop; other site 741091005090 ATP binding site [chemical binding]; other site 741091005091 Q-loop/lid; other site 741091005092 ABC transporter signature motif; other site 741091005093 Walker B; other site 741091005094 D-loop; other site 741091005095 H-loop/switch region; other site 741091005096 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 741091005097 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 741091005098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091005099 dimer interface [polypeptide binding]; other site 741091005100 conserved gate region; other site 741091005101 ABC-ATPase subunit interface; other site 741091005102 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741091005103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091005104 dimer interface [polypeptide binding]; other site 741091005105 conserved gate region; other site 741091005106 putative PBP binding loops; other site 741091005107 ABC-ATPase subunit interface; other site 741091005108 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 741091005109 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 741091005110 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 741091005111 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 741091005112 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 741091005113 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741091005114 active site turn [active] 741091005115 phosphorylation site [posttranslational modification] 741091005116 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 741091005117 trimer interface; other site 741091005118 sugar binding site [chemical binding]; other site 741091005119 lac repressor; Reviewed; Region: lacI; PRK09526 741091005120 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091005121 DNA binding site [nucleotide binding] 741091005122 domain linker motif; other site 741091005123 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 741091005124 ligand binding site [chemical binding]; other site 741091005125 dimerization interface (open form) [polypeptide binding]; other site 741091005126 dimerization interface (closed form) [polypeptide binding]; other site 741091005127 Protein of unknown function (DUF805); Region: DUF805; pfam05656 741091005128 Serine hydrolase; Region: Ser_hydrolase; pfam06821 741091005129 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 741091005130 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 741091005131 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 741091005132 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 741091005133 citrate lyase subunit gamma; Provisional; Region: PRK13253 741091005134 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 741091005135 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 741091005136 putative active site [active] 741091005137 (T/H)XGH motif; other site 741091005138 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 741091005139 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 741091005140 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 741091005141 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 741091005142 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091005143 putative active site [active] 741091005144 heme pocket [chemical binding]; other site 741091005145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091005146 ATP binding site [chemical binding]; other site 741091005147 Mg2+ binding site [ion binding]; other site 741091005148 G-X-G motif; other site 741091005149 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 741091005150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091005151 active site 741091005152 phosphorylation site [posttranslational modification] 741091005153 intermolecular recognition site; other site 741091005154 dimerization interface [polypeptide binding]; other site 741091005155 Transcriptional regulator; Region: CitT; pfam12431 741091005156 MATE family multidrug exporter; Provisional; Region: PRK10189 741091005157 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 741091005158 AMP nucleosidase; Provisional; Region: PRK08292 741091005159 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 741091005160 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 741091005161 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 741091005162 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 741091005163 putative C-terminal domain interface [polypeptide binding]; other site 741091005164 putative GSH binding site (G-site) [chemical binding]; other site 741091005165 putative dimer interface [polypeptide binding]; other site 741091005166 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 741091005167 putative N-terminal domain interface [polypeptide binding]; other site 741091005168 putative dimer interface [polypeptide binding]; other site 741091005169 putative substrate binding pocket (H-site) [chemical binding]; other site 741091005170 shikimate transporter; Provisional; Region: PRK09952 741091005171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091005172 putative substrate translocation pore; other site 741091005173 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 741091005174 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 741091005175 active site 741091005176 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091005177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091005178 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 741091005179 putative effector binding pocket; other site 741091005180 putative dimerization interface [polypeptide binding]; other site 741091005181 short chain dehydrogenase; Provisional; Region: PRK12744 741091005182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091005183 NAD(P) binding site [chemical binding]; other site 741091005184 active site 741091005185 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741091005186 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091005187 DNA binding site [nucleotide binding] 741091005188 domain linker motif; other site 741091005189 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 741091005190 putative dimerization interface [polypeptide binding]; other site 741091005191 putative ligand binding site [chemical binding]; other site 741091005192 galactoside permease; Reviewed; Region: lacY; PRK09528 741091005193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091005194 putative substrate translocation pore; other site 741091005195 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 741091005196 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 741091005197 substrate binding [chemical binding]; other site 741091005198 active site 741091005199 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 741091005200 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 741091005201 MltA-interacting protein MipA; Region: MipA; cl01504 741091005202 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 741091005203 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091005204 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 741091005205 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 741091005206 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 741091005207 active site 741091005208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091005209 putative substrate translocation pore; other site 741091005210 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091005211 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091005212 LysR substrate binding domain; Region: LysR_substrate; pfam03466 741091005213 dimerization interface [polypeptide binding]; other site 741091005214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091005215 Coenzyme A binding pocket [chemical binding]; other site 741091005216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091005217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091005218 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 741091005219 putative effector binding pocket; other site 741091005220 putative dimerization interface [polypeptide binding]; other site 741091005221 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 741091005222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091005223 putative substrate translocation pore; other site 741091005224 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 741091005225 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741091005226 Uncharacterized conserved protein [Function unknown]; Region: COG4925 741091005227 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091005228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091005229 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 741091005230 putative effector binding pocket; other site 741091005231 dimerization interface [polypeptide binding]; other site 741091005232 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 741091005233 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 741091005234 NAD(P) binding site [chemical binding]; other site 741091005235 active site 741091005236 Transcriptional regulators [Transcription]; Region: MarR; COG1846 741091005237 MarR family; Region: MarR; pfam01047 741091005238 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 741091005239 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 741091005240 putative NAD(P) binding site [chemical binding]; other site 741091005241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091005242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091005243 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091005244 dimerization interface [polypeptide binding]; other site 741091005245 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 741091005246 YCII-related domain; Region: YCII; cl00999 741091005247 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 741091005248 Uncharacterized conserved protein [Function unknown]; Region: COG1359 741091005249 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 741091005250 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 741091005251 Chorismate mutase type II; Region: CM_2; smart00830 741091005252 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 741091005253 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 741091005254 TMP-binding site; other site 741091005255 ATP-binding site [chemical binding]; other site 741091005256 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 741091005257 catalytic residues [active] 741091005258 dimer interface [polypeptide binding]; other site 741091005259 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 741091005260 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 741091005261 Walker A/P-loop; other site 741091005262 ATP binding site [chemical binding]; other site 741091005263 Q-loop/lid; other site 741091005264 ABC transporter signature motif; other site 741091005265 Walker B; other site 741091005266 D-loop; other site 741091005267 H-loop/switch region; other site 741091005268 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 741091005269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091005270 dimer interface [polypeptide binding]; other site 741091005271 conserved gate region; other site 741091005272 putative PBP binding loops; other site 741091005273 ABC-ATPase subunit interface; other site 741091005274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091005275 dimer interface [polypeptide binding]; other site 741091005276 conserved gate region; other site 741091005277 putative PBP binding loops; other site 741091005278 ABC-ATPase subunit interface; other site 741091005279 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 741091005280 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 741091005281 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091005282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091005283 metal binding site [ion binding]; metal-binding site 741091005284 active site 741091005285 I-site; other site 741091005286 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 741091005287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091005288 non-specific DNA binding site [nucleotide binding]; other site 741091005289 salt bridge; other site 741091005290 sequence-specific DNA binding site [nucleotide binding]; other site 741091005291 Cupin domain; Region: Cupin_2; pfam07883 741091005292 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 741091005293 B3/4 domain; Region: B3_4; pfam03483 741091005294 Transcriptional regulators [Transcription]; Region: FadR; COG2186 741091005295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091005296 DNA-binding site [nucleotide binding]; DNA binding site 741091005297 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 741091005298 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091005299 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 741091005300 Walker A/P-loop; other site 741091005301 ATP binding site [chemical binding]; other site 741091005302 Q-loop/lid; other site 741091005303 ABC transporter signature motif; other site 741091005304 Walker B; other site 741091005305 D-loop; other site 741091005306 H-loop/switch region; other site 741091005307 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091005308 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091005309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091005310 dimer interface [polypeptide binding]; other site 741091005311 conserved gate region; other site 741091005312 putative PBP binding loops; other site 741091005313 ABC-ATPase subunit interface; other site 741091005314 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 741091005315 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091005316 Walker A/P-loop; other site 741091005317 ATP binding site [chemical binding]; other site 741091005318 Q-loop/lid; other site 741091005319 ABC transporter signature motif; other site 741091005320 Walker B; other site 741091005321 D-loop; other site 741091005322 H-loop/switch region; other site 741091005323 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091005324 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091005325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091005326 dimer interface [polypeptide binding]; other site 741091005327 conserved gate region; other site 741091005328 putative PBP binding loops; other site 741091005329 ABC-ATPase subunit interface; other site 741091005330 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091005331 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 741091005332 peptide binding site [polypeptide binding]; other site 741091005333 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 741091005334 aspartate aminotransferase; Provisional; Region: PRK05764 741091005335 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091005336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091005337 homodimer interface [polypeptide binding]; other site 741091005338 catalytic residue [active] 741091005339 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 741091005340 conserved cys residue [active] 741091005341 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 741091005342 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 741091005343 inhibitor site; inhibition site 741091005344 active site 741091005345 dimer interface [polypeptide binding]; other site 741091005346 catalytic residue [active] 741091005347 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 741091005348 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 741091005349 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 741091005350 active site 741091005351 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 741091005352 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 741091005353 metal binding site [ion binding]; metal-binding site 741091005354 substrate binding pocket [chemical binding]; other site 741091005355 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 741091005356 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 741091005357 metal binding site [ion binding]; metal-binding site 741091005358 dimer interface [polypeptide binding]; other site 741091005359 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741091005360 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091005361 Walker A/P-loop; other site 741091005362 ATP binding site [chemical binding]; other site 741091005363 Q-loop/lid; other site 741091005364 ABC transporter signature motif; other site 741091005365 Walker B; other site 741091005366 D-loop; other site 741091005367 H-loop/switch region; other site 741091005368 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741091005369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091005370 dimer interface [polypeptide binding]; other site 741091005371 conserved gate region; other site 741091005372 putative PBP binding loops; other site 741091005373 ABC-ATPase subunit interface; other site 741091005374 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091005375 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 741091005376 substrate binding pocket [chemical binding]; other site 741091005377 membrane-bound complex binding site; other site 741091005378 hinge residues; other site 741091005379 Transcriptional regulators [Transcription]; Region: GntR; COG1802 741091005380 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091005381 DNA-binding site [nucleotide binding]; DNA binding site 741091005382 Transcriptional regulators [Transcription]; Region: FadR; COG2186 741091005383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 741091005384 DNA-binding site [nucleotide binding]; DNA binding site 741091005385 FCD domain; Region: FCD; pfam07729 741091005386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091005387 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 741091005388 NAD(P) binding site [chemical binding]; other site 741091005389 active site 741091005390 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 741091005391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091005392 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 741091005393 putative dimerization interface [polypeptide binding]; other site 741091005394 Uncharacterized small protein [Function unknown]; Region: COG2879 741091005395 carbon starvation protein A; Provisional; Region: PRK15015 741091005396 Carbon starvation protein CstA; Region: CstA; pfam02554 741091005397 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 741091005398 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 741091005399 dimer interface [polypeptide binding]; other site 741091005400 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 741091005401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091005402 DNA-binding site [nucleotide binding]; DNA binding site 741091005403 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091005404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091005405 homodimer interface [polypeptide binding]; other site 741091005406 catalytic residue [active] 741091005407 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 741091005408 putative active site [active] 741091005409 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 741091005410 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 741091005411 N- and C-terminal domain interface [polypeptide binding]; other site 741091005412 active site 741091005413 MgATP binding site [chemical binding]; other site 741091005414 catalytic site [active] 741091005415 metal binding site [ion binding]; metal-binding site 741091005416 carbohydrate binding site [chemical binding]; other site 741091005417 putative homodimer interface [polypeptide binding]; other site 741091005418 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091005419 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091005420 TM-ABC transporter signature motif; other site 741091005421 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091005422 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091005423 TM-ABC transporter signature motif; other site 741091005424 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 741091005425 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741091005426 Walker A/P-loop; other site 741091005427 ATP binding site [chemical binding]; other site 741091005428 Q-loop/lid; other site 741091005429 ABC transporter signature motif; other site 741091005430 Walker B; other site 741091005431 D-loop; other site 741091005432 H-loop/switch region; other site 741091005433 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741091005434 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 741091005435 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 741091005436 ligand binding site [chemical binding]; other site 741091005437 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 741091005438 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741091005439 inhibitor-cofactor binding pocket; inhibition site 741091005440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091005441 catalytic residue [active] 741091005442 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 741091005443 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 741091005444 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 741091005445 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 741091005446 NAD(P) binding site [chemical binding]; other site 741091005447 catalytic residues [active] 741091005448 succinylarginine dihydrolase; Provisional; Region: PRK13281 741091005449 succinylglutamate desuccinylase; Provisional; Region: PRK05324 741091005450 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 741091005451 active site 741091005452 Zn binding site [ion binding]; other site 741091005453 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 741091005454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091005455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091005456 putative substrate translocation pore; other site 741091005457 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 741091005458 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 741091005459 putative ligand binding site [chemical binding]; other site 741091005460 NAD binding site [chemical binding]; other site 741091005461 dimerization interface [polypeptide binding]; other site 741091005462 catalytic site [active] 741091005463 putative hydrolase; Validated; Region: PRK09248 741091005464 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 741091005465 active site 741091005466 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 741091005467 lipoprotein; Provisional; Region: PRK10598 741091005468 glutaredoxin 2; Provisional; Region: PRK10387 741091005469 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 741091005470 C-terminal domain interface [polypeptide binding]; other site 741091005471 GSH binding site (G-site) [chemical binding]; other site 741091005472 catalytic residues [active] 741091005473 putative dimer interface [polypeptide binding]; other site 741091005474 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 741091005475 N-terminal domain interface [polypeptide binding]; other site 741091005476 multidrug resistance protein MdtH; Provisional; Region: PRK11646 741091005477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091005478 putative substrate translocation pore; other site 741091005479 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 741091005480 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 741091005481 hypothetical protein; Provisional; Region: PRK11239 741091005482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 741091005483 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 741091005484 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741091005485 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 741091005486 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 741091005487 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 741091005488 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 741091005489 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 741091005490 active site 741091005491 HIGH motif; other site 741091005492 KMSK motif region; other site 741091005493 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 741091005494 tRNA binding surface [nucleotide binding]; other site 741091005495 anticodon binding site; other site 741091005496 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 741091005497 putative metal binding site [ion binding]; other site 741091005498 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 741091005499 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091005500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091005501 homodimer interface [polypeptide binding]; other site 741091005502 catalytic residue [active] 741091005503 copper homeostasis protein CutC; Provisional; Region: PRK11572 741091005504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091005505 S-adenosylmethionine binding site [chemical binding]; other site 741091005506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091005507 S-adenosylmethionine binding site [chemical binding]; other site 741091005508 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 741091005509 Protein of unknown function DUF72; Region: DUF72; cl00777 741091005510 Isochorismatase family; Region: Isochorismatase; pfam00857 741091005511 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 741091005512 catalytic triad [active] 741091005513 conserved cis-peptide bond; other site 741091005514 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 741091005515 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 741091005516 dimer interface [polypeptide binding]; other site 741091005517 anticodon binding site; other site 741091005518 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 741091005519 homodimer interface [polypeptide binding]; other site 741091005520 motif 1; other site 741091005521 active site 741091005522 motif 2; other site 741091005523 GAD domain; Region: GAD; pfam02938 741091005524 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 741091005525 active site 741091005526 motif 3; other site 741091005527 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 741091005528 nudix motif; other site 741091005529 hypothetical protein; Validated; Region: PRK00110 741091005530 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 741091005531 active site 741091005532 putative DNA-binding cleft [nucleotide binding]; other site 741091005533 dimer interface [polypeptide binding]; other site 741091005534 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 741091005535 RuvA N terminal domain; Region: RuvA_N; pfam01330 741091005536 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 741091005537 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 741091005538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091005539 Walker A motif; other site 741091005540 ATP binding site [chemical binding]; other site 741091005541 Walker B motif; other site 741091005542 arginine finger; other site 741091005543 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 741091005544 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 741091005545 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741091005546 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 741091005547 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 741091005548 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 741091005549 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 741091005550 putative symporter YagG; Provisional; Region: PRK09669 741091005551 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 741091005552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091005553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091005554 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 741091005555 putative effector binding pocket; other site 741091005556 putative dimerization interface [polypeptide binding]; other site 741091005557 short chain dehydrogenase; Provisional; Region: PRK06172 741091005558 classical (c) SDRs; Region: SDR_c; cd05233 741091005559 NAD(P) binding site [chemical binding]; other site 741091005560 active site 741091005561 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 741091005562 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741091005563 active site turn [active] 741091005564 phosphorylation site [posttranslational modification] 741091005565 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741091005566 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 741091005567 HPr interaction site; other site 741091005568 glycerol kinase (GK) interaction site [polypeptide binding]; other site 741091005569 active site 741091005570 phosphorylation site [posttranslational modification] 741091005571 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 741091005572 beta-galactosidase; Region: BGL; TIGR03356 741091005573 transcriptional antiterminator BglG; Provisional; Region: PRK09772 741091005574 CAT RNA binding domain; Region: CAT_RBD; smart01061 741091005575 PRD domain; Region: PRD; pfam00874 741091005576 PRD domain; Region: PRD; pfam00874 741091005577 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 741091005578 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 741091005579 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 741091005580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091005581 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 741091005582 NAD(P) binding site [chemical binding]; other site 741091005583 active site 741091005584 Predicted transcriptional regulators [Transcription]; Region: COG1733 741091005585 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 741091005586 Predicted acyl esterases [General function prediction only]; Region: COG2936 741091005587 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741091005588 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741091005589 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 741091005590 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 741091005591 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091005592 Walker A/P-loop; other site 741091005593 ATP binding site [chemical binding]; other site 741091005594 Q-loop/lid; other site 741091005595 ABC transporter signature motif; other site 741091005596 Walker B; other site 741091005597 D-loop; other site 741091005598 H-loop/switch region; other site 741091005599 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091005600 Walker A/P-loop; other site 741091005601 ATP binding site [chemical binding]; other site 741091005602 Q-loop/lid; other site 741091005603 ABC transporter signature motif; other site 741091005604 Walker B; other site 741091005605 D-loop; other site 741091005606 H-loop/switch region; other site 741091005607 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091005608 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091005609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091005610 dimer interface [polypeptide binding]; other site 741091005611 conserved gate region; other site 741091005612 putative PBP binding loops; other site 741091005613 ABC-ATPase subunit interface; other site 741091005614 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091005615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091005616 dimer interface [polypeptide binding]; other site 741091005617 conserved gate region; other site 741091005618 ABC-ATPase subunit interface; other site 741091005619 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091005620 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 741091005621 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 741091005622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091005623 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091005624 dimerization interface [polypeptide binding]; other site 741091005625 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 741091005626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091005627 DNA-binding site [nucleotide binding]; DNA binding site 741091005628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091005629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091005630 homodimer interface [polypeptide binding]; other site 741091005631 catalytic residue [active] 741091005632 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 741091005633 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 741091005634 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 741091005635 active site 741091005636 HIGH motif; other site 741091005637 KMSKS motif; other site 741091005638 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 741091005639 tRNA binding surface [nucleotide binding]; other site 741091005640 anticodon binding site; other site 741091005641 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 741091005642 dimer interface [polypeptide binding]; other site 741091005643 putative tRNA-binding site [nucleotide binding]; other site 741091005644 antiporter inner membrane protein; Provisional; Region: PRK11670 741091005645 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 741091005646 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 741091005647 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 741091005648 ATP-binding site [chemical binding]; other site 741091005649 Sugar specificity; other site 741091005650 Pyrimidine base specificity; other site 741091005651 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 741091005652 trimer interface [polypeptide binding]; other site 741091005653 active site 741091005654 putative assembly protein; Provisional; Region: PRK10833 741091005655 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 741091005656 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 741091005657 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 741091005658 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 741091005659 Transporter associated domain; Region: CorC_HlyC; smart01091 741091005660 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 741091005661 active site 741091005662 tetramer interface; other site 741091005663 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 741091005664 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 741091005665 NAD binding site [chemical binding]; other site 741091005666 substrate binding site [chemical binding]; other site 741091005667 homodimer interface [polypeptide binding]; other site 741091005668 active site 741091005669 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 741091005670 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 741091005671 substrate binding site; other site 741091005672 tetramer interface; other site 741091005673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091005674 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 741091005675 NAD(P) binding site [chemical binding]; other site 741091005676 active site 741091005677 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 741091005678 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 741091005679 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 741091005680 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 741091005681 Walker A/P-loop; other site 741091005682 ATP binding site [chemical binding]; other site 741091005683 Q-loop/lid; other site 741091005684 ABC transporter signature motif; other site 741091005685 Walker B; other site 741091005686 D-loop; other site 741091005687 H-loop/switch region; other site 741091005688 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 741091005689 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 741091005690 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 741091005691 Ligand binding site; other site 741091005692 metal-binding site 741091005693 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 741091005694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 741091005695 UDP-galactopyranose mutase; Region: GLF; pfam03275 741091005696 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 741091005697 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 741091005698 active site 741091005699 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 741091005700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 741091005701 putative ADP-binding pocket [chemical binding]; other site 741091005702 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 741091005703 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 741091005704 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 741091005705 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 741091005706 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 741091005707 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 741091005708 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 741091005709 metal binding site [ion binding]; metal-binding site 741091005710 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 741091005711 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 741091005712 substrate binding site [chemical binding]; other site 741091005713 glutamase interaction surface [polypeptide binding]; other site 741091005714 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 741091005715 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 741091005716 catalytic residues [active] 741091005717 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 741091005718 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 741091005719 putative active site [active] 741091005720 oxyanion strand; other site 741091005721 catalytic triad [active] 741091005722 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 741091005723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091005724 active site 741091005725 motif I; other site 741091005726 motif II; other site 741091005727 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 741091005728 putative active site pocket [active] 741091005729 4-fold oligomerization interface [polypeptide binding]; other site 741091005730 metal binding residues [ion binding]; metal-binding site 741091005731 3-fold/trimer interface [polypeptide binding]; other site 741091005732 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 741091005733 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091005734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091005735 homodimer interface [polypeptide binding]; other site 741091005736 catalytic residue [active] 741091005737 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 741091005738 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 741091005739 NAD binding site [chemical binding]; other site 741091005740 dimerization interface [polypeptide binding]; other site 741091005741 product binding site; other site 741091005742 substrate binding site [chemical binding]; other site 741091005743 zinc binding site [ion binding]; other site 741091005744 catalytic residues [active] 741091005745 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 741091005746 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 741091005747 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 741091005748 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 741091005749 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 741091005750 putative NAD(P) binding site [chemical binding]; other site 741091005751 transcriptional activator FlhD; Provisional; Region: PRK02909 741091005752 transcriptional activator FlhC; Provisional; Region: PRK12722 741091005753 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 741091005754 flagellar motor protein MotA; Validated; Region: PRK09110 741091005755 flagellar motor protein MotB; Validated; Region: motB; PRK09041 741091005756 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 741091005757 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741091005758 ligand binding site [chemical binding]; other site 741091005759 chemotaxis protein CheA; Provisional; Region: PRK10547 741091005760 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 741091005761 putative binding surface; other site 741091005762 active site 741091005763 CheY binding; Region: CheY-binding; pfam09078 741091005764 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 741091005765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091005766 ATP binding site [chemical binding]; other site 741091005767 Mg2+ binding site [ion binding]; other site 741091005768 G-X-G motif; other site 741091005769 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 741091005770 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 741091005771 putative CheA interaction surface; other site 741091005772 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 741091005773 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741091005774 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 741091005775 dimer interface [polypeptide binding]; other site 741091005776 active site 741091005777 Int/Topo IB signature motif; other site 741091005778 Excisionase-like protein; Region: Exc; pfam07825 741091005779 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 741091005780 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 741091005781 tellurite resistance protein terB; Region: terB; cd07176 741091005782 putative metal binding site [ion binding]; other site 741091005783 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 741091005784 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 741091005785 Catalytic site [active] 741091005786 Helix-turn-helix domain; Region: HTH_36; pfam13730 741091005787 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 741091005788 MT-A70; Region: MT-A70; cl01947 741091005789 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 741091005790 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 741091005791 cofactor binding site; other site 741091005792 DNA binding site [nucleotide binding] 741091005793 substrate interaction site [chemical binding]; other site 741091005794 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 741091005795 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 741091005796 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 741091005797 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 741091005798 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 741091005799 active site 741091005800 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 741091005801 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741091005802 catalytic residues [active] 741091005803 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 741091005804 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 741091005805 active site 741091005806 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 741091005807 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 741091005808 active site 741091005809 Phage terminase, small subunit; Region: Terminase_4; cl01525 741091005810 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 741091005811 Phage-related protein [Function unknown]; Region: COG4695 741091005812 Phage portal protein; Region: Phage_portal; pfam04860 741091005813 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 741091005814 oligomer interface [polypeptide binding]; other site 741091005815 active site residues [active] 741091005816 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 741091005817 Phage capsid family; Region: Phage_capsid; pfam05065 741091005818 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 741091005819 oligomerization interface [polypeptide binding]; other site 741091005820 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 741091005821 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 741091005822 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 741091005823 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 741091005824 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 741091005825 Phage-related minor tail protein [Function unknown]; Region: COG5281 741091005826 tape measure domain; Region: tape_meas_nterm; TIGR02675 741091005827 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 741091005828 Protein of unknown function (DUF1635); Region: DUF1635; pfam07795 741091005829 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 741091005830 Phage minor tail protein; Region: Phage_min_tail; pfam05939 741091005831 Phage minor tail protein L; Region: Phage_tail_L; cl01908 741091005832 Phage minor tail protein L; Region: Phage_tail_L; cl01908 741091005833 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 741091005834 MPN+ (JAMM) motif; other site 741091005835 Zinc-binding site [ion binding]; other site 741091005836 NlpC/P60 family; Region: NLPC_P60; pfam00877 741091005837 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741091005838 Phage-related protein, tail component [Function unknown]; Region: COG4723 741091005839 Phage-related protein, tail component [Function unknown]; Region: COG4733 741091005840 Putative phage tail protein; Region: Phage-tail_3; pfam13550 741091005841 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 741091005842 Interdomain contacts; other site 741091005843 Cytokine receptor motif; other site 741091005844 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 741091005845 variable surface protein Vir12; Provisional; Region: PTZ00234 741091005846 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 741091005847 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 741091005848 OpgC protein; Region: OpgC_C; cl17858 741091005849 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 741091005850 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 741091005851 conserved cys residue [active] 741091005852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091005853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091005854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091005855 putative substrate translocation pore; other site 741091005856 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 741091005857 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 741091005858 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 741091005859 dimer interface [polypeptide binding]; other site 741091005860 ligand binding site [chemical binding]; other site 741091005861 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091005862 dimerization interface [polypeptide binding]; other site 741091005863 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091005864 dimer interface [polypeptide binding]; other site 741091005865 putative CheW interface [polypeptide binding]; other site 741091005866 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 741091005867 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 741091005868 dimer interface [polypeptide binding]; other site 741091005869 ligand binding site [chemical binding]; other site 741091005870 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 741091005871 dimerization interface [polypeptide binding]; other site 741091005872 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091005873 dimer interface [polypeptide binding]; other site 741091005874 putative CheW interface [polypeptide binding]; other site 741091005875 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 741091005876 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 741091005877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091005878 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 741091005879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091005880 active site 741091005881 phosphorylation site [posttranslational modification] 741091005882 intermolecular recognition site; other site 741091005883 dimerization interface [polypeptide binding]; other site 741091005884 CheB methylesterase; Region: CheB_methylest; pfam01339 741091005885 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 741091005886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091005887 active site 741091005888 phosphorylation site [posttranslational modification] 741091005889 intermolecular recognition site; other site 741091005890 dimerization interface [polypeptide binding]; other site 741091005891 chemotaxis regulator CheZ; Provisional; Region: PRK11166 741091005892 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 741091005893 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 741091005894 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 741091005895 FHIPEP family; Region: FHIPEP; pfam00771 741091005896 Flagellar protein FlhE; Region: FlhE; pfam06366 741091005897 FlgN protein; Region: FlgN; cl09176 741091005898 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 741091005899 SAF-like; Region: SAF_2; pfam13144 741091005900 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 741091005901 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 741091005902 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 741091005903 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 741091005904 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 741091005905 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 741091005906 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 741091005907 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 741091005908 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 741091005909 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 741091005910 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 741091005911 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 741091005912 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 741091005913 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 741091005914 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 741091005915 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 741091005916 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 741091005917 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 741091005918 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 741091005919 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 741091005920 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 741091005921 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 741091005922 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 741091005923 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 741091005924 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 741091005925 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 741091005926 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 741091005927 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 741091005928 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 741091005929 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 741091005930 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 741091005931 hypothetical protein; Provisional; Region: PRK10711 741091005932 hypothetical protein; Provisional; Region: PRK01821 741091005933 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741091005934 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091005935 Walker A/P-loop; other site 741091005936 ATP binding site [chemical binding]; other site 741091005937 Q-loop/lid; other site 741091005938 ABC transporter signature motif; other site 741091005939 Walker B; other site 741091005940 D-loop; other site 741091005941 H-loop/switch region; other site 741091005942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091005943 dimer interface [polypeptide binding]; other site 741091005944 conserved gate region; other site 741091005945 putative PBP binding loops; other site 741091005946 ABC-ATPase subunit interface; other site 741091005947 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 741091005948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091005949 Coenzyme A binding pocket [chemical binding]; other site 741091005950 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 741091005951 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091005952 substrate binding pocket [chemical binding]; other site 741091005953 membrane-bound complex binding site; other site 741091005954 hinge residues; other site 741091005955 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 741091005956 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 741091005957 metal binding site [ion binding]; metal-binding site 741091005958 dimer interface [polypeptide binding]; other site 741091005959 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 741091005960 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 741091005961 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 741091005962 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 741091005963 active site 741091005964 non-prolyl cis peptide bond; other site 741091005965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091005966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091005967 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 741091005968 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 741091005969 NADP binding site [chemical binding]; other site 741091005970 dimer interface [polypeptide binding]; other site 741091005971 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 741091005972 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 741091005973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091005974 active site 741091005975 phosphorylation site [posttranslational modification] 741091005976 intermolecular recognition site; other site 741091005977 dimerization interface [polypeptide binding]; other site 741091005978 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 741091005979 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 741091005980 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 741091005981 active site 741091005982 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 741091005983 Acyltransferase family; Region: Acyl_transf_3; pfam01757 741091005984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091005985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091005986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091005987 dimerization interface [polypeptide binding]; other site 741091005988 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 741091005989 2-methylcitrate dehydratase; Region: prpD; TIGR02330 741091005990 Phosphotransferase enzyme family; Region: APH; pfam01636 741091005991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091005992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741091005993 putative substrate translocation pore; other site 741091005994 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 741091005995 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091005996 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091005997 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 741091005998 Fusaric acid resistance protein family; Region: FUSC; pfam04632 741091005999 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 741091006000 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 741091006001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091006002 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 741091006003 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 741091006004 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 741091006005 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 741091006006 heme binding site [chemical binding]; other site 741091006007 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 741091006008 heme binding site [chemical binding]; other site 741091006009 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 741091006010 FAD binding domain; Region: FAD_binding_4; pfam01565 741091006011 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 741091006012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091006013 dimer interface [polypeptide binding]; other site 741091006014 conserved gate region; other site 741091006015 putative PBP binding loops; other site 741091006016 ABC-ATPase subunit interface; other site 741091006017 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 741091006018 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 741091006019 Walker A/P-loop; other site 741091006020 ATP binding site [chemical binding]; other site 741091006021 Q-loop/lid; other site 741091006022 ABC transporter signature motif; other site 741091006023 Walker B; other site 741091006024 D-loop; other site 741091006025 H-loop/switch region; other site 741091006026 NMT1/THI5 like; Region: NMT1; pfam09084 741091006027 Creatinine amidohydrolase; Region: Creatininase; pfam02633 741091006028 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 741091006029 homotrimer interaction site [polypeptide binding]; other site 741091006030 putative active site [active] 741091006031 cytosine deaminase-like protein; Validated; Region: PRK07583 741091006032 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 741091006033 active site 741091006034 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 741091006035 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 741091006036 FMN-binding pocket [chemical binding]; other site 741091006037 flavin binding motif; other site 741091006038 phosphate binding motif [ion binding]; other site 741091006039 beta-alpha-beta structure motif; other site 741091006040 NAD binding pocket [chemical binding]; other site 741091006041 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741091006042 catalytic loop [active] 741091006043 iron binding site [ion binding]; other site 741091006044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091006045 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091006046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091006047 dimerization interface [polypeptide binding]; other site 741091006048 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 741091006049 amidohydrolase; Provisional; Region: PRK12393 741091006050 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 741091006051 active site 741091006052 putative substrate binding pocket [chemical binding]; other site 741091006053 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 741091006054 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 741091006055 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 741091006056 Putative motility protein; Region: YjfB_motility; pfam14070 741091006057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 741091006058 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741091006059 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 741091006060 substrate binding site [chemical binding]; other site 741091006061 ATP binding site [chemical binding]; other site 741091006062 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 741091006063 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 741091006064 putative active site [active] 741091006065 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 741091006066 dimer interface [polypeptide binding]; other site 741091006067 active site 741091006068 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 741091006069 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091006070 substrate binding pocket [chemical binding]; other site 741091006071 membrane-bound complex binding site; other site 741091006072 hinge residues; other site 741091006073 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 741091006074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091006075 DNA-binding site [nucleotide binding]; DNA binding site 741091006076 UTRA domain; Region: UTRA; pfam07702 741091006077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091006078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091006079 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 741091006080 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 741091006081 FMN binding site [chemical binding]; other site 741091006082 active site 741091006083 substrate binding site [chemical binding]; other site 741091006084 catalytic residue [active] 741091006085 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 741091006086 classical (c) SDRs; Region: SDR_c; cd05233 741091006087 NAD(P) binding site [chemical binding]; other site 741091006088 active site 741091006089 short chain dehydrogenase; Provisional; Region: PRK06179 741091006090 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 741091006091 NADP binding site [chemical binding]; other site 741091006092 active site 741091006093 steroid binding site; other site 741091006094 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 741091006095 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 741091006096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091006097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091006098 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 741091006099 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 741091006100 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091006101 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091006102 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 741091006103 short chain dehydrogenase; Provisional; Region: PRK06500 741091006104 classical (c) SDRs; Region: SDR_c; cd05233 741091006105 NAD(P) binding site [chemical binding]; other site 741091006106 active site 741091006107 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 741091006108 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 741091006109 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091006110 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 741091006111 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 741091006112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091006113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091006114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091006115 dimerization interface [polypeptide binding]; other site 741091006116 putative metal dependent hydrolase; Provisional; Region: PRK11598 741091006117 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 741091006118 Sulfatase; Region: Sulfatase; pfam00884 741091006119 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 741091006120 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 741091006121 putative trimer interface [polypeptide binding]; other site 741091006122 putative CoA binding site [chemical binding]; other site 741091006123 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 741091006124 Predicted membrane protein [Function unknown]; Region: COG3817 741091006125 Protein of unknown function (DUF979); Region: DUF979; pfam06166 741091006126 Protein of unknown function (DUF969); Region: DUF969; pfam06149 741091006127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 741091006128 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 741091006129 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 741091006130 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 741091006131 putative NAD(P) binding site [chemical binding]; other site 741091006132 putative substrate binding site [chemical binding]; other site 741091006133 catalytic Zn binding site [ion binding]; other site 741091006134 structural Zn binding site [ion binding]; other site 741091006135 dimer interface [polypeptide binding]; other site 741091006136 Ion transport protein; Region: Ion_trans; pfam00520 741091006137 Ion channel; Region: Ion_trans_2; pfam07885 741091006138 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741091006139 DNA-binding site [nucleotide binding]; DNA binding site 741091006140 RNA-binding motif; other site 741091006141 hypothetical protein; Provisional; Region: PRK10708 741091006142 Tar ligand binding domain homologue; Region: TarH; pfam02203 741091006143 dimer interface [polypeptide binding]; other site 741091006144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091006145 dimerization interface [polypeptide binding]; other site 741091006146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091006147 dimer interface [polypeptide binding]; other site 741091006148 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 741091006149 putative CheW interface [polypeptide binding]; other site 741091006150 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 741091006151 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741091006152 DNA binding residues [nucleotide binding] 741091006153 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 741091006154 galactoside permease; Reviewed; Region: lacY; PRK09528 741091006155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091006156 putative substrate translocation pore; other site 741091006157 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 741091006158 Cupin domain; Region: Cupin_2; pfam07883 741091006159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091006160 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091006161 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091006162 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 741091006163 CoA-transferase family III; Region: CoA_transf_3; pfam02515 741091006164 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 741091006165 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 741091006166 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 741091006167 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 741091006168 dimer interface [polypeptide binding]; other site 741091006169 active site 741091006170 metal binding site [ion binding]; metal-binding site 741091006171 Predicted membrane protein [Function unknown]; Region: COG2733 741091006172 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091006173 dimerization interface [polypeptide binding]; other site 741091006174 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 741091006175 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 741091006176 Walker A/P-loop; other site 741091006177 ATP binding site [chemical binding]; other site 741091006178 Q-loop/lid; other site 741091006179 ABC transporter signature motif; other site 741091006180 Walker B; other site 741091006181 D-loop; other site 741091006182 H-loop/switch region; other site 741091006183 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 741091006184 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 741091006185 Mechanosensitive ion channel; Region: MS_channel; pfam00924 741091006186 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 741091006187 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 741091006188 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091006189 Outer membrane efflux protein; Region: OEP; pfam02321 741091006190 Outer membrane efflux protein; Region: OEP; pfam02321 741091006191 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 741091006192 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 741091006193 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 741091006194 oligomer interface [polypeptide binding]; other site 741091006195 metal binding site [ion binding]; metal-binding site 741091006196 metal binding site [ion binding]; metal-binding site 741091006197 putative Cl binding site [ion binding]; other site 741091006198 basic sphincter; other site 741091006199 hydrophobic gate; other site 741091006200 periplasmic entrance; other site 741091006201 short chain dehydrogenase; Provisional; Region: PRK06180 741091006202 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 741091006203 NADP binding site [chemical binding]; other site 741091006204 active site 741091006205 steroid binding site; other site 741091006206 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 741091006207 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 741091006208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091006209 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 741091006210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091006211 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 741091006212 putative substrate translocation pore; other site 741091006213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091006214 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 741091006215 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091006216 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091006217 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 741091006218 Cation efflux family; Region: Cation_efflux; cl00316 741091006219 alkaline phosphatase; Provisional; Region: PRK10518 741091006220 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 741091006221 dimer interface [polypeptide binding]; other site 741091006222 active site 741091006223 L,D-transpeptidase; Provisional; Region: PRK10260 741091006224 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 741091006225 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 741091006226 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 741091006227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091006228 putative substrate translocation pore; other site 741091006229 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 741091006230 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091006231 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091006232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091006233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091006234 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 741091006235 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741091006236 N-terminal plug; other site 741091006237 ligand-binding site [chemical binding]; other site 741091006238 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 741091006239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091006240 S-adenosylmethionine binding site [chemical binding]; other site 741091006241 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 741091006242 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 741091006243 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 741091006244 Chromate transporter; Region: Chromate_transp; pfam02417 741091006245 Chromate transporter; Region: Chromate_transp; pfam02417 741091006246 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091006247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091006248 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 741091006249 putative dimerization interface [polypeptide binding]; other site 741091006250 putative substrate binding pocket [chemical binding]; other site 741091006251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091006252 dimerization interface [polypeptide binding]; other site 741091006253 putative DNA binding site [nucleotide binding]; other site 741091006254 putative Zn2+ binding site [ion binding]; other site 741091006255 elongation factor G; Reviewed; Region: PRK00007 741091006256 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 741091006257 G1 box; other site 741091006258 putative GEF interaction site [polypeptide binding]; other site 741091006259 GTP/Mg2+ binding site [chemical binding]; other site 741091006260 Switch I region; other site 741091006261 G2 box; other site 741091006262 G3 box; other site 741091006263 Switch II region; other site 741091006264 G4 box; other site 741091006265 G5 box; other site 741091006266 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 741091006267 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 741091006268 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 741091006269 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 741091006270 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 741091006271 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 741091006272 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 741091006273 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 741091006274 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 741091006275 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 741091006276 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 741091006277 YadA-like C-terminal region; Region: YadA; pfam03895 741091006278 EthD domain; Region: EthD; cl17553 741091006279 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 741091006280 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 741091006281 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 741091006282 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741091006283 ABC-ATPase subunit interface; other site 741091006284 dimer interface [polypeptide binding]; other site 741091006285 putative PBP binding regions; other site 741091006286 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 741091006287 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 741091006288 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 741091006289 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 741091006290 metal binding site [ion binding]; metal-binding site 741091006291 putative peptidase; Provisional; Region: PRK11649 741091006292 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 741091006293 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741091006294 Peptidase family M23; Region: Peptidase_M23; pfam01551 741091006295 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 741091006296 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 741091006297 putative acyl-acceptor binding pocket; other site 741091006298 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 741091006299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091006300 putative substrate translocation pore; other site 741091006301 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 741091006302 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 741091006303 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 741091006304 IucA / IucC family; Region: IucA_IucC; pfam04183 741091006305 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 741091006306 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 741091006307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741091006308 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 741091006309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091006310 catalytic residue [active] 741091006311 pyruvate kinase; Provisional; Region: PRK05826 741091006312 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 741091006313 domain interfaces; other site 741091006314 active site 741091006315 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 741091006316 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741091006317 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 741091006318 putative active site [active] 741091006319 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 741091006320 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 741091006321 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 741091006322 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 741091006323 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 741091006324 active site 741091006325 intersubunit interface [polypeptide binding]; other site 741091006326 catalytic residue [active] 741091006327 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 741091006328 homotrimer interaction site [polypeptide binding]; other site 741091006329 putative active site [active] 741091006330 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 741091006331 DEAD/DEAH box helicase; Region: DEAD; pfam00270 741091006332 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 741091006333 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 741091006334 Glycoprotease family; Region: Peptidase_M22; pfam00814 741091006335 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 741091006336 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 741091006337 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 741091006338 acyl-activating enzyme (AAE) consensus motif; other site 741091006339 putative AMP binding site [chemical binding]; other site 741091006340 putative active site [active] 741091006341 putative CoA binding site [chemical binding]; other site 741091006342 ribonuclease D; Provisional; Region: PRK10829 741091006343 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 741091006344 catalytic site [active] 741091006345 putative active site [active] 741091006346 putative substrate binding site [chemical binding]; other site 741091006347 HRDC domain; Region: HRDC; pfam00570 741091006348 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 741091006349 cell division inhibitor MinD; Provisional; Region: PRK10818 741091006350 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 741091006351 Switch I; other site 741091006352 Switch II; other site 741091006353 septum formation inhibitor; Reviewed; Region: minC; PRK03511 741091006354 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 741091006355 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 741091006356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 741091006357 lytic murein transglycosylase; Region: MltB_2; TIGR02283 741091006358 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741091006359 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741091006360 hypothetical protein; Provisional; Region: PRK10691 741091006361 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 741091006362 hypothetical protein; Provisional; Region: PRK05170 741091006363 anti-RssB factor; Provisional; Region: PRK10244 741091006364 Domain of unknown function DUF20; Region: UPF0118; pfam01594 741091006365 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 741091006366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 741091006367 Transposase; Region: DEDD_Tnp_IS110; pfam01548 741091006368 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 741091006369 disulfide bond formation protein B; Provisional; Region: PRK01749 741091006370 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 741091006371 fatty acid metabolism regulator; Provisional; Region: PRK04984 741091006372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091006373 DNA-binding site [nucleotide binding]; DNA binding site 741091006374 FadR C-terminal domain; Region: FadR_C; pfam07840 741091006375 SpoVR family protein; Provisional; Region: PRK11767 741091006376 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 741091006377 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 741091006378 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741091006379 YdfZ protein; Region: YdfZ; cl11878 741091006380 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 741091006381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 741091006382 alanine racemase; Reviewed; Region: dadX; PRK03646 741091006383 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 741091006384 active site 741091006385 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 741091006386 substrate binding site [chemical binding]; other site 741091006387 catalytic residues [active] 741091006388 dimer interface [polypeptide binding]; other site 741091006389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091006390 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 741091006391 putative substrate translocation pore; other site 741091006392 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 741091006393 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 741091006394 homodimer interface [polypeptide binding]; other site 741091006395 NAD binding pocket [chemical binding]; other site 741091006396 ATP binding pocket [chemical binding]; other site 741091006397 Mg binding site [ion binding]; other site 741091006398 active-site loop [active] 741091006399 Protein of unknown function, DUF481; Region: DUF481; cl01213 741091006400 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 741091006401 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 741091006402 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 741091006403 haemagglutination activity domain; Region: Haemagg_act; pfam05860 741091006404 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 741091006405 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 741091006406 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 741091006407 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 741091006408 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 741091006409 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 741091006410 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 741091006411 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 741091006412 Disulfide bond isomerase protein N-terminus; Region: DsbC_N; pfam10411 741091006413 hypothetical protein; Provisional; Region: PRK05325 741091006414 PrkA family serine protein kinase; Provisional; Region: PRK15455 741091006415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091006416 Walker A motif; other site 741091006417 ATP binding site [chemical binding]; other site 741091006418 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 741091006419 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 741091006420 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091006421 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091006422 active site 741091006423 catalytic tetrad [active] 741091006424 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 741091006425 active site 741091006426 phosphate binding residues; other site 741091006427 catalytic residues [active] 741091006428 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 741091006429 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 741091006430 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 741091006431 methionine sulfoxide reductase B; Provisional; Region: PRK00222 741091006432 SelR domain; Region: SelR; pfam01641 741091006433 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 741091006434 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 741091006435 Isochorismatase family; Region: Isochorismatase; pfam00857 741091006436 catalytic triad [active] 741091006437 metal binding site [ion binding]; metal-binding site 741091006438 conserved cis-peptide bond; other site 741091006439 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 741091006440 active site 741091006441 homodimer interface [polypeptide binding]; other site 741091006442 protease 4; Provisional; Region: PRK10949 741091006443 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 741091006444 tandem repeat interface [polypeptide binding]; other site 741091006445 oligomer interface [polypeptide binding]; other site 741091006446 active site residues [active] 741091006447 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 741091006448 tandem repeat interface [polypeptide binding]; other site 741091006449 oligomer interface [polypeptide binding]; other site 741091006450 active site residues [active] 741091006451 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 741091006452 putative FMN binding site [chemical binding]; other site 741091006453 DNA topoisomerase III; Provisional; Region: PRK07726 741091006454 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 741091006455 active site 741091006456 putative interdomain interaction site [polypeptide binding]; other site 741091006457 putative metal-binding site [ion binding]; other site 741091006458 putative nucleotide binding site [chemical binding]; other site 741091006459 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 741091006460 domain I; other site 741091006461 DNA binding groove [nucleotide binding] 741091006462 phosphate binding site [ion binding]; other site 741091006463 domain II; other site 741091006464 domain III; other site 741091006465 nucleotide binding site [chemical binding]; other site 741091006466 catalytic site [active] 741091006467 domain IV; other site 741091006468 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 741091006469 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 741091006470 active site 741091006471 8-oxo-dGMP binding site [chemical binding]; other site 741091006472 nudix motif; other site 741091006473 metal binding site [ion binding]; metal-binding site 741091006474 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 741091006475 putative catalytic site [active] 741091006476 putative phosphate binding site [ion binding]; other site 741091006477 active site 741091006478 metal binding site A [ion binding]; metal-binding site 741091006479 DNA binding site [nucleotide binding] 741091006480 putative AP binding site [nucleotide binding]; other site 741091006481 putative metal binding site B [ion binding]; other site 741091006482 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 741091006483 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 741091006484 PAS domain; Region: PAS; smart00091 741091006485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091006486 Walker A motif; other site 741091006487 ATP binding site [chemical binding]; other site 741091006488 Walker B motif; other site 741091006489 arginine finger; other site 741091006490 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 741091006491 dimer interface [polypeptide binding]; other site 741091006492 catalytic triad [active] 741091006493 peroxidatic and resolving cysteines [active] 741091006494 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 741091006495 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 741091006496 active site 741091006497 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 741091006498 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 741091006499 peptide binding site [polypeptide binding]; other site 741091006500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091006501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741091006502 putative substrate translocation pore; other site 741091006503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091006504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091006505 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 741091006506 putative effector binding pocket; other site 741091006507 dimerization interface [polypeptide binding]; other site 741091006508 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 741091006509 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 741091006510 Cl binding site [ion binding]; other site 741091006511 oligomer interface [polypeptide binding]; other site 741091006512 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 741091006513 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 741091006514 Ligand Binding Site [chemical binding]; other site 741091006515 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 741091006516 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 741091006517 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 741091006518 Na binding site [ion binding]; other site 741091006519 Alginate lyase; Region: Alginate_lyase; pfam05426 741091006520 active site 741091006521 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 741091006522 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 741091006523 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 741091006524 classical (c) SDRs; Region: SDR_c; cd05233 741091006525 NAD(P) binding site [chemical binding]; other site 741091006526 active site 741091006527 Transcriptional regulators [Transcription]; Region: FadR; COG2186 741091006528 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091006529 DNA-binding site [nucleotide binding]; DNA binding site 741091006530 FCD domain; Region: FCD; pfam07729 741091006531 transcriptional activator RhaS; Provisional; Region: PRK13503 741091006532 Cupin domain; Region: Cupin_2; cl17218 741091006533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091006534 benzoate transport; Region: 2A0115; TIGR00895 741091006535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091006536 putative substrate translocation pore; other site 741091006537 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 741091006538 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 741091006539 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 741091006540 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 741091006541 dimer interface [polypeptide binding]; other site 741091006542 PYR/PP interface [polypeptide binding]; other site 741091006543 TPP binding site [chemical binding]; other site 741091006544 substrate binding site [chemical binding]; other site 741091006545 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 741091006546 Domain of unknown function; Region: EKR; smart00890 741091006547 4Fe-4S binding domain; Region: Fer4_6; pfam12837 741091006548 4Fe-4S binding domain; Region: Fer4; pfam00037 741091006549 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 741091006550 TPP-binding site [chemical binding]; other site 741091006551 dimer interface [polypeptide binding]; other site 741091006552 Domain of unknown function (DUF333); Region: DUF333; pfam03891 741091006553 META domain; Region: META; cl01245 741091006554 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 741091006555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091006556 Walker A/P-loop; other site 741091006557 ATP binding site [chemical binding]; other site 741091006558 Q-loop/lid; other site 741091006559 ABC transporter signature motif; other site 741091006560 Walker B; other site 741091006561 D-loop; other site 741091006562 H-loop/switch region; other site 741091006563 TOBE domain; Region: TOBE_2; pfam08402 741091006564 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 741091006565 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 741091006566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091006567 dimer interface [polypeptide binding]; other site 741091006568 conserved gate region; other site 741091006569 putative PBP binding loops; other site 741091006570 ABC-ATPase subunit interface; other site 741091006571 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741091006572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091006573 dimer interface [polypeptide binding]; other site 741091006574 conserved gate region; other site 741091006575 putative PBP binding loops; other site 741091006576 ABC-ATPase subunit interface; other site 741091006577 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 741091006578 active site 741091006579 metal binding site [ion binding]; metal-binding site 741091006580 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741091006581 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 741091006582 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 741091006583 putative ligand binding site [chemical binding]; other site 741091006584 putative NAD binding site [chemical binding]; other site 741091006585 catalytic site [active] 741091006586 hypothetical protein; Provisional; Region: PRK10695 741091006587 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 741091006588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 741091006589 azoreductase; Reviewed; Region: PRK00170 741091006590 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 741091006591 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 741091006592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741091006593 ATP binding site [chemical binding]; other site 741091006594 putative Mg++ binding site [ion binding]; other site 741091006595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091006596 nucleotide binding region [chemical binding]; other site 741091006597 ATP-binding site [chemical binding]; other site 741091006598 Helicase associated domain (HA2); Region: HA2; pfam04408 741091006599 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 741091006600 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 741091006601 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 741091006602 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 741091006603 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 741091006604 active site 741091006605 Zn binding site [ion binding]; other site 741091006606 sensor protein RstB; Provisional; Region: PRK10604 741091006607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091006608 dimerization interface [polypeptide binding]; other site 741091006609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091006610 dimer interface [polypeptide binding]; other site 741091006611 phosphorylation site [posttranslational modification] 741091006612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091006613 ATP binding site [chemical binding]; other site 741091006614 Mg2+ binding site [ion binding]; other site 741091006615 G-X-G motif; other site 741091006616 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 741091006617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091006618 active site 741091006619 phosphorylation site [posttranslational modification] 741091006620 intermolecular recognition site; other site 741091006621 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091006622 DNA binding site [nucleotide binding] 741091006623 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 741091006624 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 741091006625 Cytochrome c; Region: Cytochrom_C; pfam00034 741091006626 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 741091006627 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 741091006628 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 741091006629 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 741091006630 transcriptional regulator NarL; Provisional; Region: PRK10651 741091006631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091006632 active site 741091006633 phosphorylation site [posttranslational modification] 741091006634 intermolecular recognition site; other site 741091006635 dimerization interface [polypeptide binding]; other site 741091006636 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741091006637 DNA binding residues [nucleotide binding] 741091006638 dimerization interface [polypeptide binding]; other site 741091006639 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 741091006640 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 741091006641 HAMP domain; Region: HAMP; pfam00672 741091006642 Histidine kinase; Region: HisKA_3; pfam07730 741091006643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091006644 ATP binding site [chemical binding]; other site 741091006645 Mg2+ binding site [ion binding]; other site 741091006646 G-X-G motif; other site 741091006647 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 741091006648 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 741091006649 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741091006650 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 741091006651 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 741091006652 putative metal binding site [ion binding]; other site 741091006653 putative homodimer interface [polypeptide binding]; other site 741091006654 putative homotetramer interface [polypeptide binding]; other site 741091006655 putative homodimer-homodimer interface [polypeptide binding]; other site 741091006656 putative allosteric switch controlling residues; other site 741091006657 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 741091006658 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 741091006659 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 741091006660 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091006661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091006662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 741091006663 dimerization interface [polypeptide binding]; other site 741091006664 hypothetical protein; Provisional; Region: PRK11667 741091006665 endonuclease III; Provisional; Region: PRK10702 741091006666 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 741091006667 minor groove reading motif; other site 741091006668 helix-hairpin-helix signature motif; other site 741091006669 substrate binding pocket [chemical binding]; other site 741091006670 active site 741091006671 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 741091006672 electron transport complex RsxE subunit; Provisional; Region: PRK12405 741091006673 electron transport complex protein RnfG; Validated; Region: PRK01908 741091006674 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 741091006675 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 741091006676 SLBB domain; Region: SLBB; pfam10531 741091006677 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 741091006678 electron transport complex protein RnfB; Provisional; Region: PRK05113 741091006679 Putative Fe-S cluster; Region: FeS; cl17515 741091006680 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 741091006681 electron transport complex protein RsxA; Provisional; Region: PRK05151 741091006682 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 741091006683 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 741091006684 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 741091006685 hypothetical protein; Provisional; Region: PRK06185 741091006686 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 741091006687 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 741091006688 Transcriptional regulators [Transcription]; Region: FadR; COG2186 741091006689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091006690 DNA-binding site [nucleotide binding]; DNA binding site 741091006691 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 741091006692 hypothetical protein; Provisional; Region: PRK05968 741091006693 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 741091006694 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741091006695 catalytic residue [active] 741091006696 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 741091006697 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 741091006698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091006699 dimer interface [polypeptide binding]; other site 741091006700 conserved gate region; other site 741091006701 putative PBP binding loops; other site 741091006702 ABC-ATPase subunit interface; other site 741091006703 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741091006704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091006705 dimer interface [polypeptide binding]; other site 741091006706 conserved gate region; other site 741091006707 putative PBP binding loops; other site 741091006708 ABC-ATPase subunit interface; other site 741091006709 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 741091006710 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 741091006711 Walker A/P-loop; other site 741091006712 ATP binding site [chemical binding]; other site 741091006713 Q-loop/lid; other site 741091006714 ABC transporter signature motif; other site 741091006715 Walker B; other site 741091006716 D-loop; other site 741091006717 H-loop/switch region; other site 741091006718 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 741091006719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091006720 putative substrate translocation pore; other site 741091006721 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091006722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091006723 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 741091006724 dimerization interface [polypeptide binding]; other site 741091006725 substrate binding pocket [chemical binding]; other site 741091006726 MarR family; Region: MarR_2; cl17246 741091006727 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 741091006728 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741091006729 nucleotide binding site [chemical binding]; other site 741091006730 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 741091006731 AAA domain; Region: AAA_26; pfam13500 741091006732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091006733 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741091006734 putative substrate translocation pore; other site 741091006735 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 741091006736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091006737 dimer interface [polypeptide binding]; other site 741091006738 conserved gate region; other site 741091006739 putative PBP binding loops; other site 741091006740 ABC-ATPase subunit interface; other site 741091006741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091006742 dimer interface [polypeptide binding]; other site 741091006743 conserved gate region; other site 741091006744 putative PBP binding loops; other site 741091006745 ABC-ATPase subunit interface; other site 741091006746 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 741091006747 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 741091006748 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741091006749 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 741091006750 Walker A/P-loop; other site 741091006751 ATP binding site [chemical binding]; other site 741091006752 Q-loop/lid; other site 741091006753 ABC transporter signature motif; other site 741091006754 Walker B; other site 741091006755 D-loop; other site 741091006756 H-loop/switch region; other site 741091006757 L-arabinose isomerase; Provisional; Region: PRK02929 741091006758 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 741091006759 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 741091006760 trimer interface [polypeptide binding]; other site 741091006761 putative substrate binding site [chemical binding]; other site 741091006762 putative metal binding site [ion binding]; other site 741091006763 ribulokinase; Provisional; Region: PRK04123 741091006764 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 741091006765 N- and C-terminal domain interface [polypeptide binding]; other site 741091006766 active site 741091006767 MgATP binding site [chemical binding]; other site 741091006768 catalytic site [active] 741091006769 metal binding site [ion binding]; metal-binding site 741091006770 carbohydrate binding site [chemical binding]; other site 741091006771 homodimer interface [polypeptide binding]; other site 741091006772 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 741091006773 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 741091006774 ligand binding site [chemical binding]; other site 741091006775 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 741091006776 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741091006777 Walker A/P-loop; other site 741091006778 ATP binding site [chemical binding]; other site 741091006779 Q-loop/lid; other site 741091006780 ABC transporter signature motif; other site 741091006781 Walker B; other site 741091006782 D-loop; other site 741091006783 H-loop/switch region; other site 741091006784 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741091006785 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091006786 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091006787 TM-ABC transporter signature motif; other site 741091006788 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 741091006789 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 741091006790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091006791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091006792 mannonate dehydratase; Provisional; Region: PRK03906 741091006793 mannonate dehydratase; Region: uxuA; TIGR00695 741091006794 Transcriptional regulators [Transcription]; Region: FadR; COG2186 741091006795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091006796 DNA-binding site [nucleotide binding]; DNA binding site 741091006797 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 741091006798 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 741091006799 Protein of unknown function (DUF2636); Region: DUF2636; cl11897 741091006800 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 741091006801 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 741091006802 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 741091006803 YhjQ protein; Region: YhjQ; pfam06564 741091006804 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 741091006805 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 741091006806 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 741091006807 DXD motif; other site 741091006808 PilZ domain; Region: PilZ; pfam07238 741091006809 cellulose synthase regulator protein; Provisional; Region: PRK11114 741091006810 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 741091006811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741091006812 TPR motif; other site 741091006813 binding surface 741091006814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741091006815 binding surface 741091006816 TPR motif; other site 741091006817 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 741091006818 N-formylglutamate amidohydrolase; Region: FGase; cl01522 741091006819 imidazolonepropionase; Validated; Region: PRK09356 741091006820 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 741091006821 active site 741091006822 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 741091006823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091006824 DNA-binding site [nucleotide binding]; DNA binding site 741091006825 UTRA domain; Region: UTRA; pfam07702 741091006826 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 741091006827 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 741091006828 active site 741091006829 HutD; Region: HutD; pfam05962 741091006830 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 741091006831 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091006832 substrate binding pocket [chemical binding]; other site 741091006833 membrane-bound complex binding site; other site 741091006834 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 741091006835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091006836 dimer interface [polypeptide binding]; other site 741091006837 conserved gate region; other site 741091006838 putative PBP binding loops; other site 741091006839 ABC-ATPase subunit interface; other site 741091006840 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 741091006841 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 741091006842 Walker A/P-loop; other site 741091006843 ATP binding site [chemical binding]; other site 741091006844 Q-loop/lid; other site 741091006845 ABC transporter signature motif; other site 741091006846 Walker B; other site 741091006847 D-loop; other site 741091006848 H-loop/switch region; other site 741091006849 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 741091006850 active sites [active] 741091006851 tetramer interface [polypeptide binding]; other site 741091006852 urocanate hydratase; Provisional; Region: PRK05414 741091006853 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166 741091006854 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091006855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091006856 homodimer interface [polypeptide binding]; other site 741091006857 catalytic residue [active] 741091006858 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 741091006859 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 741091006860 phosphate binding site [ion binding]; other site 741091006861 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 741091006862 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 741091006863 active site 741091006864 NAD binding site [chemical binding]; other site 741091006865 metal binding site [ion binding]; metal-binding site 741091006866 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 741091006867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091006868 NAD(P) binding site [chemical binding]; other site 741091006869 active site 741091006870 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 741091006871 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 741091006872 NAD binding site [chemical binding]; other site 741091006873 dimerization interface [polypeptide binding]; other site 741091006874 product binding site; other site 741091006875 substrate binding site [chemical binding]; other site 741091006876 zinc binding site [ion binding]; other site 741091006877 catalytic residues [active] 741091006878 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 741091006879 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 741091006880 Walker A/P-loop; other site 741091006881 ATP binding site [chemical binding]; other site 741091006882 Q-loop/lid; other site 741091006883 ABC transporter signature motif; other site 741091006884 Walker B; other site 741091006885 D-loop; other site 741091006886 H-loop/switch region; other site 741091006887 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 741091006888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091006889 dimer interface [polypeptide binding]; other site 741091006890 conserved gate region; other site 741091006891 putative PBP binding loops; other site 741091006892 ABC-ATPase subunit interface; other site 741091006893 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 741091006894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091006895 substrate binding pocket [chemical binding]; other site 741091006896 membrane-bound complex binding site; other site 741091006897 hinge residues; other site 741091006898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091006899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091006900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 741091006901 dimerization interface [polypeptide binding]; other site 741091006902 argininosuccinate lyase; Provisional; Region: PRK00855 741091006903 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 741091006904 active sites [active] 741091006905 tetramer interface [polypeptide binding]; other site 741091006906 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741091006907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091006908 dimer interface [polypeptide binding]; other site 741091006909 conserved gate region; other site 741091006910 putative PBP binding loops; other site 741091006911 ABC-ATPase subunit interface; other site 741091006912 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741091006913 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091006914 Walker A/P-loop; other site 741091006915 ATP binding site [chemical binding]; other site 741091006916 Q-loop/lid; other site 741091006917 ABC transporter signature motif; other site 741091006918 Walker B; other site 741091006919 D-loop; other site 741091006920 H-loop/switch region; other site 741091006921 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 741091006922 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091006923 substrate binding pocket [chemical binding]; other site 741091006924 membrane-bound complex binding site; other site 741091006925 hinge residues; other site 741091006926 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 741091006927 active site 741091006928 catalytic site [active] 741091006929 Zn binding site [ion binding]; other site 741091006930 tetramer interface [polypeptide binding]; other site 741091006931 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 741091006932 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 741091006933 active site 741091006934 catalytic site [active] 741091006935 Zn binding site [ion binding]; other site 741091006936 tetramer interface [polypeptide binding]; other site 741091006937 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 741091006938 putative oxidoreductase; Provisional; Region: PRK11579 741091006939 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741091006940 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 741091006941 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 741091006942 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 741091006943 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 741091006944 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 741091006945 active site 741091006946 purine riboside binding site [chemical binding]; other site 741091006947 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 741091006948 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091006949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091006950 homodimer interface [polypeptide binding]; other site 741091006951 catalytic residue [active] 741091006952 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 741091006953 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 741091006954 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741091006955 active site turn [active] 741091006956 phosphorylation site [posttranslational modification] 741091006957 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 741091006958 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091006959 DNA binding site [nucleotide binding] 741091006960 domain linker motif; other site 741091006961 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 741091006962 YebF-like protein; Region: YebF; cl10126 741091006963 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 741091006964 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 741091006965 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 741091006966 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 741091006967 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 741091006968 MarR family; Region: MarR_2; pfam12802 741091006969 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 741091006970 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 741091006971 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 741091006972 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 741091006973 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 741091006974 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 741091006975 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 741091006976 conserved cys residue [active] 741091006977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091006978 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 741091006979 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741091006980 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741091006981 catalytic residue [active] 741091006982 Cupin domain; Region: Cupin_2; cl17218 741091006983 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 741091006984 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741091006985 active site 741091006986 metal binding site [ion binding]; metal-binding site 741091006987 hexamer interface [polypeptide binding]; other site 741091006988 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 741091006989 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 741091006990 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 741091006991 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 741091006992 conserved cys residue [active] 741091006993 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091006994 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 741091006995 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 741091006996 fumarate hydratase; Reviewed; Region: fumC; PRK00485 741091006997 Class II fumarases; Region: Fumarase_classII; cd01362 741091006998 active site 741091006999 tetramer interface [polypeptide binding]; other site 741091007000 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 741091007001 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 741091007002 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 741091007003 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 741091007004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 741091007005 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 741091007006 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 741091007007 Walker A/P-loop; other site 741091007008 ATP binding site [chemical binding]; other site 741091007009 Q-loop/lid; other site 741091007010 ABC transporter signature motif; other site 741091007011 Walker B; other site 741091007012 D-loop; other site 741091007013 H-loop/switch region; other site 741091007014 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 741091007015 Transcriptional regulators [Transcription]; Region: GntR; COG1802 741091007016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091007017 DNA-binding site [nucleotide binding]; DNA binding site 741091007018 FCD domain; Region: FCD; pfam07729 741091007019 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 741091007020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007021 dimer interface [polypeptide binding]; other site 741091007022 conserved gate region; other site 741091007023 putative PBP binding loops; other site 741091007024 ABC-ATPase subunit interface; other site 741091007025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007026 dimer interface [polypeptide binding]; other site 741091007027 conserved gate region; other site 741091007028 putative PBP binding loops; other site 741091007029 ABC-ATPase subunit interface; other site 741091007030 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 741091007031 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 741091007032 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 741091007033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091007034 Walker A/P-loop; other site 741091007035 ATP binding site [chemical binding]; other site 741091007036 Q-loop/lid; other site 741091007037 ABC transporter signature motif; other site 741091007038 Walker B; other site 741091007039 D-loop; other site 741091007040 H-loop/switch region; other site 741091007041 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 741091007042 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 741091007043 XdhC Rossmann domain; Region: XdhC_C; pfam13478 741091007044 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 741091007045 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 741091007046 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 741091007047 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 741091007048 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 741091007049 catalytic loop [active] 741091007050 iron binding site [ion binding]; other site 741091007051 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 741091007052 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 741091007053 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 741091007054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091007055 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 741091007056 guanine deaminase; Provisional; Region: PRK09228 741091007057 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 741091007058 active site 741091007059 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 741091007060 non-specific DNA interactions [nucleotide binding]; other site 741091007061 DNA binding site [nucleotide binding] 741091007062 sequence specific DNA binding site [nucleotide binding]; other site 741091007063 putative cAMP binding site [chemical binding]; other site 741091007064 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 741091007065 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741091007066 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 741091007067 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 741091007068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007069 dimer interface [polypeptide binding]; other site 741091007070 conserved gate region; other site 741091007071 putative PBP binding loops; other site 741091007072 ABC-ATPase subunit interface; other site 741091007073 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741091007074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007075 dimer interface [polypeptide binding]; other site 741091007076 conserved gate region; other site 741091007077 putative PBP binding loops; other site 741091007078 ABC-ATPase subunit interface; other site 741091007079 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741091007080 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 741091007081 substrate binding site [chemical binding]; other site 741091007082 ATP binding site [chemical binding]; other site 741091007083 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 741091007084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091007085 Walker A/P-loop; other site 741091007086 ATP binding site [chemical binding]; other site 741091007087 Q-loop/lid; other site 741091007088 ABC transporter signature motif; other site 741091007089 Walker B; other site 741091007090 D-loop; other site 741091007091 H-loop/switch region; other site 741091007092 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091007093 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091007094 active site 741091007095 catalytic tetrad [active] 741091007096 malonic semialdehyde reductase; Provisional; Region: PRK10538 741091007097 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 741091007098 putative NAD(P) binding site [chemical binding]; other site 741091007099 homodimer interface [polypeptide binding]; other site 741091007100 homotetramer interface [polypeptide binding]; other site 741091007101 active site 741091007102 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 741091007103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091007104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091007105 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091007106 dimerization interface [polypeptide binding]; other site 741091007107 hypothetical protein; Provisional; Region: PRK02237 741091007108 hypothetical protein; Provisional; Region: PRK13659 741091007109 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 741091007110 hypothetical protein; Provisional; Region: PRK10515 741091007111 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 741091007112 active site residue [active] 741091007113 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 741091007114 active site residue [active] 741091007115 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 741091007116 active site residue [active] 741091007117 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 741091007118 active site residue [active] 741091007119 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 741091007120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091007121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091007122 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 741091007123 dimerization interface [polypeptide binding]; other site 741091007124 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 741091007125 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 741091007126 dimer interface [polypeptide binding]; other site 741091007127 active site 741091007128 non-prolyl cis peptide bond; other site 741091007129 insertion regions; other site 741091007130 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 741091007131 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091007132 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 741091007133 membrane-bound complex binding site; other site 741091007134 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 741091007135 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 741091007136 conserved cys residue [active] 741091007137 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 741091007138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091007139 putative substrate translocation pore; other site 741091007140 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 741091007141 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 741091007142 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 741091007143 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 741091007144 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 741091007145 putative molybdopterin cofactor binding site [chemical binding]; other site 741091007146 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 741091007147 putative molybdopterin cofactor binding site; other site 741091007148 exoribonuclease II; Provisional; Region: PRK05054 741091007149 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 741091007150 RNB domain; Region: RNB; pfam00773 741091007151 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 741091007152 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 741091007153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091007154 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 741091007155 substrate binding site [chemical binding]; other site 741091007156 dimerization interface [polypeptide binding]; other site 741091007157 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 741091007158 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 741091007159 putative ligand binding site [chemical binding]; other site 741091007160 NAD binding site [chemical binding]; other site 741091007161 catalytic site [active] 741091007162 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 741091007163 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 741091007164 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 741091007165 active site 741091007166 catalytic site [active] 741091007167 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 741091007168 ApbE family; Region: ApbE; pfam02424 741091007169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 741091007170 Smr domain; Region: Smr; pfam01713 741091007171 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 741091007172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091007173 active site 741091007174 motif I; other site 741091007175 motif II; other site 741091007176 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 741091007177 Integral membrane protein TerC family; Region: TerC; cl10468 741091007178 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 741091007179 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 741091007180 ligand binding site [chemical binding]; other site 741091007181 flexible hinge region; other site 741091007182 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 741091007183 putative switch regulator; other site 741091007184 non-specific DNA interactions [nucleotide binding]; other site 741091007185 DNA binding site [nucleotide binding] 741091007186 sequence specific DNA binding site [nucleotide binding]; other site 741091007187 putative cAMP binding site [chemical binding]; other site 741091007188 universal stress protein UspE; Provisional; Region: PRK11175 741091007189 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 741091007190 Ligand Binding Site [chemical binding]; other site 741091007191 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 741091007192 Ligand Binding Site [chemical binding]; other site 741091007193 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 741091007194 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 741091007195 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 741091007196 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 741091007197 ligand binding site [chemical binding]; other site 741091007198 homodimer interface [polypeptide binding]; other site 741091007199 NAD(P) binding site [chemical binding]; other site 741091007200 trimer interface B [polypeptide binding]; other site 741091007201 trimer interface A [polypeptide binding]; other site 741091007202 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 741091007203 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741091007204 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741091007205 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741091007206 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 741091007207 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 741091007208 active site 741091007209 dimer interface [polypeptide binding]; other site 741091007210 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 741091007211 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 741091007212 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091007213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007214 putative PBP binding loops; other site 741091007215 dimer interface [polypeptide binding]; other site 741091007216 ABC-ATPase subunit interface; other site 741091007217 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091007218 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741091007219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007220 dimer interface [polypeptide binding]; other site 741091007221 conserved gate region; other site 741091007222 putative PBP binding loops; other site 741091007223 ABC-ATPase subunit interface; other site 741091007224 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 741091007225 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091007226 Walker A/P-loop; other site 741091007227 ATP binding site [chemical binding]; other site 741091007228 Q-loop/lid; other site 741091007229 ABC transporter signature motif; other site 741091007230 Walker B; other site 741091007231 D-loop; other site 741091007232 H-loop/switch region; other site 741091007233 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091007234 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 741091007235 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091007236 Walker A/P-loop; other site 741091007237 ATP binding site [chemical binding]; other site 741091007238 Q-loop/lid; other site 741091007239 ABC transporter signature motif; other site 741091007240 Walker B; other site 741091007241 D-loop; other site 741091007242 H-loop/switch region; other site 741091007243 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 741091007244 Beta-lactamase; Region: Beta-lactamase; pfam00144 741091007245 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 741091007246 4Fe-4S binding domain; Region: Fer4; pfam00037 741091007247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741091007248 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741091007249 Domain of unknown function (DUF336); Region: DUF336; pfam03928 741091007250 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 741091007251 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 741091007252 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 741091007253 Cytochrome c; Region: Cytochrom_C; pfam00034 741091007254 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 741091007255 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 741091007256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 741091007257 putative transporter; Provisional; Region: PRK11660 741091007258 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 741091007259 Sulfate transporter family; Region: Sulfate_transp; pfam00916 741091007260 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 741091007261 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 741091007262 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 741091007263 hypothetical protein; Provisional; Region: PRK10941 741091007264 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 741091007265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741091007266 binding surface 741091007267 TPR motif; other site 741091007268 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 741091007269 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 741091007270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091007271 peptide chain release factor 1; Validated; Region: prfA; PRK00591 741091007272 This domain is found in peptide chain release factors; Region: PCRF; smart00937 741091007273 RF-1 domain; Region: RF-1; pfam00472 741091007274 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 741091007275 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 741091007276 tRNA; other site 741091007277 putative tRNA binding site [nucleotide binding]; other site 741091007278 putative NADP binding site [chemical binding]; other site 741091007279 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 741091007280 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 741091007281 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 741091007282 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 741091007283 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 741091007284 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 741091007285 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 741091007286 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 741091007287 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741091007288 active site 741091007289 hypothetical protein; Provisional; Region: PRK10692 741091007290 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 741091007291 putative active site [active] 741091007292 catalytic residue [active] 741091007293 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 741091007294 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 741091007295 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 741091007296 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 741091007297 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 741091007298 HflC protein; Region: hflC; TIGR01932 741091007299 SPFH domain / Band 7 family; Region: Band_7; pfam01145 741091007300 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 741091007301 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 741091007302 Sulfate transporter family; Region: Sulfate_transp; pfam00916 741091007303 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 741091007304 GTP-binding protein YchF; Reviewed; Region: PRK09601 741091007305 YchF GTPase; Region: YchF; cd01900 741091007306 G1 box; other site 741091007307 GTP/Mg2+ binding site [chemical binding]; other site 741091007308 Switch I region; other site 741091007309 G2 box; other site 741091007310 Switch II region; other site 741091007311 G3 box; other site 741091007312 G4 box; other site 741091007313 G5 box; other site 741091007314 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 741091007315 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 741091007316 active site 741091007317 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 741091007318 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741091007319 N-terminal plug; other site 741091007320 ligand-binding site [chemical binding]; other site 741091007321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 741091007322 Transposase; Region: DEDD_Tnp_IS110; pfam01548 741091007323 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 741091007324 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 741091007325 HAMP domain; Region: HAMP; pfam00672 741091007326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091007327 dimer interface [polypeptide binding]; other site 741091007328 phosphorylation site [posttranslational modification] 741091007329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091007330 ATP binding site [chemical binding]; other site 741091007331 Mg2+ binding site [ion binding]; other site 741091007332 G-X-G motif; other site 741091007333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 741091007334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091007335 active site 741091007336 phosphorylation site [posttranslational modification] 741091007337 intermolecular recognition site; other site 741091007338 dimerization interface [polypeptide binding]; other site 741091007339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091007340 DNA binding site [nucleotide binding] 741091007341 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 741091007342 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 741091007343 Putative glucoamylase; Region: Glycoamylase; pfam10091 741091007344 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 741091007345 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 741091007346 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 741091007347 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 741091007348 FMN binding site [chemical binding]; other site 741091007349 dimer interface [polypeptide binding]; other site 741091007350 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091007351 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091007352 metal binding site [ion binding]; metal-binding site 741091007353 active site 741091007354 I-site; other site 741091007355 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091007356 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 741091007357 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 741091007358 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091007359 Coenzyme A binding pocket [chemical binding]; other site 741091007360 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 741091007361 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741091007362 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 741091007363 putative active site [active] 741091007364 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 741091007365 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091007366 substrate binding pocket [chemical binding]; other site 741091007367 membrane-bound complex binding site; other site 741091007368 hinge residues; other site 741091007369 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 741091007370 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 741091007371 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 741091007372 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 741091007373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007374 dimer interface [polypeptide binding]; other site 741091007375 conserved gate region; other site 741091007376 putative PBP binding loops; other site 741091007377 ABC-ATPase subunit interface; other site 741091007378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007379 dimer interface [polypeptide binding]; other site 741091007380 conserved gate region; other site 741091007381 putative PBP binding loops; other site 741091007382 ABC-ATPase subunit interface; other site 741091007383 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 741091007384 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 741091007385 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 741091007386 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091007387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091007388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091007389 dimerization interface [polypeptide binding]; other site 741091007390 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 741091007391 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741091007392 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 741091007393 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 741091007394 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 741091007395 putative active site [active] 741091007396 putative FMN binding site [chemical binding]; other site 741091007397 putative substrate binding site [chemical binding]; other site 741091007398 putative catalytic residue [active] 741091007399 FMN-binding domain; Region: FMN_bind; cl01081 741091007400 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 741091007401 L-aspartate oxidase; Provisional; Region: PRK06175 741091007402 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 741091007403 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 741091007404 transmembrane helices; other site 741091007405 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 741091007406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091007407 DNA-binding site [nucleotide binding]; DNA binding site 741091007408 FCD domain; Region: FCD; pfam07729 741091007409 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091007410 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 741091007411 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091007412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007413 dimer interface [polypeptide binding]; other site 741091007414 conserved gate region; other site 741091007415 putative PBP binding loops; other site 741091007416 ABC-ATPase subunit interface; other site 741091007417 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091007418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007419 dimer interface [polypeptide binding]; other site 741091007420 conserved gate region; other site 741091007421 putative PBP binding loops; other site 741091007422 ABC-ATPase subunit interface; other site 741091007423 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 741091007424 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 741091007425 metal binding site [ion binding]; metal-binding site 741091007426 D-cysteine desulfhydrase; Validated; Region: PRK03910 741091007427 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 741091007428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741091007429 catalytic residue [active] 741091007430 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 741091007431 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 741091007432 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 741091007433 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 741091007434 active site residue [active] 741091007435 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 741091007436 active site residue [active] 741091007437 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 741091007438 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091007439 Walker A/P-loop; other site 741091007440 ATP binding site [chemical binding]; other site 741091007441 Q-loop/lid; other site 741091007442 ABC transporter signature motif; other site 741091007443 Walker B; other site 741091007444 D-loop; other site 741091007445 H-loop/switch region; other site 741091007446 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091007447 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091007448 Walker A/P-loop; other site 741091007449 ATP binding site [chemical binding]; other site 741091007450 Q-loop/lid; other site 741091007451 ABC transporter signature motif; other site 741091007452 Walker B; other site 741091007453 D-loop; other site 741091007454 H-loop/switch region; other site 741091007455 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091007456 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 741091007457 glutathionine S-transferase; Provisional; Region: PRK10542 741091007458 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 741091007459 C-terminal domain interface [polypeptide binding]; other site 741091007460 GSH binding site (G-site) [chemical binding]; other site 741091007461 dimer interface [polypeptide binding]; other site 741091007462 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 741091007463 dimer interface [polypeptide binding]; other site 741091007464 N-terminal domain interface [polypeptide binding]; other site 741091007465 substrate binding pocket (H-site) [chemical binding]; other site 741091007466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091007467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091007468 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 741091007469 dimerization interface [polypeptide binding]; other site 741091007470 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 741091007471 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091007472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091007473 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 741091007474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091007475 NAD(P) binding site [chemical binding]; other site 741091007476 active site 741091007477 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 741091007478 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 741091007479 catalytic site [active] 741091007480 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 741091007481 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 741091007482 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 741091007483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091007484 dimerization interface [polypeptide binding]; other site 741091007485 putative DNA binding site [nucleotide binding]; other site 741091007486 putative Zn2+ binding site [ion binding]; other site 741091007487 AsnC family; Region: AsnC_trans_reg; pfam01037 741091007488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 741091007489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091007490 dimer interface [polypeptide binding]; other site 741091007491 phosphorylation site [posttranslational modification] 741091007492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091007493 ATP binding site [chemical binding]; other site 741091007494 Mg2+ binding site [ion binding]; other site 741091007495 G-X-G motif; other site 741091007496 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 741091007497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091007498 active site 741091007499 phosphorylation site [posttranslational modification] 741091007500 intermolecular recognition site; other site 741091007501 dimerization interface [polypeptide binding]; other site 741091007502 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091007503 DNA binding site [nucleotide binding] 741091007504 MltA-interacting protein MipA; Region: MipA; cl01504 741091007505 Predicted periplasmic protein [Function unknown]; Region: COG3904 741091007506 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 741091007507 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091007508 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 741091007509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091007510 putative substrate translocation pore; other site 741091007511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091007512 Coenzyme A binding pocket [chemical binding]; other site 741091007513 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 741091007514 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 741091007515 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 741091007516 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 741091007517 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 741091007518 Imelysin; Region: Peptidase_M75; pfam09375 741091007519 Iron permease FTR1 family; Region: FTR1; cl00475 741091007520 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 741091007521 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 741091007522 Ligand binding site; other site 741091007523 Putative Catalytic site; other site 741091007524 DXD motif; other site 741091007525 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 741091007526 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 741091007527 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 741091007528 ligand binding site; other site 741091007529 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 741091007530 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 741091007531 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 741091007532 active site 741091007533 intersubunit interface [polypeptide binding]; other site 741091007534 catalytic residue [active] 741091007535 phosphogluconate dehydratase; Validated; Region: PRK09054 741091007536 6-phosphogluconate dehydratase; Region: edd; TIGR01196 741091007537 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 741091007538 ATP-binding site [chemical binding]; other site 741091007539 Gluconate-6-phosphate binding site [chemical binding]; other site 741091007540 Shikimate kinase; Region: SKI; pfam01202 741091007541 hypothetical protein; Provisional; Region: PRK09929 741091007542 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 741091007543 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091007544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091007545 EamA-like transporter family; Region: EamA; pfam00892 741091007546 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 741091007547 EamA-like transporter family; Region: EamA; pfam00892 741091007548 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 741091007549 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 741091007550 putative NAD(P) binding site [chemical binding]; other site 741091007551 putative substrate binding site [chemical binding]; other site 741091007552 catalytic Zn binding site [ion binding]; other site 741091007553 structural Zn binding site [ion binding]; other site 741091007554 dimer interface [polypeptide binding]; other site 741091007555 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 741091007556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091007557 DNA-binding site [nucleotide binding]; DNA binding site 741091007558 UTRA domain; Region: UTRA; pfam07702 741091007559 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 741091007560 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 741091007561 substrate binding site [chemical binding]; other site 741091007562 oxyanion hole (OAH) forming residues; other site 741091007563 trimer interface [polypeptide binding]; other site 741091007564 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 741091007565 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 741091007566 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 741091007567 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 741091007568 CoA-transferase family III; Region: CoA_transf_3; pfam02515 741091007569 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 741091007570 active sites [active] 741091007571 tetramer interface [polypeptide binding]; other site 741091007572 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 741091007573 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 741091007574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007575 dimer interface [polypeptide binding]; other site 741091007576 conserved gate region; other site 741091007577 ABC-ATPase subunit interface; other site 741091007578 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 741091007579 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 741091007580 Walker A/P-loop; other site 741091007581 ATP binding site [chemical binding]; other site 741091007582 Q-loop/lid; other site 741091007583 ABC transporter signature motif; other site 741091007584 Walker B; other site 741091007585 D-loop; other site 741091007586 H-loop/switch region; other site 741091007587 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 741091007588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091007589 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 741091007590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091007591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091007592 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 741091007593 putative effector binding pocket; other site 741091007594 dimerization interface [polypeptide binding]; other site 741091007595 Pirin-related protein [General function prediction only]; Region: COG1741 741091007596 Pirin; Region: Pirin; pfam02678 741091007597 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 741091007598 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 741091007599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091007600 Coenzyme A binding pocket [chemical binding]; other site 741091007601 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 741091007602 Coenzyme A binding pocket [chemical binding]; other site 741091007603 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 741091007604 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 741091007605 active site 741091007606 non-prolyl cis peptide bond; other site 741091007607 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741091007608 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091007609 Walker A/P-loop; other site 741091007610 ATP binding site [chemical binding]; other site 741091007611 Q-loop/lid; other site 741091007612 ABC transporter signature motif; other site 741091007613 Walker B; other site 741091007614 D-loop; other site 741091007615 H-loop/switch region; other site 741091007616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007617 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741091007618 dimer interface [polypeptide binding]; other site 741091007619 conserved gate region; other site 741091007620 putative PBP binding loops; other site 741091007621 ABC-ATPase subunit interface; other site 741091007622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091007623 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 741091007624 substrate binding pocket [chemical binding]; other site 741091007625 membrane-bound complex binding site; other site 741091007626 hinge residues; other site 741091007627 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 741091007628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007629 dimer interface [polypeptide binding]; other site 741091007630 conserved gate region; other site 741091007631 putative PBP binding loops; other site 741091007632 ABC-ATPase subunit interface; other site 741091007633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007634 dimer interface [polypeptide binding]; other site 741091007635 conserved gate region; other site 741091007636 putative PBP binding loops; other site 741091007637 ABC-ATPase subunit interface; other site 741091007638 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741091007639 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091007640 Walker A/P-loop; other site 741091007641 ATP binding site [chemical binding]; other site 741091007642 Q-loop/lid; other site 741091007643 ABC transporter signature motif; other site 741091007644 Walker B; other site 741091007645 D-loop; other site 741091007646 H-loop/switch region; other site 741091007647 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 741091007648 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091007649 substrate binding pocket [chemical binding]; other site 741091007650 membrane-bound complex binding site; other site 741091007651 hinge residues; other site 741091007652 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 741091007653 active site 741091007654 SAM binding site [chemical binding]; other site 741091007655 homodimer interface [polypeptide binding]; other site 741091007656 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 741091007657 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 741091007658 [4Fe-4S] binding site [ion binding]; other site 741091007659 molybdopterin cofactor binding site; other site 741091007660 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 741091007661 molybdopterin cofactor binding site; other site 741091007662 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 741091007663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 741091007664 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 741091007665 nitrite reductase subunit NirD; Provisional; Region: PRK14989 741091007666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741091007667 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 741091007668 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 741091007669 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 741091007670 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 741091007671 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 741091007672 Walker A/P-loop; other site 741091007673 ATP binding site [chemical binding]; other site 741091007674 Q-loop/lid; other site 741091007675 ABC transporter signature motif; other site 741091007676 Walker B; other site 741091007677 D-loop; other site 741091007678 H-loop/switch region; other site 741091007679 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 741091007680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007681 dimer interface [polypeptide binding]; other site 741091007682 conserved gate region; other site 741091007683 putative PBP binding loops; other site 741091007684 ABC-ATPase subunit interface; other site 741091007685 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 741091007686 NMT1-like family; Region: NMT1_2; pfam13379 741091007687 Nitrate and nitrite sensing; Region: NIT; pfam08376 741091007688 ANTAR domain; Region: ANTAR; pfam03861 741091007689 Flagellin N-methylase; Region: FliB; pfam03692 741091007690 Predicted transcriptional regulator [Transcription]; Region: COG2378 741091007691 HTH domain; Region: HTH_11; cl17392 741091007692 WYL domain; Region: WYL; pfam13280 741091007693 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 741091007694 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 741091007695 beta-galactosidase; Region: BGL; TIGR03356 741091007696 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 741091007697 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741091007698 active site turn [active] 741091007699 phosphorylation site [posttranslational modification] 741091007700 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 741091007701 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741091007702 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091007703 DNA binding site [nucleotide binding] 741091007704 domain linker motif; other site 741091007705 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 741091007706 dimerization interface (closed form) [polypeptide binding]; other site 741091007707 ligand binding site [chemical binding]; other site 741091007708 PAS domain S-box; Region: sensory_box; TIGR00229 741091007709 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091007710 putative active site [active] 741091007711 heme pocket [chemical binding]; other site 741091007712 PAS domain; Region: PAS_9; pfam13426 741091007713 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091007714 metal binding site [ion binding]; metal-binding site 741091007715 active site 741091007716 I-site; other site 741091007717 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091007718 Transcriptional regulators [Transcription]; Region: FadR; COG2186 741091007719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091007720 DNA-binding site [nucleotide binding]; DNA binding site 741091007721 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 741091007722 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 741091007723 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091007724 Walker A/P-loop; other site 741091007725 ATP binding site [chemical binding]; other site 741091007726 Q-loop/lid; other site 741091007727 ABC transporter signature motif; other site 741091007728 Walker B; other site 741091007729 D-loop; other site 741091007730 H-loop/switch region; other site 741091007731 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 741091007732 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 741091007733 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091007734 Walker A/P-loop; other site 741091007735 ATP binding site [chemical binding]; other site 741091007736 Q-loop/lid; other site 741091007737 ABC transporter signature motif; other site 741091007738 Walker B; other site 741091007739 D-loop; other site 741091007740 H-loop/switch region; other site 741091007741 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 741091007742 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091007743 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 741091007744 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091007745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007746 dimer interface [polypeptide binding]; other site 741091007747 conserved gate region; other site 741091007748 ABC-ATPase subunit interface; other site 741091007749 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091007750 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741091007751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007752 dimer interface [polypeptide binding]; other site 741091007753 conserved gate region; other site 741091007754 putative PBP binding loops; other site 741091007755 ABC-ATPase subunit interface; other site 741091007756 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 741091007757 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 741091007758 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 741091007759 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 741091007760 inhibitor site; inhibition site 741091007761 active site 741091007762 dimer interface [polypeptide binding]; other site 741091007763 catalytic residue [active] 741091007764 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 741091007765 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 741091007766 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 741091007767 metabolite-proton symporter; Region: 2A0106; TIGR00883 741091007768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091007769 putative substrate translocation pore; other site 741091007770 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 741091007771 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741091007772 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 741091007773 putative active site [active] 741091007774 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 741091007775 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 741091007776 active site 741091007777 NAD binding site [chemical binding]; other site 741091007778 metal binding site [ion binding]; metal-binding site 741091007779 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 741091007780 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 741091007781 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 741091007782 active site 741091007783 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 741091007784 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 741091007785 metal binding site [ion binding]; metal-binding site 741091007786 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 741091007787 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091007788 Walker A/P-loop; other site 741091007789 ATP binding site [chemical binding]; other site 741091007790 Q-loop/lid; other site 741091007791 ABC transporter signature motif; other site 741091007792 Walker B; other site 741091007793 D-loop; other site 741091007794 H-loop/switch region; other site 741091007795 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091007796 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091007797 Walker A/P-loop; other site 741091007798 ATP binding site [chemical binding]; other site 741091007799 Q-loop/lid; other site 741091007800 ABC transporter signature motif; other site 741091007801 Walker B; other site 741091007802 D-loop; other site 741091007803 H-loop/switch region; other site 741091007804 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091007805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007806 dimer interface [polypeptide binding]; other site 741091007807 conserved gate region; other site 741091007808 putative PBP binding loops; other site 741091007809 ABC-ATPase subunit interface; other site 741091007810 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091007811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007812 dimer interface [polypeptide binding]; other site 741091007813 conserved gate region; other site 741091007814 putative PBP binding loops; other site 741091007815 ABC-ATPase subunit interface; other site 741091007816 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091007817 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 741091007818 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 741091007819 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 741091007820 metal binding site [ion binding]; metal-binding site 741091007821 dimer interface [polypeptide binding]; other site 741091007822 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 741091007823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091007824 DNA-binding site [nucleotide binding]; DNA binding site 741091007825 UTRA domain; Region: UTRA; pfam07702 741091007826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091007827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091007828 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091007829 dimerization interface [polypeptide binding]; other site 741091007830 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 741091007831 SxDxEG motif; other site 741091007832 active site 741091007833 metal binding site [ion binding]; metal-binding site 741091007834 homopentamer interface [polypeptide binding]; other site 741091007835 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 741091007836 homodimer interface [polypeptide binding]; other site 741091007837 homotetramer interface [polypeptide binding]; other site 741091007838 active site pocket [active] 741091007839 cleavage site 741091007840 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 741091007841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007842 dimer interface [polypeptide binding]; other site 741091007843 conserved gate region; other site 741091007844 putative PBP binding loops; other site 741091007845 ABC-ATPase subunit interface; other site 741091007846 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 741091007847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007848 dimer interface [polypeptide binding]; other site 741091007849 conserved gate region; other site 741091007850 putative PBP binding loops; other site 741091007851 ABC-ATPase subunit interface; other site 741091007852 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 741091007853 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 741091007854 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 741091007855 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091007856 Walker A/P-loop; other site 741091007857 ATP binding site [chemical binding]; other site 741091007858 Q-loop/lid; other site 741091007859 ABC transporter signature motif; other site 741091007860 Walker B; other site 741091007861 D-loop; other site 741091007862 H-loop/switch region; other site 741091007863 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 741091007864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091007865 Walker A/P-loop; other site 741091007866 ATP binding site [chemical binding]; other site 741091007867 Q-loop/lid; other site 741091007868 ABC transporter signature motif; other site 741091007869 Walker B; other site 741091007870 D-loop; other site 741091007871 H-loop/switch region; other site 741091007872 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 741091007873 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 741091007874 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 741091007875 active site 741091007876 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 741091007877 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741091007878 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 741091007879 trimer interface [polypeptide binding]; other site 741091007880 eyelet of channel; other site 741091007881 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 741091007882 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741091007883 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 741091007884 Walker A/P-loop; other site 741091007885 ATP binding site [chemical binding]; other site 741091007886 Q-loop/lid; other site 741091007887 ABC transporter signature motif; other site 741091007888 Walker B; other site 741091007889 D-loop; other site 741091007890 H-loop/switch region; other site 741091007891 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 741091007892 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 741091007893 homodimer interface [polypeptide binding]; other site 741091007894 substrate-cofactor binding pocket; other site 741091007895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091007896 catalytic residue [active] 741091007897 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 741091007898 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 741091007899 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 741091007900 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 741091007901 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 741091007902 [4Fe-4S] binding site [ion binding]; other site 741091007903 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 741091007904 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 741091007905 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 741091007906 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 741091007907 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 741091007908 molybdopterin cofactor binding site; other site 741091007909 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 741091007910 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 741091007911 Cl binding site [ion binding]; other site 741091007912 oligomer interface [polypeptide binding]; other site 741091007913 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 741091007914 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 741091007915 Cl- selectivity filter; other site 741091007916 Cl- binding residues [ion binding]; other site 741091007917 pore gating glutamate residue; other site 741091007918 dimer interface [polypeptide binding]; other site 741091007919 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 741091007920 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 741091007921 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 741091007922 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091007923 non-specific DNA binding site [nucleotide binding]; other site 741091007924 salt bridge; other site 741091007925 sequence-specific DNA binding site [nucleotide binding]; other site 741091007926 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091007927 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 741091007928 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 741091007929 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091007930 Walker A/P-loop; other site 741091007931 ATP binding site [chemical binding]; other site 741091007932 Q-loop/lid; other site 741091007933 ABC transporter signature motif; other site 741091007934 Walker B; other site 741091007935 D-loop; other site 741091007936 H-loop/switch region; other site 741091007937 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 741091007938 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091007939 Walker A/P-loop; other site 741091007940 ATP binding site [chemical binding]; other site 741091007941 Q-loop/lid; other site 741091007942 ABC transporter signature motif; other site 741091007943 Walker B; other site 741091007944 D-loop; other site 741091007945 H-loop/switch region; other site 741091007946 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 741091007947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007948 dimer interface [polypeptide binding]; other site 741091007949 conserved gate region; other site 741091007950 putative PBP binding loops; other site 741091007951 ABC-ATPase subunit interface; other site 741091007952 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091007953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091007954 putative PBP binding loops; other site 741091007955 dimer interface [polypeptide binding]; other site 741091007956 ABC-ATPase subunit interface; other site 741091007957 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091007958 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 741091007959 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 741091007960 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 741091007961 putative active site pocket [active] 741091007962 dimerization interface [polypeptide binding]; other site 741091007963 putative catalytic residue [active] 741091007964 cation transport regulator; Reviewed; Region: chaB; PRK09582 741091007965 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 741091007966 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 741091007967 hypothetical protein; Provisional; Region: PRK10536 741091007968 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 741091007969 AMIN domain; Region: AMIN; pfam11741 741091007970 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 741091007971 active site 741091007972 metal binding site [ion binding]; metal-binding site 741091007973 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 741091007974 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 741091007975 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 741091007976 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 741091007977 Imelysin; Region: Peptidase_M75; pfam09375 741091007978 FTR1 family protein; Region: TIGR00145 741091007979 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 741091007980 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 741091007981 Na binding site [ion binding]; other site 741091007982 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 741091007983 Predicted transcriptional regulator [Transcription]; Region: COG3905 741091007984 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 741091007985 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 741091007986 Glutamate binding site [chemical binding]; other site 741091007987 NAD binding site [chemical binding]; other site 741091007988 catalytic residues [active] 741091007989 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 741091007990 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091007991 Walker A/P-loop; other site 741091007992 ATP binding site [chemical binding]; other site 741091007993 Q-loop/lid; other site 741091007994 ABC transporter signature motif; other site 741091007995 Walker B; other site 741091007996 D-loop; other site 741091007997 H-loop/switch region; other site 741091007998 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091007999 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741091008000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008001 dimer interface [polypeptide binding]; other site 741091008002 conserved gate region; other site 741091008003 putative PBP binding loops; other site 741091008004 ABC-ATPase subunit interface; other site 741091008005 cystine transporter subunit; Provisional; Region: PRK11260 741091008006 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091008007 substrate binding pocket [chemical binding]; other site 741091008008 membrane-bound complex binding site; other site 741091008009 hinge residues; other site 741091008010 D-cysteine desulfhydrase; Validated; Region: PRK03910 741091008011 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 741091008012 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741091008013 catalytic residue [active] 741091008014 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 741091008015 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 741091008016 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 741091008017 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 741091008018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741091008019 DNA binding residues [nucleotide binding] 741091008020 flagellin; Validated; Region: PRK06819 741091008021 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 741091008022 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 741091008023 flagellar capping protein; Reviewed; Region: fliD; PRK08032 741091008024 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 741091008025 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 741091008026 flagellar protein FliS; Validated; Region: fliS; PRK05685 741091008027 Flagellar protein FliT; Region: FliT; cl05125 741091008028 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091008029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091008030 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 741091008031 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 741091008032 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 741091008033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091008034 Coenzyme A binding pocket [chemical binding]; other site 741091008035 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 741091008036 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 741091008037 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 741091008038 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 741091008039 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 741091008040 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 741091008041 FliG C-terminal domain; Region: FliG_C; pfam01706 741091008042 flagellar assembly protein H; Validated; Region: fliH; PRK05687 741091008043 Flagellar assembly protein FliH; Region: FliH; pfam02108 741091008044 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 741091008045 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 741091008046 Walker A motif/ATP binding site; other site 741091008047 Walker B motif; other site 741091008048 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 741091008049 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 741091008050 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 741091008051 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 741091008052 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 741091008053 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 741091008054 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 741091008055 flagellar motor switch protein; Validated; Region: fliN; PRK05698 741091008056 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 741091008057 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 741091008058 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 741091008059 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 741091008060 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 741091008061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091008062 S-adenosylmethionine binding site [chemical binding]; other site 741091008063 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 741091008064 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 741091008065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008066 dimer interface [polypeptide binding]; other site 741091008067 conserved gate region; other site 741091008068 putative PBP binding loops; other site 741091008069 ABC-ATPase subunit interface; other site 741091008070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008071 dimer interface [polypeptide binding]; other site 741091008072 conserved gate region; other site 741091008073 putative PBP binding loops; other site 741091008074 ABC-ATPase subunit interface; other site 741091008075 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 741091008076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091008077 Walker A/P-loop; other site 741091008078 ATP binding site [chemical binding]; other site 741091008079 Q-loop/lid; other site 741091008080 ABC transporter signature motif; other site 741091008081 Walker B; other site 741091008082 D-loop; other site 741091008083 H-loop/switch region; other site 741091008084 TOBE domain; Region: TOBE_2; pfam08402 741091008085 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 741091008086 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 741091008087 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 741091008088 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 741091008089 RimK-like ATP-grasp domain; Region: RimK; pfam08443 741091008090 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 741091008091 dimer interface [polypeptide binding]; other site 741091008092 FMN binding site [chemical binding]; other site 741091008093 NADPH bind site [chemical binding]; other site 741091008094 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 741091008095 GSH binding site [chemical binding]; other site 741091008096 catalytic residues [active] 741091008097 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 741091008098 putative transporter; Provisional; Region: PRK04972 741091008099 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 741091008100 TrkA-C domain; Region: TrkA_C; pfam02080 741091008101 TrkA-C domain; Region: TrkA_C; pfam02080 741091008102 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 741091008103 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 741091008104 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 741091008105 Baseplate J-like protein; Region: Baseplate_J; pfam04865 741091008106 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 741091008107 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 741091008108 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 741091008109 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 741091008110 Phage holin family 2; Region: Phage_holin_2; pfam04550 741091008111 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 741091008112 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 741091008113 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 741091008114 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 741091008115 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 741091008116 terminase endonuclease subunit; Provisional; Region: M; PHA02537 741091008117 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 741091008118 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 741091008119 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 741091008120 terminase ATPase subunit; Provisional; Region: P; PHA02535 741091008121 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 741091008122 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 741091008123 Phage-related protein [Function unknown]; Region: COG4695; cl01923 741091008124 Phage portal protein; Region: Phage_portal; pfam04860 741091008125 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 741091008126 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 741091008127 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 741091008128 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 741091008129 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 741091008130 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 741091008131 integrase; Provisional; Region: int; PHA02601 741091008132 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741091008133 active site 741091008134 DNA binding site [nucleotide binding] 741091008135 Int/Topo IB signature motif; other site 741091008136 Protein of unknown function (DUF796); Region: DUF796; cl01226 741091008137 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 741091008138 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 741091008139 active site 741091008140 metal binding site [ion binding]; metal-binding site 741091008141 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741091008142 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 741091008143 trimer interface [polypeptide binding]; other site 741091008144 eyelet of channel; other site 741091008145 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 741091008146 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 741091008147 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 741091008148 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 741091008149 active site 741091008150 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 741091008151 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 741091008152 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 741091008153 GlpM protein; Region: GlpM; pfam06942 741091008154 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 741091008155 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 741091008156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091008157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091008158 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091008159 dimerization interface [polypeptide binding]; other site 741091008160 hypothetical protein; Provisional; Region: PRK07079 741091008161 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 741091008162 metal binding site [ion binding]; metal-binding site 741091008163 putative dimer interface [polypeptide binding]; other site 741091008164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091008165 metabolite-proton symporter; Region: 2A0106; TIGR00883 741091008166 putative substrate translocation pore; other site 741091008167 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 741091008168 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 741091008169 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 741091008170 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 741091008171 putative ligand binding site [chemical binding]; other site 741091008172 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 741091008173 putative transporter; Provisional; Region: PRK11462 741091008174 putative alpha-glucosidase; Provisional; Region: PRK10658 741091008175 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 741091008176 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 741091008177 active site 741091008178 homotrimer interface [polypeptide binding]; other site 741091008179 catalytic site [active] 741091008180 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 741091008181 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 741091008182 putative dimerization interface [polypeptide binding]; other site 741091008183 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741091008184 putative ligand binding site [chemical binding]; other site 741091008185 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091008186 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091008187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091008188 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091008189 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091008190 TM-ABC transporter signature motif; other site 741091008191 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 741091008192 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741091008193 Walker A/P-loop; other site 741091008194 ATP binding site [chemical binding]; other site 741091008195 Q-loop/lid; other site 741091008196 ABC transporter signature motif; other site 741091008197 Walker B; other site 741091008198 D-loop; other site 741091008199 H-loop/switch region; other site 741091008200 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741091008201 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 741091008202 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 741091008203 putative ligand binding site [chemical binding]; other site 741091008204 xylose isomerase; Provisional; Region: PRK05474 741091008205 xylose isomerase; Region: xylose_isom_A; TIGR02630 741091008206 xylulokinase; Provisional; Region: PRK15027 741091008207 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 741091008208 N- and C-terminal domain interface [polypeptide binding]; other site 741091008209 active site 741091008210 MgATP binding site [chemical binding]; other site 741091008211 catalytic site [active] 741091008212 metal binding site [ion binding]; metal-binding site 741091008213 xylulose binding site [chemical binding]; other site 741091008214 homodimer interface [polypeptide binding]; other site 741091008215 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 741091008216 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 741091008217 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 741091008218 putative active site; other site 741091008219 catalytic residue [active] 741091008220 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 741091008221 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 741091008222 ligand binding site [chemical binding]; other site 741091008223 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091008224 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091008225 TM-ABC transporter signature motif; other site 741091008226 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091008227 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091008228 TM-ABC transporter signature motif; other site 741091008229 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 741091008230 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741091008231 Walker A/P-loop; other site 741091008232 ATP binding site [chemical binding]; other site 741091008233 Q-loop/lid; other site 741091008234 ABC transporter signature motif; other site 741091008235 Walker B; other site 741091008236 D-loop; other site 741091008237 H-loop/switch region; other site 741091008238 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741091008239 transcriptional regulator LsrR; Provisional; Region: PRK15418 741091008240 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 741091008241 non-specific DNA interactions [nucleotide binding]; other site 741091008242 DNA binding site [nucleotide binding] 741091008243 sequence specific DNA binding site [nucleotide binding]; other site 741091008244 putative cAMP binding site [chemical binding]; other site 741091008245 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 741091008246 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 741091008247 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 741091008248 putative N- and C-terminal domain interface [polypeptide binding]; other site 741091008249 putative active site [active] 741091008250 putative MgATP binding site [chemical binding]; other site 741091008251 catalytic site [active] 741091008252 metal binding site [ion binding]; metal-binding site 741091008253 putative carbohydrate binding site [chemical binding]; other site 741091008254 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 741091008255 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 741091008256 active site 741091008257 intersubunit interactions; other site 741091008258 catalytic residue [active] 741091008259 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 741091008260 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091008261 FeS/SAM binding site; other site 741091008262 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 741091008263 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 741091008264 dimer interface [polypeptide binding]; other site 741091008265 active site 741091008266 glycine loop; other site 741091008267 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 741091008268 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 741091008269 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741091008270 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 741091008271 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 741091008272 intersubunit interface [polypeptide binding]; other site 741091008273 active site 741091008274 Zn2+ binding site [ion binding]; other site 741091008275 lipoprotein; Provisional; Region: PRK10540 741091008276 translation initiation factor Sui1; Validated; Region: PRK06824 741091008277 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 741091008278 putative rRNA binding site [nucleotide binding]; other site 741091008279 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 741091008280 active site 741091008281 dimer interface [polypeptide binding]; other site 741091008282 tetratricopeptide repeat protein; Provisional; Region: PRK11788 741091008283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741091008284 TPR motif; other site 741091008285 binding surface 741091008286 Predicted membrane protein [Function unknown]; Region: COG3771 741091008287 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 741091008288 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 741091008289 active site 741091008290 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 741091008291 dimerization interface [polypeptide binding]; other site 741091008292 active site 741091008293 aconitate hydratase; Validated; Region: PRK09277 741091008294 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 741091008295 substrate binding site [chemical binding]; other site 741091008296 ligand binding site [chemical binding]; other site 741091008297 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 741091008298 substrate binding site [chemical binding]; other site 741091008299 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 741091008300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091008301 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 741091008302 substrate binding site [chemical binding]; other site 741091008303 putative dimerization interface [polypeptide binding]; other site 741091008304 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 741091008305 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 741091008306 active site 741091008307 interdomain interaction site; other site 741091008308 putative metal-binding site [ion binding]; other site 741091008309 nucleotide binding site [chemical binding]; other site 741091008310 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 741091008311 domain I; other site 741091008312 DNA binding groove [nucleotide binding] 741091008313 phosphate binding site [ion binding]; other site 741091008314 domain II; other site 741091008315 domain III; other site 741091008316 nucleotide binding site [chemical binding]; other site 741091008317 catalytic site [active] 741091008318 domain IV; other site 741091008319 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 741091008320 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 741091008321 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 741091008322 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 741091008323 hypothetical protein; Provisional; Region: PRK11037 741091008324 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 741091008325 putative inner membrane peptidase; Provisional; Region: PRK11778 741091008326 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 741091008327 tandem repeat interface [polypeptide binding]; other site 741091008328 oligomer interface [polypeptide binding]; other site 741091008329 active site residues [active] 741091008330 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 741091008331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091008332 NAD(P) binding site [chemical binding]; other site 741091008333 active site 741091008334 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 741091008335 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 741091008336 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 741091008337 homodimer interface [polypeptide binding]; other site 741091008338 Walker A motif; other site 741091008339 ATP binding site [chemical binding]; other site 741091008340 hydroxycobalamin binding site [chemical binding]; other site 741091008341 Walker B motif; other site 741091008342 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 741091008343 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 741091008344 putative dimer interface [polypeptide binding]; other site 741091008345 active site pocket [active] 741091008346 putative cataytic base [active] 741091008347 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 741091008348 catalytic core [active] 741091008349 cobalamin synthase; Reviewed; Region: cobS; PRK00235 741091008350 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 741091008351 homotrimer interface [polypeptide binding]; other site 741091008352 Walker A motif; other site 741091008353 GTP binding site [chemical binding]; other site 741091008354 Walker B motif; other site 741091008355 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 741091008356 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741091008357 RNA binding surface [nucleotide binding]; other site 741091008358 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 741091008359 probable active site [active] 741091008360 hypothetical protein; Provisional; Region: PRK11630 741091008361 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 741091008362 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 741091008363 active site 741091008364 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 741091008365 anthranilate synthase component I; Provisional; Region: PRK13564 741091008366 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 741091008367 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 741091008368 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 741091008369 Glutamine amidotransferase class-I; Region: GATase; pfam00117 741091008370 glutamine binding [chemical binding]; other site 741091008371 catalytic triad [active] 741091008372 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 741091008373 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 741091008374 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 741091008375 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 741091008376 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 741091008377 active site 741091008378 ribulose/triose binding site [chemical binding]; other site 741091008379 phosphate binding site [ion binding]; other site 741091008380 substrate (anthranilate) binding pocket [chemical binding]; other site 741091008381 product (indole) binding pocket [chemical binding]; other site 741091008382 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 741091008383 active site 741091008384 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 741091008385 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 741091008386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091008387 catalytic residue [active] 741091008388 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 741091008389 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 741091008390 substrate binding site [chemical binding]; other site 741091008391 active site 741091008392 catalytic residues [active] 741091008393 heterodimer interface [polypeptide binding]; other site 741091008394 BON domain; Region: BON; pfam04972 741091008395 outer membrane protein W; Provisional; Region: PRK10959 741091008396 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 741091008397 hypothetical protein; Provisional; Region: PRK02868 741091008398 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 741091008399 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741091008400 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 741091008401 intracellular septation protein A; Reviewed; Region: PRK00259 741091008402 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 741091008403 transport protein TonB; Provisional; Region: PRK10819 741091008404 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 741091008405 YciI-like protein; Reviewed; Region: PRK11370 741091008406 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 741091008407 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 741091008408 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 741091008409 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 741091008410 putative active site [active] 741091008411 catalytic site [active] 741091008412 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 741091008413 putative active site [active] 741091008414 catalytic site [active] 741091008415 dsDNA-mimic protein; Reviewed; Region: PRK05094 741091008416 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 741091008417 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091008418 Walker A/P-loop; other site 741091008419 ATP binding site [chemical binding]; other site 741091008420 Q-loop/lid; other site 741091008421 ABC transporter signature motif; other site 741091008422 Walker B; other site 741091008423 D-loop; other site 741091008424 H-loop/switch region; other site 741091008425 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 741091008426 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 741091008427 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091008428 Walker A/P-loop; other site 741091008429 ATP binding site [chemical binding]; other site 741091008430 Q-loop/lid; other site 741091008431 ABC transporter signature motif; other site 741091008432 Walker B; other site 741091008433 D-loop; other site 741091008434 H-loop/switch region; other site 741091008435 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091008436 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 741091008437 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741091008438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008439 dimer interface [polypeptide binding]; other site 741091008440 conserved gate region; other site 741091008441 putative PBP binding loops; other site 741091008442 ABC-ATPase subunit interface; other site 741091008443 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 741091008444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008445 dimer interface [polypeptide binding]; other site 741091008446 conserved gate region; other site 741091008447 putative PBP binding loops; other site 741091008448 ABC-ATPase subunit interface; other site 741091008449 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 741091008450 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 741091008451 peptide binding site [polypeptide binding]; other site 741091008452 hypothetical protein; Provisional; Region: PRK11111 741091008453 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 741091008454 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 741091008455 putative catalytic cysteine [active] 741091008456 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 741091008457 putative active site [active] 741091008458 metal binding site [ion binding]; metal-binding site 741091008459 thymidine kinase; Provisional; Region: PRK04296 741091008460 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 741091008461 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 741091008462 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 741091008463 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 741091008464 putative NAD(P) binding site [chemical binding]; other site 741091008465 active site 741091008466 putative substrate binding site [chemical binding]; other site 741091008467 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 741091008468 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 741091008469 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 741091008470 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 741091008471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091008472 active site 741091008473 response regulator of RpoS; Provisional; Region: PRK10693 741091008474 phosphorylation site [posttranslational modification] 741091008475 intermolecular recognition site; other site 741091008476 dimerization interface [polypeptide binding]; other site 741091008477 hypothetical protein; Provisional; Region: PRK10279 741091008478 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 741091008479 active site 741091008480 nucleophile elbow; other site 741091008481 hypothetical protein; Provisional; Region: PRK01617 741091008482 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 741091008483 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 741091008484 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 741091008485 putative active site [active] 741091008486 putative substrate binding site [chemical binding]; other site 741091008487 putative cosubstrate binding site; other site 741091008488 catalytic site [active] 741091008489 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 741091008490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091008491 Walker A/P-loop; other site 741091008492 ATP binding site [chemical binding]; other site 741091008493 Q-loop/lid; other site 741091008494 ABC transporter signature motif; other site 741091008495 Walker B; other site 741091008496 D-loop; other site 741091008497 H-loop/switch region; other site 741091008498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091008499 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091008500 Walker A/P-loop; other site 741091008501 ATP binding site [chemical binding]; other site 741091008502 Q-loop/lid; other site 741091008503 ABC transporter signature motif; other site 741091008504 Walker B; other site 741091008505 D-loop; other site 741091008506 H-loop/switch region; other site 741091008507 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 741091008508 Uncharacterized conserved protein [Function unknown]; Region: COG5476 741091008509 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 741091008510 MlrC C-terminus; Region: MlrC_C; pfam07171 741091008511 MarR family; Region: MarR_2; pfam12802 741091008512 Transcriptional regulators [Transcription]; Region: MarR; COG1846 741091008513 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 741091008514 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741091008515 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 741091008516 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 741091008517 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091008518 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091008519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008520 dimer interface [polypeptide binding]; other site 741091008521 conserved gate region; other site 741091008522 putative PBP binding loops; other site 741091008523 ABC-ATPase subunit interface; other site 741091008524 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091008525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008526 dimer interface [polypeptide binding]; other site 741091008527 conserved gate region; other site 741091008528 putative PBP binding loops; other site 741091008529 ABC-ATPase subunit interface; other site 741091008530 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 741091008531 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741091008532 nucleotide binding site [chemical binding]; other site 741091008533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 741091008534 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 741091008535 diaminopimelate epimerase; Provisional; Region: PRK13577 741091008536 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 741091008537 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 741091008538 benzoate transport; Region: 2A0115; TIGR00895 741091008539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091008540 putative substrate translocation pore; other site 741091008541 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 741091008542 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 741091008543 putative active site [active] 741091008544 Fe(II) binding site [ion binding]; other site 741091008545 putative dimer interface [polypeptide binding]; other site 741091008546 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 741091008547 putative dimer interface [polypeptide binding]; other site 741091008548 putative N- and C-terminal domain interface [polypeptide binding]; other site 741091008549 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 741091008550 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 741091008551 active site 741091008552 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 741091008553 Dehydroquinase class II; Region: DHquinase_II; pfam01220 741091008554 trimer interface [polypeptide binding]; other site 741091008555 active site 741091008556 dimer interface [polypeptide binding]; other site 741091008557 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 741091008558 O-Antigen ligase; Region: Wzy_C; pfam04932 741091008559 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 741091008560 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 741091008561 putative ADP-binding pocket [chemical binding]; other site 741091008562 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091008563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091008564 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 741091008565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091008566 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 741091008567 putative dimerization interface [polypeptide binding]; other site 741091008568 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 741091008569 hypothetical protein; Provisional; Region: PRK09262 741091008570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 741091008571 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 741091008572 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 741091008573 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 741091008574 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091008575 Walker A/P-loop; other site 741091008576 ATP binding site [chemical binding]; other site 741091008577 Q-loop/lid; other site 741091008578 ABC transporter signature motif; other site 741091008579 Walker B; other site 741091008580 D-loop; other site 741091008581 H-loop/switch region; other site 741091008582 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091008583 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 741091008584 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091008585 Walker A/P-loop; other site 741091008586 ATP binding site [chemical binding]; other site 741091008587 Q-loop/lid; other site 741091008588 ABC transporter signature motif; other site 741091008589 Walker B; other site 741091008590 D-loop; other site 741091008591 H-loop/switch region; other site 741091008592 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091008593 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 741091008594 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741091008595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008596 dimer interface [polypeptide binding]; other site 741091008597 conserved gate region; other site 741091008598 putative PBP binding loops; other site 741091008599 ABC-ATPase subunit interface; other site 741091008600 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091008601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008602 dimer interface [polypeptide binding]; other site 741091008603 conserved gate region; other site 741091008604 putative PBP binding loops; other site 741091008605 ABC-ATPase subunit interface; other site 741091008606 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091008607 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 741091008608 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 741091008609 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 741091008610 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741091008611 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 741091008612 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 741091008613 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 741091008614 Ca binding site [ion binding]; other site 741091008615 active site 741091008616 catalytic site [active] 741091008617 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 741091008618 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 741091008619 Ca binding site [ion binding]; other site 741091008620 active site 741091008621 catalytic site [active] 741091008622 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 741091008623 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 741091008624 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 741091008625 Walker A/P-loop; other site 741091008626 ATP binding site [chemical binding]; other site 741091008627 Q-loop/lid; other site 741091008628 ABC transporter signature motif; other site 741091008629 Walker B; other site 741091008630 D-loop; other site 741091008631 H-loop/switch region; other site 741091008632 TOBE domain; Region: TOBE_2; pfam08402 741091008633 alpha-galactosidase; Provisional; Region: PRK15076 741091008634 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 741091008635 NAD(P) binding site [chemical binding]; other site 741091008636 LDH/MDH dimer interface [polypeptide binding]; other site 741091008637 substrate binding site [chemical binding]; other site 741091008638 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741091008639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008640 dimer interface [polypeptide binding]; other site 741091008641 conserved gate region; other site 741091008642 putative PBP binding loops; other site 741091008643 ABC-ATPase subunit interface; other site 741091008644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008645 dimer interface [polypeptide binding]; other site 741091008646 conserved gate region; other site 741091008647 putative PBP binding loops; other site 741091008648 ABC-ATPase subunit interface; other site 741091008649 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 741091008650 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 741091008651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091008652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091008653 LysR substrate binding domain; Region: LysR_substrate; pfam03466 741091008654 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 741091008655 active site turn [active] 741091008656 phosphorylation site [posttranslational modification] 741091008657 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 741091008658 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 741091008659 putative ligand binding site [chemical binding]; other site 741091008660 NAD binding site [chemical binding]; other site 741091008661 catalytic site [active] 741091008662 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 741091008663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091008664 putative substrate translocation pore; other site 741091008665 galactonate dehydratase; Provisional; Region: PRK14017 741091008666 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 741091008667 putative active site pocket [active] 741091008668 putative metal binding site [ion binding]; other site 741091008669 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 741091008670 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 741091008671 active site 741091008672 intersubunit interface [polypeptide binding]; other site 741091008673 catalytic residue [active] 741091008674 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 741091008675 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 741091008676 Transcriptional regulators [Transcription]; Region: FadR; COG2186 741091008677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091008678 DNA-binding site [nucleotide binding]; DNA binding site 741091008679 FCD domain; Region: FCD; pfam07729 741091008680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091008681 Coenzyme A binding pocket [chemical binding]; other site 741091008682 Transposase; Region: DEDD_Tnp_IS110; pfam01548 741091008683 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 741091008684 LysE type translocator; Region: LysE; cl00565 741091008685 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 741091008686 GIY-YIG motif/motif A; other site 741091008687 putative active site [active] 741091008688 putative metal binding site [ion binding]; other site 741091008689 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 741091008690 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 741091008691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091008692 DNA-binding site [nucleotide binding]; DNA binding site 741091008693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091008694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091008695 homodimer interface [polypeptide binding]; other site 741091008696 catalytic residue [active] 741091008697 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 741091008698 EamA-like transporter family; Region: EamA; pfam00892 741091008699 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 741091008700 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091008701 substrate binding pocket [chemical binding]; other site 741091008702 membrane-bound complex binding site; other site 741091008703 hinge residues; other site 741091008704 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 741091008705 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 741091008706 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 741091008707 aspartate aminotransferase; Provisional; Region: PRK05764 741091008708 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091008709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091008710 homodimer interface [polypeptide binding]; other site 741091008711 catalytic residue [active] 741091008712 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 741091008713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091008714 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 741091008715 putative dimerization interface [polypeptide binding]; other site 741091008716 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 741091008717 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 741091008718 carboxyltransferase (CT) interaction site; other site 741091008719 biotinylation site [posttranslational modification]; other site 741091008720 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 741091008721 putative active site [active] 741091008722 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 741091008723 classical (c) SDRs; Region: SDR_c; cd05233 741091008724 NAD(P) binding site [chemical binding]; other site 741091008725 active site 741091008726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008727 dimer interface [polypeptide binding]; other site 741091008728 conserved gate region; other site 741091008729 putative PBP binding loops; other site 741091008730 ABC-ATPase subunit interface; other site 741091008731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008732 dimer interface [polypeptide binding]; other site 741091008733 conserved gate region; other site 741091008734 putative PBP binding loops; other site 741091008735 ABC-ATPase subunit interface; other site 741091008736 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741091008737 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091008738 Walker A/P-loop; other site 741091008739 ATP binding site [chemical binding]; other site 741091008740 Q-loop/lid; other site 741091008741 ABC transporter signature motif; other site 741091008742 Walker B; other site 741091008743 D-loop; other site 741091008744 H-loop/switch region; other site 741091008745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 741091008746 NmrA-like family; Region: NmrA; pfam05368 741091008747 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 741091008748 NADP binding site [chemical binding]; other site 741091008749 active site 741091008750 regulatory binding site [polypeptide binding]; other site 741091008751 LysR family transcriptional regulator; Provisional; Region: PRK14997 741091008752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091008753 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 741091008754 putative effector binding pocket; other site 741091008755 dimerization interface [polypeptide binding]; other site 741091008756 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 741091008757 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 741091008758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008759 dimer interface [polypeptide binding]; other site 741091008760 conserved gate region; other site 741091008761 ABC-ATPase subunit interface; other site 741091008762 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 741091008763 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 741091008764 Walker A/P-loop; other site 741091008765 ATP binding site [chemical binding]; other site 741091008766 Q-loop/lid; other site 741091008767 ABC transporter signature motif; other site 741091008768 Walker B; other site 741091008769 D-loop; other site 741091008770 H-loop/switch region; other site 741091008771 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 741091008772 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 741091008773 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 741091008774 Sulfatase; Region: Sulfatase; cl17466 741091008775 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 741091008776 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 741091008777 Walker A/P-loop; other site 741091008778 ATP binding site [chemical binding]; other site 741091008779 Q-loop/lid; other site 741091008780 ABC transporter signature motif; other site 741091008781 Walker B; other site 741091008782 D-loop; other site 741091008783 H-loop/switch region; other site 741091008784 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 741091008785 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 741091008786 Walker A/P-loop; other site 741091008787 ATP binding site [chemical binding]; other site 741091008788 Q-loop/lid; other site 741091008789 ABC transporter signature motif; other site 741091008790 Walker B; other site 741091008791 D-loop; other site 741091008792 H-loop/switch region; other site 741091008793 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 741091008794 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 741091008795 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 741091008796 TM-ABC transporter signature motif; other site 741091008797 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091008798 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 741091008799 TM-ABC transporter signature motif; other site 741091008800 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 741091008801 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 741091008802 dimerization interface [polypeptide binding]; other site 741091008803 ligand binding site [chemical binding]; other site 741091008804 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 741091008805 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 741091008806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091008807 dimerization interface [polypeptide binding]; other site 741091008808 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091008809 dimer interface [polypeptide binding]; other site 741091008810 putative CheW interface [polypeptide binding]; other site 741091008811 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 741091008812 dimer interface [polypeptide binding]; other site 741091008813 active site 741091008814 Schiff base residues; other site 741091008815 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 741091008816 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 741091008817 putative active site [active] 741091008818 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741091008819 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 741091008820 Walker A/P-loop; other site 741091008821 ATP binding site [chemical binding]; other site 741091008822 Q-loop/lid; other site 741091008823 ABC transporter signature motif; other site 741091008824 Walker B; other site 741091008825 D-loop; other site 741091008826 H-loop/switch region; other site 741091008827 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 741091008828 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091008829 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091008830 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 741091008831 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 741091008832 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 741091008833 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 741091008834 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 741091008835 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 741091008836 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 741091008837 hypothetical protein; Provisional; Region: PRK05415 741091008838 Domain of unknown function (DUF697); Region: DUF697; cl12064 741091008839 Predicted ATPase [General function prediction only]; Region: COG3106 741091008840 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; cl11512 741091008841 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 741091008842 phage shock protein C; Region: phageshock_pspC; TIGR02978 741091008843 phage shock protein B; Provisional; Region: pspB; PRK09458 741091008844 phage shock protein PspA; Provisional; Region: PRK10698 741091008845 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 741091008846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091008847 Walker A motif; other site 741091008848 ATP binding site [chemical binding]; other site 741091008849 Walker B motif; other site 741091008850 arginine finger; other site 741091008851 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 741091008852 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 741091008853 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 741091008854 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 741091008855 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091008856 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 741091008857 peptide binding site [polypeptide binding]; other site 741091008858 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 741091008859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008860 dimer interface [polypeptide binding]; other site 741091008861 conserved gate region; other site 741091008862 putative PBP binding loops; other site 741091008863 ABC-ATPase subunit interface; other site 741091008864 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 741091008865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091008866 dimer interface [polypeptide binding]; other site 741091008867 conserved gate region; other site 741091008868 putative PBP binding loops; other site 741091008869 ABC-ATPase subunit interface; other site 741091008870 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 741091008871 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091008872 Walker A/P-loop; other site 741091008873 ATP binding site [chemical binding]; other site 741091008874 Q-loop/lid; other site 741091008875 ABC transporter signature motif; other site 741091008876 Walker B; other site 741091008877 D-loop; other site 741091008878 H-loop/switch region; other site 741091008879 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091008880 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 741091008881 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091008882 Walker A/P-loop; other site 741091008883 ATP binding site [chemical binding]; other site 741091008884 Q-loop/lid; other site 741091008885 ABC transporter signature motif; other site 741091008886 Walker B; other site 741091008887 D-loop; other site 741091008888 H-loop/switch region; other site 741091008889 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091008890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 741091008891 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 741091008892 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 741091008893 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 741091008894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091008895 putative substrate translocation pore; other site 741091008896 POT family; Region: PTR2; pfam00854 741091008897 putative acyl transferase; Provisional; Region: PRK10191 741091008898 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 741091008899 trimer interface [polypeptide binding]; other site 741091008900 active site 741091008901 substrate binding site [chemical binding]; other site 741091008902 CoA binding site [chemical binding]; other site 741091008903 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 741091008904 GAF domain; Region: GAF; pfam01590 741091008905 PAS domain S-box; Region: sensory_box; TIGR00229 741091008906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091008907 putative active site [active] 741091008908 heme pocket [chemical binding]; other site 741091008909 PAS domain S-box; Region: sensory_box; TIGR00229 741091008910 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091008911 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091008912 metal binding site [ion binding]; metal-binding site 741091008913 active site 741091008914 I-site; other site 741091008915 Helix-turn-helix domain; Region: HTH_18; pfam12833 741091008916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091008917 PAS domain; Region: PAS_9; pfam13426 741091008918 putative active site [active] 741091008919 heme pocket [chemical binding]; other site 741091008920 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091008921 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091008922 metal binding site [ion binding]; metal-binding site 741091008923 active site 741091008924 I-site; other site 741091008925 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091008926 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 741091008927 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 741091008928 dimer interface [polypeptide binding]; other site 741091008929 active site 741091008930 catalytic residue [active] 741091008931 glutathionine S-transferase; Provisional; Region: PRK10542 741091008932 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 741091008933 C-terminal domain interface [polypeptide binding]; other site 741091008934 GSH binding site (G-site) [chemical binding]; other site 741091008935 dimer interface [polypeptide binding]; other site 741091008936 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 741091008937 dimer interface [polypeptide binding]; other site 741091008938 N-terminal domain interface [polypeptide binding]; other site 741091008939 substrate binding pocket (H-site) [chemical binding]; other site 741091008940 pyridoxamine kinase; Validated; Region: PRK05756 741091008941 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 741091008942 dimer interface [polypeptide binding]; other site 741091008943 pyridoxal binding site [chemical binding]; other site 741091008944 ATP binding site [chemical binding]; other site 741091008945 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 741091008946 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 741091008947 active site 741091008948 HIGH motif; other site 741091008949 dimer interface [polypeptide binding]; other site 741091008950 KMSKS motif; other site 741091008951 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741091008952 RNA binding surface [nucleotide binding]; other site 741091008953 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 741091008954 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 741091008955 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 741091008956 lysozyme inhibitor; Provisional; Region: PRK11372 741091008957 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 741091008958 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 741091008959 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 741091008960 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 741091008961 transcriptional regulator SlyA; Provisional; Region: PRK03573 741091008962 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 741091008963 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 741091008964 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 741091008965 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091008966 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091008967 Fusaric acid resistance protein family; Region: FUSC; pfam04632 741091008968 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 741091008969 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091008970 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091008971 active site 741091008972 catalytic tetrad [active] 741091008973 Predicted Fe-S protein [General function prediction only]; Region: COG3313 741091008974 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 741091008975 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 741091008976 FMN binding site [chemical binding]; other site 741091008977 active site 741091008978 substrate binding site [chemical binding]; other site 741091008979 catalytic residue [active] 741091008980 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 741091008981 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 741091008982 dimer interface [polypeptide binding]; other site 741091008983 active site 741091008984 metal binding site [ion binding]; metal-binding site 741091008985 glutathione binding site [chemical binding]; other site 741091008986 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 741091008987 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 741091008988 dimer interface [polypeptide binding]; other site 741091008989 catalytic site [active] 741091008990 putative active site [active] 741091008991 putative substrate binding site [chemical binding]; other site 741091008992 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 741091008993 putative GSH binding site [chemical binding]; other site 741091008994 catalytic residues [active] 741091008995 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741091008996 NlpC/P60 family; Region: NLPC_P60; pfam00877 741091008997 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 741091008998 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091008999 DNA binding site [nucleotide binding] 741091009000 domain linker motif; other site 741091009001 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 741091009002 dimerization interface [polypeptide binding]; other site 741091009003 ligand binding site [chemical binding]; other site 741091009004 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 741091009005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091009006 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091009007 dimerization interface [polypeptide binding]; other site 741091009008 putative transporter; Provisional; Region: PRK11043 741091009009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091009010 putative substrate translocation pore; other site 741091009011 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 741091009012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 741091009013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091009014 S-adenosylmethionine binding site [chemical binding]; other site 741091009015 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 741091009016 Lumazine binding domain; Region: Lum_binding; pfam00677 741091009017 Lumazine binding domain; Region: Lum_binding; pfam00677 741091009018 multidrug efflux protein; Reviewed; Region: PRK01766 741091009019 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 741091009020 cation binding site [ion binding]; other site 741091009021 pyruvate kinase; Provisional; Region: PRK09206 741091009022 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 741091009023 domain interfaces; other site 741091009024 active site 741091009025 murein lipoprotein; Provisional; Region: PRK15396 741091009026 L,D-transpeptidase; Provisional; Region: PRK10190 741091009027 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 741091009028 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 741091009029 cysteine desufuration protein SufE; Provisional; Region: PRK09296 741091009030 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 741091009031 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 741091009032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741091009033 catalytic residue [active] 741091009034 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 741091009035 FeS assembly protein SufD; Region: sufD; TIGR01981 741091009036 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 741091009037 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 741091009038 Walker A/P-loop; other site 741091009039 ATP binding site [chemical binding]; other site 741091009040 Q-loop/lid; other site 741091009041 ABC transporter signature motif; other site 741091009042 Walker B; other site 741091009043 D-loop; other site 741091009044 H-loop/switch region; other site 741091009045 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 741091009046 putative ABC transporter; Region: ycf24; CHL00085 741091009047 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 741091009048 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 741091009049 CoenzymeA binding site [chemical binding]; other site 741091009050 subunit interaction site [polypeptide binding]; other site 741091009051 PHB binding site; other site 741091009052 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 741091009053 FAD binding domain; Region: FAD_binding_4; pfam01565 741091009054 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 741091009055 putative inner membrane protein; Provisional; Region: PRK10983 741091009056 Domain of unknown function DUF20; Region: UPF0118; pfam01594 741091009057 phosphoenolpyruvate synthase; Validated; Region: PRK06464 741091009058 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 741091009059 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 741091009060 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 741091009061 PEP synthetase regulatory protein; Provisional; Region: PRK05339 741091009062 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 741091009063 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 741091009064 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 741091009065 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 741091009066 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 741091009067 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 741091009068 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 741091009069 putative hemin binding site; other site 741091009070 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 741091009071 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741091009072 ABC-ATPase subunit interface; other site 741091009073 dimer interface [polypeptide binding]; other site 741091009074 putative PBP binding regions; other site 741091009075 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 741091009076 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 741091009077 Walker A/P-loop; other site 741091009078 ATP binding site [chemical binding]; other site 741091009079 Q-loop/lid; other site 741091009080 ABC transporter signature motif; other site 741091009081 Walker B; other site 741091009082 D-loop; other site 741091009083 H-loop/switch region; other site 741091009084 Uncharacterized conserved protein [Function unknown]; Region: COG0397 741091009085 hypothetical protein; Validated; Region: PRK00029 741091009086 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 741091009087 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 741091009088 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 741091009089 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 741091009090 NlpC/P60 family; Region: NLPC_P60; pfam00877 741091009091 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 741091009092 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 741091009093 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 741091009094 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 741091009095 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 741091009096 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 741091009097 putative active site [active] 741091009098 putative catalytic site [active] 741091009099 putative Zn binding site [ion binding]; other site 741091009100 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 741091009101 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 741091009102 active site 741091009103 substrate binding site [chemical binding]; other site 741091009104 cosubstrate binding site; other site 741091009105 catalytic site [active] 741091009106 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 741091009107 active site 741091009108 hexamer interface [polypeptide binding]; other site 741091009109 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 741091009110 NAD binding site [chemical binding]; other site 741091009111 substrate binding site [chemical binding]; other site 741091009112 active site 741091009113 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 741091009114 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 741091009115 Ligand binding site; other site 741091009116 Putative Catalytic site; other site 741091009117 DXD motif; other site 741091009118 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 741091009119 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 741091009120 inhibitor-cofactor binding pocket; inhibition site 741091009121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091009122 catalytic residue [active] 741091009123 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 741091009124 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 741091009125 Walker A/P-loop; other site 741091009126 ATP binding site [chemical binding]; other site 741091009127 Q-loop/lid; other site 741091009128 ABC transporter signature motif; other site 741091009129 Walker B; other site 741091009130 D-loop; other site 741091009131 H-loop/switch region; other site 741091009132 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 741091009133 catalytic residues [active] 741091009134 dimer interface [polypeptide binding]; other site 741091009135 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 741091009136 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741091009137 ABC-ATPase subunit interface; other site 741091009138 dimer interface [polypeptide binding]; other site 741091009139 putative PBP binding regions; other site 741091009140 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 741091009141 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 741091009142 IHF dimer interface [polypeptide binding]; other site 741091009143 IHF - DNA interface [nucleotide binding]; other site 741091009144 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 741091009145 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 741091009146 putative tRNA-binding site [nucleotide binding]; other site 741091009147 B3/4 domain; Region: B3_4; pfam03483 741091009148 tRNA synthetase B5 domain; Region: B5; smart00874 741091009149 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 741091009150 dimer interface [polypeptide binding]; other site 741091009151 motif 1; other site 741091009152 motif 3; other site 741091009153 motif 2; other site 741091009154 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 741091009155 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 741091009156 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 741091009157 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 741091009158 dimer interface [polypeptide binding]; other site 741091009159 motif 1; other site 741091009160 active site 741091009161 motif 2; other site 741091009162 motif 3; other site 741091009163 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 741091009164 23S rRNA binding site [nucleotide binding]; other site 741091009165 L21 binding site [polypeptide binding]; other site 741091009166 L13 binding site [polypeptide binding]; other site 741091009167 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 741091009168 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 741091009169 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 741091009170 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 741091009171 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 741091009172 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 741091009173 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 741091009174 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 741091009175 active site 741091009176 dimer interface [polypeptide binding]; other site 741091009177 motif 1; other site 741091009178 motif 2; other site 741091009179 motif 3; other site 741091009180 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 741091009181 anticodon binding site; other site 741091009182 inner membrane protein; Provisional; Region: PRK10995 741091009183 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 741091009184 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741091009185 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741091009186 catalytic residue [active] 741091009187 Phosphotransferase enzyme family; Region: APH; pfam01636 741091009188 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 741091009189 active site 741091009190 ATP binding site [chemical binding]; other site 741091009191 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 741091009192 YniB-like protein; Region: YniB; pfam14002 741091009193 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 741091009194 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 741091009195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091009196 motif II; other site 741091009197 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 741091009198 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 741091009199 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 741091009200 NADP binding site [chemical binding]; other site 741091009201 homodimer interface [polypeptide binding]; other site 741091009202 active site 741091009203 inner membrane protein; Provisional; Region: PRK11648 741091009204 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 741091009205 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 741091009206 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 741091009207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091009208 dimerization interface [polypeptide binding]; other site 741091009209 putative Zn2+ binding site [ion binding]; other site 741091009210 putative DNA binding site [nucleotide binding]; other site 741091009211 Bacterial transcriptional regulator; Region: IclR; pfam01614 741091009212 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 741091009213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091009214 putative substrate translocation pore; other site 741091009215 heat shock protein HtpX; Provisional; Region: PRK05457 741091009216 carboxy-terminal protease; Provisional; Region: PRK11186 741091009217 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 741091009218 protein binding site [polypeptide binding]; other site 741091009219 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 741091009220 Catalytic dyad [active] 741091009221 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 741091009222 ProP expression regulator; Provisional; Region: PRK04950 741091009223 ProQ/FINO family; Region: ProQ; pfam04352 741091009224 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 741091009225 GAF domain; Region: GAF_2; pfam13185 741091009226 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 741091009227 Paraquat-inducible protein A; Region: PqiA; pfam04403 741091009228 Paraquat-inducible protein A; Region: PqiA; pfam04403 741091009229 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 741091009230 mce related protein; Region: MCE; pfam02470 741091009231 mce related protein; Region: MCE; pfam02470 741091009232 mce related protein; Region: MCE; pfam02470 741091009233 mce related protein; Region: MCE; pfam02470 741091009234 mce related protein; Region: MCE; pfam02470 741091009235 mce related protein; Region: MCE; pfam02470 741091009236 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 741091009237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091009238 S-adenosylmethionine binding site [chemical binding]; other site 741091009239 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 741091009240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091009241 PAS domain; Region: PAS_9; pfam13426 741091009242 putative active site [active] 741091009243 heme pocket [chemical binding]; other site 741091009244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091009245 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 741091009246 putative active site [active] 741091009247 heme pocket [chemical binding]; other site 741091009248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091009249 putative active site [active] 741091009250 heme pocket [chemical binding]; other site 741091009251 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091009252 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091009253 metal binding site [ion binding]; metal-binding site 741091009254 active site 741091009255 I-site; other site 741091009256 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 741091009257 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 741091009258 KWG Leptospira; Region: KWG; pfam07656 741091009259 KWG Leptospira; Region: KWG; pfam07656 741091009260 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 741091009261 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 741091009262 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 741091009263 metal binding site [ion binding]; metal-binding site 741091009264 putative dimer interface [polypeptide binding]; other site 741091009265 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 741091009266 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 741091009267 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 741091009268 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 741091009269 HAMP domain; Region: HAMP; pfam00672 741091009270 dimerization interface [polypeptide binding]; other site 741091009271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091009272 dimer interface [polypeptide binding]; other site 741091009273 putative CheW interface [polypeptide binding]; other site 741091009274 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 741091009275 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 741091009276 Divergent AAA domain; Region: AAA_4; pfam04326 741091009277 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 741091009278 HTH-like domain; Region: HTH_21; pfam13276 741091009279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 741091009280 Integrase core domain; Region: rve; pfam00665 741091009281 Integrase core domain; Region: rve_3; pfam13683 741091009282 Transposase; Region: HTH_Tnp_1; pfam01527 741091009283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091009284 Coenzyme A binding pocket [chemical binding]; other site 741091009285 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 741091009286 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 741091009287 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 741091009288 CopC domain; Region: CopC; cl01012 741091009289 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 741091009290 Ferritin-like domain; Region: Ferritin; pfam00210 741091009291 ferroxidase diiron center [ion binding]; other site 741091009292 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 741091009293 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 741091009294 protease 2; Provisional; Region: PRK10115 741091009295 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741091009296 YebF-like protein; Region: YebF; cl10126 741091009297 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 741091009298 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 741091009299 ATP binding site [chemical binding]; other site 741091009300 putative Mg++ binding site [ion binding]; other site 741091009301 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091009302 nucleotide binding region [chemical binding]; other site 741091009303 ATP-binding site [chemical binding]; other site 741091009304 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 741091009305 putative RNA binding site [nucleotide binding]; other site 741091009306 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 741091009307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091009308 ATP-grasp domain; Region: ATP-grasp; pfam02222 741091009309 hypothetical protein; Provisional; Region: PRK05114 741091009310 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 741091009311 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 741091009312 chorismate binding enzyme; Region: Chorismate_bind; cl10555 741091009313 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 741091009314 putative active site [active] 741091009315 putative CoA binding site [chemical binding]; other site 741091009316 nudix motif; other site 741091009317 metal binding site [ion binding]; metal-binding site 741091009318 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 741091009319 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 741091009320 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 741091009321 phage resistance protein; Provisional; Region: PRK10551 741091009322 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 741091009323 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091009324 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 741091009325 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 741091009326 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 741091009327 Transporter associated domain; Region: CorC_HlyC; smart01091 741091009328 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 741091009329 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 741091009330 active pocket/dimerization site; other site 741091009331 active site 741091009332 phosphorylation site [posttranslational modification] 741091009333 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 741091009334 active site 741091009335 phosphorylation site [posttranslational modification] 741091009336 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 741091009337 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 741091009338 hypothetical protein; Provisional; Region: PRK02913 741091009339 hypothetical protein; Provisional; Region: PRK11469 741091009340 Domain of unknown function DUF; Region: DUF204; pfam02659 741091009341 Domain of unknown function DUF; Region: DUF204; pfam02659 741091009342 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 741091009343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091009344 S-adenosylmethionine binding site [chemical binding]; other site 741091009345 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 741091009346 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 741091009347 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741091009348 DNA-binding site [nucleotide binding]; DNA binding site 741091009349 RNA-binding motif; other site 741091009350 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 741091009351 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 741091009352 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 741091009353 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 741091009354 YebO-like protein; Region: YebO; pfam13974 741091009355 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 741091009356 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741091009357 Autotransporter beta-domain; Region: Autotransporter; pfam03797 741091009358 YobH-like protein; Region: YobH; pfam13996 741091009359 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 741091009360 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 741091009361 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 741091009362 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 741091009363 peptide binding site [polypeptide binding]; other site 741091009364 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 741091009365 isocitrate dehydrogenase; Validated; Region: PRK06451 741091009366 isocitrate dehydrogenase; Reviewed; Region: PRK07006 741091009367 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 741091009368 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 741091009369 probable active site [active] 741091009370 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 741091009371 nudix motif; other site 741091009372 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 741091009373 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 741091009374 putative lysogenization regulator; Reviewed; Region: PRK00218 741091009375 adenylosuccinate lyase; Provisional; Region: PRK09285 741091009376 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 741091009377 tetramer interface [polypeptide binding]; other site 741091009378 active site 741091009379 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 741091009380 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741091009381 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 741091009382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 741091009383 Transposase; Region: DEDD_Tnp_IS110; pfam01548 741091009384 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 741091009385 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 741091009386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091009387 active site 741091009388 phosphorylation site [posttranslational modification] 741091009389 intermolecular recognition site; other site 741091009390 dimerization interface [polypeptide binding]; other site 741091009391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091009392 DNA binding site [nucleotide binding] 741091009393 sensor protein PhoQ; Provisional; Region: PRK10815 741091009394 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 741091009395 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 741091009396 dimer interface [polypeptide binding]; other site 741091009397 phosphorylation site [posttranslational modification] 741091009398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091009399 ATP binding site [chemical binding]; other site 741091009400 Mg2+ binding site [ion binding]; other site 741091009401 G-X-G motif; other site 741091009402 Uncharacterized conserved protein [Function unknown]; Region: COG2850 741091009403 Transposase; Region: DEDD_Tnp_IS110; pfam01548 741091009404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 741091009405 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 741091009406 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 741091009407 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 741091009408 metal binding site [ion binding]; metal-binding site 741091009409 dimer interface [polypeptide binding]; other site 741091009410 NAD-dependent deacetylase; Provisional; Region: PRK00481 741091009411 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 741091009412 NAD+ binding site [chemical binding]; other site 741091009413 substrate binding site [chemical binding]; other site 741091009414 Zn binding site [ion binding]; other site 741091009415 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 741091009416 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 741091009417 FtsX-like permease family; Region: FtsX; pfam02687 741091009418 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 741091009419 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 741091009420 Walker A/P-loop; other site 741091009421 ATP binding site [chemical binding]; other site 741091009422 Q-loop/lid; other site 741091009423 ABC transporter signature motif; other site 741091009424 Walker B; other site 741091009425 D-loop; other site 741091009426 H-loop/switch region; other site 741091009427 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 741091009428 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 741091009429 FtsX-like permease family; Region: FtsX; pfam02687 741091009430 transcription-repair coupling factor; Provisional; Region: PRK10689 741091009431 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 741091009432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741091009433 ATP binding site [chemical binding]; other site 741091009434 putative Mg++ binding site [ion binding]; other site 741091009435 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091009436 nucleotide binding region [chemical binding]; other site 741091009437 ATP-binding site [chemical binding]; other site 741091009438 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 741091009439 hypothetical protein; Provisional; Region: PRK11280 741091009440 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 741091009441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741091009442 hypothetical protein; Provisional; Region: PRK04940 741091009443 beta-hexosaminidase; Provisional; Region: PRK05337 741091009444 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 741091009445 thiamine kinase; Region: ycfN_thiK; TIGR02721 741091009446 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 741091009447 active site 741091009448 substrate binding site [chemical binding]; other site 741091009449 ATP binding site [chemical binding]; other site 741091009450 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 741091009451 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 741091009452 murein hydrolase B; Provisional; Region: PRK10760; cl17906 741091009453 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 741091009454 putative dimer interface [polypeptide binding]; other site 741091009455 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 741091009456 nucleotide binding site/active site [active] 741091009457 HIT family signature motif; other site 741091009458 catalytic residue [active] 741091009459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 741091009460 Transposase; Region: DEDD_Tnp_IS110; pfam01548 741091009461 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 741091009462 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 741091009463 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741091009464 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741091009465 active site turn [active] 741091009466 phosphorylation site [posttranslational modification] 741091009467 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 741091009468 active site 741091009469 DNA polymerase III subunit delta'; Validated; Region: PRK07993 741091009470 DNA polymerase III subunit delta'; Validated; Region: PRK08485 741091009471 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 741091009472 thymidylate kinase; Validated; Region: tmk; PRK00698 741091009473 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 741091009474 TMP-binding site; other site 741091009475 ATP-binding site [chemical binding]; other site 741091009476 YceG-like family; Region: YceG; pfam02618 741091009477 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 741091009478 dimerization interface [polypeptide binding]; other site 741091009479 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 741091009480 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 741091009481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091009482 catalytic residue [active] 741091009483 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 741091009484 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 741091009485 dimer interface [polypeptide binding]; other site 741091009486 active site 741091009487 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 741091009488 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 741091009489 NAD(P) binding site [chemical binding]; other site 741091009490 homotetramer interface [polypeptide binding]; other site 741091009491 homodimer interface [polypeptide binding]; other site 741091009492 active site 741091009493 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 741091009494 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 741091009495 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 741091009496 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 741091009497 dimer interface [polypeptide binding]; other site 741091009498 active site 741091009499 CoA binding pocket [chemical binding]; other site 741091009500 putative phosphate acyltransferase; Provisional; Region: PRK05331 741091009501 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 741091009502 hypothetical protein; Provisional; Region: PRK11193 741091009503 Maf-like protein; Region: Maf; pfam02545 741091009504 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 741091009505 active site 741091009506 dimer interface [polypeptide binding]; other site 741091009507 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 741091009508 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741091009509 RNA binding surface [nucleotide binding]; other site 741091009510 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 741091009511 active site 741091009512 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 741091009513 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 741091009514 homodimer interface [polypeptide binding]; other site 741091009515 oligonucleotide binding site [chemical binding]; other site 741091009516 Uncharacterized conserved protein [Function unknown]; Region: COG1359 741091009517 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 741091009518 active site 741091009519 substrate binding pocket [chemical binding]; other site 741091009520 dimer interface [polypeptide binding]; other site 741091009521 DNA damage-inducible protein I; Provisional; Region: PRK10597 741091009522 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 741091009523 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 741091009524 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 741091009525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741091009526 DNA binding residues [nucleotide binding] 741091009527 dimerization interface [polypeptide binding]; other site 741091009528 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 741091009529 Domain of unknown function DUF20; Region: UPF0118; pfam01594 741091009530 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 741091009531 Protein export membrane protein; Region: SecD_SecF; cl14618 741091009532 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 741091009533 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091009534 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091009535 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 741091009536 hypothetical protein; Provisional; Region: PRK03757 741091009537 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 741091009538 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 741091009539 active site residue [active] 741091009540 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 741091009541 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 741091009542 active site 741091009543 FMN binding site [chemical binding]; other site 741091009544 substrate binding site [chemical binding]; other site 741091009545 homotetramer interface [polypeptide binding]; other site 741091009546 catalytic residue [active] 741091009547 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 741091009548 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 741091009549 putative acyl-acceptor binding pocket; other site 741091009550 DoxX; Region: DoxX; pfam07681 741091009551 drug efflux system protein MdtG; Provisional; Region: PRK09874 741091009552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091009553 putative substrate translocation pore; other site 741091009554 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 741091009555 MsyB protein; Region: MsyB; cl08181 741091009556 lipoprotein; Provisional; Region: PRK10175 741091009557 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 741091009558 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 741091009559 Ligand binding site; other site 741091009560 DXD motif; other site 741091009561 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 741091009562 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 741091009563 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 741091009564 Acyltransferase family; Region: Acyl_transf_3; pfam01757 741091009565 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 741091009566 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091009567 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091009568 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 741091009569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091009570 putative substrate translocation pore; other site 741091009571 Transcriptional regulator [Transcription]; Region: IclR; COG1414 741091009572 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091009573 putative DNA binding site [nucleotide binding]; other site 741091009574 putative Zn2+ binding site [ion binding]; other site 741091009575 Bacterial transcriptional regulator; Region: IclR; pfam01614 741091009576 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 741091009577 Ligand Binding Site [chemical binding]; other site 741091009578 YccJ-like protein; Region: YccJ; cl08091 741091009579 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 741091009580 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 741091009581 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 741091009582 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 741091009583 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741091009584 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 741091009585 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741091009586 active site 741091009587 metal binding site [ion binding]; metal-binding site 741091009588 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 741091009589 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 741091009590 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 741091009591 GIY-YIG motif/motif A; other site 741091009592 active site 741091009593 catalytic site [active] 741091009594 putative DNA binding site [nucleotide binding]; other site 741091009595 metal binding site [ion binding]; metal-binding site 741091009596 UvrB/uvrC motif; Region: UVR; pfam02151 741091009597 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 741091009598 response regulator; Provisional; Region: PRK09483 741091009599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091009600 active site 741091009601 phosphorylation site [posttranslational modification] 741091009602 intermolecular recognition site; other site 741091009603 dimerization interface [polypeptide binding]; other site 741091009604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741091009605 DNA binding residues [nucleotide binding] 741091009606 dimerization interface [polypeptide binding]; other site 741091009607 hypothetical protein; Provisional; Region: PRK10613 741091009608 Cupin domain; Region: Cupin_2; cl17218 741091009609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091009610 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091009611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091009612 2-isopropylmalate synthase; Validated; Region: PRK03739 741091009613 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 741091009614 active site 741091009615 catalytic residues [active] 741091009616 metal binding site [ion binding]; metal-binding site 741091009617 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 741091009618 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 741091009619 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 741091009620 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 741091009621 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 741091009622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 741091009623 Putative glucoamylase; Region: Glycoamylase; pfam10091 741091009624 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 741091009625 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 741091009626 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091009627 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 741091009628 pyrimidine utilization protein A; Region: RutA; TIGR03612 741091009629 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 741091009630 active site 741091009631 dimer interface [polypeptide binding]; other site 741091009632 non-prolyl cis peptide bond; other site 741091009633 insertion regions; other site 741091009634 Isochorismatase family; Region: Isochorismatase; pfam00857 741091009635 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 741091009636 catalytic triad [active] 741091009637 conserved cis-peptide bond; other site 741091009638 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 741091009639 homotrimer interaction site [polypeptide binding]; other site 741091009640 putative active site [active] 741091009641 pyrimidine utilization protein D; Region: RutD; TIGR03611 741091009642 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 741091009643 putative FMN binding site [chemical binding]; other site 741091009644 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 741091009645 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 741091009646 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091009647 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 741091009648 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091009649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091009650 dimer interface [polypeptide binding]; other site 741091009651 conserved gate region; other site 741091009652 putative PBP binding loops; other site 741091009653 ABC-ATPase subunit interface; other site 741091009654 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091009655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091009656 putative PBP binding loops; other site 741091009657 ABC-ATPase subunit interface; other site 741091009658 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 741091009659 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091009660 Walker A/P-loop; other site 741091009661 ATP binding site [chemical binding]; other site 741091009662 Q-loop/lid; other site 741091009663 ABC transporter signature motif; other site 741091009664 Walker B; other site 741091009665 D-loop; other site 741091009666 H-loop/switch region; other site 741091009667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091009668 Walker A/P-loop; other site 741091009669 ATP binding site [chemical binding]; other site 741091009670 Q-loop/lid; other site 741091009671 ABC transporter signature motif; other site 741091009672 Walker B; other site 741091009673 D-loop; other site 741091009674 H-loop/switch region; other site 741091009675 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 741091009676 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 741091009677 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 741091009678 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 741091009679 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 741091009680 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 741091009681 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 741091009682 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741091009683 Walker A/P-loop; other site 741091009684 ATP binding site [chemical binding]; other site 741091009685 Q-loop/lid; other site 741091009686 ABC transporter signature motif; other site 741091009687 Walker B; other site 741091009688 D-loop; other site 741091009689 H-loop/switch region; other site 741091009690 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741091009691 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091009692 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091009693 TM-ABC transporter signature motif; other site 741091009694 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 741091009695 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 741091009696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091009697 Coenzyme A binding pocket [chemical binding]; other site 741091009698 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 741091009699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091009700 sequence-specific DNA binding site [nucleotide binding]; other site 741091009701 salt bridge; other site 741091009702 Cupin domain; Region: Cupin_2; cl17218 741091009703 transcriptional regulator MirA; Provisional; Region: PRK15043 741091009704 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 741091009705 DNA binding residues [nucleotide binding] 741091009706 SnoaL-like domain; Region: SnoaL_2; pfam12680 741091009707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091009708 NAD(P) binding site [chemical binding]; other site 741091009709 active site 741091009710 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 741091009711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 741091009712 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 741091009713 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 741091009714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091009715 S-adenosylmethionine binding site [chemical binding]; other site 741091009716 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 741091009717 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 741091009718 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 741091009719 EamA-like transporter family; Region: EamA; pfam00892 741091009720 EamA-like transporter family; Region: EamA; pfam00892 741091009721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091009722 putative PBP binding loops; other site 741091009723 dimer interface [polypeptide binding]; other site 741091009724 ABC-ATPase subunit interface; other site 741091009725 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 741091009726 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 741091009727 Walker A/P-loop; other site 741091009728 ATP binding site [chemical binding]; other site 741091009729 Q-loop/lid; other site 741091009730 ABC transporter signature motif; other site 741091009731 Walker B; other site 741091009732 D-loop; other site 741091009733 H-loop/switch region; other site 741091009734 CBS domain; Region: CBS; pfam00571 741091009735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091009736 dimer interface [polypeptide binding]; other site 741091009737 conserved gate region; other site 741091009738 ABC-ATPase subunit interface; other site 741091009739 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 741091009740 benzoate transport; Region: 2A0115; TIGR00895 741091009741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091009742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091009743 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 741091009744 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 741091009745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091009746 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091009747 dimerization interface [polypeptide binding]; other site 741091009748 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 741091009749 amidohydrolase; Region: amidohydrolases; TIGR01891 741091009750 putative metal binding site [ion binding]; other site 741091009751 dimer interface [polypeptide binding]; other site 741091009752 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 741091009753 amidohydrolase; Region: amidohydrolases; TIGR01891 741091009754 putative metal binding site [ion binding]; other site 741091009755 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 741091009756 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 741091009757 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 741091009758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091009759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091009760 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741091009761 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741091009762 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741091009763 H+ Antiporter protein; Region: 2A0121; TIGR00900 741091009764 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 741091009765 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 741091009766 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 741091009767 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 741091009768 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 741091009769 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 741091009770 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 741091009771 NAD(P) binding site [chemical binding]; other site 741091009772 catalytic residues [active] 741091009773 Uncharacterized conserved protein [Function unknown]; Region: COG2850 741091009774 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 741091009775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091009776 dimer interface [polypeptide binding]; other site 741091009777 conserved gate region; other site 741091009778 putative PBP binding loops; other site 741091009779 ABC-ATPase subunit interface; other site 741091009780 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 741091009781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091009782 dimer interface [polypeptide binding]; other site 741091009783 conserved gate region; other site 741091009784 putative PBP binding loops; other site 741091009785 ABC-ATPase subunit interface; other site 741091009786 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 741091009787 Transferrin; Region: Transferrin; cl02460 741091009788 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 741091009789 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 741091009790 Walker A/P-loop; other site 741091009791 ATP binding site [chemical binding]; other site 741091009792 Q-loop/lid; other site 741091009793 ABC transporter signature motif; other site 741091009794 Walker B; other site 741091009795 D-loop; other site 741091009796 H-loop/switch region; other site 741091009797 D-lactate dehydrogenase; Provisional; Region: PRK11183 741091009798 FAD binding domain; Region: FAD_binding_4; pfam01565 741091009799 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 741091009800 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 741091009801 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 741091009802 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 741091009803 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 741091009804 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 741091009805 FMN binding site [chemical binding]; other site 741091009806 active site 741091009807 catalytic residues [active] 741091009808 substrate binding site [chemical binding]; other site 741091009809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091009810 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741091009811 putative substrate translocation pore; other site 741091009812 Predicted transcriptional regulator [Transcription]; Region: COG2345 741091009813 Transcriptional regulator PadR-like family; Region: PadR; cl17335 741091009814 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 741091009815 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 741091009816 ATP binding site [chemical binding]; other site 741091009817 Mg++ binding site [ion binding]; other site 741091009818 motif III; other site 741091009819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091009820 nucleotide binding region [chemical binding]; other site 741091009821 ATP-binding site [chemical binding]; other site 741091009822 drug efflux system protein MdtG; Provisional; Region: PRK09874 741091009823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091009824 putative substrate translocation pore; other site 741091009825 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 741091009826 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 741091009827 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 741091009828 MoaE homodimer interface [polypeptide binding]; other site 741091009829 MoaD interaction [polypeptide binding]; other site 741091009830 active site residues [active] 741091009831 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 741091009832 MoaE interaction surface [polypeptide binding]; other site 741091009833 MoeB interaction surface [polypeptide binding]; other site 741091009834 thiocarboxylated glycine; other site 741091009835 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 741091009836 trimer interface [polypeptide binding]; other site 741091009837 dimer interface [polypeptide binding]; other site 741091009838 putative active site [active] 741091009839 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 741091009840 MPT binding site; other site 741091009841 trimer interface [polypeptide binding]; other site 741091009842 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 741091009843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091009844 FeS/SAM binding site; other site 741091009845 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 741091009846 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 741091009847 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 741091009848 phosphate binding site [ion binding]; other site 741091009849 putative substrate binding pocket [chemical binding]; other site 741091009850 dimer interface [polypeptide binding]; other site 741091009851 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 741091009852 Isochorismatase family; Region: Isochorismatase; pfam00857 741091009853 catalytic triad [active] 741091009854 conserved cis-peptide bond; other site 741091009855 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 741091009856 excinuclease ABC subunit B; Provisional; Region: PRK05298 741091009857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741091009858 ATP binding site [chemical binding]; other site 741091009859 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091009860 nucleotide binding region [chemical binding]; other site 741091009861 ATP-binding site [chemical binding]; other site 741091009862 Ultra-violet resistance protein B; Region: UvrB; pfam12344 741091009863 UvrB/uvrC motif; Region: UVR; pfam02151 741091009864 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 741091009865 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 741091009866 Walker A/P-loop; other site 741091009867 ATP binding site [chemical binding]; other site 741091009868 Q-loop/lid; other site 741091009869 ABC transporter signature motif; other site 741091009870 Walker B; other site 741091009871 D-loop; other site 741091009872 H-loop/switch region; other site 741091009873 AAA domain; Region: AAA_26; pfam13500 741091009874 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 741091009875 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 741091009876 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 741091009877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091009878 S-adenosylmethionine binding site [chemical binding]; other site 741091009879 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 741091009880 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 741091009881 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741091009882 catalytic residue [active] 741091009883 biotin synthase; Provisional; Region: PRK15108 741091009884 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091009885 FeS/SAM binding site; other site 741091009886 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 741091009887 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 741091009888 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741091009889 inhibitor-cofactor binding pocket; inhibition site 741091009890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091009891 catalytic residue [active] 741091009892 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 741091009893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091009894 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 741091009895 dimerization interface [polypeptide binding]; other site 741091009896 substrate binding pocket [chemical binding]; other site 741091009897 putative aminotransferase; Provisional; Region: PRK12414 741091009898 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091009899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091009900 homodimer interface [polypeptide binding]; other site 741091009901 catalytic residue [active] 741091009902 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 741091009903 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091009904 substrate binding pocket [chemical binding]; other site 741091009905 membrane-bound complex binding site; other site 741091009906 hinge residues; other site 741091009907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091009908 active site 741091009909 motif I; other site 741091009910 motif II; other site 741091009911 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 741091009912 Prostaglandin dehydrogenases; Region: PGDH; cd05288 741091009913 NAD(P) binding site [chemical binding]; other site 741091009914 substrate binding site [chemical binding]; other site 741091009915 dimer interface [polypeptide binding]; other site 741091009916 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 741091009917 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 741091009918 potential catalytic triad [active] 741091009919 conserved cys residue [active] 741091009920 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 741091009921 substrate binding site [chemical binding]; other site 741091009922 acyl-CoA thioesterase; Provisional; Region: PRK10531 741091009923 putative pectinesterase; Region: PLN02432; cl01911 741091009924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091009925 dimerization interface [polypeptide binding]; other site 741091009926 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 741091009927 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091009928 dimer interface [polypeptide binding]; other site 741091009929 putative CheW interface [polypeptide binding]; other site 741091009930 6-phosphogluconolactonase; Provisional; Region: PRK11028 741091009931 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 741091009932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091009933 active site 741091009934 motif I; other site 741091009935 motif II; other site 741091009936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091009937 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 741091009938 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 741091009939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091009940 non-specific DNA binding site [nucleotide binding]; other site 741091009941 salt bridge; other site 741091009942 sequence-specific DNA binding site [nucleotide binding]; other site 741091009943 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 741091009944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091009945 Walker A/P-loop; other site 741091009946 ATP binding site [chemical binding]; other site 741091009947 Q-loop/lid; other site 741091009948 ABC transporter signature motif; other site 741091009949 Walker B; other site 741091009950 D-loop; other site 741091009951 H-loop/switch region; other site 741091009952 TOBE domain; Region: TOBE; pfam03459 741091009953 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 741091009954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091009955 dimer interface [polypeptide binding]; other site 741091009956 conserved gate region; other site 741091009957 putative PBP binding loops; other site 741091009958 ABC-ATPase subunit interface; other site 741091009959 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 741091009960 molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256 741091009961 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 741091009962 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 741091009963 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 741091009964 molybdenum-pterin binding domain; Region: Mop; TIGR00638 741091009965 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 741091009966 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 741091009967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091009968 Walker A/P-loop; other site 741091009969 ATP binding site [chemical binding]; other site 741091009970 Q-loop/lid; other site 741091009971 ABC transporter signature motif; other site 741091009972 Walker B; other site 741091009973 D-loop; other site 741091009974 H-loop/switch region; other site 741091009975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091009976 Walker A/P-loop; other site 741091009977 ATP binding site [chemical binding]; other site 741091009978 Q-loop/lid; other site 741091009979 ABC transporter signature motif; other site 741091009980 Walker B; other site 741091009981 D-loop; other site 741091009982 H-loop/switch region; other site 741091009983 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 741091009984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091009985 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091009986 dimerization interface [polypeptide binding]; other site 741091009987 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 741091009988 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 741091009989 NAD binding site [chemical binding]; other site 741091009990 homodimer interface [polypeptide binding]; other site 741091009991 active site 741091009992 substrate binding site [chemical binding]; other site 741091009993 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 741091009994 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 741091009995 dimer interface [polypeptide binding]; other site 741091009996 active site 741091009997 galactokinase; Provisional; Region: PRK05101 741091009998 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 741091009999 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 741091010000 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 741091010001 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 741091010002 active site 741091010003 catalytic residues [active] 741091010004 psiF repeat; Region: PsiF_repeat; pfam07769 741091010005 psiF repeat; Region: PsiF_repeat; pfam07769 741091010006 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 741091010007 catalytic core [active] 741091010008 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 741091010009 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 741091010010 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 741091010011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091010012 Coenzyme A binding pocket [chemical binding]; other site 741091010013 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 741091010014 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 741091010015 YbgS-like protein; Region: YbgS; pfam13985 741091010016 Cation efflux family; Region: Cation_efflux; cl00316 741091010017 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 741091010018 quinolinate synthetase; Provisional; Region: PRK09375 741091010019 tol-pal system protein YbgF; Provisional; Region: PRK10803 741091010020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 741091010021 binding surface 741091010022 TPR motif; other site 741091010023 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 741091010024 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741091010025 ligand binding site [chemical binding]; other site 741091010026 translocation protein TolB; Provisional; Region: tolB; PRK03629 741091010027 TolB amino-terminal domain; Region: TolB_N; pfam04052 741091010028 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 741091010029 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 741091010030 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 741091010031 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 741091010032 TolA C-terminal; Region: TolA; pfam06519 741091010033 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 741091010034 colicin uptake protein TolR; Provisional; Region: PRK11024 741091010035 colicin uptake protein TolQ; Provisional; Region: PRK10801 741091010036 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 741091010037 active site 741091010038 hypothetical protein; Provisional; Region: PRK10588 741091010039 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 741091010040 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 741091010041 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 741091010042 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 741091010043 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 741091010044 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 741091010045 CoA binding domain; Region: CoA_binding; smart00881 741091010046 CoA-ligase; Region: Ligase_CoA; pfam00549 741091010047 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 741091010048 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 741091010049 CoA-ligase; Region: Ligase_CoA; pfam00549 741091010050 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 741091010051 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 741091010052 E3 interaction surface; other site 741091010053 lipoyl attachment site [posttranslational modification]; other site 741091010054 e3 binding domain; Region: E3_binding; pfam02817 741091010055 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 741091010056 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 741091010057 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 741091010058 TPP-binding site [chemical binding]; other site 741091010059 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 741091010060 dimer interface [polypeptide binding]; other site 741091010061 PYR/PP interface [polypeptide binding]; other site 741091010062 TPP binding site [chemical binding]; other site 741091010063 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 741091010064 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 741091010065 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 741091010066 L-aspartate oxidase; Provisional; Region: PRK06175 741091010067 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 741091010068 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 741091010069 SdhC subunit interface [polypeptide binding]; other site 741091010070 proximal heme binding site [chemical binding]; other site 741091010071 cardiolipin binding site; other site 741091010072 Iron-sulfur protein interface; other site 741091010073 proximal quinone binding site [chemical binding]; other site 741091010074 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 741091010075 Iron-sulfur protein interface; other site 741091010076 proximal quinone binding site [chemical binding]; other site 741091010077 SdhD (CybS) interface [polypeptide binding]; other site 741091010078 proximal heme binding site [chemical binding]; other site 741091010079 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 741091010080 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 741091010081 dimer interface [polypeptide binding]; other site 741091010082 active site 741091010083 citrylCoA binding site [chemical binding]; other site 741091010084 NADH binding [chemical binding]; other site 741091010085 cationic pore residues; other site 741091010086 oxalacetate/citrate binding site [chemical binding]; other site 741091010087 coenzyme A binding site [chemical binding]; other site 741091010088 catalytic triad [active] 741091010089 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 741091010090 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741091010091 Autotransporter beta-domain; Region: Autotransporter; smart00869 741091010092 endonuclease VIII; Provisional; Region: PRK10445 741091010093 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 741091010094 DNA binding site [nucleotide binding] 741091010095 catalytic residue [active] 741091010096 H2TH interface [polypeptide binding]; other site 741091010097 putative catalytic residues [active] 741091010098 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 741091010099 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 741091010100 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 741091010101 putative substrate binding pocket [chemical binding]; other site 741091010102 AC domain interface; other site 741091010103 catalytic triad [active] 741091010104 AB domain interface; other site 741091010105 interchain disulfide; other site 741091010106 LamB/YcsF family protein; Provisional; Region: PRK05406 741091010107 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 741091010108 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 741091010109 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 741091010110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091010111 putative substrate translocation pore; other site 741091010112 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741091010113 Uncharacterized conserved protein [Function unknown]; Region: COG0327 741091010114 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 741091010115 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 741091010116 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 741091010117 DNA photolyase; Region: DNA_photolyase; pfam00875 741091010118 Protein of unknown function (DUF523); Region: DUF523; pfam04463 741091010119 Uncharacterized conserved protein [Function unknown]; Region: COG3272 741091010120 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 741091010121 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 741091010122 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 741091010123 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 741091010124 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 741091010125 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 741091010126 sensor protein KdpD; Provisional; Region: PRK10490 741091010127 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 741091010128 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 741091010129 Ligand Binding Site [chemical binding]; other site 741091010130 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 741091010131 GAF domain; Region: GAF_3; pfam13492 741091010132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091010133 dimer interface [polypeptide binding]; other site 741091010134 phosphorylation site [posttranslational modification] 741091010135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091010136 ATP binding site [chemical binding]; other site 741091010137 Mg2+ binding site [ion binding]; other site 741091010138 G-X-G motif; other site 741091010139 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 741091010140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091010141 active site 741091010142 phosphorylation site [posttranslational modification] 741091010143 intermolecular recognition site; other site 741091010144 dimerization interface [polypeptide binding]; other site 741091010145 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091010146 DNA binding site [nucleotide binding] 741091010147 Predicted transcriptional regulators [Transcription]; Region: COG1695 741091010148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 741091010149 phosphoglucomutase; Validated; Region: PRK07564 741091010150 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 741091010151 active site 741091010152 substrate binding site [chemical binding]; other site 741091010153 metal binding site [ion binding]; metal-binding site 741091010154 replication initiation regulator SeqA; Provisional; Region: PRK11187 741091010155 acyl-CoA esterase; Provisional; Region: PRK10673 741091010156 PGAP1-like protein; Region: PGAP1; pfam07819 741091010157 LexA regulated protein; Provisional; Region: PRK11675 741091010158 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 741091010159 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 741091010160 dimer interface [polypeptide binding]; other site 741091010161 ligand binding site [chemical binding]; other site 741091010162 HAMP domain; Region: HAMP; pfam00672 741091010163 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091010164 dimer interface [polypeptide binding]; other site 741091010165 putative CheW interface [polypeptide binding]; other site 741091010166 flavodoxin FldA; Validated; Region: PRK09267 741091010167 ferric uptake regulator; Provisional; Region: fur; PRK09462 741091010168 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 741091010169 metal binding site 2 [ion binding]; metal-binding site 741091010170 putative DNA binding helix; other site 741091010171 metal binding site 1 [ion binding]; metal-binding site 741091010172 dimer interface [polypeptide binding]; other site 741091010173 structural Zn2+ binding site [ion binding]; other site 741091010174 YbfN-like lipoprotein; Region: YbfN; pfam13982 741091010175 outer membrane porin, OprD family; Region: OprD; pfam03573 741091010176 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 741091010177 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 741091010178 active site 741091010179 HIGH motif; other site 741091010180 nucleotide binding site [chemical binding]; other site 741091010181 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 741091010182 KMSKS motif; other site 741091010183 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 741091010184 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 741091010185 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741091010186 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741091010187 active site turn [active] 741091010188 phosphorylation site [posttranslational modification] 741091010189 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 741091010190 HPr interaction site; other site 741091010191 glycerol kinase (GK) interaction site [polypeptide binding]; other site 741091010192 active site 741091010193 phosphorylation site [posttranslational modification] 741091010194 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 741091010195 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 741091010196 active site 741091010197 trimer interface [polypeptide binding]; other site 741091010198 allosteric site; other site 741091010199 active site lid [active] 741091010200 hexamer (dimer of trimers) interface [polypeptide binding]; other site 741091010201 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 741091010202 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 741091010203 active site 741091010204 dimer interface [polypeptide binding]; other site 741091010205 MarR family; Region: MarR; pfam01047 741091010206 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 741091010207 ROK family; Region: ROK; pfam00480 741091010208 UMP phosphatase; Provisional; Region: PRK10444 741091010209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091010210 active site 741091010211 motif I; other site 741091010212 motif II; other site 741091010213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091010214 asparagine synthetase B; Provisional; Region: asnB; PRK09431 741091010215 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 741091010216 active site 741091010217 dimer interface [polypeptide binding]; other site 741091010218 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 741091010219 Ligand Binding Site [chemical binding]; other site 741091010220 Molecular Tunnel; other site 741091010221 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 741091010222 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 741091010223 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 741091010224 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 741091010225 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091010226 FeS/SAM binding site; other site 741091010227 TRAM domain; Region: TRAM; pfam01938 741091010228 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 741091010229 PhoH-like protein; Region: PhoH; pfam02562 741091010230 metal-binding heat shock protein; Provisional; Region: PRK00016 741091010231 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 741091010232 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 741091010233 Transporter associated domain; Region: CorC_HlyC; smart01091 741091010234 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 741091010235 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 741091010236 putative active site [active] 741091010237 catalytic triad [active] 741091010238 putative dimer interface [polypeptide binding]; other site 741091010239 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 741091010240 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091010241 substrate binding pocket [chemical binding]; other site 741091010242 membrane-bound complex binding site; other site 741091010243 hinge residues; other site 741091010244 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741091010245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091010246 dimer interface [polypeptide binding]; other site 741091010247 conserved gate region; other site 741091010248 putative PBP binding loops; other site 741091010249 ABC-ATPase subunit interface; other site 741091010250 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741091010251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091010252 dimer interface [polypeptide binding]; other site 741091010253 conserved gate region; other site 741091010254 putative PBP binding loops; other site 741091010255 ABC-ATPase subunit interface; other site 741091010256 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741091010257 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091010258 Walker A/P-loop; other site 741091010259 ATP binding site [chemical binding]; other site 741091010260 Q-loop/lid; other site 741091010261 ABC transporter signature motif; other site 741091010262 Walker B; other site 741091010263 D-loop; other site 741091010264 H-loop/switch region; other site 741091010265 hypothetical protein; Provisional; Region: PRK11032 741091010266 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 741091010267 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 741091010268 HIGH motif; other site 741091010269 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 741091010270 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 741091010271 active site 741091010272 KMSKS motif; other site 741091010273 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 741091010274 tRNA binding surface [nucleotide binding]; other site 741091010275 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 741091010276 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 741091010277 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 741091010278 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 741091010279 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 741091010280 active site 741091010281 (T/H)XGH motif; other site 741091010282 ribosome-associated protein; Provisional; Region: PRK11538 741091010283 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 741091010284 penicillin-binding protein 2; Provisional; Region: PRK10795 741091010285 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 741091010286 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 741091010287 cell wall shape-determining protein; Provisional; Region: PRK10794 741091010288 rare lipoprotein A; Provisional; Region: PRK10672 741091010289 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 741091010290 Sporulation related domain; Region: SPOR; pfam05036 741091010291 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 741091010292 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 741091010293 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 741091010294 hypothetical protein; Provisional; Region: PRK04998 741091010295 lipoate-protein ligase B; Provisional; Region: PRK14342 741091010296 lipoyl synthase; Provisional; Region: PRK05481 741091010297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091010298 FeS/SAM binding site; other site 741091010299 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 741091010300 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741091010301 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091010302 Walker A/P-loop; other site 741091010303 ATP binding site [chemical binding]; other site 741091010304 Q-loop/lid; other site 741091010305 ABC transporter signature motif; other site 741091010306 Walker B; other site 741091010307 D-loop; other site 741091010308 H-loop/switch region; other site 741091010309 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741091010310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091010311 dimer interface [polypeptide binding]; other site 741091010312 conserved gate region; other site 741091010313 putative PBP binding loops; other site 741091010314 ABC-ATPase subunit interface; other site 741091010315 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 741091010316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091010317 substrate binding pocket [chemical binding]; other site 741091010318 membrane-bound complex binding site; other site 741091010319 hinge residues; other site 741091010320 Predicted amidohydrolase [General function prediction only]; Region: COG0388 741091010321 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 741091010322 putative active site [active] 741091010323 catalytic triad [active] 741091010324 putative dimer interface [polypeptide binding]; other site 741091010325 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 741091010326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091010327 DNA-binding site [nucleotide binding]; DNA binding site 741091010328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091010329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091010330 homodimer interface [polypeptide binding]; other site 741091010331 catalytic residue [active] 741091010332 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 741091010333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091010334 Coenzyme A binding pocket [chemical binding]; other site 741091010335 chromosome condensation membrane protein; Provisional; Region: PRK14196 741091010336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091010337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091010338 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 741091010339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091010340 putative substrate translocation pore; other site 741091010341 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741091010342 DNA-binding site [nucleotide binding]; DNA binding site 741091010343 RNA-binding motif; other site 741091010344 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 741091010345 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 741091010346 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 741091010347 intersubunit interface [polypeptide binding]; other site 741091010348 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 741091010349 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741091010350 exopolyphosphatase; Region: exo_poly_only; TIGR03706 741091010351 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 741091010352 anti-adapter protein IraM; Provisional; Region: PRK09919 741091010353 Cupin domain; Region: Cupin_2; cl17218 741091010354 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 741091010355 MASE2 domain; Region: MASE2; pfam05230 741091010356 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091010357 metal binding site [ion binding]; metal-binding site 741091010358 active site 741091010359 I-site; other site 741091010360 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 741091010361 maltose O-acetyltransferase; Provisional; Region: PRK10092 741091010362 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 741091010363 active site 741091010364 substrate binding site [chemical binding]; other site 741091010365 trimer interface [polypeptide binding]; other site 741091010366 CoA binding site [chemical binding]; other site 741091010367 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 741091010368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091010369 putative substrate translocation pore; other site 741091010370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091010371 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 741091010372 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 741091010373 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 741091010374 haemagglutination activity domain; Region: Haemagg_act; pfam05860 741091010375 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 741091010376 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 741091010377 Surface antigen; Region: Bac_surface_Ag; pfam01103 741091010378 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 741091010379 active site 741091010380 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 741091010381 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 741091010382 tetramer (dimer of dimers) interface [polypeptide binding]; other site 741091010383 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 741091010384 NAD binding site [chemical binding]; other site 741091010385 dimer interface [polypeptide binding]; other site 741091010386 substrate binding site [chemical binding]; other site 741091010387 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 741091010388 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 741091010389 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 741091010390 homodimer interface [polypeptide binding]; other site 741091010391 NADP binding site [chemical binding]; other site 741091010392 substrate binding site [chemical binding]; other site 741091010393 S4 domain; Region: S4_2; cl17325 741091010394 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 741091010395 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 741091010396 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 741091010397 dimer interface [polypeptide binding]; other site 741091010398 ADP-ribose binding site [chemical binding]; other site 741091010399 active site 741091010400 nudix motif; other site 741091010401 metal binding site [ion binding]; metal-binding site 741091010402 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 741091010403 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 741091010404 Protein export membrane protein; Region: SecD_SecF; cl14618 741091010405 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 741091010406 ArsC family; Region: ArsC; pfam03960 741091010407 putative catalytic residues [active] 741091010408 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 741091010409 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 741091010410 metal binding site [ion binding]; metal-binding site 741091010411 dimer interface [polypeptide binding]; other site 741091010412 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 741091010413 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 741091010414 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 741091010415 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 741091010416 ATP-grasp domain; Region: ATP-grasp_4; cl17255 741091010417 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 741091010418 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741091010419 catalytic residue [active] 741091010420 putative hydrolase; Provisional; Region: PRK11460 741091010421 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 741091010422 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 741091010423 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 741091010424 Helicase; Region: Helicase_RecD; pfam05127 741091010425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091010426 Coenzyme A binding pocket [chemical binding]; other site 741091010427 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 741091010428 Predicted membrane protein [Function unknown]; Region: COG2707 741091010429 Predicted metalloprotease [General function prediction only]; Region: COG2321 741091010430 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 741091010431 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 741091010432 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 741091010433 ATP binding site [chemical binding]; other site 741091010434 active site 741091010435 substrate binding site [chemical binding]; other site 741091010436 lipoprotein; Provisional; Region: PRK11679 741091010437 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 741091010438 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 741091010439 dihydrodipicolinate synthase; Region: dapA; TIGR00674 741091010440 dimer interface [polypeptide binding]; other site 741091010441 active site 741091010442 catalytic residue [active] 741091010443 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 741091010444 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 741091010445 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 741091010446 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 741091010447 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 741091010448 catalytic triad [active] 741091010449 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 741091010450 Domain of unknown function DUF20; Region: UPF0118; pfam01594 741091010451 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 741091010452 Peptidase family M48; Region: Peptidase_M48; pfam01435 741091010453 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 741091010454 ArsC family; Region: ArsC; pfam03960 741091010455 catalytic residues [active] 741091010456 DNA replication initiation factor; Provisional; Region: PRK08084 741091010457 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 741091010458 uracil transporter; Provisional; Region: PRK10720 741091010459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741091010460 active site 741091010461 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 741091010462 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 741091010463 dimerization interface [polypeptide binding]; other site 741091010464 putative ATP binding site [chemical binding]; other site 741091010465 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 741091010466 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 741091010467 active site 741091010468 substrate binding site [chemical binding]; other site 741091010469 cosubstrate binding site; other site 741091010470 catalytic site [active] 741091010471 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 741091010472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091010473 Coenzyme A binding pocket [chemical binding]; other site 741091010474 polyphosphate kinase; Provisional; Region: PRK05443 741091010475 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 741091010476 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 741091010477 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 741091010478 domain interface [polypeptide binding]; other site 741091010479 active site 741091010480 catalytic site [active] 741091010481 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 741091010482 domain interface [polypeptide binding]; other site 741091010483 active site 741091010484 catalytic site [active] 741091010485 exopolyphosphatase; Provisional; Region: PRK10854 741091010486 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741091010487 nucleotide binding site [chemical binding]; other site 741091010488 MASE1; Region: MASE1; cl17823 741091010489 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091010490 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 741091010491 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091010492 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 741091010493 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 741091010494 MgtE intracellular N domain; Region: MgtE_N; smart00924 741091010495 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 741091010496 Divalent cation transporter; Region: MgtE; cl00786 741091010497 MASE1; Region: MASE1; cl17823 741091010498 PAS domain S-box; Region: sensory_box; TIGR00229 741091010499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091010500 putative active site [active] 741091010501 heme pocket [chemical binding]; other site 741091010502 PAS fold; Region: PAS; pfam00989 741091010503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091010504 putative active site [active] 741091010505 heme pocket [chemical binding]; other site 741091010506 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091010507 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091010508 metal binding site [ion binding]; metal-binding site 741091010509 active site 741091010510 I-site; other site 741091010511 AlkA N-terminal domain; Region: AlkA_N; pfam06029 741091010512 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 741091010513 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 741091010514 minor groove reading motif; other site 741091010515 helix-hairpin-helix signature motif; other site 741091010516 substrate binding pocket [chemical binding]; other site 741091010517 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 741091010518 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 741091010519 active site 741091010520 HIGH motif; other site 741091010521 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 741091010522 KMSKS motif; other site 741091010523 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 741091010524 tRNA binding surface [nucleotide binding]; other site 741091010525 anticodon binding site; other site 741091010526 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 741091010527 substrate binding site [chemical binding]; other site 741091010528 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 741091010529 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741091010530 putative active site [active] 741091010531 putative metal binding site [ion binding]; other site 741091010532 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 741091010533 active site 741091010534 dinuclear metal binding site [ion binding]; other site 741091010535 dimerization interface [polypeptide binding]; other site 741091010536 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 741091010537 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 741091010538 ATP-grasp domain; Region: ATP-grasp; pfam02222 741091010539 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 741091010540 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 741091010541 FtsX-like permease family; Region: FtsX; pfam02687 741091010542 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 741091010543 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 741091010544 Walker A/P-loop; other site 741091010545 ATP binding site [chemical binding]; other site 741091010546 Q-loop/lid; other site 741091010547 ABC transporter signature motif; other site 741091010548 Walker B; other site 741091010549 D-loop; other site 741091010550 H-loop/switch region; other site 741091010551 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 741091010552 active site 741091010553 catalytic triad [active] 741091010554 oxyanion hole [active] 741091010555 switch loop; other site 741091010556 oxidoreductase; Provisional; Region: PRK08017 741091010557 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 741091010558 NADP binding site [chemical binding]; other site 741091010559 active site 741091010560 steroid binding site; other site 741091010561 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 741091010562 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 741091010563 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 741091010564 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 741091010565 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 741091010566 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 741091010567 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 741091010568 DNA binding residues [nucleotide binding] 741091010569 dimer interface [polypeptide binding]; other site 741091010570 copper binding site [ion binding]; other site 741091010571 copper exporting ATPase; Provisional; Region: copA; PRK10671 741091010572 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 741091010573 metal-binding site [ion binding] 741091010574 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 741091010575 metal-binding site [ion binding] 741091010576 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 741091010577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091010578 motif II; other site 741091010579 TraB family; Region: TraB; cl12050 741091010580 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 741091010581 putative deacylase active site [active] 741091010582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091010583 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741091010584 putative substrate translocation pore; other site 741091010585 putative cation:proton antiport protein; Provisional; Region: PRK10669 741091010586 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 741091010587 TrkA-N domain; Region: TrkA_N; pfam02254 741091010588 inosine/guanosine kinase; Provisional; Region: PRK15074 741091010589 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741091010590 substrate binding site [chemical binding]; other site 741091010591 ATP binding site [chemical binding]; other site 741091010592 ferrochelatase; Reviewed; Region: hemH; PRK00035 741091010593 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 741091010594 C-terminal domain interface [polypeptide binding]; other site 741091010595 active site 741091010596 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 741091010597 active site 741091010598 N-terminal domain interface [polypeptide binding]; other site 741091010599 adenylate kinase; Reviewed; Region: adk; PRK00279 741091010600 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 741091010601 AMP-binding site [chemical binding]; other site 741091010602 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 741091010603 heat shock protein 90; Provisional; Region: PRK05218 741091010604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091010605 ATP binding site [chemical binding]; other site 741091010606 Mg2+ binding site [ion binding]; other site 741091010607 G-X-G motif; other site 741091010608 recombination protein RecR; Reviewed; Region: recR; PRK00076 741091010609 RecR protein; Region: RecR; pfam02132 741091010610 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 741091010611 putative active site [active] 741091010612 putative metal-binding site [ion binding]; other site 741091010613 tetramer interface [polypeptide binding]; other site 741091010614 hypothetical protein; Validated; Region: PRK00153 741091010615 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961 741091010616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091010617 Walker A motif; other site 741091010618 ATP binding site [chemical binding]; other site 741091010619 Walker B motif; other site 741091010620 arginine finger; other site 741091010621 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 741091010622 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 741091010623 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 741091010624 alpha-amylase; Reviewed; Region: malS; PRK09505 741091010625 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 741091010626 active site 741091010627 catalytic site [active] 741091010628 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741091010629 active site 741091010630 hypothetical protein; Provisional; Region: PRK10527 741091010631 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 741091010632 hypothetical protein; Provisional; Region: PRK11038 741091010633 hypothetical protein; Provisional; Region: PRK11281 741091010634 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 741091010635 Mechanosensitive ion channel; Region: MS_channel; pfam00924 741091010636 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 741091010637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091010638 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 741091010639 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 741091010640 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091010641 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091010642 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 741091010643 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 741091010644 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 741091010645 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 741091010646 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 741091010647 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 741091010648 metal binding site [ion binding]; metal-binding site 741091010649 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 741091010650 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741091010651 ABC-ATPase subunit interface; other site 741091010652 dimer interface [polypeptide binding]; other site 741091010653 putative PBP binding regions; other site 741091010654 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 741091010655 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 741091010656 Hha toxicity attenuator; Provisional; Region: PRK10667 741091010657 gene expression modulator; Provisional; Region: PRK10945 741091010658 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091010659 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091010660 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 741091010661 dimerization interface [polypeptide binding]; other site 741091010662 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 741091010663 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 741091010664 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 741091010665 active site 741091010666 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 741091010667 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 741091010668 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 741091010669 DNA binding site [nucleotide binding] 741091010670 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 741091010671 active site 741091010672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 741091010673 acyl-CoA thioesterase II; Provisional; Region: PRK10526 741091010674 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 741091010675 active site 741091010676 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 741091010677 catalytic triad [active] 741091010678 dimer interface [polypeptide binding]; other site 741091010679 ammonium transporter; Provisional; Region: PRK10666 741091010680 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 741091010681 Nitrogen regulatory protein P-II; Region: P-II; smart00938 741091010682 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 741091010683 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741091010684 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 741091010685 Walker A/P-loop; other site 741091010686 ATP binding site [chemical binding]; other site 741091010687 Q-loop/lid; other site 741091010688 ABC transporter signature motif; other site 741091010689 Walker B; other site 741091010690 D-loop; other site 741091010691 H-loop/switch region; other site 741091010692 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 741091010693 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741091010694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091010695 Walker A/P-loop; other site 741091010696 ATP binding site [chemical binding]; other site 741091010697 Q-loop/lid; other site 741091010698 ABC transporter signature motif; other site 741091010699 Walker B; other site 741091010700 D-loop; other site 741091010701 H-loop/switch region; other site 741091010702 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 741091010703 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091010704 putative DNA binding site [nucleotide binding]; other site 741091010705 putative Zn2+ binding site [ion binding]; other site 741091010706 AsnC family; Region: AsnC_trans_reg; pfam01037 741091010707 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 741091010708 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 741091010709 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741091010710 catalytic residue [active] 741091010711 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 741091010712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091010713 active site 741091010714 motif I; other site 741091010715 motif II; other site 741091010716 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 741091010717 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 741091010718 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 741091010719 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 741091010720 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 741091010721 Ligand Binding Site [chemical binding]; other site 741091010722 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 741091010723 active site 741091010724 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 741091010725 periplasmic folding chaperone; Provisional; Region: PRK10788 741091010726 SurA N-terminal domain; Region: SurA_N_3; cl07813 741091010727 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 741091010728 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 741091010729 IHF dimer interface [polypeptide binding]; other site 741091010730 IHF - DNA interface [nucleotide binding]; other site 741091010731 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 741091010732 Found in ATP-dependent protease La (LON); Region: LON; smart00464 741091010733 Found in ATP-dependent protease La (LON); Region: LON; smart00464 741091010734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091010735 Walker A motif; other site 741091010736 ATP binding site [chemical binding]; other site 741091010737 Walker B motif; other site 741091010738 arginine finger; other site 741091010739 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 741091010740 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 741091010741 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 741091010742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091010743 Walker A motif; other site 741091010744 ATP binding site [chemical binding]; other site 741091010745 Walker B motif; other site 741091010746 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 741091010747 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 741091010748 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 741091010749 oligomer interface [polypeptide binding]; other site 741091010750 active site residues [active] 741091010751 trigger factor; Provisional; Region: tig; PRK01490 741091010752 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 741091010753 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 741091010754 transcriptional regulator BolA; Provisional; Region: PRK11628 741091010755 hypothetical protein; Provisional; Region: PRK11627 741091010756 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 741091010757 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 741091010758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091010759 putative substrate translocation pore; other site 741091010760 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 741091010761 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 741091010762 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 741091010763 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 741091010764 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 741091010765 D-pathway; other site 741091010766 Putative ubiquinol binding site [chemical binding]; other site 741091010767 Low-spin heme (heme b) binding site [chemical binding]; other site 741091010768 Putative water exit pathway; other site 741091010769 Binuclear center (heme o3/CuB) [ion binding]; other site 741091010770 K-pathway; other site 741091010771 Putative proton exit pathway; other site 741091010772 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 741091010773 Subunit I/III interface [polypeptide binding]; other site 741091010774 Subunit III/IV interface [polypeptide binding]; other site 741091010775 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 741091010776 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 741091010777 UbiA prenyltransferase family; Region: UbiA; pfam01040 741091010778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091010779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741091010780 putative substrate translocation pore; other site 741091010781 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 741091010782 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741091010783 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 741091010784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 741091010785 Transposase; Region: DEDD_Tnp_IS110; pfam01548 741091010786 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 741091010787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 741091010788 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 741091010789 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 741091010790 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 741091010791 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 741091010792 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 741091010793 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 741091010794 conserved cys residue [active] 741091010795 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 741091010796 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 741091010797 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 741091010798 Ligand Binding Site [chemical binding]; other site 741091010799 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 741091010800 active site residue [active] 741091010801 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 741091010802 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 741091010803 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 741091010804 substrate binding pocket [chemical binding]; other site 741091010805 chain length determination region; other site 741091010806 substrate-Mg2+ binding site; other site 741091010807 catalytic residues [active] 741091010808 aspartate-rich region 1; other site 741091010809 active site lid residues [active] 741091010810 aspartate-rich region 2; other site 741091010811 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 741091010812 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 741091010813 TPP-binding site; other site 741091010814 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 741091010815 PYR/PP interface [polypeptide binding]; other site 741091010816 dimer interface [polypeptide binding]; other site 741091010817 TPP binding site [chemical binding]; other site 741091010818 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 741091010819 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091010820 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091010821 active site 741091010822 catalytic tetrad [active] 741091010823 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 741091010824 tetramer interfaces [polypeptide binding]; other site 741091010825 binuclear metal-binding site [ion binding]; other site 741091010826 thiamine monophosphate kinase; Provisional; Region: PRK05731 741091010827 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 741091010828 ATP binding site [chemical binding]; other site 741091010829 dimerization interface [polypeptide binding]; other site 741091010830 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 741091010831 putative RNA binding site [nucleotide binding]; other site 741091010832 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 741091010833 homopentamer interface [polypeptide binding]; other site 741091010834 active site 741091010835 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 741091010836 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 741091010837 catalytic motif [active] 741091010838 Zn binding site [ion binding]; other site 741091010839 RibD C-terminal domain; Region: RibD_C; cl17279 741091010840 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 741091010841 ATP cone domain; Region: ATP-cone; pfam03477 741091010842 hypothetical protein; Provisional; Region: PRK11530 741091010843 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 741091010844 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 741091010845 Protein export membrane protein; Region: SecD_SecF; pfam02355 741091010846 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 741091010847 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 741091010848 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 741091010849 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 741091010850 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 741091010851 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 741091010852 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 741091010853 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 741091010854 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 741091010855 Protein of unknown function, DUF479; Region: DUF479; cl01203 741091010856 peroxidase; Provisional; Region: PRK15000 741091010857 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 741091010858 dimer interface [polypeptide binding]; other site 741091010859 decamer (pentamer of dimers) interface [polypeptide binding]; other site 741091010860 catalytic triad [active] 741091010861 peroxidatic and resolving cysteines [active] 741091010862 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 741091010863 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 741091010864 putative proline-specific permease; Provisional; Region: proY; PRK10580 741091010865 Spore germination protein; Region: Spore_permease; cl17796 741091010866 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 741091010867 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 741091010868 substrate binding site [chemical binding]; other site 741091010869 THF binding site; other site 741091010870 zinc-binding site [ion binding]; other site 741091010871 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 741091010872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091010873 non-specific DNA binding site [nucleotide binding]; other site 741091010874 salt bridge; other site 741091010875 sequence-specific DNA binding site [nucleotide binding]; other site 741091010876 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 741091010877 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 741091010878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091010879 putative active site [active] 741091010880 heme pocket [chemical binding]; other site 741091010881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091010882 dimer interface [polypeptide binding]; other site 741091010883 phosphorylation site [posttranslational modification] 741091010884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091010885 ATP binding site [chemical binding]; other site 741091010886 Mg2+ binding site [ion binding]; other site 741091010887 G-X-G motif; other site 741091010888 transcriptional regulator PhoB; Provisional; Region: PRK10161 741091010889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091010890 active site 741091010891 phosphorylation site [posttranslational modification] 741091010892 intermolecular recognition site; other site 741091010893 dimerization interface [polypeptide binding]; other site 741091010894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091010895 DNA binding site [nucleotide binding] 741091010896 exonuclease subunit SbcD; Provisional; Region: PRK10966 741091010897 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 741091010898 active site 741091010899 metal binding site [ion binding]; metal-binding site 741091010900 DNA binding site [nucleotide binding] 741091010901 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 741091010902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091010903 AAA domain; Region: AAA_23; pfam13476 741091010904 Walker A/P-loop; other site 741091010905 ATP binding site [chemical binding]; other site 741091010906 Q-loop/lid; other site 741091010907 exonuclease subunit SbcC; Provisional; Region: PRK10246 741091010908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091010909 ABC transporter signature motif; other site 741091010910 Walker B; other site 741091010911 D-loop; other site 741091010912 H-loop/switch region; other site 741091010913 HNH endonuclease; Region: HNH_2; pfam13391 741091010914 fructokinase; Reviewed; Region: PRK09557 741091010915 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741091010916 nucleotide binding site [chemical binding]; other site 741091010917 recombination associated protein; Reviewed; Region: rdgC; PRK00321 741091010918 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 741091010919 hypothetical protein; Provisional; Region: PRK10481 741091010920 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 741091010921 OPT oligopeptide transporter protein; Region: OPT; cl14607 741091010922 OPT oligopeptide transporter protein; Region: OPT; cl14607 741091010923 Transcriptional regulator [Transcription]; Region: IclR; COG1414 741091010924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091010925 putative DNA binding site [nucleotide binding]; other site 741091010926 putative Zn2+ binding site [ion binding]; other site 741091010927 Bacterial transcriptional regulator; Region: IclR; pfam01614 741091010928 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 741091010929 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 741091010930 ADP binding site [chemical binding]; other site 741091010931 magnesium binding site [ion binding]; other site 741091010932 putative shikimate binding site; other site 741091010933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 741091010934 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741091010935 Protein of unknown function (DUF808); Region: DUF808; pfam05661 741091010936 Methyltransferase domain; Region: Methyltransf_31; pfam13847 741091010937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091010938 S-adenosylmethionine binding site [chemical binding]; other site 741091010939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091010940 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 741091010941 salt bridge; other site 741091010942 non-specific DNA binding site [nucleotide binding]; other site 741091010943 sequence-specific DNA binding site [nucleotide binding]; other site 741091010944 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 741091010945 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741091010946 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 741091010947 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 741091010948 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 741091010949 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 741091010950 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 741091010951 active site residue [active] 741091010952 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 741091010953 active site residue [active] 741091010954 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 741091010955 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 741091010956 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 741091010957 putative di-iron ligands [ion binding]; other site 741091010958 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 741091010959 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 741091010960 catalytic core [active] 741091010961 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 741091010962 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 741091010963 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 741091010964 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 741091010965 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 741091010966 dimerization interface [polypeptide binding]; other site 741091010967 ATP binding site [chemical binding]; other site 741091010968 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 741091010969 dimerization interface [polypeptide binding]; other site 741091010970 ATP binding site [chemical binding]; other site 741091010971 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 741091010972 putative active site [active] 741091010973 catalytic triad [active] 741091010974 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 741091010975 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091010976 substrate binding pocket [chemical binding]; other site 741091010977 membrane-bound complex binding site; other site 741091010978 hinge residues; other site 741091010979 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741091010980 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741091010981 catalytic residue [active] 741091010982 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 741091010983 nucleoside/Zn binding site; other site 741091010984 dimer interface [polypeptide binding]; other site 741091010985 catalytic motif [active] 741091010986 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 741091010987 hypothetical protein; Provisional; Region: PRK11590 741091010988 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 741091010989 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741091010990 active site turn [active] 741091010991 phosphorylation site [posttranslational modification] 741091010992 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741091010993 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 741091010994 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 741091010995 putative active site [active] 741091010996 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 741091010997 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741091010998 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 741091010999 putative active site [active] 741091011000 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 741091011001 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 741091011002 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 741091011003 active site 741091011004 hydrophilic channel; other site 741091011005 dimerization interface [polypeptide binding]; other site 741091011006 catalytic residues [active] 741091011007 active site lid [active] 741091011008 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 741091011009 Recombination protein O N terminal; Region: RecO_N; pfam11967 741091011010 Recombination protein O C terminal; Region: RecO_C; pfam02565 741091011011 GTPase Era; Reviewed; Region: era; PRK00089 741091011012 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 741091011013 G1 box; other site 741091011014 GTP/Mg2+ binding site [chemical binding]; other site 741091011015 Switch I region; other site 741091011016 G2 box; other site 741091011017 Switch II region; other site 741091011018 G3 box; other site 741091011019 G4 box; other site 741091011020 G5 box; other site 741091011021 KH domain; Region: KH_2; pfam07650 741091011022 ribonuclease III; Reviewed; Region: rnc; PRK00102 741091011023 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 741091011024 dimerization interface [polypeptide binding]; other site 741091011025 active site 741091011026 metal binding site [ion binding]; metal-binding site 741091011027 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 741091011028 dsRNA binding site [nucleotide binding]; other site 741091011029 signal peptidase I; Provisional; Region: PRK10861 741091011030 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 741091011031 Catalytic site [active] 741091011032 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 741091011033 GTP-binding protein LepA; Provisional; Region: PRK05433 741091011034 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 741091011035 G1 box; other site 741091011036 putative GEF interaction site [polypeptide binding]; other site 741091011037 GTP/Mg2+ binding site [chemical binding]; other site 741091011038 Switch I region; other site 741091011039 G2 box; other site 741091011040 G3 box; other site 741091011041 Switch II region; other site 741091011042 G4 box; other site 741091011043 G5 box; other site 741091011044 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 741091011045 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 741091011046 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 741091011047 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 741091011048 anti-sigma E factor; Provisional; Region: rseB; PRK09455 741091011049 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 741091011050 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 741091011051 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 741091011052 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 741091011053 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 741091011054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 741091011055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741091011056 DNA binding residues [nucleotide binding] 741091011057 L-aspartate oxidase; Provisional; Region: PRK09077 741091011058 L-aspartate oxidase; Provisional; Region: PRK06175 741091011059 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 741091011060 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 741091011061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091011062 S-adenosylmethionine binding site [chemical binding]; other site 741091011063 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 741091011064 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 741091011065 ATP binding site [chemical binding]; other site 741091011066 Mg++ binding site [ion binding]; other site 741091011067 motif III; other site 741091011068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091011069 nucleotide binding region [chemical binding]; other site 741091011070 ATP-binding site [chemical binding]; other site 741091011071 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 741091011072 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 741091011073 ligand binding site [chemical binding]; other site 741091011074 active site 741091011075 UGI interface [polypeptide binding]; other site 741091011076 catalytic site [active] 741091011077 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 741091011078 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 741091011079 dimer interface [polypeptide binding]; other site 741091011080 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 741091011081 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 741091011082 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 741091011083 recombination and repair protein; Provisional; Region: PRK10869 741091011084 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 741091011085 Walker A/P-loop; other site 741091011086 ATP binding site [chemical binding]; other site 741091011087 Q-loop/lid; other site 741091011088 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 741091011089 Q-loop/lid; other site 741091011090 ABC transporter signature motif; other site 741091011091 Walker B; other site 741091011092 D-loop; other site 741091011093 H-loop/switch region; other site 741091011094 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 741091011095 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 741091011096 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 741091011097 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741091011098 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 741091011099 hypothetical protein; Validated; Region: PRK01777 741091011100 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 741091011101 putative coenzyme Q binding site [chemical binding]; other site 741091011102 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 741091011103 SmpB-tmRNA interface; other site 741091011104 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091011105 dimerization interface [polypeptide binding]; other site 741091011106 Transcriptional regulators [Transcription]; Region: MarR; COG1846 741091011107 putative DNA binding site [nucleotide binding]; other site 741091011108 putative Zn2+ binding site [ion binding]; other site 741091011109 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 741091011110 active site residue [active] 741091011111 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 741091011112 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 741091011113 aromatic chitin/cellulose binding site residues [chemical binding]; other site 741091011114 Glyco_18 domain; Region: Glyco_18; smart00636 741091011115 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 741091011116 active site 741091011117 Beta/Gamma crystallin; Region: Crystall; cl02528 741091011118 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 741091011119 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091011120 substrate binding pocket [chemical binding]; other site 741091011121 membrane-bound complex binding site; other site 741091011122 hinge residues; other site 741091011123 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 741091011124 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 741091011125 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741091011126 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 741091011127 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741091011128 active site 741091011129 phosphorylation site [posttranslational modification] 741091011130 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 741091011131 active site 741091011132 P-loop; other site 741091011133 phosphorylation site [posttranslational modification] 741091011134 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 741091011135 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 741091011136 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 741091011137 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 741091011138 putative NAD(P) binding site [chemical binding]; other site 741091011139 catalytic Zn binding site [ion binding]; other site 741091011140 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 741091011141 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 741091011142 intersubunit interface [polypeptide binding]; other site 741091011143 active site 741091011144 zinc binding site [ion binding]; other site 741091011145 Na+ binding site [ion binding]; other site 741091011146 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 741091011147 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 741091011148 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 741091011149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091011150 Coenzyme A binding pocket [chemical binding]; other site 741091011151 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 741091011152 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 741091011153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091011154 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 741091011155 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 741091011156 DNA binding site [nucleotide binding] 741091011157 active site 741091011158 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 741091011159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091011160 Coenzyme A binding pocket [chemical binding]; other site 741091011161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 741091011162 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 741091011163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091011164 non-specific DNA binding site [nucleotide binding]; other site 741091011165 salt bridge; other site 741091011166 sequence-specific DNA binding site [nucleotide binding]; other site 741091011167 Cupin domain; Region: Cupin_2; pfam07883 741091011168 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 741091011169 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 741091011170 PA/protease or protease-like domain interface [polypeptide binding]; other site 741091011171 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 741091011172 Peptidase family M28; Region: Peptidase_M28; pfam04389 741091011173 metal binding site [ion binding]; metal-binding site 741091011174 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 741091011175 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091011176 substrate binding pocket [chemical binding]; other site 741091011177 membrane-bound complex binding site; other site 741091011178 hinge residues; other site 741091011179 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 741091011180 amidohydrolase; Region: amidohydrolases; TIGR01891 741091011181 metal binding site [ion binding]; metal-binding site 741091011182 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091011183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091011184 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 741091011185 dimerization interface [polypeptide binding]; other site 741091011186 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 741091011187 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 741091011188 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 741091011189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741091011190 hemolysin; Provisional; Region: PRK15087 741091011191 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 741091011192 HD domain; Region: HD_3; pfam13023 741091011193 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 741091011194 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 741091011195 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 741091011196 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 741091011197 Walker A/P-loop; other site 741091011198 ATP binding site [chemical binding]; other site 741091011199 Q-loop/lid; other site 741091011200 ABC transporter signature motif; other site 741091011201 Walker B; other site 741091011202 D-loop; other site 741091011203 H-loop/switch region; other site 741091011204 TOBE domain; Region: TOBE_2; pfam08402 741091011205 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 741091011206 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741091011207 active site 741091011208 metal binding site [ion binding]; metal-binding site 741091011209 hexamer interface [polypeptide binding]; other site 741091011210 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741091011211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091011212 dimer interface [polypeptide binding]; other site 741091011213 conserved gate region; other site 741091011214 putative PBP binding loops; other site 741091011215 ABC-ATPase subunit interface; other site 741091011216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091011217 dimer interface [polypeptide binding]; other site 741091011218 conserved gate region; other site 741091011219 putative PBP binding loops; other site 741091011220 ABC-ATPase subunit interface; other site 741091011221 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741091011222 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 741091011223 substrate binding site [chemical binding]; other site 741091011224 dimer interface [polypeptide binding]; other site 741091011225 ATP binding site [chemical binding]; other site 741091011226 D-allose kinase; Provisional; Region: PRK09698 741091011227 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741091011228 nucleotide binding site [chemical binding]; other site 741091011229 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 741091011230 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 741091011231 substrate binding site [chemical binding]; other site 741091011232 hexamer interface [polypeptide binding]; other site 741091011233 metal binding site [ion binding]; metal-binding site 741091011234 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091011235 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091011236 TM-ABC transporter signature motif; other site 741091011237 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091011238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091011239 TM-ABC transporter signature motif; other site 741091011240 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 741091011241 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741091011242 Walker A/P-loop; other site 741091011243 ATP binding site [chemical binding]; other site 741091011244 Q-loop/lid; other site 741091011245 ABC transporter signature motif; other site 741091011246 Walker B; other site 741091011247 D-loop; other site 741091011248 H-loop/switch region; other site 741091011249 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741091011250 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 741091011251 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 741091011252 ligand binding site [chemical binding]; other site 741091011253 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 741091011254 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 741091011255 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741091011256 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 741091011257 classical (c) SDRs; Region: SDR_c; cd05233 741091011258 NAD(P) binding site [chemical binding]; other site 741091011259 active site 741091011260 glycine dehydrogenase; Provisional; Region: PRK05367 741091011261 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 741091011262 tetramer interface [polypeptide binding]; other site 741091011263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091011264 catalytic residue [active] 741091011265 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 741091011266 tetramer interface [polypeptide binding]; other site 741091011267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091011268 catalytic residue [active] 741091011269 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 741091011270 lipoyl attachment site [posttranslational modification]; other site 741091011271 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 741091011272 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 741091011273 oxidoreductase; Provisional; Region: PRK08013 741091011274 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 741091011275 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 741091011276 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 741091011277 proline aminopeptidase P II; Provisional; Region: PRK10879 741091011278 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 741091011279 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 741091011280 active site 741091011281 hypothetical protein; Reviewed; Region: PRK01736 741091011282 Z-ring-associated protein; Provisional; Region: PRK10972 741091011283 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 741091011284 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 741091011285 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 741091011286 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 741091011287 ligand binding site [chemical binding]; other site 741091011288 NAD binding site [chemical binding]; other site 741091011289 tetramer interface [polypeptide binding]; other site 741091011290 catalytic site [active] 741091011291 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 741091011292 L-serine binding site [chemical binding]; other site 741091011293 ACT domain interface; other site 741091011294 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 741091011295 tetramer (dimer of dimers) interface [polypeptide binding]; other site 741091011296 active site 741091011297 dimer interface [polypeptide binding]; other site 741091011298 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 741091011299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091011300 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 741091011301 putative dimerization interface [polypeptide binding]; other site 741091011302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091011303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091011304 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 741091011305 putative effector binding pocket; other site 741091011306 putative dimerization interface [polypeptide binding]; other site 741091011307 short chain dehydrogenase; Provisional; Region: PRK06482 741091011308 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 741091011309 NADP binding site [chemical binding]; other site 741091011310 active site 741091011311 steroid binding site; other site 741091011312 Uncharacterized conserved protein [Function unknown]; Region: COG2968 741091011313 oxidative stress defense protein; Provisional; Region: PRK11087 741091011314 arginine exporter protein; Provisional; Region: PRK09304 741091011315 mechanosensitive channel MscS; Provisional; Region: PRK10334 741091011316 Conserved TM helix; Region: TM_helix; pfam05552 741091011317 Mechanosensitive ion channel; Region: MS_channel; pfam00924 741091011318 galactoside permease; Reviewed; Region: lacY; PRK09528 741091011319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091011320 putative substrate translocation pore; other site 741091011321 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 741091011322 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 741091011323 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 741091011324 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 741091011325 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 741091011326 lac repressor; Reviewed; Region: lacI; PRK09526 741091011327 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091011328 DNA binding site [nucleotide binding] 741091011329 domain linker motif; other site 741091011330 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 741091011331 ligand binding site [chemical binding]; other site 741091011332 dimerization interface (open form) [polypeptide binding]; other site 741091011333 dimerization interface (closed form) [polypeptide binding]; other site 741091011334 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 741091011335 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 741091011336 active site 741091011337 intersubunit interface [polypeptide binding]; other site 741091011338 zinc binding site [ion binding]; other site 741091011339 Na+ binding site [ion binding]; other site 741091011340 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 741091011341 Phosphoglycerate kinase; Region: PGK; pfam00162 741091011342 substrate binding site [chemical binding]; other site 741091011343 hinge regions; other site 741091011344 ADP binding site [chemical binding]; other site 741091011345 catalytic site [active] 741091011346 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 741091011347 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 741091011348 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 741091011349 transketolase; Reviewed; Region: PRK12753 741091011350 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 741091011351 TPP-binding site [chemical binding]; other site 741091011352 dimer interface [polypeptide binding]; other site 741091011353 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 741091011354 PYR/PP interface [polypeptide binding]; other site 741091011355 dimer interface [polypeptide binding]; other site 741091011356 TPP binding site [chemical binding]; other site 741091011357 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 741091011358 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 741091011359 Fimbrial protein; Region: Fimbrial; cl01416 741091011360 putative chaperone protein EcpD; Provisional; Region: PRK09926 741091011361 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741091011362 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741091011363 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 741091011364 PapC N-terminal domain; Region: PapC_N; pfam13954 741091011365 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741091011366 PapC C-terminal domain; Region: PapC_C; pfam13953 741091011367 Fimbrial protein; Region: Fimbrial; cl01416 741091011368 putative fimbrial protein StaE; Provisional; Region: PRK15263 741091011369 Fimbrial protein; Region: Fimbrial; cl01416 741091011370 Fimbrial protein; Region: Fimbrial; cl01416 741091011371 arginine decarboxylase; Provisional; Region: PRK05354 741091011372 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 741091011373 dimer interface [polypeptide binding]; other site 741091011374 active site 741091011375 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 741091011376 catalytic residues [active] 741091011377 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 741091011378 S-adenosylmethionine synthetase; Validated; Region: PRK05250 741091011379 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 741091011380 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 741091011381 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 741091011382 putative fimbrial protein TcfA; Provisional; Region: PRK15308 741091011383 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; cl04524 741091011384 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 741091011385 CblD like pilus biogenesis initiator; Region: CblD; cl06460 741091011386 CblD like pilus biogenesis initiator; Region: CblD; cl06460 741091011387 putative fimbrial protein TcfA; Provisional; Region: PRK15308 741091011388 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 741091011389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091011390 putative substrate translocation pore; other site 741091011391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091011392 hypothetical protein; Provisional; Region: PRK04860 741091011393 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 741091011394 DNA-specific endonuclease I; Provisional; Region: PRK15137 741091011395 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 741091011396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 741091011397 RNA methyltransferase, RsmE family; Region: TIGR00046 741091011398 glutathione synthetase; Provisional; Region: PRK05246 741091011399 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 741091011400 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 741091011401 hypothetical protein; Validated; Region: PRK00228 741091011402 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 741091011403 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 741091011404 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 741091011405 Walker A motif; other site 741091011406 ATP binding site [chemical binding]; other site 741091011407 Walker B motif; other site 741091011408 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 741091011409 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 741091011410 catalytic residue [active] 741091011411 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 741091011412 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 741091011413 YGGT family; Region: YGGT; pfam02325 741091011414 YGGT family; Region: YGGT; pfam02325 741091011415 hypothetical protein; Validated; Region: PRK05090 741091011416 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 741091011417 active site 741091011418 dimerization interface [polypeptide binding]; other site 741091011419 HemN family oxidoreductase; Provisional; Region: PRK05660 741091011420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091011421 FeS/SAM binding site; other site 741091011422 HemN C-terminal domain; Region: HemN_C; pfam06969 741091011423 hypothetical protein; Provisional; Region: PRK10626 741091011424 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 741091011425 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 741091011426 glutaminase; Provisional; Region: PRK00971 741091011427 hypothetical protein; Provisional; Region: PRK11702 741091011428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091011429 S-adenosylmethionine binding site [chemical binding]; other site 741091011430 adenine DNA glycosylase; Provisional; Region: PRK10880 741091011431 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 741091011432 minor groove reading motif; other site 741091011433 helix-hairpin-helix signature motif; other site 741091011434 substrate binding pocket [chemical binding]; other site 741091011435 active site 741091011436 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 741091011437 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 741091011438 DNA binding and oxoG recognition site [nucleotide binding] 741091011439 oxidative damage protection protein; Provisional; Region: PRK05408 741091011440 murein transglycosylase C; Provisional; Region: mltC; PRK11671 741091011441 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 741091011442 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741091011443 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741091011444 catalytic residue [active] 741091011445 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 741091011446 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 741091011447 putative ADP-binding pocket [chemical binding]; other site 741091011448 Pectate lyase; Region: Pec_lyase_C; cl01593 741091011449 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 741091011450 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 741091011451 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 741091011452 trimer interface [polypeptide binding]; other site 741091011453 active site 741091011454 substrate binding site [chemical binding]; other site 741091011455 CoA binding site [chemical binding]; other site 741091011456 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 741091011457 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 741091011458 putative ADP-binding pocket [chemical binding]; other site 741091011459 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 741091011460 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 741091011461 tyrosine kinase; Provisional; Region: PRK11519 741091011462 Chain length determinant protein; Region: Wzz; pfam02706 741091011463 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 741091011464 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 741091011465 Low molecular weight phosphatase family; Region: LMWPc; cd00115 741091011466 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 741091011467 active site 741091011468 polysaccharide export protein Wza; Provisional; Region: PRK15078 741091011469 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 741091011470 SLBB domain; Region: SLBB; pfam10531 741091011471 SLBB domain; Region: SLBB; pfam10531 741091011472 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 741091011473 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 741091011474 Mg++ binding site [ion binding]; other site 741091011475 putative catalytic motif [active] 741091011476 substrate binding site [chemical binding]; other site 741091011477 ornithine decarboxylase; Provisional; Region: PRK13578 741091011478 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 741091011479 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 741091011480 homodimer interface [polypeptide binding]; other site 741091011481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091011482 catalytic residue [active] 741091011483 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 741091011484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091011485 D-galactonate transporter; Region: 2A0114; TIGR00893 741091011486 putative substrate translocation pore; other site 741091011487 Domain of unknown function (DUF386); Region: DUF386; cl01047 741091011488 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 741091011489 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 741091011490 inhibitor site; inhibition site 741091011491 active site 741091011492 dimer interface [polypeptide binding]; other site 741091011493 catalytic residue [active] 741091011494 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 741091011495 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 741091011496 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741091011497 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 741091011498 substrate binding site [chemical binding]; other site 741091011499 dimer interface [polypeptide binding]; other site 741091011500 ATP binding site [chemical binding]; other site 741091011501 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 741091011502 putative catalytic site [active] 741091011503 putative metal binding site [ion binding]; other site 741091011504 putative phosphate binding site [ion binding]; other site 741091011505 cardiolipin synthase 2; Provisional; Region: PRK11263 741091011506 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 741091011507 putative active site [active] 741091011508 catalytic site [active] 741091011509 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 741091011510 putative active site [active] 741091011511 catalytic site [active] 741091011512 Predicted integral membrane protein [Function unknown]; Region: COG0392 741091011513 manganese transport protein MntH; Reviewed; Region: PRK00701 741091011514 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 741091011515 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 741091011516 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091011517 dimer interface [polypeptide binding]; other site 741091011518 putative CheW interface [polypeptide binding]; other site 741091011519 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 741091011520 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 741091011521 ligand binding site [chemical binding]; other site 741091011522 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 741091011523 Right handed beta helix region; Region: Beta_helix; pfam13229 741091011524 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 741091011525 Acyltransferase family; Region: Acyl_transf_3; pfam01757 741091011526 Transposase; Region: DEDD_Tnp_IS110; pfam01548 741091011527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 741091011528 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 741091011529 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 741091011530 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 741091011531 NADP-binding site; other site 741091011532 homotetramer interface [polypeptide binding]; other site 741091011533 substrate binding site [chemical binding]; other site 741091011534 homodimer interface [polypeptide binding]; other site 741091011535 active site 741091011536 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 741091011537 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 741091011538 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 741091011539 putative ADP-binding pocket [chemical binding]; other site 741091011540 phosphomannomutase CpsG; Provisional; Region: PRK15414 741091011541 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 741091011542 active site 741091011543 substrate binding site [chemical binding]; other site 741091011544 metal binding site [ion binding]; metal-binding site 741091011545 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 741091011546 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 741091011547 Substrate binding site; other site 741091011548 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 741091011549 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 741091011550 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 741091011551 putative ADP-binding pocket [chemical binding]; other site 741091011552 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 741091011553 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 741091011554 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 741091011555 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 741091011556 tyrosine kinase; Provisional; Region: PRK11519 741091011557 Chain length determinant protein; Region: Wzz; pfam02706 741091011558 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 741091011559 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 741091011560 Low molecular weight phosphatase family; Region: LMWPc; cd00115 741091011561 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 741091011562 active site 741091011563 polysaccharide export protein Wza; Provisional; Region: PRK15078 741091011564 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 741091011565 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 741091011566 Bacterial sugar transferase; Region: Bac_transf; pfam02397 741091011567 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 741091011568 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 741091011569 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 741091011570 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 741091011571 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 741091011572 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741091011573 DNA binding residues [nucleotide binding] 741091011574 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 741091011575 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 741091011576 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 741091011577 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 741091011578 Soluble P-type ATPase [General function prediction only]; Region: COG4087 741091011579 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 741091011580 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 741091011581 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091011582 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091011583 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 741091011584 Protein export membrane protein; Region: SecD_SecF; cl14618 741091011585 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 741091011586 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 741091011587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091011588 non-specific DNA binding site [nucleotide binding]; other site 741091011589 salt bridge; other site 741091011590 sequence-specific DNA binding site [nucleotide binding]; other site 741091011591 Cupin domain; Region: Cupin_2; pfam07883 741091011592 AzlC protein; Region: AzlC; cl00570 741091011593 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 741091011594 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 741091011595 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 741091011596 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 741091011597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091011598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091011599 LysE type translocator; Region: LysE; pfam01810 741091011600 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 741091011601 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 741091011602 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091011603 substrate binding pocket [chemical binding]; other site 741091011604 membrane-bound complex binding site; other site 741091011605 hinge residues; other site 741091011606 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 741091011607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091011608 dimer interface [polypeptide binding]; other site 741091011609 conserved gate region; other site 741091011610 putative PBP binding loops; other site 741091011611 ABC-ATPase subunit interface; other site 741091011612 transaminase; Validated; Region: PRK07324 741091011613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091011614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091011615 homodimer interface [polypeptide binding]; other site 741091011616 catalytic residue [active] 741091011617 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 741091011618 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 741091011619 putative sugar binding site [chemical binding]; other site 741091011620 catalytic residues [active] 741091011621 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 741091011622 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 741091011623 aromatic chitin/cellulose binding site residues [chemical binding]; other site 741091011624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091011625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091011626 LysR substrate binding domain; Region: LysR_substrate; pfam03466 741091011627 dimerization interface [polypeptide binding]; other site 741091011628 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 741091011629 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 741091011630 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 741091011631 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 741091011632 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 741091011633 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 741091011634 active site 741091011635 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 741091011636 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 741091011637 aromatic chitin/cellulose binding site residues [chemical binding]; other site 741091011638 transcriptional regulator; Provisional; Region: PRK10632 741091011639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091011640 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 741091011641 putative effector binding pocket; other site 741091011642 putative dimerization interface [polypeptide binding]; other site 741091011643 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 741091011644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091011645 putative substrate translocation pore; other site 741091011646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091011647 Spore Coat Protein U domain; Region: SCPU; pfam05229 741091011648 Spore Coat Protein U domain; Region: SCPU; pfam05229 741091011649 Spore Coat Protein U domain; Region: SCPU; pfam05229 741091011650 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 741091011651 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741091011652 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 741091011653 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741091011654 PapC C-terminal domain; Region: PapC_C; pfam13953 741091011655 Spore Coat Protein U domain; Region: SCPU; pfam05229 741091011656 Uncharacterized secreted protein [Function unknown]; Region: COG5430 741091011657 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 741091011658 DNA-binding site [nucleotide binding]; DNA binding site 741091011659 RNA-binding motif; other site 741091011660 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 741091011661 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 741091011662 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 741091011663 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 741091011664 shikimate binding site; other site 741091011665 NAD(P) binding site [chemical binding]; other site 741091011666 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 741091011667 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 741091011668 active site 741091011669 tetramer interface [polypeptide binding]; other site 741091011670 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 741091011671 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 741091011672 active site 741091011673 tetramer interface [polypeptide binding]; other site 741091011674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091011675 D-galactonate transporter; Region: 2A0114; TIGR00893 741091011676 putative substrate translocation pore; other site 741091011677 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 741091011678 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 741091011679 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 741091011680 serine endoprotease; Provisional; Region: PRK10942 741091011681 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 741091011682 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 741091011683 protein binding site [polypeptide binding]; other site 741091011684 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 741091011685 protein binding site [polypeptide binding]; other site 741091011686 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 741091011687 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 741091011688 Zn2+ binding site [ion binding]; other site 741091011689 Mg2+ binding site [ion binding]; other site 741091011690 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 741091011691 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 741091011692 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 741091011693 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 741091011694 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 741091011695 cobalamin binding residues [chemical binding]; other site 741091011696 putative BtuC binding residues; other site 741091011697 dimer interface [polypeptide binding]; other site 741091011698 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 741091011699 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 741091011700 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 741091011701 Cl- selectivity filter; other site 741091011702 Cl- binding residues [ion binding]; other site 741091011703 pore gating glutamate residue; other site 741091011704 dimer interface [polypeptide binding]; other site 741091011705 H+/Cl- coupling transport residue; other site 741091011706 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 741091011707 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741091011708 inhibitor-cofactor binding pocket; inhibition site 741091011709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091011710 catalytic residue [active] 741091011711 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 741091011712 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741091011713 ABC-ATPase subunit interface; other site 741091011714 dimer interface [polypeptide binding]; other site 741091011715 putative PBP binding regions; other site 741091011716 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741091011717 ABC-ATPase subunit interface; other site 741091011718 dimer interface [polypeptide binding]; other site 741091011719 putative PBP binding regions; other site 741091011720 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 741091011721 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 741091011722 siderophore binding site; other site 741091011723 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 741091011724 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 741091011725 Walker A/P-loop; other site 741091011726 ATP binding site [chemical binding]; other site 741091011727 Q-loop/lid; other site 741091011728 ABC transporter signature motif; other site 741091011729 Walker B; other site 741091011730 D-loop; other site 741091011731 H-loop/switch region; other site 741091011732 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 741091011733 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741091011734 N-terminal plug; other site 741091011735 ligand-binding site [chemical binding]; other site 741091011736 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 741091011737 Transglycosylase; Region: Transgly; pfam00912 741091011738 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 741091011739 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 741091011740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741091011741 ATP binding site [chemical binding]; other site 741091011742 putative Mg++ binding site [ion binding]; other site 741091011743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091011744 nucleotide binding region [chemical binding]; other site 741091011745 ATP-binding site [chemical binding]; other site 741091011746 Helicase associated domain (HA2); Region: HA2; pfam04408 741091011747 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 741091011748 2'-5' RNA ligase; Provisional; Region: PRK15124 741091011749 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 741091011750 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 741091011751 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 741091011752 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 741091011753 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 741091011754 active site 741091011755 nucleotide binding site [chemical binding]; other site 741091011756 HIGH motif; other site 741091011757 KMSKS motif; other site 741091011758 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 741091011759 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 741091011760 active site 741091011761 NTP binding site [chemical binding]; other site 741091011762 metal binding triad [ion binding]; metal-binding site 741091011763 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 741091011764 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 741091011765 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 741091011766 catalytic center binding site [active] 741091011767 ATP binding site [chemical binding]; other site 741091011768 sensor protein QseC; Provisional; Region: PRK10337 741091011769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091011770 dimer interface [polypeptide binding]; other site 741091011771 phosphorylation site [posttranslational modification] 741091011772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091011773 ATP binding site [chemical binding]; other site 741091011774 Mg2+ binding site [ion binding]; other site 741091011775 G-X-G motif; other site 741091011776 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 741091011777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091011778 active site 741091011779 phosphorylation site [posttranslational modification] 741091011780 intermolecular recognition site; other site 741091011781 dimerization interface [polypeptide binding]; other site 741091011782 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091011783 DNA binding site [nucleotide binding] 741091011784 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 741091011785 oligomerization interface [polypeptide binding]; other site 741091011786 active site 741091011787 metal binding site [ion binding]; metal-binding site 741091011788 Pantoate-beta-alanine ligase; Region: PanC; cd00560 741091011789 pantoate--beta-alanine ligase; Region: panC; TIGR00018 741091011790 active site 741091011791 ATP-binding site [chemical binding]; other site 741091011792 pantoate-binding site; other site 741091011793 HXXH motif; other site 741091011794 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 741091011795 tetramerization interface [polypeptide binding]; other site 741091011796 active site 741091011797 inner membrane transport permease; Provisional; Region: PRK15066 741091011798 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 741091011799 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 741091011800 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 741091011801 Walker A/P-loop; other site 741091011802 ATP binding site [chemical binding]; other site 741091011803 Q-loop/lid; other site 741091011804 ABC transporter signature motif; other site 741091011805 Walker B; other site 741091011806 D-loop; other site 741091011807 H-loop/switch region; other site 741091011808 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 741091011809 active site clefts [active] 741091011810 zinc binding site [ion binding]; other site 741091011811 dimer interface [polypeptide binding]; other site 741091011812 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 741091011813 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 741091011814 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741091011815 active site 741091011816 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 741091011817 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 741091011818 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741091011819 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 741091011820 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 741091011821 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 741091011822 putative NAD(P) binding site [chemical binding]; other site 741091011823 active site 741091011824 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 741091011825 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 741091011826 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 741091011827 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 741091011828 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 741091011829 multicopper oxidase; Provisional; Region: PRK10965 741091011830 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 741091011831 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 741091011832 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 741091011833 spermidine synthase; Provisional; Region: PRK00811 741091011834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091011835 S-adenosylmethionine binding site [chemical binding]; other site 741091011836 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 741091011837 aromatic amino acid exporter; Provisional; Region: PRK11689 741091011838 EamA-like transporter family; Region: EamA; pfam00892 741091011839 hypothetical protein; Provisional; Region: PRK05248 741091011840 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 741091011841 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 741091011842 substrate binding site [chemical binding]; other site 741091011843 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 741091011844 substrate binding site [chemical binding]; other site 741091011845 ligand binding site [chemical binding]; other site 741091011846 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741091011847 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741091011848 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 741091011849 hypothetical protein; Provisional; Region: PRK11622 741091011850 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 741091011851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091011852 dimer interface [polypeptide binding]; other site 741091011853 conserved gate region; other site 741091011854 putative PBP binding loops; other site 741091011855 ABC-ATPase subunit interface; other site 741091011856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091011857 dimer interface [polypeptide binding]; other site 741091011858 conserved gate region; other site 741091011859 putative PBP binding loops; other site 741091011860 ABC-ATPase subunit interface; other site 741091011861 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 741091011862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091011863 Walker A/P-loop; other site 741091011864 ATP binding site [chemical binding]; other site 741091011865 Q-loop/lid; other site 741091011866 ABC transporter signature motif; other site 741091011867 Walker B; other site 741091011868 D-loop; other site 741091011869 H-loop/switch region; other site 741091011870 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 741091011871 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 741091011872 active site 741091011873 catalytic site [active] 741091011874 MarR family; Region: MarR_2; pfam12802 741091011875 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 741091011876 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741091011877 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 741091011878 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 741091011879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741091011880 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 741091011881 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 741091011882 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 741091011883 E3 interaction surface; other site 741091011884 lipoyl attachment site [posttranslational modification]; other site 741091011885 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 741091011886 E3 interaction surface; other site 741091011887 lipoyl attachment site [posttranslational modification]; other site 741091011888 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 741091011889 E3 interaction surface; other site 741091011890 lipoyl attachment site [posttranslational modification]; other site 741091011891 e3 binding domain; Region: E3_binding; pfam02817 741091011892 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 741091011893 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 741091011894 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 741091011895 dimer interface [polypeptide binding]; other site 741091011896 TPP-binding site [chemical binding]; other site 741091011897 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 741091011898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091011899 DNA-binding site [nucleotide binding]; DNA binding site 741091011900 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 741091011901 aromatic amino acid transporter; Provisional; Region: PRK10238 741091011902 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 741091011903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091011904 putative substrate translocation pore; other site 741091011905 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 741091011906 active site 741091011907 regulatory protein AmpE; Provisional; Region: PRK10987 741091011908 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 741091011909 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 741091011910 amidase catalytic site [active] 741091011911 Zn binding residues [ion binding]; other site 741091011912 substrate binding site [chemical binding]; other site 741091011913 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 741091011914 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 741091011915 dimerization interface [polypeptide binding]; other site 741091011916 active site 741091011917 putative major pilin subunit; Provisional; Region: PRK10574 741091011918 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 741091011919 hypothetical protein; Provisional; Region: PRK10436 741091011920 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 741091011921 Walker A motif; other site 741091011922 ATP binding site [chemical binding]; other site 741091011923 Walker B motif; other site 741091011924 type IV pilin biogenesis protein; Provisional; Region: PRK10573 741091011925 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 741091011926 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 741091011927 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 741091011928 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 741091011929 active site 741091011930 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 741091011931 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 741091011932 CoA-binding site [chemical binding]; other site 741091011933 ATP-binding [chemical binding]; other site 741091011934 hypothetical protein; Provisional; Region: PRK05287 741091011935 DNA gyrase inhibitor; Reviewed; Region: PRK00418 741091011936 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 741091011937 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 741091011938 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 741091011939 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 741091011940 active site 741091011941 8-oxo-dGMP binding site [chemical binding]; other site 741091011942 nudix motif; other site 741091011943 metal binding site [ion binding]; metal-binding site 741091011944 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 741091011945 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 741091011946 SEC-C motif; Region: SEC-C; pfam02810 741091011947 SecA regulator SecM; Provisional; Region: PRK02943 741091011948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 741091011949 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 741091011950 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 741091011951 cell division protein FtsZ; Validated; Region: PRK09330 741091011952 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 741091011953 nucleotide binding site [chemical binding]; other site 741091011954 SulA interaction site; other site 741091011955 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 741091011956 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 741091011957 Cell division protein FtsA; Region: FtsA; pfam14450 741091011958 cell division protein FtsQ; Provisional; Region: PRK10775 741091011959 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 741091011960 Cell division protein FtsQ; Region: FtsQ; pfam03799 741091011961 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 741091011962 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 741091011963 ATP-grasp domain; Region: ATP-grasp_4; cl17255 741091011964 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 741091011965 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 741091011966 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 741091011967 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 741091011968 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 741091011969 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 741091011970 active site 741091011971 homodimer interface [polypeptide binding]; other site 741091011972 cell division protein FtsW; Provisional; Region: PRK10774 741091011973 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 741091011974 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 741091011975 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 741091011976 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 741091011977 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 741091011978 Mg++ binding site [ion binding]; other site 741091011979 putative catalytic motif [active] 741091011980 putative substrate binding site [chemical binding]; other site 741091011981 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 741091011982 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 741091011983 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 741091011984 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 741091011985 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 741091011986 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 741091011987 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 741091011988 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 741091011989 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 741091011990 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 741091011991 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 741091011992 cell division protein FtsL; Provisional; Region: PRK10772 741091011993 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 741091011994 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 741091011995 cell division protein MraZ; Reviewed; Region: PRK00326 741091011996 MraZ protein; Region: MraZ; pfam02381 741091011997 MraZ protein; Region: MraZ; pfam02381 741091011998 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 741091011999 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091012000 DNA binding site [nucleotide binding] 741091012001 domain linker motif; other site 741091012002 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 741091012003 dimerization interface [polypeptide binding]; other site 741091012004 ligand binding site [chemical binding]; other site 741091012005 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 741091012006 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 741091012007 putative valine binding site [chemical binding]; other site 741091012008 dimer interface [polypeptide binding]; other site 741091012009 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 741091012010 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 741091012011 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 741091012012 PYR/PP interface [polypeptide binding]; other site 741091012013 dimer interface [polypeptide binding]; other site 741091012014 TPP binding site [chemical binding]; other site 741091012015 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 741091012016 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 741091012017 TPP-binding site [chemical binding]; other site 741091012018 dimer interface [polypeptide binding]; other site 741091012019 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 741091012020 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 741091012021 acyl-activating enzyme (AAE) consensus motif; other site 741091012022 putative AMP binding site [chemical binding]; other site 741091012023 putative active site [active] 741091012024 putative CoA binding site [chemical binding]; other site 741091012025 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 741091012026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091012027 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 741091012028 putative substrate binding pocket [chemical binding]; other site 741091012029 putative dimerization interface [polypeptide binding]; other site 741091012030 2-isopropylmalate synthase; Validated; Region: PRK00915 741091012031 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 741091012032 active site 741091012033 catalytic residues [active] 741091012034 metal binding site [ion binding]; metal-binding site 741091012035 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 741091012036 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 741091012037 tartrate dehydrogenase; Region: TTC; TIGR02089 741091012038 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 741091012039 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 741091012040 substrate binding site [chemical binding]; other site 741091012041 ligand binding site [chemical binding]; other site 741091012042 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 741091012043 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 741091012044 substrate binding site [chemical binding]; other site 741091012045 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 741091012046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091012047 sugar efflux transporter; Region: 2A0120; TIGR00899 741091012048 putative substrate translocation pore; other site 741091012049 transcriptional regulator SgrR; Provisional; Region: PRK13626 741091012050 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 741091012051 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 741091012052 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 741091012053 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 741091012054 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 741091012055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091012056 dimer interface [polypeptide binding]; other site 741091012057 conserved gate region; other site 741091012058 putative PBP binding loops; other site 741091012059 ABC-ATPase subunit interface; other site 741091012060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091012061 dimer interface [polypeptide binding]; other site 741091012062 conserved gate region; other site 741091012063 putative PBP binding loops; other site 741091012064 ABC-ATPase subunit interface; other site 741091012065 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 741091012066 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 741091012067 Walker A/P-loop; other site 741091012068 ATP binding site [chemical binding]; other site 741091012069 Q-loop/lid; other site 741091012070 ABC transporter signature motif; other site 741091012071 Walker B; other site 741091012072 D-loop; other site 741091012073 H-loop/switch region; other site 741091012074 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 741091012075 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 741091012076 DNA polymerase II; Reviewed; Region: PRK05762 741091012077 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 741091012078 active site 741091012079 catalytic site [active] 741091012080 substrate binding site [chemical binding]; other site 741091012081 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 741091012082 active site 741091012083 metal-binding site 741091012084 ATP-dependent helicase HepA; Validated; Region: PRK04914 741091012085 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741091012086 ATP binding site [chemical binding]; other site 741091012087 putative Mg++ binding site [ion binding]; other site 741091012088 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091012089 nucleotide binding region [chemical binding]; other site 741091012090 ATP-binding site [chemical binding]; other site 741091012091 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 741091012092 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 741091012093 active site 741091012094 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 741091012095 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 741091012096 Autotransporter beta-domain; Region: Autotransporter; smart00869 741091012097 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 741091012098 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 741091012099 putative metal binding site [ion binding]; other site 741091012100 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 741091012101 HSP70 interaction site [polypeptide binding]; other site 741091012102 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 741091012103 OstA-like protein; Region: OstA; pfam03968 741091012104 Organic solvent tolerance protein; Region: OstA_C; pfam04453 741091012105 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 741091012106 SurA N-terminal domain; Region: SurA_N; pfam09312 741091012107 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 741091012108 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 741091012109 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 741091012110 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 741091012111 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 741091012112 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 741091012113 S-adenosylmethionine binding site [chemical binding]; other site 741091012114 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 741091012115 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 741091012116 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 741091012117 active site 741091012118 metal binding site [ion binding]; metal-binding site 741091012119 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 741091012120 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 741091012121 folate binding site [chemical binding]; other site 741091012122 NADP+ binding site [chemical binding]; other site 741091012123 hypothetical protein; Provisional; Region: PRK09917 741091012124 Uncharacterized conserved protein [Function unknown]; Region: COG2966 741091012125 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 741091012126 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 741091012127 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 741091012128 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 741091012129 TrkA-N domain; Region: TrkA_N; pfam02254 741091012130 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 741091012131 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 741091012132 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 741091012133 Glyco_18 domain; Region: Glyco_18; smart00636 741091012134 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 741091012135 active site 741091012136 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 741091012137 aromatic chitin/cellulose binding site residues [chemical binding]; other site 741091012138 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 741091012139 aromatic chitin/cellulose binding site residues [chemical binding]; other site 741091012140 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 741091012141 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 741091012142 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 741091012143 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 741091012144 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 741091012145 ATP-grasp domain; Region: ATP-grasp_4; cl17255 741091012146 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 741091012147 IMP binding site; other site 741091012148 dimer interface [polypeptide binding]; other site 741091012149 interdomain contacts; other site 741091012150 partial ornithine binding site; other site 741091012151 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 741091012152 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 741091012153 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 741091012154 catalytic site [active] 741091012155 subunit interface [polypeptide binding]; other site 741091012156 dihydrodipicolinate reductase; Provisional; Region: PRK00048 741091012157 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 741091012158 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 741091012159 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 741091012160 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741091012161 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 741091012162 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 741091012163 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 741091012164 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 741091012165 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 741091012166 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 741091012167 lipoprotein signal peptidase; Provisional; Region: PRK14787 741091012168 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 741091012169 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 741091012170 active site 741091012171 HIGH motif; other site 741091012172 nucleotide binding site [chemical binding]; other site 741091012173 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 741091012174 active site 741091012175 KMSKS motif; other site 741091012176 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 741091012177 tRNA binding surface [nucleotide binding]; other site 741091012178 anticodon binding site; other site 741091012179 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 741091012180 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 741091012181 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 741091012182 active site 741091012183 Riboflavin kinase; Region: Flavokinase; smart00904 741091012184 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 741091012185 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 741091012186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091012187 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 741091012188 putative dimerization interface [polypeptide binding]; other site 741091012189 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 741091012190 chaperone protein DnaJ; Provisional; Region: PRK10767 741091012191 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 741091012192 HSP70 interaction site [polypeptide binding]; other site 741091012193 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 741091012194 substrate binding site [polypeptide binding]; other site 741091012195 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 741091012196 Zn binding sites [ion binding]; other site 741091012197 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 741091012198 dimer interface [polypeptide binding]; other site 741091012199 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 741091012200 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 741091012201 nucleotide binding site [chemical binding]; other site 741091012202 hypothetical protein; Provisional; Region: PRK10659 741091012203 metabolite-proton symporter; Region: 2A0106; TIGR00883 741091012204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091012205 putative substrate translocation pore; other site 741091012206 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 741091012207 MPT binding site; other site 741091012208 trimer interface [polypeptide binding]; other site 741091012209 transaldolase-like protein; Provisional; Region: PTZ00411 741091012210 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 741091012211 active site 741091012212 dimer interface [polypeptide binding]; other site 741091012213 catalytic residue [active] 741091012214 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 741091012215 amino acid carrier protein; Region: agcS; TIGR00835 741091012216 hypothetical protein; Validated; Region: PRK02101 741091012217 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 741091012218 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 741091012219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091012220 catalytic residue [active] 741091012221 homoserine kinase; Provisional; Region: PRK01212 741091012222 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 741091012223 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 741091012224 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 741091012225 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 741091012226 putative catalytic residues [active] 741091012227 putative nucleotide binding site [chemical binding]; other site 741091012228 putative aspartate binding site [chemical binding]; other site 741091012229 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 741091012230 dimer interface [polypeptide binding]; other site 741091012231 putative threonine allosteric regulatory site; other site 741091012232 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 741091012233 putative threonine allosteric regulatory site; other site 741091012234 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 741091012235 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 741091012236 putative RNA methyltransferase; Provisional; Region: PRK10433 741091012237 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 741091012238 two-component response regulator; Provisional; Region: PRK11173 741091012239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091012240 active site 741091012241 phosphorylation site [posttranslational modification] 741091012242 intermolecular recognition site; other site 741091012243 dimerization interface [polypeptide binding]; other site 741091012244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091012245 DNA binding site [nucleotide binding] 741091012246 hypothetical protein; Provisional; Region: PRK10756 741091012247 CreA protein; Region: CreA; pfam05981 741091012248 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 741091012249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091012250 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 741091012251 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 741091012252 catalytic core [active] 741091012253 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 741091012254 Trp operon repressor; Provisional; Region: PRK01381 741091012255 lytic murein transglycosylase; Provisional; Region: PRK11619 741091012256 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741091012257 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741091012258 catalytic residue [active] 741091012259 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 741091012260 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 741091012261 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 741091012262 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 741091012263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091012264 motif II; other site 741091012265 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 741091012266 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 741091012267 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741091012268 DNA binding residues [nucleotide binding] 741091012269 dimerization interface [polypeptide binding]; other site 741091012270 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 741091012271 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091012272 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091012273 ABC transporter; Region: ABC_tran_2; pfam12848 741091012274 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091012275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091012276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091012277 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 741091012278 putative effector binding pocket; other site 741091012279 dimerization interface [polypeptide binding]; other site 741091012280 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 741091012281 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 741091012282 putative NAD(P) binding site [chemical binding]; other site 741091012283 dimer interface [polypeptide binding]; other site 741091012284 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 741091012285 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 741091012286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091012287 non-specific DNA binding site [nucleotide binding]; other site 741091012288 salt bridge; other site 741091012289 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 741091012290 sequence-specific DNA binding site [nucleotide binding]; other site 741091012291 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 741091012292 active site 741091012293 (T/H)XGH motif; other site 741091012294 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 741091012295 DNA repair protein RadA; Region: sms; TIGR00416 741091012296 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 741091012297 Walker A motif/ATP binding site; other site 741091012298 ATP binding site [chemical binding]; other site 741091012299 Walker B motif; other site 741091012300 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 741091012301 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 741091012302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091012303 motif II; other site 741091012304 hypothetical protein; Provisional; Region: PRK11246 741091012305 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 741091012306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091012307 putative Zn2+ binding site [ion binding]; other site 741091012308 HipA-like N-terminal domain; Region: HipA_N; pfam07805 741091012309 HipA-like C-terminal domain; Region: HipA_C; pfam07804 741091012310 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 741091012311 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 741091012312 phosphopentomutase; Provisional; Region: PRK05362 741091012313 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 741091012314 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 741091012315 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 741091012316 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 741091012317 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 741091012318 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 741091012319 intersubunit interface [polypeptide binding]; other site 741091012320 active site 741091012321 catalytic residue [active] 741091012322 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 741091012323 active site 741091012324 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 741091012325 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 741091012326 active site 741091012327 nucleophile elbow; other site 741091012328 periplasmic protein; Provisional; Region: PRK10568 741091012329 BON domain; Region: BON; pfam04972 741091012330 BON domain; Region: BON; pfam04972 741091012331 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 741091012332 aromatic chitin/cellulose binding site residues [chemical binding]; other site 741091012333 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 741091012334 active site 741091012335 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 741091012336 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 741091012337 G1 box; other site 741091012338 putative GEF interaction site [polypeptide binding]; other site 741091012339 GTP/Mg2+ binding site [chemical binding]; other site 741091012340 Switch I region; other site 741091012341 G2 box; other site 741091012342 G3 box; other site 741091012343 Switch II region; other site 741091012344 G4 box; other site 741091012345 G5 box; other site 741091012346 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 741091012347 HipA N-terminal domain; Region: Couple_hipA; pfam13657 741091012348 HipA-like N-terminal domain; Region: HipA_N; pfam07805 741091012349 HipA-like C-terminal domain; Region: HipA_C; pfam07804 741091012350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091012351 non-specific DNA binding site [nucleotide binding]; other site 741091012352 salt bridge; other site 741091012353 sequence-specific DNA binding site [nucleotide binding]; other site 741091012354 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 741091012355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091012356 Coenzyme A binding pocket [chemical binding]; other site 741091012357 DNA polymerase III subunit psi; Validated; Region: PRK06856 741091012358 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 741091012359 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 741091012360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091012361 S-adenosylmethionine binding site [chemical binding]; other site 741091012362 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091012363 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091012364 active site 741091012365 catalytic tetrad [active] 741091012366 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091012367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091012368 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091012369 dimerization interface [polypeptide binding]; other site 741091012370 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 741091012371 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091012372 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091012373 metal binding site [ion binding]; metal-binding site 741091012374 active site 741091012375 I-site; other site 741091012376 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 741091012377 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 741091012378 transcriptional activator RhaR; Provisional; Region: PRK13501 741091012379 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 741091012380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091012381 transcriptional activator RhaS; Provisional; Region: PRK13503 741091012382 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 741091012383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091012384 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 741091012385 N- and C-terminal domain interface [polypeptide binding]; other site 741091012386 active site 741091012387 putative catalytic site [active] 741091012388 metal binding site [ion binding]; metal-binding site 741091012389 ATP binding site [chemical binding]; other site 741091012390 rhamnulokinase; Provisional; Region: rhaB; PRK10640 741091012391 carbohydrate binding site [chemical binding]; other site 741091012392 L-rhamnose isomerase; Provisional; Region: PRK01076 741091012393 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 741091012394 intersubunit interface [polypeptide binding]; other site 741091012395 active site 741091012396 Zn2+ binding site [ion binding]; other site 741091012397 lactaldehyde reductase; Region: lactal_redase; TIGR02638 741091012398 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 741091012399 dimer interface [polypeptide binding]; other site 741091012400 active site 741091012401 metal binding site [ion binding]; metal-binding site 741091012402 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 741091012403 hypothetical protein; Provisional; Region: PRK01254 741091012404 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 741091012405 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 741091012406 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 741091012407 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 741091012408 DAK2 domain; Region: Dak2; pfam02734 741091012409 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 741091012410 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 741091012411 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 741091012412 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 741091012413 serine transporter; Region: stp; TIGR00814 741091012414 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 741091012415 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 741091012416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 741091012417 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091012418 metal binding site [ion binding]; metal-binding site 741091012419 active site 741091012420 I-site; other site 741091012421 putative outer membrane lipoprotein; Provisional; Region: PRK09967 741091012422 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741091012423 ligand binding site [chemical binding]; other site 741091012424 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 741091012425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091012426 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 741091012427 putative dimerization interface [polypeptide binding]; other site 741091012428 putative substrate binding pocket [chemical binding]; other site 741091012429 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 741091012430 acetolactate synthase; Reviewed; Region: PRK08617 741091012431 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 741091012432 PYR/PP interface [polypeptide binding]; other site 741091012433 dimer interface [polypeptide binding]; other site 741091012434 TPP binding site [chemical binding]; other site 741091012435 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 741091012436 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 741091012437 TPP-binding site [chemical binding]; other site 741091012438 dimer interface [polypeptide binding]; other site 741091012439 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 741091012440 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 741091012441 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 741091012442 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 741091012443 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 741091012444 trimer interface [polypeptide binding]; other site 741091012445 eyelet of channel; other site 741091012446 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741091012447 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 741091012448 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 741091012449 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 741091012450 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 741091012451 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 741091012452 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 741091012453 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 741091012454 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 741091012455 multifunctional aminopeptidase A; Provisional; Region: PRK00913 741091012456 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 741091012457 interface (dimer of trimers) [polypeptide binding]; other site 741091012458 Substrate-binding/catalytic site; other site 741091012459 Zn-binding sites [ion binding]; other site 741091012460 DNA polymerase III subunit chi; Validated; Region: PRK05728 741091012461 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 741091012462 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 741091012463 HIGH motif; other site 741091012464 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 741091012465 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 741091012466 active site 741091012467 KMSKS motif; other site 741091012468 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 741091012469 tRNA binding surface [nucleotide binding]; other site 741091012470 anticodon binding site; other site 741091012471 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 741091012472 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 741091012473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091012474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091012475 dimerization interface [polypeptide binding]; other site 741091012476 Fimbrial protein; Region: Fimbrial; pfam00419 741091012477 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 741091012478 PapC N-terminal domain; Region: PapC_N; pfam13954 741091012479 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741091012480 PapC C-terminal domain; Region: PapC_C; pfam13953 741091012481 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 741091012482 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741091012483 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741091012484 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741091012485 Fimbrial protein; Region: Fimbrial; pfam00419 741091012486 Peptidase family M48; Region: Peptidase_M48; cl12018 741091012487 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 741091012488 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 741091012489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091012490 Coenzyme A binding pocket [chemical binding]; other site 741091012491 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 741091012492 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741091012493 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 741091012494 putative active site [active] 741091012495 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 741091012496 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741091012497 active site turn [active] 741091012498 phosphorylation site [posttranslational modification] 741091012499 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741091012500 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 741091012501 beta-galactosidase; Region: BGL; TIGR03356 741091012502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 741091012503 RNase E inhibitor protein; Provisional; Region: PRK11191 741091012504 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 741091012505 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 741091012506 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 741091012507 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 741091012508 active site 741091012509 homodimer interface [polypeptide binding]; other site 741091012510 catalytic site [active] 741091012511 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 741091012512 arginine deiminase; Provisional; Region: PRK01388 741091012513 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 741091012514 putative substrate binding site [chemical binding]; other site 741091012515 homodimer interface [polypeptide binding]; other site 741091012516 nucleotide binding site [chemical binding]; other site 741091012517 nucleotide binding site [chemical binding]; other site 741091012518 ornithine carbamoyltransferase; Validated; Region: PRK02102 741091012519 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 741091012520 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 741091012521 Predicted membrane protein [Function unknown]; Region: COG1288 741091012522 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 741091012523 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 741091012524 arginine repressor; Provisional; Region: argR; PRK00441 741091012525 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 741091012526 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 741091012527 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 741091012528 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 741091012529 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 741091012530 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 741091012531 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 741091012532 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 741091012533 homotrimer interaction site [polypeptide binding]; other site 741091012534 putative active site [active] 741091012535 Peptidase family M23; Region: Peptidase_M23; pfam01551 741091012536 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 741091012537 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 741091012538 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 741091012539 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 741091012540 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 741091012541 Uncharacterized conserved protein [Function unknown]; Region: COG2308 741091012542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 741091012543 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 741091012544 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 741091012545 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 741091012546 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 741091012547 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 741091012548 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 741091012549 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741091012550 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091012551 DNA binding site [nucleotide binding] 741091012552 domain linker motif; other site 741091012553 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 741091012554 putative dimerization interface [polypeptide binding]; other site 741091012555 putative ligand binding site [chemical binding]; other site 741091012556 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 741091012557 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 741091012558 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 741091012559 Walker A/P-loop; other site 741091012560 ATP binding site [chemical binding]; other site 741091012561 Q-loop/lid; other site 741091012562 ABC transporter signature motif; other site 741091012563 Walker B; other site 741091012564 D-loop; other site 741091012565 H-loop/switch region; other site 741091012566 TOBE domain; Region: TOBE_2; pfam08402 741091012567 beta-phosphoglucomutase; Region: bPGM; TIGR01990 741091012568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091012569 motif II; other site 741091012570 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 741091012571 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 741091012572 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 741091012573 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 741091012574 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 741091012575 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 741091012576 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 741091012577 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 741091012578 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 741091012579 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 741091012580 putative NAD(P) binding site [chemical binding]; other site 741091012581 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741091012582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091012583 dimer interface [polypeptide binding]; other site 741091012584 conserved gate region; other site 741091012585 putative PBP binding loops; other site 741091012586 ABC-ATPase subunit interface; other site 741091012587 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 741091012588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091012589 dimer interface [polypeptide binding]; other site 741091012590 conserved gate region; other site 741091012591 putative PBP binding loops; other site 741091012592 ABC-ATPase subunit interface; other site 741091012593 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 741091012594 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 741091012595 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 741091012596 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 741091012597 active site 741091012598 homodimer interface [polypeptide binding]; other site 741091012599 catalytic site [active] 741091012600 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 741091012601 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 741091012602 galactarate dehydratase; Region: galactar-dH20; TIGR03248 741091012603 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 741091012604 altronate oxidoreductase; Provisional; Region: PRK03643 741091012605 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 741091012606 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 741091012607 Glucuronate isomerase; Region: UxaC; pfam02614 741091012608 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 741091012609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091012610 D-galactonate transporter; Region: 2A0114; TIGR00893 741091012611 putative substrate translocation pore; other site 741091012612 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 741091012613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091012614 DNA-binding site [nucleotide binding]; DNA binding site 741091012615 FCD domain; Region: FCD; pfam07729 741091012616 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 741091012617 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 741091012618 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 741091012619 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 741091012620 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 741091012621 Predicted membrane protein [Function unknown]; Region: COG5393 741091012622 YqjK-like protein; Region: YqjK; pfam13997 741091012623 Predicted membrane protein [Function unknown]; Region: COG2259 741091012624 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 741091012625 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 741091012626 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 741091012627 putative dimer interface [polypeptide binding]; other site 741091012628 N-terminal domain interface [polypeptide binding]; other site 741091012629 putative substrate binding pocket (H-site) [chemical binding]; other site 741091012630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091012631 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 741091012632 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091012633 dimerization interface [polypeptide binding]; other site 741091012634 Pirin-related protein [General function prediction only]; Region: COG1741 741091012635 Pirin; Region: Pirin; pfam02678 741091012636 Toxin-coregulated pilus subunit TcpA; Region: TcpA; pfam05946 741091012637 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 741091012638 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 741091012639 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 741091012640 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 741091012641 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 741091012642 Type II/IV secretion system protein; Region: T2SE; pfam00437 741091012643 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 741091012644 Walker A motif; other site 741091012645 ATP binding site [chemical binding]; other site 741091012646 Walker B motif; other site 741091012647 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 741091012648 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 741091012649 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 741091012650 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 741091012651 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 741091012652 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 741091012653 Peptidase family M23; Region: Peptidase_M23; pfam01551 741091012654 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 741091012655 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 741091012656 putative SAM binding site [chemical binding]; other site 741091012657 putative homodimer interface [polypeptide binding]; other site 741091012658 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 741091012659 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 741091012660 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 741091012661 putative ligand binding site [chemical binding]; other site 741091012662 hypothetical protein; Reviewed; Region: PRK12497 741091012663 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 741091012664 dimer interface [polypeptide binding]; other site 741091012665 active site 741091012666 outer membrane lipoprotein; Provisional; Region: PRK11023 741091012667 BON domain; Region: BON; pfam04972 741091012668 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 741091012669 Transglycosylase; Region: Transgly; cl17702 741091012670 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 741091012671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091012672 putative active site [active] 741091012673 heme pocket [chemical binding]; other site 741091012674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091012675 dimer interface [polypeptide binding]; other site 741091012676 phosphorylation site [posttranslational modification] 741091012677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091012678 ATP binding site [chemical binding]; other site 741091012679 Mg2+ binding site [ion binding]; other site 741091012680 G-X-G motif; other site 741091012681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091012682 active site 741091012683 phosphorylation site [posttranslational modification] 741091012684 intermolecular recognition site; other site 741091012685 dimerization interface [polypeptide binding]; other site 741091012686 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 741091012687 putative binding surface; other site 741091012688 active site 741091012689 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 741091012690 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 741091012691 active site 741091012692 dimer interface [polypeptide binding]; other site 741091012693 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 741091012694 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 741091012695 active site 741091012696 FMN binding site [chemical binding]; other site 741091012697 substrate binding site [chemical binding]; other site 741091012698 3Fe-4S cluster binding site [ion binding]; other site 741091012699 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 741091012700 domain interface; other site 741091012701 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 741091012702 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 741091012703 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 741091012704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741091012705 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 741091012706 stringent starvation protein A; Provisional; Region: sspA; PRK09481 741091012707 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 741091012708 C-terminal domain interface [polypeptide binding]; other site 741091012709 putative GSH binding site (G-site) [chemical binding]; other site 741091012710 dimer interface [polypeptide binding]; other site 741091012711 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 741091012712 dimer interface [polypeptide binding]; other site 741091012713 N-terminal domain interface [polypeptide binding]; other site 741091012714 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 741091012715 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 741091012716 23S rRNA interface [nucleotide binding]; other site 741091012717 L3 interface [polypeptide binding]; other site 741091012718 Predicted ATPase [General function prediction only]; Region: COG1485 741091012719 hypothetical protein; Provisional; Region: PRK11677 741091012720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 741091012721 serine endoprotease; Provisional; Region: PRK10139 741091012722 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 741091012723 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 741091012724 protein binding site [polypeptide binding]; other site 741091012725 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 741091012726 protein binding site [polypeptide binding]; other site 741091012727 serine endoprotease; Provisional; Region: PRK10898 741091012728 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 741091012729 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 741091012730 protein binding site [polypeptide binding]; other site 741091012731 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 741091012732 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 741091012733 hinge; other site 741091012734 active site 741091012735 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 741091012736 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 741091012737 anti sigma factor interaction site; other site 741091012738 regulatory phosphorylation site [posttranslational modification]; other site 741091012739 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 741091012740 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 741091012741 mce related protein; Region: MCE; pfam02470 741091012742 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 741091012743 conserved hypothetical integral membrane protein; Region: TIGR00056 741091012744 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 741091012745 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 741091012746 Walker A/P-loop; other site 741091012747 ATP binding site [chemical binding]; other site 741091012748 Q-loop/lid; other site 741091012749 ABC transporter signature motif; other site 741091012750 Walker B; other site 741091012751 D-loop; other site 741091012752 H-loop/switch region; other site 741091012753 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 741091012754 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 741091012755 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 741091012756 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 741091012757 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 741091012758 putative active site [active] 741091012759 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 741091012760 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 741091012761 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 741091012762 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 741091012763 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 741091012764 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 741091012765 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 741091012766 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 741091012767 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 741091012768 Walker A/P-loop; other site 741091012769 ATP binding site [chemical binding]; other site 741091012770 Q-loop/lid; other site 741091012771 ABC transporter signature motif; other site 741091012772 Walker B; other site 741091012773 D-loop; other site 741091012774 H-loop/switch region; other site 741091012775 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 741091012776 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 741091012777 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 741091012778 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 741091012779 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 741091012780 30S subunit binding site; other site 741091012781 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741091012782 active site 741091012783 phosphorylation site [posttranslational modification] 741091012784 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 741091012785 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 741091012786 dimerization domain swap beta strand [polypeptide binding]; other site 741091012787 regulatory protein interface [polypeptide binding]; other site 741091012788 active site 741091012789 regulatory phosphorylation site [posttranslational modification]; other site 741091012790 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 741091012791 HTH domain; Region: HTH_11; pfam08279 741091012792 Mga helix-turn-helix domain; Region: Mga; pfam05043 741091012793 PRD domain; Region: PRD; pfam00874 741091012794 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 741091012795 active site 741091012796 P-loop; other site 741091012797 phosphorylation site [posttranslational modification] 741091012798 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741091012799 active site 741091012800 phosphorylation site [posttranslational modification] 741091012801 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 741091012802 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 741091012803 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 741091012804 catalytic residue [active] 741091012805 dihydroorotase; Provisional; Region: PRK09237 741091012806 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 741091012807 active site 741091012808 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 741091012809 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 741091012810 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 741091012811 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 741091012812 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 741091012813 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 741091012814 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 741091012815 Cytochrome b562; Region: Cytochrom_B562; cl01546 741091012816 peptidase PmbA; Provisional; Region: PRK11040 741091012817 hypothetical protein; Provisional; Region: PRK05255 741091012818 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 741091012819 RNAase interaction site [polypeptide binding]; other site 741091012820 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 741091012821 active site 741091012822 succinic semialdehyde dehydrogenase; Region: PLN02278 741091012823 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 741091012824 tetramerization interface [polypeptide binding]; other site 741091012825 NAD(P) binding site [chemical binding]; other site 741091012826 catalytic residues [active] 741091012827 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 741091012828 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 741091012829 active site 741091012830 substrate binding site [chemical binding]; other site 741091012831 trimer interface [polypeptide binding]; other site 741091012832 CoA binding site [chemical binding]; other site 741091012833 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 741091012834 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 741091012835 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 741091012836 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 741091012837 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091012838 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091012839 efflux system membrane protein; Provisional; Region: PRK11594 741091012840 transcriptional regulator; Provisional; Region: PRK10632 741091012841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091012842 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 741091012843 putative effector binding pocket; other site 741091012844 dimerization interface [polypeptide binding]; other site 741091012845 protease TldD; Provisional; Region: tldD; PRK10735 741091012846 hypothetical protein; Provisional; Region: PRK10899 741091012847 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 741091012848 ribonuclease G; Provisional; Region: PRK11712 741091012849 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 741091012850 homodimer interface [polypeptide binding]; other site 741091012851 oligonucleotide binding site [chemical binding]; other site 741091012852 Maf-like protein; Region: Maf; pfam02545 741091012853 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 741091012854 active site 741091012855 dimer interface [polypeptide binding]; other site 741091012856 rod shape-determining protein MreD; Provisional; Region: PRK11060 741091012857 rod shape-determining protein MreC; Region: mreC; TIGR00219 741091012858 rod shape-determining protein MreC; Region: MreC; pfam04085 741091012859 rod shape-determining protein MreB; Provisional; Region: PRK13927 741091012860 MreB and similar proteins; Region: MreB_like; cd10225 741091012861 nucleotide binding site [chemical binding]; other site 741091012862 Mg binding site [ion binding]; other site 741091012863 putative protofilament interaction site [polypeptide binding]; other site 741091012864 RodZ interaction site [polypeptide binding]; other site 741091012865 regulatory protein CsrD; Provisional; Region: PRK11059 741091012866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091012867 metal binding site [ion binding]; metal-binding site 741091012868 active site 741091012869 I-site; other site 741091012870 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091012871 TMAO/DMSO reductase; Reviewed; Region: PRK05363 741091012872 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 741091012873 Moco binding site; other site 741091012874 metal coordination site [ion binding]; other site 741091012875 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 741091012876 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 741091012877 Dehydroquinase class II; Region: DHquinase_II; pfam01220 741091012878 active site 741091012879 trimer interface [polypeptide binding]; other site 741091012880 dimer interface [polypeptide binding]; other site 741091012881 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 741091012882 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 741091012883 carboxyltransferase (CT) interaction site; other site 741091012884 biotinylation site [posttranslational modification]; other site 741091012885 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 741091012886 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 741091012887 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 741091012888 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 741091012889 hypothetical protein; Provisional; Region: PRK10633 741091012890 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 741091012891 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 741091012892 Na binding site [ion binding]; other site 741091012893 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 741091012894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091012895 S-adenosylmethionine binding site [chemical binding]; other site 741091012896 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 741091012897 active site 741091012898 zinc binding site [ion binding]; other site 741091012899 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 741091012900 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 741091012901 FMN binding site [chemical binding]; other site 741091012902 active site 741091012903 catalytic residues [active] 741091012904 substrate binding site [chemical binding]; other site 741091012905 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 741091012906 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 741091012907 Predicted membrane protein [Function unknown]; Region: COG2259 741091012908 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 741091012909 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 741091012910 putative acyl-acceptor binding pocket; other site 741091012911 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 741091012912 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091012913 substrate binding pocket [chemical binding]; other site 741091012914 membrane-bound complex binding site; other site 741091012915 hinge residues; other site 741091012916 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 741091012917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091012918 conserved gate region; other site 741091012919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091012920 dimer interface [polypeptide binding]; other site 741091012921 conserved gate region; other site 741091012922 putative PBP binding loops; other site 741091012923 ABC-ATPase subunit interface; other site 741091012924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091012925 dimer interface [polypeptide binding]; other site 741091012926 conserved gate region; other site 741091012927 putative PBP binding loops; other site 741091012928 ABC-ATPase subunit interface; other site 741091012929 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 741091012930 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 741091012931 Walker A/P-loop; other site 741091012932 ATP binding site [chemical binding]; other site 741091012933 Q-loop/lid; other site 741091012934 ABC transporter signature motif; other site 741091012935 Walker B; other site 741091012936 D-loop; other site 741091012937 H-loop/switch region; other site 741091012938 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 741091012939 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 741091012940 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091012941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091012942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091012943 dimerization interface [polypeptide binding]; other site 741091012944 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 741091012945 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 741091012946 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 741091012947 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 741091012948 putative C-terminal domain interface [polypeptide binding]; other site 741091012949 putative GSH binding site (G-site) [chemical binding]; other site 741091012950 putative dimer interface [polypeptide binding]; other site 741091012951 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 741091012952 putative N-terminal domain interface [polypeptide binding]; other site 741091012953 putative dimer interface [polypeptide binding]; other site 741091012954 putative substrate binding pocket (H-site) [chemical binding]; other site 741091012955 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 741091012956 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 741091012957 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091012958 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091012959 metal binding site [ion binding]; metal-binding site 741091012960 active site 741091012961 I-site; other site 741091012962 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091012963 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 741091012964 HAMP domain; Region: HAMP; pfam00672 741091012965 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 741091012966 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091012967 dimer interface [polypeptide binding]; other site 741091012968 putative CheW interface [polypeptide binding]; other site 741091012969 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 741091012970 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 741091012971 active site 741091012972 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 741091012973 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 741091012974 putative ligand binding residues [chemical binding]; other site 741091012975 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 741091012976 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 741091012977 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 741091012978 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 741091012979 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 741091012980 ATP binding site [chemical binding]; other site 741091012981 Male sterility protein; Region: NAD_binding_4; pfam07993 741091012982 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 741091012983 NAD(P) binding site [chemical binding]; other site 741091012984 active site 741091012985 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 741091012986 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 741091012987 putative C-terminal domain interface [polypeptide binding]; other site 741091012988 putative GSH binding site (G-site) [chemical binding]; other site 741091012989 putative dimer interface [polypeptide binding]; other site 741091012990 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 741091012991 putative N-terminal domain interface [polypeptide binding]; other site 741091012992 putative dimer interface [polypeptide binding]; other site 741091012993 putative substrate binding pocket (H-site) [chemical binding]; other site 741091012994 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 741091012995 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 741091012996 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 741091012997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091012998 EamA-like transporter family; Region: EamA; pfam00892 741091012999 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 741091013000 active site 1 [active] 741091013001 dimer interface [polypeptide binding]; other site 741091013002 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 741091013003 hexamer interface [polypeptide binding]; other site 741091013004 active site 2 [active] 741091013005 PemK-like protein; Region: PemK; cl00995 741091013006 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 741091013007 short chain dehydrogenase; Provisional; Region: PRK12937 741091013008 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 741091013009 NADP binding site [chemical binding]; other site 741091013010 homodimer interface [polypeptide binding]; other site 741091013011 active site 741091013012 substrate binding site [chemical binding]; other site 741091013013 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091013014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091013015 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 741091013016 putative effector binding pocket; other site 741091013017 putative dimerization interface [polypeptide binding]; other site 741091013018 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 741091013019 salicylate hydroxylase; Provisional; Region: PRK08163 741091013020 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 741091013021 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741091013022 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 741091013023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091013024 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091013025 dimerization interface [polypeptide binding]; other site 741091013026 putative deaminase; Validated; Region: PRK06846 741091013027 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 741091013028 active site 741091013029 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 741091013030 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 741091013031 dimer interface [polypeptide binding]; other site 741091013032 ssDNA binding site [nucleotide binding]; other site 741091013033 tetramer (dimer of dimers) interface [polypeptide binding]; other site 741091013034 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 741091013035 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 741091013036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091013037 ABC transporter signature motif; other site 741091013038 Walker B; other site 741091013039 D-loop; other site 741091013040 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 741091013041 Helix-turn-helix domain; Region: HTH_36; pfam13730 741091013042 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 741091013043 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 741091013044 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 741091013045 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091013046 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091013047 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 741091013048 putative effector binding pocket; other site 741091013049 putative dimerization interface [polypeptide binding]; other site 741091013050 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 741091013051 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 741091013052 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 741091013053 putative N-terminal domain interface [polypeptide binding]; other site 741091013054 putative dimer interface [polypeptide binding]; other site 741091013055 putative substrate binding pocket (H-site) [chemical binding]; other site 741091013056 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 741091013057 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 741091013058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 741091013059 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 741091013060 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 741091013061 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 741091013062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091013063 putative substrate translocation pore; other site 741091013064 alpha-glucosidase; Provisional; Region: PRK10426 741091013065 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 741091013066 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 741091013067 putative active site [active] 741091013068 putative catalytic site [active] 741091013069 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 741091013070 dimerization interface [polypeptide binding]; other site 741091013071 putative active cleft [active] 741091013072 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 741091013073 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 741091013074 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 741091013075 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741091013076 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 741091013077 substrate binding site [chemical binding]; other site 741091013078 ATP binding site [chemical binding]; other site 741091013079 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 741091013080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091013081 putative DNA binding site [nucleotide binding]; other site 741091013082 putative Zn2+ binding site [ion binding]; other site 741091013083 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 741091013084 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 741091013085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091013086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091013087 homodimer interface [polypeptide binding]; other site 741091013088 catalytic residue [active] 741091013089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091013090 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 741091013091 Uncharacterized conserved protein [Function unknown]; Region: COG1284 741091013092 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 741091013093 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 741091013094 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 741091013095 AsnC family; Region: AsnC_trans_reg; pfam01037 741091013096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091013097 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 741091013098 substrate binding pocket [chemical binding]; other site 741091013099 membrane-bound complex binding site; other site 741091013100 hinge residues; other site 741091013101 alanine racemase; Reviewed; Region: alr; PRK00053 741091013102 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 741091013103 active site 741091013104 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 741091013105 substrate binding site [chemical binding]; other site 741091013106 catalytic residues [active] 741091013107 dimer interface [polypeptide binding]; other site 741091013108 replicative DNA helicase; Provisional; Region: PRK08006 741091013109 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 741091013110 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 741091013111 Walker A motif; other site 741091013112 ATP binding site [chemical binding]; other site 741091013113 Walker B motif; other site 741091013114 DNA binding loops [nucleotide binding] 741091013115 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 741091013116 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 741091013117 NADP binding site [chemical binding]; other site 741091013118 dimer interface [polypeptide binding]; other site 741091013119 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 741091013120 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 741091013121 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 741091013122 FMN binding site [chemical binding]; other site 741091013123 active site 741091013124 catalytic residues [active] 741091013125 substrate binding site [chemical binding]; other site 741091013126 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 741091013127 metal binding site 2 [ion binding]; metal-binding site 741091013128 putative DNA binding helix; other site 741091013129 metal binding site 1 [ion binding]; metal-binding site 741091013130 dimer interface [polypeptide binding]; other site 741091013131 structural Zn2+ binding site [ion binding]; other site 741091013132 hypothetical protein; Provisional; Region: PRK10428 741091013133 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 741091013134 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 741091013135 LexA repressor; Validated; Region: PRK00215 741091013136 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 741091013137 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 741091013138 Catalytic site [active] 741091013139 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 741091013140 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 741091013141 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 741091013142 putative acyl-acceptor binding pocket; other site 741091013143 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 741091013144 UbiA prenyltransferase family; Region: UbiA; pfam01040 741091013145 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 741091013146 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 741091013147 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 741091013148 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 741091013149 active site 741091013150 dimer interface [polypeptide binding]; other site 741091013151 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 741091013152 dimer interface [polypeptide binding]; other site 741091013153 active site 741091013154 aspartate kinase III; Validated; Region: PRK09084 741091013155 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 741091013156 nucleotide binding site [chemical binding]; other site 741091013157 substrate binding site [chemical binding]; other site 741091013158 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 741091013159 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 741091013160 dimer interface [polypeptide binding]; other site 741091013161 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 741091013162 Sodium Bile acid symporter family; Region: SBF; pfam01758 741091013163 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 741091013164 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 741091013165 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 741091013166 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 741091013167 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 741091013168 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 741091013169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091013170 Walker A/P-loop; other site 741091013171 ATP binding site [chemical binding]; other site 741091013172 Q-loop/lid; other site 741091013173 ABC transporter signature motif; other site 741091013174 Walker B; other site 741091013175 D-loop; other site 741091013176 H-loop/switch region; other site 741091013177 TOBE domain; Region: TOBE_2; pfam08402 741091013178 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 741091013179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091013180 dimer interface [polypeptide binding]; other site 741091013181 conserved gate region; other site 741091013182 putative PBP binding loops; other site 741091013183 ABC-ATPase subunit interface; other site 741091013184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 741091013185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091013186 putative PBP binding loops; other site 741091013187 ABC-ATPase subunit interface; other site 741091013188 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 741091013189 Sulfatase; Region: Sulfatase; cl17466 741091013190 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 741091013191 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 741091013192 transcriptional regulator protein; Region: phnR; TIGR03337 741091013193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091013194 DNA-binding site [nucleotide binding]; DNA binding site 741091013195 UTRA domain; Region: UTRA; pfam07702 741091013196 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 741091013197 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 741091013198 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 741091013199 substrate binding pocket [chemical binding]; other site 741091013200 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 741091013201 B12 binding site [chemical binding]; other site 741091013202 cobalt ligand [ion binding]; other site 741091013203 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 741091013204 transcriptional repressor IclR; Provisional; Region: PRK11569 741091013205 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 741091013206 Bacterial transcriptional regulator; Region: IclR; pfam01614 741091013207 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 741091013208 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 741091013209 isocitrate lyase; Provisional; Region: PRK15063 741091013210 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 741091013211 tetramer interface [polypeptide binding]; other site 741091013212 active site 741091013213 Mg2+/Mn2+ binding site [ion binding]; other site 741091013214 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 741091013215 malate synthase A; Region: malate_syn_A; TIGR01344 741091013216 active site 741091013217 homoserine O-succinyltransferase; Provisional; Region: PRK05368 741091013218 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 741091013219 proposed active site lysine [active] 741091013220 conserved cys residue [active] 741091013221 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 741091013222 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 741091013223 purine monophosphate binding site [chemical binding]; other site 741091013224 dimer interface [polypeptide binding]; other site 741091013225 putative catalytic residues [active] 741091013226 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 741091013227 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 741091013228 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 741091013229 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 741091013230 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 741091013231 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 741091013232 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 741091013233 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 741091013234 IHF dimer interface [polypeptide binding]; other site 741091013235 IHF - DNA interface [nucleotide binding]; other site 741091013236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 741091013237 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 741091013238 Active_site [active] 741091013239 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 741091013240 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 741091013241 substrate binding site [chemical binding]; other site 741091013242 active site 741091013243 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 741091013244 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 741091013245 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 741091013246 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 741091013247 putative NADH binding site [chemical binding]; other site 741091013248 putative active site [active] 741091013249 nudix motif; other site 741091013250 putative metal binding site [ion binding]; other site 741091013251 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 741091013252 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 741091013253 ThiC-associated domain; Region: ThiC-associated; pfam13667 741091013254 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 741091013255 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 741091013256 thiamine phosphate binding site [chemical binding]; other site 741091013257 active site 741091013258 pyrophosphate binding site [ion binding]; other site 741091013259 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 741091013260 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 741091013261 ATP binding site [chemical binding]; other site 741091013262 substrate interface [chemical binding]; other site 741091013263 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 741091013264 thiS-thiF/thiG interaction site; other site 741091013265 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 741091013266 ThiS interaction site; other site 741091013267 putative active site [active] 741091013268 tetramer interface [polypeptide binding]; other site 741091013269 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 741091013270 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091013271 FeS/SAM binding site; other site 741091013272 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 741091013273 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 741091013274 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 741091013275 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 741091013276 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 741091013277 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 741091013278 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 741091013279 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 741091013280 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 741091013281 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 741091013282 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 741091013283 DNA binding site [nucleotide binding] 741091013284 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 741091013285 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 741091013286 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 741091013287 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 741091013288 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 741091013289 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 741091013290 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 741091013291 RPB3 interaction site [polypeptide binding]; other site 741091013292 RPB1 interaction site [polypeptide binding]; other site 741091013293 RPB11 interaction site [polypeptide binding]; other site 741091013294 RPB10 interaction site [polypeptide binding]; other site 741091013295 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 741091013296 core dimer interface [polypeptide binding]; other site 741091013297 peripheral dimer interface [polypeptide binding]; other site 741091013298 L10 interface [polypeptide binding]; other site 741091013299 L11 interface [polypeptide binding]; other site 741091013300 putative EF-Tu interaction site [polypeptide binding]; other site 741091013301 putative EF-G interaction site [polypeptide binding]; other site 741091013302 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 741091013303 23S rRNA interface [nucleotide binding]; other site 741091013304 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 741091013305 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 741091013306 mRNA/rRNA interface [nucleotide binding]; other site 741091013307 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 741091013308 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 741091013309 23S rRNA interface [nucleotide binding]; other site 741091013310 L7/L12 interface [polypeptide binding]; other site 741091013311 putative thiostrepton binding site; other site 741091013312 L25 interface [polypeptide binding]; other site 741091013313 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 741091013314 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 741091013315 putative homodimer interface [polypeptide binding]; other site 741091013316 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 741091013317 heterodimer interface [polypeptide binding]; other site 741091013318 homodimer interface [polypeptide binding]; other site 741091013319 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 741091013320 elongation factor Tu; Reviewed; Region: PRK00049 741091013321 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 741091013322 G1 box; other site 741091013323 GEF interaction site [polypeptide binding]; other site 741091013324 GTP/Mg2+ binding site [chemical binding]; other site 741091013325 Switch I region; other site 741091013326 G2 box; other site 741091013327 G3 box; other site 741091013328 Switch II region; other site 741091013329 G4 box; other site 741091013330 G5 box; other site 741091013331 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 741091013332 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 741091013333 Antibiotic Binding Site [chemical binding]; other site 741091013334 pantothenate kinase; Provisional; Region: PRK05439 741091013335 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 741091013336 ATP-binding site [chemical binding]; other site 741091013337 CoA-binding site [chemical binding]; other site 741091013338 Mg2+-binding site [ion binding]; other site 741091013339 Biotin operon repressor [Transcription]; Region: BirA; COG1654 741091013340 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 741091013341 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 741091013342 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 741091013343 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 741091013344 FAD binding domain; Region: FAD_binding_4; pfam01565 741091013345 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 741091013346 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 741091013347 potassium transporter; Provisional; Region: PRK10750 741091013348 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 741091013349 hypothetical protein; Provisional; Region: PRK11568 741091013350 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 741091013351 proline dipeptidase; Provisional; Region: PRK13607 741091013352 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 741091013353 active site 741091013354 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 741091013355 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 741091013356 substrate binding site [chemical binding]; other site 741091013357 oxyanion hole (OAH) forming residues; other site 741091013358 trimer interface [polypeptide binding]; other site 741091013359 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 741091013360 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 741091013361 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 741091013362 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 741091013363 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 741091013364 dimer interface [polypeptide binding]; other site 741091013365 active site 741091013366 FMN reductase; Validated; Region: fre; PRK08051 741091013367 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 741091013368 FAD binding pocket [chemical binding]; other site 741091013369 FAD binding motif [chemical binding]; other site 741091013370 phosphate binding motif [ion binding]; other site 741091013371 beta-alpha-beta structure motif; other site 741091013372 NAD binding pocket [chemical binding]; other site 741091013373 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 741091013374 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 741091013375 active site pocket [active] 741091013376 oxyanion hole [active] 741091013377 catalytic triad [active] 741091013378 active site nucleophile [active] 741091013379 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 741091013380 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 741091013381 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 741091013382 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 741091013383 active site 741091013384 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 741091013385 sec-independent translocase; Provisional; Region: PRK01770 741091013386 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 741091013387 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 741091013388 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 741091013389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 741091013390 SCP-2 sterol transfer family; Region: SCP2; pfam02036 741091013391 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 741091013392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091013393 S-adenosylmethionine binding site [chemical binding]; other site 741091013394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 741091013395 DNA recombination protein RmuC; Provisional; Region: PRK10361 741091013396 RmuC family; Region: RmuC; pfam02646 741091013397 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 741091013398 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 741091013399 uridine phosphorylase; Provisional; Region: PRK11178 741091013400 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 741091013401 hydroperoxidase II; Provisional; Region: katE; PRK11249 741091013402 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 741091013403 tetramer interface [polypeptide binding]; other site 741091013404 heme binding pocket [chemical binding]; other site 741091013405 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 741091013406 domain interactions; other site 741091013407 Dienelactone hydrolase family; Region: DLH; pfam01738 741091013408 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 741091013409 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 741091013410 active site 741091013411 intersubunit interactions; other site 741091013412 catalytic residue [active] 741091013413 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 741091013414 dimerization domain swap beta strand [polypeptide binding]; other site 741091013415 regulatory protein interface [polypeptide binding]; other site 741091013416 active site 741091013417 regulatory phosphorylation site [posttranslational modification]; other site 741091013418 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 741091013419 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 741091013420 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 741091013421 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 741091013422 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 741091013423 active site 741091013424 phosphorylation site [posttranslational modification] 741091013425 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 741091013426 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 741091013427 active site 741091013428 P-loop; other site 741091013429 phosphorylation site [posttranslational modification] 741091013430 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 741091013431 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 741091013432 dimer interface [polypeptide binding]; other site 741091013433 active site 741091013434 glycine loop; other site 741091013435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091013436 FeS/SAM binding site; other site 741091013437 pyruvate formate lyase II activase; Provisional; Region: PRK10076 741091013438 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 741091013439 active site 741091013440 P-loop; other site 741091013441 phosphorylation site [posttranslational modification] 741091013442 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 741091013443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091013444 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 741091013445 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 741091013446 THF binding site; other site 741091013447 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 741091013448 substrate binding site [chemical binding]; other site 741091013449 THF binding site; other site 741091013450 zinc-binding site [ion binding]; other site 741091013451 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 741091013452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091013453 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 741091013454 putative dimerization interface [polypeptide binding]; other site 741091013455 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 741091013456 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 741091013457 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 741091013458 putative active site [active] 741091013459 catalytic site [active] 741091013460 putative metal binding site [ion binding]; other site 741091013461 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 741091013462 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 741091013463 Walker A/P-loop; other site 741091013464 ATP binding site [chemical binding]; other site 741091013465 Q-loop/lid; other site 741091013466 ABC transporter signature motif; other site 741091013467 Walker B; other site 741091013468 D-loop; other site 741091013469 H-loop/switch region; other site 741091013470 TOBE domain; Region: TOBE_2; pfam08402 741091013471 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741091013472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091013473 dimer interface [polypeptide binding]; other site 741091013474 conserved gate region; other site 741091013475 putative PBP binding loops; other site 741091013476 ABC-ATPase subunit interface; other site 741091013477 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 741091013478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091013479 dimer interface [polypeptide binding]; other site 741091013480 conserved gate region; other site 741091013481 putative PBP binding loops; other site 741091013482 ABC-ATPase subunit interface; other site 741091013483 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 741091013484 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 741091013485 Protein of unknown function (DUF796); Region: DUF796; cl01226 741091013486 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 741091013487 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091013488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091013489 homodimer interface [polypeptide binding]; other site 741091013490 catalytic residue [active] 741091013491 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 741091013492 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 741091013493 Walker A/P-loop; other site 741091013494 ATP binding site [chemical binding]; other site 741091013495 Q-loop/lid; other site 741091013496 ABC transporter signature motif; other site 741091013497 Walker B; other site 741091013498 D-loop; other site 741091013499 H-loop/switch region; other site 741091013500 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 741091013501 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 741091013502 Walker A/P-loop; other site 741091013503 ATP binding site [chemical binding]; other site 741091013504 Q-loop/lid; other site 741091013505 ABC transporter signature motif; other site 741091013506 Walker B; other site 741091013507 D-loop; other site 741091013508 H-loop/switch region; other site 741091013509 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 741091013510 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 741091013511 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 741091013512 TM-ABC transporter signature motif; other site 741091013513 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091013514 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 741091013515 TM-ABC transporter signature motif; other site 741091013516 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 741091013517 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 741091013518 dimerization interface [polypeptide binding]; other site 741091013519 ligand binding site [chemical binding]; other site 741091013520 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 741091013521 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 741091013522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 741091013523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 741091013524 DNA binding residues [nucleotide binding] 741091013525 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 741091013526 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 741091013527 cell division protein FtsE; Provisional; Region: PRK10908 741091013528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091013529 Walker A/P-loop; other site 741091013530 ATP binding site [chemical binding]; other site 741091013531 Q-loop/lid; other site 741091013532 ABC transporter signature motif; other site 741091013533 Walker B; other site 741091013534 D-loop; other site 741091013535 H-loop/switch region; other site 741091013536 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 741091013537 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 741091013538 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 741091013539 P loop; other site 741091013540 GTP binding site [chemical binding]; other site 741091013541 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 741091013542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091013543 S-adenosylmethionine binding site [chemical binding]; other site 741091013544 hypothetical protein; Provisional; Region: PRK10910 741091013545 Predicted membrane protein [Function unknown]; Region: COG3714 741091013546 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 741091013547 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 741091013548 metal-binding site [ion binding] 741091013549 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 741091013550 Soluble P-type ATPase [General function prediction only]; Region: COG4087 741091013551 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 741091013552 CPxP motif; other site 741091013553 hypothetical protein; Provisional; Region: PRK11212 741091013554 hypothetical protein; Provisional; Region: PRK11615 741091013555 Protein of unknown function (DUF796); Region: DUF796; cl01226 741091013556 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 741091013557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091013558 putative substrate translocation pore; other site 741091013559 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 741091013560 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 741091013561 Walker A/P-loop; other site 741091013562 ATP binding site [chemical binding]; other site 741091013563 Q-loop/lid; other site 741091013564 ABC transporter signature motif; other site 741091013565 Walker B; other site 741091013566 D-loop; other site 741091013567 H-loop/switch region; other site 741091013568 phosphomannomutase CpsG; Provisional; Region: PRK15414 741091013569 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 741091013570 active site 741091013571 substrate binding site [chemical binding]; other site 741091013572 metal binding site [ion binding]; metal-binding site 741091013573 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741091013574 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091013575 DNA binding site [nucleotide binding] 741091013576 domain linker motif; other site 741091013577 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 741091013578 putative dimerization interface [polypeptide binding]; other site 741091013579 putative ligand binding site [chemical binding]; other site 741091013580 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 741091013581 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 741091013582 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 741091013583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091013584 dimer interface [polypeptide binding]; other site 741091013585 putative PBP binding loops; other site 741091013586 ABC-ATPase subunit interface; other site 741091013587 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 741091013588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091013589 dimer interface [polypeptide binding]; other site 741091013590 conserved gate region; other site 741091013591 putative PBP binding loops; other site 741091013592 ABC-ATPase subunit interface; other site 741091013593 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 741091013594 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 741091013595 active site 741091013596 catalytic site [active] 741091013597 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 741091013598 active site 741091013599 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 741091013600 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 741091013601 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 741091013602 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 741091013603 haemagglutination activity domain; Region: Haemagg_act; pfam05860 741091013604 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 741091013605 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 741091013606 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 741091013607 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 741091013608 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 741091013609 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 741091013610 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091013611 non-specific DNA binding site [nucleotide binding]; other site 741091013612 salt bridge; other site 741091013613 sequence-specific DNA binding site [nucleotide binding]; other site 741091013614 putative hydrolase; Provisional; Region: PRK10976 741091013615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091013616 active site 741091013617 motif I; other site 741091013618 motif II; other site 741091013619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091013620 lysophospholipase L2; Provisional; Region: PRK10749 741091013621 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741091013622 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 741091013623 threonine efflux system; Provisional; Region: PRK10229 741091013624 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 741091013625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741091013626 ATP binding site [chemical binding]; other site 741091013627 putative Mg++ binding site [ion binding]; other site 741091013628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091013629 nucleotide binding region [chemical binding]; other site 741091013630 ATP-binding site [chemical binding]; other site 741091013631 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 741091013632 HRDC domain; Region: HRDC; pfam00570 741091013633 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 741091013634 dimerization interface [polypeptide binding]; other site 741091013635 substrate binding site [chemical binding]; other site 741091013636 active site 741091013637 calcium binding site [ion binding]; other site 741091013638 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 741091013639 CoenzymeA binding site [chemical binding]; other site 741091013640 subunit interaction site [polypeptide binding]; other site 741091013641 PHB binding site; other site 741091013642 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 741091013643 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 741091013644 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 741091013645 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 741091013646 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 741091013647 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 741091013648 Cl binding site [ion binding]; other site 741091013649 oligomer interface [polypeptide binding]; other site 741091013650 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 741091013651 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 741091013652 Part of AAA domain; Region: AAA_19; pfam13245 741091013653 Family description; Region: UvrD_C_2; pfam13538 741091013654 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 741091013655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091013656 motif II; other site 741091013657 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 741091013658 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 741091013659 active site 741091013660 Int/Topo IB signature motif; other site 741091013661 hypothetical protein; Provisional; Region: PRK10963 741091013662 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 741091013663 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 741091013664 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 741091013665 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 741091013666 adenylate cyclase; Provisional; Region: cyaA; PRK09450 741091013667 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 741091013668 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 741091013669 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 741091013670 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 741091013671 domain interfaces; other site 741091013672 active site 741091013673 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 741091013674 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 741091013675 active site 741091013676 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 741091013677 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 741091013678 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 741091013679 HemY protein N-terminus; Region: HemY_N; pfam07219 741091013680 putative transport protein YifK; Provisional; Region: PRK10746 741091013681 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 741091013682 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 741091013683 putative common antigen polymerase; Provisional; Region: PRK02975 741091013684 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 741091013685 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 741091013686 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 741091013687 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 741091013688 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 741091013689 inhibitor-cofactor binding pocket; inhibition site 741091013690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091013691 catalytic residue [active] 741091013692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091013693 Coenzyme A binding pocket [chemical binding]; other site 741091013694 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 741091013695 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 741091013696 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 741091013697 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 741091013698 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 741091013699 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 741091013700 active site 741091013701 homodimer interface [polypeptide binding]; other site 741091013702 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 741091013703 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 741091013704 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 741091013705 Mg++ binding site [ion binding]; other site 741091013706 putative catalytic motif [active] 741091013707 substrate binding site [chemical binding]; other site 741091013708 transcription termination factor Rho; Provisional; Region: rho; PRK09376 741091013709 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 741091013710 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 741091013711 RNA binding site [nucleotide binding]; other site 741091013712 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 741091013713 multimer interface [polypeptide binding]; other site 741091013714 Walker A motif; other site 741091013715 ATP binding site [chemical binding]; other site 741091013716 Walker B motif; other site 741091013717 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 741091013718 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 741091013719 catalytic residues [active] 741091013720 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 741091013721 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 741091013722 ATP binding site [chemical binding]; other site 741091013723 Mg++ binding site [ion binding]; other site 741091013724 motif III; other site 741091013725 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091013726 nucleotide binding region [chemical binding]; other site 741091013727 ATP-binding site [chemical binding]; other site 741091013728 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 741091013729 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 741091013730 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 741091013731 Part of AAA domain; Region: AAA_19; pfam13245 741091013732 Family description; Region: UvrD_C_2; pfam13538 741091013733 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 741091013734 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 741091013735 ketol-acid reductoisomerase; Validated; Region: PRK05225 741091013736 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 741091013737 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 741091013738 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 741091013739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091013740 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 741091013741 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 741091013742 putative dimerization interface [polypeptide binding]; other site 741091013743 threonine dehydratase; Reviewed; Region: PRK09224 741091013744 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 741091013745 tetramer interface [polypeptide binding]; other site 741091013746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091013747 catalytic residue [active] 741091013748 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 741091013749 putative Ile/Val binding site [chemical binding]; other site 741091013750 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 741091013751 putative Ile/Val binding site [chemical binding]; other site 741091013752 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 741091013753 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 741091013754 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 741091013755 homodimer interface [polypeptide binding]; other site 741091013756 substrate-cofactor binding pocket; other site 741091013757 catalytic residue [active] 741091013758 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 741091013759 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 741091013760 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 741091013761 PYR/PP interface [polypeptide binding]; other site 741091013762 dimer interface [polypeptide binding]; other site 741091013763 TPP binding site [chemical binding]; other site 741091013764 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 741091013765 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 741091013766 TPP-binding site [chemical binding]; other site 741091013767 dimer interface [polypeptide binding]; other site 741091013768 putative sialic acid transporter; Region: 2A0112; TIGR00891 741091013769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091013770 putative substrate translocation pore; other site 741091013771 putative ATP-dependent protease; Provisional; Region: PRK09862 741091013772 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 741091013773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091013774 Walker A motif; other site 741091013775 ATP binding site [chemical binding]; other site 741091013776 Walker B motif; other site 741091013777 arginine finger; other site 741091013778 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 741091013779 hypothetical protein; Provisional; Region: PRK11027 741091013780 transcriptional regulator HdfR; Provisional; Region: PRK03601 741091013781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091013782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 741091013783 dimerization interface [polypeptide binding]; other site 741091013784 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091013785 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091013786 TM-ABC transporter signature motif; other site 741091013787 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091013788 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091013789 TM-ABC transporter signature motif; other site 741091013790 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 741091013791 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741091013792 Walker A/P-loop; other site 741091013793 ATP binding site [chemical binding]; other site 741091013794 Q-loop/lid; other site 741091013795 ABC transporter signature motif; other site 741091013796 Walker B; other site 741091013797 D-loop; other site 741091013798 H-loop/switch region; other site 741091013799 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741091013800 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 741091013801 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 741091013802 putative ligand binding site [chemical binding]; other site 741091013803 Transposase; Region: HTH_Tnp_1; pfam01527 741091013804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 741091013805 HTH-like domain; Region: HTH_21; pfam13276 741091013806 Integrase core domain; Region: rve; pfam00665 741091013807 Integrase core domain; Region: rve_3; pfam13683 741091013808 glutamate racemase; Provisional; Region: PRK00865 741091013809 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 741091013810 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741091013811 N-terminal plug; other site 741091013812 ligand-binding site [chemical binding]; other site 741091013813 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 741091013814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091013815 S-adenosylmethionine binding site [chemical binding]; other site 741091013816 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 741091013817 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 741091013818 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 741091013819 hypothetical protein; Provisional; Region: PRK11056 741091013820 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 741091013821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091013822 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 741091013823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 741091013824 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 741091013825 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 741091013826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091013827 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 741091013828 dimerization interface [polypeptide binding]; other site 741091013829 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 741091013830 catalytic triad [active] 741091013831 dimer interface [polypeptide binding]; other site 741091013832 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 741091013833 GSH binding site [chemical binding]; other site 741091013834 catalytic residues [active] 741091013835 argininosuccinate lyase; Provisional; Region: PRK04833 741091013836 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 741091013837 active sites [active] 741091013838 tetramer interface [polypeptide binding]; other site 741091013839 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 741091013840 nucleotide binding site [chemical binding]; other site 741091013841 N-acetyl-L-glutamate binding site [chemical binding]; other site 741091013842 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 741091013843 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 741091013844 acetylornithine deacetylase; Provisional; Region: PRK05111 741091013845 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 741091013846 metal binding site [ion binding]; metal-binding site 741091013847 putative dimer interface [polypeptide binding]; other site 741091013848 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 741091013849 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 741091013850 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 741091013851 FAD binding site [chemical binding]; other site 741091013852 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 741091013853 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 741091013854 putative catalytic residues [active] 741091013855 putative nucleotide binding site [chemical binding]; other site 741091013856 putative aspartate binding site [chemical binding]; other site 741091013857 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 741091013858 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 741091013859 cystathionine gamma-synthase; Provisional; Region: PRK08045 741091013860 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 741091013861 homodimer interface [polypeptide binding]; other site 741091013862 substrate-cofactor binding pocket; other site 741091013863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091013864 catalytic residue [active] 741091013865 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 741091013866 dimerization interface [polypeptide binding]; other site 741091013867 DNA binding site [nucleotide binding] 741091013868 corepressor binding sites; other site 741091013869 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 741091013870 primosome assembly protein PriA; Validated; Region: PRK05580 741091013871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741091013872 ATP binding site [chemical binding]; other site 741091013873 putative Mg++ binding site [ion binding]; other site 741091013874 helicase superfamily c-terminal domain; Region: HELICc; smart00490 741091013875 ATP-binding site [chemical binding]; other site 741091013876 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091013877 DNA binding site [nucleotide binding] 741091013878 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 741091013879 domain linker motif; other site 741091013880 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 741091013881 dimerization interface [polypeptide binding]; other site 741091013882 ligand binding site [chemical binding]; other site 741091013883 cell division protein FtsN; Provisional; Region: PRK12757 741091013884 Sporulation related domain; Region: SPOR; cl10051 741091013885 Sporulation related domain; Region: SPOR; cl10051 741091013886 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 741091013887 active site 741091013888 HslU subunit interaction site [polypeptide binding]; other site 741091013889 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 741091013890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091013891 Walker A motif; other site 741091013892 ATP binding site [chemical binding]; other site 741091013893 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 741091013894 Walker B motif; other site 741091013895 arginine finger; other site 741091013896 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 741091013897 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 741091013898 UbiA prenyltransferase family; Region: UbiA; pfam01040 741091013899 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 741091013900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 741091013901 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 741091013902 amphipathic channel; other site 741091013903 Asn-Pro-Ala signature motifs; other site 741091013904 glycerol kinase; Provisional; Region: glpK; PRK00047 741091013905 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 741091013906 N- and C-terminal domain interface [polypeptide binding]; other site 741091013907 active site 741091013908 MgATP binding site [chemical binding]; other site 741091013909 catalytic site [active] 741091013910 metal binding site [ion binding]; metal-binding site 741091013911 glycerol binding site [chemical binding]; other site 741091013912 homotetramer interface [polypeptide binding]; other site 741091013913 homodimer interface [polypeptide binding]; other site 741091013914 FBP binding site [chemical binding]; other site 741091013915 protein IIAGlc interface [polypeptide binding]; other site 741091013916 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 741091013917 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 741091013918 putative active site [active] 741091013919 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 741091013920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091013921 putative substrate translocation pore; other site 741091013922 ferredoxin-NADP reductase; Provisional; Region: PRK10926 741091013923 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 741091013924 FAD binding pocket [chemical binding]; other site 741091013925 FAD binding motif [chemical binding]; other site 741091013926 phosphate binding motif [ion binding]; other site 741091013927 beta-alpha-beta structure motif; other site 741091013928 NAD binding pocket [chemical binding]; other site 741091013929 Predicted membrane protein [Function unknown]; Region: COG3152 741091013930 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 741091013931 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 741091013932 triosephosphate isomerase; Provisional; Region: PRK14567 741091013933 substrate binding site [chemical binding]; other site 741091013934 dimer interface [polypeptide binding]; other site 741091013935 catalytic triad [active] 741091013936 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 741091013937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091013938 substrate binding pocket [chemical binding]; other site 741091013939 membrane-bound complex binding site; other site 741091013940 6-phosphofructokinase; Provisional; Region: PRK03202 741091013941 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 741091013942 active site 741091013943 ADP/pyrophosphate binding site [chemical binding]; other site 741091013944 dimerization interface [polypeptide binding]; other site 741091013945 allosteric effector site; other site 741091013946 fructose-1,6-bisphosphate binding site; other site 741091013947 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 741091013948 dimer interface [polypeptide binding]; other site 741091013949 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 741091013950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091013951 active site 741091013952 phosphorylation site [posttranslational modification] 741091013953 intermolecular recognition site; other site 741091013954 dimerization interface [polypeptide binding]; other site 741091013955 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091013956 DNA binding site [nucleotide binding] 741091013957 two-component sensor protein; Provisional; Region: cpxA; PRK09470 741091013958 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 741091013959 dimerization interface [polypeptide binding]; other site 741091013960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091013961 dimer interface [polypeptide binding]; other site 741091013962 phosphorylation site [posttranslational modification] 741091013963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091013964 ATP binding site [chemical binding]; other site 741091013965 Mg2+ binding site [ion binding]; other site 741091013966 G-X-G motif; other site 741091013967 putative rRNA methylase; Provisional; Region: PRK10358 741091013968 serine acetyltransferase; Provisional; Region: cysE; PRK11132 741091013969 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 741091013970 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 741091013971 trimer interface [polypeptide binding]; other site 741091013972 active site 741091013973 substrate binding site [chemical binding]; other site 741091013974 CoA binding site [chemical binding]; other site 741091013975 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 741091013976 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 741091013977 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 741091013978 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 741091013979 SecA binding site; other site 741091013980 Preprotein binding site; other site 741091013981 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 741091013982 GSH binding site [chemical binding]; other site 741091013983 catalytic residues [active] 741091013984 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 741091013985 active site residue [active] 741091013986 phosphoglyceromutase; Provisional; Region: PRK05434 741091013987 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 741091013988 AmiB activator; Provisional; Region: PRK11637 741091013989 Peptidase family M23; Region: Peptidase_M23; pfam01551 741091013990 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 741091013991 NodB motif; other site 741091013992 putative active site [active] 741091013993 putative catalytic site [active] 741091013994 Zn binding site [ion binding]; other site 741091013995 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 741091013996 putative ADP-binding pocket [chemical binding]; other site 741091013997 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 741091013998 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 741091013999 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 741091014000 NAD(P) binding site [chemical binding]; other site 741091014001 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 741091014002 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 741091014003 substrate-cofactor binding pocket; other site 741091014004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091014005 catalytic residue [active] 741091014006 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 741091014007 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 741091014008 NADP binding site [chemical binding]; other site 741091014009 homopentamer interface [polypeptide binding]; other site 741091014010 substrate binding site [chemical binding]; other site 741091014011 active site 741091014012 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 741091014013 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 741091014014 putative active site [active] 741091014015 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 741091014016 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 741091014017 putative active site [active] 741091014018 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 741091014019 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 741091014020 putative active site [active] 741091014021 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 741091014022 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 741091014023 Ligand binding site; other site 741091014024 metal-binding site 741091014025 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 741091014026 O-Antigen ligase; Region: Wzy_C; pfam04932 741091014027 putative glycosyl transferase; Provisional; Region: PRK10073 741091014028 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 741091014029 active site 741091014030 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 741091014031 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 741091014032 putative active site [active] 741091014033 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 741091014034 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 741091014035 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 741091014036 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 741091014037 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 741091014038 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 741091014039 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 741091014040 putative metal binding site; other site 741091014041 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 741091014042 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 741091014043 active site 741091014044 (T/H)XGH motif; other site 741091014045 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 741091014046 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 741091014047 DNA binding site [nucleotide binding] 741091014048 catalytic residue [active] 741091014049 H2TH interface [polypeptide binding]; other site 741091014050 putative catalytic residues [active] 741091014051 turnover-facilitating residue; other site 741091014052 intercalation triad [nucleotide binding]; other site 741091014053 8OG recognition residue [nucleotide binding]; other site 741091014054 putative reading head residues; other site 741091014055 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 741091014056 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 741091014057 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 741091014058 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 741091014059 hypothetical protein; Reviewed; Region: PRK00024 741091014060 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 741091014061 MPN+ (JAMM) motif; other site 741091014062 Zinc-binding site [ion binding]; other site 741091014063 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 741091014064 Flavoprotein; Region: Flavoprotein; pfam02441 741091014065 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 741091014066 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 741091014067 trimer interface [polypeptide binding]; other site 741091014068 active site 741091014069 division inhibitor protein; Provisional; Region: slmA; PRK09480 741091014070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091014071 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 741091014072 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 741091014073 Predicted membrane protein [Function unknown]; Region: COG4984 741091014074 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 741091014075 active site 741091014076 ribonuclease PH; Reviewed; Region: rph; PRK00173 741091014077 Ribonuclease PH; Region: RNase_PH_bact; cd11362 741091014078 hexamer interface [polypeptide binding]; other site 741091014079 active site 741091014080 hypothetical protein; Provisional; Region: PRK11820 741091014081 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 741091014082 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 741091014083 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 741091014084 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 741091014085 dimer interface [polypeptide binding]; other site 741091014086 active site 741091014087 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091014088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091014089 Predicted membrane protein [Function unknown]; Region: COG2860 741091014090 UPF0126 domain; Region: UPF0126; pfam03458 741091014091 UPF0126 domain; Region: UPF0126; pfam03458 741091014092 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 741091014093 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 741091014094 nucleotide binding pocket [chemical binding]; other site 741091014095 K-X-D-G motif; other site 741091014096 catalytic site [active] 741091014097 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 741091014098 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 741091014099 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 741091014100 catalytic site [active] 741091014101 G-X2-G-X-G-K; other site 741091014102 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 741091014103 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 741091014104 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 741091014105 Zn2+ binding site [ion binding]; other site 741091014106 Mg2+ binding site [ion binding]; other site 741091014107 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 741091014108 synthetase active site [active] 741091014109 NTP binding site [chemical binding]; other site 741091014110 metal binding site [ion binding]; metal-binding site 741091014111 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 741091014112 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 741091014113 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 741091014114 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 741091014115 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 741091014116 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 741091014117 Y-family of DNA polymerases; Region: PolY; cl12025 741091014118 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 741091014119 generic binding surface II; other site 741091014120 ssDNA binding site; other site 741091014121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 741091014122 ATP binding site [chemical binding]; other site 741091014123 putative Mg++ binding site [ion binding]; other site 741091014124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 741091014125 nucleotide binding region [chemical binding]; other site 741091014126 ATP-binding site [chemical binding]; other site 741091014127 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 741091014128 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 741091014129 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 741091014130 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 741091014131 AsmA family; Region: AsmA; pfam05170 741091014132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091014133 Coenzyme A binding pocket [chemical binding]; other site 741091014134 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 741091014135 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 741091014136 putative active site [active] 741091014137 dimerization interface [polypeptide binding]; other site 741091014138 putative tRNAtyr binding site [nucleotide binding]; other site 741091014139 hypothetical protein; Reviewed; Region: PRK01637 741091014140 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 741091014141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091014142 motif II; other site 741091014143 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 741091014144 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 741091014145 G1 box; other site 741091014146 putative GEF interaction site [polypeptide binding]; other site 741091014147 GTP/Mg2+ binding site [chemical binding]; other site 741091014148 Switch I region; other site 741091014149 G2 box; other site 741091014150 G3 box; other site 741091014151 Switch II region; other site 741091014152 G4 box; other site 741091014153 G5 box; other site 741091014154 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 741091014155 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 741091014156 glutamine synthetase; Provisional; Region: glnA; PRK09469 741091014157 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 741091014158 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 741091014159 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 741091014160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091014161 dimer interface [polypeptide binding]; other site 741091014162 phosphorylation site [posttranslational modification] 741091014163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091014164 ATP binding site [chemical binding]; other site 741091014165 Mg2+ binding site [ion binding]; other site 741091014166 G-X-G motif; other site 741091014167 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 741091014168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091014169 active site 741091014170 phosphorylation site [posttranslational modification] 741091014171 intermolecular recognition site; other site 741091014172 dimerization interface [polypeptide binding]; other site 741091014173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091014174 Walker A motif; other site 741091014175 ATP binding site [chemical binding]; other site 741091014176 Walker B motif; other site 741091014177 arginine finger; other site 741091014178 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 741091014179 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 741091014180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091014181 FeS/SAM binding site; other site 741091014182 HemN C-terminal domain; Region: HemN_C; pfam06969 741091014183 Der GTPase activator; Provisional; Region: PRK05244 741091014184 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 741091014185 G1 box; other site 741091014186 GTP/Mg2+ binding site [chemical binding]; other site 741091014187 Switch I region; other site 741091014188 G2 box; other site 741091014189 G3 box; other site 741091014190 Switch II region; other site 741091014191 G4 box; other site 741091014192 G5 box; other site 741091014193 DNA polymerase I; Provisional; Region: PRK05755 741091014194 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 741091014195 active site 741091014196 metal binding site 1 [ion binding]; metal-binding site 741091014197 putative 5' ssDNA interaction site; other site 741091014198 metal binding site 3; metal-binding site 741091014199 metal binding site 2 [ion binding]; metal-binding site 741091014200 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 741091014201 putative DNA binding site [nucleotide binding]; other site 741091014202 putative metal binding site [ion binding]; other site 741091014203 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 741091014204 active site 741091014205 catalytic site [active] 741091014206 substrate binding site [chemical binding]; other site 741091014207 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 741091014208 active site 741091014209 DNA binding site [nucleotide binding] 741091014210 catalytic site [active] 741091014211 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 741091014212 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 741091014213 catalytic residues [active] 741091014214 hinge region; other site 741091014215 alpha helical domain; other site 741091014216 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 741091014217 serine/threonine protein kinase; Provisional; Region: PRK11768 741091014218 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 741091014219 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 741091014220 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 741091014221 GTP binding site; other site 741091014222 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 741091014223 Walker A motif; other site 741091014224 Transcriptional regulators [Transcription]; Region: FadR; COG2186 741091014225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091014226 DNA-binding site [nucleotide binding]; DNA binding site 741091014227 FCD domain; Region: FCD; pfam07729 741091014228 transcriptional repressor RbsR; Provisional; Region: PRK10423 741091014229 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091014230 DNA binding site [nucleotide binding] 741091014231 domain linker motif; other site 741091014232 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 741091014233 dimerization interface [polypeptide binding]; other site 741091014234 ligand binding site [chemical binding]; other site 741091014235 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741091014236 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 741091014237 substrate binding site [chemical binding]; other site 741091014238 dimer interface [polypeptide binding]; other site 741091014239 ATP binding site [chemical binding]; other site 741091014240 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 741091014241 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 741091014242 ligand binding site [chemical binding]; other site 741091014243 dimerization interface [polypeptide binding]; other site 741091014244 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091014245 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091014246 TM-ABC transporter signature motif; other site 741091014247 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 741091014248 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741091014249 Walker A/P-loop; other site 741091014250 ATP binding site [chemical binding]; other site 741091014251 Q-loop/lid; other site 741091014252 ABC transporter signature motif; other site 741091014253 Walker B; other site 741091014254 D-loop; other site 741091014255 H-loop/switch region; other site 741091014256 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741091014257 D-ribose pyranase; Provisional; Region: PRK11797 741091014258 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 741091014259 potassium uptake protein; Region: kup; TIGR00794 741091014260 regulatory ATPase RavA; Provisional; Region: PRK13531 741091014261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091014262 Walker A motif; other site 741091014263 ATP binding site [chemical binding]; other site 741091014264 Walker B motif; other site 741091014265 arginine finger; other site 741091014266 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 741091014267 hypothetical protein; Provisional; Region: yieM; PRK10997 741091014268 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 741091014269 metal ion-dependent adhesion site (MIDAS); other site 741091014270 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 741091014271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091014272 putative DNA binding site [nucleotide binding]; other site 741091014273 putative Zn2+ binding site [ion binding]; other site 741091014274 AsnC family; Region: AsnC_trans_reg; pfam01037 741091014275 FMN-binding protein MioC; Provisional; Region: PRK09004 741091014276 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 741091014277 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 741091014278 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 741091014279 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 741091014280 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 741091014281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091014282 S-adenosylmethionine binding site [chemical binding]; other site 741091014283 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 741091014284 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 741091014285 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 741091014286 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 741091014287 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 741091014288 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 741091014289 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 741091014290 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 741091014291 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 741091014292 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 741091014293 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 741091014294 beta subunit interaction interface [polypeptide binding]; other site 741091014295 Walker A motif; other site 741091014296 ATP binding site [chemical binding]; other site 741091014297 Walker B motif; other site 741091014298 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 741091014299 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 741091014300 core domain interface [polypeptide binding]; other site 741091014301 delta subunit interface [polypeptide binding]; other site 741091014302 epsilon subunit interface [polypeptide binding]; other site 741091014303 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 741091014304 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 741091014305 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 741091014306 alpha subunit interaction interface [polypeptide binding]; other site 741091014307 Walker A motif; other site 741091014308 ATP binding site [chemical binding]; other site 741091014309 Walker B motif; other site 741091014310 inhibitor binding site; inhibition site 741091014311 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 741091014312 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 741091014313 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 741091014314 gamma subunit interface [polypeptide binding]; other site 741091014315 epsilon subunit interface [polypeptide binding]; other site 741091014316 LBP interface [polypeptide binding]; other site 741091014317 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 741091014318 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 741091014319 Substrate binding site; other site 741091014320 Mg++ binding site; other site 741091014321 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 741091014322 active site 741091014323 substrate binding site [chemical binding]; other site 741091014324 CoA binding site [chemical binding]; other site 741091014325 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 741091014326 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 741091014327 glutaminase active site [active] 741091014328 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 741091014329 dimer interface [polypeptide binding]; other site 741091014330 active site 741091014331 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 741091014332 dimer interface [polypeptide binding]; other site 741091014333 active site 741091014334 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 741091014335 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 741091014336 RNA binding surface [nucleotide binding]; other site 741091014337 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 741091014338 probable active site [active] 741091014339 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 741091014340 substrate binding pocket [chemical binding]; other site 741091014341 membrane-bound complex binding site; other site 741091014342 hinge residues; other site 741091014343 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 741091014344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091014345 dimer interface [polypeptide binding]; other site 741091014346 conserved gate region; other site 741091014347 putative PBP binding loops; other site 741091014348 ABC-ATPase subunit interface; other site 741091014349 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 741091014350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091014351 dimer interface [polypeptide binding]; other site 741091014352 conserved gate region; other site 741091014353 putative PBP binding loops; other site 741091014354 ABC-ATPase subunit interface; other site 741091014355 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 741091014356 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 741091014357 Walker A/P-loop; other site 741091014358 ATP binding site [chemical binding]; other site 741091014359 Q-loop/lid; other site 741091014360 ABC transporter signature motif; other site 741091014361 Walker B; other site 741091014362 D-loop; other site 741091014363 H-loop/switch region; other site 741091014364 transcriptional regulator PhoU; Provisional; Region: PRK11115 741091014365 PhoU domain; Region: PhoU; pfam01895 741091014366 PhoU domain; Region: PhoU; pfam01895 741091014367 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 741091014368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091014369 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 741091014370 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 741091014371 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 741091014372 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 741091014373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091014374 motif II; other site 741091014375 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 741091014376 Predicted flavoprotein [General function prediction only]; Region: COG0431 741091014377 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 741091014378 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 741091014379 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 741091014380 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091014381 dimer interface [polypeptide binding]; other site 741091014382 putative CheW interface [polypeptide binding]; other site 741091014383 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091014384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091014385 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 741091014386 putative effector binding pocket; other site 741091014387 putative dimerization interface [polypeptide binding]; other site 741091014388 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 741091014389 putative NAD(P) binding site [chemical binding]; other site 741091014390 homodimer interface [polypeptide binding]; other site 741091014391 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 741091014392 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 741091014393 trmE is a tRNA modification GTPase; Region: trmE; cd04164 741091014394 G1 box; other site 741091014395 GTP/Mg2+ binding site [chemical binding]; other site 741091014396 Switch I region; other site 741091014397 G2 box; other site 741091014398 Switch II region; other site 741091014399 G3 box; other site 741091014400 G4 box; other site 741091014401 G5 box; other site 741091014402 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 741091014403 membrane protein insertase; Provisional; Region: PRK01318 741091014404 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 741091014405 hypothetical protein; Validated; Region: PRK00041 741091014406 ribonuclease P; Reviewed; Region: rnpA; PRK01732 741091014407 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 741091014408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 741091014409 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 741091014410 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 741091014411 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741091014412 N-terminal plug; other site 741091014413 ligand-binding site [chemical binding]; other site 741091014414 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 741091014415 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 741091014416 active site 741091014417 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 741091014418 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 741091014419 ligand binding site [chemical binding]; other site 741091014420 flexible hinge region; other site 741091014421 YebG protein; Region: YebG; pfam07130 741091014422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091014423 Coenzyme A binding pocket [chemical binding]; other site 741091014424 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091014425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091014426 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 741091014427 dimerization interface [polypeptide binding]; other site 741091014428 substrate binding pocket [chemical binding]; other site 741091014429 Predicted amidohydrolase [General function prediction only]; Region: COG0388 741091014430 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 741091014431 putative active site [active] 741091014432 catalytic triad [active] 741091014433 putative dimer interface [polypeptide binding]; other site 741091014434 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 741091014435 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 741091014436 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 741091014437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091014438 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091014439 dimerization interface [polypeptide binding]; other site 741091014440 trehalase; Provisional; Region: treF; PRK13270 741091014441 Trehalase; Region: Trehalase; cl17346 741091014442 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 741091014443 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 741091014444 active site 741091014445 homotetramer interface [polypeptide binding]; other site 741091014446 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 741091014447 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 741091014448 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 741091014449 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 741091014450 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 741091014451 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 741091014452 PhoU domain; Region: PhoU; pfam01895 741091014453 PhoU domain; Region: PhoU; pfam01895 741091014454 magnesium-transporting ATPase; Provisional; Region: PRK15122 741091014455 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 741091014456 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 741091014457 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 741091014458 Soluble P-type ATPase [General function prediction only]; Region: COG4087 741091014459 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 741091014460 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 741091014461 Right handed beta helix region; Region: Beta_helix; pfam13229 741091014462 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 741091014463 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 741091014464 Protein of unknown function (DUF535); Region: DUF535; pfam04393 741091014465 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 741091014466 active site 741091014467 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 741091014468 Protein of unknown function (DUF796); Region: DUF796; cl01226 741091014469 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 741091014470 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 741091014471 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 741091014472 putative active site [active] 741091014473 metal binding site [ion binding]; metal-binding site 741091014474 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 741091014475 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 741091014476 putative ligand binding site [chemical binding]; other site 741091014477 Uncharacterized conserved protein [Function unknown]; Region: COG5276 741091014478 EamA-like transporter family; Region: EamA; cl17759 741091014479 EamA-like transporter family; Region: EamA; pfam00892 741091014480 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 741091014481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091014482 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741091014483 putative substrate translocation pore; other site 741091014484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091014485 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 741091014486 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 741091014487 inhibitor site; inhibition site 741091014488 active site 741091014489 dimer interface [polypeptide binding]; other site 741091014490 catalytic residue [active] 741091014491 Virulence factor SrfB; Region: SrfB; pfam07520 741091014492 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 741091014493 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 741091014494 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 741091014495 putative active site; other site 741091014496 catalytic residue [active] 741091014497 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 741091014498 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 741091014499 potential catalytic triad [active] 741091014500 conserved cys residue [active] 741091014501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091014502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091014503 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 741091014504 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 741091014505 nucleotide binding site [chemical binding]; other site 741091014506 putative NEF/HSP70 interaction site [polypeptide binding]; other site 741091014507 SBD interface [polypeptide binding]; other site 741091014508 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 741091014509 HSP70 interaction site [polypeptide binding]; other site 741091014510 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 741091014511 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 741091014512 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 741091014513 active site 741091014514 Na/Ca binding site [ion binding]; other site 741091014515 catalytic site [active] 741091014516 proline/glycine betaine transporter; Provisional; Region: PRK10642 741091014517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091014518 putative substrate translocation pore; other site 741091014519 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 741091014520 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 741091014521 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 741091014522 hypothetical protein; Provisional; Region: PRK09273 741091014523 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 741091014524 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 741091014525 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 741091014526 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 741091014527 NADP binding site [chemical binding]; other site 741091014528 homodimer interface [polypeptide binding]; other site 741091014529 active site 741091014530 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 741091014531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091014532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091014533 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 741091014534 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091014535 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 741091014536 Predicted transcriptional regulator [Transcription]; Region: COG1959 741091014537 Transcriptional regulator; Region: Rrf2; pfam02082 741091014538 HipA-like N-terminal domain; Region: HipA_N; pfam07805 741091014539 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 741091014540 variable surface protein Vir12; Provisional; Region: PTZ00234 741091014541 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 741091014542 Phage-related protein, tail component [Function unknown]; Region: COG4733 741091014543 Putative phage tail protein; Region: Phage-tail_3; pfam13550 741091014544 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 741091014545 Interdomain contacts; other site 741091014546 Cytokine receptor motif; other site 741091014547 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 741091014548 Phage-related protein, tail component [Function unknown]; Region: COG4723 741091014549 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 741091014550 MPN+ (JAMM) motif; other site 741091014551 Zinc-binding site [ion binding]; other site 741091014552 NlpC/P60 family; Region: NLPC_P60; pfam00877 741091014553 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 741091014554 Phage minor tail protein L; Region: Phage_tail_L; cl01908 741091014555 Phage minor tail protein L; Region: Phage_tail_L; cl01908 741091014556 Phage minor tail protein; Region: Phage_min_tail; pfam05939 741091014557 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 741091014558 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 741091014559 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 741091014560 Minor tail protein T; Region: Phage_tail_T; cl05636 741091014561 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 741091014562 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 741091014563 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 741091014564 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 741091014565 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 741091014566 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 741091014567 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 741091014568 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 741091014569 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 741091014570 oligomer interface [polypeptide binding]; other site 741091014571 active site residues [active] 741091014572 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 741091014573 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 741091014574 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 741091014575 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 741091014576 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 741091014577 anti-adapter protein IraM; Provisional; Region: PRK09919 741091014578 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 741091014579 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741091014580 catalytic residues [active] 741091014581 Lysis protein S; Region: Lysis_S; pfam04971 741091014582 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 741091014583 DNA methylase; Region: N6_N4_Mtase; pfam01555 741091014584 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 741091014585 DNA methylase; Region: N6_N4_Mtase; pfam01555 741091014586 Antitermination protein; Region: Antiterm; pfam03589 741091014587 Antitermination protein; Region: Antiterm; pfam03589 741091014588 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 741091014589 active site 741091014590 MT-A70; Region: MT-A70; cl01947 741091014591 Helix-turn-helix domain; Region: HTH_36; pfam13730 741091014592 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 741091014593 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 741091014594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091014595 non-specific DNA binding site [nucleotide binding]; other site 741091014596 salt bridge; other site 741091014597 sequence-specific DNA binding site [nucleotide binding]; other site 741091014598 Predicted transcriptional regulator [Transcription]; Region: COG2932 741091014599 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 741091014600 Catalytic site [active] 741091014601 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 741091014602 HicB family; Region: HicB; pfam05534 741091014603 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 741091014604 Excisionase-like protein; Region: Exc; pfam07825 741091014605 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 741091014606 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741091014607 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 741091014608 dimer interface [polypeptide binding]; other site 741091014609 active site 741091014610 Int/Topo IB signature motif; other site 741091014611 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 741091014612 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 741091014613 trimer interface [polypeptide binding]; other site 741091014614 eyelet of channel; other site 741091014615 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 741091014616 acetoin reductase; Validated; Region: PRK08643 741091014617 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 741091014618 NAD binding site [chemical binding]; other site 741091014619 homotetramer interface [polypeptide binding]; other site 741091014620 homodimer interface [polypeptide binding]; other site 741091014621 active site 741091014622 substrate binding site [chemical binding]; other site 741091014623 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 741091014624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091014625 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 741091014626 Tannase and feruloyl esterase; Region: Tannase; pfam07519 741091014627 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 741091014628 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 741091014629 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 741091014630 Methyltransferase domain; Region: Methyltransf_31; pfam13847 741091014631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091014632 S-adenosylmethionine binding site [chemical binding]; other site 741091014633 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741091014634 active site 741091014635 DNA binding site [nucleotide binding] 741091014636 Int/Topo IB signature motif; other site 741091014637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 741091014638 PAS domain; Region: PAS_9; pfam13426 741091014639 putative active site [active] 741091014640 heme pocket [chemical binding]; other site 741091014641 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 741091014642 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091014643 dimer interface [polypeptide binding]; other site 741091014644 putative CheW interface [polypeptide binding]; other site 741091014645 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 741091014646 ligand binding site [chemical binding]; other site 741091014647 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 741091014648 dimerization interface [polypeptide binding]; other site 741091014649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091014650 dimer interface [polypeptide binding]; other site 741091014651 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 741091014652 putative CheW interface [polypeptide binding]; other site 741091014653 Protein of unknown function (DUF770); Region: DUF770; pfam05591 741091014654 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 741091014655 Protein of unknown function (DUF877); Region: DUF877; pfam05943 741091014656 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 741091014657 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 741091014658 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 741091014659 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 741091014660 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 741091014661 ligand binding site [chemical binding]; other site 741091014662 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 741091014663 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 741091014664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091014665 Walker A motif; other site 741091014666 ATP binding site [chemical binding]; other site 741091014667 Walker B motif; other site 741091014668 arginine finger; other site 741091014669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091014670 Walker A motif; other site 741091014671 ATP binding site [chemical binding]; other site 741091014672 Walker B motif; other site 741091014673 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 741091014674 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 741091014675 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 741091014676 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 741091014677 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 741091014678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 741091014679 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 741091014680 PAAR motif; Region: PAAR_motif; pfam05488 741091014681 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 741091014682 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 741091014683 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 741091014684 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 741091014685 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 741091014686 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 741091014687 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 741091014688 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 741091014689 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 741091014690 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 741091014691 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 741091014692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 741091014693 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 741091014694 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 741091014695 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 741091014696 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 741091014697 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 741091014698 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 741091014699 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 741091014700 ImpA domain protein; Region: DUF3702; pfam12486 741091014701 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 741091014702 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 741091014703 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 741091014704 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 741091014705 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 741091014706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091014707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091014708 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 741091014709 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 741091014710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091014711 putative substrate translocation pore; other site 741091014712 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091014713 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 741091014714 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 741091014715 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091014716 Walker A/P-loop; other site 741091014717 ATP binding site [chemical binding]; other site 741091014718 Q-loop/lid; other site 741091014719 ABC transporter signature motif; other site 741091014720 Walker B; other site 741091014721 D-loop; other site 741091014722 H-loop/switch region; other site 741091014723 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 741091014724 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 741091014725 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091014726 Walker A/P-loop; other site 741091014727 ATP binding site [chemical binding]; other site 741091014728 Q-loop/lid; other site 741091014729 ABC transporter signature motif; other site 741091014730 Walker B; other site 741091014731 D-loop; other site 741091014732 H-loop/switch region; other site 741091014733 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091014734 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091014735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091014736 dimer interface [polypeptide binding]; other site 741091014737 conserved gate region; other site 741091014738 putative PBP binding loops; other site 741091014739 ABC-ATPase subunit interface; other site 741091014740 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091014741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091014742 dimer interface [polypeptide binding]; other site 741091014743 conserved gate region; other site 741091014744 putative PBP binding loops; other site 741091014745 ABC-ATPase subunit interface; other site 741091014746 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 741091014747 Autoinducer binding domain; Region: Autoind_bind; pfam03472 741091014748 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 741091014749 DNA binding residues [nucleotide binding] 741091014750 dimerization interface [polypeptide binding]; other site 741091014751 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 741091014752 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 741091014753 Cupin; Region: Cupin_6; pfam12852 741091014754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091014755 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091014756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091014757 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 741091014758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091014759 putative substrate translocation pore; other site 741091014760 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 741091014761 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 741091014762 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 741091014763 Transcriptional regulators [Transcription]; Region: FadR; COG2186 741091014764 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091014765 DNA-binding site [nucleotide binding]; DNA binding site 741091014766 FCD domain; Region: FCD; pfam07729 741091014767 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 741091014768 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 741091014769 NAD binding site [chemical binding]; other site 741091014770 homotetramer interface [polypeptide binding]; other site 741091014771 homodimer interface [polypeptide binding]; other site 741091014772 active site 741091014773 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 741091014774 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 741091014775 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 741091014776 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 741091014777 putative active site pocket [active] 741091014778 metal binding site [ion binding]; metal-binding site 741091014779 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 741091014780 Amidohydrolase; Region: Amidohydro_2; pfam04909 741091014781 short chain dehydrogenase; Provisional; Region: PRK08628 741091014782 classical (c) SDRs; Region: SDR_c; cd05233 741091014783 NAD(P) binding site [chemical binding]; other site 741091014784 active site 741091014785 Domain of unknown function (DUF718); Region: DUF718; pfam05336 741091014786 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 741091014787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091014788 putative substrate translocation pore; other site 741091014789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091014790 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 741091014791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091014792 dimerization interface [polypeptide binding]; other site 741091014793 putative DNA binding site [nucleotide binding]; other site 741091014794 putative Zn2+ binding site [ion binding]; other site 741091014795 ACT domain-containing protein [General function prediction only]; Region: COG4747 741091014796 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 741091014797 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 741091014798 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 741091014799 methionine synthase; Provisional; Region: PRK01207 741091014800 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 741091014801 substrate binding site [chemical binding]; other site 741091014802 THF binding site; other site 741091014803 zinc-binding site [ion binding]; other site 741091014804 YceI-like domain; Region: YceI; pfam04264 741091014805 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 741091014806 Zn2+ binding site [ion binding]; other site 741091014807 Mg2+ binding site [ion binding]; other site 741091014808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 741091014809 DNA binding site [nucleotide binding] 741091014810 YfaZ precursor; Region: YfaZ; pfam07437 741091014811 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 741091014812 methionine sulfoxide reductase A; Provisional; Region: PRK13014 741091014813 methionine sulfoxide reductase B; Provisional; Region: PRK00222 741091014814 SelR domain; Region: SelR; pfam01641 741091014815 alpha-glucosidase; Provisional; Region: PRK10426 741091014816 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 741091014817 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 741091014818 putative active site [active] 741091014819 putative catalytic site [active] 741091014820 putative symporter YagG; Provisional; Region: PRK09669 741091014821 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 741091014822 MarR family; Region: MarR_2; cl17246 741091014823 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 741091014824 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 741091014825 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 741091014826 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 741091014827 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 741091014828 active site 741091014829 metal binding site [ion binding]; metal-binding site 741091014830 nudix motif; other site 741091014831 AAA domain; Region: AAA_17; pfam13207 741091014832 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 741091014833 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 741091014834 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 741091014835 NADP binding site [chemical binding]; other site 741091014836 Predicted transcriptional regulators [Transcription]; Region: COG1733 741091014837 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 741091014838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 741091014839 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 741091014840 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 741091014841 active site 741091014842 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 741091014843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091014844 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 741091014845 dimerization interface [polypeptide binding]; other site 741091014846 substrate binding pocket [chemical binding]; other site 741091014847 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 741091014848 EamA-like transporter family; Region: EamA; cl17759 741091014849 EamA-like transporter family; Region: EamA; pfam00892 741091014850 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 741091014851 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 741091014852 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 741091014853 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 741091014854 putative active site [active] 741091014855 YdjC motif; other site 741091014856 Mg binding site [ion binding]; other site 741091014857 putative homodimer interface [polypeptide binding]; other site 741091014858 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 741091014859 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 741091014860 NAD binding site [chemical binding]; other site 741091014861 sugar binding site [chemical binding]; other site 741091014862 divalent metal binding site [ion binding]; other site 741091014863 tetramer (dimer of dimers) interface [polypeptide binding]; other site 741091014864 dimer interface [polypeptide binding]; other site 741091014865 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 741091014866 Cupin domain; Region: Cupin_2; pfam07883 741091014867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091014868 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 741091014869 methionine cluster; other site 741091014870 active site 741091014871 phosphorylation site [posttranslational modification] 741091014872 metal binding site [ion binding]; metal-binding site 741091014873 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 741091014874 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 741091014875 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 741091014876 active site 741091014877 P-loop; other site 741091014878 phosphorylation site [posttranslational modification] 741091014879 Transcriptional regulators [Transcription]; Region: PurR; COG1609 741091014880 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091014881 DNA binding site [nucleotide binding] 741091014882 domain linker motif; other site 741091014883 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 741091014884 putative dimerization interface [polypeptide binding]; other site 741091014885 putative ligand binding site [chemical binding]; other site 741091014886 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 741091014887 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 741091014888 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 741091014889 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 741091014890 Cytochrome c; Region: Cytochrom_C; cl11414 741091014891 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 741091014892 Cytochrome c; Region: Cytochrom_C; pfam00034 741091014893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 741091014894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091014895 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741091014896 putative substrate translocation pore; other site 741091014897 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091014898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091014899 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 741091014900 putative effector binding pocket; other site 741091014901 dimerization interface [polypeptide binding]; other site 741091014902 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 741091014903 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 741091014904 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 741091014905 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 741091014906 Sensors of blue-light using FAD; Region: BLUF; smart01034 741091014907 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091014908 tellurite resistance protein TehB; Provisional; Region: PRK11207 741091014909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 741091014910 S-adenosylmethionine binding site [chemical binding]; other site 741091014911 CsbD-like; Region: CsbD; pfam05532 741091014912 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 741091014913 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 741091014914 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 741091014915 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 741091014916 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 741091014917 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 741091014918 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 741091014919 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 741091014920 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 741091014921 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 741091014922 dimer interface [polypeptide binding]; other site 741091014923 active site 741091014924 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 741091014925 catalytic residues [active] 741091014926 substrate binding site [chemical binding]; other site 741091014927 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 741091014928 active site 741091014929 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 741091014930 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 741091014931 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 741091014932 acyl-activating enzyme (AAE) consensus motif; other site 741091014933 AMP binding site [chemical binding]; other site 741091014934 active site 741091014935 CoA binding site [chemical binding]; other site 741091014936 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 741091014937 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 741091014938 acyl-activating enzyme (AAE) consensus motif; other site 741091014939 AMP binding site [chemical binding]; other site 741091014940 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 741091014941 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 741091014942 acyl-activating enzyme (AAE) consensus motif; other site 741091014943 AMP binding site [chemical binding]; other site 741091014944 active site 741091014945 CoA binding site [chemical binding]; other site 741091014946 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 741091014947 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 741091014948 active site 741091014949 metal binding site [ion binding]; metal-binding site 741091014950 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 741091014951 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 741091014952 active site 741091014953 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 741091014954 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 741091014955 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 741091014956 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 741091014957 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 741091014958 active site 741091014959 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 741091014960 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; Region: ACP_syn_III; pfam08545 741091014961 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 741091014962 Cytochrome P450; Region: p450; cl12078 741091014963 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 741091014964 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 741091014965 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 741091014966 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 741091014967 PAS domain; Region: PAS; smart00091 741091014968 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 741091014969 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 741091014970 dimer interface [polypeptide binding]; other site 741091014971 phosphorylation site [posttranslational modification] 741091014972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091014973 ATP binding site [chemical binding]; other site 741091014974 Mg2+ binding site [ion binding]; other site 741091014975 G-X-G motif; other site 741091014976 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 741091014977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091014978 active site 741091014979 phosphorylation site [posttranslational modification] 741091014980 intermolecular recognition site; other site 741091014981 dimerization interface [polypeptide binding]; other site 741091014982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091014983 Walker A motif; other site 741091014984 ATP binding site [chemical binding]; other site 741091014985 Walker B motif; other site 741091014986 arginine finger; other site 741091014987 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 741091014988 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 741091014989 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 741091014990 FtsX-like permease family; Region: FtsX; pfam02687 741091014991 FtsX-like permease family; Region: FtsX; pfam02687 741091014992 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 741091014993 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 741091014994 Walker A/P-loop; other site 741091014995 ATP binding site [chemical binding]; other site 741091014996 Q-loop/lid; other site 741091014997 ABC transporter signature motif; other site 741091014998 Walker B; other site 741091014999 D-loop; other site 741091015000 H-loop/switch region; other site 741091015001 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 741091015002 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091015003 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091015004 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091015005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091015006 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741091015007 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 741091015008 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 741091015009 putative efflux protein, MATE family; Region: matE; TIGR00797 741091015010 acyl carrier protein; Provisional; Region: PRK07639 741091015011 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 741091015012 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 741091015013 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091015014 Walker A/P-loop; other site 741091015015 ATP binding site [chemical binding]; other site 741091015016 Q-loop/lid; other site 741091015017 ABC transporter signature motif; other site 741091015018 Walker B; other site 741091015019 D-loop; other site 741091015020 H-loop/switch region; other site 741091015021 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 741091015022 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091015023 Walker A/P-loop; other site 741091015024 ATP binding site [chemical binding]; other site 741091015025 Q-loop/lid; other site 741091015026 ABC transporter signature motif; other site 741091015027 Walker B; other site 741091015028 D-loop; other site 741091015029 H-loop/switch region; other site 741091015030 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 741091015031 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 741091015032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091015033 dimer interface [polypeptide binding]; other site 741091015034 conserved gate region; other site 741091015035 putative PBP binding loops; other site 741091015036 ABC-ATPase subunit interface; other site 741091015037 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091015038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091015039 dimer interface [polypeptide binding]; other site 741091015040 conserved gate region; other site 741091015041 putative PBP binding loops; other site 741091015042 ABC-ATPase subunit interface; other site 741091015043 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 741091015044 active site 741091015045 tetramer interface [polypeptide binding]; other site 741091015046 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 741091015047 active site 741091015048 tetramer interface [polypeptide binding]; other site 741091015049 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 741091015050 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 741091015051 inhibitor site; inhibition site 741091015052 active site 741091015053 dimer interface [polypeptide binding]; other site 741091015054 catalytic residue [active] 741091015055 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091015056 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 741091015057 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 741091015058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091015059 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091015060 dimerization interface [polypeptide binding]; other site 741091015061 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 741091015062 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 741091015063 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 741091015064 Trp docking motif [polypeptide binding]; other site 741091015065 putative active site [active] 741091015066 HipA N-terminal domain; Region: couple_hipA; TIGR03071 741091015067 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 741091015068 HipA-like N-terminal domain; Region: HipA_N; pfam07805 741091015069 HipA-like C-terminal domain; Region: HipA_C; pfam07804 741091015070 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 741091015071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091015072 non-specific DNA binding site [nucleotide binding]; other site 741091015073 salt bridge; other site 741091015074 sequence-specific DNA binding site [nucleotide binding]; other site 741091015075 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 741091015076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091015077 DNA-binding site [nucleotide binding]; DNA binding site 741091015078 UTRA domain; Region: UTRA; pfam07702 741091015079 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 741091015080 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 741091015081 metal binding site [ion binding]; metal-binding site 741091015082 substrate binding pocket [chemical binding]; other site 741091015083 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 741091015084 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741091015085 active site turn [active] 741091015086 phosphorylation site [posttranslational modification] 741091015087 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741091015088 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 741091015089 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 741091015090 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091015091 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091015092 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 741091015093 dimerization interface [polypeptide binding]; other site 741091015094 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 741091015095 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091015096 Walker A/P-loop; other site 741091015097 ATP binding site [chemical binding]; other site 741091015098 Q-loop/lid; other site 741091015099 ABC transporter signature motif; other site 741091015100 Walker B; other site 741091015101 D-loop; other site 741091015102 H-loop/switch region; other site 741091015103 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 741091015104 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 741091015105 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091015106 Walker A/P-loop; other site 741091015107 ATP binding site [chemical binding]; other site 741091015108 Q-loop/lid; other site 741091015109 ABC transporter signature motif; other site 741091015110 Walker B; other site 741091015111 D-loop; other site 741091015112 H-loop/switch region; other site 741091015113 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 741091015114 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091015115 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741091015116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091015117 dimer interface [polypeptide binding]; other site 741091015118 conserved gate region; other site 741091015119 putative PBP binding loops; other site 741091015120 ABC-ATPase subunit interface; other site 741091015121 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091015122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091015123 dimer interface [polypeptide binding]; other site 741091015124 conserved gate region; other site 741091015125 putative PBP binding loops; other site 741091015126 ABC-ATPase subunit interface; other site 741091015127 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091015128 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 741091015129 Initiator Replication protein; Region: Rep_3; pfam01051 741091015130 ParG; Region: ParG; pfam09274 741091015131 ParA-like protein; Provisional; Region: PHA02518 741091015132 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 741091015133 P-loop; other site 741091015134 Magnesium ion binding site [ion binding]; other site 741091015135 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 741091015136 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 741091015137 Walker A/P-loop; other site 741091015138 ATP binding site [chemical binding]; other site 741091015139 Q-loop/lid; other site 741091015140 ABC transporter signature motif; other site 741091015141 Walker B; other site 741091015142 D-loop; other site 741091015143 H-loop/switch region; other site 741091015144 TOBE domain; Region: TOBE_2; pfam08402 741091015145 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 741091015146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091015147 DNA-binding site [nucleotide binding]; DNA binding site 741091015148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 741091015149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091015150 homodimer interface [polypeptide binding]; other site 741091015151 catalytic residue [active] 741091015152 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 741091015153 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741091015154 inhibitor-cofactor binding pocket; inhibition site 741091015155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091015156 catalytic residue [active] 741091015157 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 741091015158 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 741091015159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091015160 dimer interface [polypeptide binding]; other site 741091015161 conserved gate region; other site 741091015162 putative PBP binding loops; other site 741091015163 ABC-ATPase subunit interface; other site 741091015164 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 741091015165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091015166 dimer interface [polypeptide binding]; other site 741091015167 conserved gate region; other site 741091015168 putative PBP binding loops; other site 741091015169 ABC-ATPase subunit interface; other site 741091015170 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 741091015171 classical (c) SDRs; Region: SDR_c; cd05233 741091015172 NAD(P) binding site [chemical binding]; other site 741091015173 active site 741091015174 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 741091015175 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 741091015176 active site 741091015177 ATP binding site [chemical binding]; other site 741091015178 substrate binding site [chemical binding]; other site 741091015179 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 741091015180 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741091015181 inhibitor-cofactor binding pocket; inhibition site 741091015182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091015183 catalytic residue [active] 741091015184 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091015185 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091015186 metal binding site [ion binding]; metal-binding site 741091015187 active site 741091015188 I-site; other site 741091015189 Transcriptional regulators [Transcription]; Region: GntR; COG1802 741091015190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091015191 DNA-binding site [nucleotide binding]; DNA binding site 741091015192 FCD domain; Region: FCD; pfam07729 741091015193 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 741091015194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091015195 putative substrate translocation pore; other site 741091015196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091015197 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 741091015198 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 741091015199 putative [Fe4-S4] binding site [ion binding]; other site 741091015200 putative molybdopterin cofactor binding site [chemical binding]; other site 741091015201 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 741091015202 putative molybdopterin cofactor binding site; other site 741091015203 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 741091015204 4Fe-4S binding domain; Region: Fer4; pfam00037 741091015205 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 741091015206 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 741091015207 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 741091015208 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 741091015209 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 741091015210 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 741091015211 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 741091015212 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 741091015213 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 741091015214 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 741091015215 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 741091015216 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 741091015217 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 741091015218 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 741091015219 NAD(P) binding site [chemical binding]; other site 741091015220 catalytic residues [active] 741091015221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091015222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091015223 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 741091015224 putative dimerization interface [polypeptide binding]; other site 741091015225 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 741091015226 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 741091015227 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 741091015228 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 741091015229 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 741091015230 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 741091015231 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 741091015232 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 741091015233 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 741091015234 Fic/DOC family; Region: Fic; pfam02661 741091015235 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091015236 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091015237 TM-ABC transporter signature motif; other site 741091015238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091015239 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 741091015240 TM-ABC transporter signature motif; other site 741091015241 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 741091015242 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 741091015243 Walker A/P-loop; other site 741091015244 ATP binding site [chemical binding]; other site 741091015245 Q-loop/lid; other site 741091015246 ABC transporter signature motif; other site 741091015247 Walker B; other site 741091015248 D-loop; other site 741091015249 H-loop/switch region; other site 741091015250 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 741091015251 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 741091015252 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 741091015253 ligand binding site [chemical binding]; other site 741091015254 transcriptional activator RhaS; Provisional; Region: PRK13503 741091015255 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 741091015256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091015257 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 741091015258 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 741091015259 NAD binding site [chemical binding]; other site 741091015260 catalytic residues [active] 741091015261 substrate binding site [chemical binding]; other site 741091015262 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 741091015263 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 741091015264 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 741091015265 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 741091015266 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 741091015267 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741091015268 N-terminal plug; other site 741091015269 ligand-binding site [chemical binding]; other site 741091015270 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 741091015271 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 741091015272 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 741091015273 Trp docking motif [polypeptide binding]; other site 741091015274 putative active site [active] 741091015275 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 741091015276 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 741091015277 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091015278 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091015279 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 741091015280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091015281 NAD(P) binding site [chemical binding]; other site 741091015282 active site 741091015283 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 741091015284 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 741091015285 Uncharacterized conserved protein [Function unknown]; Region: COG3268 741091015286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091015287 NAD(P) binding site [chemical binding]; other site 741091015288 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 741091015289 dimerization interface [polypeptide binding]; other site 741091015290 substrate binding pocket [chemical binding]; other site 741091015291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 741091015292 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 741091015293 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 741091015294 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 741091015295 putative dimer interface [polypeptide binding]; other site 741091015296 HTH domain; Region: HTH_11; pfam08279 741091015297 Predicted transcriptional regulator [Transcription]; Region: COG2378 741091015298 WYL domain; Region: WYL; pfam13280 741091015299 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741091015300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091015301 putative substrate translocation pore; other site 741091015302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091015303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091015304 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 741091015305 putative substrate binding pocket [chemical binding]; other site 741091015306 putative dimerization interface [polypeptide binding]; other site 741091015307 exodeoxyribonuclease X; Provisional; Region: PRK07983 741091015308 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 741091015309 active site 741091015310 catalytic site [active] 741091015311 substrate binding site [chemical binding]; other site 741091015312 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 741091015313 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 741091015314 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 741091015315 putative active site pocket [active] 741091015316 metal binding site [ion binding]; metal-binding site 741091015317 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091015318 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 741091015319 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091015320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091015321 dimer interface [polypeptide binding]; other site 741091015322 conserved gate region; other site 741091015323 putative PBP binding loops; other site 741091015324 ABC-ATPase subunit interface; other site 741091015325 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091015326 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 741091015327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091015328 dimer interface [polypeptide binding]; other site 741091015329 conserved gate region; other site 741091015330 ABC-ATPase subunit interface; other site 741091015331 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 741091015332 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091015333 Walker A/P-loop; other site 741091015334 ATP binding site [chemical binding]; other site 741091015335 Q-loop/lid; other site 741091015336 ABC transporter signature motif; other site 741091015337 Walker B; other site 741091015338 D-loop; other site 741091015339 H-loop/switch region; other site 741091015340 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091015341 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 741091015342 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091015343 Walker A/P-loop; other site 741091015344 ATP binding site [chemical binding]; other site 741091015345 Q-loop/lid; other site 741091015346 ABC transporter signature motif; other site 741091015347 Walker B; other site 741091015348 D-loop; other site 741091015349 H-loop/switch region; other site 741091015350 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 741091015351 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 741091015352 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 741091015353 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 741091015354 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 741091015355 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 741091015356 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 741091015357 PAAR motif; Region: PAAR_motif; pfam05488 741091015358 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 741091015359 Sel1-like repeats; Region: SEL1; smart00671 741091015360 Sel1-like repeats; Region: SEL1; smart00671 741091015361 Sel1-like repeats; Region: SEL1; smart00671 741091015362 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 741091015363 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 741091015364 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 741091015365 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 741091015366 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 741091015367 MarR family; Region: MarR_2; pfam12802 741091015368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091015369 Coenzyme A binding pocket [chemical binding]; other site 741091015370 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091015371 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 741091015372 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 741091015373 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 741091015374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091015375 Major Facilitator Superfamily; Region: MFS_1; pfam07690 741091015376 putative substrate translocation pore; other site 741091015377 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 741091015378 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091015379 Walker A/P-loop; other site 741091015380 ATP binding site [chemical binding]; other site 741091015381 Q-loop/lid; other site 741091015382 ABC transporter signature motif; other site 741091015383 Walker B; other site 741091015384 D-loop; other site 741091015385 H-loop/switch region; other site 741091015386 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 741091015387 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091015388 Walker A/P-loop; other site 741091015389 ATP binding site [chemical binding]; other site 741091015390 Q-loop/lid; other site 741091015391 ABC transporter signature motif; other site 741091015392 Walker B; other site 741091015393 D-loop; other site 741091015394 H-loop/switch region; other site 741091015395 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091015396 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 741091015397 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 741091015398 DNA binding site [nucleotide binding] 741091015399 domain linker motif; other site 741091015400 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 741091015401 dimerization interface [polypeptide binding]; other site 741091015402 ligand binding site [chemical binding]; other site 741091015403 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 741091015404 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 741091015405 substrate binding [chemical binding]; other site 741091015406 active site 741091015407 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 741091015408 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 741091015409 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 741091015410 active site turn [active] 741091015411 phosphorylation site [posttranslational modification] 741091015412 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 741091015413 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 741091015414 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 741091015415 trimer interface; other site 741091015416 sugar binding site [chemical binding]; other site 741091015417 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 741091015418 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 741091015419 putative substrate binding site [chemical binding]; other site 741091015420 putative ATP binding site [chemical binding]; other site 741091015421 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 741091015422 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741091015423 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741091015424 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741091015425 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741091015426 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 741091015427 Surface antigen; Region: Bac_surface_Ag; pfam01103 741091015428 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 741091015429 methionine sulfoxide reductase B; Provisional; Region: PRK05508 741091015430 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 741091015431 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 741091015432 Protein export membrane protein; Region: SecD_SecF; cl14618 741091015433 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 741091015434 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091015435 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091015436 Predicted transcriptional regulators [Transcription]; Region: COG1695 741091015437 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 741091015438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 741091015439 Protein of unknown function (DUF330); Region: DUF330; pfam03886 741091015440 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 741091015441 mce related protein; Region: MCE; pfam02470 741091015442 mce related protein; Region: MCE; pfam02470 741091015443 mce related protein; Region: MCE; pfam02470 741091015444 Paraquat-inducible protein A; Region: PqiA; pfam04403 741091015445 Paraquat-inducible protein A; Region: PqiA; pfam04403 741091015446 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 741091015447 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 741091015448 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741091015449 N-terminal plug; other site 741091015450 ligand-binding site [chemical binding]; other site 741091015451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091015452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091015453 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 741091015454 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 741091015455 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 741091015456 FAD binding pocket [chemical binding]; other site 741091015457 FAD binding motif [chemical binding]; other site 741091015458 phosphate binding motif [ion binding]; other site 741091015459 NAD binding pocket [chemical binding]; other site 741091015460 Predicted transcriptional regulators [Transcription]; Region: COG1695 741091015461 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 741091015462 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 741091015463 active site 741091015464 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 741091015465 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 741091015466 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 741091015467 Moco binding site; other site 741091015468 metal coordination site [ion binding]; other site 741091015469 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 741091015470 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 741091015471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 741091015472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091015473 active site 741091015474 phosphorylation site [posttranslational modification] 741091015475 intermolecular recognition site; other site 741091015476 dimerization interface [polypeptide binding]; other site 741091015477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 741091015478 DNA binding site [nucleotide binding] 741091015479 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 741091015480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 741091015481 dimer interface [polypeptide binding]; other site 741091015482 phosphorylation site [posttranslational modification] 741091015483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091015484 ATP binding site [chemical binding]; other site 741091015485 Mg2+ binding site [ion binding]; other site 741091015486 G-X-G motif; other site 741091015487 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 741091015488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091015489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091015490 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 741091015491 dimerization interface [polypeptide binding]; other site 741091015492 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 741091015493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091015494 non-specific DNA binding site [nucleotide binding]; other site 741091015495 salt bridge; other site 741091015496 sequence-specific DNA binding site [nucleotide binding]; other site 741091015497 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 741091015498 HipA-like N-terminal domain; Region: HipA_N; pfam07805 741091015499 HipA-like C-terminal domain; Region: HipA_C; pfam07804 741091015500 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 741091015501 putative heme utilization carrier protein HutX; Region: HutX; TIGR04108 741091015502 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 741091015503 NADH(P)-binding; Region: NAD_binding_10; pfam13460 741091015504 NAD(P) binding site [chemical binding]; other site 741091015505 putative active site [active] 741091015506 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 741091015507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091015508 FeS/SAM binding site; other site 741091015509 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 741091015510 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 741091015511 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 741091015512 phosphate binding site [ion binding]; other site 741091015513 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091015514 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091015515 metal binding site [ion binding]; metal-binding site 741091015516 active site 741091015517 I-site; other site 741091015518 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 741091015519 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 741091015520 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 741091015521 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 741091015522 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 741091015523 FeS/SAM binding site; other site 741091015524 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 741091015525 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 741091015526 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 741091015527 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 741091015528 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 741091015529 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 741091015530 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 741091015531 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 741091015532 active site 741091015533 dimer interface [polypeptide binding]; other site 741091015534 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 741091015535 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741091015536 N-terminal plug; other site 741091015537 ligand-binding site [chemical binding]; other site 741091015538 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 741091015539 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 741091015540 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 741091015541 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 741091015542 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 741091015543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091015544 dimer interface [polypeptide binding]; other site 741091015545 conserved gate region; other site 741091015546 putative PBP binding loops; other site 741091015547 ABC-ATPase subunit interface; other site 741091015548 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 741091015549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091015550 dimer interface [polypeptide binding]; other site 741091015551 conserved gate region; other site 741091015552 ABC-ATPase subunit interface; other site 741091015553 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 741091015554 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091015555 Walker A/P-loop; other site 741091015556 ATP binding site [chemical binding]; other site 741091015557 Q-loop/lid; other site 741091015558 ABC transporter signature motif; other site 741091015559 Walker B; other site 741091015560 D-loop; other site 741091015561 H-loop/switch region; other site 741091015562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 741091015563 Walker A/P-loop; other site 741091015564 ATP binding site [chemical binding]; other site 741091015565 Q-loop/lid; other site 741091015566 ABC transporter signature motif; other site 741091015567 Walker B; other site 741091015568 D-loop; other site 741091015569 H-loop/switch region; other site 741091015570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 741091015571 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 741091015572 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 741091015573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 741091015574 dimerization interface [polypeptide binding]; other site 741091015575 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 741091015576 dimer interface [polypeptide binding]; other site 741091015577 putative CheW interface [polypeptide binding]; other site 741091015578 beta-lactamase TEM; Provisional; Region: PRK15442 741091015579 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 741091015580 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 741091015581 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 741091015582 inhibitor-cofactor binding pocket; inhibition site 741091015583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091015584 catalytic residue [active] 741091015585 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 741091015586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 741091015587 catalytic residue [active] 741091015588 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 741091015589 Mechanosensitive ion channel; Region: MS_channel; pfam00924 741091015590 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 741091015591 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 741091015592 active site 741091015593 catalytic site [active] 741091015594 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 741091015595 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 741091015596 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 741091015597 catalytic site [active] 741091015598 active site 741091015599 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 741091015600 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 741091015601 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 741091015602 intersubunit interface [polypeptide binding]; other site 741091015603 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 741091015604 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 741091015605 C-terminal domain interface [polypeptide binding]; other site 741091015606 GSH binding site (G-site) [chemical binding]; other site 741091015607 dimer interface [polypeptide binding]; other site 741091015608 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 741091015609 dimer interface [polypeptide binding]; other site 741091015610 N-terminal domain interface [polypeptide binding]; other site 741091015611 putative substrate binding pocket (H-site) [chemical binding]; other site 741091015612 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 741091015613 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 741091015614 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091015615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091015616 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 741091015617 dimerization interface [polypeptide binding]; other site 741091015618 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 741091015619 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 741091015620 GAF domain; Region: GAF; cl17456 741091015621 Histidine kinase; Region: His_kinase; pfam06580 741091015622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091015623 ATP binding site [chemical binding]; other site 741091015624 Mg2+ binding site [ion binding]; other site 741091015625 G-X-G motif; other site 741091015626 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 741091015627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091015628 active site 741091015629 phosphorylation site [posttranslational modification] 741091015630 intermolecular recognition site; other site 741091015631 dimerization interface [polypeptide binding]; other site 741091015632 LytTr DNA-binding domain; Region: LytTR; smart00850 741091015633 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 741091015634 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 741091015635 P-loop, Walker A motif; other site 741091015636 Base recognition motif; other site 741091015637 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 741091015638 Uncharacterized small protein [Function unknown]; Region: COG2879 741091015639 carbon starvation protein A; Provisional; Region: PRK15015 741091015640 Carbon starvation protein CstA; Region: CstA; pfam02554 741091015641 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 741091015642 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 741091015643 beta-galactosidase; Region: BGL; TIGR03356 741091015644 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 741091015645 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 741091015646 active site 741091015647 DNA binding site [nucleotide binding] 741091015648 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 741091015649 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 741091015650 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 741091015651 Catalytic site [active] 741091015652 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 741091015653 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 741091015654 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 741091015655 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 741091015656 Walker A/P-loop; other site 741091015657 ATP binding site [chemical binding]; other site 741091015658 Q-loop/lid; other site 741091015659 ABC transporter signature motif; other site 741091015660 Walker B; other site 741091015661 D-loop; other site 741091015662 H-loop/switch region; other site 741091015663 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 741091015664 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 741091015665 Walker A/P-loop; other site 741091015666 ATP binding site [chemical binding]; other site 741091015667 Q-loop/lid; other site 741091015668 ABC transporter signature motif; other site 741091015669 Walker B; other site 741091015670 D-loop; other site 741091015671 H-loop/switch region; other site 741091015672 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 741091015673 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 741091015674 TM-ABC transporter signature motif; other site 741091015675 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 741091015676 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 741091015677 TM-ABC transporter signature motif; other site 741091015678 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 741091015679 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 741091015680 ligand binding site [chemical binding]; other site 741091015681 Transcriptional regulators [Transcription]; Region: GntR; COG1802 741091015682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091015683 DNA-binding site [nucleotide binding]; DNA binding site 741091015684 FCD domain; Region: FCD; pfam07729 741091015685 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 741091015686 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 741091015687 metal binding site [ion binding]; metal-binding site 741091015688 putative dimer interface [polypeptide binding]; other site 741091015689 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 741091015690 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 741091015691 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 741091015692 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 741091015693 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 741091015694 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 741091015695 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 741091015696 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 741091015697 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 741091015698 Walker A/P-loop; other site 741091015699 ATP binding site [chemical binding]; other site 741091015700 Q-loop/lid; other site 741091015701 ABC transporter signature motif; other site 741091015702 Walker B; other site 741091015703 D-loop; other site 741091015704 H-loop/switch region; other site 741091015705 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 741091015706 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 741091015707 Walker A/P-loop; other site 741091015708 ATP binding site [chemical binding]; other site 741091015709 Q-loop/lid; other site 741091015710 ABC transporter signature motif; other site 741091015711 Walker B; other site 741091015712 D-loop; other site 741091015713 H-loop/switch region; other site 741091015714 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 741091015715 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091015716 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091015717 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 741091015718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091015719 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 741091015720 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 741091015721 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 741091015722 dimer interface [polypeptide binding]; other site 741091015723 active site 741091015724 metal binding site [ion binding]; metal-binding site 741091015725 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 741091015726 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 741091015727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091015728 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 741091015729 substrate binding pocket [chemical binding]; other site 741091015730 dimerization interface [polypeptide binding]; other site 741091015731 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091015732 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091015733 active site 741091015734 catalytic tetrad [active] 741091015735 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 741091015736 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 741091015737 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 741091015738 putative active site [active] 741091015739 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 741091015740 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 741091015741 putative active site [active] 741091015742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091015743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091015744 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 741091015745 putative effector binding pocket; other site 741091015746 putative dimerization interface [polypeptide binding]; other site 741091015747 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 741091015748 Domain of unknown function DUF; Region: DUF204; pfam02659 741091015749 Domain of unknown function DUF; Region: DUF204; pfam02659 741091015750 Protein of unknown function (DUF770); Region: DUF770; pfam05591 741091015751 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 741091015752 Protein of unknown function (DUF877); Region: DUF877; pfam05943 741091015753 Protein of unknown function (DUF796); Region: DUF796; pfam05638 741091015754 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 741091015755 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 741091015756 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 741091015757 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 741091015758 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 741091015759 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 741091015760 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 741091015761 PAAR motif; Region: PAAR_motif; pfam05488 741091015762 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 741091015763 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 741091015764 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 741091015765 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 741091015766 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 741091015767 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 741091015768 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 741091015769 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 741091015770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091015771 Walker A motif; other site 741091015772 ATP binding site [chemical binding]; other site 741091015773 Walker B motif; other site 741091015774 arginine finger; other site 741091015775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 741091015776 Walker A motif; other site 741091015777 ATP binding site [chemical binding]; other site 741091015778 Walker B motif; other site 741091015779 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 741091015780 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 741091015781 ImpA domain protein; Region: DUF3702; pfam12486 741091015782 K+ potassium transporter; Region: K_trans; cl15781 741091015783 potassium uptake protein; Region: kup; TIGR00794 741091015784 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 741091015785 Beta-lactamase; Region: Beta-lactamase; pfam00144 741091015786 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 741091015787 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 741091015788 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 741091015789 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 741091015790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091015791 active site 741091015792 motif I; other site 741091015793 motif II; other site 741091015794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 741091015795 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 741091015796 manganese transport regulator MntR; Provisional; Region: PRK11050 741091015797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091015798 DNA-binding site [nucleotide binding]; DNA binding site 741091015799 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 741091015800 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 741091015801 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 741091015802 metal binding site [ion binding]; metal-binding site 741091015803 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 741091015804 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 741091015805 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 741091015806 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741091015807 ABC-ATPase subunit interface; other site 741091015808 dimer interface [polypeptide binding]; other site 741091015809 putative PBP binding regions; other site 741091015810 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 741091015811 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 741091015812 ABC-ATPase subunit interface; other site 741091015813 dimer interface [polypeptide binding]; other site 741091015814 putative PBP binding regions; other site 741091015815 tryptophan permease; Provisional; Region: PRK10483 741091015816 aromatic amino acid transport protein; Region: araaP; TIGR00837 741091015817 Pirin-related protein [General function prediction only]; Region: COG1741 741091015818 Pirin; Region: Pirin; pfam02678 741091015819 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091015820 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 741091015821 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 741091015822 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 741091015823 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 741091015824 dimer interface [polypeptide binding]; other site 741091015825 active site 741091015826 Int/Topo IB signature motif; other site 741091015827 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 741091015828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091015829 non-specific DNA binding site [nucleotide binding]; other site 741091015830 salt bridge; other site 741091015831 sequence-specific DNA binding site [nucleotide binding]; other site 741091015832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091015833 non-specific DNA binding site [nucleotide binding]; other site 741091015834 salt bridge; other site 741091015835 sequence-specific DNA binding site [nucleotide binding]; other site 741091015836 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 741091015837 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 741091015838 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 741091015839 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 741091015840 Flagellar protein (FlbD); Region: FlbD; cl00683 741091015841 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 741091015842 Protein of unknown function (DUF968); Region: DUF968; pfam06147 741091015843 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 741091015844 Lysis protein S; Region: Lysis_S; pfam04971 741091015845 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 741091015846 catalytic residues [active] 741091015847 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 741091015848 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 741091015849 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 741091015850 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 741091015851 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 741091015852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 741091015853 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 741091015854 Striatin family; Region: Striatin; pfam08232 741091015855 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 741091015856 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 741091015857 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 741091015858 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 741091015859 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 741091015860 N-acetyl-D-glucosamine binding site [chemical binding]; other site 741091015861 catalytic residue [active] 741091015862 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 741091015863 Baseplate J-like protein; Region: Baseplate_J; cl01294 741091015864 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 741091015865 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 741091015866 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 741091015867 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 741091015868 H+ Antiporter protein; Region: 2A0121; TIGR00900 741091015869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091015870 putative substrate translocation pore; other site 741091015871 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 741091015872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091015873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091015874 C factor cell-cell signaling protein; Provisional; Region: PRK09009 741091015875 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 741091015876 NADP binding site [chemical binding]; other site 741091015877 homodimer interface [polypeptide binding]; other site 741091015878 active site 741091015879 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 741091015880 malate dehydrogenase; Provisional; Region: PRK13529 741091015881 Malic enzyme, N-terminal domain; Region: malic; pfam00390 741091015882 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 741091015883 NAD(P) binding site [chemical binding]; other site 741091015884 Predicted permeases [General function prediction only]; Region: COG0679 741091015885 fumarate hydratase; Provisional; Region: PRK15389 741091015886 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 741091015887 Fumarase C-terminus; Region: Fumerase_C; pfam05683 741091015888 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 741091015889 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 741091015890 transmembrane helices; other site 741091015891 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 741091015892 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 741091015893 putative active site [active] 741091015894 putative FMN binding site [chemical binding]; other site 741091015895 putative substrate binding site [chemical binding]; other site 741091015896 putative catalytic residue [active] 741091015897 FMN-binding domain; Region: FMN_bind; cl01081 741091015898 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 741091015899 L-aspartate oxidase; Provisional; Region: PRK06175 741091015900 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 741091015901 ApbE family; Region: ApbE; pfam02424 741091015902 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 741091015903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 741091015904 active site 741091015905 phosphorylation site [posttranslational modification] 741091015906 intermolecular recognition site; other site 741091015907 dimerization interface [polypeptide binding]; other site 741091015908 sensory histidine kinase DcuS; Provisional; Region: PRK11086 741091015909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 741091015910 ATP binding site [chemical binding]; other site 741091015911 Mg2+ binding site [ion binding]; other site 741091015912 G-X-G motif; other site 741091015913 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 741091015914 oxidoreductase; Provisional; Region: PRK06128 741091015915 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 741091015916 NAD binding site [chemical binding]; other site 741091015917 metal binding site [ion binding]; metal-binding site 741091015918 active site 741091015919 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 741091015920 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 741091015921 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 741091015922 putative active site [active] 741091015923 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 741091015924 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 741091015925 N-terminal plug; other site 741091015926 ligand-binding site [chemical binding]; other site 741091015927 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 741091015928 intersubunit interface [polypeptide binding]; other site 741091015929 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 741091015930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091015931 putative substrate translocation pore; other site 741091015932 POT family; Region: PTR2; cl17359 741091015933 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 741091015934 ArsC family; Region: ArsC; pfam03960 741091015935 catalytic residues [active] 741091015936 arsenical pump membrane protein; Provisional; Region: PRK15445 741091015937 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 741091015938 transmembrane helices; other site 741091015939 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 741091015940 dimerization interface [polypeptide binding]; other site 741091015941 putative DNA binding site [nucleotide binding]; other site 741091015942 putative Zn2+ binding site [ion binding]; other site 741091015943 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 741091015944 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 741091015945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091015946 ABC-ATPase subunit interface; other site 741091015947 putative PBP binding loops; other site 741091015948 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 741091015949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 741091015950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 741091015951 dimer interface [polypeptide binding]; other site 741091015952 ABC-ATPase subunit interface; other site 741091015953 putative PBP binding loops; other site 741091015954 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 741091015955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 741091015956 Walker A/P-loop; other site 741091015957 ATP binding site [chemical binding]; other site 741091015958 Q-loop/lid; other site 741091015959 ABC transporter signature motif; other site 741091015960 Walker B; other site 741091015961 D-loop; other site 741091015962 H-loop/switch region; other site 741091015963 TOBE domain; Region: TOBE_2; pfam08402 741091015964 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 741091015965 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 741091015966 active site 741091015967 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091015968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091015969 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 741091015970 dimerization interface [polypeptide binding]; other site 741091015971 substrate binding pocket [chemical binding]; other site 741091015972 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 741091015973 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 741091015974 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 741091015975 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 741091015976 putative NAD(P) binding site [chemical binding]; other site 741091015977 active site 741091015978 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091015979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091015980 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 741091015981 toxin interface [polypeptide binding]; other site 741091015982 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 741091015983 Zn binding site [ion binding]; other site 741091015984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 741091015985 non-specific DNA binding site [nucleotide binding]; other site 741091015986 salt bridge; other site 741091015987 sequence-specific DNA binding site [nucleotide binding]; other site 741091015988 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 741091015989 peptide binding site [polypeptide binding]; other site 741091015990 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 741091015991 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 741091015992 Antirestriction protein (ArdA); Region: ArdA; pfam07275 741091015993 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 741091015994 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 741091015995 DNA methylase; Region: N6_N4_Mtase; cl17433 741091015996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 741091015997 Transposase; Region: DEDD_Tnp_IS110; pfam01548 741091015998 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 741091015999 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 741091016000 ParB-like nuclease domain; Region: ParB; smart00470 741091016001 ParB family; Region: ParB; pfam08775 741091016002 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 741091016003 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 741091016004 Magnesium ion binding site [ion binding]; other site 741091016005 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 741091016006 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 741091016007 Initiator Replication protein; Region: Rep_3; pfam01051 741091016008 ParA-like protein; Provisional; Region: PHA02518 741091016009 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 741091016010 P-loop; other site 741091016011 Magnesium ion binding site [ion binding]; other site 741091016012 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741091016013 active site 741091016014 DNA binding site [nucleotide binding] 741091016015 Int/Topo IB signature motif; other site 741091016016 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741091016017 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 741091016018 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 741091016019 outer membrane usher protein; Provisional; Region: PRK15193 741091016020 PapC N-terminal domain; Region: PapC_N; pfam13954 741091016021 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 741091016022 PapC C-terminal domain; Region: PapC_C; pfam13953 741091016023 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741091016024 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 741091016025 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 741091016026 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 741091016027 Autotransporter beta-domain; Region: Autotransporter; pfam03797 741091016028 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 741091016029 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 741091016030 DNA binding site [nucleotide binding] 741091016031 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 741091016032 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 741091016033 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 741091016034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 741091016035 Transposase; Region: HTH_Tnp_1; pfam01527 741091016036 putative transposase OrfB; Reviewed; Region: PHA02517 741091016037 HTH-like domain; Region: HTH_21; pfam13276 741091016038 Integrase core domain; Region: rve; pfam00665 741091016039 Integrase core domain; Region: rve_3; pfam13683 741091016040 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 741091016041 putative active site [active] 741091016042 putative metal-binding site [ion binding]; other site 741091016043 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 741091016044 Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443 741091016045 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 741091016046 active site 741091016047 catalytic residues [active] 741091016048 DNA binding site [nucleotide binding] 741091016049 Int/Topo IB signature motif; other site 741091016050 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 741091016051 Cache domain; Region: Cache_1; pfam02743 741091016052 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 741091016053 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 741091016054 metal binding site [ion binding]; metal-binding site 741091016055 active site 741091016056 I-site; other site 741091016057 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 741091016058 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 741091016059 putative active site [active] 741091016060 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 741091016061 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 741091016062 Walker A/P-loop; other site 741091016063 ATP binding site [chemical binding]; other site 741091016064 Q-loop/lid; other site 741091016065 ABC transporter signature motif; other site 741091016066 Walker B; other site 741091016067 D-loop; other site 741091016068 H-loop/switch region; other site 741091016069 HlyD family secretion protein; Region: HlyD; pfam00529 741091016070 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 741091016071 HlyD family secretion protein; Region: HlyD_3; pfam13437 741091016072 CAAX protease self-immunity; Region: Abi; pfam02517 741091016073 Phage integrase family; Region: Phage_integrase; pfam00589 741091016074 active site 741091016075 DNA binding site [nucleotide binding] 741091016076 Int/Topo IB signature motif; other site 741091016077 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 741091016078 active site 741091016079 NTP binding site [chemical binding]; other site 741091016080 metal binding triad [ion binding]; metal-binding site 741091016081 HTH-like domain; Region: HTH_21; pfam13276 741091016082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 741091016083 Integrase core domain; Region: rve; pfam00665 741091016084 Integrase core domain; Region: rve_3; pfam13683 741091016085 Transposase; Region: HTH_Tnp_1; pfam01527 741091016086 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 741091016087 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 741091016088 multiple promoter invertase; Provisional; Region: mpi; PRK13413 741091016089 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 741091016090 catalytic residues [active] 741091016091 catalytic nucleophile [active] 741091016092 Presynaptic Site I dimer interface [polypeptide binding]; other site 741091016093 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 741091016094 Synaptic Flat tetramer interface [polypeptide binding]; other site 741091016095 Synaptic Site I dimer interface [polypeptide binding]; other site 741091016096 DNA binding site [nucleotide binding] 741091016097 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 741091016098 DNA-binding interface [nucleotide binding]; DNA binding site 741091016099 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 741091016100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091016101 NAD(P) binding site [chemical binding]; other site 741091016102 active site 741091016103 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 741091016104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 741091016105 NAD(P) binding site [chemical binding]; other site 741091016106 active site 741091016107 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 741091016108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091016109 putative substrate translocation pore; other site 741091016110 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 741091016111 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 741091016112 conserved cys residue [active] 741091016113 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091016114 Cupin; Region: Cupin_6; pfam12852 741091016115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091016116 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091016117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091016118 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 741091016119 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 741091016120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 741091016121 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 741091016122 putative substrate translocation pore; other site 741091016123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091016124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091016125 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 741091016126 putative effector binding pocket; other site 741091016127 dimerization interface [polypeptide binding]; other site 741091016128 Cupin; Region: Cupin_6; pfam12852 741091016129 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 741091016130 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 741091016131 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 741091016132 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 741091016133 active site 741091016134 catalytic tetrad [active] 741091016135 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 741091016136 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 741091016137 active site 741091016138 DNA binding site [nucleotide binding] 741091016139 Int/Topo IB signature motif; other site 741091016140 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 741091016141 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 741091016142 putative trimer interface [polypeptide binding]; other site 741091016143 putative active site [active] 741091016144 putative substrate binding site [chemical binding]; other site 741091016145 putative CoA binding site [chemical binding]; other site 741091016146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 741091016147 Transcriptional regulator [Transcription]; Region: LysR; COG0583 741091016148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 741091016149 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 741091016150 putative effector binding pocket; other site 741091016151 dimerization interface [polypeptide binding]; other site 741091016152 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 741091016153 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 741091016154 putative NAD(P) binding site [chemical binding]; other site 741091016155 Uncharacterized conserved protein [Function unknown]; Region: COG1359 741091016156 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 741091016157 Coenzyme A binding pocket [chemical binding]; other site 741091016158 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 741091016159 nudix motif; other site 741091016160 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 741091016161 Abortive infection C-terminus; Region: Abi_C; pfam14355 741091016162 Paramyxovirus nucleocapsid protein; Region: Paramyxo_ncap; pfam00973 741091016163 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 741091016164 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 741091016165 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 741091016166 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 741091016167 DNA binding site [nucleotide binding] 741091016168 dimer interface [polypeptide binding]; other site 741091016169 active site 741091016170 Int/Topo IB signature motif; other site 741091016171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 741091016172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 741091016173 CAAX protease self-immunity; Region: Abi; pfam02517 741091016174 GAF domain; Region: GAF; pfam01590 741091016175 GAF domain; Region: GAF_2; pfam13185 741091016176 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 741091016177 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 741091016178 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 741091016179 active site 741091016180 metal binding site [ion binding]; metal-binding site 741091016181 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 741091016182 Domain of unknown function (DUF336); Region: DUF336; cl01249 741091016183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 741091016184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 741091016185 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 741091016186 Tautomerase enzyme; Region: Tautomerase; pfam01361 741091016187 Uncharacterized conserved protein [Function unknown]; Region: COG1359 741091016188 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 741091016189 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 741091016190 active site 741091016191 metal binding site [ion binding]; metal-binding site 741091016192 Uncharacterized conserved protein [Function unknown]; Region: COG3379 741091016193 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 741091016194 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 741091016195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 741091016196 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 741091016197 DNA-binding site [nucleotide binding]; DNA binding site 741091016198 DeoR C terminal sensor domain; Region: DeoRC; pfam00455