-- dump date   	20140620_023244
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
402626000001	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
402626000002	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
402626000003	G1 box; other site
402626000004	putative GEF interaction site [polypeptide binding]; other site
402626000005	GTP/Mg2+ binding site [chemical binding]; other site
402626000006	Switch I region; other site
402626000007	G2 box; other site
402626000008	G3 box; other site
402626000009	Switch II region; other site
402626000010	G4 box; other site
402626000011	G5 box; other site
402626000012	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
402626000013	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
402626000014	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
402626000015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626000016	active site
402626000017	phosphorylation site [posttranslational modification]
402626000018	intermolecular recognition site; other site
402626000019	dimerization interface [polypeptide binding]; other site
402626000020	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626000021	Walker A motif; other site
402626000022	ATP binding site [chemical binding]; other site
402626000023	Walker B motif; other site
402626000024	arginine finger; other site
402626000025	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626000026	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
402626000027	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626000028	Walker A motif; other site
402626000029	ATP binding site [chemical binding]; other site
402626000030	Walker B motif; other site
402626000031	arginine finger; other site
402626000032	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626000033	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
402626000034	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
402626000035	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
402626000036	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
402626000037	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
402626000038	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
402626000039	Predicted deacetylase [General function prediction only]; Region: COG3233
402626000040	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
402626000041	putative active site [active]
402626000042	putative Zn binding site [ion binding]; other site
402626000043	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
402626000044	active site
402626000045	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
402626000046	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
402626000047	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
402626000048	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626000049	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
402626000050	putative active site [active]
402626000051	heme pocket [chemical binding]; other site
402626000052	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626000053	putative active site [active]
402626000054	heme pocket [chemical binding]; other site
402626000055	PAS fold; Region: PAS_4; pfam08448
402626000056	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626000057	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626000058	dimer interface [polypeptide binding]; other site
402626000059	phosphorylation site [posttranslational modification]
402626000060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626000061	ATP binding site [chemical binding]; other site
402626000062	Mg2+ binding site [ion binding]; other site
402626000063	G-X-G motif; other site
402626000064	Response regulator receiver domain; Region: Response_reg; pfam00072
402626000065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626000066	active site
402626000067	phosphorylation site [posttranslational modification]
402626000068	intermolecular recognition site; other site
402626000069	dimerization interface [polypeptide binding]; other site
402626000070	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
402626000071	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
402626000072	DNA binding site [nucleotide binding]
402626000073	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
402626000074	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
402626000075	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
402626000076	DNA-binding site [nucleotide binding]; DNA binding site
402626000077	RNA-binding motif; other site
402626000078	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
402626000079	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
402626000080	P-loop; other site
402626000081	Magnesium ion binding site [ion binding]; other site
402626000082	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
402626000083	ParB-like nuclease domain; Region: ParBc; pfam02195
402626000084	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
402626000085	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
402626000086	active site
402626000087	tetramer interface; other site
402626000088	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
402626000089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626000090	putative substrate translocation pore; other site
402626000091	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
402626000092	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626000093	dimer interface [polypeptide binding]; other site
402626000094	phosphorylation site [posttranslational modification]
402626000095	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626000096	ATP binding site [chemical binding]; other site
402626000097	Mg2+ binding site [ion binding]; other site
402626000098	G-X-G motif; other site
402626000099	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
402626000100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626000101	active site
402626000102	phosphorylation site [posttranslational modification]
402626000103	intermolecular recognition site; other site
402626000104	dimerization interface [polypeptide binding]; other site
402626000105	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626000106	Walker A motif; other site
402626000107	ATP binding site [chemical binding]; other site
402626000108	Walker B motif; other site
402626000109	arginine finger; other site
402626000110	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626000111	Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810
402626000112	Cache domain; Region: Cache_1; pfam02743
402626000113	FOG: HAMP domain [Signal transduction mechanisms]; Region: ResE; COG2770
402626000114	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626000115	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
402626000116	putative active site [active]
402626000117	heme pocket [chemical binding]; other site
402626000118	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626000119	putative active site [active]
402626000120	heme pocket [chemical binding]; other site
402626000121	PAS domain; Region: PAS; smart00091
402626000122	PAS fold; Region: PAS_4; pfam08448
402626000123	putative active site [active]
402626000124	heme pocket [chemical binding]; other site
402626000125	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626000126	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626000127	metal binding site [ion binding]; metal-binding site
402626000128	active site
402626000129	I-site; other site
402626000130	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
402626000131	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
402626000132	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626000133	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
402626000134	TM-ABC transporter signature motif; other site
402626000135	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
402626000136	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
402626000137	TM-ABC transporter signature motif; other site
402626000138	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
402626000139	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
402626000140	Walker A/P-loop; other site
402626000141	ATP binding site [chemical binding]; other site
402626000142	Q-loop/lid; other site
402626000143	ABC transporter signature motif; other site
402626000144	Walker B; other site
402626000145	D-loop; other site
402626000146	H-loop/switch region; other site
402626000147	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
402626000148	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
402626000149	Walker A/P-loop; other site
402626000150	ATP binding site [chemical binding]; other site
402626000151	Q-loop/lid; other site
402626000152	ABC transporter signature motif; other site
402626000153	Walker B; other site
402626000154	D-loop; other site
402626000155	H-loop/switch region; other site
402626000156	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626000157	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626000158	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626000159	dimerization interface [polypeptide binding]; other site
402626000160	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
402626000161	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
402626000162	NADP binding site [chemical binding]; other site
402626000163	dimer interface [polypeptide binding]; other site
402626000164	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
402626000165	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
402626000166	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
402626000167	Cl- selectivity filter; other site
402626000168	Cl- binding residues [ion binding]; other site
402626000169	pore gating glutamate residue; other site
402626000170	dimer interface [polypeptide binding]; other site
402626000171	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
402626000172	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
402626000173	N-terminal plug; other site
402626000174	ligand-binding site [chemical binding]; other site
402626000175	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
402626000176	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
402626000177	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
402626000178	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626000179	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
402626000180	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
402626000181	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626000182	substrate binding pocket [chemical binding]; other site
402626000183	membrane-bound complex binding site; other site
402626000184	hinge residues; other site
402626000185	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626000186	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626000187	dimer interface [polypeptide binding]; other site
402626000188	phosphorylation site [posttranslational modification]
402626000189	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626000190	ATP binding site [chemical binding]; other site
402626000191	Mg2+ binding site [ion binding]; other site
402626000192	G-X-G motif; other site
402626000193	Response regulator receiver domain; Region: Response_reg; pfam00072
402626000194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626000195	active site
402626000196	phosphorylation site [posttranslational modification]
402626000197	intermolecular recognition site; other site
402626000198	dimerization interface [polypeptide binding]; other site
402626000199	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
402626000200	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
402626000201	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
402626000202	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
402626000203	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
402626000204	PapC N-terminal domain; Region: PapC_N; pfam13954
402626000205	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
402626000206	PapC C-terminal domain; Region: PapC_C; pfam13953
402626000207	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
402626000208	Transposase; Region: HTH_Tnp_1; cl17663
402626000209	putative transposase OrfB; Reviewed; Region: PHA02517
402626000210	HTH-like domain; Region: HTH_21; pfam13276
402626000211	Integrase core domain; Region: rve; pfam00665
402626000212	Integrase core domain; Region: rve_3; pfam13683
402626000213	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
402626000214	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
402626000215	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626000216	putative DNA binding site [nucleotide binding]; other site
402626000217	dimerization interface [polypeptide binding]; other site
402626000218	Transcriptional regulators [Transcription]; Region: MarR; COG1846
402626000219	putative Zn2+ binding site [ion binding]; other site
402626000220	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626000221	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
402626000222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626000223	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
402626000224	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
402626000225	Na binding site [ion binding]; other site
402626000226	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
402626000227	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
402626000228	Sodium Bile acid symporter family; Region: SBF; cl17470
402626000229	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
402626000230	Low molecular weight phosphatase family; Region: LMWPc; cd00115
402626000231	active site
402626000232	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
402626000233	putative metal binding site [ion binding]; other site
402626000234	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626000235	putative Zn2+ binding site [ion binding]; other site
402626000236	putative DNA binding site [nucleotide binding]; other site
402626000237	recombination associated protein; Reviewed; Region: rdgC; PRK00321
402626000238	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
402626000239	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
402626000240	hypothetical protein; Provisional; Region: PRK07236
402626000241	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
402626000242	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
402626000243	active site
402626000244	FMN binding site [chemical binding]; other site
402626000245	substrate binding site [chemical binding]; other site
402626000246	homotetramer interface [polypeptide binding]; other site
402626000247	catalytic residue [active]
402626000248	classical (c) SDRs; Region: SDR_c; cd05233
402626000249	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
402626000250	NAD(P) binding site [chemical binding]; other site
402626000251	active site
402626000252	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
402626000253	MarR family; Region: MarR; pfam01047
402626000254	MarR family; Region: MarR_2; cl17246
402626000255	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
402626000256	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626000257	substrate binding site [chemical binding]; other site
402626000258	oxyanion hole (OAH) forming residues; other site
402626000259	trimer interface [polypeptide binding]; other site
402626000260	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626000261	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
402626000262	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626000263	active site
402626000264	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
402626000265	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
402626000266	acyl-activating enzyme (AAE) consensus motif; other site
402626000267	AMP binding site [chemical binding]; other site
402626000268	active site
402626000269	CoA binding site [chemical binding]; other site
402626000270	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
402626000271	active site
402626000272	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
402626000273	homotrimer interaction site [polypeptide binding]; other site
402626000274	putative active site [active]
402626000275	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
402626000276	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626000277	dimerization interface [polypeptide binding]; other site
402626000278	putative DNA binding site [nucleotide binding]; other site
402626000279	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
402626000280	putative Zn2+ binding site [ion binding]; other site
402626000281	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
402626000282	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
402626000283	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
402626000284	classical (c) SDRs; Region: SDR_c; cd05233
402626000285	NAD(P) binding site [chemical binding]; other site
402626000286	active site
402626000287	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626000288	D-galactonate transporter; Region: 2A0114; TIGR00893
402626000289	putative substrate translocation pore; other site
402626000290	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
402626000291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626000292	putative substrate translocation pore; other site
402626000293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626000294	putative substrate translocation pore; other site
402626000295	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
402626000296	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
402626000297	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626000298	DNA-binding site [nucleotide binding]; DNA binding site
402626000299	UTRA domain; Region: UTRA; pfam07702
402626000300	Predicted transcriptional regulators [Transcription]; Region: COG1733
402626000301	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
402626000302	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
402626000303	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
402626000304	Coenzyme A binding pocket [chemical binding]; other site
402626000305	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
402626000306	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626000307	putative metal binding site [ion binding]; other site
402626000308	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626000309	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626000310	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
402626000311	putative dimerization interface [polypeptide binding]; other site
402626000312	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
402626000313	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
402626000314	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626000315	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626000316	putative substrate translocation pore; other site
402626000317	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626000318	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626000319	MoxR-like ATPases [General function prediction only]; Region: COG0714
402626000320	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626000321	Walker A motif; other site
402626000322	ATP binding site [chemical binding]; other site
402626000323	Walker B motif; other site
402626000324	arginine finger; other site
402626000325	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
402626000326	Protein of unknown function DUF58; Region: DUF58; pfam01882
402626000327	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
402626000328	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
402626000329	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
402626000330	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
402626000331	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
402626000332	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
402626000333	substrate binding site [chemical binding]; other site
402626000334	ligand binding site [chemical binding]; other site
402626000335	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
402626000336	substrate binding site [chemical binding]; other site
402626000337	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
402626000338	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
402626000339	dimer interface [polypeptide binding]; other site
402626000340	active site
402626000341	citrylCoA binding site [chemical binding]; other site
402626000342	oxalacetate/citrate binding site [chemical binding]; other site
402626000343	coenzyme A binding site [chemical binding]; other site
402626000344	catalytic triad [active]
402626000345	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
402626000346	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
402626000347	tetramer interface [polypeptide binding]; other site
402626000348	active site
402626000349	Mg2+/Mn2+ binding site [ion binding]; other site
402626000350	Propionate catabolism activator; Region: PrpR_N; pfam06506
402626000351	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
402626000352	PAS domain; Region: PAS; smart00091
402626000353	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626000354	Walker A motif; other site
402626000355	ATP binding site [chemical binding]; other site
402626000356	Walker B motif; other site
402626000357	arginine finger; other site
402626000358	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626000359	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
402626000360	Zn2+ binding site [ion binding]; other site
402626000361	Mg2+ binding site [ion binding]; other site
402626000362	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626000363	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626000364	metal binding site [ion binding]; metal-binding site
402626000365	active site
402626000366	I-site; other site
402626000367	Isochorismatase family; Region: Isochorismatase; pfam00857
402626000368	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
402626000369	catalytic triad [active]
402626000370	conserved cis-peptide bond; other site
402626000371	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
402626000372	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
402626000373	putative ion selectivity filter; other site
402626000374	putative pore gating glutamate residue; other site
402626000375	putative H+/Cl- coupling transport residue; other site
402626000376	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
402626000377	dimer interface [polypeptide binding]; other site
402626000378	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
402626000379	Restriction endonuclease; Region: Mrr_cat; pfam04471
402626000380	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
402626000381	DEAD-like helicases superfamily; Region: DEXDc; smart00487
402626000382	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
402626000383	ATP binding site [chemical binding]; other site
402626000384	putative Mg++ binding site [ion binding]; other site
402626000385	Predicted membrane protein [Function unknown]; Region: COG1289
402626000386	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
402626000387	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
402626000388	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626000389	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
402626000390	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
402626000391	EamA-like transporter family; Region: EamA; pfam00892
402626000392	EamA-like transporter family; Region: EamA; pfam00892
402626000393	enoyl-CoA hydratase; Validated; Region: PRK08139
402626000394	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626000395	substrate binding site [chemical binding]; other site
402626000396	oxyanion hole (OAH) forming residues; other site
402626000397	trimer interface [polypeptide binding]; other site
402626000398	haloalkane dehalogenase; Provisional; Region: PRK00870
402626000399	Predicted transcriptional regulators [Transcription]; Region: COG1733
402626000400	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
402626000401	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
402626000402	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
402626000403	conserved cys residue [active]
402626000404	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626000405	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
402626000406	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
402626000407	conserved cys residue [active]
402626000408	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
402626000409	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
402626000410	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
402626000411	Cytochrome c; Region: Cytochrom_C; cl11414
402626000412	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
402626000413	Cytochrome c; Region: Cytochrom_C; pfam00034
402626000414	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
402626000415	mercuric reductase; Validated; Region: PRK06370
402626000416	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
402626000417	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
402626000418	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
402626000419	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
402626000420	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
402626000421	Spherulation-specific family 4; Region: Spherulin4; pfam12138
402626000422	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626000423	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626000424	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461
402626000425	putative substrate binding pocket [chemical binding]; other site
402626000426	putative dimerization interface [polypeptide binding]; other site
402626000427	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
402626000428	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
402626000429	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
402626000430	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
402626000431	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
402626000432	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
402626000433	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
402626000434	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
402626000435	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
402626000436	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
402626000437	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
402626000438	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
402626000439	Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672
402626000440	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
402626000441	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
402626000442	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
402626000443	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
402626000444	hypothetical protein; Provisional; Region: PRK08201
402626000445	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_1; cd05678
402626000446	putative metal binding site [ion binding]; other site
402626000447	putative dimer interface [polypeptide binding]; other site
402626000448	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626000449	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626000450	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626000451	dimerization interface [polypeptide binding]; other site
402626000452	AMP nucleosidase; Provisional; Region: PRK08292
402626000453	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
402626000454	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
402626000455	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626000456	dimer interface [polypeptide binding]; other site
402626000457	conserved gate region; other site
402626000458	putative PBP binding loops; other site
402626000459	ABC-ATPase subunit interface; other site
402626000460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
402626000461	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626000462	ABC-ATPase subunit interface; other site
402626000463	putative PBP binding loops; other site
402626000464	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
402626000465	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626000466	substrate binding pocket [chemical binding]; other site
402626000467	membrane-bound complex binding site; other site
402626000468	hinge residues; other site
402626000469	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
402626000470	active site
402626000471	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626000472	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626000473	dimer interface [polypeptide binding]; other site
402626000474	phosphorylation site [posttranslational modification]
402626000475	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626000476	ATP binding site [chemical binding]; other site
402626000477	Mg2+ binding site [ion binding]; other site
402626000478	G-X-G motif; other site
402626000479	Methyltransferase domain; Region: Methyltransf_31; pfam13847
402626000480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626000481	S-adenosylmethionine binding site [chemical binding]; other site
402626000482	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
402626000483	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
402626000484	active site
402626000485	benzoate transport; Region: 2A0115; TIGR00895
402626000486	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626000487	putative substrate translocation pore; other site
402626000488	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
402626000489	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
402626000490	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
402626000491	active site
402626000492	catalytic site [active]
402626000493	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
402626000494	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
402626000495	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
402626000496	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
402626000497	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
402626000498	catalytic site [active]
402626000499	active site
402626000500	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
402626000501	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
402626000502	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
402626000503	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
402626000504	active site
402626000505	catalytic site [active]
402626000506	glycogen branching enzyme; Provisional; Region: PRK05402
402626000507	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
402626000508	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
402626000509	active site
402626000510	catalytic site [active]
402626000511	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
402626000512	trehalose synthase; Region: treS_nterm; TIGR02456
402626000513	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
402626000514	active site
402626000515	catalytic site [active]
402626000516	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
402626000517	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
402626000518	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
402626000519	active site
402626000520	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
402626000521	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
402626000522	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
402626000523	active site
402626000524	homodimer interface [polypeptide binding]; other site
402626000525	catalytic site [active]
402626000526	acceptor binding site [chemical binding]; other site
402626000527	glycogen synthase; Provisional; Region: glgA; PRK00654
402626000528	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
402626000529	ADP-binding pocket [chemical binding]; other site
402626000530	homodimer interface [polypeptide binding]; other site
402626000531	peroxiredoxin; Region: AhpC; TIGR03137
402626000532	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
402626000533	dimer interface [polypeptide binding]; other site
402626000534	decamer (pentamer of dimers) interface [polypeptide binding]; other site
402626000535	catalytic triad [active]
402626000536	peroxidatic and resolving cysteines [active]
402626000537	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
402626000538	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
402626000539	catalytic residue [active]
402626000540	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
402626000541	catalytic residues [active]
402626000542	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
402626000543	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
402626000544	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626000545	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626000546	LysR substrate binding domain; Region: LysR_substrate; pfam03466
402626000547	dimerization interface [polypeptide binding]; other site
402626000548	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
402626000549	metal binding site 2 [ion binding]; metal-binding site
402626000550	putative DNA binding helix; other site
402626000551	metal binding site 1 [ion binding]; metal-binding site
402626000552	dimer interface [polypeptide binding]; other site
402626000553	structural Zn2+ binding site [ion binding]; other site
402626000554	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
402626000555	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
402626000556	G1 box; other site
402626000557	GTP/Mg2+ binding site [chemical binding]; other site
402626000558	Switch I region; other site
402626000559	G2 box; other site
402626000560	G3 box; other site
402626000561	Switch II region; other site
402626000562	G4 box; other site
402626000563	G5 box; other site
402626000564	Nucleoside recognition; Region: Gate; pfam07670
402626000565	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
402626000566	Nucleoside recognition; Region: Gate; pfam07670
402626000567	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
402626000568	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626000569	dimerization interface [polypeptide binding]; other site
402626000570	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
402626000571	PAS fold; Region: PAS_3; pfam08447
402626000572	heme pocket [chemical binding]; other site
402626000573	putative active site [active]
402626000574	PAS domain; Region: PAS_9; pfam13426
402626000575	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
402626000576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626000577	PAS domain; Region: PAS_9; pfam13426
402626000578	putative active site [active]
402626000579	heme pocket [chemical binding]; other site
402626000580	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626000581	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626000582	metal binding site [ion binding]; metal-binding site
402626000583	active site
402626000584	I-site; other site
402626000585	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626000586	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626000587	PAS fold; Region: PAS_3; pfam08447
402626000588	putative active site [active]
402626000589	heme pocket [chemical binding]; other site
402626000590	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
402626000591	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626000592	dimer interface [polypeptide binding]; other site
402626000593	putative CheW interface [polypeptide binding]; other site
402626000594	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
402626000595	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
402626000596	FAD binding pocket [chemical binding]; other site
402626000597	FAD binding motif [chemical binding]; other site
402626000598	phosphate binding motif [ion binding]; other site
402626000599	NAD binding pocket [chemical binding]; other site
402626000600	Predicted transcriptional regulators [Transcription]; Region: COG1695
402626000601	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
402626000602	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
402626000603	MarR family; Region: MarR_2; pfam12802
402626000604	Uncharacterized conserved protein [Function unknown]; Region: COG2128
402626000605	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
402626000606	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626000607	Coenzyme A binding pocket [chemical binding]; other site
402626000608	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
402626000609	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
402626000610	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
402626000611	putative substrate binding pocket [chemical binding]; other site
402626000612	AC domain interface; other site
402626000613	catalytic triad [active]
402626000614	AB domain interface; other site
402626000615	interchain disulfide; other site
402626000616	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
402626000617	MarR family; Region: MarR_2; pfam12802
402626000618	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
402626000619	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
402626000620	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
402626000621	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
402626000622	Beta-lactamase; Region: Beta-lactamase; pfam00144
402626000623	Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
402626000624	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
402626000625	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
402626000626	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
402626000627	Walker A/P-loop; other site
402626000628	ATP binding site [chemical binding]; other site
402626000629	Q-loop/lid; other site
402626000630	ABC transporter signature motif; other site
402626000631	Walker B; other site
402626000632	D-loop; other site
402626000633	H-loop/switch region; other site
402626000634	cyanophycin synthetase; Provisional; Region: PRK14016
402626000635	ATP-grasp domain; Region: ATP-grasp_4; cl17255
402626000636	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
402626000637	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
402626000638	cyanophycin synthetase; Provisional; Region: PRK14016
402626000639	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
402626000640	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
402626000641	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
402626000642	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
402626000643	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
402626000644	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626000645	Coenzyme A binding pocket [chemical binding]; other site
402626000646	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
402626000647	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
402626000648	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626000649	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626000650	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626000651	active site
402626000652	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
402626000653	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
402626000654	active site
402626000655	acyl-activating enzyme (AAE) consensus motif; other site
402626000656	putative CoA binding site [chemical binding]; other site
402626000657	AMP binding site [chemical binding]; other site
402626000658	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
402626000659	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
402626000660	tetrameric interface [polypeptide binding]; other site
402626000661	NAD binding site [chemical binding]; other site
402626000662	catalytic residues [active]
402626000663	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
402626000664	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
402626000665	enoyl-CoA hydratase; Provisional; Region: PRK09076
402626000666	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626000667	substrate binding site [chemical binding]; other site
402626000668	oxyanion hole (OAH) forming residues; other site
402626000669	trimer interface [polypeptide binding]; other site
402626000670	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
402626000671	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626000672	substrate binding site [chemical binding]; other site
402626000673	oxyanion hole (OAH) forming residues; other site
402626000674	trimer interface [polypeptide binding]; other site
402626000675	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
402626000676	Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172
402626000677	PLD-like domain; Region: PLDc_2; pfam13091
402626000678	putative active site [active]
402626000679	catalytic site [active]
402626000680	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
402626000681	PLD-like domain; Region: PLDc_2; pfam13091
402626000682	putative active site [active]
402626000683	catalytic site [active]
402626000684	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
402626000685	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
402626000686	acyl-activating enzyme (AAE) consensus motif; other site
402626000687	putative AMP binding site [chemical binding]; other site
402626000688	putative active site [active]
402626000689	putative CoA binding site [chemical binding]; other site
402626000690	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
402626000691	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
402626000692	putative Cl- selectivity filter; other site
402626000693	putative pore gating glutamate residue; other site
402626000694	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
402626000695	Transcriptional regulator [Transcription]; Region: IclR; COG1414
402626000696	hypothetical protein; Validated; Region: PRK06201
402626000697	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
402626000698	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
402626000699	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
402626000700	ligand binding site [chemical binding]; other site
402626000701	NAD binding site [chemical binding]; other site
402626000702	dimerization interface [polypeptide binding]; other site
402626000703	catalytic site [active]
402626000704	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
402626000705	Strictosidine synthase; Region: Str_synth; pfam03088
402626000706	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
402626000707	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626000708	putative substrate translocation pore; other site
402626000709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626000710	putative substrate translocation pore; other site
402626000711	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
402626000712	active site
402626000713	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
402626000714	active site
402626000715	catalytic residues [active]
402626000716	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
402626000717	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
402626000718	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626000719	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626000720	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626000721	metal binding site [ion binding]; metal-binding site
402626000722	active site
402626000723	I-site; other site
402626000724	Predicted integral membrane protein [Function unknown]; Region: COG0392
402626000725	Uncharacterized conserved protein [Function unknown]; Region: COG2898
402626000726	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
402626000727	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
402626000728	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
402626000729	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
402626000730	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
402626000731	Sulfate transporter family; Region: Sulfate_transp; pfam00916
402626000732	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
402626000733	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
402626000734	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
402626000735	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626000736	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626000737	dimerization interface [polypeptide binding]; other site
402626000738	short chain dehydrogenase; Provisional; Region: PRK06500
402626000739	classical (c) SDRs; Region: SDR_c; cd05233
402626000740	NAD(P) binding site [chemical binding]; other site
402626000741	active site
402626000742	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
402626000743	YheO-like PAS domain; Region: PAS_6; pfam08348
402626000744	HTH domain; Region: HTH_22; pfam13309
402626000745	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
402626000746	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
402626000747	tetramer interface [polypeptide binding]; other site
402626000748	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626000749	catalytic residue [active]
402626000750	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
402626000751	homotrimer interaction site [polypeptide binding]; other site
402626000752	putative active site [active]
402626000753	Flagellar protein YcgR; Region: YcgR_2; pfam12945
402626000754	PilZ domain; Region: PilZ; pfam07238
402626000755	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626000756	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626000757	LysR substrate binding domain; Region: LysR_substrate; pfam03466
402626000758	dimerization interface [polypeptide binding]; other site
402626000759	Predicted membrane protein [Function unknown]; Region: COG4125
402626000760	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
402626000761	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
402626000762	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626000763	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626000764	DNA binding residues [nucleotide binding]
402626000765	dimerization interface [polypeptide binding]; other site
402626000766	Protein of unknown function (DUF1059); Region: DUF1059; cl02284
402626000767	Protein of unknown function, DUF488; Region: DUF488; cl01246
402626000768	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
402626000769	NMT1-like family; Region: NMT1_2; pfam13379
402626000770	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
402626000771	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626000772	putative PBP binding loops; other site
402626000773	ABC-ATPase subunit interface; other site
402626000774	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
402626000775	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
402626000776	Walker A/P-loop; other site
402626000777	ATP binding site [chemical binding]; other site
402626000778	Q-loop/lid; other site
402626000779	ABC transporter signature motif; other site
402626000780	Walker B; other site
402626000781	D-loop; other site
402626000782	H-loop/switch region; other site
402626000783	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
402626000784	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626000785	DNA-binding site [nucleotide binding]; DNA binding site
402626000786	UTRA domain; Region: UTRA; pfam07702
402626000787	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
402626000788	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
402626000789	Binuclear center (active site) [active]
402626000790	K-pathway; other site
402626000791	Putative proton exit pathway; other site
402626000792	Putative water exit pathway; other site
402626000793	Uncharacterized conserved protein [Function unknown]; Region: COG4309
402626000794	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
402626000795	Multicopper oxidase; Region: Cu-oxidase; pfam00394
402626000796	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
402626000797	Cytochrome c; Region: Cytochrom_C; pfam00034
402626000798	Uncharacterized conserved protein [Function unknown]; Region: COG1262
402626000799	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
402626000800	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
402626000801	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
402626000802	Cu(I) binding site [ion binding]; other site
402626000803	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
402626000804	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
402626000805	Transcriptional regulators [Transcription]; Region: GntR; COG1802
402626000806	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626000807	DNA-binding site [nucleotide binding]; DNA binding site
402626000808	FCD domain; Region: FCD; pfam07729
402626000809	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626000810	D-galactonate transporter; Region: 2A0114; TIGR00893
402626000811	putative substrate translocation pore; other site
402626000812	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
402626000813	dihydropyrimidinase; Provisional; Region: PRK13404
402626000814	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
402626000815	tetramer interface [polypeptide binding]; other site
402626000816	active site
402626000817	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
402626000818	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
402626000819	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
402626000820	ligand binding site [chemical binding]; other site
402626000821	flexible hinge region; other site
402626000822	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
402626000823	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
402626000824	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
402626000825	putative catalytic residue [active]
402626000826	Coenzyme A transferase; Region: CoA_trans; cl17247
402626000827	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
402626000828	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
402626000829	Predicted flavoprotein [General function prediction only]; Region: COG0431
402626000830	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
402626000831	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
402626000832	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
402626000833	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
402626000834	Predicted periplasmic protein [Function unknown]; Region: COG3904
402626000835	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
402626000836	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
402626000837	Walker A/P-loop; other site
402626000838	ATP binding site [chemical binding]; other site
402626000839	Q-loop/lid; other site
402626000840	ABC transporter signature motif; other site
402626000841	Walker B; other site
402626000842	D-loop; other site
402626000843	H-loop/switch region; other site
402626000844	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
402626000845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626000846	dimer interface [polypeptide binding]; other site
402626000847	conserved gate region; other site
402626000848	putative PBP binding loops; other site
402626000849	ABC-ATPase subunit interface; other site
402626000850	NMT1/THI5 like; Region: NMT1; pfam09084
402626000851	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626000852	substrate binding pocket [chemical binding]; other site
402626000853	membrane-bound complex binding site; other site
402626000854	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
402626000855	Transcriptional regulator [Transcription]; Region: IclR; COG1414
402626000856	Bacterial transcriptional regulator; Region: IclR; pfam01614
402626000857	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
402626000858	CoA-transferase family III; Region: CoA_transf_3; pfam02515
402626000859	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
402626000860	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
402626000861	active site
402626000862	citrylCoA binding site [chemical binding]; other site
402626000863	oxalacetate binding site [chemical binding]; other site
402626000864	coenzyme A binding site [chemical binding]; other site
402626000865	catalytic triad [active]
402626000866	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
402626000867	Strictosidine synthase; Region: Str_synth; pfam03088
402626000868	transcriptional activator FlhD; Provisional; Region: PRK02909
402626000869	transcriptional activator FlhC; Provisional; Region: PRK12722
402626000870	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
402626000871	flagellar motor protein MotA; Validated; Region: PRK09110
402626000872	flagellar motor protein MotB; Validated; Region: motB; PRK09041
402626000873	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
402626000874	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
402626000875	ligand binding site [chemical binding]; other site
402626000876	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
402626000877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626000878	active site
402626000879	phosphorylation site [posttranslational modification]
402626000880	intermolecular recognition site; other site
402626000881	dimerization interface [polypeptide binding]; other site
402626000882	chemotaxis protein CheA; Provisional; Region: PRK10547
402626000883	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
402626000884	putative binding surface; other site
402626000885	active site
402626000886	CheY binding; Region: CheY-binding; pfam09078
402626000887	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
402626000888	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626000889	ATP binding site [chemical binding]; other site
402626000890	Mg2+ binding site [ion binding]; other site
402626000891	G-X-G motif; other site
402626000892	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
402626000893	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
402626000894	putative CheA interaction surface; other site
402626000895	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
402626000896	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
402626000897	dimer interface [polypeptide binding]; other site
402626000898	ligand binding site [chemical binding]; other site
402626000899	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626000900	dimerization interface [polypeptide binding]; other site
402626000901	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626000902	dimer interface [polypeptide binding]; other site
402626000903	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
402626000904	putative CheW interface [polypeptide binding]; other site
402626000905	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626000906	dimer interface [polypeptide binding]; other site
402626000907	putative CheW interface [polypeptide binding]; other site
402626000908	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
402626000909	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
402626000910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626000911	CheD chemotactic sensory transduction; Region: CheD; cl00810
402626000912	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
402626000913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626000914	active site
402626000915	phosphorylation site [posttranslational modification]
402626000916	intermolecular recognition site; other site
402626000917	dimerization interface [polypeptide binding]; other site
402626000918	CheB methylesterase; Region: CheB_methylest; pfam01339
402626000919	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
402626000920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626000921	active site
402626000922	phosphorylation site [posttranslational modification]
402626000923	intermolecular recognition site; other site
402626000924	dimerization interface [polypeptide binding]; other site
402626000925	chemotaxis regulator CheZ; Provisional; Region: PRK11166
402626000926	ApbE family; Region: ApbE; pfam02424
402626000927	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
402626000928	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
402626000929	nitrous-oxide reductase; Validated; Region: PRK02888
402626000930	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
402626000931	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
402626000932	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
402626000933	4Fe-4S binding domain; Region: Fer4_5; pfam12801
402626000934	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
402626000935	Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420
402626000936	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
402626000937	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
402626000938	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
402626000939	Walker A/P-loop; other site
402626000940	ATP binding site [chemical binding]; other site
402626000941	Q-loop/lid; other site
402626000942	ABC transporter signature motif; other site
402626000943	Walker B; other site
402626000944	D-loop; other site
402626000945	H-loop/switch region; other site
402626000946	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
402626000947	NosL; Region: NosL; pfam05573
402626000948	NosL; Region: NosL; cl01769
402626000949	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
402626000950	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
402626000951	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
402626000952	FHIPEP family; Region: FHIPEP; pfam00771
402626000953	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
402626000954	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
402626000955	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
402626000956	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
402626000957	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
402626000958	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
402626000959	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
402626000960	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
402626000961	DNA binding residues [nucleotide binding]
402626000962	xanthine permease; Region: pbuX; TIGR03173
402626000963	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
402626000964	active site
402626000965	catalytic residues [active]
402626000966	Transcriptional regulators [Transcription]; Region: PurR; COG1609
402626000967	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
402626000968	putative dimerization interface [polypeptide binding]; other site
402626000969	putative ligand binding site [chemical binding]; other site
402626000970	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
402626000971	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626000972	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
402626000973	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
402626000974	putative ligand binding site [chemical binding]; other site
402626000975	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
402626000976	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
402626000977	Walker A/P-loop; other site
402626000978	ATP binding site [chemical binding]; other site
402626000979	Q-loop/lid; other site
402626000980	ABC transporter signature motif; other site
402626000981	Walker B; other site
402626000982	D-loop; other site
402626000983	H-loop/switch region; other site
402626000984	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
402626000985	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626000986	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
402626000987	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
402626000988	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626000989	TM-ABC transporter signature motif; other site
402626000990	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
402626000991	classical (c) SDRs; Region: SDR_c; cd05233
402626000992	NAD(P) binding site [chemical binding]; other site
402626000993	active site
402626000994	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
402626000995	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
402626000996	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
402626000997	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
402626000998	Transcriptional regulator [Transcription]; Region: IclR; COG1414
402626000999	Bacterial transcriptional regulator; Region: IclR; pfam01614
402626001000	Transcriptional regulators [Transcription]; Region: PurR; COG1609
402626001001	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
402626001002	DNA binding site [nucleotide binding]
402626001003	domain linker motif; other site
402626001004	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
402626001005	putative dimerization interface [polypeptide binding]; other site
402626001006	putative ligand binding site [chemical binding]; other site
402626001007	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
402626001008	Isochorismatase family; Region: Isochorismatase; pfam00857
402626001009	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
402626001010	catalytic triad [active]
402626001011	conserved cis-peptide bond; other site
402626001012	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
402626001013	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
402626001014	conserved cys residue [active]
402626001015	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626001016	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626001017	YGGT family; Region: YGGT; pfam02325
402626001018	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
402626001019	substrate binding site [chemical binding]; other site
402626001020	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
402626001021	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626001022	substrate binding pocket [chemical binding]; other site
402626001023	membrane-bound complex binding site; other site
402626001024	hinge residues; other site
402626001025	Protein of unknown function (DUF971); Region: DUF971; pfam06155
402626001026	HEAT repeats; Region: HEAT_2; pfam13646
402626001027	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
402626001028	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
402626001029	putative oxidoreductase; Provisional; Region: PRK08275
402626001030	L-aspartate oxidase; Provisional; Region: PRK06175
402626001031	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
402626001032	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
402626001033	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626001034	DNA-binding site [nucleotide binding]; DNA binding site
402626001035	UTRA domain; Region: UTRA; pfam07702
402626001036	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
402626001037	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
402626001038	putative ligand binding site [chemical binding]; other site
402626001039	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
402626001040	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
402626001041	Walker A/P-loop; other site
402626001042	ATP binding site [chemical binding]; other site
402626001043	Q-loop/lid; other site
402626001044	ABC transporter signature motif; other site
402626001045	Walker B; other site
402626001046	D-loop; other site
402626001047	H-loop/switch region; other site
402626001048	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
402626001049	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626001050	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
402626001051	TM-ABC transporter signature motif; other site
402626001052	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626001053	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
402626001054	TM-ABC transporter signature motif; other site
402626001055	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
402626001056	Dehydroquinase class II; Region: DHquinase_II; pfam01220
402626001057	trimer interface [polypeptide binding]; other site
402626001058	active site
402626001059	dimer interface [polypeptide binding]; other site
402626001060	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
402626001061	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
402626001062	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
402626001063	RibD C-terminal domain; Region: RibD_C; cl17279
402626001064	recombination associated protein; Reviewed; Region: rdgC; PRK00321
402626001065	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
402626001066	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
402626001067	homodimer interface [polypeptide binding]; other site
402626001068	substrate-cofactor binding pocket; other site
402626001069	catalytic residue [active]
402626001070	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
402626001071	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
402626001072	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
402626001073	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
402626001074	Fatty acid desaturase; Region: FA_desaturase; pfam00487
402626001075	Di-iron ligands [ion binding]; other site
402626001076	Cupin domain; Region: Cupin_2; cl17218
402626001077	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626001078	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
402626001079	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
402626001080	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626001081	NAD(P) binding site [chemical binding]; other site
402626001082	active site
402626001083	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
402626001084	substrate binding site [chemical binding]; other site
402626001085	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
402626001086	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
402626001087	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
402626001088	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
402626001089	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
402626001090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626001091	Predicted membrane protein [Function unknown]; Region: COG3766
402626001092	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
402626001093	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
402626001094	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
402626001095	Short C-terminal domain; Region: SHOCT; pfam09851
402626001096	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
402626001097	Double zinc ribbon; Region: DZR; pfam12773
402626001098	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
402626001099	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675
402626001100	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
402626001101	GAF domain; Region: GAF; pfam01590
402626001102	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626001103	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626001104	metal binding site [ion binding]; metal-binding site
402626001105	active site
402626001106	I-site; other site
402626001107	fumarate hydratase; Reviewed; Region: fumC; PRK00485
402626001108	Class II fumarases; Region: Fumarase_classII; cd01362
402626001109	active site
402626001110	tetramer interface [polypeptide binding]; other site
402626001111	putative transporter; Provisional; Region: PRK10504
402626001112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626001113	putative substrate translocation pore; other site
402626001114	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
402626001115	Part of AAA domain; Region: AAA_19; pfam13245
402626001116	Family description; Region: UvrD_C_2; pfam13538
402626001117	hypothetical protein; Provisional; Region: PRK02237
402626001118	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
402626001119	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
402626001120	ATP binding site [chemical binding]; other site
402626001121	substrate binding site [chemical binding]; other site
402626001122	TraB family; Region: TraB; pfam01963
402626001123	AAA domain; Region: AAA_14; pfam13173
402626001124	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
402626001125	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
402626001126	N-terminal plug; other site
402626001127	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
402626001128	ligand-binding site [chemical binding]; other site
402626001129	BNR repeat-like domain; Region: BNR_2; pfam13088
402626001130	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
402626001131	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
402626001132	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
402626001133	hypothetical protein; Provisional; Region: PRK10621
402626001134	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626001135	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626001136	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
402626001137	putative dimerization interface [polypeptide binding]; other site
402626001138	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
402626001139	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
402626001140	active site
402626001141	acyl-activating enzyme (AAE) consensus motif; other site
402626001142	putative CoA binding site [chemical binding]; other site
402626001143	AMP binding site [chemical binding]; other site
402626001144	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
402626001145	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
402626001146	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
402626001147	LysR family transcriptional regulator; Provisional; Region: PRK14997
402626001148	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626001149	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
402626001150	putative effector binding pocket; other site
402626001151	putative dimerization interface [polypeptide binding]; other site
402626001152	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626001153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626001154	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626001155	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
402626001156	PGDYG protein; Region: PGDYG; pfam14083
402626001157	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
402626001158	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
402626001159	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
402626001160	Predicted transcriptional regulators [Transcription]; Region: COG1510
402626001161	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626001162	dimerization interface [polypeptide binding]; other site
402626001163	putative DNA binding site [nucleotide binding]; other site
402626001164	putative Zn2+ binding site [ion binding]; other site
402626001165	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
402626001166	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626001167	putative substrate translocation pore; other site
402626001168	nitrite reductase subunit NirD; Provisional; Region: PRK14989
402626001169	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
402626001170	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
402626001171	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
402626001172	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
402626001173	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
402626001174	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
402626001175	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
402626001176	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
402626001177	[4Fe-4S] binding site [ion binding]; other site
402626001178	molybdopterin cofactor binding site; other site
402626001179	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
402626001180	molybdopterin cofactor binding site; other site
402626001181	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
402626001182	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
402626001183	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
402626001184	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
402626001185	H+ Antiporter protein; Region: 2A0121; TIGR00900
402626001186	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
402626001187	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
402626001188	putative active site [active]
402626001189	catalytic site [active]
402626001190	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
402626001191	putative active site [active]
402626001192	catalytic site [active]
402626001193	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
402626001194	PLD-like domain; Region: PLDc_2; pfam13091
402626001195	putative active site [active]
402626001196	catalytic site [active]
402626001197	Protein of unknown function (DUF3729); Region: DUF3729; pfam12526
402626001198	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
402626001199	PLD-like domain; Region: PLDc_2; pfam13091
402626001200	putative active site [active]
402626001201	catalytic site [active]
402626001202	Entericidin EcnA/B family; Region: Entericidin; pfam08085
402626001203	Tar ligand binding domain homologue; Region: TarH; pfam02203
402626001204	dimer interface [polypeptide binding]; other site
402626001205	ligand binding site [chemical binding]; other site
402626001206	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626001207	dimerization interface [polypeptide binding]; other site
402626001208	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626001209	dimer interface [polypeptide binding]; other site
402626001210	putative CheW interface [polypeptide binding]; other site
402626001211	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626001212	metal binding site [ion binding]; metal-binding site
402626001213	active site
402626001214	I-site; other site
402626001215	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626001216	Flagellar protein YcgR; Region: YcgR_2; pfam12945
402626001217	PilZ domain; Region: PilZ; pfam07238
402626001218	Predicted membrane protein [Function unknown]; Region: COG2246
402626001219	GtrA-like protein; Region: GtrA; pfam04138
402626001220	PAS domain S-box; Region: sensory_box; TIGR00229
402626001221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626001222	putative active site [active]
402626001223	heme pocket [chemical binding]; other site
402626001224	PAS fold; Region: PAS_3; pfam08447
402626001225	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626001226	putative active site [active]
402626001227	heme pocket [chemical binding]; other site
402626001228	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626001229	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626001230	metal binding site [ion binding]; metal-binding site
402626001231	active site
402626001232	I-site; other site
402626001233	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
402626001234	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
402626001235	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
402626001236	Protein export membrane protein; Region: SecD_SecF; cl14618
402626001237	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
402626001238	Protein export membrane protein; Region: SecD_SecF; cl14618
402626001239	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626001240	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626001241	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
402626001242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626001243	active site
402626001244	phosphorylation site [posttranslational modification]
402626001245	intermolecular recognition site; other site
402626001246	dimerization interface [polypeptide binding]; other site
402626001247	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626001248	DNA binding site [nucleotide binding]
402626001249	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
402626001250	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626001251	dimer interface [polypeptide binding]; other site
402626001252	phosphorylation site [posttranslational modification]
402626001253	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626001254	ATP binding site [chemical binding]; other site
402626001255	Mg2+ binding site [ion binding]; other site
402626001256	G-X-G motif; other site
402626001257	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
402626001258	Domain of unknown function (DUF333); Region: DUF333; pfam03891
402626001259	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
402626001260	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
402626001261	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
402626001262	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
402626001263	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
402626001264	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
402626001265	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
402626001266	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
402626001267	active site
402626001268	intersubunit interface [polypeptide binding]; other site
402626001269	catalytic residue [active]
402626001270	GntP family permease; Region: GntP_permease; pfam02447
402626001271	fructuronate transporter; Provisional; Region: PRK10034; cl15264
402626001272	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
402626001273	homotrimer interaction site [polypeptide binding]; other site
402626001274	putative active site [active]
402626001275	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
402626001276	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
402626001277	active site
402626001278	putative substrate binding pocket [chemical binding]; other site
402626001279	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
402626001280	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
402626001281	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
402626001282	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
402626001283	putative active site [active]
402626001284	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
402626001285	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
402626001286	dimer interface [polypeptide binding]; other site
402626001287	active site
402626001288	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
402626001289	substrate binding site [chemical binding]; other site
402626001290	catalytic residue [active]
402626001291	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
402626001292	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
402626001293	substrate binding site [chemical binding]; other site
402626001294	ATP binding site [chemical binding]; other site
402626001295	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
402626001296	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
402626001297	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
402626001298	active site
402626001299	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626001300	PAS domain; Region: PAS_9; pfam13426
402626001301	putative active site [active]
402626001302	heme pocket [chemical binding]; other site
402626001303	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626001304	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626001305	dimer interface [polypeptide binding]; other site
402626001306	phosphorylation site [posttranslational modification]
402626001307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626001308	ATP binding site [chemical binding]; other site
402626001309	Mg2+ binding site [ion binding]; other site
402626001310	G-X-G motif; other site
402626001311	Response regulator receiver domain; Region: Response_reg; pfam00072
402626001312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626001313	active site
402626001314	phosphorylation site [posttranslational modification]
402626001315	intermolecular recognition site; other site
402626001316	dimerization interface [polypeptide binding]; other site
402626001317	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626001318	H+ Antiporter protein; Region: 2A0121; TIGR00900
402626001319	putative substrate translocation pore; other site
402626001320	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
402626001321	Dodecin; Region: Dodecin; pfam07311
402626001322	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
402626001323	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
402626001324	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
402626001325	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
402626001326	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
402626001327	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
402626001328	Transporter associated domain; Region: CorC_HlyC; pfam03471
402626001329	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
402626001330	EamA-like transporter family; Region: EamA; pfam00892
402626001331	EamA-like transporter family; Region: EamA; pfam00892
402626001332	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
402626001333	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
402626001334	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626001335	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626001336	dimerization interface [polypeptide binding]; other site
402626001337	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626001338	dimer interface [polypeptide binding]; other site
402626001339	phosphorylation site [posttranslational modification]
402626001340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626001341	ATP binding site [chemical binding]; other site
402626001342	Mg2+ binding site [ion binding]; other site
402626001343	G-X-G motif; other site
402626001344	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
402626001345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626001346	active site
402626001347	phosphorylation site [posttranslational modification]
402626001348	intermolecular recognition site; other site
402626001349	dimerization interface [polypeptide binding]; other site
402626001350	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626001351	DNA binding site [nucleotide binding]
402626001352	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
402626001353	dimer interface [polypeptide binding]; other site
402626001354	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
402626001355	Ligand Binding Site [chemical binding]; other site
402626001356	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
402626001357	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626001358	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
402626001359	PAS domain S-box; Region: sensory_box; TIGR00229
402626001360	PAS domain; Region: PAS; smart00091
402626001361	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626001362	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626001363	metal binding site [ion binding]; metal-binding site
402626001364	active site
402626001365	I-site; other site
402626001366	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626001367	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
402626001368	molybdenum-pterin binding domain; Region: Mop; TIGR00638
402626001369	TOBE domain; Region: TOBE; cl01440
402626001370	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
402626001371	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
402626001372	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626001373	Walker A/P-loop; other site
402626001374	ATP binding site [chemical binding]; other site
402626001375	ABC transporter; Region: ABC_tran; pfam00005
402626001376	Q-loop/lid; other site
402626001377	AAA domain; Region: AAA_21; pfam13304
402626001378	ABC transporter signature motif; other site
402626001379	Walker B; other site
402626001380	D-loop; other site
402626001381	H-loop/switch region; other site
402626001382	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
402626001383	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626001384	putative PBP binding loops; other site
402626001385	dimer interface [polypeptide binding]; other site
402626001386	ABC-ATPase subunit interface; other site
402626001387	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
402626001388	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
402626001389	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626001390	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
402626001391	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626001392	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
402626001393	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626001394	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626001395	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
402626001396	putative effector binding pocket; other site
402626001397	putative dimerization interface [polypeptide binding]; other site
402626001398	Predicted secreted protein [Function unknown]; Region: COG5445
402626001399	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
402626001400	Uncharacterized conserved protein [Function unknown]; Region: COG1656
402626001401	Protein of unknown function DUF82; Region: DUF82; pfam01927
402626001402	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
402626001403	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
402626001404	active site
402626001405	homotetramer interface [polypeptide binding]; other site
402626001406	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
402626001407	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
402626001408	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
402626001409	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
402626001410	active site
402626001411	FMN binding site [chemical binding]; other site
402626001412	2,4-decadienoyl-CoA binding site; other site
402626001413	catalytic residue [active]
402626001414	4Fe-4S cluster binding site [ion binding]; other site
402626001415	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
402626001416	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
402626001417	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
402626001418	active site
402626001419	Int/Topo IB signature motif; other site
402626001420	catalytic residues [active]
402626001421	DNA binding site [nucleotide binding]
402626001422	UDP-glucose 4-epimerase; Region: PLN02240
402626001423	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
402626001424	NAD binding site [chemical binding]; other site
402626001425	homodimer interface [polypeptide binding]; other site
402626001426	active site
402626001427	substrate binding site [chemical binding]; other site
402626001428	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626001429	putative active site [active]
402626001430	PAS fold; Region: PAS_3; pfam08447
402626001431	heme pocket [chemical binding]; other site
402626001432	Cache domain; Region: Cache_2; pfam08269
402626001433	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626001434	dimer interface [polypeptide binding]; other site
402626001435	putative CheW interface [polypeptide binding]; other site
402626001436	H-NS histone family; Region: Histone_HNS; pfam00816
402626001437	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
402626001438	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626001439	metal binding site [ion binding]; metal-binding site
402626001440	active site
402626001441	I-site; other site
402626001442	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626001443	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626001444	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626001445	DNA binding residues [nucleotide binding]
402626001446	dimerization interface [polypeptide binding]; other site
402626001447	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
402626001448	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
402626001449	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
402626001450	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
402626001451	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
402626001452	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
402626001453	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
402626001454	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
402626001455	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
402626001456	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
402626001457	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
402626001458	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
402626001459	ATP binding site [chemical binding]; other site
402626001460	Walker A motif; other site
402626001461	hexamer interface [polypeptide binding]; other site
402626001462	Walker B motif; other site
402626001463	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
402626001464	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
402626001465	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
402626001466	TPR repeat; Region: TPR_11; pfam13414
402626001467	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
402626001468	binding surface
402626001469	TPR motif; other site
402626001470	Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
402626001471	Predicted membrane protein [Function unknown]; Region: COG4655
402626001472	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
402626001473	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626001474	Walker A motif; other site
402626001475	ATP binding site [chemical binding]; other site
402626001476	Walker B motif; other site
402626001477	arginine finger; other site
402626001478	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626001479	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
402626001480	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
402626001481	Cytochrome P450; Region: p450; pfam00067
402626001482	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
402626001483	Flavodoxin; Region: Flavodoxin_1; pfam00258
402626001484	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
402626001485	FAD binding pocket [chemical binding]; other site
402626001486	FAD binding motif [chemical binding]; other site
402626001487	catalytic residues [active]
402626001488	NAD binding pocket [chemical binding]; other site
402626001489	phosphate binding motif [ion binding]; other site
402626001490	beta-alpha-beta structure motif; other site
402626001491	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
402626001492	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
402626001493	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
402626001494	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
402626001495	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
402626001496	Cytochrome P450; Region: p450; cl12078
402626001497	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626001498	dimerization interface [polypeptide binding]; other site
402626001499	putative DNA binding site [nucleotide binding]; other site
402626001500	putative Zn2+ binding site [ion binding]; other site
402626001501	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
402626001502	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
402626001503	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
402626001504	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
402626001505	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
402626001506	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
402626001507	N-terminal plug; other site
402626001508	ligand-binding site [chemical binding]; other site
402626001509	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
402626001510	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
402626001511	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
402626001512	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
402626001513	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
402626001514	active site
402626001515	nucleophile elbow; other site
402626001516	Patatin phospholipase; Region: DUF3734; pfam12536
402626001517	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
402626001518	classical (c) SDRs; Region: SDR_c; cd05233
402626001519	NAD(P) binding site [chemical binding]; other site
402626001520	active site
402626001521	acetoacetate decarboxylase; Provisional; Region: PRK02265
402626001522	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
402626001523	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626001524	DNA-binding site [nucleotide binding]; DNA binding site
402626001525	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626001526	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626001527	homodimer interface [polypeptide binding]; other site
402626001528	catalytic residue [active]
402626001529	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
402626001530	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
402626001531	inhibitor-cofactor binding pocket; inhibition site
402626001532	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626001533	catalytic residue [active]
402626001534	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
402626001535	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
402626001536	tetrameric interface [polypeptide binding]; other site
402626001537	NAD binding site [chemical binding]; other site
402626001538	catalytic residues [active]
402626001539	Cold shock proteins [Transcription]; Region: CspC; COG1278
402626001540	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
402626001541	DNA-binding site [nucleotide binding]; DNA binding site
402626001542	RNA-binding motif; other site
402626001543	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
402626001544	potassium uptake protein; Region: kup; TIGR00794
402626001545	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
402626001546	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
402626001547	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
402626001548	putative molybdopterin cofactor binding site [chemical binding]; other site
402626001549	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
402626001550	putative molybdopterin cofactor binding site; other site
402626001551	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
402626001552	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626001553	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
402626001554	putative binding surface; other site
402626001555	active site
402626001556	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
402626001557	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626001558	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626001559	Outer membrane efflux protein; Region: OEP; pfam02321
402626001560	Outer membrane efflux protein; Region: OEP; pfam02321
402626001561	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
402626001562	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
402626001563	DNA binding residues [nucleotide binding]
402626001564	bacterial OsmY and nodulation domain; Region: BON; smart00749
402626001565	Predicted membrane protein [Function unknown]; Region: COG2259
402626001566	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
402626001567	hypothetical protein; Provisional; Region: PRK05409
402626001568	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
402626001569	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
402626001570	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
402626001571	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
402626001572	EamA-like transporter family; Region: EamA; pfam00892
402626001573	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
402626001574	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
402626001575	AsnC family; Region: AsnC_trans_reg; pfam01037
402626001576	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
402626001577	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
402626001578	AsnC family; Region: AsnC_trans_reg; pfam01037
402626001579	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
402626001580	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
402626001581	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
402626001582	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
402626001583	dimer interface [polypeptide binding]; other site
402626001584	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
402626001585	active site
402626001586	Fe binding site [ion binding]; other site
402626001587	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
402626001588	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626001589	putative substrate translocation pore; other site
402626001590	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
402626001591	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
402626001592	NAD(P) binding site [chemical binding]; other site
402626001593	shikimate binding site; other site
402626001594	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626001595	metabolite-proton symporter; Region: 2A0106; TIGR00883
402626001596	putative substrate translocation pore; other site
402626001597	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
402626001598	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
402626001599	Bacterial transcriptional regulator; Region: IclR; pfam01614
402626001600	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
402626001601	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
402626001602	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
402626001603	dimer interface [polypeptide binding]; other site
402626001604	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
402626001605	active site
402626001606	Fe binding site [ion binding]; other site
402626001607	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626001608	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626001609	trimer interface [polypeptide binding]; other site
402626001610	eyelet of channel; other site
402626001611	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
402626001612	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
402626001613	hydroxyglutarate oxidase; Provisional; Region: PRK11728
402626001614	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
402626001615	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
402626001616	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
402626001617	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
402626001618	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
402626001619	Chromate transporter; Region: Chromate_transp; pfam02417
402626001620	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
402626001621	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
402626001622	ATP binding site [chemical binding]; other site
402626001623	Mg++ binding site [ion binding]; other site
402626001624	motif III; other site
402626001625	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
402626001626	nucleotide binding region [chemical binding]; other site
402626001627	ATP-binding site [chemical binding]; other site
402626001628	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
402626001629	putative RNA binding site [nucleotide binding]; other site
402626001630	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
402626001631	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
402626001632	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
402626001633	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
402626001634	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
402626001635	dimer interaction site [polypeptide binding]; other site
402626001636	substrate-binding tunnel; other site
402626001637	active site
402626001638	catalytic site [active]
402626001639	substrate binding site [chemical binding]; other site
402626001640	phosphate acetyltransferase; Provisional; Region: PRK11890
402626001641	propionate/acetate kinase; Provisional; Region: PRK12379
402626001642	Acetokinase family; Region: Acetate_kinase; cl17229
402626001643	succinic semialdehyde dehydrogenase; Region: PLN02278
402626001644	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
402626001645	tetramerization interface [polypeptide binding]; other site
402626001646	NAD(P) binding site [chemical binding]; other site
402626001647	catalytic residues [active]
402626001648	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
402626001649	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
402626001650	putative active site [active]
402626001651	metal binding site [ion binding]; metal-binding site
402626001652	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
402626001653	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
402626001654	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
402626001655	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
402626001656	substrate binding pocket [chemical binding]; other site
402626001657	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
402626001658	homotrimer interaction site [polypeptide binding]; other site
402626001659	putative active site [active]
402626001660	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
402626001661	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
402626001662	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
402626001663	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
402626001664	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
402626001665	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626001666	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626001667	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
402626001668	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626001669	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626001670	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
402626001671	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
402626001672	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
402626001673	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
402626001674	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
402626001675	hydroxyglutarate oxidase; Provisional; Region: PRK11728
402626001676	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
402626001677	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
402626001678	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
402626001679	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
402626001680	Int/Topo IB signature motif; other site
402626001681	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
402626001682	Predicted transcriptional regulator [Transcription]; Region: COG3905
402626001683	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
402626001684	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
402626001685	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
402626001686	Zonular occludens toxin (Zot); Region: Zot; cl17485
402626001687	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
402626001688	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
402626001689	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
402626001690	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
402626001691	DNA binding residues [nucleotide binding]
402626001692	classical (c) SDRs; Region: SDR_c; cd05233
402626001693	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
402626001694	NAD(P) binding site [chemical binding]; other site
402626001695	active site
402626001696	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
402626001697	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
402626001698	Iron-sulfur protein interface; other site
402626001699	proximal quinone binding site [chemical binding]; other site
402626001700	SdhD (CybS) interface [polypeptide binding]; other site
402626001701	proximal heme binding site [chemical binding]; other site
402626001702	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
402626001703	SdhC subunit interface [polypeptide binding]; other site
402626001704	proximal heme binding site [chemical binding]; other site
402626001705	cardiolipin binding site; other site
402626001706	Iron-sulfur protein interface; other site
402626001707	proximal quinone binding site [chemical binding]; other site
402626001708	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
402626001709	L-aspartate oxidase; Provisional; Region: PRK06175
402626001710	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
402626001711	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
402626001712	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
402626001713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
402626001714	Anti-sigma-K factor rskA; Region: RskA; pfam10099
402626001715	RNA polymerase sigma factor; Provisional; Region: PRK12514
402626001716	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
402626001717	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
402626001718	DNA binding residues [nucleotide binding]
402626001719	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
402626001720	Fasciclin domain; Region: Fasciclin; pfam02469
402626001721	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
402626001722	heme-binding site [chemical binding]; other site
402626001723	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626001724	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
402626001725	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
402626001726	FtsX-like permease family; Region: FtsX; pfam02687
402626001727	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
402626001728	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
402626001729	Walker A/P-loop; other site
402626001730	ATP binding site [chemical binding]; other site
402626001731	Q-loop/lid; other site
402626001732	ABC transporter signature motif; other site
402626001733	Walker B; other site
402626001734	D-loop; other site
402626001735	H-loop/switch region; other site
402626001736	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
402626001737	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
402626001738	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626001739	Soluble P-type ATPase [General function prediction only]; Region: COG4087
402626001740	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
402626001741	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
402626001742	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
402626001743	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626001744	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
402626001745	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626001746	thymidine phosphorylase; Provisional; Region: PRK04350
402626001747	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
402626001748	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
402626001749	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
402626001750	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
402626001751	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
402626001752	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
402626001753	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
402626001754	active site
402626001755	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
402626001756	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
402626001757	Beta-Casp domain; Region: Beta-Casp; smart01027
402626001758	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
402626001759	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
402626001760	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
402626001761	putative dimer interface [polypeptide binding]; other site
402626001762	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
402626001763	FtsH Extracellular; Region: FtsH_ext; pfam06480
402626001764	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
402626001765	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626001766	Walker A motif; other site
402626001767	ATP binding site [chemical binding]; other site
402626001768	Walker B motif; other site
402626001769	arginine finger; other site
402626001770	Peptidase family M41; Region: Peptidase_M41; pfam01434
402626001771	Erythromycin esterase; Region: Erythro_esteras; pfam05139
402626001772	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
402626001773	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
402626001774	putative substrate binding site [chemical binding]; other site
402626001775	putative ATP binding site [chemical binding]; other site
402626001776	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889
402626001777	phosphoenolpyruvate synthase; Validated; Region: PRK06464
402626001778	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
402626001779	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
402626001780	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
402626001781	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
402626001782	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626001783	catalytic loop [active]
402626001784	iron binding site [ion binding]; other site
402626001785	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
402626001786	[4Fe-4S] binding site [ion binding]; other site
402626001787	molybdopterin cofactor binding site; other site
402626001788	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
402626001789	molybdopterin cofactor binding site; other site
402626001790	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
402626001791	SLBB domain; Region: SLBB; pfam10531
402626001792	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
402626001793	Histidine kinase; Region: HisKA_3; pfam07730
402626001794	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
402626001795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626001796	ATP binding site [chemical binding]; other site
402626001797	Mg2+ binding site [ion binding]; other site
402626001798	G-X-G motif; other site
402626001799	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
402626001800	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
402626001801	putative dimer interface [polypeptide binding]; other site
402626001802	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
402626001803	30S subunit binding site; other site
402626001804	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
402626001805	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
402626001806	ring oligomerisation interface [polypeptide binding]; other site
402626001807	ATP/Mg binding site [chemical binding]; other site
402626001808	stacking interactions; other site
402626001809	hinge regions; other site
402626001810	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
402626001811	ribonucleotide reductase-like protein; Provisional; Region: PRK06948
402626001812	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
402626001813	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
402626001814	active site
402626001815	dimer interface [polypeptide binding]; other site
402626001816	effector binding site; other site
402626001817	Beta-lactamase; Region: Beta-lactamase; pfam00144
402626001818	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
402626001819	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
402626001820	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
402626001821	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
402626001822	putative active site [active]
402626001823	putative metal binding site [ion binding]; other site
402626001824	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
402626001825	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
402626001826	hypothetical protein; Provisional; Region: PRK08609
402626001827	active site
402626001828	primer binding site [nucleotide binding]; other site
402626001829	NTP  binding site [chemical binding]; other site
402626001830	metal binding triad [ion binding]; metal-binding site
402626001831	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
402626001832	active site
402626001833	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
402626001834	30S subunit binding site; other site
402626001835	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
402626001836	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
402626001837	NAD(P) binding site [chemical binding]; other site
402626001838	homotetramer interface [polypeptide binding]; other site
402626001839	homodimer interface [polypeptide binding]; other site
402626001840	active site
402626001841	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
402626001842	putative FMN binding site [chemical binding]; other site
402626001843	NADPH bind site [chemical binding]; other site
402626001844	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
402626001845	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
402626001846	catalytic Zn binding site [ion binding]; other site
402626001847	structural Zn binding site [ion binding]; other site
402626001848	NAD(P) binding site [chemical binding]; other site
402626001849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
402626001850	AAA domain; Region: AAA_33; pfam13671
402626001851	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
402626001852	active site
402626001853	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
402626001854	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
402626001855	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
402626001856	active site
402626001857	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
402626001858	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
402626001859	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626001860	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
402626001861	Soluble P-type ATPase [General function prediction only]; Region: COG4087
402626001862	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
402626001863	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
402626001864	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
402626001865	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
402626001866	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
402626001867	Walker A/P-loop; other site
402626001868	ATP binding site [chemical binding]; other site
402626001869	Q-loop/lid; other site
402626001870	ABC transporter signature motif; other site
402626001871	Walker B; other site
402626001872	D-loop; other site
402626001873	H-loop/switch region; other site
402626001874	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
402626001875	FtsX-like permease family; Region: FtsX; pfam02687
402626001876	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626001877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626001878	active site
402626001879	phosphorylation site [posttranslational modification]
402626001880	intermolecular recognition site; other site
402626001881	dimerization interface [polypeptide binding]; other site
402626001882	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626001883	DNA binding residues [nucleotide binding]
402626001884	dimerization interface [polypeptide binding]; other site
402626001885	PAS domain S-box; Region: sensory_box; TIGR00229
402626001886	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626001887	putative active site [active]
402626001888	heme pocket [chemical binding]; other site
402626001889	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
402626001890	Histidine kinase; Region: HisKA_3; pfam07730
402626001891	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626001892	ATP binding site [chemical binding]; other site
402626001893	Mg2+ binding site [ion binding]; other site
402626001894	G-X-G motif; other site
402626001895	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
402626001896	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
402626001897	ligand binding site [chemical binding]; other site
402626001898	flexible hinge region; other site
402626001899	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
402626001900	putative switch regulator; other site
402626001901	non-specific DNA interactions [nucleotide binding]; other site
402626001902	DNA binding site [nucleotide binding]
402626001903	sequence specific DNA binding site [nucleotide binding]; other site
402626001904	putative cAMP binding site [chemical binding]; other site
402626001905	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
402626001906	BON domain; Region: BON; pfam04972
402626001907	BON domain; Region: BON; pfam04972
402626001908	BON domain; Region: BON; pfam04972
402626001909	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
402626001910	Flavodoxins [Energy production and conversion]; Region: FldA; COG0716
402626001911	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
402626001912	BON domain; Region: BON; pfam04972
402626001913	BON domain; Region: BON; pfam04972
402626001914	BON domain; Region: BON; pfam04972
402626001915	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
402626001916	Ligand Binding Site [chemical binding]; other site
402626001917	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
402626001918	Ligand Binding Site [chemical binding]; other site
402626001919	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
402626001920	Ligand Binding Site [chemical binding]; other site
402626001921	FOG: CBS domain [General function prediction only]; Region: COG0517
402626001922	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
402626001923	Predicted membrane protein [Function unknown]; Region: COG3174
402626001924	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
402626001925	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
402626001926	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
402626001927	putative NAD(P) binding site [chemical binding]; other site
402626001928	putative substrate binding site [chemical binding]; other site
402626001929	catalytic Zn binding site [ion binding]; other site
402626001930	structural Zn binding site [ion binding]; other site
402626001931	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
402626001932	Ligand Binding Site [chemical binding]; other site
402626001933	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
402626001934	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
402626001935	putative active site [active]
402626001936	putative dimer interface [polypeptide binding]; other site
402626001937	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
402626001938	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
402626001939	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
402626001940	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
402626001941	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626001942	Walker A/P-loop; other site
402626001943	ATP binding site [chemical binding]; other site
402626001944	Q-loop/lid; other site
402626001945	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
402626001946	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
402626001947	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626001948	Walker A/P-loop; other site
402626001949	ATP binding site [chemical binding]; other site
402626001950	Q-loop/lid; other site
402626001951	ABC transporter signature motif; other site
402626001952	Walker B; other site
402626001953	D-loop; other site
402626001954	H-loop/switch region; other site
402626001955	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
402626001956	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
402626001957	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
402626001958	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
402626001959	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
402626001960	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
402626001961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626001962	D-galactonate transporter; Region: 2A0114; TIGR00893
402626001963	putative substrate translocation pore; other site
402626001964	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
402626001965	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
402626001966	extended (e) SDRs; Region: SDR_e; cd08946
402626001967	NAD(P) binding site [chemical binding]; other site
402626001968	active site
402626001969	substrate binding site [chemical binding]; other site
402626001970	galactarate dehydratase; Region: galactar-dH20; TIGR03248
402626001971	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
402626001972	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
402626001973	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
402626001974	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
402626001975	active site
402626001976	tetramer interface [polypeptide binding]; other site
402626001977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626001978	D-galactonate transporter; Region: 2A0114; TIGR00893
402626001979	putative substrate translocation pore; other site
402626001980	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626001981	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
402626001982	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
402626001983	dimer interface [polypeptide binding]; other site
402626001984	NADP binding site [chemical binding]; other site
402626001985	catalytic residues [active]
402626001986	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
402626001987	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
402626001988	putative active site [active]
402626001989	catalytic residue [active]
402626001990	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
402626001991	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626001992	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
402626001993	putative dimerization interface [polypeptide binding]; other site
402626001994	putative substrate binding pocket [chemical binding]; other site
402626001995	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
402626001996	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626001997	membrane-bound complex binding site; other site
402626001998	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
402626001999	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
402626002000	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
402626002001	Walker A/P-loop; other site
402626002002	ATP binding site [chemical binding]; other site
402626002003	Q-loop/lid; other site
402626002004	ABC transporter signature motif; other site
402626002005	Walker B; other site
402626002006	D-loop; other site
402626002007	H-loop/switch region; other site
402626002008	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
402626002009	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626002010	dimer interface [polypeptide binding]; other site
402626002011	conserved gate region; other site
402626002012	putative PBP binding loops; other site
402626002013	ABC-ATPase subunit interface; other site
402626002014	NMT1-like family; Region: NMT1_2; pfam13379
402626002015	NMT1/THI5 like; Region: NMT1; pfam09084
402626002016	hypothetical protein; Provisional; Region: PRK06208
402626002017	intersubunit interface [polypeptide binding]; other site
402626002018	active site
402626002019	Zn2+ binding site [ion binding]; other site
402626002020	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
402626002021	active site
402626002022	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
402626002023	dimer interface [polypeptide binding]; other site
402626002024	non-prolyl cis peptide bond; other site
402626002025	insertion regions; other site
402626002026	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626002027	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
402626002028	active site
402626002029	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
402626002030	Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532
402626002031	active site residue [active]
402626002032	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
402626002033	active site residue [active]
402626002034	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
402626002035	active site residue [active]
402626002036	Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535
402626002037	active site residue [active]
402626002038	EamA-like transporter family; Region: EamA; pfam00892
402626002039	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
402626002040	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626002041	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626002042	metal binding site [ion binding]; metal-binding site
402626002043	active site
402626002044	I-site; other site
402626002045	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626002046	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
402626002047	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
402626002048	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
402626002049	N-terminal plug; other site
402626002050	ligand-binding site [chemical binding]; other site
402626002051	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
402626002052	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
402626002053	gamma subunit interface [polypeptide binding]; other site
402626002054	epsilon subunit interface [polypeptide binding]; other site
402626002055	LBP interface [polypeptide binding]; other site
402626002056	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626002057	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
402626002058	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
402626002059	dimerization interface [polypeptide binding]; other site
402626002060	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
402626002061	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
402626002062	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
402626002063	putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261
402626002064	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
402626002065	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
402626002066	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626002067	motif II; other site
402626002068	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
402626002069	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626002070	dimer interface [polypeptide binding]; other site
402626002071	conserved gate region; other site
402626002072	putative PBP binding loops; other site
402626002073	ABC-ATPase subunit interface; other site
402626002074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626002075	dimer interface [polypeptide binding]; other site
402626002076	conserved gate region; other site
402626002077	putative PBP binding loops; other site
402626002078	ABC-ATPase subunit interface; other site
402626002079	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
402626002080	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626002081	Walker A/P-loop; other site
402626002082	ATP binding site [chemical binding]; other site
402626002083	Q-loop/lid; other site
402626002084	ABC transporter signature motif; other site
402626002085	Walker B; other site
402626002086	D-loop; other site
402626002087	H-loop/switch region; other site
402626002088	TOBE domain; Region: TOBE_2; pfam08402
402626002089	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
402626002090	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626002091	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
402626002092	dimerization interface [polypeptide binding]; other site
402626002093	Peptidase M30; Region: Peptidase_M30; pfam10460
402626002094	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
402626002095	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
402626002096	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
402626002097	substrate binding site [chemical binding]; other site
402626002098	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
402626002099	substrate binding site [chemical binding]; other site
402626002100	ligand binding site [chemical binding]; other site
402626002101	Ferredoxin [Energy production and conversion]; Region: COG1146
402626002102	4Fe-4S binding domain; Region: Fer4; pfam00037
402626002103	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
402626002104	enoyl-CoA hydratase; Provisional; Region: PRK07509
402626002105	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626002106	substrate binding site [chemical binding]; other site
402626002107	oxyanion hole (OAH) forming residues; other site
402626002108	trimer interface [polypeptide binding]; other site
402626002109	Predicted membrane protein [Function unknown]; Region: COG4539
402626002110	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
402626002111	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
402626002112	ligand binding site [chemical binding]; other site
402626002113	flexible hinge region; other site
402626002114	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
402626002115	putative switch regulator; other site
402626002116	non-specific DNA interactions [nucleotide binding]; other site
402626002117	DNA binding site [nucleotide binding]
402626002118	sequence specific DNA binding site [nucleotide binding]; other site
402626002119	putative cAMP binding site [chemical binding]; other site
402626002120	elongation factor G; Reviewed; Region: PRK00007
402626002121	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
402626002122	G1 box; other site
402626002123	putative GEF interaction site [polypeptide binding]; other site
402626002124	GTP/Mg2+ binding site [chemical binding]; other site
402626002125	Switch I region; other site
402626002126	G2 box; other site
402626002127	G3 box; other site
402626002128	Switch II region; other site
402626002129	G4 box; other site
402626002130	G5 box; other site
402626002131	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
402626002132	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
402626002133	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
402626002134	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
402626002135	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
402626002136	transmembrane helices; other site
402626002137	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
402626002138	non-specific DNA binding site [nucleotide binding]; other site
402626002139	salt bridge; other site
402626002140	sequence-specific DNA binding site [nucleotide binding]; other site
402626002141	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
402626002142	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
402626002143	putative active site [active]
402626002144	putative PHP Thumb interface [polypeptide binding]; other site
402626002145	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
402626002146	generic binding surface II; other site
402626002147	generic binding surface I; other site
402626002148	DNA Polymerase Y-family; Region: PolY_like; cd03468
402626002149	active site
402626002150	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
402626002151	DNA binding site [nucleotide binding]
402626002152	Uncharacterized conserved protein [Function unknown]; Region: COG4544
402626002153	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
402626002154	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
402626002155	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
402626002156	Uncharacterized conserved protein [Function unknown]; Region: COG3542
402626002157	tartronate semialdehyde reductase; Provisional; Region: PRK15059
402626002158	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
402626002159	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
402626002160	benzoate transport; Region: 2A0115; TIGR00895
402626002161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626002162	putative substrate translocation pore; other site
402626002163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626002164	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626002165	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626002166	trimer interface [polypeptide binding]; other site
402626002167	eyelet of channel; other site
402626002168	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
402626002169	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
402626002170	FMN-binding pocket [chemical binding]; other site
402626002171	flavin binding motif; other site
402626002172	phosphate binding motif [ion binding]; other site
402626002173	beta-alpha-beta structure motif; other site
402626002174	NAD binding pocket [chemical binding]; other site
402626002175	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626002176	catalytic loop [active]
402626002177	iron binding site [ion binding]; other site
402626002178	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
402626002179	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626002180	putative active site [active]
402626002181	putative metal binding site [ion binding]; other site
402626002182	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
402626002183	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
402626002184	NAD(P) binding site [chemical binding]; other site
402626002185	catalytic residues [active]
402626002186	L-aspartate dehydrogenase; Provisional; Region: PRK13303
402626002187	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
402626002188	Domain of unknown function DUF108; Region: DUF108; pfam01958
402626002189	hypothetical protein; Provisional; Region: PRK07064
402626002190	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
402626002191	PYR/PP interface [polypeptide binding]; other site
402626002192	dimer interface [polypeptide binding]; other site
402626002193	TPP binding site [chemical binding]; other site
402626002194	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
402626002195	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
402626002196	TPP-binding site [chemical binding]; other site
402626002197	short chain dehydrogenase; Provisional; Region: PRK07062
402626002198	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
402626002199	putative NAD(P) binding site [chemical binding]; other site
402626002200	putative active site [active]
402626002201	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
402626002202	Transcriptional regulator [Transcription]; Region: IclR; COG1414
402626002203	Bacterial transcriptional regulator; Region: IclR; pfam01614
402626002204	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
402626002205	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
402626002206	Cupin domain; Region: Cupin_2; pfam07883
402626002207	short chain dehydrogenase; Provisional; Region: PRK12939
402626002208	classical (c) SDRs; Region: SDR_c; cd05233
402626002209	NAD(P) binding site [chemical binding]; other site
402626002210	active site
402626002211	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
402626002212	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
402626002213	[2Fe-2S] cluster binding site [ion binding]; other site
402626002214	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
402626002215	hydrophobic ligand binding site; other site
402626002216	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626002217	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626002218	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
402626002219	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626002220	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626002221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
402626002222	SnoaL-like domain; Region: SnoaL_2; pfam12680
402626002223	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
402626002224	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626002225	Coenzyme A binding pocket [chemical binding]; other site
402626002226	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
402626002227	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626002228	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626002229	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626002230	putative effector binding pocket; other site
402626002231	dimerization interface [polypeptide binding]; other site
402626002232	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
402626002233	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
402626002234	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
402626002235	homodimer interface [polypeptide binding]; other site
402626002236	substrate-cofactor binding pocket; other site
402626002237	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626002238	catalytic residue [active]
402626002239	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
402626002240	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
402626002241	Walker A/P-loop; other site
402626002242	ATP binding site [chemical binding]; other site
402626002243	Q-loop/lid; other site
402626002244	ABC transporter signature motif; other site
402626002245	Walker B; other site
402626002246	D-loop; other site
402626002247	H-loop/switch region; other site
402626002248	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
402626002249	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
402626002250	TM-ABC transporter signature motif; other site
402626002251	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
402626002252	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
402626002253	Walker A/P-loop; other site
402626002254	ATP binding site [chemical binding]; other site
402626002255	Q-loop/lid; other site
402626002256	ABC transporter signature motif; other site
402626002257	Walker B; other site
402626002258	D-loop; other site
402626002259	H-loop/switch region; other site
402626002260	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
402626002261	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
402626002262	TM-ABC transporter signature motif; other site
402626002263	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
402626002264	Transcriptional regulator [Transcription]; Region: IclR; COG1414
402626002265	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
402626002266	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
402626002267	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
402626002268	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
402626002269	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
402626002270	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
402626002271	active site
402626002272	catalytic tetrad [active]
402626002273	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626002274	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626002275	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
402626002276	substrate binding pocket [chemical binding]; other site
402626002277	dimerization interface [polypeptide binding]; other site
402626002278	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
402626002279	fumarylacetoacetase; Region: PLN02856
402626002280	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
402626002281	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
402626002282	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
402626002283	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
402626002284	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
402626002285	Walker A/P-loop; other site
402626002286	ATP binding site [chemical binding]; other site
402626002287	Q-loop/lid; other site
402626002288	ABC transporter signature motif; other site
402626002289	Walker B; other site
402626002290	D-loop; other site
402626002291	H-loop/switch region; other site
402626002292	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
402626002293	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
402626002294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626002295	dimer interface [polypeptide binding]; other site
402626002296	conserved gate region; other site
402626002297	putative PBP binding loops; other site
402626002298	ABC-ATPase subunit interface; other site
402626002299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626002300	dimer interface [polypeptide binding]; other site
402626002301	conserved gate region; other site
402626002302	putative PBP binding loops; other site
402626002303	ABC-ATPase subunit interface; other site
402626002304	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626002305	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626002306	active site
402626002307	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626002308	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626002309	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626002310	putative effector binding pocket; other site
402626002311	dimerization interface [polypeptide binding]; other site
402626002312	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
402626002313	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626002314	putative DNA binding site [nucleotide binding]; other site
402626002315	putative Zn2+ binding site [ion binding]; other site
402626002316	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
402626002317	putative dimerization interface [polypeptide binding]; other site
402626002318	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
402626002319	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
402626002320	THF binding site; other site
402626002321	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
402626002322	substrate binding site [chemical binding]; other site
402626002323	THF binding site; other site
402626002324	zinc-binding site [ion binding]; other site
402626002325	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
402626002326	Protein export membrane protein; Region: SecD_SecF; cl14618
402626002327	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626002328	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626002329	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
402626002330	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
402626002331	Rossmann-like domain; Region: Rossmann-like; pfam10727
402626002332	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
402626002333	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
402626002334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626002335	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
402626002336	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
402626002337	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
402626002338	oligomer interface [polypeptide binding]; other site
402626002339	metal binding site [ion binding]; metal-binding site
402626002340	metal binding site [ion binding]; metal-binding site
402626002341	putative Cl binding site [ion binding]; other site
402626002342	basic sphincter; other site
402626002343	hydrophobic gate; other site
402626002344	periplasmic entrance; other site
402626002345	Transcriptional regulators [Transcription]; Region: MarR; COG1846
402626002346	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626002347	putative DNA binding site [nucleotide binding]; other site
402626002348	putative Zn2+ binding site [ion binding]; other site
402626002349	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
402626002350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626002351	putative substrate translocation pore; other site
402626002352	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
402626002353	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
402626002354	substrate binding site [chemical binding]; other site
402626002355	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
402626002356	substrate binding site [chemical binding]; other site
402626002357	ligand binding site [chemical binding]; other site
402626002358	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
402626002359	aromatic amino acid exporter; Provisional; Region: PRK11689
402626002360	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
402626002361	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626002362	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626002363	dimerization interface [polypeptide binding]; other site
402626002364	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
402626002365	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
402626002366	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
402626002367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
402626002368	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
402626002369	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626002370	S-adenosylmethionine binding site [chemical binding]; other site
402626002371	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626002372	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626002373	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
402626002374	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
402626002375	FAD binding pocket [chemical binding]; other site
402626002376	FAD binding motif [chemical binding]; other site
402626002377	phosphate binding motif [ion binding]; other site
402626002378	beta-alpha-beta structure motif; other site
402626002379	NAD(p) ribose binding residues [chemical binding]; other site
402626002380	NAD binding pocket [chemical binding]; other site
402626002381	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
402626002382	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626002383	catalytic loop [active]
402626002384	iron binding site [ion binding]; other site
402626002385	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
402626002386	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
402626002387	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
402626002388	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
402626002389	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
402626002390	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
402626002391	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
402626002392	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626002393	putative substrate translocation pore; other site
402626002394	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
402626002395	dimer interface [polypeptide binding]; other site
402626002396	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626002397	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
402626002398	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626002399	WHG domain; Region: WHG; pfam13305
402626002400	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
402626002401	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
402626002402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626002403	active site
402626002404	phosphorylation site [posttranslational modification]
402626002405	intermolecular recognition site; other site
402626002406	dimerization interface [polypeptide binding]; other site
402626002407	TniQ; Region: TniQ; pfam06527
402626002408	Predicted transcriptional regulator [Transcription]; Region: COG2944
402626002409	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
402626002410	salt bridge; other site
402626002411	non-specific DNA binding site [nucleotide binding]; other site
402626002412	sequence-specific DNA binding site [nucleotide binding]; other site
402626002413	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
402626002414	AAA domain; Region: AAA_22; pfam13401
402626002415	Walker A motif; other site
402626002416	ATP binding site [chemical binding]; other site
402626002417	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
402626002418	Integrase core domain; Region: rve; pfam00665
402626002419	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
402626002420	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
402626002421	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
402626002422	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
402626002423	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
402626002424	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
402626002425	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626002426	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626002427	putative substrate translocation pore; other site
402626002428	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
402626002429	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
402626002430	NAD-dependent deacetylase; Provisional; Region: PRK00481
402626002431	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
402626002432	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
402626002433	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
402626002434	DNA binding residues [nucleotide binding]
402626002435	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
402626002436	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
402626002437	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
402626002438	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
402626002439	catalytic residues [active]
402626002440	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626002441	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626002442	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626002443	putative effector binding pocket; other site
402626002444	dimerization interface [polypeptide binding]; other site
402626002445	DinB superfamily; Region: DinB_2; pfam12867
402626002446	CopC domain; Region: CopC; pfam04234
402626002447	YHS domain; Region: YHS; pfam04945
402626002448	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
402626002449	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626002450	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626002451	motif II; other site
402626002452	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
402626002453	Disulfide bond isomerase protein N-terminus; Region: DsbC_N; pfam10411
402626002454	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
402626002455	dimerization domain [polypeptide binding]; other site
402626002456	dimer interface [polypeptide binding]; other site
402626002457	catalytic residues [active]
402626002458	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626002459	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626002460	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626002461	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
402626002462	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626002463	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626002464	metal binding site [ion binding]; metal-binding site
402626002465	active site
402626002466	I-site; other site
402626002467	Phosphoesterase family; Region: Phosphoesterase; pfam04185
402626002468	Phosphoesterase family; Region: Phosphoesterase; pfam04185
402626002469	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
402626002470	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
402626002471	Chromate transporter; Region: Chromate_transp; pfam02417
402626002472	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
402626002473	active site 1 [active]
402626002474	dimer interface [polypeptide binding]; other site
402626002475	hexamer interface [polypeptide binding]; other site
402626002476	active site 2 [active]
402626002477	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
402626002478	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
402626002479	active site
402626002480	catalytic residues [active]
402626002481	metal binding site [ion binding]; metal-binding site
402626002482	DmpG-like communication domain; Region: DmpG_comm; pfam07836
402626002483	acetaldehyde dehydrogenase; Validated; Region: PRK08300
402626002484	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
402626002485	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
402626002486	4-oxalocrotonate decarboxylase; Region: catechol_dmpH; TIGR03218
402626002487	2-oxopent-4-enoate hydratase; Region: catechol_dmpE; TIGR03220
402626002488	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
402626002489	2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216
402626002490	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
402626002491	NAD binding site [chemical binding]; other site
402626002492	catalytic residues [active]
402626002493	Domain of unknown function (DUF336); Region: DUF336; pfam03928
402626002494	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
402626002495	N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265
402626002496	tetramer interface [polypeptide binding]; other site
402626002497	C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243
402626002498	tetramer interface [polypeptide binding]; other site
402626002499	active site
402626002500	Fe binding site [ion binding]; other site
402626002501	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
402626002502	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626002503	catalytic loop [active]
402626002504	iron binding site [ion binding]; other site
402626002505	Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211
402626002506	FAD binding pocket [chemical binding]; other site
402626002507	FAD binding motif [chemical binding]; other site
402626002508	phosphate binding motif [ion binding]; other site
402626002509	beta-alpha-beta structure motif; other site
402626002510	NAD binding pocket [chemical binding]; other site
402626002511	Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663
402626002512	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
402626002513	dimerization interface [polypeptide binding]; other site
402626002514	putative path to active site cavity [active]
402626002515	diiron center [ion binding]; other site
402626002516	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
402626002517	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
402626002518	dimerization interface [polypeptide binding]; other site
402626002519	Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099
402626002520	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
402626002521	dinuclear metal binding motif [ion binding]; other site
402626002522	Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234
402626002523	Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474
402626002524	[2Fe-2S] cluster binding site [ion binding]; other site
402626002525	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
402626002526	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
402626002527	dimerization interface [polypeptide binding]; other site
402626002528	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
402626002529	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626002530	catalytic loop [active]
402626002531	iron binding site [ion binding]; other site
402626002532	Toluene-4-monoxygenase electron transfer component of Pseudomonas mendocina hydroxylates toluene and forms p-cresol as part of a three component toluene-4-monoxygenase system. Electron transfer is from NADH to an NADH:ferredoxin oxidoreductase (TmoF in P; Region: T4MO_e_transfer_like; cd06190
402626002533	FAD binding pocket [chemical binding]; other site
402626002534	FAD binding motif [chemical binding]; other site
402626002535	phosphate binding motif [ion binding]; other site
402626002536	beta-alpha-beta structure motif; other site
402626002537	NAD binding pocket [chemical binding]; other site
402626002538	Activator of aromatic catabolism; Region: XylR_N; pfam06505
402626002539	V4R domain; Region: V4R; pfam02830
402626002540	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
402626002541	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626002542	Walker A motif; other site
402626002543	ATP binding site [chemical binding]; other site
402626002544	Walker B motif; other site
402626002545	arginine finger; other site
402626002546	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626002547	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
402626002548	Activator of aromatic catabolism; Region: XylR_N; pfam06505
402626002549	V4R domain; Region: V4R; pfam02830
402626002550	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
402626002551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626002552	Walker A motif; other site
402626002553	ATP binding site [chemical binding]; other site
402626002554	Walker B motif; other site
402626002555	arginine finger; other site
402626002556	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626002557	Transcriptional regulators [Transcription]; Region: FadR; COG2186
402626002558	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626002559	DNA-binding site [nucleotide binding]; DNA binding site
402626002560	FCD domain; Region: FCD; pfam07729
402626002561	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
402626002562	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626002563	catalytic loop [active]
402626002564	iron binding site [ion binding]; other site
402626002565	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
402626002566	[4Fe-4S] binding site [ion binding]; other site
402626002567	molybdopterin cofactor binding site; other site
402626002568	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
402626002569	molybdopterin cofactor binding site; other site
402626002570	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
402626002571	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
402626002572	acetyl-CoA synthetase; Provisional; Region: PRK04319
402626002573	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
402626002574	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
402626002575	active site
402626002576	acyl-activating enzyme (AAE) consensus motif; other site
402626002577	putative CoA binding site [chemical binding]; other site
402626002578	AMP binding site [chemical binding]; other site
402626002579	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
402626002580	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
402626002581	tetramer interface [polypeptide binding]; other site
402626002582	TPP-binding site [chemical binding]; other site
402626002583	heterodimer interface [polypeptide binding]; other site
402626002584	phosphorylation loop region [posttranslational modification]
402626002585	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
402626002586	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
402626002587	alpha subunit interface [polypeptide binding]; other site
402626002588	TPP binding site [chemical binding]; other site
402626002589	heterodimer interface [polypeptide binding]; other site
402626002590	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
402626002591	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
402626002592	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
402626002593	E3 interaction surface; other site
402626002594	lipoyl attachment site [posttranslational modification]; other site
402626002595	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
402626002596	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
402626002597	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
402626002598	30S subunit binding site; other site
402626002599	PAS domain S-box; Region: sensory_box; TIGR00229
402626002600	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626002601	putative active site [active]
402626002602	heme pocket [chemical binding]; other site
402626002603	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
402626002604	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626002605	ATP binding site [chemical binding]; other site
402626002606	Mg2+ binding site [ion binding]; other site
402626002607	G-X-G motif; other site
402626002608	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
402626002609	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
402626002610	ring oligomerisation interface [polypeptide binding]; other site
402626002611	ATP/Mg binding site [chemical binding]; other site
402626002612	stacking interactions; other site
402626002613	hinge regions; other site
402626002614	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
402626002615	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
402626002616	active site
402626002617	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
402626002618	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
402626002619	Hemerythrin-like domain; Region: Hr-like; cd12108
402626002620	Fe binding site [ion binding]; other site
402626002621	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
402626002622	GAF domain; Region: GAF; cl17456
402626002623	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626002624	Walker A motif; other site
402626002625	ATP binding site [chemical binding]; other site
402626002626	Walker B motif; other site
402626002627	arginine finger; other site
402626002628	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
402626002629	ATP cone domain; Region: ATP-cone; pfam03477
402626002630	Class III ribonucleotide reductase; Region: RNR_III; cd01675
402626002631	effector binding site; other site
402626002632	active site
402626002633	Zn binding site [ion binding]; other site
402626002634	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
402626002635	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
402626002636	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626002637	FeS/SAM binding site; other site
402626002638	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
402626002639	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
402626002640	ligand binding site [chemical binding]; other site
402626002641	flexible hinge region; other site
402626002642	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
402626002643	putative switch regulator; other site
402626002644	non-specific DNA interactions [nucleotide binding]; other site
402626002645	DNA binding site [nucleotide binding]
402626002646	sequence specific DNA binding site [nucleotide binding]; other site
402626002647	putative cAMP binding site [chemical binding]; other site
402626002648	Uncharacterized conserved protein [Function unknown]; Region: COG4273
402626002649	SCP-2 sterol transfer family; Region: SCP2; cl01225
402626002650	putative protease; Provisional; Region: PRK15447
402626002651	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
402626002652	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
402626002653	Peptidase family U32; Region: Peptidase_U32; pfam01136
402626002654	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
402626002655	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626002656	putative substrate translocation pore; other site
402626002657	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
402626002658	Uncharacterized conserved protein [Function unknown]; Region: COG1284
402626002659	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
402626002660	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
402626002661	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
402626002662	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
402626002663	[4Fe-4S] binding site [ion binding]; other site
402626002664	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
402626002665	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
402626002666	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
402626002667	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
402626002668	molybdopterin cofactor binding site; other site
402626002669	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
402626002670	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
402626002671	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
402626002672	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
402626002673	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
402626002674	Walker A motif; other site
402626002675	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
402626002676	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
402626002677	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626002678	dimerization interface [polypeptide binding]; other site
402626002679	GAF domain; Region: GAF; pfam01590
402626002680	Histidine kinase; Region: HisKA_3; pfam07730
402626002681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626002682	ATP binding site [chemical binding]; other site
402626002683	Mg2+ binding site [ion binding]; other site
402626002684	G-X-G motif; other site
402626002685	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626002686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626002687	active site
402626002688	phosphorylation site [posttranslational modification]
402626002689	intermolecular recognition site; other site
402626002690	dimerization interface [polypeptide binding]; other site
402626002691	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626002692	DNA binding residues [nucleotide binding]
402626002693	dimerization interface [polypeptide binding]; other site
402626002694	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
402626002695	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626002696	S-adenosylmethionine binding site [chemical binding]; other site
402626002697	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
402626002698	Methyltransferase domain; Region: Methyltransf_32; pfam13679
402626002699	Methyltransferase domain; Region: Methyltransf_31; pfam13847
402626002700	PAS domain; Region: PAS_9; pfam13426
402626002701	PAS domain; Region: PAS_9; pfam13426
402626002702	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626002703	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626002704	metal binding site [ion binding]; metal-binding site
402626002705	active site
402626002706	I-site; other site
402626002707	Peptidase family M1; Region: Peptidase_M1; pfam01433
402626002708	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
402626002709	Zn binding site [ion binding]; other site
402626002710	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
402626002711	Nitrogen regulatory protein P-II; Region: P-II; smart00938
402626002712	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
402626002713	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
402626002714	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
402626002715	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626002716	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
402626002717	sensor protein QseC; Provisional; Region: PRK10337
402626002718	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626002719	dimer interface [polypeptide binding]; other site
402626002720	phosphorylation site [posttranslational modification]
402626002721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626002722	ATP binding site [chemical binding]; other site
402626002723	Mg2+ binding site [ion binding]; other site
402626002724	G-X-G motif; other site
402626002725	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
402626002726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626002727	active site
402626002728	phosphorylation site [posttranslational modification]
402626002729	intermolecular recognition site; other site
402626002730	dimerization interface [polypeptide binding]; other site
402626002731	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626002732	DNA binding site [nucleotide binding]
402626002733	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626002734	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626002735	metal binding site [ion binding]; metal-binding site
402626002736	active site
402626002737	I-site; other site
402626002738	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
402626002739	Mechanosensitive ion channel; Region: MS_channel; pfam00924
402626002740	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
402626002741	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
402626002742	NodB motif; other site
402626002743	putative active site [active]
402626002744	putative catalytic site [active]
402626002745	putative Zn binding site [ion binding]; other site
402626002746	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
402626002747	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
402626002748	active site
402626002749	homodimer interface [polypeptide binding]; other site
402626002750	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
402626002751	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
402626002752	active site
402626002753	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
402626002754	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
402626002755	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
402626002756	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
402626002757	dimer interface [polypeptide binding]; other site
402626002758	ligand binding site [chemical binding]; other site
402626002759	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626002760	dimerization interface [polypeptide binding]; other site
402626002761	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626002762	dimer interface [polypeptide binding]; other site
402626002763	putative CheW interface [polypeptide binding]; other site
402626002764	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
402626002765	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
402626002766	putative ligand binding site [chemical binding]; other site
402626002767	NAD binding site [chemical binding]; other site
402626002768	catalytic site [active]
402626002769	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
402626002770	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
402626002771	putative ligand binding site [chemical binding]; other site
402626002772	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626002773	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626002774	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
402626002775	HIT family signature motif; other site
402626002776	catalytic residue [active]
402626002777	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
402626002778	hypothetical protein; Provisional; Region: PRK08262
402626002779	M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674
402626002780	metal binding site [ion binding]; metal-binding site
402626002781	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
402626002782	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626002783	DNA-binding site [nucleotide binding]; DNA binding site
402626002784	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626002785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626002786	homodimer interface [polypeptide binding]; other site
402626002787	catalytic residue [active]
402626002788	Protein of unknown function (DUF3005); Region: DUF3005; pfam11448
402626002789	enoyl-CoA hydratase; Provisional; Region: PRK06688
402626002790	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626002791	substrate binding site [chemical binding]; other site
402626002792	oxyanion hole (OAH) forming residues; other site
402626002793	trimer interface [polypeptide binding]; other site
402626002794	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
402626002795	MarR family; Region: MarR_2; pfam12802
402626002796	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
402626002797	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
402626002798	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626002799	dimerization interface [polypeptide binding]; other site
402626002800	putative DNA binding site [nucleotide binding]; other site
402626002801	putative Zn2+ binding site [ion binding]; other site
402626002802	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
402626002803	putative hydrophobic ligand binding site [chemical binding]; other site
402626002804	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900
402626002805	putative hydrophobic ligand binding site [chemical binding]; other site
402626002806	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
402626002807	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
402626002808	dimer interface [polypeptide binding]; other site
402626002809	active site
402626002810	CoA binding pocket [chemical binding]; other site
402626002811	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
402626002812	catalytic core [active]
402626002813	short chain dehydrogenase; Provisional; Region: PRK07035
402626002814	classical (c) SDRs; Region: SDR_c; cd05233
402626002815	NAD(P) binding site [chemical binding]; other site
402626002816	active site
402626002817	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
402626002818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626002819	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626002820	putative substrate translocation pore; other site
402626002821	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
402626002822	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
402626002823	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
402626002824	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626002825	Coenzyme A binding pocket [chemical binding]; other site
402626002826	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
402626002827	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
402626002828	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
402626002829	active site residue [active]
402626002830	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
402626002831	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
402626002832	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
402626002833	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
402626002834	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
402626002835	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
402626002836	Walker A motif/ATP binding site; other site
402626002837	Walker B motif; other site
402626002838	flagellar assembly protein H; Validated; Region: fliH; PRK05687
402626002839	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
402626002840	Flagellar assembly protein FliH; Region: FliH; pfam02108
402626002841	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
402626002842	FliG C-terminal domain; Region: FliG_C; pfam01706
402626002843	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
402626002844	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
402626002845	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
402626002846	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
402626002847	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
402626002848	active site
402626002849	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
402626002850	binding surface
402626002851	TPR motif; other site
402626002852	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
402626002853	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
402626002854	substrate binding site; other site
402626002855	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
402626002856	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
402626002857	NAD binding site [chemical binding]; other site
402626002858	homotetramer interface [polypeptide binding]; other site
402626002859	homodimer interface [polypeptide binding]; other site
402626002860	substrate binding site [chemical binding]; other site
402626002861	active site
402626002862	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
402626002863	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
402626002864	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
402626002865	inhibitor-cofactor binding pocket; inhibition site
402626002866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626002867	catalytic residue [active]
402626002868	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
402626002869	Methyltransferase domain; Region: Methyltransf_23; pfam13489
402626002870	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626002871	S-adenosylmethionine binding site [chemical binding]; other site
402626002872	NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234
402626002873	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
402626002874	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
402626002875	WbqC-like protein family; Region: WbqC; pfam08889
402626002876	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
402626002877	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
402626002878	active site
402626002879	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
402626002880	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
402626002881	Transcriptional regulators [Transcription]; Region: MarR; COG1846
402626002882	MarR family; Region: MarR; pfam01047
402626002883	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
402626002884	active site
402626002885	TPR repeat; Region: TPR_11; pfam13414
402626002886	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
402626002887	binding surface
402626002888	TPR motif; other site
402626002889	Flagellar protein FliT; Region: FliT; pfam05400
402626002890	Flagellar protein FliS; Region: FliS; cl00654
402626002891	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
402626002892	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
402626002893	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
402626002894	flagellin; Provisional; Region: PRK12802
402626002895	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
402626002896	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
402626002897	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626002898	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626002899	active site
402626002900	phosphorylation site [posttranslational modification]
402626002901	intermolecular recognition site; other site
402626002902	dimerization interface [polypeptide binding]; other site
402626002903	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626002904	DNA binding residues [nucleotide binding]
402626002905	dimerization interface [polypeptide binding]; other site
402626002906	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626002907	PAS domain; Region: PAS_9; pfam13426
402626002908	putative active site [active]
402626002909	heme pocket [chemical binding]; other site
402626002910	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626002911	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626002912	metal binding site [ion binding]; metal-binding site
402626002913	active site
402626002914	I-site; other site
402626002915	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626002916	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
402626002917	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
402626002918	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
402626002919	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
402626002920	Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190
402626002921	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
402626002922	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
402626002923	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
402626002924	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
402626002925	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
402626002926	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
402626002927	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
402626002928	putative acyl-acceptor binding pocket; other site
402626002929	Phosphopantetheine attachment site; Region: PP-binding; cl09936
402626002930	acyl carrier protein; Provisional; Region: PRK05350
402626002931	Predicted membrane protein [Function unknown]; Region: COG4648
402626002932	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
402626002933	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
402626002934	AMP binding site [chemical binding]; other site
402626002935	active site
402626002936	acyl-activating enzyme (AAE) consensus motif; other site
402626002937	CoA binding site [chemical binding]; other site
402626002938	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
402626002939	active site 2 [active]
402626002940	dimer interface [polypeptide binding]; other site
402626002941	active site 1 [active]
402626002942	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
402626002943	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
402626002944	Ligand binding site; other site
402626002945	Putative Catalytic site; other site
402626002946	DXD motif; other site
402626002947	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
402626002948	putative acyl-acceptor binding pocket; other site
402626002949	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
402626002950	active sites [active]
402626002951	tetramer interface [polypeptide binding]; other site
402626002952	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
402626002953	active site
402626002954	Predicted exporter [General function prediction only]; Region: COG4258
402626002955	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
402626002956	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
402626002957	dimer interface [polypeptide binding]; other site
402626002958	active site
402626002959	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
402626002960	putative active site 1 [active]
402626002961	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
402626002962	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
402626002963	NAD(P) binding site [chemical binding]; other site
402626002964	homotetramer interface [polypeptide binding]; other site
402626002965	homodimer interface [polypeptide binding]; other site
402626002966	active site
402626002967	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
402626002968	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
402626002969	dimer interface [polypeptide binding]; other site
402626002970	active site
402626002971	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
402626002972	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
402626002973	dimer interface [polypeptide binding]; other site
402626002974	active site
402626002975	Methyltransferase domain; Region: Methyltransf_23; pfam13489
402626002976	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626002977	S-adenosylmethionine binding site [chemical binding]; other site
402626002978	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
402626002979	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
402626002980	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
402626002981	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
402626002982	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
402626002983	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
402626002984	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
402626002985	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
402626002986	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
402626002987	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
402626002988	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
402626002989	Flagellar L-ring protein; Region: FlgH; pfam02107
402626002990	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
402626002991	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
402626002992	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
402626002993	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
402626002994	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
402626002995	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
402626002996	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
402626002997	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
402626002998	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
402626002999	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
402626003000	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
402626003001	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
402626003002	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
402626003003	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
402626003004	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
402626003005	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
402626003006	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
402626003007	SAF-like; Region: SAF_2; pfam13144
402626003008	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
402626003009	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
402626003010	FlgN protein; Region: FlgN; pfam05130
402626003011	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626003012	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626003013	DNA binding residues [nucleotide binding]
402626003014	dimerization interface [polypeptide binding]; other site
402626003015	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626003016	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626003017	trimer interface [polypeptide binding]; other site
402626003018	eyelet of channel; other site
402626003019	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
402626003020	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626003021	DNA-binding site [nucleotide binding]; DNA binding site
402626003022	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
402626003023	H-NS histone family; Region: Histone_HNS; pfam00816
402626003024	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
402626003025	PAS fold; Region: PAS_4; pfam08448
402626003026	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626003027	putative active site [active]
402626003028	heme pocket [chemical binding]; other site
402626003029	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626003030	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626003031	metal binding site [ion binding]; metal-binding site
402626003032	active site
402626003033	I-site; other site
402626003034	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626003035	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
402626003036	tetramer interface [polypeptide binding]; other site
402626003037	active site
402626003038	Mg2+/Mn2+ binding site [ion binding]; other site
402626003039	isocitrate lyase; Region: PLN02892
402626003040	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
402626003041	Ligand binding site; other site
402626003042	metal-binding site
402626003043	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
402626003044	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
402626003045	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
402626003046	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
402626003047	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
402626003048	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626003049	catalytic loop [active]
402626003050	iron binding site [ion binding]; other site
402626003051	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
402626003052	2-isopropylmalate synthase; Validated; Region: PRK03739
402626003053	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
402626003054	active site
402626003055	catalytic residues [active]
402626003056	metal binding site [ion binding]; metal-binding site
402626003057	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
402626003058	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
402626003059	dimerization interface [polypeptide binding]; other site
402626003060	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
402626003061	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
402626003062	DNA binding residues [nucleotide binding]
402626003063	dimer interface [polypeptide binding]; other site
402626003064	putative metal binding site [ion binding]; other site
402626003065	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
402626003066	Heavy-metal-associated domain; Region: HMA; pfam00403
402626003067	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626003068	Soluble P-type ATPase [General function prediction only]; Region: COG4087
402626003069	Serine hydrolase; Region: Ser_hydrolase; pfam06821
402626003070	Citrate transporter; Region: CitMHS; pfam03600
402626003071	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
402626003072	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
402626003073	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626003074	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626003075	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
402626003076	putative dimerization interface [polypeptide binding]; other site
402626003077	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
402626003078	Ligand Binding Site [chemical binding]; other site
402626003079	SnoaL-like domain; Region: SnoaL_2; pfam12680
402626003080	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
402626003081	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
402626003082	FMN binding site [chemical binding]; other site
402626003083	substrate binding site [chemical binding]; other site
402626003084	putative catalytic residue [active]
402626003085	Predicted transcriptional regulators [Transcription]; Region: COG1695
402626003086	Transcriptional regulator PadR-like family; Region: PadR; cl17335
402626003087	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
402626003088	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
402626003089	Beta-lactamase; Region: Beta-lactamase; pfam00144
402626003090	LysR family transcriptional regulator; Provisional; Region: PRK14997
402626003091	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626003092	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626003093	putative effector binding pocket; other site
402626003094	dimerization interface [polypeptide binding]; other site
402626003095	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
402626003096	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
402626003097	FMN binding site [chemical binding]; other site
402626003098	substrate binding site [chemical binding]; other site
402626003099	putative catalytic residue [active]
402626003100	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
402626003101	CGNR zinc finger; Region: zf-CGNR; pfam11706
402626003102	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
402626003103	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626003104	NAD(P) binding site [chemical binding]; other site
402626003105	active site
402626003106	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626003107	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
402626003108	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
402626003109	conserved cys residue [active]
402626003110	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
402626003111	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
402626003112	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
402626003113	putative N-terminal domain interface [polypeptide binding]; other site
402626003114	putative dimer interface [polypeptide binding]; other site
402626003115	putative substrate binding pocket (H-site) [chemical binding]; other site
402626003116	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
402626003117	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
402626003118	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
402626003119	Response regulator receiver domain; Region: Response_reg; pfam00072
402626003120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626003121	active site
402626003122	phosphorylation site [posttranslational modification]
402626003123	intermolecular recognition site; other site
402626003124	dimerization interface [polypeptide binding]; other site
402626003125	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626003126	dimerization interface [polypeptide binding]; other site
402626003127	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
402626003128	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
402626003129	putative binding surface; other site
402626003130	active site
402626003131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626003132	ATP binding site [chemical binding]; other site
402626003133	Mg2+ binding site [ion binding]; other site
402626003134	G-X-G motif; other site
402626003135	Uncharacterized conserved protein [Function unknown]; Region: COG5649
402626003136	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
402626003137	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
402626003138	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
402626003139	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
402626003140	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
402626003141	PgaD-like protein; Region: PgaD; pfam13994
402626003142	N-glycosyltransferase; Provisional; Region: PRK11204
402626003143	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
402626003144	DXD motif; other site
402626003145	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
402626003146	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
402626003147	putative active site [active]
402626003148	putative metal binding site [ion binding]; other site
402626003149	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
402626003150	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626003151	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626003152	DNA binding residues [nucleotide binding]
402626003153	dimerization interface [polypeptide binding]; other site
402626003154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626003155	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
402626003156	NAD(P) binding site [chemical binding]; other site
402626003157	active site
402626003158	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
402626003159	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
402626003160	substrate-cofactor binding pocket; other site
402626003161	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626003162	catalytic residue [active]
402626003163	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
402626003164	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
402626003165	non-specific DNA binding site [nucleotide binding]; other site
402626003166	salt bridge; other site
402626003167	sequence-specific DNA binding site [nucleotide binding]; other site
402626003168	Cupin domain; Region: Cupin_2; cl17218
402626003169	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
402626003170	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
402626003171	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
402626003172	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626003173	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626003174	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
402626003175	putative effector binding pocket; other site
402626003176	putative dimerization interface [polypeptide binding]; other site
402626003177	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
402626003178	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
402626003179	active site
402626003180	catalytic tetrad [active]
402626003181	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
402626003182	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626003183	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
402626003184	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626003185	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626003186	metal binding site [ion binding]; metal-binding site
402626003187	active site
402626003188	I-site; other site
402626003189	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
402626003190	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
402626003191	PhoD-like phosphatase; Region: PhoD; pfam09423
402626003192	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
402626003193	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
402626003194	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
402626003195	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
402626003196	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
402626003197	ligand binding site [chemical binding]; other site
402626003198	flexible hinge region; other site
402626003199	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
402626003200	chorismate mutase; Provisional; Region: PRK09269
402626003201	Chorismate mutase type II; Region: CM_2; cl00693
402626003202	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
402626003203	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
402626003204	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
402626003205	protein binding site [polypeptide binding]; other site
402626003206	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
402626003207	protein binding site [polypeptide binding]; other site
402626003208	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626003209	dimer interface [polypeptide binding]; other site
402626003210	phosphorylation site [posttranslational modification]
402626003211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626003212	ATP binding site [chemical binding]; other site
402626003213	Mg2+ binding site [ion binding]; other site
402626003214	G-X-G motif; other site
402626003215	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
402626003216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626003217	active site
402626003218	phosphorylation site [posttranslational modification]
402626003219	intermolecular recognition site; other site
402626003220	dimerization interface [polypeptide binding]; other site
402626003221	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626003222	DNA binding site [nucleotide binding]
402626003223	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
402626003224	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
402626003225	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
402626003226	putative active site [active]
402626003227	glucokinase; Provisional; Region: glk; PRK00292
402626003228	glucokinase, proteobacterial type; Region: glk; TIGR00749
402626003229	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
402626003230	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
402626003231	putative active site [active]
402626003232	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
402626003233	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
402626003234	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
402626003235	phosphogluconate dehydratase; Validated; Region: PRK09054
402626003236	6-phosphogluconate dehydratase; Region: edd; TIGR01196
402626003237	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
402626003238	Ligand Binding Site [chemical binding]; other site
402626003239	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
402626003240	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
402626003241	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
402626003242	Cytochrome c; Region: Cytochrom_C; cl11414
402626003243	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
402626003244	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cd00919
402626003245	D-pathway; other site
402626003246	Low-spin heme binding site [chemical binding]; other site
402626003247	Putative water exit pathway; other site
402626003248	Binuclear center (active site) [active]
402626003249	K-pathway; other site
402626003250	Putative proton exit pathway; other site
402626003251	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865
402626003252	Subunit I/III interface [polypeptide binding]; other site
402626003253	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864
402626003254	Subunit I/III interface [polypeptide binding]; other site
402626003255	Predicted small integral membrane protein [Function unknown]; Region: COG5605
402626003256	hypothetical protein; Provisional; Region: PRK05939
402626003257	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
402626003258	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
402626003259	catalytic residue [active]
402626003260	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
402626003261	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
402626003262	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626003263	Walker A/P-loop; other site
402626003264	ATP binding site [chemical binding]; other site
402626003265	Q-loop/lid; other site
402626003266	ABC transporter signature motif; other site
402626003267	Walker B; other site
402626003268	D-loop; other site
402626003269	H-loop/switch region; other site
402626003270	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
402626003271	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
402626003272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626003273	active site
402626003274	phosphorylation site [posttranslational modification]
402626003275	intermolecular recognition site; other site
402626003276	dimerization interface [polypeptide binding]; other site
402626003277	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
402626003278	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
402626003279	putative ADP-binding pocket [chemical binding]; other site
402626003280	short chain dehydrogenase; Provisional; Region: PRK07326
402626003281	classical (c) SDRs; Region: SDR_c; cd05233
402626003282	NAD(P) binding site [chemical binding]; other site
402626003283	active site
402626003284	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
402626003285	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626003286	active site
402626003287	motif I; other site
402626003288	motif II; other site
402626003289	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
402626003290	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
402626003291	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
402626003292	putative active site [active]
402626003293	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
402626003294	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
402626003295	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
402626003296	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
402626003297	Probable Catalytic site; other site
402626003298	metal-binding site
402626003299	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
402626003300	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
402626003301	putative active site [active]
402626003302	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
402626003303	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
402626003304	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
402626003305	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
402626003306	NAD binding site [chemical binding]; other site
402626003307	putative substrate binding site 2 [chemical binding]; other site
402626003308	putative substrate binding site 1 [chemical binding]; other site
402626003309	active site
402626003310	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
402626003311	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
402626003312	Probable Catalytic site; other site
402626003313	metal-binding site
402626003314	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
402626003315	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
402626003316	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
402626003317	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
402626003318	Predicted membrane protein [Function unknown]; Region: COG2323
402626003319	short chain dehydrogenase; Provisional; Region: PRK06701
402626003320	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
402626003321	NAD binding site [chemical binding]; other site
402626003322	metal binding site [ion binding]; metal-binding site
402626003323	active site
402626003324	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
402626003325	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626003326	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
402626003327	E3 interaction surface; other site
402626003328	lipoyl attachment site [posttranslational modification]; other site
402626003329	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626003330	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
402626003331	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
402626003332	homotrimer interaction site [polypeptide binding]; other site
402626003333	putative active site [active]
402626003334	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
402626003335	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
402626003336	Uncharacterized conserved protein [Function unknown]; Region: COG5476
402626003337	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
402626003338	MlrC C-terminus; Region: MlrC_C; pfam07171
402626003339	allantoate amidohydrolase; Reviewed; Region: PRK12893
402626003340	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
402626003341	active site
402626003342	metal binding site [ion binding]; metal-binding site
402626003343	dimer interface [polypeptide binding]; other site
402626003344	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
402626003345	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
402626003346	Walker A/P-loop; other site
402626003347	ATP binding site [chemical binding]; other site
402626003348	Q-loop/lid; other site
402626003349	ABC transporter signature motif; other site
402626003350	Walker B; other site
402626003351	D-loop; other site
402626003352	H-loop/switch region; other site
402626003353	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
402626003354	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
402626003355	Walker A/P-loop; other site
402626003356	ATP binding site [chemical binding]; other site
402626003357	Q-loop/lid; other site
402626003358	ABC transporter signature motif; other site
402626003359	Walker B; other site
402626003360	D-loop; other site
402626003361	H-loop/switch region; other site
402626003362	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
402626003363	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626003364	TM-ABC transporter signature motif; other site
402626003365	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626003366	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
402626003367	TM-ABC transporter signature motif; other site
402626003368	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
402626003369	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
402626003370	putative ligand binding site [chemical binding]; other site
402626003371	Transcriptional regulators [Transcription]; Region: FadR; COG2186
402626003372	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626003373	DNA-binding site [nucleotide binding]; DNA binding site
402626003374	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
402626003375	cyanate hydratase; Validated; Region: PRK02866
402626003376	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
402626003377	oligomer interface [polypeptide binding]; other site
402626003378	active site
402626003379	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
402626003380	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
402626003381	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
402626003382	putative ligand binding site [chemical binding]; other site
402626003383	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
402626003384	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
402626003385	Walker A/P-loop; other site
402626003386	ATP binding site [chemical binding]; other site
402626003387	Q-loop/lid; other site
402626003388	ABC transporter signature motif; other site
402626003389	Walker B; other site
402626003390	D-loop; other site
402626003391	H-loop/switch region; other site
402626003392	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
402626003393	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
402626003394	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
402626003395	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626003396	TM-ABC transporter signature motif; other site
402626003397	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
402626003398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626003399	NAD(P) binding site [chemical binding]; other site
402626003400	active site
402626003401	Transcriptional regulators [Transcription]; Region: PurR; COG1609
402626003402	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
402626003403	DNA binding site [nucleotide binding]
402626003404	domain linker motif; other site
402626003405	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
402626003406	putative dimerization interface [polypeptide binding]; other site
402626003407	putative ligand binding site [chemical binding]; other site
402626003408	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
402626003409	EamA-like transporter family; Region: EamA; pfam00892
402626003410	EamA-like transporter family; Region: EamA; pfam00892
402626003411	Cupin domain; Region: Cupin_2; cl17218
402626003412	Helix-turn-helix domain; Region: HTH_18; pfam12833
402626003413	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626003414	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
402626003415	MarR family; Region: MarR; pfam01047
402626003416	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
402626003417	active site 1 [active]
402626003418	dimer interface [polypeptide binding]; other site
402626003419	hexamer interface [polypeptide binding]; other site
402626003420	active site 2 [active]
402626003421	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
402626003422	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
402626003423	conserved cys residue [active]
402626003424	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626003425	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626003426	active site
402626003427	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
402626003428	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
402626003429	dimer interface [polypeptide binding]; other site
402626003430	active site
402626003431	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626003432	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
402626003433	substrate binding site [chemical binding]; other site
402626003434	oxyanion hole (OAH) forming residues; other site
402626003435	trimer interface [polypeptide binding]; other site
402626003436	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
402626003437	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
402626003438	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
402626003439	Cache domain; Region: Cache_1; pfam02743
402626003440	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626003441	PAS domain; Region: PAS_9; pfam13426
402626003442	putative active site [active]
402626003443	heme pocket [chemical binding]; other site
402626003444	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626003445	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626003446	metal binding site [ion binding]; metal-binding site
402626003447	active site
402626003448	I-site; other site
402626003449	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626003450	Domain of unknown function (DUF305); Region: DUF305; cl17794
402626003451	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
402626003452	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
402626003453	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
402626003454	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
402626003455	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
402626003456	HSP70 interaction site [polypeptide binding]; other site
402626003457	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
402626003458	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
402626003459	HAMP domain; Region: HAMP; pfam00672
402626003460	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626003461	PAS domain; Region: PAS_9; pfam13426
402626003462	putative active site [active]
402626003463	heme pocket [chemical binding]; other site
402626003464	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626003465	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626003466	metal binding site [ion binding]; metal-binding site
402626003467	active site
402626003468	I-site; other site
402626003469	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626003470	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626003471	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626003472	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
402626003473	putative dimerization interface [polypeptide binding]; other site
402626003474	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
402626003475	Coenzyme A transferase; Region: CoA_trans; cl17247
402626003476	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
402626003477	Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082
402626003478	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
402626003479	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
402626003480	Malonate transporter MadL subunit; Region: MadL; cl04273
402626003481	Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
402626003482	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
402626003483	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
402626003484	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
402626003485	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
402626003486	DnaA N-terminal domain; Region: DnaA_N; pfam11638
402626003487	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
402626003488	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626003489	Walker A motif; other site
402626003490	ATP binding site [chemical binding]; other site
402626003491	Walker B motif; other site
402626003492	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
402626003493	arginine finger; other site
402626003494	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
402626003495	DnaA box-binding interface [nucleotide binding]; other site
402626003496	DNA polymerase III subunit beta; Validated; Region: PRK05643
402626003497	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
402626003498	putative DNA binding surface [nucleotide binding]; other site
402626003499	dimer interface [polypeptide binding]; other site
402626003500	beta-clamp/clamp loader binding surface; other site
402626003501	beta-clamp/translesion DNA polymerase binding surface; other site
402626003502	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
402626003503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626003504	ATP binding site [chemical binding]; other site
402626003505	Mg2+ binding site [ion binding]; other site
402626003506	G-X-G motif; other site
402626003507	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
402626003508	anchoring element; other site
402626003509	dimer interface [polypeptide binding]; other site
402626003510	ATP binding site [chemical binding]; other site
402626003511	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
402626003512	active site
402626003513	putative metal-binding site [ion binding]; other site
402626003514	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
402626003515	Methyltransferase domain; Region: Methyltransf_26; pfam13659
402626003516	putative transposase OrfB; Reviewed; Region: PHA02517
402626003517	HTH-like domain; Region: HTH_21; pfam13276
402626003518	Integrase core domain; Region: rve; pfam00665
402626003519	Integrase core domain; Region: rve_3; pfam13683
402626003520	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
402626003521	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
402626003522	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
402626003523	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
402626003524	Transcriptional regulators [Transcription]; Region: FadR; COG2186
402626003525	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626003526	DNA-binding site [nucleotide binding]; DNA binding site
402626003527	FCD domain; Region: FCD; pfam07729
402626003528	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
402626003529	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626003530	substrate binding pocket [chemical binding]; other site
402626003531	membrane-bound complex binding site; other site
402626003532	hinge residues; other site
402626003533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626003534	dimer interface [polypeptide binding]; other site
402626003535	conserved gate region; other site
402626003536	putative PBP binding loops; other site
402626003537	ABC-ATPase subunit interface; other site
402626003538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626003539	dimer interface [polypeptide binding]; other site
402626003540	conserved gate region; other site
402626003541	putative PBP binding loops; other site
402626003542	ABC-ATPase subunit interface; other site
402626003543	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
402626003544	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
402626003545	Walker A/P-loop; other site
402626003546	ATP binding site [chemical binding]; other site
402626003547	Q-loop/lid; other site
402626003548	ABC transporter signature motif; other site
402626003549	Walker B; other site
402626003550	D-loop; other site
402626003551	H-loop/switch region; other site
402626003552	Predicted membrane protein [Function unknown]; Region: COG3781
402626003553	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
402626003554	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
402626003555	ligand binding site [chemical binding]; other site
402626003556	flexible hinge region; other site
402626003557	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
402626003558	non-specific DNA interactions [nucleotide binding]; other site
402626003559	DNA binding site [nucleotide binding]
402626003560	sequence specific DNA binding site [nucleotide binding]; other site
402626003561	putative cAMP binding site [chemical binding]; other site
402626003562	acyl-CoA synthetase; Validated; Region: PRK08162
402626003563	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
402626003564	acyl-activating enzyme (AAE) consensus motif; other site
402626003565	putative active site [active]
402626003566	AMP binding site [chemical binding]; other site
402626003567	putative CoA binding site [chemical binding]; other site
402626003568	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
402626003569	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
402626003570	Uncharacterized conserved protein [Function unknown]; Region: COG2128
402626003571	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
402626003572	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
402626003573	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
402626003574	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
402626003575	DNA binding residues [nucleotide binding]
402626003576	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626003577	dimer interface [polypeptide binding]; other site
402626003578	phosphorylation site [posttranslational modification]
402626003579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626003580	ATP binding site [chemical binding]; other site
402626003581	G-X-G motif; other site
402626003582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626003583	active site
402626003584	phosphorylation site [posttranslational modification]
402626003585	intermolecular recognition site; other site
402626003586	dimerization interface [polypeptide binding]; other site
402626003587	Response regulator receiver domain; Region: Response_reg; pfam00072
402626003588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626003589	active site
402626003590	phosphorylation site [posttranslational modification]
402626003591	intermolecular recognition site; other site
402626003592	dimerization interface [polypeptide binding]; other site
402626003593	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
402626003594	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
402626003595	C-terminal domain interface [polypeptide binding]; other site
402626003596	GSH binding site (G-site) [chemical binding]; other site
402626003597	dimer interface [polypeptide binding]; other site
402626003598	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
402626003599	dimer interface [polypeptide binding]; other site
402626003600	N-terminal domain interface [polypeptide binding]; other site
402626003601	putative substrate binding pocket (H-site) [chemical binding]; other site
402626003602	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
402626003603	HPP family; Region: HPP; pfam04982
402626003604	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
402626003605	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
402626003606	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
402626003607	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
402626003608	Helix-turn-helix domain; Region: HTH_18; pfam12833
402626003609	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
402626003610	GYD domain; Region: GYD; cl01743
402626003611	S-adenosylmethionine synthetase; Validated; Region: PRK05250
402626003612	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
402626003613	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
402626003614	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
402626003615	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
402626003616	putative acyl-acceptor binding pocket; other site
402626003617	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
402626003618	putative acyl-acceptor binding pocket; other site
402626003619	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
402626003620	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
402626003621	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
402626003622	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
402626003623	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
402626003624	active site
402626003625	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
402626003626	putative active site [active]
402626003627	putative catalytic site [active]
402626003628	putative DNA binding site [nucleotide binding]; other site
402626003629	putative phosphate binding site [ion binding]; other site
402626003630	metal binding site A [ion binding]; metal-binding site
402626003631	putative AP binding site [nucleotide binding]; other site
402626003632	putative metal binding site B [ion binding]; other site
402626003633	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
402626003634	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
402626003635	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
402626003636	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cd02106
402626003637	Uncharacterized conserved protein [Function unknown]; Region: COG1434
402626003638	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
402626003639	putative active site [active]
402626003640	Peptidase family M48; Region: Peptidase_M48; cl12018
402626003641	muropeptide transporter; Reviewed; Region: ampG; PRK11902
402626003642	Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000
402626003643	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626003644	Uncharacterized conserved protein [Function unknown]; Region: COG1565
402626003645	short chain dehydrogenase; Provisional; Region: PRK09134
402626003646	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626003647	NAD(P) binding site [chemical binding]; other site
402626003648	active site
402626003649	Dihydroneopterin aldolase; Region: FolB; smart00905
402626003650	active site
402626003651	Arginase family; Region: Arginase; cd09989
402626003652	active site
402626003653	Mn binding site [ion binding]; other site
402626003654	oligomer interface [polypeptide binding]; other site
402626003655	ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854
402626003656	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
402626003657	inhibitor-cofactor binding pocket; inhibition site
402626003658	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626003659	catalytic residue [active]
402626003660	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626003661	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626003662	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
402626003663	dimerization interface [polypeptide binding]; other site
402626003664	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626003665	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626003666	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626003667	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
402626003668	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626003669	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
402626003670	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
402626003671	Walker A/P-loop; other site
402626003672	ATP binding site [chemical binding]; other site
402626003673	Q-loop/lid; other site
402626003674	ABC transporter signature motif; other site
402626003675	Walker B; other site
402626003676	D-loop; other site
402626003677	H-loop/switch region; other site
402626003678	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
402626003679	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
402626003680	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
402626003681	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
402626003682	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
402626003683	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
402626003684	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
402626003685	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
402626003686	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
402626003687	Ligand Binding Site [chemical binding]; other site
402626003688	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
402626003689	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
402626003690	Substrate binding site; other site
402626003691	Mg++ binding site; other site
402626003692	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
402626003693	active site
402626003694	substrate binding site [chemical binding]; other site
402626003695	CoA binding site [chemical binding]; other site
402626003696	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
402626003697	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
402626003698	glutaminase active site [active]
402626003699	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
402626003700	dimer interface [polypeptide binding]; other site
402626003701	active site
402626003702	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
402626003703	dimer interface [polypeptide binding]; other site
402626003704	active site
402626003705	hypothetical protein; Provisional; Region: PRK06834
402626003706	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
402626003707	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
402626003708	active site
402626003709	nucleophile elbow; other site
402626003710	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
402626003711	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
402626003712	putative NAD(P) binding site [chemical binding]; other site
402626003713	dimer interface [polypeptide binding]; other site
402626003714	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626003715	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626003716	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626003717	putative effector binding pocket; other site
402626003718	dimerization interface [polypeptide binding]; other site
402626003719	thiamine pyrophosphate protein; Provisional; Region: PRK08273
402626003720	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
402626003721	PYR/PP interface [polypeptide binding]; other site
402626003722	dimer interface [polypeptide binding]; other site
402626003723	tetramer interface [polypeptide binding]; other site
402626003724	TPP binding site [chemical binding]; other site
402626003725	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
402626003726	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
402626003727	TPP-binding site [chemical binding]; other site
402626003728	Hemerythrin-like domain; Region: Hr-like; cd12108
402626003729	Fe binding site [ion binding]; other site
402626003730	PRC-barrel domain; Region: PRC; pfam05239
402626003731	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
402626003732	dimer interface [polypeptide binding]; other site
402626003733	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626003734	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
402626003735	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626003736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626003737	homodimer interface [polypeptide binding]; other site
402626003738	catalytic residue [active]
402626003739	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626003740	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
402626003741	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626003742	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626003743	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
402626003744	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
402626003745	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626003746	putative substrate translocation pore; other site
402626003747	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
402626003748	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
402626003749	C-terminal domain interface [polypeptide binding]; other site
402626003750	GSH binding site (G-site) [chemical binding]; other site
402626003751	dimer interface [polypeptide binding]; other site
402626003752	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
402626003753	N-terminal domain interface [polypeptide binding]; other site
402626003754	putative dimer interface [polypeptide binding]; other site
402626003755	active site
402626003756	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
402626003757	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
402626003758	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
402626003759	EamA-like transporter family; Region: EamA; pfam00892
402626003760	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626003761	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
402626003762	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626003763	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
402626003764	Bacterial transcriptional activator domain; Region: BTAD; smart01043
402626003765	Lipopolysaccharide-assembly; Region: LptE; cl01125
402626003766	Pollen proteins Ole e I like; Region: Pollen_Ole_e_I; pfam01190
402626003767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
402626003768	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
402626003769	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
402626003770	B12 binding site [chemical binding]; other site
402626003771	cobalt ligand [ion binding]; other site
402626003772	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
402626003773	Walker A; other site
402626003774	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
402626003775	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
402626003776	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
402626003777	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
402626003778	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
402626003779	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626003780	Coenzyme A binding pocket [chemical binding]; other site
402626003781	Uncharacterized conserved protein [Function unknown]; Region: COG5361
402626003782	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
402626003783	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
402626003784	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
402626003785	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
402626003786	FMN binding site [chemical binding]; other site
402626003787	substrate binding site [chemical binding]; other site
402626003788	putative catalytic residue [active]
402626003789	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
402626003790	intracellular protease, PfpI family; Region: PfpI; TIGR01382
402626003791	proposed catalytic triad [active]
402626003792	conserved cys residue [active]
402626003793	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
402626003794	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
402626003795	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
402626003796	Sel1-like repeats; Region: SEL1; smart00671
402626003797	Sel1-like repeats; Region: SEL1; smart00671
402626003798	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
402626003799	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
402626003800	N-terminal plug; other site
402626003801	ligand-binding site [chemical binding]; other site
402626003802	enoyl-CoA hydratase; Provisional; Region: PRK05995
402626003803	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626003804	substrate binding site [chemical binding]; other site
402626003805	oxyanion hole (OAH) forming residues; other site
402626003806	trimer interface [polypeptide binding]; other site
402626003807	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
402626003808	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626003809	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626003810	active site
402626003811	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
402626003812	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626003813	NAD(P) binding site [chemical binding]; other site
402626003814	active site
402626003815	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
402626003816	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626003817	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626003818	active site
402626003819	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
402626003820	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
402626003821	ATP-grasp domain; Region: ATP-grasp_4; cl17255
402626003822	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
402626003823	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
402626003824	carboxyltransferase (CT) interaction site; other site
402626003825	biotinylation site [posttranslational modification]; other site
402626003826	acyl-CoA synthetase; Validated; Region: PRK08316
402626003827	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
402626003828	acyl-activating enzyme (AAE) consensus motif; other site
402626003829	AMP binding site [chemical binding]; other site
402626003830	active site
402626003831	CoA binding site [chemical binding]; other site
402626003832	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626003833	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626003834	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
402626003835	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
402626003836	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
402626003837	putative deacylase active site [active]
402626003838	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
402626003839	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
402626003840	active site
402626003841	catalytic residues [active]
402626003842	metal binding site [ion binding]; metal-binding site
402626003843	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
402626003844	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
402626003845	putative ligand binding site [chemical binding]; other site
402626003846	NAD binding site [chemical binding]; other site
402626003847	dimerization interface [polypeptide binding]; other site
402626003848	catalytic site [active]
402626003849	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
402626003850	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
402626003851	ATP-grasp domain; Region: ATP-grasp_4; cl17255
402626003852	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
402626003853	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
402626003854	carboxyltransferase (CT) interaction site; other site
402626003855	biotinylation site [posttranslational modification]; other site
402626003856	biotin synthase; Region: bioB; TIGR00433
402626003857	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626003858	FeS/SAM binding site; other site
402626003859	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
402626003860	enoyl-CoA hydratase; Provisional; Region: PRK05995
402626003861	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626003862	substrate binding site [chemical binding]; other site
402626003863	oxyanion hole (OAH) forming residues; other site
402626003864	trimer interface [polypeptide binding]; other site
402626003865	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
402626003866	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
402626003867	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
402626003868	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
402626003869	hypothetical protein; Provisional; Region: PRK01842
402626003870	SEC-C motif; Region: SEC-C; pfam02810
402626003871	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
402626003872	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626003873	motif II; other site
402626003874	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
402626003875	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
402626003876	putative catalytic residue [active]
402626003877	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626003878	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626003879	active site
402626003880	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
402626003881	C factor cell-cell signaling protein; Provisional; Region: PRK09009
402626003882	NADP binding site [chemical binding]; other site
402626003883	homodimer interface [polypeptide binding]; other site
402626003884	active site
402626003885	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
402626003886	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
402626003887	dimer interface [polypeptide binding]; other site
402626003888	active site
402626003889	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
402626003890	active site clefts [active]
402626003891	zinc binding site [ion binding]; other site
402626003892	dimer interface [polypeptide binding]; other site
402626003893	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
402626003894	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
402626003895	isovaleryl-CoA dehydrogenase; Region: PLN02519
402626003896	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
402626003897	substrate binding site [chemical binding]; other site
402626003898	FAD binding site [chemical binding]; other site
402626003899	catalytic base [active]
402626003900	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
402626003901	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
402626003902	DNA binding residues [nucleotide binding]
402626003903	putative dimer interface [polypeptide binding]; other site
402626003904	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
402626003905	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
402626003906	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
402626003907	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
402626003908	intersubunit interface [polypeptide binding]; other site
402626003909	short chain dehydrogenase; Provisional; Region: PRK07024
402626003910	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626003911	NAD(P) binding site [chemical binding]; other site
402626003912	active site
402626003913	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
402626003914	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
402626003915	catalytic residues [active]
402626003916	hinge region; other site
402626003917	alpha helical domain; other site
402626003918	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
402626003919	Sporulation related domain; Region: SPOR; pfam05036
402626003920	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
402626003921	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
402626003922	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
402626003923	active site
402626003924	HIGH motif; other site
402626003925	KMSK motif region; other site
402626003926	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
402626003927	tRNA binding surface [nucleotide binding]; other site
402626003928	anticodon binding site; other site
402626003929	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
402626003930	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
402626003931	Ferritin-like domain; Region: Ferritin; pfam00210
402626003932	dinuclear metal binding motif [ion binding]; other site
402626003933	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
402626003934	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626003935	Histidine kinase; Region: HisKA_3; pfam07730
402626003936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626003937	ATP binding site [chemical binding]; other site
402626003938	Mg2+ binding site [ion binding]; other site
402626003939	G-X-G motif; other site
402626003940	Predicted small secreted protein [Function unknown]; Region: COG5510
402626003941	Response regulator receiver domain; Region: Response_reg; pfam00072
402626003942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626003943	active site
402626003944	phosphorylation site [posttranslational modification]
402626003945	intermolecular recognition site; other site
402626003946	dimerization interface [polypeptide binding]; other site
402626003947	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626003948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626003949	active site
402626003950	phosphorylation site [posttranslational modification]
402626003951	intermolecular recognition site; other site
402626003952	dimerization interface [polypeptide binding]; other site
402626003953	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626003954	DNA binding residues [nucleotide binding]
402626003955	dimerization interface [polypeptide binding]; other site
402626003956	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
402626003957	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
402626003958	substrate binding pocket [chemical binding]; other site
402626003959	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
402626003960	B12 binding site [chemical binding]; other site
402626003961	cobalt ligand [ion binding]; other site
402626003962	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
402626003963	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
402626003964	active site
402626003965	metal binding site [ion binding]; metal-binding site
402626003966	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626003967	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
402626003968	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
402626003969	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
402626003970	active site residue [active]
402626003971	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
402626003972	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
402626003973	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
402626003974	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
402626003975	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
402626003976	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
402626003977	Transcriptional regulator [Transcription]; Region: IclR; COG1414
402626003978	Bacterial transcriptional regulator; Region: IclR; pfam01614
402626003979	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
402626003980	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
402626003981	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
402626003982	Transcriptional regulator [Transcription]; Region: IclR; COG1414
402626003983	Bacterial transcriptional regulator; Region: IclR; pfam01614
402626003984	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
402626003985	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
402626003986	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
402626003987	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
402626003988	putative ligand binding site [chemical binding]; other site
402626003989	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
402626003990	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626003991	substrate binding site [chemical binding]; other site
402626003992	oxyanion hole (OAH) forming residues; other site
402626003993	trimer interface [polypeptide binding]; other site
402626003994	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
402626003995	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
402626003996	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
402626003997	active site
402626003998	nucleophile elbow; other site
402626003999	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
402626004000	catalytic residues [active]
402626004001	dimer interface [polypeptide binding]; other site
402626004002	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
402626004003	dinuclear metal binding motif [ion binding]; other site
402626004004	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
402626004005	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
402626004006	active site
402626004007	nucleotide binding site [chemical binding]; other site
402626004008	HIGH motif; other site
402626004009	KMSKS motif; other site
402626004010	Sporulation related domain; Region: SPOR; pfam05036
402626004011	pantothenate kinase; Reviewed; Region: PRK13328
402626004012	biotin--protein ligase; Provisional; Region: PRK06955
402626004013	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
402626004014	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
402626004015	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
402626004016	Permease; Region: Permease; pfam02405
402626004017	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
402626004018	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
402626004019	Walker A/P-loop; other site
402626004020	ATP binding site [chemical binding]; other site
402626004021	Q-loop/lid; other site
402626004022	ABC transporter signature motif; other site
402626004023	Walker B; other site
402626004024	D-loop; other site
402626004025	H-loop/switch region; other site
402626004026	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
402626004027	mce related protein; Region: MCE; pfam02470
402626004028	Predicted integral membrane protein [Function unknown]; Region: COG5652
402626004029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626004030	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626004031	putative substrate translocation pore; other site
402626004032	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
402626004033	IucA / IucC family; Region: IucA_IucC; pfam04183
402626004034	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
402626004035	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
402626004036	Phosphoesterase family; Region: Phosphoesterase; pfam04185
402626004037	Domain of unknown function (DUF756); Region: DUF756; pfam05506
402626004038	Domain of unknown function (DUF756); Region: DUF756; pfam05506
402626004039	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
402626004040	lipoyl synthase; Provisional; Region: PRK05481
402626004041	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626004042	FeS/SAM binding site; other site
402626004043	lipoate-protein ligase B; Provisional; Region: PRK14343
402626004044	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
402626004045	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
402626004046	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626004047	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
402626004048	dimerization interface [polypeptide binding]; other site
402626004049	substrate binding pocket [chemical binding]; other site
402626004050	hypothetical protein; Provisional; Region: PRK02047
402626004051	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
402626004052	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
402626004053	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
402626004054	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
402626004055	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
402626004056	dimer interface [polypeptide binding]; other site
402626004057	[2Fe-2S] cluster binding site [ion binding]; other site
402626004058	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
402626004059	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
402626004060	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
402626004061	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626004062	dimer interface [polypeptide binding]; other site
402626004063	phosphorylation site [posttranslational modification]
402626004064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626004065	ATP binding site [chemical binding]; other site
402626004066	Mg2+ binding site [ion binding]; other site
402626004067	G-X-G motif; other site
402626004068	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
402626004069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626004070	active site
402626004071	phosphorylation site [posttranslational modification]
402626004072	intermolecular recognition site; other site
402626004073	dimerization interface [polypeptide binding]; other site
402626004074	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626004075	Walker A motif; other site
402626004076	ATP binding site [chemical binding]; other site
402626004077	Walker B motif; other site
402626004078	arginine finger; other site
402626004079	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626004080	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
402626004081	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
402626004082	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
402626004083	catalytic residues [active]
402626004084	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
402626004085	putative ADP-ribose binding site [chemical binding]; other site
402626004086	putative active site [active]
402626004087	LysE type translocator; Region: LysE; cl00565
402626004088	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
402626004089	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
402626004090	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
402626004091	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
402626004092	Membrane fusogenic activity; Region: BMFP; pfam04380
402626004093	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
402626004094	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
402626004095	Nitrogen regulatory protein P-II; Region: P-II; smart00938
402626004096	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
402626004097	Glutamate-cysteine ligase; Region: GshA; pfam08886
402626004098	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
402626004099	glutathione synthetase; Provisional; Region: PRK05246
402626004100	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
402626004101	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
402626004102	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
402626004103	active pocket/dimerization site; other site
402626004104	active site
402626004105	phosphorylation site [posttranslational modification]
402626004106	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
402626004107	dimerization domain swap beta strand [polypeptide binding]; other site
402626004108	regulatory protein interface [polypeptide binding]; other site
402626004109	active site
402626004110	regulatory phosphorylation site [posttranslational modification]; other site
402626004111	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
402626004112	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
402626004113	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
402626004114	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
402626004115	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
402626004116	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
402626004117	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
402626004118	heme binding site [chemical binding]; other site
402626004119	ferroxidase pore; other site
402626004120	ferroxidase diiron center [ion binding]; other site
402626004121	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
402626004122	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
402626004123	ATP binding site [chemical binding]; other site
402626004124	substrate interface [chemical binding]; other site
402626004125	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
402626004126	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
402626004127	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
402626004128	protein binding site [polypeptide binding]; other site
402626004129	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
402626004130	Catalytic dyad [active]
402626004131	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
402626004132	catalytic core [active]
402626004133	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
402626004134	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
402626004135	active site residue [active]
402626004136	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
402626004137	GSH binding site [chemical binding]; other site
402626004138	catalytic residues [active]
402626004139	preprotein translocase subunit SecB; Validated; Region: PRK05751
402626004140	SecA binding site; other site
402626004141	Preprotein binding site; other site
402626004142	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
402626004143	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
402626004144	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
402626004145	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
402626004146	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
402626004147	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
402626004148	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626004149	S-adenosylmethionine binding site [chemical binding]; other site
402626004150	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
402626004151	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
402626004152	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
402626004153	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
402626004154	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
402626004155	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
402626004156	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
402626004157	Subunit I/III interface [polypeptide binding]; other site
402626004158	D-pathway; other site
402626004159	Subunit I/VIIc interface [polypeptide binding]; other site
402626004160	Subunit I/IV interface [polypeptide binding]; other site
402626004161	Subunit I/II interface [polypeptide binding]; other site
402626004162	Low-spin heme (heme a) binding site [chemical binding]; other site
402626004163	Subunit I/VIIa interface [polypeptide binding]; other site
402626004164	Subunit I/VIa interface [polypeptide binding]; other site
402626004165	Dimer interface; other site
402626004166	Putative water exit pathway; other site
402626004167	Binuclear center (heme a3/CuB) [ion binding]; other site
402626004168	K-pathway; other site
402626004169	Subunit I/Vb interface [polypeptide binding]; other site
402626004170	Putative proton exit pathway; other site
402626004171	Subunit I/VIb interface; other site
402626004172	Subunit I/VIc interface [polypeptide binding]; other site
402626004173	Electron transfer pathway; other site
402626004174	Subunit I/VIIIb interface [polypeptide binding]; other site
402626004175	Subunit I/VIIb interface [polypeptide binding]; other site
402626004176	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
402626004177	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
402626004178	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
402626004179	Subunit III/VIIa interface [polypeptide binding]; other site
402626004180	Phospholipid binding site [chemical binding]; other site
402626004181	Subunit I/III interface [polypeptide binding]; other site
402626004182	Subunit III/VIb interface [polypeptide binding]; other site
402626004183	Subunit III/VIa interface; other site
402626004184	Subunit III/Vb interface [polypeptide binding]; other site
402626004185	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
402626004186	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
402626004187	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
402626004188	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
402626004189	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
402626004190	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
402626004191	UbiA prenyltransferase family; Region: UbiA; pfam01040
402626004192	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
402626004193	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
402626004194	Cu(I) binding site [ion binding]; other site
402626004195	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
402626004196	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
402626004197	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
402626004198	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
402626004199	DNA binding residues [nucleotide binding]
402626004200	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626004201	PAS domain; Region: PAS_9; pfam13426
402626004202	putative active site [active]
402626004203	heme pocket [chemical binding]; other site
402626004204	PAS fold; Region: PAS_4; pfam08448
402626004205	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626004206	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626004207	metal binding site [ion binding]; metal-binding site
402626004208	active site
402626004209	I-site; other site
402626004210	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
402626004211	Pirin-related protein [General function prediction only]; Region: COG1741
402626004212	Pirin; Region: Pirin; pfam02678
402626004213	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
402626004214	glycosyl transferase family protein; Provisional; Region: PRK08136
402626004215	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
402626004216	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
402626004217	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
402626004218	Walker A/P-loop; other site
402626004219	ATP binding site [chemical binding]; other site
402626004220	Q-loop/lid; other site
402626004221	ABC transporter signature motif; other site
402626004222	Walker B; other site
402626004223	D-loop; other site
402626004224	H-loop/switch region; other site
402626004225	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
402626004226	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626004227	dimer interface [polypeptide binding]; other site
402626004228	conserved gate region; other site
402626004229	putative PBP binding loops; other site
402626004230	ABC-ATPase subunit interface; other site
402626004231	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
402626004232	NMT1-like family; Region: NMT1_2; pfam13379
402626004233	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
402626004234	ANTAR domain; Region: ANTAR; pfam03861
402626004235	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
402626004236	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
402626004237	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
402626004238	maleylacetoacetate isomerase; Region: maiA; TIGR01262
402626004239	C-terminal domain interface [polypeptide binding]; other site
402626004240	GSH binding site (G-site) [chemical binding]; other site
402626004241	putative dimer interface [polypeptide binding]; other site
402626004242	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
402626004243	dimer interface [polypeptide binding]; other site
402626004244	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
402626004245	N-terminal domain interface [polypeptide binding]; other site
402626004246	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
402626004247	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
402626004248	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
402626004249	P loop; other site
402626004250	GTP binding site [chemical binding]; other site
402626004251	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
402626004252	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
402626004253	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
402626004254	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
402626004255	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
402626004256	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
402626004257	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626004258	S-adenosylmethionine binding site [chemical binding]; other site
402626004259	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
402626004260	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
402626004261	active site
402626004262	(T/H)XGH motif; other site
402626004263	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
402626004264	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
402626004265	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
402626004266	putative active site [active]
402626004267	catalytic residue [active]
402626004268	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
402626004269	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
402626004270	5S rRNA interface [nucleotide binding]; other site
402626004271	CTC domain interface [polypeptide binding]; other site
402626004272	L16 interface [polypeptide binding]; other site
402626004273	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
402626004274	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
402626004275	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
402626004276	active site
402626004277	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
402626004278	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
402626004279	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
402626004280	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
402626004281	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
402626004282	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
402626004283	Tetratricopeptide repeat; Region: TPR_16; pfam13432
402626004284	TPR motif; other site
402626004285	binding surface
402626004286	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
402626004287	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
402626004288	binding surface
402626004289	TPR motif; other site
402626004290	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
402626004291	binding surface
402626004292	TPR motif; other site
402626004293	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
402626004294	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
402626004295	DNA binding site [nucleotide binding]
402626004296	catalytic residue [active]
402626004297	H2TH interface [polypeptide binding]; other site
402626004298	putative catalytic residues [active]
402626004299	turnover-facilitating residue; other site
402626004300	intercalation triad [nucleotide binding]; other site
402626004301	8OG recognition residue [nucleotide binding]; other site
402626004302	putative reading head residues; other site
402626004303	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
402626004304	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
402626004305	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
402626004306	G1 box; other site
402626004307	GTP/Mg2+ binding site [chemical binding]; other site
402626004308	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
402626004309	G2 box; other site
402626004310	Switch I region; other site
402626004311	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
402626004312	G3 box; other site
402626004313	Switch II region; other site
402626004314	GTP/Mg2+ binding site [chemical binding]; other site
402626004315	G4 box; other site
402626004316	G5 box; other site
402626004317	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
402626004318	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
402626004319	minor groove reading motif; other site
402626004320	helix-hairpin-helix signature motif; other site
402626004321	substrate binding pocket [chemical binding]; other site
402626004322	active site
402626004323	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
402626004324	DNA binding and oxoG recognition site [nucleotide binding]
402626004325	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
402626004326	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
402626004327	AAA domain; Region: AAA_18; pfam13238
402626004328	psiF repeat; Region: PsiF_repeat; pfam07769
402626004329	hypothetical protein; Provisional; Region: PRK11505
402626004330	HPr kinase/phosphorylase; Provisional; Region: PRK05428
402626004331	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
402626004332	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
402626004333	Hpr binding site; other site
402626004334	active site
402626004335	homohexamer subunit interaction site [polypeptide binding]; other site
402626004336	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
402626004337	active site
402626004338	phosphorylation site [posttranslational modification]
402626004339	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
402626004340	30S subunit binding site; other site
402626004341	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
402626004342	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
402626004343	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
402626004344	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
402626004345	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
402626004346	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
402626004347	Walker A/P-loop; other site
402626004348	ATP binding site [chemical binding]; other site
402626004349	Q-loop/lid; other site
402626004350	ABC transporter signature motif; other site
402626004351	Walker B; other site
402626004352	D-loop; other site
402626004353	H-loop/switch region; other site
402626004354	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
402626004355	OstA-like protein; Region: OstA; pfam03968
402626004356	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
402626004357	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
402626004358	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
402626004359	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
402626004360	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
402626004361	putative active site [active]
402626004362	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
402626004363	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
402626004364	putative cation:proton antiport protein; Provisional; Region: PRK10669
402626004365	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
402626004366	TrkA-N domain; Region: TrkA_N; pfam02254
402626004367	TrkA-C domain; Region: TrkA_C; pfam02080
402626004368	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
402626004369	intracellular protease, PfpI family; Region: PfpI; TIGR01382
402626004370	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
402626004371	conserved cys residue [active]
402626004372	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
402626004373	active site
402626004374	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
402626004375	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
402626004376	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
402626004377	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
402626004378	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
402626004379	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
402626004380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626004381	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626004382	putative substrate translocation pore; other site
402626004383	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
402626004384	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
402626004385	dimer interface [polypeptide binding]; other site
402626004386	ssDNA binding site [nucleotide binding]; other site
402626004387	tetramer (dimer of dimers) interface [polypeptide binding]; other site
402626004388	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
402626004389	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
402626004390	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
402626004391	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
402626004392	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
402626004393	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
402626004394	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
402626004395	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
402626004396	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
402626004397	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
402626004398	GAF domain; Region: GAF; pfam01590
402626004399	PAS domain S-box; Region: sensory_box; TIGR00229
402626004400	PAS domain; Region: PAS; smart00091
402626004401	PAS fold; Region: PAS; pfam00989
402626004402	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626004403	putative active site [active]
402626004404	heme pocket [chemical binding]; other site
402626004405	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626004406	metal binding site [ion binding]; metal-binding site
402626004407	active site
402626004408	I-site; other site
402626004409	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626004410	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
402626004411	Bacterial transcriptional regulator; Region: IclR; pfam01614
402626004412	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626004413	Walker A motif; other site
402626004414	ATP binding site [chemical binding]; other site
402626004415	Walker B motif; other site
402626004416	arginine finger; other site
402626004417	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626004418	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
402626004419	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
402626004420	Cytochrome c553 [Energy production and conversion]; Region: COG2863
402626004421	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
402626004422	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
402626004423	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
402626004424	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
402626004425	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
402626004426	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626004427	FeS/SAM binding site; other site
402626004428	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
402626004429	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
402626004430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626004431	dimer interface [polypeptide binding]; other site
402626004432	phosphorylation site [posttranslational modification]
402626004433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626004434	ATP binding site [chemical binding]; other site
402626004435	Mg2+ binding site [ion binding]; other site
402626004436	G-X-G motif; other site
402626004437	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
402626004438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626004439	active site
402626004440	phosphorylation site [posttranslational modification]
402626004441	intermolecular recognition site; other site
402626004442	dimerization interface [polypeptide binding]; other site
402626004443	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626004444	DNA binding site [nucleotide binding]
402626004445	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
402626004446	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
402626004447	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
402626004448	Moco binding site; other site
402626004449	metal coordination site [ion binding]; other site
402626004450	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
402626004451	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
402626004452	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
402626004453	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
402626004454	catalytic residues [active]
402626004455	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
402626004456	putative active site 1 [active]
402626004457	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
402626004458	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
402626004459	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
402626004460	dimer interface [polypeptide binding]; other site
402626004461	active site
402626004462	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
402626004463	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
402626004464	NodB motif; other site
402626004465	active site
402626004466	catalytic site [active]
402626004467	metal binding site [ion binding]; metal-binding site
402626004468	Predicted exporter [General function prediction only]; Region: COG4258
402626004469	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
402626004470	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
402626004471	putative acyl-acceptor binding pocket; other site
402626004472	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
402626004473	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
402626004474	acyl-activating enzyme (AAE) consensus motif; other site
402626004475	AMP binding site [chemical binding]; other site
402626004476	active site
402626004477	CoA binding site [chemical binding]; other site
402626004478	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
402626004479	active site 2 [active]
402626004480	dimer interface [polypeptide binding]; other site
402626004481	active site 1 [active]
402626004482	Predicted membrane protein [Function unknown]; Region: COG4648
402626004483	acyl carrier protein; Provisional; Region: PRK09184
402626004484	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
402626004485	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
402626004486	Ligand binding site; other site
402626004487	Putative Catalytic site; other site
402626004488	DXD motif; other site
402626004489	Sulphur transport; Region: Sulf_transp; pfam04143
402626004490	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
402626004491	Predicted transporter component [General function prediction only]; Region: COG2391
402626004492	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
402626004493	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
402626004494	ATP-binding site [chemical binding]; other site
402626004495	Gluconate-6-phosphate binding site [chemical binding]; other site
402626004496	Shikimate kinase; Region: SKI; pfam01202
402626004497	AMP-binding domain protein; Validated; Region: PRK08315
402626004498	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
402626004499	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
402626004500	acyl-activating enzyme (AAE) consensus motif; other site
402626004501	putative AMP binding site [chemical binding]; other site
402626004502	putative active site [active]
402626004503	putative CoA binding site [chemical binding]; other site
402626004504	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
402626004505	putative active site [active]
402626004506	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
402626004507	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
402626004508	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
402626004509	threonine dehydratase; Reviewed; Region: PRK09224
402626004510	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
402626004511	tetramer interface [polypeptide binding]; other site
402626004512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626004513	catalytic residue [active]
402626004514	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
402626004515	putative Ile/Val binding site [chemical binding]; other site
402626004516	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
402626004517	putative Ile/Val binding site [chemical binding]; other site
402626004518	Inward rectifier potassium channel; Region: IRK; pfam01007
402626004519	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
402626004520	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
402626004521	Predicted membrane protein [Function unknown]; Region: COG1238
402626004522	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
402626004523	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
402626004524	FAD binding domain; Region: FAD_binding_4; pfam01565
402626004525	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
402626004526	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
402626004527	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
402626004528	Cysteine-rich domain; Region: CCG; pfam02754
402626004529	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
402626004530	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
402626004531	HIT family signature motif; other site
402626004532	catalytic residue [active]
402626004533	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
402626004534	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
402626004535	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
402626004536	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
402626004537	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
402626004538	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626004539	S-adenosylmethionine binding site [chemical binding]; other site
402626004540	Tim44-like domain; Region: Tim44; cl09208
402626004541	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
402626004542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
402626004543	SCP-2 sterol transfer family; Region: SCP2; pfam02036
402626004544	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
402626004545	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
402626004546	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
402626004547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626004548	S-adenosylmethionine binding site [chemical binding]; other site
402626004549	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
402626004550	Na binding site [ion binding]; other site
402626004551	putative glycosylation site [posttranslational modification]; other site
402626004552	putative glycosylation site [posttranslational modification]; other site
402626004553	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331
402626004554	Uncharacterized conserved protein [Function unknown]; Region: COG2928
402626004555	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
402626004556	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
402626004557	dimer interface [polypeptide binding]; other site
402626004558	anticodon binding site; other site
402626004559	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
402626004560	homodimer interface [polypeptide binding]; other site
402626004561	motif 1; other site
402626004562	active site
402626004563	motif 2; other site
402626004564	GAD domain; Region: GAD; pfam02938
402626004565	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
402626004566	motif 3; other site
402626004567	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
402626004568	nudix motif; other site
402626004569	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
402626004570	putative catalytic site [active]
402626004571	putative metal binding site [ion binding]; other site
402626004572	putative phosphate binding site [ion binding]; other site
402626004573	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
402626004574	PLD-like domain; Region: PLDc_2; pfam13091
402626004575	putative active site [active]
402626004576	catalytic site [active]
402626004577	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
402626004578	PLD-like domain; Region: PLDc_2; pfam13091
402626004579	putative active site [active]
402626004580	catalytic site [active]
402626004581	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
402626004582	Coenzyme A transferase; Region: CoA_trans; smart00882
402626004583	Coenzyme A transferase; Region: CoA_trans; cl17247
402626004584	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626004585	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626004586	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
402626004587	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
402626004588	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626004589	active site
402626004590	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
402626004591	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
402626004592	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
402626004593	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
402626004594	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
402626004595	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626004596	substrate binding site [chemical binding]; other site
402626004597	oxyanion hole (OAH) forming residues; other site
402626004598	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
402626004599	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
402626004600	dimer interface [polypeptide binding]; other site
402626004601	active site
402626004602	EDD domain protein, DegV family; Region: DegV; TIGR00762
402626004603	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
402626004604	enoyl-CoA hydratase; Provisional; Region: PRK06688
402626004605	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626004606	substrate binding site [chemical binding]; other site
402626004607	oxyanion hole (OAH) forming residues; other site
402626004608	trimer interface [polypeptide binding]; other site
402626004609	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
402626004610	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
402626004611	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
402626004612	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
402626004613	Walker A/P-loop; other site
402626004614	ATP binding site [chemical binding]; other site
402626004615	Q-loop/lid; other site
402626004616	ABC transporter signature motif; other site
402626004617	Walker B; other site
402626004618	D-loop; other site
402626004619	H-loop/switch region; other site
402626004620	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626004621	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
402626004622	dimerization interface [polypeptide binding]; other site
402626004623	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
402626004624	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
402626004625	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
402626004626	NAD(P) binding site [chemical binding]; other site
402626004627	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
402626004628	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626004629	substrate binding pocket [chemical binding]; other site
402626004630	membrane-bound complex binding site; other site
402626004631	hinge residues; other site
402626004632	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
402626004633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626004634	dimer interface [polypeptide binding]; other site
402626004635	conserved gate region; other site
402626004636	putative PBP binding loops; other site
402626004637	ABC-ATPase subunit interface; other site
402626004638	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
402626004639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626004640	dimer interface [polypeptide binding]; other site
402626004641	conserved gate region; other site
402626004642	putative PBP binding loops; other site
402626004643	ABC-ATPase subunit interface; other site
402626004644	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
402626004645	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
402626004646	Walker A/P-loop; other site
402626004647	ATP binding site [chemical binding]; other site
402626004648	Q-loop/lid; other site
402626004649	ABC transporter signature motif; other site
402626004650	Walker B; other site
402626004651	D-loop; other site
402626004652	H-loop/switch region; other site
402626004653	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
402626004654	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
402626004655	putative active site [active]
402626004656	putative dimer interface [polypeptide binding]; other site
402626004657	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
402626004658	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
402626004659	MOFRL family; Region: MOFRL; pfam05161
402626004660	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
402626004661	active site
402626004662	substrate binding pocket [chemical binding]; other site
402626004663	dimer interface [polypeptide binding]; other site
402626004664	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
402626004665	OsmC-like protein; Region: OsmC; cl00767
402626004666	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
402626004667	23S rRNA interface [nucleotide binding]; other site
402626004668	L3 interface [polypeptide binding]; other site
402626004669	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
402626004670	seryl-tRNA synthetase; Provisional; Region: PRK05431
402626004671	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
402626004672	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
402626004673	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
402626004674	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
402626004675	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
402626004676	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
402626004677	active site
402626004678	HIGH motif; other site
402626004679	dimer interface [polypeptide binding]; other site
402626004680	KMSKS motif; other site
402626004681	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
402626004682	RNA binding surface [nucleotide binding]; other site
402626004683	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
402626004684	putative active site [active]
402626004685	dimerization interface [polypeptide binding]; other site
402626004686	putative tRNAtyr binding site [nucleotide binding]; other site
402626004687	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
402626004688	catalytic core [active]
402626004689	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
402626004690	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
402626004691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626004692	Walker A motif; other site
402626004693	ATP binding site [chemical binding]; other site
402626004694	Walker B motif; other site
402626004695	arginine finger; other site
402626004696	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
402626004697	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
402626004698	RuvA N terminal domain; Region: RuvA_N; pfam01330
402626004699	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
402626004700	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
402626004701	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
402626004702	putative active site [active]
402626004703	catalytic site [active]
402626004704	putative metal binding site [ion binding]; other site
402626004705	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
402626004706	active site
402626004707	putative DNA-binding cleft [nucleotide binding]; other site
402626004708	dimer interface [polypeptide binding]; other site
402626004709	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
402626004710	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
402626004711	purine monophosphate binding site [chemical binding]; other site
402626004712	dimer interface [polypeptide binding]; other site
402626004713	putative catalytic residues [active]
402626004714	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
402626004715	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
402626004716	DNA-binding protein Fis; Provisional; Region: PRK01905
402626004717	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
402626004718	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
402626004719	FMN binding site [chemical binding]; other site
402626004720	active site
402626004721	catalytic residues [active]
402626004722	substrate binding site [chemical binding]; other site
402626004723	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
402626004724	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
402626004725	hydroxyglutarate oxidase; Provisional; Region: PRK11728
402626004726	hypothetical protein; Provisional; Region: PRK06996
402626004727	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
402626004728	proline aminopeptidase P II; Provisional; Region: PRK10879
402626004729	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
402626004730	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
402626004731	active site
402626004732	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
402626004733	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
402626004734	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
402626004735	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626004736	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626004737	metal binding site [ion binding]; metal-binding site
402626004738	active site
402626004739	I-site; other site
402626004740	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626004741	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
402626004742	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
402626004743	Substrate binding site; other site
402626004744	metal-binding site
402626004745	Predicted membrane protein [Function unknown]; Region: COG4392
402626004746	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
402626004747	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
402626004748	Phosphotransferase enzyme family; Region: APH; pfam01636
402626004749	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
402626004750	OstA-like protein; Region: OstA; cl00844
402626004751	Organic solvent tolerance protein; Region: OstA_C; pfam04453
402626004752	SurA N-terminal domain; Region: SurA_N; pfam09312
402626004753	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
402626004754	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
402626004755	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909
402626004756	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
402626004757	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
402626004758	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
402626004759	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
402626004760	EamA-like transporter family; Region: EamA; pfam00892
402626004761	EamA-like transporter family; Region: EamA; pfam00892
402626004762	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626004763	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
402626004764	dimer interface [polypeptide binding]; other site
402626004765	active site
402626004766	metal binding site [ion binding]; metal-binding site
402626004767	glutathione binding site [chemical binding]; other site
402626004768	Protein of unknown function DUF45; Region: DUF45; pfam01863
402626004769	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
402626004770	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
402626004771	putative acyl-acceptor binding pocket; other site
402626004772	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
402626004773	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626004774	active site
402626004775	motif I; other site
402626004776	motif II; other site
402626004777	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
402626004778	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
402626004779	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
402626004780	dimer interface [polypeptide binding]; other site
402626004781	motif 1; other site
402626004782	active site
402626004783	motif 2; other site
402626004784	motif 3; other site
402626004785	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
402626004786	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
402626004787	putative active site [active]
402626004788	catalytic triad [active]
402626004789	putative dimer interface [polypeptide binding]; other site
402626004790	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
402626004791	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
402626004792	Transporter associated domain; Region: CorC_HlyC; smart01091
402626004793	unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963
402626004794	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
402626004795	PhoH-like protein; Region: PhoH; pfam02562
402626004796	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
402626004797	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
402626004798	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626004799	FeS/SAM binding site; other site
402626004800	TRAM domain; Region: TRAM; pfam01938
402626004801	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
402626004802	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
402626004803	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
402626004804	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
402626004805	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
402626004806	acyl-activating enzyme (AAE) consensus motif; other site
402626004807	putative AMP binding site [chemical binding]; other site
402626004808	putative active site [active]
402626004809	putative CoA binding site [chemical binding]; other site
402626004810	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
402626004811	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
402626004812	dimer interface [polypeptide binding]; other site
402626004813	active site
402626004814	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
402626004815	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
402626004816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626004817	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626004818	NAD(P) binding site [chemical binding]; other site
402626004819	active site
402626004820	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
402626004821	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626004822	active site
402626004823	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
402626004824	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626004825	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626004826	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
402626004827	DEAD-like helicases superfamily; Region: DEXDc; smart00487
402626004828	ATP binding site [chemical binding]; other site
402626004829	Mg++ binding site [ion binding]; other site
402626004830	motif III; other site
402626004831	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
402626004832	nucleotide binding region [chemical binding]; other site
402626004833	ATP-binding site [chemical binding]; other site
402626004834	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
402626004835	serine/threonine protein kinase; Provisional; Region: PRK11768
402626004836	Pirin-related protein [General function prediction only]; Region: COG1741
402626004837	Pirin; Region: Pirin; pfam02678
402626004838	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
402626004839	LysR family transcriptional regulator; Provisional; Region: PRK14997
402626004840	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626004841	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626004842	putative effector binding pocket; other site
402626004843	dimerization interface [polypeptide binding]; other site
402626004844	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
402626004845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626004846	active site
402626004847	phosphorylation site [posttranslational modification]
402626004848	intermolecular recognition site; other site
402626004849	dimerization interface [polypeptide binding]; other site
402626004850	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626004851	DNA binding site [nucleotide binding]
402626004852	Cupin domain; Region: Cupin_2; pfam07883
402626004853	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
402626004854	hypothetical protein; Provisional; Region: PRK07236
402626004855	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626004856	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626004857	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
402626004858	dimerization interface [polypeptide binding]; other site
402626004859	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910
402626004860	putative active site [active]
402626004861	Zn binding site [ion binding]; other site
402626004862	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626004863	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626004864	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
402626004865	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
402626004866	PGAP1-like protein; Region: PGAP1; pfam07819
402626004867	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
402626004868	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
402626004869	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
402626004870	active site
402626004871	DNA binding site [nucleotide binding]
402626004872	Int/Topo IB signature motif; other site
402626004873	AAA domain; Region: AAA_31; pfam13614
402626004874	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
402626004875	P-loop; other site
402626004876	Magnesium ion binding site [ion binding]; other site
402626004877	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
402626004878	Magnesium ion binding site [ion binding]; other site
402626004879	Restriction endonuclease; Region: Mrr_cat; pfam04471
402626004880	Replicase family; Region: Replicase; pfam03090
402626004881	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
402626004882	ParB-like nuclease domain; Region: ParB; smart00470
402626004883	MT-A70; Region: MT-A70; cl01947
402626004884	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
402626004885	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
402626004886	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
402626004887	ATP binding site [chemical binding]; other site
402626004888	putative Mg++ binding site [ion binding]; other site
402626004889	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
402626004890	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
402626004891	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
402626004892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626004893	Walker B; other site
402626004894	D-loop; other site
402626004895	H-loop/switch region; other site
402626004896	HsdM N-terminal domain; Region: HsdM_N; pfam12161
402626004897	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
402626004898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626004899	S-adenosylmethionine binding site [chemical binding]; other site
402626004900	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
402626004901	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
402626004902	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
402626004903	non-specific DNA binding site [nucleotide binding]; other site
402626004904	salt bridge; other site
402626004905	sequence-specific DNA binding site [nucleotide binding]; other site
402626004906	Autoinducer binding domain; Region: Autoind_bind; pfam03472
402626004907	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626004908	DNA binding residues [nucleotide binding]
402626004909	dimerization interface [polypeptide binding]; other site
402626004910	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
402626004911	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
402626004912	Int/Topo IB signature motif; other site
402626004913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626004914	putative substrate translocation pore; other site
402626004915	Protein of unknown function, DUF485; Region: DUF485; pfam04341
402626004916	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
402626004917	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
402626004918	Na binding site [ion binding]; other site
402626004919	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
402626004920	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
402626004921	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
402626004922	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
402626004923	metal binding triad; other site
402626004924	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
402626004925	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
402626004926	active site
402626004927	catalytic site [active]
402626004928	substrate binding site [chemical binding]; other site
402626004929	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
402626004930	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
402626004931	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626004932	HAMP domain; Region: HAMP; pfam00672
402626004933	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626004934	dimer interface [polypeptide binding]; other site
402626004935	phosphorylation site [posttranslational modification]
402626004936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626004937	ATP binding site [chemical binding]; other site
402626004938	Mg2+ binding site [ion binding]; other site
402626004939	G-X-G motif; other site
402626004940	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
402626004941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626004942	active site
402626004943	phosphorylation site [posttranslational modification]
402626004944	intermolecular recognition site; other site
402626004945	dimerization interface [polypeptide binding]; other site
402626004946	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626004947	DNA binding site [nucleotide binding]
402626004948	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
402626004949	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
402626004950	hexamer interface [polypeptide binding]; other site
402626004951	Walker A motif; other site
402626004952	ATP binding site [chemical binding]; other site
402626004953	Walker B motif; other site
402626004954	recombination regulator RecX; Reviewed; Region: recX; PRK00117
402626004955	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
402626004956	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
402626004957	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
402626004958	CoA-ligase; Region: Ligase_CoA; pfam00549
402626004959	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
402626004960	CoA binding domain; Region: CoA_binding; smart00881
402626004961	CoA-ligase; Region: Ligase_CoA; pfam00549
402626004962	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
402626004963	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
402626004964	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
402626004965	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
402626004966	O-Antigen ligase; Region: Wzy_C; pfam04932
402626004967	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
402626004968	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
402626004969	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
402626004970	Pilin (bacterial filament); Region: Pilin; pfam00114
402626004971	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
402626004972	trimer interface [polypeptide binding]; other site
402626004973	dimer interface [polypeptide binding]; other site
402626004974	putative active site [active]
402626004975	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
402626004976	Peptidase family M48; Region: Peptidase_M48; pfam01435
402626004977	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
402626004978	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
402626004979	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
402626004980	SnoaL-like domain; Region: SnoaL_3; pfam13474
402626004981	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
402626004982	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
402626004983	putative active site [active]
402626004984	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
402626004985	AzlC protein; Region: AzlC; pfam03591
402626004986	Predicted membrane protein [Function unknown]; Region: COG4392
402626004987	Predicted permeases [General function prediction only]; Region: RarD; COG2962
402626004988	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
402626004989	Phosphoglycerate kinase; Region: PGK; pfam00162
402626004990	substrate binding site [chemical binding]; other site
402626004991	hinge regions; other site
402626004992	ADP binding site [chemical binding]; other site
402626004993	catalytic site [active]
402626004994	pyruvate kinase; Provisional; Region: PRK05826
402626004995	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
402626004996	domain interfaces; other site
402626004997	active site
402626004998	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
402626004999	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
402626005000	intersubunit interface [polypeptide binding]; other site
402626005001	active site
402626005002	zinc binding site [ion binding]; other site
402626005003	Na+ binding site [ion binding]; other site
402626005004	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
402626005005	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
402626005006	ATP binding site [chemical binding]; other site
402626005007	active site
402626005008	substrate binding site [chemical binding]; other site
402626005009	AIR carboxylase; Region: AIRC; pfam00731
402626005010	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
402626005011	ATP-grasp domain; Region: ATP-grasp; pfam02222
402626005012	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
402626005013	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
402626005014	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
402626005015	active site
402626005016	catalytic triad [active]
402626005017	oxyanion hole [active]
402626005018	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
402626005019	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
402626005020	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
402626005021	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
402626005022	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
402626005023	active site
402626005024	DNA binding site [nucleotide binding]
402626005025	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
402626005026	DNA binding site [nucleotide binding]
402626005027	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
402626005028	nucleotide binding site [chemical binding]; other site
402626005029	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
402626005030	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
402626005031	putative DNA binding site [nucleotide binding]; other site
402626005032	putative homodimer interface [polypeptide binding]; other site
402626005033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626005034	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626005035	putative substrate translocation pore; other site
402626005036	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
402626005037	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
402626005038	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
402626005039	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
402626005040	active site
402626005041	PAS domain S-box; Region: sensory_box; TIGR00229
402626005042	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626005043	putative active site [active]
402626005044	heme pocket [chemical binding]; other site
402626005045	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
402626005046	GAF domain; Region: GAF; pfam01590
402626005047	PAS fold; Region: PAS; pfam00989
402626005048	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626005049	putative active site [active]
402626005050	heme pocket [chemical binding]; other site
402626005051	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626005052	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626005053	metal binding site [ion binding]; metal-binding site
402626005054	active site
402626005055	I-site; other site
402626005056	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626005057	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
402626005058	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626005059	dimer interface [polypeptide binding]; other site
402626005060	putative CheW interface [polypeptide binding]; other site
402626005061	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
402626005062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626005063	putative substrate translocation pore; other site
402626005064	amidase; Provisional; Region: PRK07056
402626005065	Amidase; Region: Amidase; cl11426
402626005066	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
402626005067	Transcriptional regulators [Transcription]; Region: GntR; COG1802
402626005068	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626005069	DNA-binding site [nucleotide binding]; DNA binding site
402626005070	FCD domain; Region: FCD; pfam07729
402626005071	hypothetical protein; Provisional; Region: PRK07538
402626005072	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
402626005073	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
402626005074	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
402626005075	putative ligand binding site [chemical binding]; other site
402626005076	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
402626005077	MarR family; Region: MarR; pfam01047
402626005078	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
402626005079	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
402626005080	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
402626005081	Zn2+ binding site [ion binding]; other site
402626005082	Mg2+ binding site [ion binding]; other site
402626005083	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
402626005084	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
402626005085	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
402626005086	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626005087	DNA-binding site [nucleotide binding]; DNA binding site
402626005088	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626005089	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626005090	homodimer interface [polypeptide binding]; other site
402626005091	catalytic residue [active]
402626005092	Protein of unknown function (DUF330); Region: DUF330; pfam03886
402626005093	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
402626005094	mce related protein; Region: MCE; pfam02470
402626005095	mce related protein; Region: MCE; pfam02470
402626005096	mce related protein; Region: MCE; pfam02470
402626005097	Paraquat-inducible protein A; Region: PqiA; pfam04403
402626005098	Paraquat-inducible protein A; Region: PqiA; pfam04403
402626005099	S-formylglutathione hydrolase; Region: PLN02442
402626005100	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
402626005101	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
402626005102	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
402626005103	substrate binding site [chemical binding]; other site
402626005104	catalytic Zn binding site [ion binding]; other site
402626005105	NAD binding site [chemical binding]; other site
402626005106	structural Zn binding site [ion binding]; other site
402626005107	dimer interface [polypeptide binding]; other site
402626005108	Cache domain; Region: Cache_1; pfam02743
402626005109	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626005110	dimerization interface [polypeptide binding]; other site
402626005111	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
402626005112	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626005113	dimer interface [polypeptide binding]; other site
402626005114	putative CheW interface [polypeptide binding]; other site
402626005115	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
402626005116	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
402626005117	putative C-terminal domain interface [polypeptide binding]; other site
402626005118	putative GSH binding site (G-site) [chemical binding]; other site
402626005119	putative dimer interface [polypeptide binding]; other site
402626005120	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
402626005121	dimer interface [polypeptide binding]; other site
402626005122	N-terminal domain interface [polypeptide binding]; other site
402626005123	putative substrate binding pocket (H-site) [chemical binding]; other site
402626005124	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626005125	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626005126	metal binding site [ion binding]; metal-binding site
402626005127	active site
402626005128	I-site; other site
402626005129	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
402626005130	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
402626005131	Domain of unknown function DUF20; Region: UPF0118; pfam01594
402626005132	Uncharacterized conserved protein [Function unknown]; Region: COG3268
402626005133	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626005134	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
402626005135	tetramer interface [polypeptide binding]; other site
402626005136	active site
402626005137	Mg2+/Mn2+ binding site [ion binding]; other site
402626005138	isocitrate lyase; Region: PLN02892
402626005139	citrate-proton symporter; Provisional; Region: PRK15075
402626005140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626005141	putative substrate translocation pore; other site
402626005142	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
402626005143	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
402626005144	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626005145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626005146	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
402626005147	putative dimerization interface [polypeptide binding]; other site
402626005148	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626005149	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626005150	metal binding site [ion binding]; metal-binding site
402626005151	active site
402626005152	I-site; other site
402626005153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626005154	NmrA-like family; Region: NmrA; pfam05368
402626005155	NAD(P) binding site [chemical binding]; other site
402626005156	active site
402626005157	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626005158	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626005159	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626005160	putative effector binding pocket; other site
402626005161	dimerization interface [polypeptide binding]; other site
402626005162	glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; Region: glu_cys_lig_rel; TIGR01435
402626005163	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
402626005164	classical (c) SDRs; Region: SDR_c; cd05233
402626005165	NAD(P) binding site [chemical binding]; other site
402626005166	active site
402626005167	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
402626005168	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
402626005169	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
402626005170	BNR repeat-like domain; Region: BNR_2; pfam13088
402626005171	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
402626005172	Na binding site [ion binding]; other site
402626005173	Protein of unknown function, DUF1537; Region: DUF1537; pfam07005
402626005174	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
402626005175	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
402626005176	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
402626005177	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
402626005178	putative active site [active]
402626005179	metal binding site [ion binding]; metal-binding site
402626005180	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
402626005181	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
402626005182	inhibitor site; inhibition site
402626005183	active site
402626005184	dimer interface [polypeptide binding]; other site
402626005185	catalytic residue [active]
402626005186	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
402626005187	putative metal binding site [ion binding]; other site
402626005188	putative homodimer interface [polypeptide binding]; other site
402626005189	putative homotetramer interface [polypeptide binding]; other site
402626005190	putative homodimer-homodimer interface [polypeptide binding]; other site
402626005191	putative allosteric switch controlling residues; other site
402626005192	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
402626005193	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
402626005194	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
402626005195	Dihaem cytochrome c; Region: DHC; pfam09626
402626005196	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
402626005197	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
402626005198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626005199	active site
402626005200	phosphorylation site [posttranslational modification]
402626005201	intermolecular recognition site; other site
402626005202	dimerization interface [polypeptide binding]; other site
402626005203	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626005204	DNA binding site [nucleotide binding]
402626005205	sensor protein QseC; Provisional; Region: PRK10337
402626005206	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626005207	dimer interface [polypeptide binding]; other site
402626005208	phosphorylation site [posttranslational modification]
402626005209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626005210	ATP binding site [chemical binding]; other site
402626005211	Mg2+ binding site [ion binding]; other site
402626005212	G-X-G motif; other site
402626005213	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
402626005214	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
402626005215	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
402626005216	oligomerisation interface [polypeptide binding]; other site
402626005217	mobile loop; other site
402626005218	roof hairpin; other site
402626005219	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
402626005220	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
402626005221	ring oligomerisation interface [polypeptide binding]; other site
402626005222	ATP/Mg binding site [chemical binding]; other site
402626005223	stacking interactions; other site
402626005224	hinge regions; other site
402626005225	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
402626005226	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
402626005227	Predicted membrane protein [Function unknown]; Region: COG2246
402626005228	GtrA-like protein; Region: GtrA; pfam04138
402626005229	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
402626005230	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
402626005231	TadE-like protein; Region: TadE; pfam07811
402626005232	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
402626005233	TadE-like protein; Region: TadE; pfam07811
402626005234	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
402626005235	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
402626005236	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
402626005237	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
402626005238	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
402626005239	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
402626005240	ATP binding site [chemical binding]; other site
402626005241	Walker A motif; other site
402626005242	hexamer interface [polypeptide binding]; other site
402626005243	Walker B motif; other site
402626005244	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
402626005245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626005246	active site
402626005247	dimerization interface [polypeptide binding]; other site
402626005248	AAA domain; Region: AAA_31; pfam13614
402626005249	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
402626005250	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
402626005251	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
402626005252	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
402626005253	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
402626005254	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
402626005255	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
402626005256	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
402626005257	Walker A motif; other site
402626005258	ATP binding site [chemical binding]; other site
402626005259	Walker B motif; other site
402626005260	arginine finger; other site
402626005261	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
402626005262	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
402626005263	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
402626005264	Flp/Fap pilin component; Region: Flp_Fap; cl01585
402626005265	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
402626005266	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
402626005267	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
402626005268	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
402626005269	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
402626005270	Ligand binding site; other site
402626005271	Putative Catalytic site; other site
402626005272	DXD motif; other site
402626005273	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
402626005274	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
402626005275	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
402626005276	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
402626005277	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626005278	Walker A motif; other site
402626005279	ATP binding site [chemical binding]; other site
402626005280	Walker B motif; other site
402626005281	arginine finger; other site
402626005282	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
402626005283	Repair protein; Region: Repair_PSII; cl01535
402626005284	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
402626005285	Repair protein; Region: Repair_PSII; pfam04536
402626005286	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
402626005287	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
402626005288	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
402626005289	dimer interface [polypeptide binding]; other site
402626005290	active site
402626005291	catalytic residue [active]
402626005292	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
402626005293	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
402626005294	inhibitor-cofactor binding pocket; inhibition site
402626005295	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626005296	catalytic residue [active]
402626005297	Rubredoxin [Energy production and conversion]; Region: COG1773
402626005298	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
402626005299	iron binding site [ion binding]; other site
402626005300	Response regulator receiver domain; Region: Response_reg; pfam00072
402626005301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626005302	active site
402626005303	phosphorylation site [posttranslational modification]
402626005304	intermolecular recognition site; other site
402626005305	dimerization interface [polypeptide binding]; other site
402626005306	Response regulator receiver domain; Region: Response_reg; pfam00072
402626005307	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626005308	active site
402626005309	phosphorylation site [posttranslational modification]
402626005310	intermolecular recognition site; other site
402626005311	dimerization interface [polypeptide binding]; other site
402626005312	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
402626005313	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
402626005314	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
402626005315	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626005316	dimer interface [polypeptide binding]; other site
402626005317	putative CheW interface [polypeptide binding]; other site
402626005318	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
402626005319	putative binding surface; other site
402626005320	active site
402626005321	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
402626005322	putative binding surface; other site
402626005323	active site
402626005324	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
402626005325	putative binding surface; other site
402626005326	active site
402626005327	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
402626005328	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
402626005329	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626005330	ATP binding site [chemical binding]; other site
402626005331	Mg2+ binding site [ion binding]; other site
402626005332	G-X-G motif; other site
402626005333	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
402626005334	Response regulator receiver domain; Region: Response_reg; pfam00072
402626005335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626005336	active site
402626005337	phosphorylation site [posttranslational modification]
402626005338	intermolecular recognition site; other site
402626005339	dimerization interface [polypeptide binding]; other site
402626005340	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
402626005341	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
402626005342	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
402626005343	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
402626005344	RNA binding surface [nucleotide binding]; other site
402626005345	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
402626005346	active site
402626005347	uracil binding [chemical binding]; other site
402626005348	hypothetical protein; Validated; Region: PRK00228
402626005349	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
402626005350	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
402626005351	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
402626005352	active site
402626005353	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
402626005354	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
402626005355	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
402626005356	dihydroorotase; Provisional; Region: PRK07627
402626005357	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
402626005358	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
402626005359	active site
402626005360	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
402626005361	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
402626005362	putative acyl-acceptor binding pocket; other site
402626005363	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
402626005364	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
402626005365	active site
402626005366	metal binding site [ion binding]; metal-binding site
402626005367	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
402626005368	Chain length determinant protein; Region: Wzz; cl15801
402626005369	Chain length determinant protein; Region: Wzz; cl15801
402626005370	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
402626005371	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
402626005372	Mg++ binding site [ion binding]; other site
402626005373	putative catalytic motif [active]
402626005374	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
402626005375	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
402626005376	active site
402626005377	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
402626005378	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
402626005379	Ligand binding site; other site
402626005380	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
402626005381	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
402626005382	active site
402626005383	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
402626005384	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
402626005385	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
402626005386	inhibitor-cofactor binding pocket; inhibition site
402626005387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626005388	catalytic residue [active]
402626005389	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
402626005390	putative trimer interface [polypeptide binding]; other site
402626005391	putative CoA binding site [chemical binding]; other site
402626005392	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
402626005393	putative trimer interface [polypeptide binding]; other site
402626005394	putative active site [active]
402626005395	putative substrate binding site [chemical binding]; other site
402626005396	putative CoA binding site [chemical binding]; other site
402626005397	WxcM-like, C-terminal; Region: FdtA; pfam05523
402626005398	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
402626005399	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
402626005400	NADP binding site [chemical binding]; other site
402626005401	active site
402626005402	putative substrate binding site [chemical binding]; other site
402626005403	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
402626005404	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
402626005405	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
402626005406	substrate binding site; other site
402626005407	tetramer interface; other site
402626005408	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
402626005409	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
402626005410	NAD binding site [chemical binding]; other site
402626005411	substrate binding site [chemical binding]; other site
402626005412	homodimer interface [polypeptide binding]; other site
402626005413	active site
402626005414	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
402626005415	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
402626005416	active site
402626005417	substrate binding site [chemical binding]; other site
402626005418	metal binding site [ion binding]; metal-binding site
402626005419	lipopolysaccharide heptosyltransferase I; Region: heptsyl_trn_I; TIGR02193
402626005420	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
402626005421	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
402626005422	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
402626005423	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
402626005424	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
402626005425	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
402626005426	active site residue [active]
402626005427	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
402626005428	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626005429	S-adenosylmethionine binding site [chemical binding]; other site
402626005430	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626005431	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626005432	Flagellin N-methylase; Region: FliB; cl00497
402626005433	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
402626005434	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
402626005435	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
402626005436	active site
402626005437	FMN binding site [chemical binding]; other site
402626005438	substrate binding site [chemical binding]; other site
402626005439	homotetramer interface [polypeptide binding]; other site
402626005440	catalytic residue [active]
402626005441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626005442	S-adenosylmethionine binding site [chemical binding]; other site
402626005443	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
402626005444	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
402626005445	acyl-activating enzyme (AAE) consensus motif; other site
402626005446	putative AMP binding site [chemical binding]; other site
402626005447	putative active site [active]
402626005448	putative CoA binding site [chemical binding]; other site
402626005449	succinic semialdehyde dehydrogenase; Region: PLN02278
402626005450	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
402626005451	tetramerization interface [polypeptide binding]; other site
402626005452	NAD(P) binding site [chemical binding]; other site
402626005453	catalytic residues [active]
402626005454	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
402626005455	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
402626005456	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
402626005457	N-acetyl-D-glucosamine binding site [chemical binding]; other site
402626005458	catalytic residue [active]
402626005459	aminotransferase; Validated; Region: PRK07337
402626005460	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626005461	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626005462	homodimer interface [polypeptide binding]; other site
402626005463	catalytic residue [active]
402626005464	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
402626005465	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
402626005466	homopentamer interface [polypeptide binding]; other site
402626005467	active site
402626005468	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
402626005469	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
402626005470	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
402626005471	dimerization interface [polypeptide binding]; other site
402626005472	active site
402626005473	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
402626005474	Lumazine binding domain; Region: Lum_binding; pfam00677
402626005475	Lumazine binding domain; Region: Lum_binding; pfam00677
402626005476	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
402626005477	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
402626005478	catalytic motif [active]
402626005479	Zn binding site [ion binding]; other site
402626005480	RibD C-terminal domain; Region: RibD_C; cl17279
402626005481	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
402626005482	Type II transport protein GspH; Region: GspH; pfam12019
402626005483	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
402626005484	Acylphosphatase; Region: Acylphosphatase; cl00551
402626005485	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
402626005486	Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681
402626005487	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
402626005488	Type II transport protein GspH; Region: GspH; pfam12019
402626005489	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
402626005490	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
402626005491	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
402626005492	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
402626005493	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
402626005494	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
402626005495	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
402626005496	ATP cone domain; Region: ATP-cone; pfam03477
402626005497	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
402626005498	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
402626005499	dimer interface [polypeptide binding]; other site
402626005500	active site
402626005501	glycine-pyridoxal phosphate binding site [chemical binding]; other site
402626005502	folate binding site [chemical binding]; other site
402626005503	malonic semialdehyde reductase; Provisional; Region: PRK10538
402626005504	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626005505	NAD(P) binding site [chemical binding]; other site
402626005506	active site
402626005507	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
402626005508	active site
402626005509	TolQ protein; Region: tolQ; TIGR02796
402626005510	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
402626005511	TolR protein; Region: tolR; TIGR02801
402626005512	TolA protein; Region: tolA_full; TIGR02794
402626005513	TolA protein; Region: tolA_full; TIGR02794
402626005514	TonB C terminal; Region: TonB_2; pfam13103
402626005515	translocation protein TolB; Provisional; Region: tolB; PRK02889
402626005516	TolB amino-terminal domain; Region: TolB_N; pfam04052
402626005517	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
402626005518	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
402626005519	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
402626005520	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
402626005521	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
402626005522	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
402626005523	ligand binding site [chemical binding]; other site
402626005524	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
402626005525	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
402626005526	Ligand Binding Site [chemical binding]; other site
402626005527	Predicted transporter component [General function prediction only]; Region: COG2391
402626005528	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
402626005529	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
402626005530	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
402626005531	substrate binding site [chemical binding]; other site
402626005532	ATP binding site [chemical binding]; other site
402626005533	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626005534	D-galactonate transporter; Region: 2A0114; TIGR00893
402626005535	putative substrate translocation pore; other site
402626005536	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
402626005537	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
402626005538	dimerization interface [polypeptide binding]; other site
402626005539	ligand binding site [chemical binding]; other site
402626005540	NADP binding site [chemical binding]; other site
402626005541	catalytic site [active]
402626005542	Transcriptional regulators [Transcription]; Region: PurR; COG1609
402626005543	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
402626005544	DNA binding site [nucleotide binding]
402626005545	domain linker motif; other site
402626005546	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
402626005547	putative ligand binding site [chemical binding]; other site
402626005548	putative dimerization interface [polypeptide binding]; other site
402626005549	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
402626005550	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
402626005551	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
402626005552	Flavin binding site [chemical binding]; other site
402626005553	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
402626005554	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
402626005555	active site
402626005556	iron coordination sites [ion binding]; other site
402626005557	substrate binding pocket [chemical binding]; other site
402626005558	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
402626005559	nudix motif; other site
402626005560	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
402626005561	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
402626005562	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626005563	Walker A/P-loop; other site
402626005564	ATP binding site [chemical binding]; other site
402626005565	Q-loop/lid; other site
402626005566	ABC transporter signature motif; other site
402626005567	Walker B; other site
402626005568	D-loop; other site
402626005569	H-loop/switch region; other site
402626005570	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
402626005571	Predicted membrane protein [Function unknown]; Region: COG5393
402626005572	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
402626005573	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
402626005574	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
402626005575	dimer interface [polypeptide binding]; other site
402626005576	decamer (pentamer of dimers) interface [polypeptide binding]; other site
402626005577	catalytic triad [active]
402626005578	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
402626005579	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
402626005580	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626005581	FAD binding site [chemical binding]; other site
402626005582	substrate binding pocket [chemical binding]; other site
402626005583	catalytic base [active]
402626005584	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
402626005585	Transcriptional regulator [Transcription]; Region: IclR; COG1414
402626005586	Bacterial transcriptional regulator; Region: IclR; pfam01614
402626005587	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
402626005588	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
402626005589	kynureninase; Region: kynureninase; TIGR01814
402626005590	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
402626005591	catalytic residue [active]
402626005592	arylformamidase; Region: trp_arylform; TIGR03035
402626005593	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
402626005594	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626005595	putative DNA binding site [nucleotide binding]; other site
402626005596	putative Zn2+ binding site [ion binding]; other site
402626005597	AsnC family; Region: AsnC_trans_reg; pfam01037
402626005598	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
402626005599	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
402626005600	methionine sulfoxide reductase A; Provisional; Region: PRK14054
402626005601	Protein of unknown function DUF72; Region: DUF72; cl00777
402626005602	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
402626005603	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626005604	S-adenosylmethionine binding site [chemical binding]; other site
402626005605	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
402626005606	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
402626005607	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
402626005608	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
402626005609	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
402626005610	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
402626005611	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
402626005612	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
402626005613	Cytochrome c; Region: Cytochrom_C; pfam00034
402626005614	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
402626005615	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
402626005616	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
402626005617	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
402626005618	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
402626005619	putative ATP binding site [chemical binding]; other site
402626005620	putative substrate interface [chemical binding]; other site
402626005621	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
402626005622	catalytic residues [active]
402626005623	Hemerythrin; Region: Hemerythrin; cd12107
402626005624	Fe binding site [ion binding]; other site
402626005625	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
402626005626	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
402626005627	catalytic residues [active]
402626005628	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
402626005629	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
402626005630	catalytic residues [active]
402626005631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
402626005632	binding surface
402626005633	TPR motif; other site
402626005634	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
402626005635	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
402626005636	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
402626005637	acyl-activating enzyme (AAE) consensus motif; other site
402626005638	putative AMP binding site [chemical binding]; other site
402626005639	putative active site [active]
402626005640	putative CoA binding site [chemical binding]; other site
402626005641	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
402626005642	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
402626005643	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
402626005644	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
402626005645	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
402626005646	putative active site pocket [active]
402626005647	dimerization interface [polypeptide binding]; other site
402626005648	putative catalytic residue [active]
402626005649	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
402626005650	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
402626005651	YaeQ protein; Region: YaeQ; pfam07152
402626005652	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
402626005653	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
402626005654	Protein of unknown function (DUF3999); Region: DUF3999; pfam13163
402626005655	Predicted membrane protein [Function unknown]; Region: COG3686
402626005656	S4 domain; Region: S4_2; cl17325
402626005657	Uncharacterized conserved protein [Function unknown]; Region: COG2353
402626005658	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
402626005659	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
402626005660	active site
402626005661	HIGH motif; other site
402626005662	nucleotide binding site [chemical binding]; other site
402626005663	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
402626005664	KMSKS motif; other site
402626005665	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
402626005666	lipase chaperone; Provisional; Region: PRK01294
402626005667	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
402626005668	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
402626005669	Putative serine esterase (DUF676); Region: DUF676; pfam05057
402626005670	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
402626005671	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
402626005672	Predicted membrane protein [Function unknown]; Region: COG3556
402626005673	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
402626005674	CoA-transferase family III; Region: CoA_transf_3; pfam02515
402626005675	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
402626005676	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
402626005677	motif 1; other site
402626005678	active site
402626005679	motif 2; other site
402626005680	motif 3; other site
402626005681	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
402626005682	DHHA1 domain; Region: DHHA1; pfam02272
402626005683	Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042
402626005684	Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042
402626005685	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
402626005686	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
402626005687	N-terminal plug; other site
402626005688	ligand-binding site [chemical binding]; other site
402626005689	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
402626005690	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
402626005691	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
402626005692	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
402626005693	active site residues [active]
402626005694	dimer interface [polypeptide binding]; other site
402626005695	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
402626005696	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626005697	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626005698	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626005699	dimerization interface [polypeptide binding]; other site
402626005700	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626005701	putative substrate translocation pore; other site
402626005702	aldolase II superfamily protein; Provisional; Region: PRK07044
402626005703	intersubunit interface [polypeptide binding]; other site
402626005704	active site
402626005705	Zn2+ binding site [ion binding]; other site
402626005706	4-oxalocrotonate tautomerase; Provisional; Region: PRK00745
402626005707	active site 1 [active]
402626005708	dimer interface [polypeptide binding]; other site
402626005709	hexamer interface [polypeptide binding]; other site
402626005710	active site 2 [active]
402626005711	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
402626005712	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
402626005713	tetramer interface [polypeptide binding]; other site
402626005714	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626005715	catalytic residue [active]
402626005716	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
402626005717	nudix motif; other site
402626005718	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
402626005719	CPxP  motif; other site
402626005720	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
402626005721	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
402626005722	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
402626005723	generic binding surface I; other site
402626005724	generic binding surface II; other site
402626005725	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
402626005726	putative active site [active]
402626005727	putative catalytic site [active]
402626005728	putative Mg binding site IVb [ion binding]; other site
402626005729	putative phosphate binding site [ion binding]; other site
402626005730	putative DNA binding site [nucleotide binding]; other site
402626005731	putative Mg binding site IVa [ion binding]; other site
402626005732	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
402626005733	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626005734	substrate binding pocket [chemical binding]; other site
402626005735	membrane-bound complex binding site; other site
402626005736	hinge residues; other site
402626005737	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626005738	dimer interface [polypeptide binding]; other site
402626005739	phosphorylation site [posttranslational modification]
402626005740	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626005741	ATP binding site [chemical binding]; other site
402626005742	Mg2+ binding site [ion binding]; other site
402626005743	G-X-G motif; other site
402626005744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626005745	active site
402626005746	phosphorylation site [posttranslational modification]
402626005747	intermolecular recognition site; other site
402626005748	dimerization interface [polypeptide binding]; other site
402626005749	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
402626005750	putative binding surface; other site
402626005751	active site
402626005752	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
402626005753	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
402626005754	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
402626005755	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
402626005756	PapC N-terminal domain; Region: PapC_N; pfam13954
402626005757	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
402626005758	PapC C-terminal domain; Region: PapC_C; pfam13953
402626005759	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
402626005760	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
402626005761	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
402626005762	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
402626005763	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
402626005764	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
402626005765	phosphoglycolate phosphatase; Provisional; Region: PRK13222
402626005766	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626005767	motif II; other site
402626005768	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
402626005769	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626005770	S-adenosylmethionine binding site [chemical binding]; other site
402626005771	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
402626005772	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
402626005773	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
402626005774	ligand binding site [chemical binding]; other site
402626005775	DNA gyrase subunit A; Validated; Region: PRK05560
402626005776	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
402626005777	CAP-like domain; other site
402626005778	active site
402626005779	primary dimer interface [polypeptide binding]; other site
402626005780	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
402626005781	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
402626005782	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
402626005783	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
402626005784	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
402626005785	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
402626005786	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
402626005787	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
402626005788	homodimer interface [polypeptide binding]; other site
402626005789	substrate-cofactor binding pocket; other site
402626005790	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626005791	catalytic residue [active]
402626005792	Chorismate mutase type II; Region: CM_2; cl00693
402626005793	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
402626005794	Prephenate dehydratase; Region: PDT; pfam00800
402626005795	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
402626005796	putative L-Phe binding site [chemical binding]; other site
402626005797	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
402626005798	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626005799	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626005800	homodimer interface [polypeptide binding]; other site
402626005801	catalytic residue [active]
402626005802	prephenate dehydrogenase; Validated; Region: PRK08507
402626005803	Prephenate dehydrogenase; Region: PDH; pfam02153
402626005804	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
402626005805	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
402626005806	hinge; other site
402626005807	active site
402626005808	cytidylate kinase; Provisional; Region: cmk; PRK00023
402626005809	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
402626005810	CMP-binding site; other site
402626005811	The sites determining sugar specificity; other site
402626005812	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
402626005813	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
402626005814	RNA binding site [nucleotide binding]; other site
402626005815	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
402626005816	RNA binding site [nucleotide binding]; other site
402626005817	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
402626005818	RNA binding site [nucleotide binding]; other site
402626005819	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
402626005820	RNA binding site [nucleotide binding]; other site
402626005821	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
402626005822	RNA binding site [nucleotide binding]; other site
402626005823	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
402626005824	RNA binding site [nucleotide binding]; other site
402626005825	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
402626005826	IHF dimer interface [polypeptide binding]; other site
402626005827	IHF - DNA interface [nucleotide binding]; other site
402626005828	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
402626005829	tetratricopeptide repeat protein; Provisional; Region: PRK11788
402626005830	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
402626005831	binding surface
402626005832	TPR motif; other site
402626005833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
402626005834	binding surface
402626005835	TPR motif; other site
402626005836	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
402626005837	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
402626005838	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
402626005839	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
402626005840	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
402626005841	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
402626005842	putative ribose interaction site [chemical binding]; other site
402626005843	putative ADP binding site [chemical binding]; other site
402626005844	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
402626005845	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
402626005846	NADP binding site [chemical binding]; other site
402626005847	homopentamer interface [polypeptide binding]; other site
402626005848	substrate binding site [chemical binding]; other site
402626005849	active site
402626005850	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
402626005851	cysteine synthase B; Region: cysM; TIGR01138
402626005852	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
402626005853	dimer interface [polypeptide binding]; other site
402626005854	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626005855	catalytic residue [active]
402626005856	Transglycosylase SLT domain; Region: SLT_2; pfam13406
402626005857	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
402626005858	N-acetyl-D-glucosamine binding site [chemical binding]; other site
402626005859	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
402626005860	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
402626005861	putative active site [active]
402626005862	Zn binding site [ion binding]; other site
402626005863	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
402626005864	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
402626005865	Walker A/P-loop; other site
402626005866	ATP binding site [chemical binding]; other site
402626005867	Q-loop/lid; other site
402626005868	ABC transporter signature motif; other site
402626005869	Walker B; other site
402626005870	D-loop; other site
402626005871	H-loop/switch region; other site
402626005872	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
402626005873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626005874	dimer interface [polypeptide binding]; other site
402626005875	conserved gate region; other site
402626005876	ABC-ATPase subunit interface; other site
402626005877	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
402626005878	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
402626005879	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
402626005880	Ligand binding site [chemical binding]; other site
402626005881	Electron transfer flavoprotein domain; Region: ETF; pfam01012
402626005882	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
402626005883	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
402626005884	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
402626005885	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
402626005886	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626005887	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626005888	active site
402626005889	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
402626005890	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
402626005891	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
402626005892	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
402626005893	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
402626005894	AsnC family; Region: AsnC_trans_reg; pfam01037
402626005895	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
402626005896	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
402626005897	putative active site [active]
402626005898	putative metal binding site [ion binding]; other site
402626005899	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
402626005900	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
402626005901	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626005902	FeS/SAM binding site; other site
402626005903	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
402626005904	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
402626005905	RimM N-terminal domain; Region: RimM; pfam01782
402626005906	PRC-barrel domain; Region: PRC; pfam05239
402626005907	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
402626005908	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
402626005909	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
402626005910	putative active site [active]
402626005911	putative CoA binding site [chemical binding]; other site
402626005912	nudix motif; other site
402626005913	metal binding site [ion binding]; metal-binding site
402626005914	CobD/CbiB family protein; Provisional; Region: PRK07630
402626005915	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
402626005916	GTPase RsgA; Reviewed; Region: PRK00098
402626005917	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
402626005918	RNA binding site [nucleotide binding]; other site
402626005919	homodimer interface [polypeptide binding]; other site
402626005920	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
402626005921	GTPase/Zn-binding domain interface [polypeptide binding]; other site
402626005922	GTP/Mg2+ binding site [chemical binding]; other site
402626005923	G4 box; other site
402626005924	G5 box; other site
402626005925	G1 box; other site
402626005926	Switch I region; other site
402626005927	G2 box; other site
402626005928	G3 box; other site
402626005929	Switch II region; other site
402626005930	Peptidase family M48; Region: Peptidase_M48; cl12018
402626005931	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
402626005932	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
402626005933	catalytic site [active]
402626005934	putative active site [active]
402626005935	putative substrate binding site [chemical binding]; other site
402626005936	dimer interface [polypeptide binding]; other site
402626005937	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
402626005938	MPT binding site; other site
402626005939	trimer interface [polypeptide binding]; other site
402626005940	hypothetical protein; Provisional; Region: PRK05255
402626005941	peptidase PmbA; Provisional; Region: PRK11040
402626005942	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
402626005943	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
402626005944	folate binding site [chemical binding]; other site
402626005945	NADP+ binding site [chemical binding]; other site
402626005946	thymidylate synthase; Reviewed; Region: thyA; PRK01827
402626005947	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
402626005948	dimerization interface [polypeptide binding]; other site
402626005949	active site
402626005950	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
402626005951	hypothetical protein; Provisional; Region: PRK06815
402626005952	tetramer interface [polypeptide binding]; other site
402626005953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626005954	catalytic residue [active]
402626005955	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
402626005956	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
402626005957	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
402626005958	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
402626005959	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
402626005960	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
402626005961	helicase 45; Provisional; Region: PTZ00424
402626005962	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
402626005963	ATP binding site [chemical binding]; other site
402626005964	Mg++ binding site [ion binding]; other site
402626005965	motif III; other site
402626005966	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
402626005967	nucleotide binding region [chemical binding]; other site
402626005968	ATP-binding site [chemical binding]; other site
402626005969	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
402626005970	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626005971	substrate binding pocket [chemical binding]; other site
402626005972	membrane-bound complex binding site; other site
402626005973	hinge residues; other site
402626005974	ABC transporter ATPase component; Reviewed; Region: PRK11147
402626005975	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626005976	Walker A/P-loop; other site
402626005977	ATP binding site [chemical binding]; other site
402626005978	Q-loop/lid; other site
402626005979	ABC transporter signature motif; other site
402626005980	Walker B; other site
402626005981	D-loop; other site
402626005982	H-loop/switch region; other site
402626005983	ABC transporter; Region: ABC_tran_2; pfam12848
402626005984	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
402626005985	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
402626005986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626005987	ATP binding site [chemical binding]; other site
402626005988	Mg2+ binding site [ion binding]; other site
402626005989	G-X-G motif; other site
402626005990	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
402626005991	anchoring element; other site
402626005992	dimer interface [polypeptide binding]; other site
402626005993	ATP binding site [chemical binding]; other site
402626005994	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
402626005995	active site
402626005996	metal binding site [ion binding]; metal-binding site
402626005997	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
402626005998	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
402626005999	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
402626006000	N-acetyl-D-glucosamine binding site [chemical binding]; other site
402626006001	catalytic residue [active]
402626006002	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
402626006003	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
402626006004	CAP-like domain; other site
402626006005	active site
402626006006	primary dimer interface [polypeptide binding]; other site
402626006007	Chromate transporter; Region: Chromate_transp; pfam02417
402626006008	Chromate transporter; Region: Chromate_transp; pfam02417
402626006009	putative proline-specific permease; Provisional; Region: proY; PRK10580
402626006010	citrate-proton symporter; Provisional; Region: PRK15075
402626006011	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626006012	putative substrate translocation pore; other site
402626006013	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
402626006014	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
402626006015	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
402626006016	Walker A/P-loop; other site
402626006017	ATP binding site [chemical binding]; other site
402626006018	Q-loop/lid; other site
402626006019	ABC transporter signature motif; other site
402626006020	Walker B; other site
402626006021	D-loop; other site
402626006022	H-loop/switch region; other site
402626006023	L-lactate permease; Region: Lactate_perm; cl00701
402626006024	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
402626006025	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
402626006026	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
402626006027	active site
402626006028	nucleophile elbow; other site
402626006029	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
402626006030	Surface antigen; Region: Bac_surface_Ag; pfam01103
402626006031	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
402626006032	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
402626006033	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
402626006034	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
402626006035	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
402626006036	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
402626006037	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
402626006038	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626006039	multidrug efflux protein; Reviewed; Region: PRK09577
402626006040	Protein export membrane protein; Region: SecD_SecF; cl14618
402626006041	Esterase/lipase [General function prediction only]; Region: COG1647
402626006042	MASE1; Region: MASE1; cl17823
402626006043	PAS fold; Region: PAS_3; pfam08447
402626006044	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
402626006045	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
402626006046	putative C-terminal domain interface [polypeptide binding]; other site
402626006047	putative GSH binding site (G-site) [chemical binding]; other site
402626006048	putative dimer interface [polypeptide binding]; other site
402626006049	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
402626006050	putative N-terminal domain interface [polypeptide binding]; other site
402626006051	putative dimer interface [polypeptide binding]; other site
402626006052	putative substrate binding pocket (H-site) [chemical binding]; other site
402626006053	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
402626006054	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626006055	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626006056	homodimer interface [polypeptide binding]; other site
402626006057	catalytic residue [active]
402626006058	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
402626006059	homotrimer interaction site [polypeptide binding]; other site
402626006060	putative active site [active]
402626006061	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
402626006062	EamA-like transporter family; Region: EamA; pfam00892
402626006063	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
402626006064	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
402626006065	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
402626006066	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626006067	DNA-binding site [nucleotide binding]; DNA binding site
402626006068	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626006069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626006070	homodimer interface [polypeptide binding]; other site
402626006071	catalytic residue [active]
402626006072	heat shock protein 90; Provisional; Region: PRK05218
402626006073	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626006074	ATP binding site [chemical binding]; other site
402626006075	Mg2+ binding site [ion binding]; other site
402626006076	G-X-G motif; other site
402626006077	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
402626006078	putative active site [active]
402626006079	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
402626006080	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626006081	substrate binding pocket [chemical binding]; other site
402626006082	membrane-bound complex binding site; other site
402626006083	hinge residues; other site
402626006084	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
402626006085	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
402626006086	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
402626006087	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626006088	putative CheW interface [polypeptide binding]; other site
402626006089	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3812
402626006090	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
402626006091	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
402626006092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626006093	S-adenosylmethionine binding site [chemical binding]; other site
402626006094	SnoaL-like domain; Region: SnoaL_2; pfam12680
402626006095	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
402626006096	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
402626006097	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
402626006098	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
402626006099	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626006100	Walker A motif; other site
402626006101	ATP binding site [chemical binding]; other site
402626006102	Walker B motif; other site
402626006103	arginine finger; other site
402626006104	Cytochrome c; Region: Cytochrom_C; cl11414
402626006105	Cytochrome c553 [Energy production and conversion]; Region: COG2863
402626006106	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
402626006107	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
402626006108	EamA-like transporter family; Region: EamA; pfam00892
402626006109	EamA-like transporter family; Region: EamA; pfam00892
402626006110	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
402626006111	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
402626006112	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
402626006113	putative FMN binding site [chemical binding]; other site
402626006114	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
402626006115	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
402626006116	minor groove reading motif; other site
402626006117	helix-hairpin-helix signature motif; other site
402626006118	substrate binding pocket [chemical binding]; other site
402626006119	active site
402626006120	ferredoxin; Provisional; Region: PRK06991
402626006121	Putative Fe-S cluster; Region: FeS; pfam04060
402626006122	4Fe-4S binding domain; Region: Fer4; pfam00037
402626006123	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626006124	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626006125	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
402626006126	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
402626006127	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
402626006128	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626006129	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626006130	homodimer interface [polypeptide binding]; other site
402626006131	catalytic residue [active]
402626006132	excinuclease ABC subunit B; Provisional; Region: PRK05298
402626006133	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
402626006134	ATP binding site [chemical binding]; other site
402626006135	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
402626006136	nucleotide binding region [chemical binding]; other site
402626006137	ATP-binding site [chemical binding]; other site
402626006138	Ultra-violet resistance protein B; Region: UvrB; pfam12344
402626006139	UvrB/uvrC motif; Region: UVR; pfam02151
402626006140	Site-specific recombinase; Region: SpecificRecomb; cl15411
402626006141	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
402626006142	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
402626006143	substrate binding site [chemical binding]; other site
402626006144	dimer interface [polypeptide binding]; other site
402626006145	ATP binding site [chemical binding]; other site
402626006146	Transcriptional regulators [Transcription]; Region: PurR; COG1609
402626006147	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
402626006148	DNA binding site [nucleotide binding]
402626006149	domain linker motif; other site
402626006150	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
402626006151	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626006152	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
402626006153	TM-ABC transporter signature motif; other site
402626006154	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
402626006155	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
402626006156	Walker A/P-loop; other site
402626006157	ATP binding site [chemical binding]; other site
402626006158	Q-loop/lid; other site
402626006159	ABC transporter signature motif; other site
402626006160	Walker B; other site
402626006161	D-loop; other site
402626006162	H-loop/switch region; other site
402626006163	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
402626006164	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
402626006165	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
402626006166	ligand binding site [chemical binding]; other site
402626006167	Predicted transcriptional regulator [Transcription]; Region: COG1959
402626006168	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
402626006169	cysteine desulfurase; Provisional; Region: PRK14012
402626006170	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
402626006171	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
402626006172	catalytic residue [active]
402626006173	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
402626006174	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
402626006175	trimerization site [polypeptide binding]; other site
402626006176	active site
402626006177	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
402626006178	Protein of unknown function (DUF3565); Region: DUF3565; pfam12088
402626006179	co-chaperone HscB; Provisional; Region: hscB; PRK03578
402626006180	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
402626006181	HSP70 interaction site [polypeptide binding]; other site
402626006182	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
402626006183	chaperone protein HscA; Provisional; Region: hscA; PRK05183
402626006184	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
402626006185	nucleotide binding site [chemical binding]; other site
402626006186	putative NEF/HSP70 interaction site [polypeptide binding]; other site
402626006187	SBD interface [polypeptide binding]; other site
402626006188	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
402626006189	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626006190	catalytic loop [active]
402626006191	iron binding site [ion binding]; other site
402626006192	Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123
402626006193	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
402626006194	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
402626006195	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
402626006196	dimer interface [polypeptide binding]; other site
402626006197	putative anticodon binding site; other site
402626006198	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
402626006199	motif 1; other site
402626006200	active site
402626006201	motif 2; other site
402626006202	motif 3; other site
402626006203	short chain dehydrogenase; Provisional; Region: PRK07023
402626006204	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
402626006205	NADP binding site [chemical binding]; other site
402626006206	homodimer interface [polypeptide binding]; other site
402626006207	active site
402626006208	peptide chain release factor 2; Validated; Region: prfB; PRK00578
402626006209	This domain is found in peptide chain release factors; Region: PCRF; smart00937
402626006210	RF-1 domain; Region: RF-1; pfam00472
402626006211	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
402626006212	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
402626006213	active site
402626006214	Uncharacterized conserved protein [Function unknown]; Region: COG1556
402626006215	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
402626006216	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
402626006217	transmembrane helices; other site
402626006218	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
402626006219	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
402626006220	dimerization interface [polypeptide binding]; other site
402626006221	ligand binding site [chemical binding]; other site
402626006222	NADP binding site [chemical binding]; other site
402626006223	catalytic site [active]
402626006224	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
402626006225	RmuC family; Region: RmuC; pfam02646
402626006226	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
402626006227	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
402626006228	dimer interface [polypeptide binding]; other site
402626006229	putative functional site; other site
402626006230	putative MPT binding site; other site
402626006231	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
402626006232	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
402626006233	GTP binding site; other site
402626006234	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
402626006235	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626006236	FeS/SAM binding site; other site
402626006237	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
402626006238	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
402626006239	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
402626006240	homodimer interface [polypeptide binding]; other site
402626006241	oligonucleotide binding site [chemical binding]; other site
402626006242	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
402626006243	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
402626006244	RNA binding surface [nucleotide binding]; other site
402626006245	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
402626006246	active site
402626006247	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
402626006248	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626006249	motif II; other site
402626006250	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
402626006251	iron-sulfur cluster [ion binding]; other site
402626006252	[2Fe-2S] cluster binding site [ion binding]; other site
402626006253	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
402626006254	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
402626006255	tandem repeat interface [polypeptide binding]; other site
402626006256	oligomer interface [polypeptide binding]; other site
402626006257	active site residues [active]
402626006258	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
402626006259	putative SAM binding site [chemical binding]; other site
402626006260	homodimer interface [polypeptide binding]; other site
402626006261	Maf-like protein; Region: Maf; pfam02545
402626006262	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
402626006263	active site
402626006264	dimer interface [polypeptide binding]; other site
402626006265	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
402626006266	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
402626006267	putative phosphate acyltransferase; Provisional; Region: PRK05331
402626006268	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
402626006269	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
402626006270	dimer interface [polypeptide binding]; other site
402626006271	active site
402626006272	CoA binding pocket [chemical binding]; other site
402626006273	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
402626006274	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
402626006275	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
402626006276	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
402626006277	NAD(P) binding site [chemical binding]; other site
402626006278	homotetramer interface [polypeptide binding]; other site
402626006279	homodimer interface [polypeptide binding]; other site
402626006280	active site
402626006281	acyl carrier protein; Provisional; Region: acpP; PRK00982
402626006282	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
402626006283	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
402626006284	dimer interface [polypeptide binding]; other site
402626006285	active site
402626006286	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
402626006287	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
402626006288	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
402626006289	DNA binding residues [nucleotide binding]
402626006290	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
402626006291	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
402626006292	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
402626006293	anti-sigma E factor; Provisional; Region: rseB; PRK09455
402626006294	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
402626006295	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
402626006296	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
402626006297	protein binding site [polypeptide binding]; other site
402626006298	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
402626006299	protein binding site [polypeptide binding]; other site
402626006300	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
402626006301	GTP-binding protein LepA; Provisional; Region: PRK05433
402626006302	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
402626006303	G1 box; other site
402626006304	putative GEF interaction site [polypeptide binding]; other site
402626006305	GTP/Mg2+ binding site [chemical binding]; other site
402626006306	Switch I region; other site
402626006307	G2 box; other site
402626006308	G3 box; other site
402626006309	Switch II region; other site
402626006310	G4 box; other site
402626006311	G5 box; other site
402626006312	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
402626006313	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
402626006314	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
402626006315	signal peptidase I; Provisional; Region: PRK10861
402626006316	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
402626006317	Catalytic site [active]
402626006318	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
402626006319	ribonuclease III; Reviewed; Region: rnc; PRK00102
402626006320	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
402626006321	dimerization interface [polypeptide binding]; other site
402626006322	active site
402626006323	metal binding site [ion binding]; metal-binding site
402626006324	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
402626006325	dsRNA binding site [nucleotide binding]; other site
402626006326	GTPase Era; Reviewed; Region: era; PRK00089
402626006327	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
402626006328	G1 box; other site
402626006329	GTP/Mg2+ binding site [chemical binding]; other site
402626006330	Switch I region; other site
402626006331	G2 box; other site
402626006332	Switch II region; other site
402626006333	G3 box; other site
402626006334	G4 box; other site
402626006335	G5 box; other site
402626006336	KH domain; Region: KH_2; pfam07650
402626006337	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
402626006338	Recombination protein O N terminal; Region: RecO_N; pfam11967
402626006339	Recombination protein O C terminal; Region: RecO_C; pfam02565
402626006340	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
402626006341	active site
402626006342	hydrophilic channel; other site
402626006343	dimerization interface [polypeptide binding]; other site
402626006344	catalytic residues [active]
402626006345	active site lid [active]
402626006346	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
402626006347	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
402626006348	beta-hexosaminidase; Provisional; Region: PRK05337
402626006349	elongation factor P; Validated; Region: PRK00529
402626006350	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
402626006351	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
402626006352	RNA binding site [nucleotide binding]; other site
402626006353	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
402626006354	RNA binding site [nucleotide binding]; other site
402626006355	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
402626006356	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
402626006357	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
402626006358	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
402626006359	GIY-YIG motif/motif A; other site
402626006360	active site
402626006361	catalytic site [active]
402626006362	putative DNA binding site [nucleotide binding]; other site
402626006363	metal binding site [ion binding]; metal-binding site
402626006364	UvrB/uvrC motif; Region: UVR; pfam02151
402626006365	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
402626006366	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
402626006367	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
402626006368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626006369	active site
402626006370	phosphorylation site [posttranslational modification]
402626006371	intermolecular recognition site; other site
402626006372	dimerization interface [polypeptide binding]; other site
402626006373	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626006374	DNA binding site [nucleotide binding]
402626006375	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
402626006376	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
402626006377	FecR protein; Region: FecR; pfam04773
402626006378	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
402626006379	CHASE2 domain; Region: CHASE2; pfam05226
402626006380	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
402626006381	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626006382	putative active site [active]
402626006383	heme pocket [chemical binding]; other site
402626006384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626006385	dimer interface [polypeptide binding]; other site
402626006386	phosphorylation site [posttranslational modification]
402626006387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626006388	ATP binding site [chemical binding]; other site
402626006389	G-X-G motif; other site
402626006390	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
402626006391	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626006392	DNA binding site [nucleotide binding]
402626006393	Transcriptional regulators [Transcription]; Region: FadR; COG2186
402626006394	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626006395	DNA-binding site [nucleotide binding]; DNA binding site
402626006396	FCD domain; Region: FCD; pfam07729
402626006397	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
402626006398	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
402626006399	active site
402626006400	tetramer interface [polypeptide binding]; other site
402626006401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626006402	D-galactonate transporter; Region: 2A0114; TIGR00893
402626006403	putative substrate translocation pore; other site
402626006404	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
402626006405	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
402626006406	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
402626006407	putative active site [active]
402626006408	putative catalytic site [active]
402626006409	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626006410	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626006411	trimer interface [polypeptide binding]; other site
402626006412	eyelet of channel; other site
402626006413	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
402626006414	active site
402626006415	catalytic residues [active]
402626006416	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
402626006417	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626006418	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
402626006419	putative dimerization interface [polypeptide binding]; other site
402626006420	Predicted membrane protein [Function unknown]; Region: COG2855
402626006421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312
402626006422	Ferredoxin [Energy production and conversion]; Region: COG1146
402626006423	4Fe-4S binding domain; Region: Fer4; cl02805
402626006424	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
402626006425	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
402626006426	DHH family; Region: DHH; pfam01368
402626006427	DHHA1 domain; Region: DHHA1; pfam02272
402626006428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
402626006429	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
402626006430	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
402626006431	FtsX-like permease family; Region: FtsX; pfam02687
402626006432	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
402626006433	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
402626006434	Walker A/P-loop; other site
402626006435	ATP binding site [chemical binding]; other site
402626006436	Q-loop/lid; other site
402626006437	ABC transporter signature motif; other site
402626006438	Walker B; other site
402626006439	D-loop; other site
402626006440	H-loop/switch region; other site
402626006441	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
402626006442	active site
402626006443	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
402626006444	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
402626006445	Competence protein; Region: Competence; pfam03772
402626006446	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
402626006447	Uncharacterized conserved protein [Function unknown]; Region: COG2308
402626006448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
402626006449	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
402626006450	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
402626006451	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
402626006452	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
402626006453	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
402626006454	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
402626006455	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
402626006456	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
402626006457	CTP synthetase; Validated; Region: pyrG; PRK05380
402626006458	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
402626006459	Catalytic site [active]
402626006460	active site
402626006461	UTP binding site [chemical binding]; other site
402626006462	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
402626006463	active site
402626006464	putative oxyanion hole; other site
402626006465	catalytic triad [active]
402626006466	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
402626006467	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
402626006468	Uncharacterized conserved protein [Function unknown]; Region: COG5470
402626006469	enolase; Provisional; Region: eno; PRK00077
402626006470	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
402626006471	dimer interface [polypeptide binding]; other site
402626006472	metal binding site [ion binding]; metal-binding site
402626006473	substrate binding pocket [chemical binding]; other site
402626006474	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
402626006475	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
402626006476	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
402626006477	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
402626006478	dimerization interface [polypeptide binding]; other site
402626006479	domain crossover interface; other site
402626006480	redox-dependent activation switch; other site
402626006481	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
402626006482	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
402626006483	trimer interface [polypeptide binding]; other site
402626006484	putative metal binding site [ion binding]; other site
402626006485	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
402626006486	dinuclear metal binding motif [ion binding]; other site
402626006487	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
402626006488	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
402626006489	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
402626006490	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
402626006491	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
402626006492	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
402626006493	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
402626006494	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
402626006495	active site
402626006496	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
402626006497	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
402626006498	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
402626006499	Peptidase family M50; Region: Peptidase_M50; pfam02163
402626006500	active site
402626006501	putative substrate binding region [chemical binding]; other site
402626006502	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
402626006503	active site
402626006504	HIGH motif; other site
402626006505	dimer interface [polypeptide binding]; other site
402626006506	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
402626006507	active site
402626006508	KMSKS motif; other site
402626006509	Methyltransferase domain; Region: Methyltransf_23; pfam13489
402626006510	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626006511	S-adenosylmethionine binding site [chemical binding]; other site
402626006512	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
402626006513	dihydrodipicolinate synthase; Region: dapA; TIGR00674
402626006514	dimer interface [polypeptide binding]; other site
402626006515	active site
402626006516	catalytic residue [active]
402626006517	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
402626006518	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
402626006519	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
402626006520	Uncharacterized conserved protein [Function unknown]; Region: COG2850
402626006521	Cupin-like domain; Region: Cupin_8; pfam13621
402626006522	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
402626006523	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
402626006524	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
402626006525	MutS domain I; Region: MutS_I; pfam01624
402626006526	MutS domain II; Region: MutS_II; pfam05188
402626006527	MutS domain III; Region: MutS_III; pfam05192
402626006528	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
402626006529	Walker A/P-loop; other site
402626006530	ATP binding site [chemical binding]; other site
402626006531	Q-loop/lid; other site
402626006532	ABC transporter signature motif; other site
402626006533	Walker B; other site
402626006534	D-loop; other site
402626006535	H-loop/switch region; other site
402626006536	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626006537	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626006538	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626006539	dimerization interface [polypeptide binding]; other site
402626006540	Cache domain; Region: Cache_2; pfam08269
402626006541	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
402626006542	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626006543	dimer interface [polypeptide binding]; other site
402626006544	putative CheW interface [polypeptide binding]; other site
402626006545	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
402626006546	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
402626006547	dimer interface [polypeptide binding]; other site
402626006548	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626006549	dimerization interface [polypeptide binding]; other site
402626006550	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626006551	dimer interface [polypeptide binding]; other site
402626006552	putative CheW interface [polypeptide binding]; other site
402626006553	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
402626006554	MOSC domain; Region: MOSC; pfam03473
402626006555	3-alpha domain; Region: 3-alpha; pfam03475
402626006556	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
402626006557	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
402626006558	catalytic triad [active]
402626006559	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
402626006560	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
402626006561	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
402626006562	active site
402626006563	dimerization interface [polypeptide binding]; other site
402626006564	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
402626006565	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
402626006566	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
402626006567	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
402626006568	trimer interface [polypeptide binding]; other site
402626006569	active site
402626006570	substrate binding site [chemical binding]; other site
402626006571	CoA binding site [chemical binding]; other site
402626006572	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
402626006573	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
402626006574	putative active site [active]
402626006575	putative metal binding site [ion binding]; other site
402626006576	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
402626006577	substrate binding site [chemical binding]; other site
402626006578	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
402626006579	substrate binding site [chemical binding]; other site
402626006580	TPR repeat; Region: TPR_11; pfam13414
402626006581	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
402626006582	binding surface
402626006583	TPR motif; other site
402626006584	TPR repeat; Region: TPR_11; pfam13414
402626006585	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
402626006586	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
402626006587	active site
402626006588	HIGH motif; other site
402626006589	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
402626006590	KMSKS motif; other site
402626006591	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
402626006592	tRNA binding surface [nucleotide binding]; other site
402626006593	anticodon binding site; other site
402626006594	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
402626006595	endonuclease III; Region: ENDO3c; smart00478
402626006596	minor groove reading motif; other site
402626006597	helix-hairpin-helix signature motif; other site
402626006598	substrate binding pocket [chemical binding]; other site
402626006599	active site
402626006600	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
402626006601	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
402626006602	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
402626006603	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
402626006604	Ligand Binding Site [chemical binding]; other site
402626006605	TilS substrate binding domain; Region: TilS; pfam09179
402626006606	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
402626006607	aspartate kinase; Reviewed; Region: PRK06635
402626006608	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
402626006609	putative nucleotide binding site [chemical binding]; other site
402626006610	putative catalytic residues [active]
402626006611	putative Mg ion binding site [ion binding]; other site
402626006612	putative aspartate binding site [chemical binding]; other site
402626006613	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
402626006614	putative allosteric regulatory site; other site
402626006615	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
402626006616	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
402626006617	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
402626006618	NAD binding site [chemical binding]; other site
402626006619	homotetramer interface [polypeptide binding]; other site
402626006620	homodimer interface [polypeptide binding]; other site
402626006621	substrate binding site [chemical binding]; other site
402626006622	active site
402626006623	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
402626006624	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
402626006625	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
402626006626	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626006627	dimer interface [polypeptide binding]; other site
402626006628	conserved gate region; other site
402626006629	putative PBP binding loops; other site
402626006630	ABC-ATPase subunit interface; other site
402626006631	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
402626006632	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626006633	dimer interface [polypeptide binding]; other site
402626006634	conserved gate region; other site
402626006635	putative PBP binding loops; other site
402626006636	ABC-ATPase subunit interface; other site
402626006637	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
402626006638	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
402626006639	Walker A/P-loop; other site
402626006640	ATP binding site [chemical binding]; other site
402626006641	Q-loop/lid; other site
402626006642	ABC transporter signature motif; other site
402626006643	Walker B; other site
402626006644	D-loop; other site
402626006645	H-loop/switch region; other site
402626006646	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
402626006647	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
402626006648	Walker A/P-loop; other site
402626006649	ATP binding site [chemical binding]; other site
402626006650	Q-loop/lid; other site
402626006651	ABC transporter signature motif; other site
402626006652	Walker B; other site
402626006653	D-loop; other site
402626006654	H-loop/switch region; other site
402626006655	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
402626006656	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
402626006657	NlpC/P60 family; Region: NLPC_P60; pfam00877
402626006658	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
402626006659	Homeodomain-like domain; Region: HTH_23; cl17451
402626006660	putative transposase OrfB; Reviewed; Region: PHA02517
402626006661	Integrase core domain; Region: rve; pfam00665
402626006662	Integrase core domain; Region: rve_3; pfam13683
402626006663	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
402626006664	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
402626006665	nucleophile elbow; other site
402626006666	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
402626006667	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
402626006668	active site
402626006669	HIGH motif; other site
402626006670	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
402626006671	active site
402626006672	KMSKS motif; other site
402626006673	multidrug efflux protein; Reviewed; Region: PRK01766
402626006674	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
402626006675	cation binding site [ion binding]; other site
402626006676	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
402626006677	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
402626006678	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
402626006679	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
402626006680	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626006681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626006682	active site
402626006683	phosphorylation site [posttranslational modification]
402626006684	intermolecular recognition site; other site
402626006685	dimerization interface [polypeptide binding]; other site
402626006686	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626006687	DNA binding residues [nucleotide binding]
402626006688	dimerization interface [polypeptide binding]; other site
402626006689	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
402626006690	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626006691	Walker A motif; other site
402626006692	ATP binding site [chemical binding]; other site
402626006693	Walker B motif; other site
402626006694	arginine finger; other site
402626006695	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
402626006696	transcription termination factor Rho; Provisional; Region: rho; PRK09376
402626006697	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
402626006698	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
402626006699	RNA binding site [nucleotide binding]; other site
402626006700	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
402626006701	multimer interface [polypeptide binding]; other site
402626006702	Walker A motif; other site
402626006703	ATP binding site [chemical binding]; other site
402626006704	Walker B motif; other site
402626006705	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
402626006706	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
402626006707	catalytic residues [active]
402626006708	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
402626006709	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
402626006710	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
402626006711	Family description; Region: UvrD_C_2; pfam13538
402626006712	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
402626006713	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
402626006714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626006715	Walker A motif; other site
402626006716	ATP binding site [chemical binding]; other site
402626006717	Walker B motif; other site
402626006718	DNA polymerase III subunit delta'; Validated; Region: PRK08485
402626006719	arginine finger; other site
402626006720	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
402626006721	hypothetical protein; Validated; Region: PRK00153
402626006722	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
402626006723	recombination protein RecR; Reviewed; Region: recR; PRK00076
402626006724	RecR protein; Region: RecR; pfam02132
402626006725	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
402626006726	putative active site [active]
402626006727	putative metal-binding site [ion binding]; other site
402626006728	tetramer interface [polypeptide binding]; other site
402626006729	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
402626006730	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626006731	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626006732	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
402626006733	putative dimerization interface [polypeptide binding]; other site
402626006734	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
402626006735	CoA-transferase family III; Region: CoA_transf_3; pfam02515
402626006736	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
402626006737	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626006738	membrane-bound complex binding site; other site
402626006739	hinge residues; other site
402626006740	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
402626006741	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
402626006742	Walker A/P-loop; other site
402626006743	ATP binding site [chemical binding]; other site
402626006744	Q-loop/lid; other site
402626006745	ABC transporter signature motif; other site
402626006746	Walker B; other site
402626006747	D-loop; other site
402626006748	H-loop/switch region; other site
402626006749	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
402626006750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626006751	dimer interface [polypeptide binding]; other site
402626006752	conserved gate region; other site
402626006753	putative PBP binding loops; other site
402626006754	ABC-ATPase subunit interface; other site
402626006755	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626006756	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626006757	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
402626006758	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
402626006759	FMN binding site [chemical binding]; other site
402626006760	active site
402626006761	substrate binding site [chemical binding]; other site
402626006762	catalytic residue [active]
402626006763	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
402626006764	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
402626006765	NAD(P) binding site [chemical binding]; other site
402626006766	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
402626006767	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
402626006768	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626006769	S-adenosylmethionine binding site [chemical binding]; other site
402626006770	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
402626006771	Peptidase family M23; Region: Peptidase_M23; pfam01551
402626006772	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
402626006773	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
402626006774	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
402626006775	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
402626006776	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
402626006777	DNA binding residues [nucleotide binding]
402626006778	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
402626006779	putative catalytic site [active]
402626006780	putative metal binding site [ion binding]; other site
402626006781	putative phosphate binding site [ion binding]; other site
402626006782	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
402626006783	TRAM domain; Region: TRAM; cl01282
402626006784	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
402626006785	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626006786	S-adenosylmethionine binding site [chemical binding]; other site
402626006787	YccA-like proteins; Region: YccA_like; cd10433
402626006788	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
402626006789	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
402626006790	active site
402626006791	multimer interface [polypeptide binding]; other site
402626006792	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
402626006793	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626006794	FeS/SAM binding site; other site
402626006795	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
402626006796	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
402626006797	binding surface
402626006798	TPR motif; other site
402626006799	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
402626006800	binding surface
402626006801	TPR motif; other site
402626006802	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
402626006803	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
402626006804	non-specific DNA binding site [nucleotide binding]; other site
402626006805	salt bridge; other site
402626006806	sequence-specific DNA binding site [nucleotide binding]; other site
402626006807	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
402626006808	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
402626006809	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
402626006810	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
402626006811	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
402626006812	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
402626006813	dimer interface [polypeptide binding]; other site
402626006814	motif 1; other site
402626006815	active site
402626006816	motif 2; other site
402626006817	motif 3; other site
402626006818	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
402626006819	anticodon binding site; other site
402626006820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
402626006821	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
402626006822	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
402626006823	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
402626006824	Trp docking motif [polypeptide binding]; other site
402626006825	active site
402626006826	GTP-binding protein Der; Reviewed; Region: PRK00093
402626006827	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
402626006828	G1 box; other site
402626006829	GTP/Mg2+ binding site [chemical binding]; other site
402626006830	Switch I region; other site
402626006831	G2 box; other site
402626006832	Switch II region; other site
402626006833	G3 box; other site
402626006834	G4 box; other site
402626006835	G5 box; other site
402626006836	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
402626006837	G1 box; other site
402626006838	GTP/Mg2+ binding site [chemical binding]; other site
402626006839	Switch I region; other site
402626006840	G2 box; other site
402626006841	G3 box; other site
402626006842	Switch II region; other site
402626006843	G4 box; other site
402626006844	G5 box; other site
402626006845	bacterial Hfq-like; Region: Hfq; cd01716
402626006846	hexamer interface [polypeptide binding]; other site
402626006847	Sm1 motif; other site
402626006848	RNA binding site [nucleotide binding]; other site
402626006849	Sm2 motif; other site
402626006850	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
402626006851	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
402626006852	HflX GTPase family; Region: HflX; cd01878
402626006853	G1 box; other site
402626006854	GTP/Mg2+ binding site [chemical binding]; other site
402626006855	Switch I region; other site
402626006856	G2 box; other site
402626006857	G3 box; other site
402626006858	Switch II region; other site
402626006859	G4 box; other site
402626006860	G5 box; other site
402626006861	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
402626006862	HflK protein; Region: hflK; TIGR01933
402626006863	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
402626006864	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
402626006865	HflC protein; Region: hflC; TIGR01932
402626006866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
402626006867	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
402626006868	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
402626006869	dimer interface [polypeptide binding]; other site
402626006870	motif 1; other site
402626006871	active site
402626006872	motif 2; other site
402626006873	motif 3; other site
402626006874	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
402626006875	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
402626006876	GDP-binding site [chemical binding]; other site
402626006877	ACT binding site; other site
402626006878	IMP binding site; other site
402626006879	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
402626006880	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
402626006881	active site
402626006882	ribonuclease R; Region: RNase_R; TIGR02063
402626006883	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
402626006884	RNB domain; Region: RNB; pfam00773
402626006885	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
402626006886	RNA binding site [nucleotide binding]; other site
402626006887	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
402626006888	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
402626006889	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
402626006890	NAD-dependent deacetylase; Provisional; Region: PRK00481
402626006891	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
402626006892	NAD+ binding site [chemical binding]; other site
402626006893	substrate binding site [chemical binding]; other site
402626006894	Zn binding site [ion binding]; other site
402626006895	transaldolase-like protein; Provisional; Region: PTZ00411
402626006896	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
402626006897	active site
402626006898	dimer interface [polypeptide binding]; other site
402626006899	catalytic residue [active]
402626006900	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
402626006901	tetramer (dimer of dimers) interface [polypeptide binding]; other site
402626006902	active site
402626006903	dimer interface [polypeptide binding]; other site
402626006904	oxidative damage protection protein; Provisional; Region: PRK05408
402626006905	N-acetylglutamate synthase; Validated; Region: PRK05279
402626006906	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
402626006907	putative feedback inhibition sensing region; other site
402626006908	putative nucleotide binding site [chemical binding]; other site
402626006909	putative substrate binding site [chemical binding]; other site
402626006910	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626006911	Coenzyme A binding pocket [chemical binding]; other site
402626006912	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
402626006913	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
402626006914	ATP binding site [chemical binding]; other site
402626006915	putative Mg++ binding site [ion binding]; other site
402626006916	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
402626006917	nucleotide binding region [chemical binding]; other site
402626006918	ATP-binding site [chemical binding]; other site
402626006919	Helicase associated domain (HA2); Region: HA2; pfam04408
402626006920	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
402626006921	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
402626006922	Uncharacterized conserved protein [Function unknown]; Region: COG3391
402626006923	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
402626006924	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
402626006925	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
402626006926	NodB motif; other site
402626006927	active site
402626006928	catalytic site [active]
402626006929	metal binding site [ion binding]; metal-binding site
402626006930	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
402626006931	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
402626006932	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
402626006933	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
402626006934	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
402626006935	putative MPT binding site; other site
402626006936	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
402626006937	active site residue [active]
402626006938	glutamine synthetase; Provisional; Region: glnA; PRK09469
402626006939	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
402626006940	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
402626006941	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
402626006942	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
402626006943	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626006944	dimer interface [polypeptide binding]; other site
402626006945	phosphorylation site [posttranslational modification]
402626006946	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626006947	ATP binding site [chemical binding]; other site
402626006948	Mg2+ binding site [ion binding]; other site
402626006949	G-X-G motif; other site
402626006950	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
402626006951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626006952	active site
402626006953	phosphorylation site [posttranslational modification]
402626006954	intermolecular recognition site; other site
402626006955	dimerization interface [polypeptide binding]; other site
402626006956	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626006957	Walker A motif; other site
402626006958	ATP binding site [chemical binding]; other site
402626006959	Walker B motif; other site
402626006960	arginine finger; other site
402626006961	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626006962	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
402626006963	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626006964	active site
402626006965	motif I; other site
402626006966	motif II; other site
402626006967	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
402626006968	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
402626006969	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
402626006970	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626006971	dimer interface [polypeptide binding]; other site
402626006972	conserved gate region; other site
402626006973	putative PBP binding loops; other site
402626006974	ABC-ATPase subunit interface; other site
402626006975	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
402626006976	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626006977	dimer interface [polypeptide binding]; other site
402626006978	conserved gate region; other site
402626006979	putative PBP binding loops; other site
402626006980	ABC-ATPase subunit interface; other site
402626006981	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
402626006982	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
402626006983	Walker A/P-loop; other site
402626006984	ATP binding site [chemical binding]; other site
402626006985	Q-loop/lid; other site
402626006986	ABC transporter signature motif; other site
402626006987	Walker B; other site
402626006988	D-loop; other site
402626006989	H-loop/switch region; other site
402626006990	TOBE domain; Region: TOBE_2; pfam08402
402626006991	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
402626006992	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
402626006993	putative active site [active]
402626006994	catalytic site [active]
402626006995	putative metal binding site [ion binding]; other site
402626006996	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
402626006997	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
402626006998	TPP-binding site [chemical binding]; other site
402626006999	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
402626007000	dimer interface [polypeptide binding]; other site
402626007001	PYR/PP interface [polypeptide binding]; other site
402626007002	TPP binding site [chemical binding]; other site
402626007003	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
402626007004	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
402626007005	E3 interaction surface; other site
402626007006	lipoyl attachment site [posttranslational modification]; other site
402626007007	e3 binding domain; Region: E3_binding; pfam02817
402626007008	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
402626007009	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
402626007010	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
402626007011	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
402626007012	Predicted ATPase [General function prediction only]; Region: COG1485
402626007013	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626007014	Walker B; other site
402626007015	D-loop; other site
402626007016	H-loop/switch region; other site
402626007017	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
402626007018	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
402626007019	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
402626007020	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
402626007021	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
402626007022	metal-binding site [ion binding]
402626007023	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626007024	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626007025	motif II; other site
402626007026	Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197
402626007027	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
402626007028	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
402626007029	Low-spin heme binding site [chemical binding]; other site
402626007030	Putative water exit pathway; other site
402626007031	Binuclear center (active site) [active]
402626007032	Putative proton exit pathway; other site
402626007033	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
402626007034	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
402626007035	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282
402626007036	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
402626007037	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
402626007038	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
402626007039	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
402626007040	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
402626007041	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
402626007042	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
402626007043	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
402626007044	ligand binding site [chemical binding]; other site
402626007045	flexible hinge region; other site
402626007046	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
402626007047	putative switch regulator; other site
402626007048	non-specific DNA interactions [nucleotide binding]; other site
402626007049	DNA binding site [nucleotide binding]
402626007050	sequence specific DNA binding site [nucleotide binding]; other site
402626007051	putative cAMP binding site [chemical binding]; other site
402626007052	Uncharacterized conserved protein [Function unknown]; Region: COG2836
402626007053	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
402626007054	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
402626007055	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
402626007056	RNA binding surface [nucleotide binding]; other site
402626007057	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
402626007058	probable active site [active]
402626007059	ribosome maturation protein RimP; Reviewed; Region: PRK00092
402626007060	Sm and related proteins; Region: Sm_like; cl00259
402626007061	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
402626007062	putative oligomer interface [polypeptide binding]; other site
402626007063	putative RNA binding site [nucleotide binding]; other site
402626007064	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
402626007065	NusA N-terminal domain; Region: NusA_N; pfam08529
402626007066	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
402626007067	RNA binding site [nucleotide binding]; other site
402626007068	homodimer interface [polypeptide binding]; other site
402626007069	NusA-like KH domain; Region: KH_5; pfam13184
402626007070	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
402626007071	G-X-X-G motif; other site
402626007072	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
402626007073	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
402626007074	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
402626007075	translation initiation factor IF-2; Region: IF-2; TIGR00487
402626007076	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
402626007077	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
402626007078	G1 box; other site
402626007079	putative GEF interaction site [polypeptide binding]; other site
402626007080	GTP/Mg2+ binding site [chemical binding]; other site
402626007081	Switch I region; other site
402626007082	G2 box; other site
402626007083	G3 box; other site
402626007084	Switch II region; other site
402626007085	G4 box; other site
402626007086	G5 box; other site
402626007087	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
402626007088	Translation-initiation factor 2; Region: IF-2; pfam11987
402626007089	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
402626007090	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
402626007091	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
402626007092	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
402626007093	RNA binding site [nucleotide binding]; other site
402626007094	active site
402626007095	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
402626007096	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
402626007097	Homeodomain-like domain; Region: HTH_23; cl17451
402626007098	putative transposase OrfB; Reviewed; Region: PHA02517
402626007099	Integrase core domain; Region: rve; pfam00665
402626007100	Integrase core domain; Region: rve_3; pfam13683
402626007101	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
402626007102	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626007103	putative substrate translocation pore; other site
402626007104	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
402626007105	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626007106	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
402626007107	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
402626007108	MarR family; Region: MarR; pfam01047
402626007109	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
402626007110	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
402626007111	G1 box; other site
402626007112	putative GEF interaction site [polypeptide binding]; other site
402626007113	GTP/Mg2+ binding site [chemical binding]; other site
402626007114	Switch I region; other site
402626007115	G2 box; other site
402626007116	G3 box; other site
402626007117	Switch II region; other site
402626007118	G4 box; other site
402626007119	G5 box; other site
402626007120	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
402626007121	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
402626007122	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
402626007123	active site residue [active]
402626007124	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
402626007125	active site residue [active]
402626007126	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
402626007127	active site residue [active]
402626007128	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
402626007129	active site residue [active]
402626007130	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626007131	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626007132	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
402626007133	putative dimerization interface [polypeptide binding]; other site
402626007134	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
402626007135	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
402626007136	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
402626007137	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626007138	substrate binding site [chemical binding]; other site
402626007139	oxyanion hole (OAH) forming residues; other site
402626007140	trimer interface [polypeptide binding]; other site
402626007141	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
402626007142	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
402626007143	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
402626007144	classical (c) SDRs; Region: SDR_c; cd05233
402626007145	NAD(P) binding site [chemical binding]; other site
402626007146	active site
402626007147	glutathionine S-transferase; Provisional; Region: PRK10542
402626007148	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
402626007149	C-terminal domain interface [polypeptide binding]; other site
402626007150	GSH binding site (G-site) [chemical binding]; other site
402626007151	dimer interface [polypeptide binding]; other site
402626007152	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
402626007153	dimer interface [polypeptide binding]; other site
402626007154	N-terminal domain interface [polypeptide binding]; other site
402626007155	substrate binding pocket (H-site) [chemical binding]; other site
402626007156	Transposase; Region: HTH_Tnp_1; cl17663
402626007157	HTH-like domain; Region: HTH_21; pfam13276
402626007158	Integrase core domain; Region: rve; pfam00665
402626007159	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
402626007160	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
402626007161	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
402626007162	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
402626007163	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
402626007164	substrate-cofactor binding pocket; other site
402626007165	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626007166	catalytic residue [active]
402626007167	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187
402626007168	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
402626007169	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
402626007170	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
402626007171	active site
402626007172	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
402626007173	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
402626007174	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626007175	Enoylreductase; Region: PKS_ER; smart00829
402626007176	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
402626007177	NAD(P) binding site [chemical binding]; other site
402626007178	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
402626007179	KR domain; Region: KR; pfam08659
402626007180	putative NADP binding site [chemical binding]; other site
402626007181	active site
402626007182	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
402626007183	Sulfatase; Region: Sulfatase; cl17466
402626007184	short chain dehydrogenase; Provisional; Region: PRK07023
402626007185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626007186	NAD(P) binding site [chemical binding]; other site
402626007187	active site
402626007188	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
402626007189	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
402626007190	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
402626007191	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
402626007192	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
402626007193	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
402626007194	Walker A/P-loop; other site
402626007195	ATP binding site [chemical binding]; other site
402626007196	Q-loop/lid; other site
402626007197	ABC transporter signature motif; other site
402626007198	Walker B; other site
402626007199	D-loop; other site
402626007200	H-loop/switch region; other site
402626007201	Helix-turn-helix domain; Region: HTH_28; pfam13518
402626007202	Winged helix-turn helix; Region: HTH_29; pfam13551
402626007203	Winged helix-turn helix; Region: HTH_33; pfam13592
402626007204	DDE superfamily endonuclease; Region: DDE_3; pfam13358
402626007205	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
402626007206	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
402626007207	trimer interface [polypeptide binding]; other site
402626007208	active site
402626007209	substrate binding site [chemical binding]; other site
402626007210	CoA binding site [chemical binding]; other site
402626007211	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
402626007212	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
402626007213	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
402626007214	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
402626007215	NADP-binding site; other site
402626007216	homotetramer interface [polypeptide binding]; other site
402626007217	substrate binding site [chemical binding]; other site
402626007218	homodimer interface [polypeptide binding]; other site
402626007219	active site
402626007220	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
402626007221	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
402626007222	NADP-binding site; other site
402626007223	homotetramer interface [polypeptide binding]; other site
402626007224	substrate binding site [chemical binding]; other site
402626007225	homodimer interface [polypeptide binding]; other site
402626007226	active site
402626007227	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
402626007228	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
402626007229	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
402626007230	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
402626007231	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
402626007232	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
402626007233	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
402626007234	PspA/IM30 family; Region: PspA_IM30; pfam04012
402626007235	Protein of unknown function (DUF3585); Region: DUF3585; pfam12130
402626007236	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
402626007237	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
402626007238	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
402626007239	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
402626007240	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
402626007241	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
402626007242	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
402626007243	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
402626007244	Substrate binding site; other site
402626007245	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
402626007246	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626007247	NAD(P) binding site [chemical binding]; other site
402626007248	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
402626007249	active site
402626007250	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
402626007251	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626007252	active site
402626007253	Transposase; Region: HTH_Tnp_1; cl17663
402626007254	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
402626007255	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
402626007256	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
402626007257	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
402626007258	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
402626007259	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
402626007260	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
402626007261	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626007262	PAS domain; Region: PAS_9; pfam13426
402626007263	putative active site [active]
402626007264	heme pocket [chemical binding]; other site
402626007265	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626007266	PAS domain; Region: PAS_9; pfam13426
402626007267	putative active site [active]
402626007268	heme pocket [chemical binding]; other site
402626007269	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626007270	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626007271	metal binding site [ion binding]; metal-binding site
402626007272	active site
402626007273	I-site; other site
402626007274	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626007275	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
402626007276	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
402626007277	FMN binding site [chemical binding]; other site
402626007278	active site
402626007279	catalytic residues [active]
402626007280	substrate binding site [chemical binding]; other site
402626007281	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
402626007282	hypothetical protein; Provisional; Region: PRK06156
402626007283	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
402626007284	active site
402626007285	metal binding site [ion binding]; metal-binding site
402626007286	Cupin domain; Region: Cupin_2; cl17218
402626007287	LexA repressor; Validated; Region: PRK00215
402626007288	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
402626007289	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
402626007290	Catalytic site [active]
402626007291	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
402626007292	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
402626007293	FAD binding pocket [chemical binding]; other site
402626007294	FAD binding motif [chemical binding]; other site
402626007295	phosphate binding motif [ion binding]; other site
402626007296	beta-alpha-beta structure motif; other site
402626007297	NAD binding pocket [chemical binding]; other site
402626007298	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
402626007299	active site
402626007300	homodimer interface [polypeptide binding]; other site
402626007301	homotetramer interface [polypeptide binding]; other site
402626007302	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
402626007303	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
402626007304	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
402626007305	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
402626007306	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
402626007307	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
402626007308	replicative DNA helicase; Provisional; Region: PRK07004
402626007309	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
402626007310	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
402626007311	Walker A motif; other site
402626007312	ATP binding site [chemical binding]; other site
402626007313	Walker B motif; other site
402626007314	DNA binding loops [nucleotide binding]
402626007315	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
402626007316	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
402626007317	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
402626007318	NlpC/P60 family; Region: NLPC_P60; pfam00877
402626007319	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
402626007320	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
402626007321	putative active site [active]
402626007322	PhoH-like protein; Region: PhoH; pfam02562
402626007323	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
402626007324	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
402626007325	catalytic triad [active]
402626007326	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
402626007327	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
402626007328	putative active site [active]
402626007329	putative catalytic site [active]
402626007330	putative Zn binding site [ion binding]; other site
402626007331	NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908
402626007332	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
402626007333	NAD binding site [chemical binding]; other site
402626007334	substrate binding site [chemical binding]; other site
402626007335	active site
402626007336	putative formyltransferase; Provisional; Region: PRK06988
402626007337	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
402626007338	active site
402626007339	substrate binding site [chemical binding]; other site
402626007340	cosubstrate binding site; other site
402626007341	catalytic site [active]
402626007342	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
402626007343	active site
402626007344	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
402626007345	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
402626007346	Ligand binding site; other site
402626007347	Putative Catalytic site; other site
402626007348	DXD motif; other site
402626007349	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
402626007350	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
402626007351	inhibitor-cofactor binding pocket; inhibition site
402626007352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626007353	catalytic residue [active]
402626007354	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
402626007355	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
402626007356	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
402626007357	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
402626007358	aminotransferase AlaT; Validated; Region: PRK09265
402626007359	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626007360	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626007361	homodimer interface [polypeptide binding]; other site
402626007362	catalytic residue [active]
402626007363	homoserine dehydrogenase; Provisional; Region: PRK06349
402626007364	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
402626007365	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
402626007366	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
402626007367	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
402626007368	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
402626007369	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626007370	catalytic residue [active]
402626007371	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
402626007372	putative uracil binding site [chemical binding]; other site
402626007373	putative active site [active]
402626007374	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
402626007375	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
402626007376	dimer interface [polypeptide binding]; other site
402626007377	putative functional site; other site
402626007378	putative MPT binding site; other site
402626007379	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
402626007380	MoaE interaction surface [polypeptide binding]; other site
402626007381	MoeB interaction surface [polypeptide binding]; other site
402626007382	thiocarboxylated glycine; other site
402626007383	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
402626007384	MoaE homodimer interface [polypeptide binding]; other site
402626007385	MoaD interaction [polypeptide binding]; other site
402626007386	active site residues [active]
402626007387	chromosome condensation membrane protein; Provisional; Region: PRK14196
402626007388	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
402626007389	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
402626007390	Clp amino terminal domain; Region: Clp_N; pfam02861
402626007391	Clp amino terminal domain; Region: Clp_N; pfam02861
402626007392	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626007393	Walker A motif; other site
402626007394	ATP binding site [chemical binding]; other site
402626007395	Walker B motif; other site
402626007396	arginine finger; other site
402626007397	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626007398	Walker A motif; other site
402626007399	ATP binding site [chemical binding]; other site
402626007400	Walker B motif; other site
402626007401	arginine finger; other site
402626007402	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
402626007403	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
402626007404	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
402626007405	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
402626007406	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
402626007407	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
402626007408	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626007409	substrate binding pocket [chemical binding]; other site
402626007410	membrane-bound complex binding site; other site
402626007411	hinge residues; other site
402626007412	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
402626007413	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626007414	substrate binding pocket [chemical binding]; other site
402626007415	membrane-bound complex binding site; other site
402626007416	hinge residues; other site
402626007417	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
402626007418	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
402626007419	active site
402626007420	dimer interface [polypeptide binding]; other site
402626007421	non-prolyl cis peptide bond; other site
402626007422	insertion regions; other site
402626007423	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
402626007424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626007425	putative PBP binding loops; other site
402626007426	ABC-ATPase subunit interface; other site
402626007427	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
402626007428	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
402626007429	Walker A/P-loop; other site
402626007430	ATP binding site [chemical binding]; other site
402626007431	Q-loop/lid; other site
402626007432	ABC transporter signature motif; other site
402626007433	Walker B; other site
402626007434	D-loop; other site
402626007435	H-loop/switch region; other site
402626007436	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
402626007437	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626007438	Serine hydrolase; Region: Ser_hydrolase; pfam06821
402626007439	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
402626007440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626007441	dimer interface [polypeptide binding]; other site
402626007442	conserved gate region; other site
402626007443	putative PBP binding loops; other site
402626007444	ABC-ATPase subunit interface; other site
402626007445	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626007446	dimer interface [polypeptide binding]; other site
402626007447	conserved gate region; other site
402626007448	putative PBP binding loops; other site
402626007449	ABC-ATPase subunit interface; other site
402626007450	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
402626007451	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
402626007452	Walker A/P-loop; other site
402626007453	ATP binding site [chemical binding]; other site
402626007454	Q-loop/lid; other site
402626007455	ABC transporter signature motif; other site
402626007456	Walker B; other site
402626007457	D-loop; other site
402626007458	H-loop/switch region; other site
402626007459	TOBE-like domain; Region: TOBE_3; pfam12857
402626007460	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
402626007461	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626007462	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
402626007463	substrate binding site [chemical binding]; other site
402626007464	dimerization interface [polypeptide binding]; other site
402626007465	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
402626007466	Histidine kinase; Region: His_kinase; pfam06580
402626007467	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626007468	ATP binding site [chemical binding]; other site
402626007469	Mg2+ binding site [ion binding]; other site
402626007470	G-X-G motif; other site
402626007471	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
402626007472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626007473	active site
402626007474	phosphorylation site [posttranslational modification]
402626007475	intermolecular recognition site; other site
402626007476	dimerization interface [polypeptide binding]; other site
402626007477	LytTr DNA-binding domain; Region: LytTR; smart00850
402626007478	thiamine pyrophosphate protein; Validated; Region: PRK08199
402626007479	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
402626007480	PYR/PP interface [polypeptide binding]; other site
402626007481	dimer interface [polypeptide binding]; other site
402626007482	TPP binding site [chemical binding]; other site
402626007483	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
402626007484	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
402626007485	TPP-binding site [chemical binding]; other site
402626007486	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
402626007487	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
402626007488	putative active site pocket [active]
402626007489	dimerization interface [polypeptide binding]; other site
402626007490	putative catalytic residue [active]
402626007491	putative L-aspartate dehydrogenase; Provisional; Region: PRK13302
402626007492	isocitrate lyase; Provisional; Region: PRK15063
402626007493	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
402626007494	tetramer interface [polypeptide binding]; other site
402626007495	active site
402626007496	Mg2+/Mn2+ binding site [ion binding]; other site
402626007497	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
402626007498	Ligand Binding Site [chemical binding]; other site
402626007499	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626007500	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626007501	putative effector binding pocket; other site
402626007502	dimerization interface [polypeptide binding]; other site
402626007503	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
402626007504	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626007505	motif II; other site
402626007506	malate synthase A; Region: malate_syn_A; TIGR01344
402626007507	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
402626007508	active site
402626007509	DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863
402626007510	putative hydrophobic ligand binding site [chemical binding]; other site
402626007511	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
402626007512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626007513	putative substrate translocation pore; other site
402626007514	Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
402626007515	acyl-CoA binding pocket [chemical binding]; other site
402626007516	CoA binding site [chemical binding]; other site
402626007517	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
402626007518	Glycoprotease family; Region: Peptidase_M22; pfam00814
402626007519	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
402626007520	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
402626007521	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
402626007522	Fe-S cluster binding site [ion binding]; other site
402626007523	active site
402626007524	lysophospholipid transporter LplT; Provisional; Region: PRK11195
402626007525	alanine racemase; Reviewed; Region: alr; PRK00053
402626007526	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
402626007527	active site
402626007528	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
402626007529	substrate binding site [chemical binding]; other site
402626007530	catalytic residues [active]
402626007531	dimer interface [polypeptide binding]; other site
402626007532	DNA repair protein RadA; Provisional; Region: PRK11823
402626007533	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
402626007534	Walker A motif/ATP binding site; other site
402626007535	ATP binding site [chemical binding]; other site
402626007536	Walker B motif; other site
402626007537	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
402626007538	disulfide bond formation protein B; Provisional; Region: PRK02110
402626007539	Protein of unknown function (DUF523); Region: DUF523; cl00733
402626007540	formyl-CoA transferase; Region: oxalate_frc; TIGR03253
402626007541	CoA-transferase family III; Region: CoA_transf_3; pfam02515
402626007542	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
402626007543	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
402626007544	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
402626007545	ABC transporter; Region: ABC_tran_2; pfam12848
402626007546	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
402626007547	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
402626007548	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
402626007549	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
402626007550	putative active site [active]
402626007551	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
402626007552	catalytic nucleophile [active]
402626007553	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
402626007554	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
402626007555	Walker A/P-loop; other site
402626007556	ATP binding site [chemical binding]; other site
402626007557	Q-loop/lid; other site
402626007558	ABC transporter signature motif; other site
402626007559	Walker B; other site
402626007560	D-loop; other site
402626007561	H-loop/switch region; other site
402626007562	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
402626007563	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
402626007564	Walker A/P-loop; other site
402626007565	ATP binding site [chemical binding]; other site
402626007566	Q-loop/lid; other site
402626007567	ABC transporter signature motif; other site
402626007568	Walker B; other site
402626007569	D-loop; other site
402626007570	H-loop/switch region; other site
402626007571	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
402626007572	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
402626007573	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
402626007574	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
402626007575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626007576	dimer interface [polypeptide binding]; other site
402626007577	conserved gate region; other site
402626007578	putative PBP binding loops; other site
402626007579	ABC-ATPase subunit interface; other site
402626007580	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
402626007581	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
402626007582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626007583	dimer interface [polypeptide binding]; other site
402626007584	conserved gate region; other site
402626007585	putative PBP binding loops; other site
402626007586	ABC-ATPase subunit interface; other site
402626007587	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
402626007588	homodimer interface [polypeptide binding]; other site
402626007589	homotetramer interface [polypeptide binding]; other site
402626007590	active site pocket [active]
402626007591	cleavage site
402626007592	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
402626007593	SxDxEG motif; other site
402626007594	active site
402626007595	metal binding site [ion binding]; metal-binding site
402626007596	homopentamer interface [polypeptide binding]; other site
402626007597	Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486
402626007598	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
402626007599	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
402626007600	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
402626007601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626007602	S-adenosylmethionine binding site [chemical binding]; other site
402626007603	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
402626007604	putative active site [active]
402626007605	putative metal binding residues [ion binding]; other site
402626007606	signature motif; other site
402626007607	putative triphosphate binding site [ion binding]; other site
402626007608	dimer interface [polypeptide binding]; other site
402626007609	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
402626007610	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
402626007611	metal binding site [ion binding]; metal-binding site
402626007612	dimer interface [polypeptide binding]; other site
402626007613	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
402626007614	ArsC family; Region: ArsC; pfam03960
402626007615	putative catalytic residues [active]
402626007616	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
402626007617	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
402626007618	trimer interface [polypeptide binding]; other site
402626007619	active site
402626007620	substrate binding site [chemical binding]; other site
402626007621	CoA binding site [chemical binding]; other site
402626007622	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
402626007623	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626007624	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626007625	homodimer interface [polypeptide binding]; other site
402626007626	catalytic residue [active]
402626007627	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
402626007628	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
402626007629	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
402626007630	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
402626007631	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
402626007632	Walker A/P-loop; other site
402626007633	ATP binding site [chemical binding]; other site
402626007634	Q-loop/lid; other site
402626007635	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
402626007636	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
402626007637	ABC transporter signature motif; other site
402626007638	Walker B; other site
402626007639	D-loop; other site
402626007640	H-loop/switch region; other site
402626007641	ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771
402626007642	Ligase N family; Region: LIGANc; smart00532
402626007643	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
402626007644	nucleotide binding pocket [chemical binding]; other site
402626007645	K-X-D-G motif; other site
402626007646	catalytic site [active]
402626007647	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
402626007648	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
402626007649	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
402626007650	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
402626007651	Dimer interface [polypeptide binding]; other site
402626007652	BRCT sequence motif; other site
402626007653	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
402626007654	active site
402626007655	catalytic residues [active]
402626007656	metal binding site [ion binding]; metal-binding site
402626007657	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
402626007658	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
402626007659	RNA binding surface [nucleotide binding]; other site
402626007660	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
402626007661	active site
402626007662	PII uridylyl-transferase; Provisional; Region: PRK03059
402626007663	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
402626007664	metal binding triad; other site
402626007665	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
402626007666	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
402626007667	Zn2+ binding site [ion binding]; other site
402626007668	Mg2+ binding site [ion binding]; other site
402626007669	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
402626007670	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
402626007671	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
402626007672	active site
402626007673	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
402626007674	rRNA interaction site [nucleotide binding]; other site
402626007675	S8 interaction site; other site
402626007676	putative laminin-1 binding site; other site
402626007677	elongation factor Ts; Provisional; Region: tsf; PRK09377
402626007678	UBA/TS-N domain; Region: UBA; pfam00627
402626007679	Elongation factor TS; Region: EF_TS; pfam00889
402626007680	Elongation factor TS; Region: EF_TS; pfam00889
402626007681	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
402626007682	putative nucleotide binding site [chemical binding]; other site
402626007683	uridine monophosphate binding site [chemical binding]; other site
402626007684	homohexameric interface [polypeptide binding]; other site
402626007685	ribosome recycling factor; Reviewed; Region: frr; PRK00083
402626007686	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
402626007687	hinge region; other site
402626007688	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
402626007689	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
402626007690	catalytic residue [active]
402626007691	putative FPP diphosphate  binding site; other site
402626007692	putative FPP binding hydrophobic cleft; other site
402626007693	dimer interface [polypeptide binding]; other site
402626007694	putative IPP diphosphate binding site; other site
402626007695	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
402626007696	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
402626007697	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
402626007698	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
402626007699	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
402626007700	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
402626007701	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
402626007702	zinc metallopeptidase RseP; Provisional; Region: PRK10779
402626007703	active site
402626007704	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
402626007705	putative substrate binding region [chemical binding]; other site
402626007706	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
402626007707	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
402626007708	putative substrate binding region [chemical binding]; other site
402626007709	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
402626007710	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
402626007711	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
402626007712	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
402626007713	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
402626007714	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
402626007715	Surface antigen; Region: Bac_surface_Ag; pfam01103
402626007716	periplasmic chaperone; Provisional; Region: PRK10780
402626007717	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
402626007718	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
402626007719	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
402626007720	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
402626007721	trimer interface [polypeptide binding]; other site
402626007722	active site
402626007723	UDP-GlcNAc binding site [chemical binding]; other site
402626007724	lipid binding site [chemical binding]; lipid-binding site
402626007725	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
402626007726	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
402626007727	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
402626007728	active site
402626007729	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
402626007730	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
402626007731	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
402626007732	RNA/DNA hybrid binding site [nucleotide binding]; other site
402626007733	active site
402626007734	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
402626007735	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
402626007736	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
402626007737	active site
402626007738	short chain dehydrogenase; Validated; Region: PRK05855
402626007739	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
402626007740	classical (c) SDRs; Region: SDR_c; cd05233
402626007741	NAD(P) binding site [chemical binding]; other site
402626007742	active site
402626007743	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
402626007744	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
402626007745	PEP synthetase regulatory protein; Provisional; Region: PRK05339
402626007746	phosphoenolpyruvate synthase; Validated; Region: PRK06464
402626007747	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
402626007748	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
402626007749	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
402626007750	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
402626007751	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
402626007752	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
402626007753	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
402626007754	SmpB-tmRNA interface; other site
402626007755	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
402626007756	putative coenzyme Q binding site [chemical binding]; other site
402626007757	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
402626007758	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
402626007759	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
402626007760	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
402626007761	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
402626007762	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
402626007763	active site
402626007764	GMP synthase; Reviewed; Region: guaA; PRK00074
402626007765	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
402626007766	AMP/PPi binding site [chemical binding]; other site
402626007767	candidate oxyanion hole; other site
402626007768	catalytic triad [active]
402626007769	potential glutamine specificity residues [chemical binding]; other site
402626007770	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
402626007771	ATP Binding subdomain [chemical binding]; other site
402626007772	Ligand Binding sites [chemical binding]; other site
402626007773	Dimerization subdomain; other site
402626007774	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
402626007775	DNA-binding site [nucleotide binding]; DNA binding site
402626007776	RNA-binding motif; other site
402626007777	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
402626007778	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
402626007779	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
402626007780	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
402626007781	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
402626007782	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
402626007783	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626007784	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
402626007785	putative dimerization interface [polypeptide binding]; other site
402626007786	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
402626007787	heterodimer interface [polypeptide binding]; other site
402626007788	multimer interface [polypeptide binding]; other site
402626007789	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
402626007790	active site
402626007791	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
402626007792	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
402626007793	heterodimer interface [polypeptide binding]; other site
402626007794	active site
402626007795	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
402626007796	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
402626007797	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
402626007798	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
402626007799	catalytic residues [active]
402626007800	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
402626007801	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626007802	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626007803	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626007804	putative effector binding pocket; other site
402626007805	dimerization interface [polypeptide binding]; other site
402626007806	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626007807	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626007808	putative substrate translocation pore; other site
402626007809	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
402626007810	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
402626007811	tetramer interface [polypeptide binding]; other site
402626007812	active site
402626007813	Mg2+/Mn2+ binding site [ion binding]; other site
402626007814	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
402626007815	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
402626007816	putative catalytic residue [active]
402626007817	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
402626007818	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626007819	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
402626007820	dimerization interface [polypeptide binding]; other site
402626007821	substrate binding pocket [chemical binding]; other site
402626007822	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626007823	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
402626007824	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626007825	FeS/SAM binding site; other site
402626007826	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
402626007827	active site
402626007828	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
402626007829	nucleoside/Zn binding site; other site
402626007830	dimer interface [polypeptide binding]; other site
402626007831	catalytic motif [active]
402626007832	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
402626007833	dimer interface [polypeptide binding]; other site
402626007834	catalytic triad [active]
402626007835	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
402626007836	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
402626007837	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
402626007838	ABC transporter; Region: ABC_tran_2; pfam12848
402626007839	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
402626007840	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
402626007841	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
402626007842	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
402626007843	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626007844	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626007845	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
402626007846	putative dimerization interface [polypeptide binding]; other site
402626007847	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
402626007848	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
402626007849	NAD binding site [chemical binding]; other site
402626007850	catalytic residues [active]
402626007851	Predicted Fe-S protein [General function prediction only]; Region: COG3313
402626007852	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
402626007853	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
402626007854	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
402626007855	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
402626007856	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
402626007857	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
402626007858	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
402626007859	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
402626007860	MgtC family; Region: MgtC; pfam02308
402626007861	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
402626007862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626007863	NAD(P) binding site [chemical binding]; other site
402626007864	active site
402626007865	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
402626007866	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
402626007867	XdhC Rossmann domain; Region: XdhC_C; pfam13478
402626007868	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
402626007869	putative hydrophobic ligand binding site [chemical binding]; other site
402626007870	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
402626007871	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
402626007872	metal ion-dependent adhesion site (MIDAS); other site
402626007873	MoxR-like ATPases [General function prediction only]; Region: COG0714
402626007874	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626007875	Walker A motif; other site
402626007876	ATP binding site [chemical binding]; other site
402626007877	Walker B motif; other site
402626007878	arginine finger; other site
402626007879	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
402626007880	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
402626007881	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
402626007882	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
402626007883	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
402626007884	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
402626007885	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
402626007886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
402626007887	CreA protein; Region: CreA; pfam05981
402626007888	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626007889	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626007890	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626007891	putative effector binding pocket; other site
402626007892	dimerization interface [polypeptide binding]; other site
402626007893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626007894	putative substrate translocation pore; other site
402626007895	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
402626007896	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
402626007897	Transglycosylase; Region: Transgly; pfam00912
402626007898	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
402626007899	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626007900	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
402626007901	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
402626007902	dimerizarion interface [polypeptide binding]; other site
402626007903	CrgA pocket; other site
402626007904	substrate binding pocket [chemical binding]; other site
402626007905	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
402626007906	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
402626007907	octamer interface [polypeptide binding]; other site
402626007908	active site
402626007909	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
402626007910	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
402626007911	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
402626007912	dimer interface [polypeptide binding]; other site
402626007913	active site
402626007914	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
402626007915	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
402626007916	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
402626007917	putative alpha subunit interface [polypeptide binding]; other site
402626007918	putative active site [active]
402626007919	putative substrate binding site [chemical binding]; other site
402626007920	Fe binding site [ion binding]; other site
402626007921	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
402626007922	inter-subunit interface; other site
402626007923	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
402626007924	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626007925	catalytic loop [active]
402626007926	iron binding site [ion binding]; other site
402626007927	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
402626007928	FAD binding pocket [chemical binding]; other site
402626007929	FAD binding motif [chemical binding]; other site
402626007930	phosphate binding motif [ion binding]; other site
402626007931	beta-alpha-beta structure motif; other site
402626007932	NAD binding pocket [chemical binding]; other site
402626007933	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
402626007934	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
402626007935	putative NAD(P) binding site [chemical binding]; other site
402626007936	active site
402626007937	benzoate transport; Region: 2A0115; TIGR00895
402626007938	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626007939	putative substrate translocation pore; other site
402626007940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626007941	Benzoate membrane transport protein; Region: BenE; pfam03594
402626007942	benzoate transporter; Region: benE; TIGR00843
402626007943	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
402626007944	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
402626007945	inhibitor-cofactor binding pocket; inhibition site
402626007946	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626007947	catalytic residue [active]
402626007948	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
402626007949	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
402626007950	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
402626007951	catalytic residue [active]
402626007952	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
402626007953	AAA domain; Region: AAA_26; pfam13500
402626007954	Protein of unknown function (DUF1653); Region: DUF1653; cl01949
402626007955	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
402626007956	active site
402626007957	catalytic residues [active]
402626007958	metal binding site [ion binding]; metal-binding site
402626007959	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626007960	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626007961	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
402626007962	putative dimerization interface [polypeptide binding]; other site
402626007963	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
402626007964	CoA-transferase family III; Region: CoA_transf_3; pfam02515
402626007965	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
402626007966	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
402626007967	substrate binding site [chemical binding]; other site
402626007968	ligand binding site [chemical binding]; other site
402626007969	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
402626007970	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
402626007971	substrate binding site [chemical binding]; other site
402626007972	benzoate transport; Region: 2A0115; TIGR00895
402626007973	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626007974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626007975	hypothetical protein; Region: PHA01083
402626007976	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
402626007977	sequence-specific DNA binding site [nucleotide binding]; other site
402626007978	salt bridge; other site
402626007979	Replication initiation factor; Region: Rep_trans; pfam02486
402626007980	Protein of unknown function (DUF2523); Region: DUF2523; pfam10734
402626007981	Zonular occludens toxin (Zot); Region: Zot; cl17485
402626007982	Zonular occludens toxin (Zot); Region: Zot; cl17485
402626007983	Protein of unknown function (DUF2523); Region: DUF2523; pfam10734
402626007984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626007985	putative substrate translocation pore; other site
402626007986	Cupin; Region: Cupin_6; pfam12852
402626007987	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626007988	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
402626007989	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626007990	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
402626007991	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626007992	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
402626007993	dimerization interface [polypeptide binding]; other site
402626007994	citrate-proton symporter; Provisional; Region: PRK15075
402626007995	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626007996	putative substrate translocation pore; other site
402626007997	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
402626007998	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
402626007999	metal binding site [ion binding]; metal-binding site
402626008000	putative dimer interface [polypeptide binding]; other site
402626008001	amidase; Provisional; Region: PRK07486
402626008002	Amidase; Region: Amidase; pfam01425
402626008003	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626008004	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
402626008005	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
402626008006	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
402626008007	active site
402626008008	metal binding site [ion binding]; metal-binding site
402626008009	hexamer interface [polypeptide binding]; other site
402626008010	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
402626008011	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626008012	Walker A/P-loop; other site
402626008013	ATP binding site [chemical binding]; other site
402626008014	Q-loop/lid; other site
402626008015	ABC transporter signature motif; other site
402626008016	Walker B; other site
402626008017	D-loop; other site
402626008018	H-loop/switch region; other site
402626008019	TOBE domain; Region: TOBE_2; pfam08402
402626008020	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
402626008021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626008022	dimer interface [polypeptide binding]; other site
402626008023	conserved gate region; other site
402626008024	putative PBP binding loops; other site
402626008025	ABC-ATPase subunit interface; other site
402626008026	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
402626008027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626008028	dimer interface [polypeptide binding]; other site
402626008029	conserved gate region; other site
402626008030	putative PBP binding loops; other site
402626008031	ABC-ATPase subunit interface; other site
402626008032	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
402626008033	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
402626008034	Transcriptional regulators [Transcription]; Region: PurR; COG1609
402626008035	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
402626008036	DNA binding site [nucleotide binding]
402626008037	domain linker motif; other site
402626008038	Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282
402626008039	putative dimerization interface [polypeptide binding]; other site
402626008040	putative ligand binding site [chemical binding]; other site
402626008041	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
402626008042	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
402626008043	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
402626008044	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
402626008045	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
402626008046	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
402626008047	active site
402626008048	PilZ domain; Region: PilZ; cl01260
402626008049	DNA polymerase III subunit delta'; Validated; Region: PRK06964
402626008050	DNA polymerase III subunit delta'; Validated; Region: PRK08485
402626008051	thymidylate kinase; Validated; Region: tmk; PRK00698
402626008052	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
402626008053	TMP-binding site; other site
402626008054	ATP-binding site [chemical binding]; other site
402626008055	YceG-like family; Region: YceG; pfam02618
402626008056	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
402626008057	dimerization interface [polypeptide binding]; other site
402626008058	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
402626008059	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
402626008060	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
402626008061	Uncharacterized conserved protein [Function unknown]; Region: COG3332
402626008062	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
402626008063	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
402626008064	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626008065	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626008066	LysR substrate binding domain; Region: LysR_substrate; pfam03466
402626008067	dimerization interface [polypeptide binding]; other site
402626008068	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626008069	Coenzyme A binding pocket [chemical binding]; other site
402626008070	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
402626008071	active site
402626008072	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
402626008073	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
402626008074	substrate binding pocket [chemical binding]; other site
402626008075	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
402626008076	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
402626008077	putative active site [active]
402626008078	metal binding site [ion binding]; metal-binding site
402626008079	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
402626008080	hypothetical protein; Provisional; Region: PRK06194
402626008081	classical (c) SDRs; Region: SDR_c; cd05233
402626008082	NAD(P) binding site [chemical binding]; other site
402626008083	active site
402626008084	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
402626008085	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
402626008086	C-terminal domain interface [polypeptide binding]; other site
402626008087	GSH binding site (G-site) [chemical binding]; other site
402626008088	dimer interface [polypeptide binding]; other site
402626008089	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
402626008090	N-terminal domain interface [polypeptide binding]; other site
402626008091	hypothetical protein; Provisional; Region: PRK06208
402626008092	intersubunit interface [polypeptide binding]; other site
402626008093	active site
402626008094	Zn2+ binding site [ion binding]; other site
402626008095	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
402626008096	Prostaglandin dehydrogenases; Region: PGDH; cd05288
402626008097	NAD(P) binding site [chemical binding]; other site
402626008098	substrate binding site [chemical binding]; other site
402626008099	dimer interface [polypeptide binding]; other site
402626008100	Beta-lactamase; Region: Beta-lactamase; pfam00144
402626008101	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
402626008102	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
402626008103	CoenzymeA binding site [chemical binding]; other site
402626008104	subunit interaction site [polypeptide binding]; other site
402626008105	PHB binding site; other site
402626008106	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
402626008107	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626008108	NAD(P) binding site [chemical binding]; other site
402626008109	active site
402626008110	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
402626008111	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
402626008112	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
402626008113	FAD binding site [chemical binding]; other site
402626008114	substrate binding site [chemical binding]; other site
402626008115	catalytic residues [active]
402626008116	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
402626008117	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
402626008118	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
402626008119	dimer interface [polypeptide binding]; other site
402626008120	active site
402626008121	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
402626008122	Isochorismatase family; Region: Isochorismatase; pfam00857
402626008123	catalytic triad [active]
402626008124	metal binding site [ion binding]; metal-binding site
402626008125	conserved cis-peptide bond; other site
402626008126	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626008127	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
402626008128	substrate binding site [chemical binding]; other site
402626008129	oxyanion hole (OAH) forming residues; other site
402626008130	trimer interface [polypeptide binding]; other site
402626008131	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
402626008132	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
402626008133	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
402626008134	lysine transporter; Provisional; Region: PRK10836
402626008135	lysine transporter; Provisional; Region: PRK10836
402626008136	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
402626008137	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
402626008138	Walker A/P-loop; other site
402626008139	ATP binding site [chemical binding]; other site
402626008140	Q-loop/lid; other site
402626008141	ABC transporter signature motif; other site
402626008142	Walker B; other site
402626008143	D-loop; other site
402626008144	H-loop/switch region; other site
402626008145	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
402626008146	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
402626008147	Walker A/P-loop; other site
402626008148	ATP binding site [chemical binding]; other site
402626008149	Q-loop/lid; other site
402626008150	ABC transporter signature motif; other site
402626008151	Walker B; other site
402626008152	D-loop; other site
402626008153	H-loop/switch region; other site
402626008154	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
402626008155	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
402626008156	TM-ABC transporter signature motif; other site
402626008157	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
402626008158	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626008159	TM-ABC transporter signature motif; other site
402626008160	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
402626008161	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
402626008162	putative ligand binding site [chemical binding]; other site
402626008163	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
402626008164	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
402626008165	dimer interface [polypeptide binding]; other site
402626008166	acyl-activating enzyme (AAE) consensus motif; other site
402626008167	putative active site [active]
402626008168	AMP binding site [chemical binding]; other site
402626008169	putative CoA binding site [chemical binding]; other site
402626008170	Uncharacterized conserved protein [Function unknown]; Region: COG0397
402626008171	hypothetical protein; Validated; Region: PRK00029
402626008172	methionine sulfoxide reductase B; Provisional; Region: PRK00222
402626008173	SelR domain; Region: SelR; pfam01641
402626008174	intracellular septation protein A; Reviewed; Region: PRK00259
402626008175	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
402626008176	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
402626008177	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
402626008178	zinc binding site [ion binding]; other site
402626008179	putative ligand binding site [chemical binding]; other site
402626008180	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626008181	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
402626008182	TM-ABC transporter signature motif; other site
402626008183	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
402626008184	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626008185	Walker A/P-loop; other site
402626008186	ATP binding site [chemical binding]; other site
402626008187	Q-loop/lid; other site
402626008188	ABC transporter signature motif; other site
402626008189	Walker B; other site
402626008190	D-loop; other site
402626008191	H-loop/switch region; other site
402626008192	DnaJ domain; Region: DnaJ; pfam00226
402626008193	HSP70 interaction site [polypeptide binding]; other site
402626008194	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
402626008195	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
402626008196	Walker A/P-loop; other site
402626008197	ATP binding site [chemical binding]; other site
402626008198	Q-loop/lid; other site
402626008199	ABC transporter signature motif; other site
402626008200	Walker B; other site
402626008201	D-loop; other site
402626008202	H-loop/switch region; other site
402626008203	TOBE domain; Region: TOBE_2; pfam08402
402626008204	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
402626008205	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
402626008206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626008207	dimer interface [polypeptide binding]; other site
402626008208	conserved gate region; other site
402626008209	putative PBP binding loops; other site
402626008210	ABC-ATPase subunit interface; other site
402626008211	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
402626008212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626008213	dimer interface [polypeptide binding]; other site
402626008214	conserved gate region; other site
402626008215	putative PBP binding loops; other site
402626008216	ABC-ATPase subunit interface; other site
402626008217	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626008218	NAD(P) binding site [chemical binding]; other site
402626008219	active site
402626008220	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
402626008221	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
402626008222	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
402626008223	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
402626008224	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626008225	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626008226	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626008227	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
402626008228	putative effector binding pocket; other site
402626008229	putative dimerization interface [polypeptide binding]; other site
402626008230	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
402626008231	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626008232	substrate binding pocket [chemical binding]; other site
402626008233	membrane-bound complex binding site; other site
402626008234	hinge residues; other site
402626008235	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
402626008236	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
402626008237	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
402626008238	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
402626008239	catalytic residues [active]
402626008240	catalytic nucleophile [active]
402626008241	Presynaptic Site I dimer interface [polypeptide binding]; other site
402626008242	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
402626008243	Synaptic Flat tetramer interface [polypeptide binding]; other site
402626008244	Synaptic Site I dimer interface [polypeptide binding]; other site
402626008245	DNA binding site [nucleotide binding]
402626008246	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
402626008247	DNA-binding interface [nucleotide binding]; DNA binding site
402626008248	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
402626008249	Chlorite dismutase; Region: Chlor_dismutase; cl01280
402626008250	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
402626008251	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
402626008252	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
402626008253	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
402626008254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
402626008255	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
402626008256	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
402626008257	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
402626008258	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
402626008259	Predicted membrane protein [Function unknown]; Region: COG2246
402626008260	GtrA-like protein; Region: GtrA; pfam04138
402626008261	Methyltransferase domain; Region: Methyltransf_23; pfam13489
402626008262	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626008263	S-adenosylmethionine binding site [chemical binding]; other site
402626008264	Helix-turn-helix domain; Region: HTH_28; pfam13518
402626008265	Winged helix-turn helix; Region: HTH_29; pfam13551
402626008266	Winged helix-turn helix; Region: HTH_33; pfam13592
402626008267	DDE superfamily endonuclease; Region: DDE_3; pfam13358
402626008268	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
402626008269	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626008270	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626008271	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626008272	dimerization interface [polypeptide binding]; other site
402626008273	AAA ATPase domain; Region: AAA_16; pfam13191
402626008274	AAA domain; Region: AAA_22; pfam13401
402626008275	Integrase core domain; Region: rve; pfam00665
402626008276	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
402626008277	TraB family; Region: TraB; pfam01963
402626008278	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
402626008279	IHF - DNA interface [nucleotide binding]; other site
402626008280	IHF dimer interface [polypeptide binding]; other site
402626008281	Restriction endonuclease; Region: Mrr_cat; pfam04471
402626008282	Phage integrase protein; Region: DUF3701; pfam12482
402626008283	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
402626008284	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
402626008285	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
402626008286	Int/Topo IB signature motif; other site
402626008287	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
402626008288	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
402626008289	P-loop; other site
402626008290	Magnesium ion binding site [ion binding]; other site
402626008291	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
402626008292	ParB-like nuclease domain; Region: ParBc; pfam02195
402626008293	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
402626008294	Initiator Replication protein; Region: Rep_3; pfam01051
402626008295	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
402626008296	Family description; Region: UvrD_C_2; pfam13538
402626008297	Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247
402626008298	Domain of unknown function (DUF4400); Region: DUF4400; pfam14348
402626008299	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
402626008300	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
402626008301	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
402626008302	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
402626008303	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
402626008304	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
402626008305	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
402626008306	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
402626008307	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
402626008308	Walker A motif; other site
402626008309	hexamer interface [polypeptide binding]; other site
402626008310	ATP binding site [chemical binding]; other site
402626008311	Walker B motif; other site
402626008312	VirB8 protein; Region: VirB8; pfam04335
402626008313	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
402626008314	VirB7 interaction site; other site
402626008315	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
402626008316	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
402626008317	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
402626008318	VirB7 interaction site; other site
402626008319	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
402626008320	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
402626008321	N-acetyl-D-glucosamine binding site [chemical binding]; other site
402626008322	catalytic residue [active]
402626008323	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
402626008324	type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520
402626008325	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
402626008326	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
402626008327	type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021
402626008328	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
402626008329	Walker A motif; other site
402626008330	ATP binding site [chemical binding]; other site
402626008331	Walker B motif; other site
402626008332	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
402626008333	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
402626008334	Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917
402626008335	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
402626008336	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
402626008337	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
402626008338	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
402626008339	dimer interface [polypeptide binding]; other site
402626008340	ssDNA binding site [nucleotide binding]; other site
402626008341	tetramer (dimer of dimers) interface [polypeptide binding]; other site
402626008342	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
402626008343	Toprim domain; Region: Toprim_3; pfam13362
402626008344	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
402626008345	PRTRC system protein D; Region: PRTRC_D; TIGR03739
402626008346	Mg binding site [ion binding]; other site
402626008347	nucleotide binding site [chemical binding]; other site
402626008348	putative protofilament interface [polypeptide binding]; other site
402626008349	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
402626008350	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
402626008351	active site
402626008352	catalytic residues [active]
402626008353	Int/Topo IB signature motif; other site
402626008354	DNA binding site [nucleotide binding]
402626008355	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
402626008356	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
402626008357	active site
402626008358	substrate binding site [chemical binding]; other site
402626008359	Mg2+ binding site [ion binding]; other site
402626008360	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
402626008361	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
402626008362	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
402626008363	Family description; Region: UvrD_C_2; pfam13538
402626008364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626008365	Walker A motif; other site
402626008366	ATP binding site [chemical binding]; other site
402626008367	Walker B motif; other site
402626008368	arginine finger; other site
402626008369	Predicted ATPase [General function prediction only]; Region: COG5293
402626008370	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
402626008371	TniQ; Region: TniQ; pfam06527
402626008372	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626008373	AAA domain; Region: AAA_22; pfam13401
402626008374	Walker A motif; other site
402626008375	ATP binding site [chemical binding]; other site
402626008376	Walker B motif; other site
402626008377	Integrase core domain; Region: rve; pfam00665
402626008378	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
402626008379	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
402626008380	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
402626008381	EamA-like transporter family; Region: EamA; pfam00892
402626008382	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
402626008383	EamA-like transporter family; Region: EamA; pfam00892
402626008384	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
402626008385	putative metal binding site [ion binding]; other site
402626008386	putative homodimer interface [polypeptide binding]; other site
402626008387	putative homotetramer interface [polypeptide binding]; other site
402626008388	putative homodimer-homodimer interface [polypeptide binding]; other site
402626008389	putative allosteric switch controlling residues; other site
402626008390	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
402626008391	Cation efflux family; Region: Cation_efflux; cl00316
402626008392	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
402626008393	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
402626008394	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
402626008395	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
402626008396	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
402626008397	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
402626008398	Ligand Binding Site [chemical binding]; other site
402626008399	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
402626008400	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
402626008401	ParB-like nuclease domain; Region: ParBc; pfam02195
402626008402	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
402626008403	PRTRC system protein E; Region: PRTRC_E; TIGR03741
402626008404	PRTRC system protein C; Region: PRTRC_C; TIGR03738
402626008405	Alpha-helical domain 2; Region: alpha-hel2; pfam14456
402626008406	PRTRC system protein B; Region: PRTRC_B; TIGR03737
402626008407	Domain of unknown function (DUF2016); Region: DUF2016; pfam09436
402626008408	PRTRC system protein A; Region: PRTRC_A; TIGR03735
402626008409	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
402626008410	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
402626008411	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
402626008412	ATP binding site [chemical binding]; other site
402626008413	substrate interface [chemical binding]; other site
402626008414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
402626008415	SPFH domain / Band 7 family; Region: Band_7; pfam01145
402626008416	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
402626008417	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626008418	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
402626008419	Walker A motif; other site
402626008420	ATP binding site [chemical binding]; other site
402626008421	Walker B motif; other site
402626008422	arginine finger; other site
402626008423	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
402626008424	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
402626008425	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
402626008426	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
402626008427	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
402626008428	active site
402626008429	metal binding site [ion binding]; metal-binding site
402626008430	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
402626008431	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626008432	Walker A/P-loop; other site
402626008433	ATP binding site [chemical binding]; other site
402626008434	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
402626008435	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
402626008436	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
402626008437	DNA binding site [nucleotide binding]
402626008438	dimer interface [polypeptide binding]; other site
402626008439	active site
402626008440	Int/Topo IB signature motif; other site
402626008441	Cytochrome c; Region: Cytochrom_C; pfam00034
402626008442	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
402626008443	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
402626008444	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
402626008445	DNA binding residues [nucleotide binding]
402626008446	dimer interface [polypeptide binding]; other site
402626008447	putative metal binding site [ion binding]; other site
402626008448	Heavy-metal-associated domain; Region: HMA; pfam00403
402626008449	metal-binding site [ion binding]
402626008450	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
402626008451	Heavy-metal-associated domain; Region: HMA; pfam00403
402626008452	metal-binding site [ion binding]
402626008453	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626008454	Soluble P-type ATPase [General function prediction only]; Region: COG4087
402626008455	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
402626008456	active site
402626008457	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
402626008458	Uncharacterized conserved protein [Function unknown]; Region: COG5569
402626008459	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
402626008460	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
402626008461	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626008462	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
402626008463	Outer membrane efflux protein; Region: OEP; pfam02321
402626008464	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
402626008465	Uncharacterized conserved protein [Function unknown]; Region: COG3350
402626008466	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
402626008467	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626008468	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626008469	motif II; other site
402626008470	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
402626008471	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
402626008472	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
402626008473	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
402626008474	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
402626008475	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
402626008476	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
402626008477	Walker A/P-loop; other site
402626008478	ATP binding site [chemical binding]; other site
402626008479	Q-loop/lid; other site
402626008480	ABC transporter signature motif; other site
402626008481	Walker B; other site
402626008482	D-loop; other site
402626008483	H-loop/switch region; other site
402626008484	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
402626008485	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
402626008486	FtsX-like permease family; Region: FtsX; pfam02687
402626008487	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
402626008488	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
402626008489	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
402626008490	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
402626008491	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
402626008492	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
402626008493	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
402626008494	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626008495	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626008496	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
402626008497	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
402626008498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626008499	active site
402626008500	phosphorylation site [posttranslational modification]
402626008501	intermolecular recognition site; other site
402626008502	dimerization interface [polypeptide binding]; other site
402626008503	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626008504	DNA binding residues [nucleotide binding]
402626008505	dimerization interface [polypeptide binding]; other site
402626008506	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
402626008507	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626008508	dimerization interface [polypeptide binding]; other site
402626008509	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626008510	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626008511	dimer interface [polypeptide binding]; other site
402626008512	phosphorylation site [posttranslational modification]
402626008513	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626008514	ATP binding site [chemical binding]; other site
402626008515	Mg2+ binding site [ion binding]; other site
402626008516	G-X-G motif; other site
402626008517	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
402626008518	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
402626008519	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
402626008520	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
402626008521	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
402626008522	putative metal binding site [ion binding]; other site
402626008523	putative homodimer interface [polypeptide binding]; other site
402626008524	putative homotetramer interface [polypeptide binding]; other site
402626008525	putative homodimer-homodimer interface [polypeptide binding]; other site
402626008526	putative allosteric switch controlling residues; other site
402626008527	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
402626008528	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
402626008529	Integrase core domain; Region: rve; pfam00665
402626008530	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
402626008531	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626008532	AAA domain; Region: AAA_22; pfam13401
402626008533	Walker A motif; other site
402626008534	ATP binding site [chemical binding]; other site
402626008535	Walker B motif; other site
402626008536	TniQ; Region: TniQ; pfam06527
402626008537	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
402626008538	active site
402626008539	ATP binding site [chemical binding]; other site
402626008540	substrate binding site [chemical binding]; other site
402626008541	activation loop (A-loop); other site
402626008542	Domain of unknown function (DUF4338); Region: DUF4338; pfam14236
402626008543	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
402626008544	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
402626008545	putative active site [active]
402626008546	putative metal binding site [ion binding]; other site
402626008547	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626008548	Walker A motif; other site
402626008549	ATP binding site [chemical binding]; other site
402626008550	Walker B motif; other site
402626008551	arginine finger; other site
402626008552	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
402626008553	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
402626008554	FtsX-like permease family; Region: FtsX; pfam02687
402626008555	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
402626008556	ABC1 family; Region: ABC1; cl17513
402626008557	S-adenosylmethionine synthetase (AdoMet synthetase); Region: AdoMet_Synthase; pfam01941
402626008558	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
402626008559	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
402626008560	Repair protein; Region: Repair_PSII; pfam04536
402626008561	Repair protein; Region: Repair_PSII; cl01535
402626008562	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
402626008563	FtsH Extracellular; Region: FtsH_ext; pfam06480
402626008564	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
402626008565	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626008566	Walker A motif; other site
402626008567	ATP binding site [chemical binding]; other site
402626008568	Walker B motif; other site
402626008569	arginine finger; other site
402626008570	Peptidase family M41; Region: Peptidase_M41; pfam01434
402626008571	myosin-cross-reactive antigen; Provisional; Region: PRK13977
402626008572	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
402626008573	metal-binding site [ion binding]
402626008574	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
402626008575	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
402626008576	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
402626008577	Beta-Casp domain; Region: Beta-Casp; smart01027
402626008578	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
402626008579	thymidine phosphorylase; Provisional; Region: PRK04350
402626008580	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
402626008581	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
402626008582	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
402626008583	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
402626008584	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
402626008585	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
402626008586	active site
402626008587	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
402626008588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626008589	S-adenosylmethionine binding site [chemical binding]; other site
402626008590	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
402626008591	metal-binding site [ion binding]
402626008592	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
402626008593	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626008594	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626008595	motif II; other site
402626008596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626008597	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626008598	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
402626008599	dimerization interface [polypeptide binding]; other site
402626008600	CopC domain; Region: CopC; pfam04234
402626008601	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
402626008602	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626008603	dimerization interface [polypeptide binding]; other site
402626008604	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626008605	dimer interface [polypeptide binding]; other site
402626008606	phosphorylation site [posttranslational modification]
402626008607	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626008608	ATP binding site [chemical binding]; other site
402626008609	Mg2+ binding site [ion binding]; other site
402626008610	G-X-G motif; other site
402626008611	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
402626008612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626008613	active site
402626008614	phosphorylation site [posttranslational modification]
402626008615	intermolecular recognition site; other site
402626008616	dimerization interface [polypeptide binding]; other site
402626008617	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626008618	DNA binding site [nucleotide binding]
402626008619	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
402626008620	Multicopper oxidase; Region: Cu-oxidase; pfam00394
402626008621	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
402626008622	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
402626008623	CopC domain; Region: CopC; pfam04234
402626008624	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
402626008625	Protein of unknown function, DUF; Region: DUF411; cl01142
402626008626	putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183
402626008627	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
402626008628	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
402626008629	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
402626008630	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
402626008631	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
402626008632	active site
402626008633	Int/Topo IB signature motif; other site
402626008634	catalytic residues [active]
402626008635	DNA binding site [nucleotide binding]
402626008636	H-NS histone family; Region: Histone_HNS; pfam00816
402626008637	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
402626008638	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
402626008639	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
402626008640	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
402626008641	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
402626008642	Int/Topo IB signature motif; other site
402626008643	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
402626008644	Predicted transcriptional regulator [Transcription]; Region: COG3905
402626008645	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
402626008646	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
402626008647	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
402626008648	Phage integrase protein; Region: DUF3701; pfam12482
402626008649	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
402626008650	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
402626008651	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
402626008652	Int/Topo IB signature motif; other site
402626008653	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
402626008654	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626008655	dimerization interface [polypeptide binding]; other site
402626008656	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626008657	dimer interface [polypeptide binding]; other site
402626008658	phosphorylation site [posttranslational modification]
402626008659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626008660	ATP binding site [chemical binding]; other site
402626008661	Mg2+ binding site [ion binding]; other site
402626008662	G-X-G motif; other site
402626008663	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
402626008664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626008665	active site
402626008666	phosphorylation site [posttranslational modification]
402626008667	intermolecular recognition site; other site
402626008668	dimerization interface [polypeptide binding]; other site
402626008669	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626008670	DNA binding site [nucleotide binding]
402626008671	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
402626008672	dimerization interface [polypeptide binding]; other site
402626008673	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
402626008674	Phage integrase protein; Region: DUF3701; pfam12482
402626008675	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
402626008676	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
402626008677	Int/Topo IB signature motif; other site
402626008678	Mechanosensitive ion channel; Region: MS_channel; pfam00924
402626008679	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
402626008680	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
402626008681	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
402626008682	GtrA-like protein; Region: GtrA; pfam04138
402626008683	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
402626008684	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
402626008685	Ligand binding site; other site
402626008686	Putative Catalytic site; other site
402626008687	DXD motif; other site
402626008688	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
402626008689	Double zinc ribbon; Region: DZR; pfam12773
402626008690	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
402626008691	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626008692	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
402626008693	Soluble P-type ATPase [General function prediction only]; Region: COG4087
402626008694	Helix-turn-helix domain; Region: HTH_28; pfam13518
402626008695	Winged helix-turn helix; Region: HTH_29; pfam13551
402626008696	Winged helix-turn helix; Region: HTH_33; pfam13592
402626008697	DDE superfamily endonuclease; Region: DDE_3; pfam13358
402626008698	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
402626008699	flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
402626008700	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
402626008701	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626008702	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626008703	trimer interface [polypeptide binding]; other site
402626008704	eyelet of channel; other site
402626008705	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
402626008706	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626008707	dimerization interface [polypeptide binding]; other site
402626008708	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626008709	dimer interface [polypeptide binding]; other site
402626008710	phosphorylation site [posttranslational modification]
402626008711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626008712	ATP binding site [chemical binding]; other site
402626008713	Mg2+ binding site [ion binding]; other site
402626008714	G-X-G motif; other site
402626008715	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
402626008716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626008717	active site
402626008718	phosphorylation site [posttranslational modification]
402626008719	intermolecular recognition site; other site
402626008720	dimerization interface [polypeptide binding]; other site
402626008721	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626008722	DNA binding site [nucleotide binding]
402626008723	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
402626008724	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
402626008725	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
402626008726	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
402626008727	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626008728	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
402626008729	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
402626008730	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
402626008731	MgtC family; Region: MgtC; pfam02308
402626008732	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
402626008733	Predicted metal-binding protein [General function prediction only]; Region: COG3019
402626008734	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
402626008735	CopC domain; Region: CopC; pfam04234
402626008736	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
402626008737	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
402626008738	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
402626008739	Multicopper oxidase; Region: Cu-oxidase; pfam00394
402626008740	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
402626008741	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
402626008742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626008743	active site
402626008744	phosphorylation site [posttranslational modification]
402626008745	intermolecular recognition site; other site
402626008746	dimerization interface [polypeptide binding]; other site
402626008747	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626008748	DNA binding site [nucleotide binding]
402626008749	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
402626008750	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626008751	dimerization interface [polypeptide binding]; other site
402626008752	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626008753	dimer interface [polypeptide binding]; other site
402626008754	phosphorylation site [posttranslational modification]
402626008755	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626008756	ATP binding site [chemical binding]; other site
402626008757	Mg2+ binding site [ion binding]; other site
402626008758	G-X-G motif; other site
402626008759	putative transcriptional regulator MerR; Provisional; Region: PRK13752
402626008760	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
402626008761	DNA binding residues [nucleotide binding]
402626008762	dimer interface [polypeptide binding]; other site
402626008763	mercury binding site [ion binding]; other site
402626008764	putative mercuric transport protein; Provisional; Region: PRK13751
402626008765	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
402626008766	metal-binding site [ion binding]
402626008767	putative mercury transport protein MerC; Provisional; Region: PRK13755
402626008768	putative mercuric reductase; Provisional; Region: PRK13748
402626008769	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
402626008770	metal-binding site [ion binding]
402626008771	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
402626008772	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
402626008773	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
402626008774	mercuric resistence transcriptional repressor protein MerD; Region: MerD; TIGR02054
402626008775	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
402626008776	DNA binding residues [nucleotide binding]
402626008777	Alkylmercury lyase; Region: MerB; pfam03243
402626008778	Cytochrome c; Region: Cytochrom_C; cl11414
402626008779	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
402626008780	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
402626008781	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
402626008782	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
402626008783	DsbD alpha interface [polypeptide binding]; other site
402626008784	catalytic residues [active]
402626008785	Nitrogen regulatory protein P-II; Region: P-II; cl00412
402626008786	Nitrogen regulatory protein P-II; Region: P-II; smart00938
402626008787	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
402626008788	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
402626008789	[2Fe-2S] cluster binding site [ion binding]; other site
402626008790	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
402626008791	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
402626008792	AhpC/TSA family; Region: AhpC-TSA; pfam00578
402626008793	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
402626008794	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
402626008795	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
402626008796	YHS domain; Region: YHS; pfam04945
402626008797	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
402626008798	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626008799	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626008800	motif II; other site
402626008801	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
402626008802	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
402626008803	DNA binding residues [nucleotide binding]
402626008804	dimer interface [polypeptide binding]; other site
402626008805	copper binding site [ion binding]; other site
402626008806	Outer membrane efflux protein; Region: OEP; pfam02321
402626008807	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
402626008808	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626008809	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
402626008810	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
402626008811	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
402626008812	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
402626008813	active site
402626008814	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
402626008815	lipoprotein signal peptidase; Provisional; Region: PRK14787
402626008816	Heavy-metal-associated domain; Region: HMA; pfam00403
402626008817	metal-binding site [ion binding]
402626008818	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
402626008819	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
402626008820	metal-binding site [ion binding]
402626008821	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626008822	Soluble P-type ATPase [General function prediction only]; Region: COG4087
402626008823	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
402626008824	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
402626008825	DNA binding residues [nucleotide binding]
402626008826	dimer interface [polypeptide binding]; other site
402626008827	putative metal binding site [ion binding]; other site
402626008828	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
402626008829	Cytochrome c; Region: Cytochrom_C; pfam00034
402626008830	Iron permease FTR1 family; Region: FTR1; cl00475
402626008831	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626008832	Coenzyme A binding pocket [chemical binding]; other site
402626008833	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
402626008834	amphipathic channel; other site
402626008835	Asn-Pro-Ala signature motifs; other site
402626008836	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
402626008837	Low molecular weight phosphatase family; Region: LMWPc; cd00115
402626008838	active site
402626008839	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
402626008840	Low molecular weight phosphatase family; Region: LMWPc; cd00115
402626008841	active site
402626008842	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
402626008843	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626008844	putative metal binding site [ion binding]; other site
402626008845	Phage integrase protein; Region: DUF3701; pfam12482
402626008846	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
402626008847	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
402626008848	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
402626008849	Int/Topo IB signature motif; other site
402626008850	putative transposase OrfB; Reviewed; Region: PHA02517
402626008851	HTH-like domain; Region: HTH_21; pfam13276
402626008852	Integrase core domain; Region: rve; pfam00665
402626008853	Integrase core domain; Region: rve_3; pfam13683
402626008854	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
402626008855	Protein of unknown function, DUF; Region: DUF411; cl01142
402626008856	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
402626008857	CopC domain; Region: CopC; pfam04234
402626008858	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
402626008859	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
402626008860	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
402626008861	Multicopper oxidase; Region: Cu-oxidase; pfam00394
402626008862	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
402626008863	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
402626008864	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626008865	active site
402626008866	phosphorylation site [posttranslational modification]
402626008867	intermolecular recognition site; other site
402626008868	dimerization interface [polypeptide binding]; other site
402626008869	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626008870	DNA binding site [nucleotide binding]
402626008871	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
402626008872	HAMP domain; Region: HAMP; pfam00672
402626008873	dimerization interface [polypeptide binding]; other site
402626008874	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626008875	dimer interface [polypeptide binding]; other site
402626008876	phosphorylation site [posttranslational modification]
402626008877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626008878	ATP binding site [chemical binding]; other site
402626008879	Mg2+ binding site [ion binding]; other site
402626008880	G-X-G motif; other site
402626008881	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
402626008882	dimerization interface [polypeptide binding]; other site
402626008883	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
402626008884	ApbE family; Region: ApbE; pfam02424
402626008885	FMN-binding domain; Region: FMN_bind; pfam04205
402626008886	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
402626008887	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626008888	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626008889	motif II; other site
402626008890	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
402626008891	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
402626008892	Multicopper oxidase; Region: Cu-oxidase; pfam00394
402626008893	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
402626008894	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
402626008895	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
402626008896	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
402626008897	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
402626008898	catalytic residues [active]
402626008899	catalytic nucleophile [active]
402626008900	Presynaptic Site I dimer interface [polypeptide binding]; other site
402626008901	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
402626008902	Synaptic Flat tetramer interface [polypeptide binding]; other site
402626008903	Synaptic Site I dimer interface [polypeptide binding]; other site
402626008904	DNA binding site [nucleotide binding]
402626008905	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
402626008906	DNA-binding interface [nucleotide binding]; DNA binding site
402626008907	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
402626008908	Chlorite dismutase; Region: Chlor_dismutase; cl01280
402626008909	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
402626008910	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
402626008911	Autotransporter beta-domain; Region: Autotransporter; pfam03797
402626008912	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
402626008913	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
402626008914	dimerization interface [polypeptide binding]; other site
402626008915	ATP binding site [chemical binding]; other site
402626008916	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
402626008917	dimerization interface [polypeptide binding]; other site
402626008918	ATP binding site [chemical binding]; other site
402626008919	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
402626008920	putative active site [active]
402626008921	catalytic triad [active]
402626008922	Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631
402626008923	Uncharacterized conserved protein [Function unknown]; Region: COG0062
402626008924	putative carbohydrate kinase; Provisional; Region: PRK10565
402626008925	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
402626008926	putative substrate binding site [chemical binding]; other site
402626008927	putative ATP binding site [chemical binding]; other site
402626008928	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
402626008929	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
402626008930	active site
402626008931	dimer interface [polypeptide binding]; other site
402626008932	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
402626008933	dimer interface [polypeptide binding]; other site
402626008934	active site
402626008935	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
402626008936	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
402626008937	Walker A/P-loop; other site
402626008938	ATP binding site [chemical binding]; other site
402626008939	Q-loop/lid; other site
402626008940	ABC transporter signature motif; other site
402626008941	Walker B; other site
402626008942	D-loop; other site
402626008943	H-loop/switch region; other site
402626008944	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
402626008945	active site
402626008946	catalytic triad [active]
402626008947	oxyanion hole [active]
402626008948	switch loop; other site
402626008949	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
402626008950	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
402626008951	Catalytic site [active]
402626008952	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
402626008953	SurA N-terminal domain; Region: SurA_N_3; cl07813
402626008954	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
402626008955	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
402626008956	IHF dimer interface [polypeptide binding]; other site
402626008957	IHF - DNA interface [nucleotide binding]; other site
402626008958	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
402626008959	Found in ATP-dependent protease La (LON); Region: LON; smart00464
402626008960	Found in ATP-dependent protease La (LON); Region: LON; smart00464
402626008961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626008962	Walker A motif; other site
402626008963	ATP binding site [chemical binding]; other site
402626008964	Walker B motif; other site
402626008965	arginine finger; other site
402626008966	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
402626008967	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
402626008968	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
402626008969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626008970	Walker A motif; other site
402626008971	ATP binding site [chemical binding]; other site
402626008972	Walker B motif; other site
402626008973	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
402626008974	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
402626008975	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
402626008976	oligomer interface [polypeptide binding]; other site
402626008977	active site residues [active]
402626008978	trigger factor; Provisional; Region: tig; PRK01490
402626008979	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
402626008980	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
402626008981	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
402626008982	Uncharacterized conserved protein [Function unknown]; Region: COG4121
402626008983	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
402626008984	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
402626008985	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
402626008986	Subunit I/III interface [polypeptide binding]; other site
402626008987	Subunit III/IV interface [polypeptide binding]; other site
402626008988	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
402626008989	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
402626008990	D-pathway; other site
402626008991	Putative ubiquinol binding site [chemical binding]; other site
402626008992	Low-spin heme (heme b) binding site [chemical binding]; other site
402626008993	Putative water exit pathway; other site
402626008994	Binuclear center (heme o3/CuB) [ion binding]; other site
402626008995	K-pathway; other site
402626008996	Putative proton exit pathway; other site
402626008997	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
402626008998	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
402626008999	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
402626009000	metabolite-proton symporter; Region: 2A0106; TIGR00883
402626009001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626009002	putative substrate translocation pore; other site
402626009003	CsbD-like; Region: CsbD; pfam05532
402626009004	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
402626009005	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
402626009006	benzoate transport; Region: 2A0115; TIGR00895
402626009007	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626009008	putative substrate translocation pore; other site
402626009009	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626009010	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626009011	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
402626009012	putative dimerization interface [polypeptide binding]; other site
402626009013	ApbE family; Region: ApbE; pfam02424
402626009014	FMN-binding domain; Region: FMN_bind; pfam04205
402626009015	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
402626009016	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
402626009017	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626009018	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
402626009019	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626009020	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
402626009021	active site lid residues [active]
402626009022	substrate binding pocket [chemical binding]; other site
402626009023	catalytic residues [active]
402626009024	substrate-Mg2+ binding site; other site
402626009025	aspartate-rich region 1; other site
402626009026	aspartate-rich region 2; other site
402626009027	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
402626009028	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267
402626009029	osmolarity response regulator; Provisional; Region: ompR; PRK09468
402626009030	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626009031	active site
402626009032	phosphorylation site [posttranslational modification]
402626009033	intermolecular recognition site; other site
402626009034	dimerization interface [polypeptide binding]; other site
402626009035	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626009036	DNA binding site [nucleotide binding]
402626009037	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
402626009038	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626009039	dimerization interface [polypeptide binding]; other site
402626009040	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626009041	ATP binding site [chemical binding]; other site
402626009042	Mg2+ binding site [ion binding]; other site
402626009043	G-X-G motif; other site
402626009044	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
402626009045	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
402626009046	dimer interface [polypeptide binding]; other site
402626009047	decamer (pentamer of dimers) interface [polypeptide binding]; other site
402626009048	catalytic triad [active]
402626009049	peroxidatic and resolving cysteines [active]
402626009050	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
402626009051	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
402626009052	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
402626009053	homotrimer interaction site [polypeptide binding]; other site
402626009054	zinc binding site [ion binding]; other site
402626009055	CDP-binding sites; other site
402626009056	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
402626009057	substrate binding site; other site
402626009058	dimer interface; other site
402626009059	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
402626009060	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
402626009061	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
402626009062	ATP binding site [chemical binding]; other site
402626009063	putative Mg++ binding site [ion binding]; other site
402626009064	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
402626009065	nucleotide binding region [chemical binding]; other site
402626009066	ATP-binding site [chemical binding]; other site
402626009067	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
402626009068	acetylornithine deacetylase; Provisional; Region: PRK07522
402626009069	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
402626009070	metal binding site [ion binding]; metal-binding site
402626009071	putative dimer interface [polypeptide binding]; other site
402626009072	Domain of unknown function (DUF4072); Region: DUF4072; pfam13284
402626009073	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
402626009074	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626009075	motif II; other site
402626009076	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
402626009077	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
402626009078	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
402626009079	cystathionine beta-lyase; Provisional; Region: PRK07050
402626009080	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
402626009081	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
402626009082	catalytic residue [active]
402626009083	beta-ketothiolase; Provisional; Region: PRK09051
402626009084	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
402626009085	dimer interface [polypeptide binding]; other site
402626009086	active site
402626009087	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
402626009088	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
402626009089	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626009090	FeS/SAM binding site; other site
402626009091	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
402626009092	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
402626009093	FMN binding site [chemical binding]; other site
402626009094	active site
402626009095	catalytic residues [active]
402626009096	substrate binding site [chemical binding]; other site
402626009097	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
402626009098	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
402626009099	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
402626009100	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
402626009101	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
402626009102	NAD(P) binding site [chemical binding]; other site
402626009103	homotetramer interface [polypeptide binding]; other site
402626009104	homodimer interface [polypeptide binding]; other site
402626009105	active site
402626009106	putative acyltransferase; Provisional; Region: PRK05790
402626009107	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
402626009108	dimer interface [polypeptide binding]; other site
402626009109	active site
402626009110	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
402626009111	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
402626009112	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
402626009113	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
402626009114	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
402626009115	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
402626009116	RNA binding surface [nucleotide binding]; other site
402626009117	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
402626009118	active site
402626009119	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
402626009120	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
402626009121	DEAD/DEAH box helicase; Region: DEAD; pfam00270
402626009122	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
402626009123	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
402626009124	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
402626009125	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
402626009126	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
402626009127	RNA binding site [nucleotide binding]; other site
402626009128	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
402626009129	potassium uptake protein; Region: kup; TIGR00794
402626009130	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
402626009131	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
402626009132	quinone interaction residues [chemical binding]; other site
402626009133	active site
402626009134	catalytic residues [active]
402626009135	FMN binding site [chemical binding]; other site
402626009136	substrate binding site [chemical binding]; other site
402626009137	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
402626009138	nudix motif; other site
402626009139	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
402626009140	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
402626009141	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
402626009142	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
402626009143	TM2 domain; Region: TM2; pfam05154
402626009144	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
402626009145	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
402626009146	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
402626009147	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
402626009148	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
402626009149	Cysteine-rich domain; Region: CCG; pfam02754
402626009150	Cysteine-rich domain; Region: CCG; pfam02754
402626009151	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
402626009152	Transcriptional regulator [Transcription]; Region: IclR; COG1414
402626009153	Bacterial transcriptional regulator; Region: IclR; pfam01614
402626009154	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
402626009155	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
402626009156	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
402626009157	putative FMN binding site [chemical binding]; other site
402626009158	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
402626009159	active site
402626009160	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
402626009161	EamA-like transporter family; Region: EamA; pfam00892
402626009162	EamA-like transporter family; Region: EamA; pfam00892
402626009163	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
402626009164	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
402626009165	putative active site [active]
402626009166	Zn binding site [ion binding]; other site
402626009167	Phasin protein; Region: Phasin_2; pfam09361
402626009168	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
402626009169	E3 interaction surface; other site
402626009170	lipoyl attachment site [posttranslational modification]; other site
402626009171	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
402626009172	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
402626009173	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
402626009174	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
402626009175	active site
402626009176	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
402626009177	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
402626009178	E3 interaction surface; other site
402626009179	lipoyl attachment site [posttranslational modification]; other site
402626009180	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
402626009181	E3 interaction surface; other site
402626009182	lipoyl attachment site [posttranslational modification]; other site
402626009183	e3 binding domain; Region: E3_binding; pfam02817
402626009184	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
402626009185	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
402626009186	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
402626009187	dimer interface [polypeptide binding]; other site
402626009188	TPP-binding site [chemical binding]; other site
402626009189	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
402626009190	PAS domain S-box; Region: sensory_box; TIGR00229
402626009191	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626009192	putative active site [active]
402626009193	heme pocket [chemical binding]; other site
402626009194	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
402626009195	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626009196	dimer interface [polypeptide binding]; other site
402626009197	phosphorylation site [posttranslational modification]
402626009198	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626009199	ATP binding site [chemical binding]; other site
402626009200	Mg2+ binding site [ion binding]; other site
402626009201	G-X-G motif; other site
402626009202	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
402626009203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626009204	active site
402626009205	phosphorylation site [posttranslational modification]
402626009206	intermolecular recognition site; other site
402626009207	dimerization interface [polypeptide binding]; other site
402626009208	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626009209	DNA binding residues [nucleotide binding]
402626009210	dimerization interface [polypeptide binding]; other site
402626009211	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
402626009212	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
402626009213	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
402626009214	homodimer interface [polypeptide binding]; other site
402626009215	NADP binding site [chemical binding]; other site
402626009216	substrate binding site [chemical binding]; other site
402626009217	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
402626009218	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
402626009219	active site
402626009220	Zn binding site [ion binding]; other site
402626009221	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
402626009222	putative catalytic site [active]
402626009223	putative phosphate binding site [ion binding]; other site
402626009224	active site
402626009225	metal binding site A [ion binding]; metal-binding site
402626009226	DNA binding site [nucleotide binding]
402626009227	putative AP binding site [nucleotide binding]; other site
402626009228	putative metal binding site B [ion binding]; other site
402626009229	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
402626009230	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
402626009231	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
402626009232	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
402626009233	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
402626009234	putative substrate binding pocket [chemical binding]; other site
402626009235	trimer interface [polypeptide binding]; other site
402626009236	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
402626009237	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
402626009238	putative active site [active]
402626009239	putative metal binding site [ion binding]; other site
402626009240	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
402626009241	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
402626009242	NAD binding site [chemical binding]; other site
402626009243	catalytic residues [active]
402626009244	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
402626009245	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
402626009246	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
402626009247	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
402626009248	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
402626009249	amino acid transporter; Region: 2A0306; TIGR00909
402626009250	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
402626009251	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
402626009252	active site
402626009253	DNA polymerase IV; Validated; Region: PRK02406
402626009254	DNA binding site [nucleotide binding]
402626009255	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
402626009256	active site
402626009257	catalytic residues [active]
402626009258	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
402626009259	Cupin; Region: Cupin_6; pfam12852
402626009260	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
402626009261	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626009262	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
402626009263	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
402626009264	DNA binding residues [nucleotide binding]
402626009265	putative dimer interface [polypeptide binding]; other site
402626009266	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
402626009267	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
402626009268	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
402626009269	DNA binding residues [nucleotide binding]
402626009270	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
402626009271	IHF dimer interface [polypeptide binding]; other site
402626009272	IHF - DNA interface [nucleotide binding]; other site
402626009273	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
402626009274	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
402626009275	putative tRNA-binding site [nucleotide binding]; other site
402626009276	B3/4 domain; Region: B3_4; pfam03483
402626009277	tRNA synthetase B5 domain; Region: B5; smart00874
402626009278	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
402626009279	dimer interface [polypeptide binding]; other site
402626009280	motif 1; other site
402626009281	motif 3; other site
402626009282	motif 2; other site
402626009283	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
402626009284	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
402626009285	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
402626009286	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
402626009287	dimer interface [polypeptide binding]; other site
402626009288	motif 1; other site
402626009289	active site
402626009290	motif 2; other site
402626009291	motif 3; other site
402626009292	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
402626009293	23S rRNA binding site [nucleotide binding]; other site
402626009294	L21 binding site [polypeptide binding]; other site
402626009295	L13 binding site [polypeptide binding]; other site
402626009296	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
402626009297	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
402626009298	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
402626009299	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
402626009300	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
402626009301	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
402626009302	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
402626009303	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
402626009304	active site
402626009305	dimer interface [polypeptide binding]; other site
402626009306	motif 1; other site
402626009307	motif 2; other site
402626009308	motif 3; other site
402626009309	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
402626009310	anticodon binding site; other site
402626009311	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
402626009312	HD domain; Region: HD_4; pfam13328
402626009313	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
402626009314	synthetase active site [active]
402626009315	NTP binding site [chemical binding]; other site
402626009316	metal binding site [ion binding]; metal-binding site
402626009317	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
402626009318	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
402626009319	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
402626009320	homotrimer interaction site [polypeptide binding]; other site
402626009321	putative active site [active]
402626009322	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
402626009323	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
402626009324	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
402626009325	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
402626009326	NAD binding site [chemical binding]; other site
402626009327	homotetramer interface [polypeptide binding]; other site
402626009328	homodimer interface [polypeptide binding]; other site
402626009329	substrate binding site [chemical binding]; other site
402626009330	active site
402626009331	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
402626009332	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
402626009333	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626009334	PAS domain; Region: PAS_9; pfam13426
402626009335	putative active site [active]
402626009336	heme pocket [chemical binding]; other site
402626009337	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626009338	DNA binding residues [nucleotide binding]
402626009339	dimerization interface [polypeptide binding]; other site
402626009340	short chain dehydrogenase; Provisional; Region: PRK06949
402626009341	classical (c) SDRs; Region: SDR_c; cd05233
402626009342	NAD(P) binding site [chemical binding]; other site
402626009343	active site
402626009344	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
402626009345	hydroxyglutarate oxidase; Provisional; Region: PRK11728
402626009346	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
402626009347	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
402626009348	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
402626009349	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
402626009350	Tetramer interface [polypeptide binding]; other site
402626009351	active site
402626009352	FMN-binding site [chemical binding]; other site
402626009353	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
402626009354	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
402626009355	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626009356	putative substrate translocation pore; other site
402626009357	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
402626009358	putative acyl-acceptor binding pocket; other site
402626009359	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625
402626009360	FOG: CBS domain [General function prediction only]; Region: COG0517
402626009361	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
402626009362	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
402626009363	homodimer interface [polypeptide binding]; other site
402626009364	substrate-cofactor binding pocket; other site
402626009365	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626009366	catalytic residue [active]
402626009367	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
402626009368	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
402626009369	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
402626009370	Predicted membrane protein [Function unknown]; Region: COG4323
402626009371	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
402626009372	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
402626009373	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
402626009374	Predicted membrane protein [Function unknown]; Region: COG3308
402626009375	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
402626009376	FAD binding domain; Region: FAD_binding_4; pfam01565
402626009377	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
402626009378	ligand binding site [chemical binding]; other site
402626009379	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
402626009380	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626009381	putative DNA binding site [nucleotide binding]; other site
402626009382	putative Zn2+ binding site [ion binding]; other site
402626009383	AsnC family; Region: AsnC_trans_reg; pfam01037
402626009384	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
402626009385	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
402626009386	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
402626009387	catalytic residue [active]
402626009388	Putative phosphatase (DUF442); Region: DUF442; cl17385
402626009389	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
402626009390	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626009391	putative DNA binding site [nucleotide binding]; other site
402626009392	putative Zn2+ binding site [ion binding]; other site
402626009393	AsnC family; Region: AsnC_trans_reg; pfam01037
402626009394	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
402626009395	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
402626009396	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626009397	catalytic residue [active]
402626009398	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
402626009399	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
402626009400	active site
402626009401	catalytic tetrad [active]
402626009402	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
402626009403	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
402626009404	putative active site [active]
402626009405	putative FMN binding site [chemical binding]; other site
402626009406	putative substrate binding site [chemical binding]; other site
402626009407	putative catalytic residue [active]
402626009408	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
402626009409	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
402626009410	DNA binding residues [nucleotide binding]
402626009411	Lysine efflux permease [General function prediction only]; Region: COG1279
402626009412	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
402626009413	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626009414	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626009415	dimerization interface [polypeptide binding]; other site
402626009416	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
402626009417	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626009418	dimerization interface [polypeptide binding]; other site
402626009419	putative DNA binding site [nucleotide binding]; other site
402626009420	putative Zn2+ binding site [ion binding]; other site
402626009421	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
402626009422	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
402626009423	catalytic core [active]
402626009424	Putative hemolysin [General function prediction only]; Region: COG3176
402626009425	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
402626009426	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
402626009427	polyphosphate kinase; Provisional; Region: PRK05443
402626009428	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
402626009429	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
402626009430	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
402626009431	putative domain interface [polypeptide binding]; other site
402626009432	putative active site [active]
402626009433	catalytic site [active]
402626009434	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
402626009435	putative domain interface [polypeptide binding]; other site
402626009436	putative active site [active]
402626009437	catalytic site [active]
402626009438	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
402626009439	PAS domain; Region: PAS; smart00091
402626009440	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626009441	dimer interface [polypeptide binding]; other site
402626009442	phosphorylation site [posttranslational modification]
402626009443	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626009444	ATP binding site [chemical binding]; other site
402626009445	Mg2+ binding site [ion binding]; other site
402626009446	G-X-G motif; other site
402626009447	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
402626009448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626009449	active site
402626009450	phosphorylation site [posttranslational modification]
402626009451	intermolecular recognition site; other site
402626009452	dimerization interface [polypeptide binding]; other site
402626009453	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626009454	DNA binding site [nucleotide binding]
402626009455	transcriptional regulator PhoU; Provisional; Region: PRK11115
402626009456	PhoU domain; Region: PhoU; pfam01895
402626009457	PhoU domain; Region: PhoU; pfam01895
402626009458	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
402626009459	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
402626009460	Walker A/P-loop; other site
402626009461	ATP binding site [chemical binding]; other site
402626009462	Q-loop/lid; other site
402626009463	ABC transporter signature motif; other site
402626009464	Walker B; other site
402626009465	D-loop; other site
402626009466	H-loop/switch region; other site
402626009467	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
402626009468	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626009469	dimer interface [polypeptide binding]; other site
402626009470	conserved gate region; other site
402626009471	putative PBP binding loops; other site
402626009472	ABC-ATPase subunit interface; other site
402626009473	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
402626009474	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626009475	dimer interface [polypeptide binding]; other site
402626009476	conserved gate region; other site
402626009477	putative PBP binding loops; other site
402626009478	ABC-ATPase subunit interface; other site
402626009479	PBP superfamily domain; Region: PBP_like_2; cl17296
402626009480	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
402626009481	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
402626009482	active site
402626009483	substrate binding site [chemical binding]; other site
402626009484	metal binding site [ion binding]; metal-binding site
402626009485	dihydropteroate synthase; Region: DHPS; TIGR01496
402626009486	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
402626009487	substrate binding pocket [chemical binding]; other site
402626009488	dimer interface [polypeptide binding]; other site
402626009489	inhibitor binding site; inhibition site
402626009490	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
402626009491	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626009492	Walker A motif; other site
402626009493	ATP binding site [chemical binding]; other site
402626009494	Walker B motif; other site
402626009495	arginine finger; other site
402626009496	Peptidase family M41; Region: Peptidase_M41; pfam01434
402626009497	FtsJ-like methyltransferase; Region: FtsJ; cl17430
402626009498	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
402626009499	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
402626009500	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
402626009501	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
402626009502	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
402626009503	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
402626009504	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
402626009505	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
402626009506	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
402626009507	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
402626009508	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
402626009509	ATP-grasp domain; Region: ATP-grasp_4; cl17255
402626009510	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
402626009511	IMP binding site; other site
402626009512	dimer interface [polypeptide binding]; other site
402626009513	interdomain contacts; other site
402626009514	partial ornithine binding site; other site
402626009515	leucine export protein LeuE; Provisional; Region: PRK10958
402626009516	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
402626009517	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
402626009518	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
402626009519	catalytic site [active]
402626009520	subunit interface [polypeptide binding]; other site
402626009521	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
402626009522	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
402626009523	acyl-activating enzyme (AAE) consensus motif; other site
402626009524	AMP binding site [chemical binding]; other site
402626009525	active site
402626009526	CoA binding site [chemical binding]; other site
402626009527	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
402626009528	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
402626009529	N-acetyl-D-glucosamine binding site [chemical binding]; other site
402626009530	catalytic residue [active]
402626009531	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
402626009532	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
402626009533	Methyltransferase domain; Region: Methyltransf_11; pfam08241
402626009534	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
402626009535	RNA/DNA hybrid binding site [nucleotide binding]; other site
402626009536	active site
402626009537	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
402626009538	active site
402626009539	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
402626009540	catalytic residues [active]
402626009541	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
402626009542	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
402626009543	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626009544	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626009545	DNA binding residues [nucleotide binding]
402626009546	dimerization interface [polypeptide binding]; other site
402626009547	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
402626009548	SpoVR family protein; Provisional; Region: PRK11767
402626009549	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
402626009550	hypothetical protein; Provisional; Region: PRK05325
402626009551	PrkA family serine protein kinase; Provisional; Region: PRK15455
402626009552	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
402626009553	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626009554	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626009555	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
402626009556	dimerization interface [polypeptide binding]; other site
402626009557	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
402626009558	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
402626009559	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
402626009560	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
402626009561	putative hydrophobic ligand binding site [chemical binding]; other site
402626009562	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
402626009563	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
402626009564	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
402626009565	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626009566	catalytic loop [active]
402626009567	iron binding site [ion binding]; other site
402626009568	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
402626009569	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
402626009570	AMP-binding enzyme; Region: AMP-binding; pfam00501
402626009571	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
402626009572	acyl-activating enzyme (AAE) consensus motif; other site
402626009573	acyl-activating enzyme (AAE) consensus motif; other site
402626009574	active site
402626009575	AMP binding site [chemical binding]; other site
402626009576	CoA binding site [chemical binding]; other site
402626009577	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
402626009578	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
402626009579	trimer interface [polypeptide binding]; other site
402626009580	putative metal binding site [ion binding]; other site
402626009581	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626009582	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626009583	eyelet of channel; other site
402626009584	trimer interface [polypeptide binding]; other site
402626009585	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
402626009586	CoA-transferase family III; Region: CoA_transf_3; pfam02515
402626009587	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
402626009588	active site
402626009589	catalytic residues [active]
402626009590	metal binding site [ion binding]; metal-binding site
402626009591	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626009592	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626009593	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
402626009594	putative dimerization interface [polypeptide binding]; other site
402626009595	benzoate transport; Region: 2A0115; TIGR00895
402626009596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626009597	putative substrate translocation pore; other site
402626009598	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626009599	putative substrate translocation pore; other site
402626009600	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
402626009601	Transposase; Region: HTH_Tnp_1; pfam01527
402626009602	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
402626009603	integrase; Provisional; Region: PRK09692
402626009604	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
402626009605	active site
402626009606	Int/Topo IB signature motif; other site
402626009607	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
402626009608	active site
402626009609	catalytic site [active]
402626009610	substrate binding site [chemical binding]; other site
402626009611	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
402626009612	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
402626009613	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
402626009614	putative active site [active]
402626009615	putative substrate binding site [chemical binding]; other site
402626009616	putative cosubstrate binding site; other site
402626009617	catalytic site [active]
402626009618	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
402626009619	nudix motif; other site
402626009620	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
402626009621	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
402626009622	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
402626009623	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
402626009624	putative ligand binding site [chemical binding]; other site
402626009625	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626009626	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626009627	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626009628	dimerization interface [polypeptide binding]; other site
402626009629	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
402626009630	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
402626009631	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
402626009632	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626009633	dimer interface [polypeptide binding]; other site
402626009634	conserved gate region; other site
402626009635	putative PBP binding loops; other site
402626009636	ABC-ATPase subunit interface; other site
402626009637	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
402626009638	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626009639	dimer interface [polypeptide binding]; other site
402626009640	conserved gate region; other site
402626009641	putative PBP binding loops; other site
402626009642	ABC-ATPase subunit interface; other site
402626009643	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
402626009644	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
402626009645	Walker A/P-loop; other site
402626009646	ATP binding site [chemical binding]; other site
402626009647	Q-loop/lid; other site
402626009648	ABC transporter signature motif; other site
402626009649	Walker B; other site
402626009650	D-loop; other site
402626009651	H-loop/switch region; other site
402626009652	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
402626009653	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
402626009654	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
402626009655	Walker A/P-loop; other site
402626009656	ATP binding site [chemical binding]; other site
402626009657	Q-loop/lid; other site
402626009658	ABC transporter signature motif; other site
402626009659	Walker B; other site
402626009660	D-loop; other site
402626009661	H-loop/switch region; other site
402626009662	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
402626009663	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
402626009664	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
402626009665	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
402626009666	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
402626009667	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
402626009668	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
402626009669	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
402626009670	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
402626009671	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
402626009672	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
402626009673	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
402626009674	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
402626009675	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
402626009676	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
402626009677	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626009678	catalytic loop [active]
402626009679	iron binding site [ion binding]; other site
402626009680	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
402626009681	Predicted acyl esterases [General function prediction only]; Region: COG2936
402626009682	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
402626009683	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
402626009684	CHASE3 domain; Region: CHASE3; cl05000
402626009685	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
402626009686	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
402626009687	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626009688	dimerization interface [polypeptide binding]; other site
402626009689	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626009690	dimer interface [polypeptide binding]; other site
402626009691	putative CheW interface [polypeptide binding]; other site
402626009692	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
402626009693	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
402626009694	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
402626009695	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
402626009696	acetyl-CoA synthetase; Provisional; Region: PRK00174
402626009697	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
402626009698	active site
402626009699	CoA binding site [chemical binding]; other site
402626009700	acyl-activating enzyme (AAE) consensus motif; other site
402626009701	AMP binding site [chemical binding]; other site
402626009702	acetate binding site [chemical binding]; other site
402626009703	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
402626009704	EamA-like transporter family; Region: EamA; pfam00892
402626009705	EamA-like transporter family; Region: EamA; pfam00892
402626009706	hypothetical protein; Provisional; Region: PRK05208
402626009707	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
402626009708	Fumarase C-terminus; Region: Fumerase_C; pfam05683
402626009709	glutamate racemase; Provisional; Region: PRK00865
402626009710	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
402626009711	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
402626009712	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
402626009713	ATP cone domain; Region: ATP-cone; pfam03477
402626009714	Class III ribonucleotide reductase; Region: RNR_III; cd01675
402626009715	effector binding site; other site
402626009716	active site
402626009717	Zn binding site [ion binding]; other site
402626009718	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
402626009719	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
402626009720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626009721	FeS/SAM binding site; other site
402626009722	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
402626009723	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
402626009724	ligand binding site [chemical binding]; other site
402626009725	flexible hinge region; other site
402626009726	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
402626009727	putative switch regulator; other site
402626009728	non-specific DNA interactions [nucleotide binding]; other site
402626009729	DNA binding site [nucleotide binding]
402626009730	sequence specific DNA binding site [nucleotide binding]; other site
402626009731	putative cAMP binding site [chemical binding]; other site
402626009732	Uncharacterized conserved protein [Function unknown]; Region: COG4273
402626009733	SCP-2 sterol transfer family; Region: SCP2; cl01225
402626009734	putative protease; Provisional; Region: PRK15447
402626009735	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
402626009736	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
402626009737	Peptidase family U32; Region: Peptidase_U32; pfam01136
402626009738	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626009739	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
402626009740	Walker A motif; other site
402626009741	ATP binding site [chemical binding]; other site
402626009742	Walker B motif; other site
402626009743	arginine finger; other site
402626009744	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
402626009745	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626009746	Walker A motif; other site
402626009747	ATP binding site [chemical binding]; other site
402626009748	Walker B motif; other site
402626009749	arginine finger; other site
402626009750	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
402626009751	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
402626009752	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
402626009753	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
402626009754	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
402626009755	Hemin uptake protein hemP; Region: hemP; pfam10636
402626009756	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
402626009757	phasin family protein; Region: phasin; TIGR01841
402626009758	PRC-barrel domain; Region: PRC; pfam05239
402626009759	nodulation ABC transporter NodI; Provisional; Region: PRK13537
402626009760	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
402626009761	Walker A/P-loop; other site
402626009762	ATP binding site [chemical binding]; other site
402626009763	Q-loop/lid; other site
402626009764	ABC transporter signature motif; other site
402626009765	Walker B; other site
402626009766	D-loop; other site
402626009767	H-loop/switch region; other site
402626009768	ABC-2 type transporter; Region: ABC2_membrane; cl17235
402626009769	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
402626009770	amidophosphoribosyltransferase; Provisional; Region: PRK09246
402626009771	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
402626009772	active site
402626009773	tetramer interface [polypeptide binding]; other site
402626009774	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
402626009775	active site
402626009776	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
402626009777	Colicin V production protein; Region: Colicin_V; pfam02674
402626009778	Sporulation related domain; Region: SPOR; pfam05036
402626009779	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
402626009780	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
402626009781	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
402626009782	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
402626009783	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
402626009784	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
402626009785	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
402626009786	substrate binding site [chemical binding]; other site
402626009787	active site
402626009788	catalytic residues [active]
402626009789	heterodimer interface [polypeptide binding]; other site
402626009790	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
402626009791	DNA methylase; Region: N6_N4_Mtase; pfam01555
402626009792	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
402626009793	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
402626009794	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626009795	catalytic residue [active]
402626009796	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
402626009797	active site
402626009798	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
402626009799	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
402626009800	dimerization interface 3.5A [polypeptide binding]; other site
402626009801	active site
402626009802	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
402626009803	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
402626009804	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
402626009805	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
402626009806	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
402626009807	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
402626009808	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
402626009809	tartrate dehydrogenase; Provisional; Region: PRK08194
402626009810	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
402626009811	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
402626009812	substrate binding site [chemical binding]; other site
402626009813	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
402626009814	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
402626009815	substrate binding site [chemical binding]; other site
402626009816	ligand binding site [chemical binding]; other site
402626009817	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
402626009818	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
402626009819	dimer interface [polypeptide binding]; other site
402626009820	active site
402626009821	citrylCoA binding site [chemical binding]; other site
402626009822	NADH binding [chemical binding]; other site
402626009823	cationic pore residues; other site
402626009824	oxalacetate/citrate binding site [chemical binding]; other site
402626009825	coenzyme A binding site [chemical binding]; other site
402626009826	catalytic triad [active]
402626009827	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
402626009828	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
402626009829	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
402626009830	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
402626009831	L-aspartate oxidase; Provisional; Region: PRK06175
402626009832	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
402626009833	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
402626009834	SdhC subunit interface [polypeptide binding]; other site
402626009835	proximal heme binding site [chemical binding]; other site
402626009836	cardiolipin binding site; other site
402626009837	Iron-sulfur protein interface; other site
402626009838	proximal quinone binding site [chemical binding]; other site
402626009839	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
402626009840	Iron-sulfur protein interface; other site
402626009841	proximal quinone binding site [chemical binding]; other site
402626009842	SdhD (CybS) interface [polypeptide binding]; other site
402626009843	proximal heme binding site [chemical binding]; other site
402626009844	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
402626009845	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626009846	DNA-binding site [nucleotide binding]; DNA binding site
402626009847	UTRA domain; Region: UTRA; pfam07702
402626009848	malate dehydrogenase; Provisional; Region: PRK05442
402626009849	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
402626009850	NAD(P) binding site [chemical binding]; other site
402626009851	dimer interface [polypeptide binding]; other site
402626009852	malate binding site [chemical binding]; other site
402626009853	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
402626009854	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
402626009855	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
402626009856	tetramer interface [polypeptide binding]; other site
402626009857	active site
402626009858	Mg2+/Mn2+ binding site [ion binding]; other site
402626009859	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
402626009860	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
402626009861	aconitate hydratase; Provisional; Region: acnA; PRK12881
402626009862	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
402626009863	substrate binding site [chemical binding]; other site
402626009864	ligand binding site [chemical binding]; other site
402626009865	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
402626009866	substrate binding site [chemical binding]; other site
402626009867	Protein of unknown function (DUF2863); Region: DUF2863; pfam11062
402626009868	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
402626009869	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
402626009870	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
402626009871	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
402626009872	putative active site [active]
402626009873	Zn binding site [ion binding]; other site
402626009874	hypothetical protein; Validated; Region: PRK02101
402626009875	PIN domain; Region: PIN_3; pfam13470
402626009876	methionine aminotransferase; Validated; Region: PRK09082
402626009877	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626009878	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626009879	homodimer interface [polypeptide binding]; other site
402626009880	catalytic residue [active]
402626009881	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
402626009882	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
402626009883	C-terminal domain interface [polypeptide binding]; other site
402626009884	GSH binding site (G-site) [chemical binding]; other site
402626009885	dimer interface [polypeptide binding]; other site
402626009886	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
402626009887	putative N-terminal domain interface [polypeptide binding]; other site
402626009888	putative dimer interface [polypeptide binding]; other site
402626009889	putative substrate binding pocket (H-site) [chemical binding]; other site
402626009890	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
402626009891	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
402626009892	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
402626009893	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
402626009894	enoyl-CoA hydratase; Provisional; Region: PRK07511
402626009895	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626009896	substrate binding site [chemical binding]; other site
402626009897	oxyanion hole (OAH) forming residues; other site
402626009898	trimer interface [polypeptide binding]; other site
402626009899	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
402626009900	catalytic core [active]
402626009901	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
402626009902	putative active site [active]
402626009903	putative substrate binding site [chemical binding]; other site
402626009904	ATP binding site [chemical binding]; other site
402626009905	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
402626009906	dimer interface [polypeptide binding]; other site
402626009907	putative metal binding site [ion binding]; other site
402626009908	short chain dehydrogenase; Provisional; Region: PRK06500
402626009909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626009910	NAD(P) binding site [chemical binding]; other site
402626009911	active site
402626009912	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626009913	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626009914	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626009915	putative effector binding pocket; other site
402626009916	dimerization interface [polypeptide binding]; other site
402626009917	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
402626009918	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626009919	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
402626009920	substrate binding pocket [chemical binding]; other site
402626009921	dimerization interface [polypeptide binding]; other site
402626009922	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
402626009923	CoenzymeA binding site [chemical binding]; other site
402626009924	subunit interaction site [polypeptide binding]; other site
402626009925	PHB binding site; other site
402626009926	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626009927	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626009928	active site
402626009929	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
402626009930	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
402626009931	C-terminal domain interface [polypeptide binding]; other site
402626009932	GSH binding site (G-site) [chemical binding]; other site
402626009933	dimer interface [polypeptide binding]; other site
402626009934	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
402626009935	N-terminal domain interface [polypeptide binding]; other site
402626009936	putative dimer interface [polypeptide binding]; other site
402626009937	active site
402626009938	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
402626009939	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
402626009940	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
402626009941	UreF; Region: UreF; pfam01730
402626009942	urease accessory protein UreE; Provisional; Region: ureE; PRK13263
402626009943	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
402626009944	dimer interface [polypeptide binding]; other site
402626009945	catalytic residues [active]
402626009946	urease subunit alpha; Reviewed; Region: ureC; PRK13207
402626009947	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
402626009948	subunit interactions [polypeptide binding]; other site
402626009949	active site
402626009950	flap region; other site
402626009951	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
402626009952	gamma-beta subunit interface [polypeptide binding]; other site
402626009953	alpha-beta subunit interface [polypeptide binding]; other site
402626009954	Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370
402626009955	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
402626009956	alpha-gamma subunit interface [polypeptide binding]; other site
402626009957	beta-gamma subunit interface [polypeptide binding]; other site
402626009958	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
402626009959	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
402626009960	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
402626009961	Walker A/P-loop; other site
402626009962	ATP binding site [chemical binding]; other site
402626009963	Q-loop/lid; other site
402626009964	ABC transporter signature motif; other site
402626009965	Walker B; other site
402626009966	D-loop; other site
402626009967	H-loop/switch region; other site
402626009968	Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674
402626009969	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
402626009970	Walker A/P-loop; other site
402626009971	ATP binding site [chemical binding]; other site
402626009972	Q-loop/lid; other site
402626009973	ABC transporter signature motif; other site
402626009974	Walker B; other site
402626009975	D-loop; other site
402626009976	H-loop/switch region; other site
402626009977	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
402626009978	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
402626009979	TM-ABC transporter signature motif; other site
402626009980	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
402626009981	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626009982	TM-ABC transporter signature motif; other site
402626009983	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
402626009984	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
402626009985	putative ligand binding site [chemical binding]; other site
402626009986	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
402626009987	putative active site [active]
402626009988	putative catalytic site [active]
402626009989	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
402626009990	putative active site [active]
402626009991	putative catalytic site [active]
402626009992	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
402626009993	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
402626009994	active site
402626009995	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
402626009996	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
402626009997	FAD binding site [chemical binding]; other site
402626009998	substrate binding site [chemical binding]; other site
402626009999	catalytic base [active]
402626010000	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
402626010001	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
402626010002	dimer interface [polypeptide binding]; other site
402626010003	ADP-ribose binding site [chemical binding]; other site
402626010004	active site
402626010005	nudix motif; other site
402626010006	metal binding site [ion binding]; metal-binding site
402626010007	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
402626010008	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
402626010009	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
402626010010	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
402626010011	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
402626010012	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
402626010013	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
402626010014	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
402626010015	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
402626010016	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
402626010017	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
402626010018	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
402626010019	4Fe-4S binding domain; Region: Fer4; cl02805
402626010020	4Fe-4S binding domain; Region: Fer4; pfam00037
402626010021	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
402626010022	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
402626010023	NADH dehydrogenase subunit G; Validated; Region: PRK09129
402626010024	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626010025	catalytic loop [active]
402626010026	iron binding site [ion binding]; other site
402626010027	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
402626010028	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
402626010029	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
402626010030	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
402626010031	SLBB domain; Region: SLBB; pfam10531
402626010032	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
402626010033	NADH dehydrogenase subunit E; Validated; Region: PRK07539
402626010034	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
402626010035	putative dimer interface [polypeptide binding]; other site
402626010036	[2Fe-2S] cluster binding site [ion binding]; other site
402626010037	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
402626010038	NADH dehydrogenase subunit D; Validated; Region: PRK06075
402626010039	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
402626010040	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
402626010041	NADH dehydrogenase subunit B; Validated; Region: PRK06411
402626010042	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
402626010043	Preprotein translocase SecG subunit; Region: SecG; pfam03840
402626010044	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
402626010045	triosephosphate isomerase; Provisional; Region: PRK14567
402626010046	substrate binding site [chemical binding]; other site
402626010047	dimer interface [polypeptide binding]; other site
402626010048	catalytic triad [active]
402626010049	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
402626010050	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
402626010051	NAD(P) binding site [chemical binding]; other site
402626010052	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
402626010053	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
402626010054	RNase E interface [polypeptide binding]; other site
402626010055	trimer interface [polypeptide binding]; other site
402626010056	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
402626010057	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
402626010058	RNase E interface [polypeptide binding]; other site
402626010059	trimer interface [polypeptide binding]; other site
402626010060	active site
402626010061	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
402626010062	putative nucleic acid binding region [nucleotide binding]; other site
402626010063	G-X-X-G motif; other site
402626010064	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
402626010065	RNA binding site [nucleotide binding]; other site
402626010066	domain interface; other site
402626010067	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
402626010068	16S/18S rRNA binding site [nucleotide binding]; other site
402626010069	S13e-L30e interaction site [polypeptide binding]; other site
402626010070	25S rRNA binding site [nucleotide binding]; other site
402626010071	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
402626010072	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
402626010073	putative ligand binding site [chemical binding]; other site
402626010074	2-isopropylmalate synthase; Validated; Region: PRK00915
402626010075	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
402626010076	active site
402626010077	catalytic residues [active]
402626010078	metal binding site [ion binding]; metal-binding site
402626010079	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
402626010080	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
402626010081	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
402626010082	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
402626010083	ketol-acid reductoisomerase; Provisional; Region: PRK05479
402626010084	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
402626010085	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
402626010086	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
402626010087	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
402626010088	putative valine binding site [chemical binding]; other site
402626010089	dimer interface [polypeptide binding]; other site
402626010090	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
402626010091	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
402626010092	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
402626010093	PYR/PP interface [polypeptide binding]; other site
402626010094	dimer interface [polypeptide binding]; other site
402626010095	TPP binding site [chemical binding]; other site
402626010096	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
402626010097	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
402626010098	TPP-binding site [chemical binding]; other site
402626010099	dimer interface [polypeptide binding]; other site
402626010100	RNA polymerase factor sigma-70; Validated; Region: PRK09047
402626010101	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
402626010102	DNA binding residues [nucleotide binding]
402626010103	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
402626010104	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
402626010105	RDD family; Region: RDD; pfam06271
402626010106	PGAP1-like protein; Region: PGAP1; pfam07819
402626010107	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
402626010108	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
402626010109	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
402626010110	putative active site [active]
402626010111	putative metal binding site [ion binding]; other site
402626010112	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
402626010113	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
402626010114	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
402626010115	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626010116	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626010117	Bacterial transcriptional repressor; Region: TetR; pfam13972
402626010118	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
402626010119	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
402626010120	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
402626010121	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
402626010122	apolar tunnel; other site
402626010123	heme binding site [chemical binding]; other site
402626010124	dimerization interface [polypeptide binding]; other site
402626010125	FtsX-like permease family; Region: FtsX; pfam02687
402626010126	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
402626010127	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626010128	Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910
402626010129	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
402626010130	PBP superfamily domain; Region: PBP_like_2; pfam12849
402626010131	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626010132	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626010133	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463
402626010134	putative substrate binding pocket [chemical binding]; other site
402626010135	putative dimerization interface [polypeptide binding]; other site
402626010136	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
402626010137	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626010138	catalytic loop [active]
402626010139	iron binding site [ion binding]; other site
402626010140	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
402626010141	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
402626010142	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
402626010143	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
402626010144	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
402626010145	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
402626010146	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
402626010147	XdhC Rossmann domain; Region: XdhC_C; pfam13478
402626010148	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
402626010149	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
402626010150	active site
402626010151	purine riboside binding site [chemical binding]; other site
402626010152	guanine deaminase; Provisional; Region: PRK09228
402626010153	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
402626010154	active site
402626010155	Predicted membrane protein [Function unknown]; Region: COG2119
402626010156	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
402626010157	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
402626010158	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
402626010159	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
402626010160	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
402626010161	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
402626010162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
402626010163	Predicted membrane protein [Function unknown]; Region: COG3748
402626010164	Protein of unknown function (DUF989); Region: DUF989; pfam06181
402626010165	Cytochrome c; Region: Cytochrom_C; pfam00034
402626010166	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
402626010167	active site
402626010168	homotetramer interface [polypeptide binding]; other site
402626010169	Transcriptional regulators [Transcription]; Region: GntR; COG1802
402626010170	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626010171	DNA-binding site [nucleotide binding]; DNA binding site
402626010172	FCD domain; Region: FCD; pfam07729
402626010173	xanthine permease; Region: pbuX; TIGR03173
402626010174	Sulfate transporter family; Region: Sulfate_transp; pfam00916
402626010175	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
402626010176	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
402626010177	active site
402626010178	putative substrate binding pocket [chemical binding]; other site
402626010179	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
402626010180	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
402626010181	active site
402626010182	catalytic site [active]
402626010183	tetramer interface [polypeptide binding]; other site
402626010184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
402626010185	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626010186	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626010187	eyelet of channel; other site
402626010188	trimer interface [polypeptide binding]; other site
402626010189	malic enzyme; Reviewed; Region: PRK12862
402626010190	Malic enzyme, N-terminal domain; Region: malic; pfam00390
402626010191	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
402626010192	putative NAD(P) binding site [chemical binding]; other site
402626010193	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
402626010194	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
402626010195	aminopeptidase N; Provisional; Region: pepN; PRK14015
402626010196	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
402626010197	active site
402626010198	Zn binding site [ion binding]; other site
402626010199	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
402626010200	AMP binding site [chemical binding]; other site
402626010201	metal binding site [ion binding]; metal-binding site
402626010202	active site
402626010203	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
402626010204	BON domain; Region: BON; pfam04972
402626010205	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
402626010206	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
402626010207	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
402626010208	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626010209	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
402626010210	dimerization interface [polypeptide binding]; other site
402626010211	substrate binding pocket [chemical binding]; other site
402626010212	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
402626010213	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
402626010214	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
402626010215	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
402626010216	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
402626010217	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
402626010218	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
402626010219	Zn2+ binding site [ion binding]; other site
402626010220	Mg2+ binding site [ion binding]; other site
402626010221	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
402626010222	synthetase active site [active]
402626010223	NTP binding site [chemical binding]; other site
402626010224	metal binding site [ion binding]; metal-binding site
402626010225	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
402626010226	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
402626010227	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
402626010228	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
402626010229	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
402626010230	catalytic site [active]
402626010231	G-X2-G-X-G-K; other site
402626010232	hypothetical protein; Provisional; Region: PRK11820
402626010233	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
402626010234	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
402626010235	Protein kinase domain; Region: Pkinase; pfam00069
402626010236	Catalytic domain of Protein Kinases; Region: PKc; cd00180
402626010237	active site
402626010238	ATP binding site [chemical binding]; other site
402626010239	substrate binding site [chemical binding]; other site
402626010240	activation loop (A-loop); other site
402626010241	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
402626010242	active site
402626010243	ribonuclease PH; Reviewed; Region: rph; PRK00173
402626010244	Ribonuclease PH; Region: RNase_PH_bact; cd11362
402626010245	hexamer interface [polypeptide binding]; other site
402626010246	active site
402626010247	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
402626010248	active site
402626010249	dimerization interface [polypeptide binding]; other site
402626010250	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
402626010251	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626010252	FeS/SAM binding site; other site
402626010253	HemN C-terminal domain; Region: HemN_C; pfam06969
402626010254	integrase; Provisional; Region: PRK09692
402626010255	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
402626010256	active site
402626010257	Int/Topo IB signature motif; other site
402626010258	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
402626010259	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
402626010260	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
402626010261	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
402626010262	HSP70 interaction site [polypeptide binding]; other site
402626010263	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
402626010264	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
402626010265	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
402626010266	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
402626010267	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
402626010268	Protein of unknown function (DUF968); Region: DUF968; pfam06147
402626010269	NinB protein; Region: NinB; pfam05772
402626010270	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
402626010271	RNA ligase; Region: RNA_ligase; pfam09414
402626010272	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
402626010273	replicative DNA helicase; Region: DnaB; TIGR00665
402626010274	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
402626010275	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
402626010276	Walker A motif; other site
402626010277	ATP binding site [chemical binding]; other site
402626010278	Walker B motif; other site
402626010279	DNA binding loops [nucleotide binding]
402626010280	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
402626010281	transcriptional repressor DicA; Reviewed; Region: PRK09706
402626010282	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
402626010283	non-specific DNA binding site [nucleotide binding]; other site
402626010284	salt bridge; other site
402626010285	sequence-specific DNA binding site [nucleotide binding]; other site
402626010286	Predicted transcriptional regulator [Transcription]; Region: COG2932
402626010287	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
402626010288	Catalytic site [active]
402626010289	TROVE domain; Region: TROVE; pfam05731
402626010290	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
402626010291	metal ion-dependent adhesion site (MIDAS); other site
402626010292	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
402626010293	active site
402626010294	KTSC domain; Region: KTSC; pfam13619
402626010295	ERF superfamily; Region: ERF; pfam04404
402626010296	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
402626010297	methyl-accepting protein IV; Provisional; Region: PRK09793
402626010298	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
402626010299	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
402626010300	putative active site [active]
402626010301	putative NTP binding site [chemical binding]; other site
402626010302	putative nucleic acid binding site [nucleotide binding]; other site
402626010303	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
402626010304	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
402626010305	substrate interaction site [chemical binding]; other site
402626010306	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
402626010307	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
402626010308	DNA methylase; Region: N6_N4_Mtase; cl17433
402626010309	DNA methylase; Region: N6_N4_Mtase; cl17433
402626010310	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
402626010311	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
402626010312	PAS domain S-box; Region: sensory_box; TIGR00229
402626010313	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626010314	putative active site [active]
402626010315	heme pocket [chemical binding]; other site
402626010316	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626010317	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626010318	DNA binding residues [nucleotide binding]
402626010319	dimerization interface [polypeptide binding]; other site
402626010320	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
402626010321	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
402626010322	putative substrate binding pocket [chemical binding]; other site
402626010323	AC domain interface; other site
402626010324	catalytic triad [active]
402626010325	AB domain interface; other site
402626010326	interchain disulfide; other site
402626010327	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
402626010328	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
402626010329	Predicted membrane protein [Function unknown]; Region: COG3817
402626010330	Protein of unknown function (DUF979); Region: DUF979; pfam06166
402626010331	Predicted membrane protein [Function unknown]; Region: COG3819
402626010332	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
402626010333	putative active site [active]
402626010334	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
402626010335	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
402626010336	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
402626010337	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626010338	putative substrate translocation pore; other site
402626010339	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626010340	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
402626010341	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
402626010342	Walker A/P-loop; other site
402626010343	ATP binding site [chemical binding]; other site
402626010344	Q-loop/lid; other site
402626010345	ABC transporter signature motif; other site
402626010346	Walker B; other site
402626010347	D-loop; other site
402626010348	H-loop/switch region; other site
402626010349	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
402626010350	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626010351	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
402626010352	TM-ABC transporter signature motif; other site
402626010353	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626010354	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
402626010355	TM-ABC transporter signature motif; other site
402626010356	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
402626010357	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
402626010358	putative ligand binding site [chemical binding]; other site
402626010359	Uncharacterized conserved protein [Function unknown]; Region: COG3339
402626010360	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
402626010361	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
402626010362	NADP binding site [chemical binding]; other site
402626010363	dimer interface [polypeptide binding]; other site
402626010364	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
402626010365	active site
402626010366	dimer interfaces [polypeptide binding]; other site
402626010367	catalytic residues [active]
402626010368	short chain dehydrogenase; Provisional; Region: PRK08339
402626010369	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
402626010370	putative NAD(P) binding site [chemical binding]; other site
402626010371	putative active site [active]
402626010372	EamA-like transporter family; Region: EamA; pfam00892
402626010373	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
402626010374	EamA-like transporter family; Region: EamA; pfam00892
402626010375	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
402626010376	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
402626010377	Na binding site [ion binding]; other site
402626010378	putative substrate binding site [chemical binding]; other site
402626010379	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
402626010380	active site
402626010381	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
402626010382	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626010383	Walker A motif; other site
402626010384	ATP binding site [chemical binding]; other site
402626010385	hypothetical protein; Validated; Region: PRK00110
402626010386	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
402626010387	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
402626010388	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
402626010389	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
402626010390	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
402626010391	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
402626010392	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
402626010393	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
402626010394	active site
402626010395	(T/H)XGH motif; other site
402626010396	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
402626010397	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
402626010398	Maf-like protein; Region: Maf; pfam02545
402626010399	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
402626010400	active site
402626010401	dimer interface [polypeptide binding]; other site
402626010402	ribonuclease G; Provisional; Region: PRK11712
402626010403	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
402626010404	homodimer interface [polypeptide binding]; other site
402626010405	oligonucleotide binding site [chemical binding]; other site
402626010406	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
402626010407	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
402626010408	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
402626010409	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
402626010410	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
402626010411	Walker A/P-loop; other site
402626010412	ATP binding site [chemical binding]; other site
402626010413	Q-loop/lid; other site
402626010414	ABC transporter signature motif; other site
402626010415	Walker B; other site
402626010416	D-loop; other site
402626010417	H-loop/switch region; other site
402626010418	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
402626010419	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
402626010420	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
402626010421	Substrate binding site; other site
402626010422	metal-binding site
402626010423	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
402626010424	putative metal binding site; other site
402626010425	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
402626010426	O-Antigen ligase; Region: Wzy_C; pfam04932
402626010427	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
402626010428	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
402626010429	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
402626010430	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
402626010431	putative active site [active]
402626010432	putative PHP Thumb interface [polypeptide binding]; other site
402626010433	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
402626010434	generic binding surface II; other site
402626010435	generic binding surface I; other site
402626010436	rhodanese superfamily protein; Provisional; Region: PRK05320
402626010437	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
402626010438	active site residue [active]
402626010439	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
402626010440	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
402626010441	Pirin-related protein [General function prediction only]; Region: COG1741
402626010442	Pirin; Region: Pirin; pfam02678
402626010443	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
402626010444	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626010445	The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431
402626010446	putative dimerization interface [polypeptide binding]; other site
402626010447	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
402626010448	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
402626010449	active site
402626010450	HIGH motif; other site
402626010451	nucleotide binding site [chemical binding]; other site
402626010452	active site
402626010453	KMSKS motif; other site
402626010454	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
402626010455	DEAD-like helicases superfamily; Region: DEXDc; smart00487
402626010456	ATP binding site [chemical binding]; other site
402626010457	Mg++ binding site [ion binding]; other site
402626010458	motif III; other site
402626010459	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
402626010460	nucleotide binding region [chemical binding]; other site
402626010461	ATP-binding site [chemical binding]; other site
402626010462	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
402626010463	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
402626010464	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
402626010465	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626010466	acyl-CoA synthetase; Validated; Region: PRK06178
402626010467	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
402626010468	acyl-activating enzyme (AAE) consensus motif; other site
402626010469	putative AMP binding site [chemical binding]; other site
402626010470	putative active site [active]
402626010471	putative CoA binding site [chemical binding]; other site
402626010472	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
402626010473	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
402626010474	ATP-grasp domain; Region: ATP-grasp_4; cl17255
402626010475	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
402626010476	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
402626010477	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
402626010478	carboxyltransferase (CT) interaction site; other site
402626010479	biotinylation site [posttranslational modification]; other site
402626010480	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
402626010481	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
402626010482	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
402626010483	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
402626010484	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
402626010485	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
402626010486	putative ligand binding site [chemical binding]; other site
402626010487	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
402626010488	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
402626010489	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
402626010490	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
402626010491	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
402626010492	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
402626010493	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
402626010494	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
402626010495	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
402626010496	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
402626010497	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
402626010498	DNA binding residues [nucleotide binding]
402626010499	DNA primase; Validated; Region: dnaG; PRK05667
402626010500	CHC2 zinc finger; Region: zf-CHC2; pfam01807
402626010501	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
402626010502	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
402626010503	active site
402626010504	metal binding site [ion binding]; metal-binding site
402626010505	interdomain interaction site; other site
402626010506	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
402626010507	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
402626010508	Yqey-like protein; Region: YqeY; pfam09424
402626010509	HI0933-like protein; Region: HI0933_like; pfam03486
402626010510	Protein of unknown function (DUF429); Region: DUF429; cl12046
402626010511	UGMP family protein; Validated; Region: PRK09604
402626010512	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
402626010513	putative GTP cyclohydrolase; Provisional; Region: PRK13674
402626010514	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
402626010515	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
402626010516	TPP-binding site; other site
402626010517	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
402626010518	PYR/PP interface [polypeptide binding]; other site
402626010519	dimer interface [polypeptide binding]; other site
402626010520	TPP binding site [chemical binding]; other site
402626010521	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
402626010522	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
402626010523	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
402626010524	substrate binding pocket [chemical binding]; other site
402626010525	chain length determination region; other site
402626010526	substrate-Mg2+ binding site; other site
402626010527	catalytic residues [active]
402626010528	aspartate-rich region 1; other site
402626010529	active site lid residues [active]
402626010530	aspartate-rich region 2; other site
402626010531	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
402626010532	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
402626010533	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
402626010534	[2Fe-2S] cluster binding site [ion binding]; other site
402626010535	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
402626010536	alpha subunit interface [polypeptide binding]; other site
402626010537	active site
402626010538	substrate binding site [chemical binding]; other site
402626010539	Fe binding site [ion binding]; other site
402626010540	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
402626010541	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
402626010542	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
402626010543	active site residue [active]
402626010544	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
402626010545	active site residue [active]
402626010546	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
402626010547	ZIP Zinc transporter; Region: Zip; pfam02535
402626010548	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
402626010549	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
402626010550	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
402626010551	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
402626010552	K+-transporting ATPase, c chain; Region: KdpC; cl00944
402626010553	DNA polymerase I; Provisional; Region: PRK05755
402626010554	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
402626010555	active site
402626010556	metal binding site 1 [ion binding]; metal-binding site
402626010557	putative 5' ssDNA interaction site; other site
402626010558	metal binding site 3; metal-binding site
402626010559	metal binding site 2 [ion binding]; metal-binding site
402626010560	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
402626010561	putative DNA binding site [nucleotide binding]; other site
402626010562	putative metal binding site [ion binding]; other site
402626010563	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
402626010564	active site
402626010565	catalytic site [active]
402626010566	substrate binding site [chemical binding]; other site
402626010567	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
402626010568	active site
402626010569	DNA binding site [nucleotide binding]
402626010570	catalytic site [active]
402626010571	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
402626010572	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
402626010573	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
402626010574	putative active site [active]
402626010575	putative substrate binding site [chemical binding]; other site
402626010576	ATP binding site [chemical binding]; other site
402626010577	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
402626010578	Part of AAA domain; Region: AAA_19; pfam13245
402626010579	Family description; Region: UvrD_C_2; pfam13538
402626010580	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
402626010581	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
402626010582	active site
402626010583	HIGH motif; other site
402626010584	nucleotide binding site [chemical binding]; other site
402626010585	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
402626010586	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
402626010587	active site
402626010588	KMSKS motif; other site
402626010589	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
402626010590	tRNA binding surface [nucleotide binding]; other site
402626010591	anticodon binding site; other site
402626010592	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
402626010593	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
402626010594	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
402626010595	active site
402626010596	tetramer interface; other site
402626010597	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
402626010598	rRNA binding site [nucleotide binding]; other site
402626010599	predicted 30S ribosome binding site; other site
402626010600	Predicted extracellular endo alpha-1,4 polygalactosaminidase or related polysaccharide hydrolase [Carbohydrate transport and metabolism]; Region: COG2342
402626010601	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
402626010602	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
402626010603	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626010604	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626010605	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
402626010606	substrate binding pocket [chemical binding]; other site
402626010607	dimerization interface [polypeptide binding]; other site
402626010608	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
402626010609	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
402626010610	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
402626010611	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
402626010612	Walker A/P-loop; other site
402626010613	ATP binding site [chemical binding]; other site
402626010614	Q-loop/lid; other site
402626010615	ABC transporter signature motif; other site
402626010616	Walker B; other site
402626010617	D-loop; other site
402626010618	H-loop/switch region; other site
402626010619	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
402626010620	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
402626010621	Walker A/P-loop; other site
402626010622	ATP binding site [chemical binding]; other site
402626010623	Q-loop/lid; other site
402626010624	ABC transporter signature motif; other site
402626010625	Walker B; other site
402626010626	D-loop; other site
402626010627	H-loop/switch region; other site
402626010628	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
402626010629	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
402626010630	TM-ABC transporter signature motif; other site
402626010631	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
402626010632	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626010633	TM-ABC transporter signature motif; other site
402626010634	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
402626010635	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
402626010636	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
402626010637	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
402626010638	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
402626010639	tetramer interface [polypeptide binding]; other site
402626010640	active site
402626010641	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
402626010642	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
402626010643	dimer interface [polypeptide binding]; other site
402626010644	active site
402626010645	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
402626010646	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
402626010647	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
402626010648	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
402626010649	Bacterial transcriptional regulator; Region: IclR; pfam01614
402626010650	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
402626010651	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626010652	substrate binding pocket [chemical binding]; other site
402626010653	membrane-bound complex binding site; other site
402626010654	hinge residues; other site
402626010655	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
402626010656	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626010657	dimer interface [polypeptide binding]; other site
402626010658	conserved gate region; other site
402626010659	putative PBP binding loops; other site
402626010660	ABC-ATPase subunit interface; other site
402626010661	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
402626010662	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626010663	dimer interface [polypeptide binding]; other site
402626010664	conserved gate region; other site
402626010665	putative PBP binding loops; other site
402626010666	ABC-ATPase subunit interface; other site
402626010667	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
402626010668	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
402626010669	Walker A/P-loop; other site
402626010670	ATP binding site [chemical binding]; other site
402626010671	Q-loop/lid; other site
402626010672	ABC transporter signature motif; other site
402626010673	Walker B; other site
402626010674	D-loop; other site
402626010675	H-loop/switch region; other site
402626010676	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
402626010677	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626010678	substrate binding pocket [chemical binding]; other site
402626010679	membrane-bound complex binding site; other site
402626010680	hinge residues; other site
402626010681	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
402626010682	Predicted membrane protein [Function unknown]; Region: COG4267
402626010683	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
402626010684	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
402626010685	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
402626010686	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
402626010687	GAF domain; Region: GAF_3; pfam13492
402626010688	Uncharacterized conserved protein [Function unknown]; Region: COG3868
402626010689	C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922
402626010690	putative active site [active]
402626010691	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
402626010692	Domain of unknown function DUF21; Region: DUF21; pfam01595
402626010693	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
402626010694	Transporter associated domain; Region: CorC_HlyC; smart01091
402626010695	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
402626010696	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
402626010697	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
402626010698	DNA binding residues [nucleotide binding]
402626010699	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
402626010700	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
402626010701	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
402626010702	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626010703	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
402626010704	substrate binding pocket [chemical binding]; other site
402626010705	membrane-bound complex binding site; other site
402626010706	hinge residues; other site
402626010707	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
402626010708	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
402626010709	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626010710	Walker A motif; other site
402626010711	ATP binding site [chemical binding]; other site
402626010712	Walker B motif; other site
402626010713	arginine finger; other site
402626010714	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626010715	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
402626010716	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
402626010717	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
402626010718	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
402626010719	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
402626010720	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
402626010721	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
402626010722	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626010723	FeS/SAM binding site; other site
402626010724	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
402626010725	Cytochrome c; Region: Cytochrom_C; cl11414
402626010726	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
402626010727	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
402626010728	dimer interface [polypeptide binding]; other site
402626010729	Trp docking motif [polypeptide binding]; other site
402626010730	active site
402626010731	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
402626010732	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
402626010733	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
402626010734	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
402626010735	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
402626010736	structural tetrad; other site
402626010737	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
402626010738	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
402626010739	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
402626010740	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
402626010741	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
402626010742	NAD(P) binding site [chemical binding]; other site
402626010743	catalytic residues [active]
402626010744	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
402626010745	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
402626010746	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
402626010747	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
402626010748	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626010749	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626010750	trimer interface [polypeptide binding]; other site
402626010751	eyelet of channel; other site
402626010752	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
402626010753	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
402626010754	putative acyl-acceptor binding pocket; other site
402626010755	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
402626010756	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
402626010757	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
402626010758	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
402626010759	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
402626010760	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
402626010761	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
402626010762	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
402626010763	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
402626010764	Hemerythrin-like domain; Region: Hr-like; cd12108
402626010765	Fe binding site [ion binding]; other site
402626010766	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
402626010767	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
402626010768	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
402626010769	ligand binding site [chemical binding]; other site
402626010770	flexible hinge region; other site
402626010771	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
402626010772	putative switch regulator; other site
402626010773	non-specific DNA interactions [nucleotide binding]; other site
402626010774	DNA binding site [nucleotide binding]
402626010775	sequence specific DNA binding site [nucleotide binding]; other site
402626010776	putative cAMP binding site [chemical binding]; other site
402626010777	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
402626010778	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
402626010779	Cupin domain; Region: Cupin_2; cl17218
402626010780	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
402626010781	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626010782	putative substrate translocation pore; other site
402626010783	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
402626010784	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
402626010785	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
402626010786	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
402626010787	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
402626010788	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
402626010789	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
402626010790	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
402626010791	[4Fe-4S] binding site [ion binding]; other site
402626010792	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
402626010793	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
402626010794	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
402626010795	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
402626010796	molybdopterin cofactor binding site; other site
402626010797	Integrase core domain; Region: rve; pfam00665
402626010798	Integrase core domain; Region: rve_3; pfam13683
402626010799	UPF0126 domain; Region: UPF0126; pfam03458
402626010800	Predicted membrane protein [Function unknown]; Region: COG2860
402626010801	UPF0126 domain; Region: UPF0126; pfam03458
402626010802	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
402626010803	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
402626010804	metal binding site [ion binding]; metal-binding site
402626010805	putative dimer interface [polypeptide binding]; other site
402626010806	Protein of unknown function (DUF2393); Region: DUF2393; pfam09624
402626010807	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
402626010808	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
402626010809	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
402626010810	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
402626010811	catalytic residues [active]
402626010812	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
402626010813	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
402626010814	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626010815	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
402626010816	dimer interface [polypeptide binding]; other site
402626010817	active site
402626010818	metal binding site [ion binding]; metal-binding site
402626010819	glutathione binding site [chemical binding]; other site
402626010820	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
402626010821	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
402626010822	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
402626010823	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
402626010824	Cytochrome c; Region: Cytochrom_C; cl11414
402626010825	Protein of unknown function (DUF2523); Region: DUF2523; pfam10734
402626010826	Zonular occludens toxin (Zot); Region: Zot; cl17485
402626010827	multiple promoter invertase; Provisional; Region: mpi; PRK13413
402626010828	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
402626010829	catalytic residues [active]
402626010830	catalytic nucleophile [active]
402626010831	Presynaptic Site I dimer interface [polypeptide binding]; other site
402626010832	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
402626010833	Synaptic Flat tetramer interface [polypeptide binding]; other site
402626010834	Synaptic Site I dimer interface [polypeptide binding]; other site
402626010835	DNA binding site [nucleotide binding]
402626010836	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
402626010837	DNA-binding interface [nucleotide binding]; DNA binding site
402626010838	seryl-tRNA synthetase; Provisional; Region: PRK05431
402626010839	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
402626010840	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
402626010841	dimer interface [polypeptide binding]; other site
402626010842	active site
402626010843	motif 1; other site
402626010844	motif 2; other site
402626010845	motif 3; other site
402626010846	recombination factor protein RarA; Reviewed; Region: PRK13342
402626010847	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626010848	Walker A motif; other site
402626010849	ATP binding site [chemical binding]; other site
402626010850	Walker B motif; other site
402626010851	arginine finger; other site
402626010852	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
402626010853	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626010854	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626010855	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
402626010856	dimerization interface [polypeptide binding]; other site
402626010857	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
402626010858	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
402626010859	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
402626010860	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
402626010861	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
402626010862	thioredoxin reductase; Provisional; Region: PRK10262
402626010863	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
402626010864	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
402626010865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
402626010866	Smr domain; Region: Smr; pfam01713
402626010867	Predicted membrane protein [Function unknown]; Region: COG2860
402626010868	UPF0126 domain; Region: UPF0126; pfam03458
402626010869	UPF0126 domain; Region: UPF0126; pfam03458
402626010870	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
402626010871	Nitrogen regulatory protein P-II; Region: P-II; smart00938
402626010872	Methyltransferase domain; Region: Methyltransf_23; pfam13489
402626010873	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626010874	S-adenosylmethionine binding site [chemical binding]; other site
402626010875	NAD synthetase; Provisional; Region: PRK13981
402626010876	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
402626010877	multimer interface [polypeptide binding]; other site
402626010878	active site
402626010879	catalytic triad [active]
402626010880	protein interface 1 [polypeptide binding]; other site
402626010881	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
402626010882	homodimer interface [polypeptide binding]; other site
402626010883	NAD binding pocket [chemical binding]; other site
402626010884	ATP binding pocket [chemical binding]; other site
402626010885	Mg binding site [ion binding]; other site
402626010886	active-site loop [active]
402626010887	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
402626010888	Protein of unknown function, DUF482; Region: DUF482; pfam04339
402626010889	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
402626010890	dimer interface [polypeptide binding]; other site
402626010891	substrate binding site [chemical binding]; other site
402626010892	metal binding sites [ion binding]; metal-binding site
402626010893	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
402626010894	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
402626010895	NAD(P) binding site [chemical binding]; other site
402626010896	catalytic residues [active]
402626010897	catalytic residues [active]
402626010898	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
402626010899	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
402626010900	putative NAD(P) binding site [chemical binding]; other site
402626010901	active site
402626010902	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
402626010903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626010904	putative substrate translocation pore; other site
402626010905	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
402626010906	HemY protein N-terminus; Region: HemY_N; pfam07219
402626010907	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
402626010908	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
402626010909	active site
402626010910	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
402626010911	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
402626010912	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
402626010913	domain interfaces; other site
402626010914	active site
402626010915	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
402626010916	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
402626010917	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
402626010918	dinuclear metal binding motif [ion binding]; other site
402626010919	RNA polymerase sigma factor; Provisional; Region: PRK12514
402626010920	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
402626010921	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
402626010922	DNA binding residues [nucleotide binding]
402626010923	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
402626010924	Anti-sigma-K factor rskA; Region: RskA; pfam10099
402626010925	argininosuccinate lyase; Provisional; Region: PRK00855
402626010926	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
402626010927	active sites [active]
402626010928	tetramer interface [polypeptide binding]; other site
402626010929	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
402626010930	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
402626010931	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
402626010932	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
402626010933	catalytic residue [active]
402626010934	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
402626010935	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
402626010936	trimer interface [polypeptide binding]; other site
402626010937	active site
402626010938	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
402626010939	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
402626010940	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
402626010941	E-class dimer interface [polypeptide binding]; other site
402626010942	P-class dimer interface [polypeptide binding]; other site
402626010943	active site
402626010944	Cu2+ binding site [ion binding]; other site
402626010945	Zn2+ binding site [ion binding]; other site
402626010946	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
402626010947	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
402626010948	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
402626010949	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
402626010950	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
402626010951	[4Fe-4S] binding site [ion binding]; other site
402626010952	molybdopterin cofactor binding site; other site
402626010953	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
402626010954	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
402626010955	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
402626010956	molybdopterin cofactor binding site; other site
402626010957	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
402626010958	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
402626010959	4Fe-4S binding domain; Region: Fer4; pfam00037
402626010960	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
402626010961	4Fe-4S binding domain; Region: Fer4; pfam00037
402626010962	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
402626010963	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
402626010964	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
402626010965	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
402626010966	antiporter inner membrane protein; Provisional; Region: PRK11670
402626010967	Domain of unknown function DUF59; Region: DUF59; pfam01883
402626010968	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
402626010969	Walker A motif; other site
402626010970	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
402626010971	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
402626010972	ligand binding site [chemical binding]; other site
402626010973	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
402626010974	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
402626010975	active site
402626010976	HIGH motif; other site
402626010977	KMSKS motif; other site
402626010978	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
402626010979	tRNA binding surface [nucleotide binding]; other site
402626010980	anticodon binding site; other site
402626010981	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
402626010982	dimer interface [polypeptide binding]; other site
402626010983	putative tRNA-binding site [nucleotide binding]; other site
402626010984	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
402626010985	Family of unknown function (DUF490); Region: DUF490; pfam04357
402626010986	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
402626010987	Surface antigen; Region: Bac_surface_Ag; pfam01103
402626010988	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
402626010989	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
402626010990	pantoate--beta-alanine ligase; Region: panC; TIGR00018
402626010991	Pantoate-beta-alanine ligase; Region: PanC; cd00560
402626010992	active site
402626010993	ATP-binding site [chemical binding]; other site
402626010994	pantoate-binding site; other site
402626010995	HXXH motif; other site
402626010996	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
402626010997	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
402626010998	active site
402626010999	Int/Topo IB signature motif; other site
402626011000	DNA binding site [nucleotide binding]
402626011001	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
402626011002	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
402626011003	WYL domain; Region: WYL; pfam13280
402626011004	Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457
402626011005	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
402626011006	ATP binding site [chemical binding]; other site
402626011007	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
402626011008	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
402626011009	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
402626011010	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
402626011011	Domain of unknown function (DUF932); Region: DUF932; pfam06067
402626011012	ParB-like nuclease domain; Region: ParBc; pfam02195
402626011013	Uncharacterized conserved protein [Function unknown]; Region: COG5489
402626011014	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
402626011015	non-specific DNA binding site [nucleotide binding]; other site
402626011016	salt bridge; other site
402626011017	sequence-specific DNA binding site [nucleotide binding]; other site
402626011018	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
402626011019	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
402626011020	Helix-turn-helix domain; Region: HTH_17; cl17695
402626011021	Replication initiator protein A; Region: RPA; pfam10134
402626011022	ParA-like protein; Provisional; Region: PHA02518
402626011023	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
402626011024	P-loop; other site
402626011025	Magnesium ion binding site [ion binding]; other site
402626011026	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
402626011027	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
402626011028	Type IV secretory pathway, protease TraF [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: TraF; COG4959
402626011029	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
402626011030	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
402626011031	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626011032	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
402626011033	NAD(P) binding site [chemical binding]; other site
402626011034	active site
402626011035	enoyl-CoA hydratase; Provisional; Region: PRK08138
402626011036	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626011037	substrate binding site [chemical binding]; other site
402626011038	oxyanion hole (OAH) forming residues; other site
402626011039	trimer interface [polypeptide binding]; other site
402626011040	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
402626011041	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
402626011042	dimer interface [polypeptide binding]; other site
402626011043	active site
402626011044	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
402626011045	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
402626011046	dimer interface [polypeptide binding]; other site
402626011047	acyl-activating enzyme (AAE) consensus motif; other site
402626011048	putative active site [active]
402626011049	AMP binding site [chemical binding]; other site
402626011050	putative CoA binding site [chemical binding]; other site
402626011051	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
402626011052	CoA-transferase family III; Region: CoA_transf_3; pfam02515
402626011053	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626011054	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626011055	active site
402626011056	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
402626011057	Helix-turn-helix domain; Region: HTH_18; pfam12833
402626011058	SurA N-terminal domain; Region: SurA_N; pfam09312
402626011059	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
402626011060	DDE superfamily endonuclease; Region: DDE_3; pfam13358
402626011061	benzoate transport; Region: 2A0115; TIGR00895
402626011062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626011063	putative substrate translocation pore; other site
402626011064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626011065	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
402626011066	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626011067	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626011068	active site
402626011069	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
402626011070	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
402626011071	Ligand binding site [chemical binding]; other site
402626011072	Electron transfer flavoprotein domain; Region: ETF; pfam01012
402626011073	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
402626011074	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
402626011075	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
402626011076	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626011077	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626011078	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
402626011079	dimerization interface [polypeptide binding]; other site
402626011080	substrate binding pocket [chemical binding]; other site
402626011081	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
402626011082	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
402626011083	Walker A motif; other site
402626011084	ATP binding site [chemical binding]; other site
402626011085	Walker B motif; other site
402626011086	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
402626011087	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
402626011088	ATP binding site [chemical binding]; other site
402626011089	Walker A motif; other site
402626011090	hexamer interface [polypeptide binding]; other site
402626011091	Walker B motif; other site
402626011092	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
402626011093	Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268
402626011094	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
402626011095	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
402626011096	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
402626011097	Walker A motif; other site
402626011098	ATP binding site [chemical binding]; other site
402626011099	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
402626011100	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
402626011101	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
402626011102	conjugal transfer protein TrbL; Provisional; Region: PRK13875
402626011103	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
402626011104	conjugal transfer protein TrbF; Provisional; Region: PRK13872
402626011105	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
402626011106	VirB7 interaction site; other site
402626011107	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
402626011108	Uncharacterized conserved small protein [Function unknown]; Region: COG5639
402626011109	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
402626011110	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
402626011111	P-loop; other site
402626011112	Magnesium ion binding site [ion binding]; other site
402626011113	cobyric acid synthase; Provisional; Region: PRK00784
402626011114	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
402626011115	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
402626011116	catalytic triad [active]
402626011117	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
402626011118	homotrimer interface [polypeptide binding]; other site
402626011119	Walker A motif; other site
402626011120	GTP binding site [chemical binding]; other site
402626011121	Walker B motif; other site
402626011122	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
402626011123	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
402626011124	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626011125	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626011126	homodimer interface [polypeptide binding]; other site
402626011127	catalytic residue [active]
402626011128	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
402626011129	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
402626011130	cobalamin binding residues [chemical binding]; other site
402626011131	putative BtuC binding residues; other site
402626011132	dimer interface [polypeptide binding]; other site
402626011133	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
402626011134	cobalamin synthase; Reviewed; Region: cobS; PRK00235
402626011135	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
402626011136	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
402626011137	putative dimer interface [polypeptide binding]; other site
402626011138	active site pocket [active]
402626011139	putative cataytic base [active]
402626011140	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
402626011141	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
402626011142	homodimer interface [polypeptide binding]; other site
402626011143	Walker A motif; other site
402626011144	ATP binding site [chemical binding]; other site
402626011145	hydroxycobalamin binding site [chemical binding]; other site
402626011146	Walker B motif; other site
402626011147	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
402626011148	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
402626011149	Walker A/P-loop; other site
402626011150	ATP binding site [chemical binding]; other site
402626011151	Q-loop/lid; other site
402626011152	ABC transporter signature motif; other site
402626011153	Walker B; other site
402626011154	D-loop; other site
402626011155	H-loop/switch region; other site
402626011156	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
402626011157	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
402626011158	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
402626011159	dimer interface [polypeptide binding]; other site
402626011160	putative PBP binding regions; other site
402626011161	ABC-ATPase subunit  interface; other site
402626011162	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
402626011163	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
402626011164	N-terminal plug; other site
402626011165	ligand-binding site [chemical binding]; other site
402626011166	Domain of unknown function (DUF1875); Region: DUF1875; pfam08961
402626011167	Cell division protein ZapA; Region: ZapA; pfam05164
402626011168	Uncharacterized conserved protein [Function unknown]; Region: COG2947
402626011169	Protein of unknown function (DUF541); Region: SIMPL; cl01077
402626011170	putative transposase OrfB; Reviewed; Region: PHA02517
402626011171	Integrase core domain; Region: rve; pfam00665
402626011172	Integrase core domain; Region: rve_3; pfam13683
402626011173	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
402626011174	Homeodomain-like domain; Region: HTH_23; cl17451
402626011175	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
402626011176	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
402626011177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626011178	The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453
402626011179	putative dimerization interface [polypeptide binding]; other site
402626011180	putative substrate binding pocket [chemical binding]; other site
402626011181	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
402626011182	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
402626011183	multifunctional aminopeptidase A; Provisional; Region: PRK00913
402626011184	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
402626011185	interface (dimer of trimers) [polypeptide binding]; other site
402626011186	Substrate-binding/catalytic site; other site
402626011187	Zn-binding sites [ion binding]; other site
402626011188	Predicted permeases [General function prediction only]; Region: COG0795
402626011189	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
402626011190	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
402626011191	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
402626011192	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
402626011193	putative active site [active]
402626011194	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
402626011195	putative substrate binding pocket [chemical binding]; other site
402626011196	trimer interface [polypeptide binding]; other site
402626011197	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
402626011198	active site
402626011199	SAM binding site [chemical binding]; other site
402626011200	homodimer interface [polypeptide binding]; other site
402626011201	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
402626011202	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
402626011203	CysD dimerization site [polypeptide binding]; other site
402626011204	G1 box; other site
402626011205	putative GEF interaction site [polypeptide binding]; other site
402626011206	GTP/Mg2+ binding site [chemical binding]; other site
402626011207	Switch I region; other site
402626011208	G2 box; other site
402626011209	G3 box; other site
402626011210	Switch II region; other site
402626011211	G4 box; other site
402626011212	G5 box; other site
402626011213	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
402626011214	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
402626011215	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
402626011216	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
402626011217	Active Sites [active]
402626011218	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
402626011219	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
402626011220	Active Sites [active]
402626011221	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
402626011222	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
402626011223	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
402626011224	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
402626011225	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
402626011226	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
402626011227	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626011228	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
402626011229	substrate binding site [chemical binding]; other site
402626011230	dimerization interface [polypeptide binding]; other site
402626011231	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
402626011232	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
402626011233	putative ligand binding site [chemical binding]; other site
402626011234	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
402626011235	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
402626011236	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
402626011237	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
402626011238	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
402626011239	active site
402626011240	catalytic tetrad [active]
402626011241	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
402626011242	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626011243	putative substrate translocation pore; other site
402626011244	Transcriptional regulators [Transcription]; Region: MarR; COG1846
402626011245	MarR family; Region: MarR_2; pfam12802
402626011246	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
402626011247	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
402626011248	Cl- selectivity filter; other site
402626011249	Cl- binding residues [ion binding]; other site
402626011250	pore gating glutamate residue; other site
402626011251	dimer interface [polypeptide binding]; other site
402626011252	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
402626011253	FOG: CBS domain [General function prediction only]; Region: COG0517
402626011254	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
402626011255	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
402626011256	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
402626011257	metal binding site [ion binding]; metal-binding site
402626011258	active site
402626011259	I-site; other site
402626011260	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
402626011261	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626011262	NAD(P) binding site [chemical binding]; other site
402626011263	active site
402626011264	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
402626011265	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626011266	catalytic loop [active]
402626011267	iron binding site [ion binding]; other site
402626011268	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
402626011269	FAD binding pocket [chemical binding]; other site
402626011270	FAD binding motif [chemical binding]; other site
402626011271	phosphate binding motif [ion binding]; other site
402626011272	beta-alpha-beta structure motif; other site
402626011273	NAD binding pocket [chemical binding]; other site
402626011274	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
402626011275	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
402626011276	inhibitor-cofactor binding pocket; inhibition site
402626011277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626011278	catalytic residue [active]
402626011279	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
402626011280	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626011281	Coenzyme A binding pocket [chemical binding]; other site
402626011282	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
402626011283	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
402626011284	Walker A/P-loop; other site
402626011285	ATP binding site [chemical binding]; other site
402626011286	Q-loop/lid; other site
402626011287	ABC transporter signature motif; other site
402626011288	Walker B; other site
402626011289	D-loop; other site
402626011290	H-loop/switch region; other site
402626011291	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
402626011292	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
402626011293	Walker A/P-loop; other site
402626011294	ATP binding site [chemical binding]; other site
402626011295	Q-loop/lid; other site
402626011296	ABC transporter signature motif; other site
402626011297	Walker B; other site
402626011298	D-loop; other site
402626011299	H-loop/switch region; other site
402626011300	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
402626011301	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
402626011302	TM-ABC transporter signature motif; other site
402626011303	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626011304	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
402626011305	TM-ABC transporter signature motif; other site
402626011306	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
402626011307	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
402626011308	dimerization interface [polypeptide binding]; other site
402626011309	ligand binding site [chemical binding]; other site
402626011310	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
402626011311	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
402626011312	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
402626011313	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
402626011314	hypothetical protein; Reviewed; Region: PRK00024
402626011315	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
402626011316	MPN+ (JAMM) motif; other site
402626011317	Zinc-binding site [ion binding]; other site
402626011318	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
402626011319	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
402626011320	L-aspartate oxidase; Provisional; Region: PRK09077
402626011321	L-aspartate oxidase; Provisional; Region: PRK06175
402626011322	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
402626011323	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
402626011324	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
402626011325	dimerization interface [polypeptide binding]; other site
402626011326	active site
402626011327	quinolinate synthetase; Provisional; Region: PRK09375
402626011328	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
402626011329	Fatty acid desaturase; Region: FA_desaturase; pfam00487
402626011330	Di-iron ligands [ion binding]; other site
402626011331	Transposase; Region: DDE_Tnp_ISL3; pfam01610
402626011332	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
402626011333	Mechanosensitive ion channel; Region: MS_channel; pfam00924
402626011334	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
402626011335	PLD-like domain; Region: PLDc_2; pfam13091
402626011336	putative active site [active]
402626011337	catalytic site [active]
402626011338	ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563
402626011339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626011340	S-adenosylmethionine binding site [chemical binding]; other site
402626011341	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
402626011342	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
402626011343	active site
402626011344	substrate binding site [chemical binding]; other site
402626011345	cosubstrate binding site; other site
402626011346	catalytic site [active]
402626011347	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626011348	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626011349	active site
402626011350	phosphorylation site [posttranslational modification]
402626011351	intermolecular recognition site; other site
402626011352	dimerization interface [polypeptide binding]; other site
402626011353	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626011354	DNA binding residues [nucleotide binding]
402626011355	dimerization interface [polypeptide binding]; other site
402626011356	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626011357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626011358	dimer interface [polypeptide binding]; other site
402626011359	phosphorylation site [posttranslational modification]
402626011360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626011361	ATP binding site [chemical binding]; other site
402626011362	Mg2+ binding site [ion binding]; other site
402626011363	G-X-G motif; other site
402626011364	Response regulator receiver domain; Region: Response_reg; pfam00072
402626011365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626011366	active site
402626011367	phosphorylation site [posttranslational modification]
402626011368	intermolecular recognition site; other site
402626011369	dimerization interface [polypeptide binding]; other site
402626011370	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
402626011371	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
402626011372	active site
402626011373	Riboflavin kinase; Region: Flavokinase; smart00904
402626011374	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
402626011375	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
402626011376	active site
402626011377	HIGH motif; other site
402626011378	nucleotide binding site [chemical binding]; other site
402626011379	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
402626011380	active site
402626011381	KMSKS motif; other site
402626011382	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
402626011383	tRNA binding surface [nucleotide binding]; other site
402626011384	anticodon binding site; other site
402626011385	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
402626011386	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
402626011387	lipoprotein signal peptidase; Provisional; Region: PRK14787
402626011388	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
402626011389	Uncharacterized conserved protein [Function unknown]; Region: COG1434
402626011390	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
402626011391	putative active site [active]
402626011392	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
402626011393	Flavoprotein; Region: Flavoprotein; pfam02441
402626011394	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
402626011395	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
402626011396	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
402626011397	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
402626011398	trimer interface [polypeptide binding]; other site
402626011399	active site
402626011400	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
402626011401	Clp amino terminal domain; Region: Clp_N; pfam02861
402626011402	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626011403	Walker A motif; other site
402626011404	ATP binding site [chemical binding]; other site
402626011405	Walker B motif; other site
402626011406	arginine finger; other site
402626011407	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626011408	Walker A motif; other site
402626011409	ATP binding site [chemical binding]; other site
402626011410	Walker B motif; other site
402626011411	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
402626011412	Uncharacterized conserved protein [Function unknown]; Region: COG2127
402626011413	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
402626011414	DNA-binding site [nucleotide binding]; DNA binding site
402626011415	RNA-binding motif; other site
402626011416	hypothetical protein; Provisional; Region: PRK11667
402626011417	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
402626011418	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
402626011419	Uncharacterized conserved protein [Function unknown]; Region: COG5484
402626011420	Helix-turn-helix domain; Region: HTH_39; pfam14090
402626011421	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
402626011422	integrase; Provisional; Region: PRK09692
402626011423	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
402626011424	active site
402626011425	Int/Topo IB signature motif; other site
402626011426	isocitrate dehydrogenase; Validated; Region: PRK07362
402626011427	isocitrate dehydrogenase; Reviewed; Region: PRK07006
402626011428	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
402626011429	active site
402626011430	metal binding site [ion binding]; metal-binding site
402626011431	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
402626011432	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
402626011433	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
402626011434	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
402626011435	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
402626011436	Predicted periplasmic protein [General function prediction only]; Region: COG3895
402626011437	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
402626011438	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
402626011439	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626011440	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626011441	dimerization interface [polypeptide binding]; other site
402626011442	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626011443	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626011444	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626011445	putative effector binding pocket; other site
402626011446	dimerization interface [polypeptide binding]; other site
402626011447	Helix-turn-helix domain; Region: HTH_28; pfam13518
402626011448	Winged helix-turn helix; Region: HTH_29; pfam13551
402626011449	Winged helix-turn helix; Region: HTH_33; pfam13592
402626011450	DDE superfamily endonuclease; Region: DDE_3; pfam13358
402626011451	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
402626011452	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
402626011453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626011454	putative substrate translocation pore; other site
402626011455	Predicted membrane protein [Function unknown]; Region: COG2259
402626011456	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626011457	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626011458	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
402626011459	putative dimerization interface [polypeptide binding]; other site
402626011460	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
402626011461	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
402626011462	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626011463	citrate-proton symporter; Provisional; Region: PRK15075
402626011464	putative substrate translocation pore; other site
402626011465	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
402626011466	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
402626011467	dimer interface [polypeptide binding]; other site
402626011468	active site
402626011469	catalytic residue [active]
402626011470	Predicted metalloprotease [General function prediction only]; Region: COG2321
402626011471	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
402626011472	glucose-1-dehydrogenase; Provisional; Region: PRK06947
402626011473	classical (c) SDRs; Region: SDR_c; cd05233
402626011474	NAD(P) binding site [chemical binding]; other site
402626011475	active site
402626011476	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
402626011477	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
402626011478	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626011479	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626011480	AlkA N-terminal domain; Region: AlkA_N; pfam06029
402626011481	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
402626011482	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
402626011483	minor groove reading motif; other site
402626011484	helix-hairpin-helix signature motif; other site
402626011485	substrate binding pocket [chemical binding]; other site
402626011486	active site
402626011487	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
402626011488	DNA binding site [nucleotide binding]
402626011489	active site
402626011490	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
402626011491	EamA-like transporter family; Region: EamA; pfam00892
402626011492	EamA-like transporter family; Region: EamA; pfam00892
402626011493	HipA N-terminal domain; Region: Couple_hipA; cl11853
402626011494	HipA-like N-terminal domain; Region: HipA_N; pfam07805
402626011495	HipA-like C-terminal domain; Region: HipA_C; pfam07804
402626011496	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
402626011497	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
402626011498	metal binding site [ion binding]; metal-binding site
402626011499	putative dimer interface [polypeptide binding]; other site
402626011500	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626011501	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
402626011502	substrate binding pocket [chemical binding]; other site
402626011503	membrane-bound complex binding site; other site
402626011504	hinge residues; other site
402626011505	Predicted secreted protein [Function unknown]; Region: COG5445
402626011506	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
402626011507	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
402626011508	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
402626011509	Zn2+ binding site [ion binding]; other site
402626011510	Mg2+ binding site [ion binding]; other site
402626011511	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
402626011512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626011513	dimer interface [polypeptide binding]; other site
402626011514	conserved gate region; other site
402626011515	ABC-ATPase subunit interface; other site
402626011516	putative transposase OrfB; Reviewed; Region: PHA02517
402626011517	Integrase core domain; Region: rve; pfam00665
402626011518	Integrase core domain; Region: rve_3; pfam13683
402626011519	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
402626011520	Homeodomain-like domain; Region: HTH_23; cl17451
402626011521	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
402626011522	citrate-proton symporter; Provisional; Region: PRK15075
402626011523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626011524	putative substrate translocation pore; other site
402626011525	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
402626011526	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
402626011527	NAD binding site [chemical binding]; other site
402626011528	active site
402626011529	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
402626011530	IHF dimer interface [polypeptide binding]; other site
402626011531	IHF - DNA interface [nucleotide binding]; other site
402626011532	HutD; Region: HutD; pfam05962
402626011533	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
402626011534	putative active site [active]
402626011535	putative metal binding site [ion binding]; other site
402626011536	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
402626011537	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
402626011538	Walker A/P-loop; other site
402626011539	ATP binding site [chemical binding]; other site
402626011540	Q-loop/lid; other site
402626011541	ABC transporter signature motif; other site
402626011542	Walker B; other site
402626011543	D-loop; other site
402626011544	H-loop/switch region; other site
402626011545	amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726
402626011546	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626011547	ABC-ATPase subunit interface; other site
402626011548	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
402626011549	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626011550	substrate binding pocket [chemical binding]; other site
402626011551	membrane-bound complex binding site; other site
402626011552	hinge residues; other site
402626011553	Transcriptional regulator [Transcription]; Region: IclR; COG1414
402626011554	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
402626011555	Bacterial transcriptional regulator; Region: IclR; pfam01614
402626011556	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
402626011557	Protein of unknown function (DUF2167); Region: DUF2167; cl01938
402626011558	superoxide dismutase; Provisional; Region: PRK10543
402626011559	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
402626011560	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
402626011561	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
402626011562	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
402626011563	generic binding surface II; other site
402626011564	generic binding surface I; other site
402626011565	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
402626011566	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
402626011567	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
402626011568	tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906
402626011569	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
402626011570	Uncharacterized conserved protein [Function unknown]; Region: COG2835
402626011571	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
402626011572	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
402626011573	Ligand binding site; other site
402626011574	oligomer interface; other site
402626011575	adenylate kinase; Reviewed; Region: adk; PRK00279
402626011576	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
402626011577	AMP-binding site [chemical binding]; other site
402626011578	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
402626011579	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
402626011580	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
402626011581	NAD binding site [chemical binding]; other site
402626011582	homodimer interface [polypeptide binding]; other site
402626011583	homotetramer interface [polypeptide binding]; other site
402626011584	active site
402626011585	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626011586	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626011587	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
402626011588	putative dimerization interface [polypeptide binding]; other site
402626011589	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
402626011590	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
402626011591	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
402626011592	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626011593	Coenzyme A binding pocket [chemical binding]; other site
402626011594	AMIN domain; Region: AMIN; pfam11741
402626011595	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
402626011596	active site
402626011597	metal binding site [ion binding]; metal-binding site
402626011598	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
402626011599	epoxyqueuosine reductase; Region: TIGR00276
402626011600	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
402626011601	4Fe-4S binding domain; Region: Fer4; cl02805
402626011602	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
402626011603	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
402626011604	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
402626011605	DNA binding site [nucleotide binding]
402626011606	active site
402626011607	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
402626011608	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
402626011609	active site
402626011610	DNA binding site [nucleotide binding]
402626011611	Int/Topo IB signature motif; other site
402626011612	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
402626011613	putative deacylase active site [active]
402626011614	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
402626011615	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
402626011616	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
402626011617	conserved cys residue [active]
402626011618	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626011619	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626011620	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
402626011621	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
402626011622	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
402626011623	active site
402626011624	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
402626011625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
402626011626	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
402626011627	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
402626011628	FAD binding domain; Region: FAD_binding_4; pfam01565
402626011629	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
402626011630	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
402626011631	argininosuccinate synthase; Validated; Region: PRK05370
402626011632	argininosuccinate synthase; Provisional; Region: PRK13820
402626011633	ornithine carbamoyltransferase; Provisional; Region: PRK00779
402626011634	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
402626011635	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
402626011636	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
402626011637	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
402626011638	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
402626011639	Uncharacterized conserved protein [Function unknown]; Region: COG2912
402626011640	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
402626011641	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
402626011642	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
402626011643	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
402626011644	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626011645	ATP binding site [chemical binding]; other site
402626011646	Mg2+ binding site [ion binding]; other site
402626011647	G-X-G motif; other site
402626011648	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
402626011649	ATP binding site [chemical binding]; other site
402626011650	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
402626011651	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
402626011652	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
402626011653	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626011654	Coenzyme A binding pocket [chemical binding]; other site
402626011655	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826
402626011656	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
402626011657	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
402626011658	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
402626011659	minor groove reading motif; other site
402626011660	helix-hairpin-helix signature motif; other site
402626011661	substrate binding pocket [chemical binding]; other site
402626011662	active site
402626011663	Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796
402626011664	NapD protein; Region: NapD; pfam03927
402626011665	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
402626011666	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
402626011667	[4Fe-4S] binding site [ion binding]; other site
402626011668	molybdopterin cofactor binding site; other site
402626011669	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
402626011670	molybdopterin cofactor binding site; other site
402626011671	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
402626011672	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
402626011673	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
402626011674	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
402626011675	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626011676	Walker A/P-loop; other site
402626011677	ATP binding site [chemical binding]; other site
402626011678	Q-loop/lid; other site
402626011679	ABC transporter signature motif; other site
402626011680	Walker B; other site
402626011681	D-loop; other site
402626011682	H-loop/switch region; other site
402626011683	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386
402626011684	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
402626011685	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
402626011686	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
402626011687	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
402626011688	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
402626011689	catalytic residues [active]
402626011690	central insert; other site
402626011691	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
402626011692	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
402626011693	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
402626011694	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
402626011695	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626011696	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
402626011697	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
402626011698	DNA binding site [nucleotide binding]
402626011699	active site
402626011700	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
402626011701	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
402626011702	dimerization interface [polypeptide binding]; other site
402626011703	putative ATP binding site [chemical binding]; other site
402626011704	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
402626011705	Domain of unknown function DUF20; Region: UPF0118; pfam01594
402626011706	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
402626011707	DnaA regulatory inactivator Hda; Validated; Region: PRK08903
402626011708	Walker A motif; other site
402626011709	ATP binding site [chemical binding]; other site
402626011710	Walker B motif; other site
402626011711	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
402626011712	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
402626011713	poly(A) polymerase; Region: pcnB; TIGR01942
402626011714	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
402626011715	active site
402626011716	NTP binding site [chemical binding]; other site
402626011717	metal binding triad [ion binding]; metal-binding site
402626011718	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
402626011719	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
402626011720	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
402626011721	catalytic center binding site [active]
402626011722	ATP binding site [chemical binding]; other site
402626011723	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
402626011724	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
402626011725	Substrate-binding site [chemical binding]; other site
402626011726	Substrate specificity [chemical binding]; other site
402626011727	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
402626011728	oligomerization interface [polypeptide binding]; other site
402626011729	active site
402626011730	metal binding site [ion binding]; metal-binding site
402626011731	ABC-type tungstate transport system, periplasmic component [Coenzyme metabolism]; Region: TupA; COG4662
402626011732	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
402626011733	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626011734	Walker A/P-loop; other site
402626011735	ATP binding site [chemical binding]; other site
402626011736	Q-loop/lid; other site
402626011737	ABC transporter signature motif; other site
402626011738	Walker B; other site
402626011739	D-loop; other site
402626011740	H-loop/switch region; other site
402626011741	chorismate binding enzyme; Region: Chorismate_bind; cl10555
402626011742	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
402626011743	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
402626011744	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
402626011745	substrate-cofactor binding pocket; other site
402626011746	homodimer interface [polypeptide binding]; other site
402626011747	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626011748	catalytic residue [active]
402626011749	chaperone protein DnaJ; Provisional; Region: PRK10767
402626011750	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
402626011751	HSP70 interaction site [polypeptide binding]; other site
402626011752	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
402626011753	Zn binding sites [ion binding]; other site
402626011754	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
402626011755	dimer interface [polypeptide binding]; other site
402626011756	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
402626011757	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
402626011758	nucleotide binding site [chemical binding]; other site
402626011759	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248
402626011760	substrate binding site [chemical binding]; other site
402626011761	dimerization interface [polypeptide binding]; other site
402626011762	active site
402626011763	calcium binding site [ion binding]; other site
402626011764	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
402626011765	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
402626011766	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
402626011767	catalytic residues [active]
402626011768	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
402626011769	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
402626011770	dimer interface [polypeptide binding]; other site
402626011771	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
402626011772	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
402626011773	RNA binding surface [nucleotide binding]; other site
402626011774	ferrochelatase; Reviewed; Region: hemH; PRK00035
402626011775	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
402626011776	C-terminal domain interface [polypeptide binding]; other site
402626011777	active site
402626011778	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
402626011779	active site
402626011780	N-terminal domain interface [polypeptide binding]; other site
402626011781	imidazolonepropionase; Validated; Region: PRK09356
402626011782	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
402626011783	active site
402626011784	formimidoylglutamase; Provisional; Region: PRK13775
402626011785	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
402626011786	putative active site [active]
402626011787	putative metal binding site [ion binding]; other site
402626011788	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
402626011789	active sites [active]
402626011790	tetramer interface [polypeptide binding]; other site
402626011791	urocanate hydratase; Provisional; Region: PRK05414
402626011792	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
402626011793	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626011794	DNA-binding site [nucleotide binding]; DNA binding site
402626011795	UTRA domain; Region: UTRA; pfam07702
402626011796	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
402626011797	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626011798	dimer interface [polypeptide binding]; other site
402626011799	conserved gate region; other site
402626011800	putative PBP binding loops; other site
402626011801	ABC-ATPase subunit interface; other site
402626011802	ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525
402626011803	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
402626011804	Walker A/P-loop; other site
402626011805	ATP binding site [chemical binding]; other site
402626011806	Q-loop/lid; other site
402626011807	ABC transporter signature motif; other site
402626011808	Walker B; other site
402626011809	D-loop; other site
402626011810	H-loop/switch region; other site
402626011811	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
402626011812	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626011813	substrate binding pocket [chemical binding]; other site
402626011814	membrane-bound complex binding site; other site
402626011815	hinge residues; other site
402626011816	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
402626011817	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
402626011818	NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155
402626011819	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
402626011820	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
402626011821	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
402626011822	Walker A/P-loop; other site
402626011823	ATP binding site [chemical binding]; other site
402626011824	Q-loop/lid; other site
402626011825	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
402626011826	ABC transporter signature motif; other site
402626011827	Walker B; other site
402626011828	D-loop; other site
402626011829	H-loop/switch region; other site
402626011830	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
402626011831	active site
402626011832	catalytic triad [active]
402626011833	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
402626011834	active site
402626011835	catalytic triad [active]
402626011836	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
402626011837	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
402626011838	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
402626011839	metal binding triad; other site
402626011840	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
402626011841	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
402626011842	metal binding triad; other site
402626011843	Predicted membrane protein [Function unknown]; Region: COG3164
402626011844	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
402626011845	nitrilase; Region: PLN02798
402626011846	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
402626011847	putative active site [active]
402626011848	catalytic triad [active]
402626011849	dimer interface [polypeptide binding]; other site
402626011850	protease TldD; Provisional; Region: tldD; PRK10735
402626011851	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
402626011852	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
402626011853	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
402626011854	Mechanosensitive ion channel; Region: MS_channel; pfam00924
402626011855	ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636
402626011856	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
402626011857	FAD binding domain; Region: FAD_binding_4; pfam01565
402626011858	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
402626011859	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626011860	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
402626011861	dimerization interface [polypeptide binding]; other site
402626011862	substrate binding pocket [chemical binding]; other site
402626011863	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
402626011864	FAD binding domain; Region: FAD_binding_4; pfam01565
402626011865	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
402626011866	FAD binding domain; Region: FAD_binding_4; pfam01565
402626011867	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
402626011868	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
402626011869	Cysteine-rich domain; Region: CCG; pfam02754
402626011870	Cysteine-rich domain; Region: CCG; pfam02754
402626011871	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
402626011872	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
402626011873	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
402626011874	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626011875	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
402626011876	Predicted transcriptional regulator [Transcription]; Region: COG2378
402626011877	HTH domain; Region: HTH_11; pfam08279
402626011878	WYL domain; Region: WYL; pfam13280
402626011879	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
402626011880	catalytic residues [active]
402626011881	dimer interface [polypeptide binding]; other site
402626011882	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
402626011883	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
402626011884	PilX N-terminal; Region: PilX_N; pfam14341
402626011885	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
402626011886	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
402626011887	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
402626011888	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
402626011889	Type II transport protein GspH; Region: GspH; pfam12019
402626011890	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
402626011891	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
402626011892	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
402626011893	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
402626011894	Walker A motif; other site
402626011895	ATP binding site [chemical binding]; other site
402626011896	Walker B motif; other site
402626011897	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
402626011898	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
402626011899	Walker A motif; other site
402626011900	ATP binding site [chemical binding]; other site
402626011901	Walker B motif; other site
402626011902	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
402626011903	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
402626011904	catalytic residue [active]
402626011905	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
402626011906	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
402626011907	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
402626011908	UbiA prenyltransferase family; Region: UbiA; pfam01040
402626011909	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
402626011910	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
402626011911	dimer interface [polypeptide binding]; other site
402626011912	active site
402626011913	heme binding site [chemical binding]; other site
402626011914	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
402626011915	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
402626011916	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
402626011917	dimerization interface [polypeptide binding]; other site
402626011918	DPS ferroxidase diiron center [ion binding]; other site
402626011919	ion pore; other site
402626011920	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
402626011921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626011922	Walker A motif; other site
402626011923	ATP binding site [chemical binding]; other site
402626011924	Walker B motif; other site
402626011925	arginine finger; other site
402626011926	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
402626011927	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
402626011928	putative active site [active]
402626011929	putative metal binding site [ion binding]; other site
402626011930	Domain of unknown function (DUF4338); Region: DUF4338; pfam14236
402626011931	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
402626011932	active site
402626011933	ATP binding site [chemical binding]; other site
402626011934	substrate binding site [chemical binding]; other site
402626011935	activation loop (A-loop); other site
402626011936	TniQ; Region: TniQ; pfam06527
402626011937	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626011938	AAA domain; Region: AAA_22; pfam13401
402626011939	Walker A motif; other site
402626011940	ATP binding site [chemical binding]; other site
402626011941	Walker B motif; other site
402626011942	Integrase core domain; Region: rve; pfam00665
402626011943	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
402626011944	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
402626011945	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
402626011946	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
402626011947	putative metal binding site [ion binding]; other site
402626011948	putative homodimer interface [polypeptide binding]; other site
402626011949	putative homotetramer interface [polypeptide binding]; other site
402626011950	putative homodimer-homodimer interface [polypeptide binding]; other site
402626011951	putative allosteric switch controlling residues; other site
402626011952	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
402626011953	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
402626011954	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
402626011955	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
402626011956	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
402626011957	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626011958	dimerization interface [polypeptide binding]; other site
402626011959	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626011960	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626011961	dimer interface [polypeptide binding]; other site
402626011962	phosphorylation site [posttranslational modification]
402626011963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626011964	ATP binding site [chemical binding]; other site
402626011965	Mg2+ binding site [ion binding]; other site
402626011966	G-X-G motif; other site
402626011967	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
402626011968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626011969	active site
402626011970	phosphorylation site [posttranslational modification]
402626011971	intermolecular recognition site; other site
402626011972	dimerization interface [polypeptide binding]; other site
402626011973	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626011974	DNA binding residues [nucleotide binding]
402626011975	dimerization interface [polypeptide binding]; other site
402626011976	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
402626011977	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626011978	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626011979	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
402626011980	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
402626011981	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
402626011982	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
402626011983	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
402626011984	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
402626011985	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
402626011986	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626011987	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626011988	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
402626011989	dimerization interface [polypeptide binding]; other site
402626011990	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
402626011991	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
402626011992	putative active site [active]
402626011993	putative metal binding site [ion binding]; other site
402626011994	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
402626011995	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
402626011996	generic binding surface II; other site
402626011997	ssDNA binding site; other site
402626011998	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
402626011999	ATP binding site [chemical binding]; other site
402626012000	putative Mg++ binding site [ion binding]; other site
402626012001	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
402626012002	nucleotide binding region [chemical binding]; other site
402626012003	ATP-binding site [chemical binding]; other site
402626012004	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
402626012005	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
402626012006	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
402626012007	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
402626012008	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
402626012009	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
402626012010	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
402626012011	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
402626012012	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
402626012013	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
402626012014	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
402626012015	Protein export membrane protein; Region: SecD_SecF; pfam02355
402626012016	Uncharacterized conserved protein [Function unknown]; Region: COG2353
402626012017	YceI-like domain; Region: YceI; smart00867
402626012018	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
402626012019	adenylosuccinate lyase; Provisional; Region: PRK09285
402626012020	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
402626012021	tetramer interface [polypeptide binding]; other site
402626012022	active site
402626012023	putative glutathione S-transferase; Provisional; Region: PRK10357
402626012024	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
402626012025	putative C-terminal domain interface [polypeptide binding]; other site
402626012026	putative GSH binding site (G-site) [chemical binding]; other site
402626012027	putative dimer interface [polypeptide binding]; other site
402626012028	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
402626012029	dimer interface [polypeptide binding]; other site
402626012030	N-terminal domain interface [polypeptide binding]; other site
402626012031	putative substrate binding pocket (H-site) [chemical binding]; other site
402626012032	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
402626012033	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
402626012034	active site
402626012035	FMN binding site [chemical binding]; other site
402626012036	substrate binding site [chemical binding]; other site
402626012037	3Fe-4S cluster binding site [ion binding]; other site
402626012038	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
402626012039	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
402626012040	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
402626012041	nudix motif; other site
402626012042	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
402626012043	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
402626012044	ligand binding site [chemical binding]; other site
402626012045	homodimer interface [polypeptide binding]; other site
402626012046	NAD(P) binding site [chemical binding]; other site
402626012047	trimer interface B [polypeptide binding]; other site
402626012048	trimer interface A [polypeptide binding]; other site
402626012049	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
402626012050	tetramerization interface [polypeptide binding]; other site
402626012051	active site
402626012052	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
402626012053	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
402626012054	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
402626012055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626012056	active site
402626012057	phosphorylation site [posttranslational modification]
402626012058	intermolecular recognition site; other site
402626012059	dimerization interface [polypeptide binding]; other site
402626012060	Methyltransferase domain; Region: Methyltransf_25; pfam13649
402626012061	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
402626012062	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626012063	dimer interface [polypeptide binding]; other site
402626012064	phosphorylation site [posttranslational modification]
402626012065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626012066	ATP binding site [chemical binding]; other site
402626012067	Mg2+ binding site [ion binding]; other site
402626012068	G-X-G motif; other site
402626012069	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
402626012070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626012071	active site
402626012072	phosphorylation site [posttranslational modification]
402626012073	intermolecular recognition site; other site
402626012074	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626012075	dimerization interface [polypeptide binding]; other site
402626012076	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626012077	dimer interface [polypeptide binding]; other site
402626012078	phosphorylation site [posttranslational modification]
402626012079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626012080	ATP binding site [chemical binding]; other site
402626012081	Mg2+ binding site [ion binding]; other site
402626012082	G-X-G motif; other site
402626012083	Response regulator receiver domain; Region: Response_reg; pfam00072
402626012084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626012085	active site
402626012086	phosphorylation site [posttranslational modification]
402626012087	intermolecular recognition site; other site
402626012088	dimerization interface [polypeptide binding]; other site
402626012089	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
402626012090	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
402626012091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
402626012092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
402626012093	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
402626012094	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
402626012095	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
402626012096	putative catalytic cysteine [active]
402626012097	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
402626012098	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
402626012099	Lipopolysaccharide-assembly; Region: LptE; cl01125
402626012100	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
402626012101	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
402626012102	HIGH motif; other site
402626012103	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
402626012104	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
402626012105	active site
402626012106	KMSKS motif; other site
402626012107	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
402626012108	tRNA binding surface [nucleotide binding]; other site
402626012109	dihydrodipicolinate reductase; Provisional; Region: PRK00048
402626012110	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
402626012111	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
402626012112	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
402626012113	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
402626012114	ferric uptake regulator; Provisional; Region: fur; PRK09462
402626012115	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
402626012116	metal binding site 2 [ion binding]; metal-binding site
402626012117	putative DNA binding helix; other site
402626012118	metal binding site 1 [ion binding]; metal-binding site
402626012119	dimer interface [polypeptide binding]; other site
402626012120	structural Zn2+ binding site [ion binding]; other site
402626012121	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626012122	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626012123	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
402626012124	putative substrate binding pocket [chemical binding]; other site
402626012125	putative dimerization interface [polypeptide binding]; other site
402626012126	Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932
402626012127	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
402626012128	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
402626012129	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
402626012130	transketolase; Reviewed; Region: PRK12753
402626012131	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
402626012132	TPP-binding site [chemical binding]; other site
402626012133	dimer interface [polypeptide binding]; other site
402626012134	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
402626012135	PYR/PP interface [polypeptide binding]; other site
402626012136	dimer interface [polypeptide binding]; other site
402626012137	TPP binding site [chemical binding]; other site
402626012138	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
402626012139	galactonate dehydratase; Provisional; Region: PRK14017
402626012140	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
402626012141	putative active site pocket [active]
402626012142	putative metal binding site [ion binding]; other site
402626012143	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
402626012144	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
402626012145	active site
402626012146	intersubunit interface [polypeptide binding]; other site
402626012147	catalytic residue [active]
402626012148	short chain dehydrogenase; Provisional; Region: PRK07063
402626012149	classical (c) SDRs; Region: SDR_c; cd05233
402626012150	NAD(P) binding site [chemical binding]; other site
402626012151	active site
402626012152	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
402626012153	active site
402626012154	catalytic residues [active]
402626012155	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
402626012156	Strictosidine synthase; Region: Str_synth; pfam03088
402626012157	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626012158	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
402626012159	TM-ABC transporter signature motif; other site
402626012160	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
402626012161	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
402626012162	Walker A/P-loop; other site
402626012163	ATP binding site [chemical binding]; other site
402626012164	Q-loop/lid; other site
402626012165	ABC transporter signature motif; other site
402626012166	Walker B; other site
402626012167	D-loop; other site
402626012168	H-loop/switch region; other site
402626012169	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
402626012170	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
402626012171	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
402626012172	ligand binding site [chemical binding]; other site
402626012173	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
402626012174	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
402626012175	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626012176	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626012177	trimer interface [polypeptide binding]; other site
402626012178	eyelet of channel; other site
402626012179	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
402626012180	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626012181	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
402626012182	dimerization interface [polypeptide binding]; other site
402626012183	substrate binding pocket [chemical binding]; other site
402626012184	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
402626012185	putative dimer interface [polypeptide binding]; other site
402626012186	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626012187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
402626012188	RNA methyltransferase, RsmE family; Region: TIGR00046
402626012189	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
402626012190	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
402626012191	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626012192	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
402626012193	putative dimerization interface [polypeptide binding]; other site
402626012194	dihydroxy-acid dehydratase; Validated; Region: PRK06131
402626012195	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
402626012196	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
402626012197	inhibitor site; inhibition site
402626012198	active site
402626012199	dimer interface [polypeptide binding]; other site
402626012200	catalytic residue [active]
402626012201	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
402626012202	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
402626012203	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
402626012204	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
402626012205	ligand binding site [chemical binding]; other site
402626012206	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
402626012207	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
402626012208	Walker A/P-loop; other site
402626012209	ATP binding site [chemical binding]; other site
402626012210	Q-loop/lid; other site
402626012211	ABC transporter signature motif; other site
402626012212	Walker B; other site
402626012213	D-loop; other site
402626012214	H-loop/switch region; other site
402626012215	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
402626012216	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626012217	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
402626012218	TM-ABC transporter signature motif; other site
402626012219	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
402626012220	putative RNAase interaction site [polypeptide binding]; other site
402626012221	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
402626012222	active site
402626012223	barstar interaction site; other site
402626012224	malic enzyme; Reviewed; Region: PRK12862
402626012225	Malic enzyme, N-terminal domain; Region: malic; pfam00390
402626012226	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
402626012227	putative NAD(P) binding site [chemical binding]; other site
402626012228	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
402626012229	thiamine monophosphate kinase; Provisional; Region: PRK05731
402626012230	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
402626012231	ATP binding site [chemical binding]; other site
402626012232	dimerization interface [polypeptide binding]; other site
402626012233	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
402626012234	tetramer interfaces [polypeptide binding]; other site
402626012235	binuclear metal-binding site [ion binding]; other site
402626012236	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
402626012237	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
402626012238	active site
402626012239	dimer interface [polypeptide binding]; other site
402626012240	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
402626012241	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
402626012242	Cl binding site [ion binding]; other site
402626012243	oligomer interface [polypeptide binding]; other site
402626012244	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
402626012245	monofunctional biosynthetic peptidoglycan transglycosylase; Region: mono_pep_trsgly; TIGR02070
402626012246	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
402626012247	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
402626012248	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
402626012249	shikimate binding site; other site
402626012250	NAD(P) binding site [chemical binding]; other site
402626012251	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
402626012252	TonB C terminal; Region: TonB_2; pfam13103
402626012253	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
402626012254	RNB domain; Region: RNB; pfam00773
402626012255	4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161
402626012256	Predicted esterase [General function prediction only]; Region: COG3150
402626012257	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
402626012258	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
402626012259	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
402626012260	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
402626012261	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
402626012262	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
402626012263	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
402626012264	catalytic residues [active]
402626012265	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
402626012266	Dehydroquinase class II; Region: DHquinase_II; pfam01220
402626012267	trimer interface [polypeptide binding]; other site
402626012268	active site
402626012269	dimer interface [polypeptide binding]; other site
402626012270	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
402626012271	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
402626012272	carboxyltransferase (CT) interaction site; other site
402626012273	biotinylation site [posttranslational modification]; other site
402626012274	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
402626012275	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
402626012276	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
402626012277	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
402626012278	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
402626012279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626012280	S-adenosylmethionine binding site [chemical binding]; other site
402626012281	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
402626012282	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
402626012283	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
402626012284	dimer interface [polypeptide binding]; other site
402626012285	catalytic triad [active]
402626012286	peroxidatic and resolving cysteines [active]
402626012287	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
402626012288	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
402626012289	substrate binding site [chemical binding]; other site
402626012290	ATP binding site [chemical binding]; other site
402626012291	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
402626012292	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
402626012293	Cache domain; Region: Cache_2; pfam08269
402626012294	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626012295	dimer interface [polypeptide binding]; other site
402626012296	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
402626012297	putative CheW interface [polypeptide binding]; other site
402626012298	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
402626012299	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
402626012300	putative active site [active]
402626012301	Zn binding site [ion binding]; other site
402626012302	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
402626012303	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
402626012304	dimer interface [polypeptide binding]; other site
402626012305	putative radical transfer pathway; other site
402626012306	diiron center [ion binding]; other site
402626012307	tyrosyl radical; other site
402626012308	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
402626012309	ATP cone domain; Region: ATP-cone; pfam03477
402626012310	Class I ribonucleotide reductase; Region: RNR_I; cd01679
402626012311	active site
402626012312	dimer interface [polypeptide binding]; other site
402626012313	catalytic residues [active]
402626012314	effector binding site; other site
402626012315	R2 peptide binding site; other site
402626012316	Uncharacterized conserved protein [Function unknown]; Region: COG3379
402626012317	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
402626012318	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
402626012319	Phosphoesterase family; Region: Phosphoesterase; pfam04185
402626012320	Domain of unknown function (DUF756); Region: DUF756; pfam05506
402626012321	Domain of unknown function (DUF756); Region: DUF756; pfam05506
402626012322	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
402626012323	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
402626012324	amidase catalytic site [active]
402626012325	Zn binding residues [ion binding]; other site
402626012326	substrate binding site [chemical binding]; other site
402626012327	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
402626012328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626012329	active site
402626012330	phosphorylation site [posttranslational modification]
402626012331	intermolecular recognition site; other site
402626012332	dimerization interface [polypeptide binding]; other site
402626012333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626012334	Walker A motif; other site
402626012335	ATP binding site [chemical binding]; other site
402626012336	Walker B motif; other site
402626012337	arginine finger; other site
402626012338	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626012339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
402626012340	putative active site [active]
402626012341	heme pocket [chemical binding]; other site
402626012342	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626012343	dimer interface [polypeptide binding]; other site
402626012344	phosphorylation site [posttranslational modification]
402626012345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626012346	ATP binding site [chemical binding]; other site
402626012347	Mg2+ binding site [ion binding]; other site
402626012348	G-X-G motif; other site
402626012349	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
402626012350	signal recognition particle protein; Provisional; Region: PRK10867
402626012351	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
402626012352	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
402626012353	P loop; other site
402626012354	GTP binding site [chemical binding]; other site
402626012355	Signal peptide binding domain; Region: SRP_SPB; pfam02978
402626012356	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
402626012357	active site
402626012358	MarC family integral membrane protein; Region: MarC; cl00919
402626012359	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
402626012360	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
402626012361	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
402626012362	N-acetyl-D-glucosamine binding site [chemical binding]; other site
402626012363	catalytic residue [active]
402626012364	prolyl-tRNA synthetase; Provisional; Region: PRK09194
402626012365	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
402626012366	dimer interface [polypeptide binding]; other site
402626012367	motif 1; other site
402626012368	active site
402626012369	motif 2; other site
402626012370	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
402626012371	putative deacylase active site [active]
402626012372	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
402626012373	active site
402626012374	motif 3; other site
402626012375	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
402626012376	anticodon binding site; other site
402626012377	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
402626012378	putative active site [active]
402626012379	Ap4A binding site [chemical binding]; other site
402626012380	nudix motif; other site
402626012381	putative metal binding site [ion binding]; other site
402626012382	CNP1-like family; Region: CNP1; pfam08750
402626012383	gamma-glutamyl kinase; Provisional; Region: PRK05429
402626012384	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
402626012385	nucleotide binding site [chemical binding]; other site
402626012386	homotetrameric interface [polypeptide binding]; other site
402626012387	putative phosphate binding site [ion binding]; other site
402626012388	putative allosteric binding site; other site
402626012389	PUA domain; Region: PUA; pfam01472
402626012390	GTPase CgtA; Reviewed; Region: obgE; PRK12299
402626012391	GTP1/OBG; Region: GTP1_OBG; pfam01018
402626012392	Obg GTPase; Region: Obg; cd01898
402626012393	G1 box; other site
402626012394	GTP/Mg2+ binding site [chemical binding]; other site
402626012395	Switch I region; other site
402626012396	G2 box; other site
402626012397	G3 box; other site
402626012398	Switch II region; other site
402626012399	G4 box; other site
402626012400	G5 box; other site
402626012401	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
402626012402	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
402626012403	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
402626012404	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
402626012405	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
402626012406	substrate binding pocket [chemical binding]; other site
402626012407	chain length determination region; other site
402626012408	substrate-Mg2+ binding site; other site
402626012409	catalytic residues [active]
402626012410	aspartate-rich region 1; other site
402626012411	active site lid residues [active]
402626012412	aspartate-rich region 2; other site
402626012413	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
402626012414	Domain of unknown function DUF21; Region: DUF21; pfam01595
402626012415	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
402626012416	Transporter associated domain; Region: CorC_HlyC; smart01091
402626012417	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
402626012418	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
402626012419	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
402626012420	Walker A motif; other site
402626012421	ATP binding site [chemical binding]; other site
402626012422	Walker B motif; other site
402626012423	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
402626012424	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
402626012425	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
402626012426	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
402626012427	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
402626012428	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
402626012429	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
402626012430	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
402626012431	CoA-binding site [chemical binding]; other site
402626012432	ATP-binding [chemical binding]; other site
402626012433	hypothetical protein; Provisional; Region: PRK05287
402626012434	Domain of unknown function (DUF329); Region: DUF329; pfam03884
402626012435	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
402626012436	active site
402626012437	8-oxo-dGMP binding site [chemical binding]; other site
402626012438	nudix motif; other site
402626012439	metal binding site [ion binding]; metal-binding site
402626012440	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
402626012441	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626012442	Walker A motif; other site
402626012443	ATP binding site [chemical binding]; other site
402626012444	Walker B motif; other site
402626012445	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
402626012446	heterotetramer interface [polypeptide binding]; other site
402626012447	active site pocket [active]
402626012448	cleavage site
402626012449	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
402626012450	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
402626012451	SEC-C motif; Region: SEC-C; pfam02810
402626012452	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
402626012453	Peptidase family M23; Region: Peptidase_M23; pfam01551
402626012454	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
402626012455	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
402626012456	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
402626012457	catalytic triad [active]
402626012458	dimer interface [polypeptide binding]; other site
402626012459	cell division protein FtsZ; Validated; Region: PRK09330
402626012460	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
402626012461	nucleotide binding site [chemical binding]; other site
402626012462	SulA interaction site; other site
402626012463	cell division protein FtsA; Region: ftsA; TIGR01174
402626012464	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
402626012465	nucleotide binding site [chemical binding]; other site
402626012466	Cell division protein FtsA; Region: FtsA; pfam14450
402626012467	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
402626012468	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
402626012469	Cell division protein FtsQ; Region: FtsQ; pfam03799
402626012470	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
402626012471	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
402626012472	ATP-grasp domain; Region: ATP-grasp_4; cl17255
402626012473	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
402626012474	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
402626012475	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
402626012476	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
402626012477	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
402626012478	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
402626012479	active site
402626012480	homodimer interface [polypeptide binding]; other site
402626012481	cell division protein FtsW; Region: ftsW; TIGR02614
402626012482	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
402626012483	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
402626012484	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
402626012485	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
402626012486	Mg++ binding site [ion binding]; other site
402626012487	putative catalytic motif [active]
402626012488	putative substrate binding site [chemical binding]; other site
402626012489	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
402626012490	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
402626012491	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
402626012492	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
402626012493	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
402626012494	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
402626012495	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
402626012496	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
402626012497	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
402626012498	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
402626012499	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
402626012500	Cell division protein FtsL; Region: FtsL; cl11433
402626012501	MraW methylase family; Region: Methyltransf_5; cl17771
402626012502	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
402626012503	cell division protein MraZ; Reviewed; Region: PRK00326
402626012504	MraZ protein; Region: MraZ; pfam02381
402626012505	MraZ protein; Region: MraZ; pfam02381
402626012506	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
402626012507	diiron binding motif [ion binding]; other site
402626012508	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626012509	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626012510	trimer interface [polypeptide binding]; other site
402626012511	eyelet of channel; other site
402626012512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626012513	metabolite-proton symporter; Region: 2A0106; TIGR00883
402626012514	putative substrate translocation pore; other site
402626012515	hypothetical protein; Provisional; Region: PRK09256
402626012516	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
402626012517	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
402626012518	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
402626012519	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
402626012520	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
402626012521	acyl-activating enzyme (AAE) consensus motif; other site
402626012522	putative AMP binding site [chemical binding]; other site
402626012523	putative active site [active]
402626012524	putative CoA binding site [chemical binding]; other site
402626012525	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
402626012526	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
402626012527	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
402626012528	putative [4Fe-4S] binding site [ion binding]; other site
402626012529	putative molybdopterin cofactor binding site [chemical binding]; other site
402626012530	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
402626012531	putative molybdopterin cofactor binding site; other site
402626012532	Transcriptional regulators [Transcription]; Region: PurR; COG1609
402626012533	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
402626012534	DNA binding site [nucleotide binding]
402626012535	domain linker motif; other site
402626012536	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
402626012537	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
402626012538	active site
402626012539	phosphorylation site [posttranslational modification]
402626012540	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
402626012541	dimerization domain swap beta strand [polypeptide binding]; other site
402626012542	regulatory protein interface [polypeptide binding]; other site
402626012543	active site
402626012544	regulatory phosphorylation site [posttranslational modification]; other site
402626012545	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
402626012546	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
402626012547	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
402626012548	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
402626012549	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
402626012550	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
402626012551	putative substrate binding site [chemical binding]; other site
402626012552	putative ATP binding site [chemical binding]; other site
402626012553	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
402626012554	active site
402626012555	P-loop; other site
402626012556	phosphorylation site [posttranslational modification]
402626012557	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
402626012558	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
402626012559	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
402626012560	putative ligand binding site [chemical binding]; other site
402626012561	acetylornithine deacetylase; Provisional; Region: PRK07522
402626012562	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
402626012563	metal binding site [ion binding]; metal-binding site
402626012564	putative dimer interface [polypeptide binding]; other site
402626012565	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
402626012566	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
402626012567	metal binding site [ion binding]; metal-binding site
402626012568	putative dimer interface [polypeptide binding]; other site
402626012569	enoyl-CoA hydratase; Provisional; Region: PRK05862
402626012570	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626012571	substrate binding site [chemical binding]; other site
402626012572	oxyanion hole (OAH) forming residues; other site
402626012573	trimer interface [polypeptide binding]; other site
402626012574	enoyl-CoA hydratase; Provisional; Region: PRK08140
402626012575	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
402626012576	substrate binding site [chemical binding]; other site
402626012577	oxyanion hole (OAH) forming residues; other site
402626012578	trimer interface [polypeptide binding]; other site
402626012579	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
402626012580	CoenzymeA binding site [chemical binding]; other site
402626012581	subunit interaction site [polypeptide binding]; other site
402626012582	PHB binding site; other site
402626012583	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
402626012584	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
402626012585	acyl-activating enzyme (AAE) consensus motif; other site
402626012586	AMP binding site [chemical binding]; other site
402626012587	active site
402626012588	CoA binding site [chemical binding]; other site
402626012589	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
402626012590	MltA specific insert domain; Region: MltA; smart00925
402626012591	3D domain; Region: 3D; pfam06725
402626012592	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
402626012593	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
402626012594	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
402626012595	substrate binding site [chemical binding]; other site
402626012596	hexamer interface [polypeptide binding]; other site
402626012597	metal binding site [ion binding]; metal-binding site
402626012598	phosphoglycolate phosphatase; Provisional; Region: PRK13222
402626012599	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626012600	motif II; other site
402626012601	anthranilate synthase component I; Provisional; Region: PRK13565
402626012602	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
402626012603	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
402626012604	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
402626012605	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
402626012606	glutamine binding [chemical binding]; other site
402626012607	catalytic triad [active]
402626012608	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
402626012609	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
402626012610	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
402626012611	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
402626012612	active site
402626012613	ribulose/triose binding site [chemical binding]; other site
402626012614	phosphate binding site [ion binding]; other site
402626012615	substrate (anthranilate) binding pocket [chemical binding]; other site
402626012616	product (indole) binding pocket [chemical binding]; other site
402626012617	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
402626012618	putative active site [active]
402626012619	putative metal binding residues [ion binding]; other site
402626012620	signature motif; other site
402626012621	putative triphosphate binding site [ion binding]; other site
402626012622	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
402626012623	ligand binding site [chemical binding]; other site
402626012624	active site
402626012625	UGI interface [polypeptide binding]; other site
402626012626	catalytic site [active]
402626012627	Predicted membrane protein [Function unknown]; Region: COG1289
402626012628	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
402626012629	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
402626012630	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
402626012631	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
402626012632	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
402626012633	protein binding site [polypeptide binding]; other site
402626012634	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
402626012635	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
402626012636	NADP binding site [chemical binding]; other site
402626012637	dimer interface [polypeptide binding]; other site
402626012638	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
402626012639	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
402626012640	dimerization domain [polypeptide binding]; other site
402626012641	dimer interface [polypeptide binding]; other site
402626012642	catalytic residues [active]
402626012643	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608
402626012644	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
402626012645	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
402626012646	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
402626012647	N-acetyl-D-glucosamine binding site [chemical binding]; other site
402626012648	catalytic residue [active]
402626012649	Flagellar protein FliT; Region: FliT; pfam05400
402626012650	GTP-binding protein YchF; Reviewed; Region: PRK09601
402626012651	YchF GTPase; Region: YchF; cd01900
402626012652	G1 box; other site
402626012653	GTP/Mg2+ binding site [chemical binding]; other site
402626012654	Switch I region; other site
402626012655	G2 box; other site
402626012656	Switch II region; other site
402626012657	G3 box; other site
402626012658	G4 box; other site
402626012659	G5 box; other site
402626012660	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
402626012661	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
402626012662	GAF domain; Region: GAF; pfam01590
402626012663	Phytochrome region; Region: PHY; pfam00360
402626012664	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626012665	dimer interface [polypeptide binding]; other site
402626012666	phosphorylation site [posttranslational modification]
402626012667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626012668	ATP binding site [chemical binding]; other site
402626012669	Mg2+ binding site [ion binding]; other site
402626012670	G-X-G motif; other site
402626012671	Response regulator receiver domain; Region: Response_reg; pfam00072
402626012672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626012673	active site
402626012674	phosphorylation site [posttranslational modification]
402626012675	intermolecular recognition site; other site
402626012676	dimerization interface [polypeptide binding]; other site
402626012677	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
402626012678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626012679	active site
402626012680	phosphorylation site [posttranslational modification]
402626012681	intermolecular recognition site; other site
402626012682	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
402626012683	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626012684	putative active site [active]
402626012685	heme pocket [chemical binding]; other site
402626012686	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626012687	dimer interface [polypeptide binding]; other site
402626012688	phosphorylation site [posttranslational modification]
402626012689	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626012690	ATP binding site [chemical binding]; other site
402626012691	Mg2+ binding site [ion binding]; other site
402626012692	G-X-G motif; other site
402626012693	Response regulator receiver domain; Region: Response_reg; pfam00072
402626012694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626012695	active site
402626012696	phosphorylation site [posttranslational modification]
402626012697	intermolecular recognition site; other site
402626012698	dimerization interface [polypeptide binding]; other site
402626012699	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
402626012700	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
402626012701	tRNA; other site
402626012702	putative tRNA binding site [nucleotide binding]; other site
402626012703	putative NADP binding site [chemical binding]; other site
402626012704	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
402626012705	peptide chain release factor 1; Validated; Region: prfA; PRK00591
402626012706	This domain is found in peptide chain release factors; Region: PCRF; smart00937
402626012707	RF-1 domain; Region: RF-1; pfam00472
402626012708	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
402626012709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
402626012710	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
402626012711	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
402626012712	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
402626012713	putative active site [active]
402626012714	putative NTP binding site [chemical binding]; other site
402626012715	putative nucleic acid binding site [nucleotide binding]; other site
402626012716	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
402626012717	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
402626012718	active site
402626012719	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
402626012720	putative GSH binding site [chemical binding]; other site
402626012721	catalytic residues [active]
402626012722	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
402626012723	Flavoprotein; Region: Flavoprotein; pfam02441
402626012724	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
402626012725	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
402626012726	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
402626012727	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
402626012728	Ligand binding site; other site
402626012729	DXD motif; other site
402626012730	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
402626012731	putative deacylase active site [active]
402626012732	Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369
402626012733	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
402626012734	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
402626012735	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626012736	Walker A/P-loop; other site
402626012737	ATP binding site [chemical binding]; other site
402626012738	Q-loop/lid; other site
402626012739	ABC transporter signature motif; other site
402626012740	Walker B; other site
402626012741	D-loop; other site
402626012742	H-loop/switch region; other site
402626012743	ABC transporter; Region: ABC_tran_2; pfam12848
402626012744	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
402626012745	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
402626012746	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
402626012747	Subunit I/III interface [polypeptide binding]; other site
402626012748	Subunit III/IV interface [polypeptide binding]; other site
402626012749	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
402626012750	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
402626012751	D-pathway; other site
402626012752	Putative ubiquinol binding site [chemical binding]; other site
402626012753	Low-spin heme (heme b) binding site [chemical binding]; other site
402626012754	Putative water exit pathway; other site
402626012755	Binuclear center (heme o3/CuB) [ion binding]; other site
402626012756	K-pathway; other site
402626012757	Putative proton exit pathway; other site
402626012758	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
402626012759	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
402626012760	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
402626012761	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
402626012762	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
402626012763	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
402626012764	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
402626012765	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
402626012766	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
402626012767	non-specific DNA binding site [nucleotide binding]; other site
402626012768	salt bridge; other site
402626012769	sequence-specific DNA binding site [nucleotide binding]; other site
402626012770	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
402626012771	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
402626012772	ATP binding site [chemical binding]; other site
402626012773	putative Mg++ binding site [ion binding]; other site
402626012774	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
402626012775	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
402626012776	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
402626012777	Part of AAA domain; Region: AAA_19; pfam13245
402626012778	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
402626012779	Family description; Region: UvrD_C_2; pfam13538
402626012780	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
402626012781	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
402626012782	AAA domain; Region: AAA_21; pfam13304
402626012783	Walker A/P-loop; other site
402626012784	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
402626012785	putative active site [active]
402626012786	putative metal-binding site [ion binding]; other site
402626012787	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
402626012788	HsdM N-terminal domain; Region: HsdM_N; pfam12161
402626012789	Methyltransferase domain; Region: Methyltransf_26; pfam13659
402626012790	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
402626012791	HsdM N-terminal domain; Region: HsdM_N; pfam12161
402626012792	Methyltransferase domain; Region: Methyltransf_26; pfam13659
402626012793	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
402626012794	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
402626012795	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
402626012796	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
402626012797	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
402626012798	integrase; Provisional; Region: int; PHA02601
402626012799	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
402626012800	active site
402626012801	DNA binding site [nucleotide binding]
402626012802	Int/Topo IB signature motif; other site
402626012803	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
402626012804	stringent starvation protein A; Provisional; Region: sspA; PRK09481
402626012805	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
402626012806	C-terminal domain interface [polypeptide binding]; other site
402626012807	putative GSH binding site (G-site) [chemical binding]; other site
402626012808	dimer interface [polypeptide binding]; other site
402626012809	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
402626012810	dimer interface [polypeptide binding]; other site
402626012811	N-terminal domain interface [polypeptide binding]; other site
402626012812	Cytochrome c; Region: Cytochrom_C; cl11414
402626012813	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
402626012814	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
402626012815	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
402626012816	Qi binding site; other site
402626012817	intrachain domain interface; other site
402626012818	interchain domain interface [polypeptide binding]; other site
402626012819	heme bH binding site [chemical binding]; other site
402626012820	heme bL binding site [chemical binding]; other site
402626012821	Qo binding site; other site
402626012822	interchain domain interface [polypeptide binding]; other site
402626012823	intrachain domain interface; other site
402626012824	Qi binding site; other site
402626012825	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
402626012826	Qo binding site; other site
402626012827	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
402626012828	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
402626012829	[2Fe-2S] cluster binding site [ion binding]; other site
402626012830	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
402626012831	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
402626012832	Uncharacterized conserved protein [Function unknown]; Region: COG0327
402626012833	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
402626012834	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
402626012835	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
402626012836	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
402626012837	protein binding site [polypeptide binding]; other site
402626012838	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626012839	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626012840	trimer interface [polypeptide binding]; other site
402626012841	eyelet of channel; other site
402626012842	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
402626012843	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
402626012844	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
402626012845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626012846	active site
402626012847	phosphorylation site [posttranslational modification]
402626012848	intermolecular recognition site; other site
402626012849	dimerization interface [polypeptide binding]; other site
402626012850	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626012851	DNA binding site [nucleotide binding]
402626012852	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
402626012853	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626012854	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626012855	dimer interface [polypeptide binding]; other site
402626012856	phosphorylation site [posttranslational modification]
402626012857	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626012858	ATP binding site [chemical binding]; other site
402626012859	Mg2+ binding site [ion binding]; other site
402626012860	G-X-G motif; other site
402626012861	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
402626012862	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
402626012863	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
402626012864	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626012865	dimer interface [polypeptide binding]; other site
402626012866	conserved gate region; other site
402626012867	ABC-ATPase subunit interface; other site
402626012868	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626012869	dimer interface [polypeptide binding]; other site
402626012870	conserved gate region; other site
402626012871	putative PBP binding loops; other site
402626012872	ABC-ATPase subunit interface; other site
402626012873	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
402626012874	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
402626012875	Walker A/P-loop; other site
402626012876	ATP binding site [chemical binding]; other site
402626012877	Q-loop/lid; other site
402626012878	ABC transporter signature motif; other site
402626012879	Walker B; other site
402626012880	D-loop; other site
402626012881	H-loop/switch region; other site
402626012882	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
402626012883	sec-independent translocase; Provisional; Region: tatB; PRK01919
402626012884	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
402626012885	Predicted membrane protein [Function unknown]; Region: COG3671
402626012886	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
402626012887	metal binding site [ion binding]; metal-binding site
402626012888	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
402626012889	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
402626012890	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
402626012891	substrate binding site [chemical binding]; other site
402626012892	glutamase interaction surface [polypeptide binding]; other site
402626012893	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
402626012894	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
402626012895	catalytic residues [active]
402626012896	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
402626012897	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
402626012898	putative active site [active]
402626012899	oxyanion strand; other site
402626012900	catalytic triad [active]
402626012901	MarC family integral membrane protein; Region: MarC; cl00919
402626012902	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
402626012903	putative active site pocket [active]
402626012904	4-fold oligomerization interface [polypeptide binding]; other site
402626012905	metal binding residues [ion binding]; metal-binding site
402626012906	3-fold/trimer interface [polypeptide binding]; other site
402626012907	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
402626012908	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626012909	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626012910	homodimer interface [polypeptide binding]; other site
402626012911	catalytic residue [active]
402626012912	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
402626012913	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
402626012914	NAD binding site [chemical binding]; other site
402626012915	dimerization interface [polypeptide binding]; other site
402626012916	product binding site; other site
402626012917	substrate binding site [chemical binding]; other site
402626012918	zinc binding site [ion binding]; other site
402626012919	catalytic residues [active]
402626012920	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
402626012921	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
402626012922	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
402626012923	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
402626012924	hinge; other site
402626012925	active site
402626012926	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
402626012927	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
402626012928	ABC-2 type transporter; Region: ABC2_membrane; cl17235
402626012929	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
402626012930	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
402626012931	Walker A/P-loop; other site
402626012932	ATP binding site [chemical binding]; other site
402626012933	Q-loop/lid; other site
402626012934	ABC transporter signature motif; other site
402626012935	Walker B; other site
402626012936	D-loop; other site
402626012937	H-loop/switch region; other site
402626012938	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
402626012939	anti sigma factor interaction site; other site
402626012940	regulatory phosphorylation site [posttranslational modification]; other site
402626012941	ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854
402626012942	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
402626012943	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
402626012944	mce related protein; Region: MCE; pfam02470
402626012945	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
402626012946	Permease; Region: Permease; pfam02405
402626012947	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
402626012948	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
402626012949	Walker A/P-loop; other site
402626012950	ATP binding site [chemical binding]; other site
402626012951	Q-loop/lid; other site
402626012952	ABC transporter signature motif; other site
402626012953	Walker B; other site
402626012954	D-loop; other site
402626012955	H-loop/switch region; other site
402626012956	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
402626012957	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
402626012958	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
402626012959	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
402626012960	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
402626012961	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
402626012962	active site
402626012963	dimer interface [polypeptide binding]; other site
402626012964	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
402626012965	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
402626012966	active site
402626012967	FMN binding site [chemical binding]; other site
402626012968	substrate binding site [chemical binding]; other site
402626012969	3Fe-4S cluster binding site [ion binding]; other site
402626012970	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
402626012971	domain interface; other site
402626012972	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
402626012973	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
402626012974	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
402626012975	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
402626012976	Zn2+ binding site [ion binding]; other site
402626012977	Mg2+ binding site [ion binding]; other site
402626012978	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
402626012979	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
402626012980	active site
402626012981	dimer interface [polypeptide binding]; other site
402626012982	metal binding site [ion binding]; metal-binding site
402626012983	shikimate kinase; Reviewed; Region: aroK; PRK00131
402626012984	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
402626012985	ADP binding site [chemical binding]; other site
402626012986	magnesium binding site [ion binding]; other site
402626012987	putative shikimate binding site; other site
402626012988	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
402626012989	AMIN domain; Region: AMIN; pfam11741
402626012990	Secretin and TonB N terminus short domain; Region: STN; smart00965
402626012991	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
402626012992	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
402626012993	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
402626012994	Pilus assembly protein, PilP; Region: PilP; pfam04351
402626012995	Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167
402626012996	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
402626012997	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
402626012998	Cell division protein FtsA; Region: FtsA; cl17206
402626012999	Competence protein A; Region: Competence_A; pfam11104
402626013000	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
402626013001	Transglycosylase; Region: Transgly; pfam00912
402626013002	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
402626013003	frataxin-like protein; Provisional; Region: cyaY; PRK00446
402626013004	diaminopimelate decarboxylase; Region: lysA; TIGR01048
402626013005	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
402626013006	active site
402626013007	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
402626013008	substrate binding site [chemical binding]; other site
402626013009	catalytic residues [active]
402626013010	dimer interface [polypeptide binding]; other site
402626013011	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
402626013012	TMAO/DMSO reductase; Reviewed; Region: PRK05363
402626013013	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
402626013014	Moco binding site; other site
402626013015	metal coordination site [ion binding]; other site
402626013016	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
402626013017	RNA polymerase sigma factor; Provisional; Region: PRK12547
402626013018	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
402626013019	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
402626013020	DNA binding residues [nucleotide binding]
402626013021	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
402626013022	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
402626013023	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
402626013024	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
402626013025	ResB-like family; Region: ResB; pfam05140
402626013026	Cytochrome c553 [Energy production and conversion]; Region: COG2863
402626013027	Cytochrome c; Region: Cytochrom_C; cl11414
402626013028	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
402626013029	G1 box; other site
402626013030	GTP/Mg2+ binding site [chemical binding]; other site
402626013031	Switch I region; other site
402626013032	G2 box; other site
402626013033	G3 box; other site
402626013034	Switch II region; other site
402626013035	G4 box; other site
402626013036	G5 box; other site
402626013037	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
402626013038	dimer interface [polypeptide binding]; other site
402626013039	active site
402626013040	aspartate-rich active site metal binding site; other site
402626013041	allosteric magnesium binding site [ion binding]; other site
402626013042	Schiff base residues; other site
402626013043	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
402626013044	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
402626013045	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
402626013046	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
402626013047	DsbD alpha interface [polypeptide binding]; other site
402626013048	catalytic residues [active]
402626013049	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
402626013050	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
402626013051	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
402626013052	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
402626013053	alphaNTD homodimer interface [polypeptide binding]; other site
402626013054	alphaNTD - beta interaction site [polypeptide binding]; other site
402626013055	alphaNTD - beta' interaction site [polypeptide binding]; other site
402626013056	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
402626013057	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
402626013058	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
402626013059	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
402626013060	RNA binding surface [nucleotide binding]; other site
402626013061	30S ribosomal protein S11; Validated; Region: PRK05309
402626013062	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
402626013063	30S ribosomal protein S13; Region: bact_S13; TIGR03631
402626013064	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
402626013065	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
402626013066	rRNA binding site [nucleotide binding]; other site
402626013067	predicted 30S ribosome binding site; other site
402626013068	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
402626013069	SecY translocase; Region: SecY; pfam00344
402626013070	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
402626013071	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
402626013072	23S rRNA binding site [nucleotide binding]; other site
402626013073	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
402626013074	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
402626013075	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
402626013076	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
402626013077	5S rRNA interface [nucleotide binding]; other site
402626013078	23S rRNA interface [nucleotide binding]; other site
402626013079	L5 interface [polypeptide binding]; other site
402626013080	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
402626013081	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
402626013082	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
402626013083	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
402626013084	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
402626013085	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
402626013086	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
402626013087	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
402626013088	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
402626013089	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
402626013090	RNA binding site [nucleotide binding]; other site
402626013091	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
402626013092	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
402626013093	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
402626013094	23S rRNA interface [nucleotide binding]; other site
402626013095	putative translocon interaction site; other site
402626013096	signal recognition particle (SRP54) interaction site; other site
402626013097	L23 interface [polypeptide binding]; other site
402626013098	trigger factor interaction site; other site
402626013099	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
402626013100	23S rRNA interface [nucleotide binding]; other site
402626013101	5S rRNA interface [nucleotide binding]; other site
402626013102	putative antibiotic binding site [chemical binding]; other site
402626013103	L25 interface [polypeptide binding]; other site
402626013104	L27 interface [polypeptide binding]; other site
402626013105	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
402626013106	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
402626013107	G-X-X-G motif; other site
402626013108	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
402626013109	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
402626013110	putative translocon binding site; other site
402626013111	protein-rRNA interface [nucleotide binding]; other site
402626013112	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
402626013113	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
402626013114	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
402626013115	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
402626013116	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
402626013117	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
402626013118	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
402626013119	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
402626013120	elongation factor Tu; Reviewed; Region: PRK00049
402626013121	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
402626013122	G1 box; other site
402626013123	GEF interaction site [polypeptide binding]; other site
402626013124	GTP/Mg2+ binding site [chemical binding]; other site
402626013125	Switch I region; other site
402626013126	G2 box; other site
402626013127	G3 box; other site
402626013128	Switch II region; other site
402626013129	G4 box; other site
402626013130	G5 box; other site
402626013131	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
402626013132	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
402626013133	Antibiotic Binding Site [chemical binding]; other site
402626013134	elongation factor G; Reviewed; Region: PRK00007
402626013135	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
402626013136	G1 box; other site
402626013137	putative GEF interaction site [polypeptide binding]; other site
402626013138	GTP/Mg2+ binding site [chemical binding]; other site
402626013139	Switch I region; other site
402626013140	G2 box; other site
402626013141	G3 box; other site
402626013142	Switch II region; other site
402626013143	G4 box; other site
402626013144	G5 box; other site
402626013145	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
402626013146	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
402626013147	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
402626013148	30S ribosomal protein S7; Validated; Region: PRK05302
402626013149	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
402626013150	S17 interaction site [polypeptide binding]; other site
402626013151	S8 interaction site; other site
402626013152	16S rRNA interaction site [nucleotide binding]; other site
402626013153	streptomycin interaction site [chemical binding]; other site
402626013154	23S rRNA interaction site [nucleotide binding]; other site
402626013155	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
402626013156	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
402626013157	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
402626013158	LysR family transcriptional regulator; Provisional; Region: PRK14997
402626013159	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626013160	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626013161	putative effector binding pocket; other site
402626013162	dimerization interface [polypeptide binding]; other site
402626013163	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
402626013164	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
402626013165	ATP binding site [chemical binding]; other site
402626013166	putative Mg++ binding site [ion binding]; other site
402626013167	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
402626013168	nucleotide binding region [chemical binding]; other site
402626013169	ATP-binding site [chemical binding]; other site
402626013170	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
402626013171	HRDC domain; Region: HRDC; pfam00570
402626013172	Methyltransferase domain; Region: Methyltransf_23; pfam13489
402626013173	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626013174	S-adenosylmethionine binding site [chemical binding]; other site
402626013175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
402626013176	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
402626013177	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
402626013178	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
402626013179	Predicted secreted protein [Function unknown]; Region: COG5445
402626013180	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
402626013181	Predicted secreted protein [Function unknown]; Region: COG5445
402626013182	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
402626013183	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
402626013184	MG2 domain; Region: A2M_N; pfam01835
402626013185	Alpha-2-macroglobulin family; Region: A2M; pfam00207
402626013186	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
402626013187	Protein of unknown function (DUF1175); Region: DUF1175; cl14898
402626013188	Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; pfam09909
402626013189	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
402626013190	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
402626013191	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
402626013192	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
402626013193	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
402626013194	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
402626013195	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
402626013196	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
402626013197	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
402626013198	DNA binding site [nucleotide binding]
402626013199	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
402626013200	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
402626013201	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
402626013202	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
402626013203	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
402626013204	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
402626013205	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
402626013206	RPB3 interaction site [polypeptide binding]; other site
402626013207	RPB1 interaction site [polypeptide binding]; other site
402626013208	RPB11 interaction site [polypeptide binding]; other site
402626013209	RPB10 interaction site [polypeptide binding]; other site
402626013210	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
402626013211	core dimer interface [polypeptide binding]; other site
402626013212	peripheral dimer interface [polypeptide binding]; other site
402626013213	L10 interface [polypeptide binding]; other site
402626013214	L11 interface [polypeptide binding]; other site
402626013215	putative EF-Tu interaction site [polypeptide binding]; other site
402626013216	putative EF-G interaction site [polypeptide binding]; other site
402626013217	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
402626013218	23S rRNA interface [nucleotide binding]; other site
402626013219	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
402626013220	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
402626013221	mRNA/rRNA interface [nucleotide binding]; other site
402626013222	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
402626013223	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
402626013224	23S rRNA interface [nucleotide binding]; other site
402626013225	L7/L12 interface [polypeptide binding]; other site
402626013226	putative thiostrepton binding site; other site
402626013227	L25 interface [polypeptide binding]; other site
402626013228	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
402626013229	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
402626013230	putative homodimer interface [polypeptide binding]; other site
402626013231	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
402626013232	heterodimer interface [polypeptide binding]; other site
402626013233	homodimer interface [polypeptide binding]; other site
402626013234	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
402626013235	elongation factor Tu; Reviewed; Region: PRK00049
402626013236	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
402626013237	G1 box; other site
402626013238	GEF interaction site [polypeptide binding]; other site
402626013239	GTP/Mg2+ binding site [chemical binding]; other site
402626013240	Switch I region; other site
402626013241	G2 box; other site
402626013242	G3 box; other site
402626013243	Switch II region; other site
402626013244	G4 box; other site
402626013245	G5 box; other site
402626013246	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
402626013247	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
402626013248	Antibiotic Binding Site [chemical binding]; other site
402626013249	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
402626013250	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
402626013251	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
402626013252	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
402626013253	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
402626013254	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
402626013255	CHAD domain; Region: CHAD; cl10506
402626013256	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
402626013257	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
402626013258	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
402626013259	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
402626013260	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
402626013261	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
402626013262	Walker A/P-loop; other site
402626013263	ATP binding site [chemical binding]; other site
402626013264	Q-loop/lid; other site
402626013265	ABC transporter signature motif; other site
402626013266	Walker B; other site
402626013267	D-loop; other site
402626013268	H-loop/switch region; other site
402626013269	TOBE domain; Region: TOBE_2; pfam08402
402626013270	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
402626013271	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
402626013272	Walker A/P-loop; other site
402626013273	ATP binding site [chemical binding]; other site
402626013274	Q-loop/lid; other site
402626013275	ABC transporter signature motif; other site
402626013276	Walker B; other site
402626013277	D-loop; other site
402626013278	H-loop/switch region; other site
402626013279	TOBE domain; Region: TOBE_2; pfam08402
402626013280	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
402626013281	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626013282	dimer interface [polypeptide binding]; other site
402626013283	conserved gate region; other site
402626013284	putative PBP binding loops; other site
402626013285	ABC-ATPase subunit interface; other site
402626013286	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
402626013287	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626013288	dimer interface [polypeptide binding]; other site
402626013289	conserved gate region; other site
402626013290	putative PBP binding loops; other site
402626013291	ABC-ATPase subunit interface; other site
402626013292	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
402626013293	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
402626013294	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
402626013295	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
402626013296	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
402626013297	N- and C-terminal domain interface [polypeptide binding]; other site
402626013298	active site
402626013299	MgATP binding site [chemical binding]; other site
402626013300	catalytic site [active]
402626013301	metal binding site [ion binding]; metal-binding site
402626013302	glycerol binding site [chemical binding]; other site
402626013303	homotetramer interface [polypeptide binding]; other site
402626013304	homodimer interface [polypeptide binding]; other site
402626013305	FBP binding site [chemical binding]; other site
402626013306	protein IIAGlc interface [polypeptide binding]; other site
402626013307	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
402626013308	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
402626013309	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
402626013310	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
402626013311	dimerization interface [polypeptide binding]; other site
402626013312	putative active cleft [active]
402626013313	citrate-proton symporter; Provisional; Region: PRK15075
402626013314	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626013315	putative substrate translocation pore; other site
402626013316	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
402626013317	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
402626013318	putative ligand binding site [chemical binding]; other site
402626013319	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
402626013320	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
402626013321	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626013322	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
402626013323	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
402626013324	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
402626013325	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
402626013326	non-specific DNA binding site [nucleotide binding]; other site
402626013327	salt bridge; other site
402626013328	sequence-specific DNA binding site [nucleotide binding]; other site
402626013329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
402626013330	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
402626013331	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
402626013332	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
402626013333	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
402626013334	putative active site [active]
402626013335	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626013336	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626013337	trimer interface [polypeptide binding]; other site
402626013338	eyelet of channel; other site
402626013339	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
402626013340	Mechanosensitive ion channel; Region: MS_channel; pfam00924
402626013341	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
402626013342	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626013343	putative substrate translocation pore; other site
402626013344	glutathione s-transferase; Provisional; Region: PTZ00057
402626013345	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
402626013346	GSH binding site (G-site) [chemical binding]; other site
402626013347	C-terminal domain interface [polypeptide binding]; other site
402626013348	dimer interface [polypeptide binding]; other site
402626013349	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
402626013350	N-terminal domain interface [polypeptide binding]; other site
402626013351	dimer interface [polypeptide binding]; other site
402626013352	substrate binding pocket (H-site) [chemical binding]; other site
402626013353	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
402626013354	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
402626013355	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626013356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626013357	active site
402626013358	phosphorylation site [posttranslational modification]
402626013359	intermolecular recognition site; other site
402626013360	dimerization interface [polypeptide binding]; other site
402626013361	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626013362	DNA binding residues [nucleotide binding]
402626013363	dimerization interface [polypeptide binding]; other site
402626013364	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
402626013365	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626013366	substrate binding pocket [chemical binding]; other site
402626013367	membrane-bound complex binding site; other site
402626013368	hinge residues; other site
402626013369	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626013370	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
402626013371	substrate binding pocket [chemical binding]; other site
402626013372	membrane-bound complex binding site; other site
402626013373	hinge residues; other site
402626013374	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626013375	PAS domain; Region: PAS_9; pfam13426
402626013376	putative active site [active]
402626013377	heme pocket [chemical binding]; other site
402626013378	PAS domain; Region: PAS_9; pfam13426
402626013379	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626013380	putative active site [active]
402626013381	heme pocket [chemical binding]; other site
402626013382	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626013383	dimer interface [polypeptide binding]; other site
402626013384	phosphorylation site [posttranslational modification]
402626013385	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626013386	ATP binding site [chemical binding]; other site
402626013387	Mg2+ binding site [ion binding]; other site
402626013388	G-X-G motif; other site
402626013389	Response regulator receiver domain; Region: Response_reg; pfam00072
402626013390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626013391	active site
402626013392	phosphorylation site [posttranslational modification]
402626013393	intermolecular recognition site; other site
402626013394	dimerization interface [polypeptide binding]; other site
402626013395	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
402626013396	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
402626013397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
402626013398	short chain dehydrogenase; Provisional; Region: PRK05650
402626013399	NAD(P) binding site [chemical binding]; other site
402626013400	active site
402626013401	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
402626013402	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
402626013403	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
402626013404	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
402626013405	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
402626013406	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
402626013407	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
402626013408	DNA binding residues [nucleotide binding]
402626013409	putative dimer interface [polypeptide binding]; other site
402626013410	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
402626013411	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
402626013412	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
402626013413	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626013414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626013415	homodimer interface [polypeptide binding]; other site
402626013416	catalytic residue [active]
402626013417	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
402626013418	High potential iron-sulfur protein; Region: HIPIP; pfam01355
402626013419	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
402626013420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626013421	active site
402626013422	phosphorylation site [posttranslational modification]
402626013423	intermolecular recognition site; other site
402626013424	dimerization interface [polypeptide binding]; other site
402626013425	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626013426	DNA binding site [nucleotide binding]
402626013427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
402626013428	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626013429	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626013430	trimer interface [polypeptide binding]; other site
402626013431	eyelet of channel; other site
402626013432	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
402626013433	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
402626013434	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
402626013435	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
402626013436	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
402626013437	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
402626013438	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
402626013439	catalytic loop [active]
402626013440	iron binding site [ion binding]; other site
402626013441	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
402626013442	glutamate carboxypeptidase; Reviewed; Region: PRK06133
402626013443	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
402626013444	metal binding site [ion binding]; metal-binding site
402626013445	dimer interface [polypeptide binding]; other site
402626013446	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
402626013447	Protein of unknown function; Region: DUF3658; pfam12395
402626013448	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
402626013449	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
402626013450	TrkA-N domain; Region: TrkA_N; pfam02254
402626013451	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
402626013452	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
402626013453	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626013454	Coenzyme A binding pocket [chemical binding]; other site
402626013455	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
402626013456	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626013457	putative DNA binding site [nucleotide binding]; other site
402626013458	putative Zn2+ binding site [ion binding]; other site
402626013459	AsnC family; Region: AsnC_trans_reg; pfam01037
402626013460	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
402626013461	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
402626013462	dimer interface [polypeptide binding]; other site
402626013463	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
402626013464	active site
402626013465	Fe binding site [ion binding]; other site
402626013466	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
402626013467	EF-hand domain pair; Region: EF_hand_5; pfam13499
402626013468	Ca2+ binding site [ion binding]; other site
402626013469	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
402626013470	EF-hand domain pair; Region: EF_hand_5; pfam13499
402626013471	Ca2+ binding site [ion binding]; other site
402626013472	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
402626013473	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
402626013474	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
402626013475	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
402626013476	Type II transport protein GspH; Region: GspH; pfam12019
402626013477	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
402626013478	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
402626013479	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
402626013480	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
402626013481	GspL periplasmic domain; Region: GspL_C; pfam12693
402626013482	Type II secretory pathway, component PulM [Intracellular trafficking and secretion]; Region: PulM; COG3149
402626013483	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
402626013484	type II secretion system protein D; Region: type_II_gspD; TIGR02517
402626013485	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
402626013486	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
402626013487	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
402626013488	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
402626013489	type II secretion system protein E; Region: type_II_gspE; TIGR02533
402626013490	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
402626013491	Walker A motif; other site
402626013492	ATP binding site [chemical binding]; other site
402626013493	Walker B motif; other site
402626013494	type II secretion system protein F; Region: GspF; TIGR02120
402626013495	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
402626013496	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
402626013497	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
402626013498	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
402626013499	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626013500	DNA-binding site [nucleotide binding]; DNA binding site
402626013501	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626013502	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626013503	homodimer interface [polypeptide binding]; other site
402626013504	catalytic residue [active]
402626013505	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
402626013506	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
402626013507	dimer interface [polypeptide binding]; other site
402626013508	PYR/PP interface [polypeptide binding]; other site
402626013509	TPP binding site [chemical binding]; other site
402626013510	substrate binding site [chemical binding]; other site
402626013511	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
402626013512	TPP-binding site; other site
402626013513	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
402626013514	exonuclease I; Provisional; Region: sbcB; PRK11779
402626013515	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
402626013516	active site
402626013517	catalytic site [active]
402626013518	substrate binding site [chemical binding]; other site
402626013519	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
402626013520	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
402626013521	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
402626013522	putative ligand binding site [chemical binding]; other site
402626013523	putative NAD binding site [chemical binding]; other site
402626013524	catalytic site [active]
402626013525	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
402626013526	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
402626013527	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
402626013528	ligand binding site [chemical binding]; other site
402626013529	flexible hinge region; other site
402626013530	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
402626013531	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
402626013532	dinuclear metal binding motif [ion binding]; other site
402626013533	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626013534	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626013535	trimer interface [polypeptide binding]; other site
402626013536	eyelet of channel; other site
402626013537	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626013538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626013539	active site
402626013540	phosphorylation site [posttranslational modification]
402626013541	intermolecular recognition site; other site
402626013542	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626013543	DNA binding residues [nucleotide binding]
402626013544	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626013545	dimerization interface [polypeptide binding]; other site
402626013546	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626013547	dimer interface [polypeptide binding]; other site
402626013548	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
402626013549	putative CheW interface [polypeptide binding]; other site
402626013550	Uncharacterized conserved protein [Function unknown]; Region: COG3868
402626013551	C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922
402626013552	putative active site [active]
402626013553	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
402626013554	classical (c) SDRs; Region: SDR_c; cd05233
402626013555	NAD(P) binding site [chemical binding]; other site
402626013556	active site
402626013557	MarR family; Region: MarR_2; cl17246
402626013558	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
402626013559	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626013560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626013561	active site
402626013562	phosphorylation site [posttranslational modification]
402626013563	intermolecular recognition site; other site
402626013564	dimerization interface [polypeptide binding]; other site
402626013565	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626013566	DNA binding residues [nucleotide binding]
402626013567	dimerization interface [polypeptide binding]; other site
402626013568	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
402626013569	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
402626013570	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
402626013571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626013572	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626013573	putative substrate translocation pore; other site
402626013574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626013575	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
402626013576	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
402626013577	active site
402626013578	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
402626013579	PAS domain; Region: PAS_9; pfam13426
402626013580	putative active site [active]
402626013581	heme pocket [chemical binding]; other site
402626013582	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
402626013583	Histidine kinase; Region: HisKA_3; pfam07730
402626013584	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
402626013585	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
402626013586	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
402626013587	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
402626013588	ring oligomerisation interface [polypeptide binding]; other site
402626013589	ATP/Mg binding site [chemical binding]; other site
402626013590	stacking interactions; other site
402626013591	hinge regions; other site
402626013592	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
402626013593	oligomerisation interface [polypeptide binding]; other site
402626013594	mobile loop; other site
402626013595	roof hairpin; other site
402626013596	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
402626013597	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
402626013598	putative dimer interface [polypeptide binding]; other site
402626013599	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
402626013600	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
402626013601	putative dimer interface [polypeptide binding]; other site
402626013602	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
402626013603	putative active site [active]
402626013604	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
402626013605	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
402626013606	EthD domain; Region: EthD; cl17553
402626013607	Dehydratase small subunit; Region: Dehydratase_SU; cl02055
402626013608	Transcriptional regulators [Transcription]; Region: MarR; COG1846
402626013609	MarR family; Region: MarR; pfam01047
402626013610	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
402626013611	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
402626013612	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
402626013613	substrate binding pocket [chemical binding]; other site
402626013614	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
402626013615	putative chaperone; Provisional; Region: PRK11678
402626013616	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
402626013617	nucleotide binding site [chemical binding]; other site
402626013618	putative NEF/HSP70 interaction site [polypeptide binding]; other site
402626013619	SBD interface [polypeptide binding]; other site
402626013620	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
402626013621	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
402626013622	active site
402626013623	metal binding site [ion binding]; metal-binding site
402626013624	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
402626013625	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
402626013626	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
402626013627	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
402626013628	catalytic residues [active]
402626013629	Uncharacterized conserved protein [Function unknown]; Region: COG1416
402626013630	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
402626013631	Predicted secreted protein [Function unknown]; Region: COG5501
402626013632	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
402626013633	Cytochrome c551/c552 [Energy production and conversion]; Region: COG4654
402626013634	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
402626013635	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
402626013636	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
402626013637	Cytochrome c; Region: Cytochrom_C; cl11414
402626013638	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
402626013639	BON domain; Region: BON; pfam04972
402626013640	bacterial OsmY and nodulation domain; Region: BON; smart00749
402626013641	hypothetical protein; Provisional; Region: PRK14673
402626013642	Predicted methyltransferases [General function prediction only]; Region: COG0313
402626013643	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
402626013644	putative SAM binding site [chemical binding]; other site
402626013645	putative homodimer interface [polypeptide binding]; other site
402626013646	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
402626013647	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
402626013648	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
402626013649	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
402626013650	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
402626013651	active site
402626013652	substrate binding site [chemical binding]; other site
402626013653	catalytic site [active]
402626013654	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
402626013655	ArsC family; Region: ArsC; pfam03960
402626013656	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
402626013657	M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697
402626013658	putative metal binding site [ion binding]; other site
402626013659	ureidoglycolate hydrolase; Provisional; Region: PRK03606
402626013660	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
402626013661	allantoicase; Provisional; Region: PRK13257
402626013662	Allantoicase repeat; Region: Allantoicase; pfam03561
402626013663	Allantoicase repeat; Region: Allantoicase; pfam03561
402626013664	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
402626013665	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
402626013666	Transcriptional regulators [Transcription]; Region: GntR; COG1802
402626013667	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626013668	DNA-binding site [nucleotide binding]; DNA binding site
402626013669	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
402626013670	Uncharacterized conserved protein [Function unknown]; Region: COG1739
402626013671	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
402626013672	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
402626013673	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626013674	transcriptional activator TtdR; Provisional; Region: PRK09801
402626013675	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626013676	putative effector binding pocket; other site
402626013677	dimerization interface [polypeptide binding]; other site
402626013678	glyoxylate carboligase; Provisional; Region: PRK11269
402626013679	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
402626013680	PYR/PP interface [polypeptide binding]; other site
402626013681	dimer interface [polypeptide binding]; other site
402626013682	TPP binding site [chemical binding]; other site
402626013683	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
402626013684	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
402626013685	TPP-binding site [chemical binding]; other site
402626013686	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
402626013687	tartronate semialdehyde reductase; Provisional; Region: PRK15059
402626013688	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
402626013689	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
402626013690	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
402626013691	MOFRL family; Region: MOFRL; pfam05161
402626013692	pyruvate kinase; Provisional; Region: PRK06247
402626013693	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
402626013694	domain interfaces; other site
402626013695	active site
402626013696	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
402626013697	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
402626013698	FeS/SAM binding site; other site
402626013699	HemN C-terminal domain; Region: HemN_C; pfam06969
402626013700	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
402626013701	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
402626013702	putative ligand binding site [chemical binding]; other site
402626013703	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
402626013704	Part of AAA domain; Region: AAA_19; pfam13245
402626013705	Family description; Region: UvrD_C_2; pfam13538
402626013706	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
402626013707	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
402626013708	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
402626013709	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
402626013710	lipoyl attachment site [posttranslational modification]; other site
402626013711	glycine dehydrogenase; Provisional; Region: PRK05367
402626013712	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
402626013713	tetramer interface [polypeptide binding]; other site
402626013714	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626013715	catalytic residue [active]
402626013716	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
402626013717	tetramer interface [polypeptide binding]; other site
402626013718	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626013719	catalytic residue [active]
402626013720	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
402626013721	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
402626013722	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
402626013723	Predicted membrane protein [Function unknown]; Region: COG1297
402626013724	putative oligopeptide transporter, OPT family; Region: TIGR00733
402626013725	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
402626013726	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
402626013727	Coenzyme A binding pocket [chemical binding]; other site
402626013728	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
402626013729	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
402626013730	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
402626013731	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
402626013732	dimerization interface [polypeptide binding]; other site
402626013733	ligand binding site [chemical binding]; other site
402626013734	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
402626013735	Predicted transcriptional regulator [Transcription]; Region: COG3905
402626013736	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
402626013737	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
402626013738	Glutamate binding site [chemical binding]; other site
402626013739	NAD binding site [chemical binding]; other site
402626013740	catalytic residues [active]
402626013741	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
402626013742	primosome assembly protein PriA; Validated; Region: PRK05580
402626013743	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
402626013744	ATP binding site [chemical binding]; other site
402626013745	putative Mg++ binding site [ion binding]; other site
402626013746	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
402626013747	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
402626013748	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
402626013749	substrate binding site [chemical binding]; other site
402626013750	active site
402626013751	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
402626013752	Uncharacterized conserved protein [Function unknown]; Region: COG3791
402626013753	Cache domain; Region: Cache_1; pfam02743
402626013754	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626013755	dimerization interface [polypeptide binding]; other site
402626013756	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
402626013757	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
402626013758	dimer interface [polypeptide binding]; other site
402626013759	putative CheW interface [polypeptide binding]; other site
402626013760	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
402626013761	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
402626013762	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626013763	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626013764	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626013765	dimerization interface [polypeptide binding]; other site
402626013766	glutathionine S-transferase; Provisional; Region: PRK10542
402626013767	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
402626013768	C-terminal domain interface [polypeptide binding]; other site
402626013769	GSH binding site (G-site) [chemical binding]; other site
402626013770	dimer interface [polypeptide binding]; other site
402626013771	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
402626013772	N-terminal domain interface [polypeptide binding]; other site
402626013773	dimer interface [polypeptide binding]; other site
402626013774	substrate binding pocket (H-site) [chemical binding]; other site
402626013775	PBP superfamily domain; Region: PBP_like_2; cl17296
402626013776	Protein of unknown function (DUF3562); Region: DUF3562; pfam12085
402626013777	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
402626013778	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
402626013779	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
402626013780	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
402626013781	FecR protein; Region: FecR; pfam04773
402626013782	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
402626013783	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
402626013784	gamma subunit interface [polypeptide binding]; other site
402626013785	epsilon subunit interface [polypeptide binding]; other site
402626013786	LBP interface [polypeptide binding]; other site
402626013787	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
402626013788	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
402626013789	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
402626013790	alpha subunit interaction interface [polypeptide binding]; other site
402626013791	Walker A motif; other site
402626013792	ATP binding site [chemical binding]; other site
402626013793	Walker B motif; other site
402626013794	inhibitor binding site; inhibition site
402626013795	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
402626013796	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
402626013797	core domain interface [polypeptide binding]; other site
402626013798	delta subunit interface [polypeptide binding]; other site
402626013799	epsilon subunit interface [polypeptide binding]; other site
402626013800	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
402626013801	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
402626013802	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
402626013803	beta subunit interaction interface [polypeptide binding]; other site
402626013804	Walker A motif; other site
402626013805	ATP binding site [chemical binding]; other site
402626013806	Walker B motif; other site
402626013807	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
402626013808	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
402626013809	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
402626013810	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
402626013811	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
402626013812	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
402626013813	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
402626013814	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
402626013815	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
402626013816	ParB-like nuclease domain; Region: ParB; smart00470
402626013817	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
402626013818	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
402626013819	P-loop; other site
402626013820	Magnesium ion binding site [ion binding]; other site
402626013821	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
402626013822	Magnesium ion binding site [ion binding]; other site
402626013823	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
402626013824	Putative methyltransferase; Region: Methyltransf_16; pfam10294
402626013825	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626013826	S-adenosylmethionine binding site [chemical binding]; other site
402626013827	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
402626013828	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
402626013829	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
402626013830	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
402626013831	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
402626013832	putative ligand binding site [chemical binding]; other site
402626013833	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
402626013834	putative NAD(P) binding site [chemical binding]; other site
402626013835	homodimer interface [polypeptide binding]; other site
402626013836	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
402626013837	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626013838	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626013839	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626013840	dimerization interface [polypeptide binding]; other site
402626013841	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
402626013842	atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229
402626013843	putative NAD(P) binding site [chemical binding]; other site
402626013844	putative active site [active]
402626013845	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
402626013846	Cupin domain; Region: Cupin_2; cl17218
402626013847	hypothetical protein; Provisional; Region: PRK10621
402626013848	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
402626013849	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
402626013850	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
402626013851	TM-ABC transporter signature motif; other site
402626013852	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
402626013853	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
402626013854	TM-ABC transporter signature motif; other site
402626013855	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
402626013856	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
402626013857	putative ligand binding site [chemical binding]; other site
402626013858	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
402626013859	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
402626013860	Walker A/P-loop; other site
402626013861	ATP binding site [chemical binding]; other site
402626013862	Q-loop/lid; other site
402626013863	ABC transporter signature motif; other site
402626013864	Walker B; other site
402626013865	D-loop; other site
402626013866	H-loop/switch region; other site
402626013867	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
402626013868	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
402626013869	Walker A/P-loop; other site
402626013870	ATP binding site [chemical binding]; other site
402626013871	Q-loop/lid; other site
402626013872	ABC transporter signature motif; other site
402626013873	Walker B; other site
402626013874	D-loop; other site
402626013875	H-loop/switch region; other site
402626013876	choline dehydrogenase; Validated; Region: PRK02106
402626013877	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
402626013878	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
402626013879	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
402626013880	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
402626013881	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
402626013882	DNA binding residues [nucleotide binding]
402626013883	dimer interface [polypeptide binding]; other site
402626013884	copper binding site [ion binding]; other site
402626013885	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
402626013886	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
402626013887	metal-binding site [ion binding]
402626013888	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626013889	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
402626013890	motif II; other site
402626013891	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
402626013892	metal-binding site [ion binding]
402626013893	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
402626013894	ornithine cyclodeaminase; Validated; Region: PRK07340
402626013895	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
402626013896	Predicted membrane protein [Function unknown]; Region: COG3714
402626013897	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
402626013898	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
402626013899	AsnC family; Region: AsnC_trans_reg; pfam01037
402626013900	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
402626013901	cofactor binding site; other site
402626013902	metal binding site [ion binding]; metal-binding site
402626013903	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
402626013904	aromatic arch; other site
402626013905	DCoH dimer interaction site [polypeptide binding]; other site
402626013906	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
402626013907	DCoH tetramer interaction site [polypeptide binding]; other site
402626013908	substrate binding site [chemical binding]; other site
402626013909	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
402626013910	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
402626013911	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626013912	active site
402626013913	phosphorylation site [posttranslational modification]
402626013914	intermolecular recognition site; other site
402626013915	dimerization interface [polypeptide binding]; other site
402626013916	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626013917	DNA binding site [nucleotide binding]
402626013918	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
402626013919	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626013920	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626013921	dimer interface [polypeptide binding]; other site
402626013922	phosphorylation site [posttranslational modification]
402626013923	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626013924	ATP binding site [chemical binding]; other site
402626013925	Mg2+ binding site [ion binding]; other site
402626013926	G-X-G motif; other site
402626013927	Proteins containing SET domain [General function prediction only]; Region: COG2940
402626013928	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
402626013929	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
402626013930	IHF dimer interface [polypeptide binding]; other site
402626013931	IHF - DNA interface [nucleotide binding]; other site
402626013932	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4322
402626013933	aldolase II superfamily protein; Provisional; Region: PRK07044
402626013934	intersubunit interface [polypeptide binding]; other site
402626013935	active site
402626013936	Zn2+ binding site [ion binding]; other site
402626013937	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
402626013938	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
402626013939	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
402626013940	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
402626013941	Sel1 repeat; Region: Sel1; cl02723
402626013942	Sel1-like repeats; Region: SEL1; smart00671
402626013943	Sel1-like repeats; Region: SEL1; smart00671
402626013944	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
402626013945	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
402626013946	active site
402626013947	metal binding site [ion binding]; metal-binding site
402626013948	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
402626013949	septum formation inhibitor; Reviewed; Region: PRK01973
402626013950	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
402626013951	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
402626013952	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
402626013953	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
402626013954	Switch I; other site
402626013955	Switch II; other site
402626013956	cell division topological specificity factor MinE; Provisional; Region: PRK13989
402626013957	Helix-turn-helix domain; Region: HTH_17; pfam12728
402626013958	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
402626013959	dimer interface [polypeptide binding]; other site
402626013960	active site
402626013961	coenzyme A binding site [chemical binding]; other site
402626013962	citrylCoA binding site [chemical binding]; other site
402626013963	Citrate synthase; Region: Citrate_synt; pfam00285
402626013964	oxalacetate/citrate binding site [chemical binding]; other site
402626013965	catalytic triad [active]
402626013966	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
402626013967	CoA-transferase family III; Region: CoA_transf_3; pfam02515
402626013968	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
402626013969	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
402626013970	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
402626013971	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
402626013972	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626013973	dimer interface [polypeptide binding]; other site
402626013974	conserved gate region; other site
402626013975	putative PBP binding loops; other site
402626013976	ABC-ATPase subunit interface; other site
402626013977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
402626013978	dimer interface [polypeptide binding]; other site
402626013979	conserved gate region; other site
402626013980	putative PBP binding loops; other site
402626013981	ABC-ATPase subunit interface; other site
402626013982	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
402626013983	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
402626013984	Walker A/P-loop; other site
402626013985	ATP binding site [chemical binding]; other site
402626013986	Q-loop/lid; other site
402626013987	ABC transporter signature motif; other site
402626013988	Walker B; other site
402626013989	D-loop; other site
402626013990	H-loop/switch region; other site
402626013991	Uncharacterized conserved protein [Function unknown]; Region: COG4754
402626013992	poly(beta-D-mannuronate) lyase; Provisional; Region: algL; PRK00325
402626013993	active site
402626013994	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
402626013995	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
402626013996	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
402626013997	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
402626013998	Chromate transporter; Region: Chromate_transp; pfam02417
402626013999	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
402626014000	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
402626014001	dimerization interface [polypeptide binding]; other site
402626014002	putative DNA binding site [nucleotide binding]; other site
402626014003	putative Zn2+ binding site [ion binding]; other site
402626014004	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
402626014005	putative metal binding site [ion binding]; other site
402626014006	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
402626014007	Low molecular weight phosphatase family; Region: LMWPc; cd00115
402626014008	active site
402626014009	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
402626014010	amphipathic channel; other site
402626014011	Asn-Pro-Ala signature motifs; other site
402626014012	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
402626014013	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
402626014014	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
402626014015	synthetase active site [active]
402626014016	NTP binding site [chemical binding]; other site
402626014017	metal binding site [ion binding]; metal-binding site
402626014018	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
402626014019	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
402626014020	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
402626014021	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
402626014022	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
402626014023	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
402626014024	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
402626014025	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
402626014026	Ligand Binding Site [chemical binding]; other site
402626014027	GAF domain; Region: GAF_3; pfam13492
402626014028	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626014029	dimer interface [polypeptide binding]; other site
402626014030	phosphorylation site [posttranslational modification]
402626014031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626014032	ATP binding site [chemical binding]; other site
402626014033	Mg2+ binding site [ion binding]; other site
402626014034	G-X-G motif; other site
402626014035	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
402626014036	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
402626014037	Response regulator receiver domain; Region: Response_reg; pfam00072
402626014038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626014039	active site
402626014040	phosphorylation site [posttranslational modification]
402626014041	intermolecular recognition site; other site
402626014042	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
402626014043	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626014044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626014045	active site
402626014046	phosphorylation site [posttranslational modification]
402626014047	intermolecular recognition site; other site
402626014048	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626014049	DNA binding residues [nucleotide binding]
402626014050	dimerization interface [polypeptide binding]; other site
402626014051	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
402626014052	amphipathic channel; other site
402626014053	Asn-Pro-Ala signature motifs; other site
402626014054	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
402626014055	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
402626014056	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
402626014057	salt bridge; other site
402626014058	non-specific DNA binding site [nucleotide binding]; other site
402626014059	sequence-specific DNA binding site [nucleotide binding]; other site
402626014060	Isochorismatase family; Region: Isochorismatase; pfam00857
402626014061	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
402626014062	catalytic triad [active]
402626014063	conserved cis-peptide bond; other site
402626014064	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
402626014065	CoenzymeA binding site [chemical binding]; other site
402626014066	subunit interaction site [polypeptide binding]; other site
402626014067	PHB binding site; other site
402626014068	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
402626014069	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
402626014070	trimer interface [polypeptide binding]; other site
402626014071	eyelet of channel; other site
402626014072	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
402626014073	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
402626014074	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
402626014075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626014076	active site
402626014077	phosphorylation site [posttranslational modification]
402626014078	intermolecular recognition site; other site
402626014079	dimerization interface [polypeptide binding]; other site
402626014080	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626014081	DNA binding site [nucleotide binding]
402626014082	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
402626014083	sensor protein QseC; Provisional; Region: PRK10337
402626014084	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
402626014085	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626014086	ATP binding site [chemical binding]; other site
402626014087	Mg2+ binding site [ion binding]; other site
402626014088	G-X-G motif; other site
402626014089	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
402626014090	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
402626014091	Transcriptional regulator; Region: Rrf2; cl17282
402626014092	Rrf2 family protein; Region: rrf2_super; TIGR00738
402626014093	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
402626014094	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
402626014095	heme-binding site [chemical binding]; other site
402626014096	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
402626014097	FAD binding pocket [chemical binding]; other site
402626014098	FAD binding motif [chemical binding]; other site
402626014099	phosphate binding motif [ion binding]; other site
402626014100	beta-alpha-beta structure motif; other site
402626014101	NAD binding pocket [chemical binding]; other site
402626014102	Heme binding  pocket [chemical binding]; other site
402626014103	NnrS protein; Region: NnrS; pfam05940
402626014104	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626014105	DNA-binding site [nucleotide binding]; DNA binding site
402626014106	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
402626014107	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626014108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626014109	homodimer interface [polypeptide binding]; other site
402626014110	catalytic residue [active]
402626014111	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
402626014112	Uncharacterized conserved protein [Function unknown]; Region: COG2128
402626014113	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626014114	Major Facilitator Superfamily; Region: MFS_1; pfam07690
402626014115	putative substrate translocation pore; other site
402626014116	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626014117	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626014118	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
402626014119	dimerization interface [polypeptide binding]; other site
402626014120	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
402626014121	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
402626014122	hypothetical protein; Provisional; Region: PRK11171
402626014123	Cupin domain; Region: Cupin_2; pfam07883
402626014124	Cupin domain; Region: Cupin_2; pfam07883
402626014125	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
402626014126	Homeodomain-like domain; Region: HTH_23; cl17451
402626014127	putative transposase OrfB; Reviewed; Region: PHA02517
402626014128	Integrase core domain; Region: rve; pfam00665
402626014129	Integrase core domain; Region: rve_3; pfam13683
402626014130	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
402626014131	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626014132	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
402626014133	putative homodimer-homodimer interface [polypeptide binding]; other site
402626014134	putative allosteric switch controlling residues; other site
402626014135	putative metal binding site [ion binding]; other site
402626014136	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
402626014137	EamA-like transporter family; Region: EamA; pfam00892
402626014138	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626014139	dimer interface [polypeptide binding]; other site
402626014140	phosphorylation site [posttranslational modification]
402626014141	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626014142	ATP binding site [chemical binding]; other site
402626014143	Mg2+ binding site [ion binding]; other site
402626014144	G-X-G motif; other site
402626014145	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
402626014146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626014147	active site
402626014148	phosphorylation site [posttranslational modification]
402626014149	intermolecular recognition site; other site
402626014150	dimerization interface [polypeptide binding]; other site
402626014151	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626014152	DNA binding site [nucleotide binding]
402626014153	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
402626014154	Ligand Binding Site [chemical binding]; other site
402626014155	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
402626014156	active site
402626014157	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
402626014158	Predicted transcriptional regulator [Transcription]; Region: COG2944
402626014159	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626014160	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626014161	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
402626014162	dimerization interface [polypeptide binding]; other site
402626014163	choline dehydrogenase; Validated; Region: PRK02106
402626014164	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
402626014165	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
402626014166	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
402626014167	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626014168	substrate binding pocket [chemical binding]; other site
402626014169	membrane-bound complex binding site; other site
402626014170	hinge residues; other site
402626014171	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
402626014172	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
402626014173	active site
402626014174	Autotransporter beta-domain; Region: Autotransporter; pfam03797
402626014175	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
402626014176	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
402626014177	FMN binding site [chemical binding]; other site
402626014178	substrate binding site [chemical binding]; other site
402626014179	putative catalytic residue [active]
402626014180	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
402626014181	ThiC-associated domain; Region: ThiC-associated; pfam13667
402626014182	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
402626014183	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
402626014184	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
402626014185	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
402626014186	thiS-thiF/thiG interaction site; other site
402626014187	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
402626014188	ThiS interaction site; other site
402626014189	putative active site [active]
402626014190	tetramer interface [polypeptide binding]; other site
402626014191	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
402626014192	thiamine phosphate binding site [chemical binding]; other site
402626014193	active site
402626014194	pyrophosphate binding site [ion binding]; other site
402626014195	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
402626014196	putative dimer interface [polypeptide binding]; other site
402626014197	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626014198	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
402626014199	dimer interface [polypeptide binding]; other site
402626014200	substrate binding site [chemical binding]; other site
402626014201	ATP binding site [chemical binding]; other site
402626014202	Alkaline phosphatase homologues; Region: alkPPc; smart00098
402626014203	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
402626014204	active site
402626014205	dimer interface [polypeptide binding]; other site
402626014206	Alkaline phosphatase homologues; Region: alkPPc; smart00098
402626014207	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
402626014208	active site
402626014209	dimer interface [polypeptide binding]; other site
402626014210	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
402626014211	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
402626014212	homotetramer interface [polypeptide binding]; other site
402626014213	ligand binding site [chemical binding]; other site
402626014214	catalytic site [active]
402626014215	NAD binding site [chemical binding]; other site
402626014216	Membrane protein of unknown function; Region: DUF360; cl00850
402626014217	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
402626014218	FAD binding site [chemical binding]; other site
402626014219	TfoX N-terminal domain; Region: TfoX_N; pfam04993
402626014220	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
402626014221	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
402626014222	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
402626014223	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
402626014224	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
402626014225	N-acetyl-D-glucosamine binding site [chemical binding]; other site
402626014226	catalytic residue [active]
402626014227	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
402626014228	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
402626014229	putative NAD(P) binding site [chemical binding]; other site
402626014230	active site
402626014231	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
402626014232	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
402626014233	putative C-terminal domain interface [polypeptide binding]; other site
402626014234	putative GSH binding site (G-site) [chemical binding]; other site
402626014235	putative dimer interface [polypeptide binding]; other site
402626014236	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
402626014237	putative N-terminal domain interface [polypeptide binding]; other site
402626014238	putative dimer interface [polypeptide binding]; other site
402626014239	putative substrate binding pocket (H-site) [chemical binding]; other site
402626014240	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
402626014241	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
402626014242	active site
402626014243	NTP binding site [chemical binding]; other site
402626014244	metal binding triad [ion binding]; metal-binding site
402626014245	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
402626014246	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
402626014247	Zn2+ binding site [ion binding]; other site
402626014248	Mg2+ binding site [ion binding]; other site
402626014249	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
402626014250	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
402626014251	substrate binding pocket [chemical binding]; other site
402626014252	membrane-bound complex binding site; other site
402626014253	hinge residues; other site
402626014254	Uncharacterized conserved protein [Function unknown]; Region: COG3246
402626014255	hypothetical protein; Provisional; Region: PRK07483
402626014256	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
402626014257	inhibitor-cofactor binding pocket; inhibition site
402626014258	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626014259	catalytic residue [active]
402626014260	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
402626014261	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
402626014262	putative active site [active]
402626014263	Response regulator receiver domain; Region: Response_reg; pfam00072
402626014264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626014265	active site
402626014266	phosphorylation site [posttranslational modification]
402626014267	intermolecular recognition site; other site
402626014268	dimerization interface [polypeptide binding]; other site
402626014269	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
402626014270	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
402626014271	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626014272	dimerization interface [polypeptide binding]; other site
402626014273	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626014274	dimer interface [polypeptide binding]; other site
402626014275	phosphorylation site [posttranslational modification]
402626014276	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626014277	ATP binding site [chemical binding]; other site
402626014278	Mg2+ binding site [ion binding]; other site
402626014279	G-X-G motif; other site
402626014280	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
402626014281	16S rRNA methyltransferase B; Provisional; Region: PRK10901
402626014282	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
402626014283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626014284	S-adenosylmethionine binding site [chemical binding]; other site
402626014285	M48 family peptidase; Provisional; Region: PRK03001
402626014286	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
402626014287	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
402626014288	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
402626014289	putative active site [active]
402626014290	substrate binding site [chemical binding]; other site
402626014291	putative cosubstrate binding site; other site
402626014292	catalytic site [active]
402626014293	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
402626014294	substrate binding site [chemical binding]; other site
402626014295	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
402626014296	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
402626014297	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
402626014298	active site
402626014299	catalytic residues [active]
402626014300	metal binding site [ion binding]; metal-binding site
402626014301	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
402626014302	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
402626014303	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
402626014304	DNA protecting protein DprA; Region: dprA; TIGR00732
402626014305	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
402626014306	catalytic residues [active]
402626014307	DNA topoisomerase III; Validated; Region: PRK08173
402626014308	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
402626014309	active site
402626014310	putative interdomain interaction site [polypeptide binding]; other site
402626014311	putative metal-binding site [ion binding]; other site
402626014312	putative nucleotide binding site [chemical binding]; other site
402626014313	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
402626014314	domain I; other site
402626014315	DNA binding groove [nucleotide binding]
402626014316	phosphate binding site [ion binding]; other site
402626014317	domain II; other site
402626014318	domain III; other site
402626014319	nucleotide binding site [chemical binding]; other site
402626014320	catalytic site [active]
402626014321	domain IV; other site
402626014322	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
402626014323	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
402626014324	Transcriptional regulator [Transcription]; Region: LysR; COG0583
402626014325	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
402626014326	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
402626014327	putative effector binding pocket; other site
402626014328	dimerization interface [polypeptide binding]; other site
402626014329	acyl-CoA synthetase; Validated; Region: PRK06178
402626014330	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
402626014331	acyl-activating enzyme (AAE) consensus motif; other site
402626014332	AMP binding site [chemical binding]; other site
402626014333	active site
402626014334	CoA binding site [chemical binding]; other site
402626014335	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
402626014336	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
402626014337	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
402626014338	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
402626014339	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
402626014340	rod shape-determining protein MreC; Provisional; Region: PRK13922
402626014341	rod shape-determining protein MreC; Region: MreC; pfam04085
402626014342	rod shape-determining protein MreB; Provisional; Region: PRK13927
402626014343	MreB and similar proteins; Region: MreB_like; cd10225
402626014344	nucleotide binding site [chemical binding]; other site
402626014345	Mg binding site [ion binding]; other site
402626014346	putative protofilament interaction site [polypeptide binding]; other site
402626014347	RodZ interaction site [polypeptide binding]; other site
402626014348	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
402626014349	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
402626014350	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
402626014351	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
402626014352	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
402626014353	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
402626014354	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
402626014355	GatB domain; Region: GatB_Yqey; smart00845
402626014356	Protein of unknown function, DUF484; Region: DUF484; cl17449
402626014357	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
402626014358	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
402626014359	active site
402626014360	Int/Topo IB signature motif; other site
402626014361	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
402626014362	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
402626014363	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
402626014364	putative RNA binding site [nucleotide binding]; other site
402626014365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626014366	S-adenosylmethionine binding site [chemical binding]; other site
402626014367	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
402626014368	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
402626014369	FAD binding domain; Region: FAD_binding_4; pfam01565
402626014370	Berberine and berberine like; Region: BBE; pfam08031
402626014371	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
402626014372	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
402626014373	metal binding site 2 [ion binding]; metal-binding site
402626014374	putative DNA binding helix; other site
402626014375	metal binding site 1 [ion binding]; metal-binding site
402626014376	structural Zn2+ binding site [ion binding]; other site
402626014377	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
402626014378	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
402626014379	P-loop, Walker A motif; other site
402626014380	Base recognition motif; other site
402626014381	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
402626014382	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
402626014383	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
402626014384	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
402626014385	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
402626014386	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
402626014387	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
402626014388	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
402626014389	active site
402626014390	HslU subunit interaction site [polypeptide binding]; other site
402626014391	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
402626014392	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626014393	Walker A motif; other site
402626014394	ATP binding site [chemical binding]; other site
402626014395	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626014396	Walker B motif; other site
402626014397	arginine finger; other site
402626014398	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
402626014399	CsbD-like; Region: CsbD; cl17424
402626014400	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
402626014401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626014402	active site
402626014403	phosphorylation site [posttranslational modification]
402626014404	intermolecular recognition site; other site
402626014405	dimerization interface [polypeptide binding]; other site
402626014406	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
402626014407	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626014408	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626014409	ATP binding site [chemical binding]; other site
402626014410	Mg2+ binding site [ion binding]; other site
402626014411	G-X-G motif; other site
402626014412	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
402626014413	Putative zinc-finger; Region: zf-HC2; pfam13490
402626014414	RNA polymerase sigma factor; Provisional; Region: PRK12520
402626014415	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
402626014416	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
402626014417	DNA binding residues [nucleotide binding]
402626014418	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
402626014419	feedback inhibition sensing region; other site
402626014420	homohexameric interface [polypeptide binding]; other site
402626014421	nucleotide binding site [chemical binding]; other site
402626014422	N-acetyl-L-glutamate binding site [chemical binding]; other site
402626014423	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
402626014424	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
402626014425	motif II; other site
402626014426	division inhibitor protein; Provisional; Region: slmA; PRK09480
402626014427	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626014428	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
402626014429	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626014430	DNA-binding site [nucleotide binding]; DNA binding site
402626014431	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
402626014432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626014433	homodimer interface [polypeptide binding]; other site
402626014434	catalytic residue [active]
402626014435	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
402626014436	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
402626014437	inhibitor-cofactor binding pocket; inhibition site
402626014438	pyridoxal 5'-phosphate binding site [chemical binding]; other site
402626014439	catalytic residue [active]
402626014440	succinic semialdehyde dehydrogenase; Region: PLN02278
402626014441	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
402626014442	tetramerization interface [polypeptide binding]; other site
402626014443	NAD(P) binding site [chemical binding]; other site
402626014444	catalytic residues [active]
402626014445	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
402626014446	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
402626014447	Methyltransferase domain; Region: Methyltransf_23; pfam13489
402626014448	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
402626014449	S-adenosylmethionine binding site [chemical binding]; other site
402626014450	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
402626014451	Sel1 repeat; Region: Sel1; cl02723
402626014452	Sel1-like repeats; Region: SEL1; smart00671
402626014453	Sel1-like repeats; Region: SEL1; smart00671
402626014454	Sel1-like repeats; Region: SEL1; smart00671
402626014455	Protein of unknown function (DUF466); Region: DUF466; pfam04328
402626014456	carbon starvation protein A; Provisional; Region: PRK15015
402626014457	Carbon starvation protein CstA; Region: CstA; pfam02554
402626014458	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
402626014459	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
402626014460	Cache domain; Region: Cache_2; pfam08269
402626014461	Histidine kinase; Region: HisKA_3; pfam07730
402626014462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626014463	ATP binding site [chemical binding]; other site
402626014464	Mg2+ binding site [ion binding]; other site
402626014465	G-X-G motif; other site
402626014466	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
402626014467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626014468	active site
402626014469	phosphorylation site [posttranslational modification]
402626014470	intermolecular recognition site; other site
402626014471	dimerization interface [polypeptide binding]; other site
402626014472	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626014473	DNA binding residues [nucleotide binding]
402626014474	dimerization interface [polypeptide binding]; other site
402626014475	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
402626014476	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
402626014477	putative NAD(P) binding site [chemical binding]; other site
402626014478	active site
402626014479	putative substrate binding site [chemical binding]; other site
402626014480	Transcriptional regulators [Transcription]; Region: FadR; COG2186
402626014481	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
402626014482	DNA-binding site [nucleotide binding]; DNA binding site
402626014483	FCD domain; Region: FCD; pfam07729
402626014484	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
402626014485	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
402626014486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
402626014487	putative aldolase; Validated; Region: PRK08130
402626014488	intersubunit interface [polypeptide binding]; other site
402626014489	active site
402626014490	Zn2+ binding site [ion binding]; other site
402626014491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
402626014492	D-galactonate transporter; Region: 2A0114; TIGR00893
402626014493	putative substrate translocation pore; other site
402626014494	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
402626014495	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
402626014496	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626014497	active site
402626014498	phosphorylation site [posttranslational modification]
402626014499	intermolecular recognition site; other site
402626014500	dimerization interface [polypeptide binding]; other site
402626014501	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
402626014502	DNA binding site [nucleotide binding]
402626014503	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
402626014504	active site
402626014505	substrate-binding site [chemical binding]; other site
402626014506	metal-binding site [ion binding]
402626014507	GTP binding site [chemical binding]; other site
402626014508	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
402626014509	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
402626014510	dimerization interface [polypeptide binding]; other site
402626014511	NAD binding site [chemical binding]; other site
402626014512	ligand binding site [chemical binding]; other site
402626014513	catalytic site [active]
402626014514	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
402626014515	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
402626014516	putative active site [active]
402626014517	metal binding site [ion binding]; metal-binding site
402626014518	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
402626014519	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
402626014520	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
402626014521	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
402626014522	Patatin-like phospholipase; Region: Patatin; pfam01734
402626014523	active site
402626014524	nucleophile elbow; other site
402626014525	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
402626014526	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
402626014527	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
402626014528	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
402626014529	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626014530	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
402626014531	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626014532	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
402626014533	Protein export membrane protein; Region: SecD_SecF; cl14618
402626014534	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
402626014535	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
402626014536	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
402626014537	active site
402626014538	DNA binding site [nucleotide binding]
402626014539	Int/Topo IB signature motif; other site
402626014540	catalytic residues [active]
402626014541	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
402626014542	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
402626014543	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
402626014544	nudix motif; other site
402626014545	nudix motif; other site
402626014546	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
402626014547	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
402626014548	trmE is a tRNA modification GTPase; Region: trmE; cd04164
402626014549	G1 box; other site
402626014550	GTP/Mg2+ binding site [chemical binding]; other site
402626014551	Switch I region; other site
402626014552	G2 box; other site
402626014553	Switch II region; other site
402626014554	G3 box; other site
402626014555	G4 box; other site
402626014556	G5 box; other site
402626014557	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
402626014558	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
402626014559	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
402626014560	membrane protein insertase; Provisional; Region: PRK01318
402626014561	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
402626014562	hypothetical protein; Validated; Region: PRK00041
402626014563	Ribonuclease P; Region: Ribonuclease_P; cl00457
402626014564	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
402626014565	PemK-like protein; Region: PemK; pfam02452
402626014566	Phage integrase protein; Region: DUF3701; pfam12482
402626014567	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
402626014568	active site
402626014569	catalytic residues [active]
402626014570	DNA binding site [nucleotide binding]
402626014571	Int/Topo IB signature motif; other site
402626014572	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
402626014573	ParG; Region: ParG; pfam09274
402626014574	ParA-like protein; Provisional; Region: PHA02518
402626014575	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
402626014576	P-loop; other site
402626014577	Magnesium ion binding site [ion binding]; other site
402626014578	Initiator Replication protein; Region: Rep_3; pfam01051
402626014579	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
402626014580	AAA-like domain; Region: AAA_10; pfam12846
402626014581	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
402626014582	Walker B motif; other site
402626014583	Methyltransferase domain; Region: Methyltransf_27; pfam13708
402626014584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
402626014585	Walker A motif; other site
402626014586	ATP binding site [chemical binding]; other site
402626014587	Walker B motif; other site
402626014588	arginine finger; other site
402626014589	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
402626014590	putative active site [active]
402626014591	putative metal binding site [ion binding]; other site
402626014592	Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505
402626014593	LexA repressor; Validated; Region: PRK00215
402626014594	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
402626014595	Catalytic site [active]
402626014596	TniQ; Region: TniQ; pfam06527
402626014597	Bacterial TniB protein; Region: TniB; pfam05621
402626014598	AAA domain; Region: AAA_22; pfam13401
402626014599	Integrase core domain; Region: rve; pfam00665
402626014600	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
402626014601	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
402626014602	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
402626014603	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
402626014604	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
402626014605	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
402626014606	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
402626014607	dimerization interface [polypeptide binding]; other site
402626014608	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
402626014609	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
402626014610	dimer interface [polypeptide binding]; other site
402626014611	phosphorylation site [posttranslational modification]
402626014612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
402626014613	ATP binding site [chemical binding]; other site
402626014614	Mg2+ binding site [ion binding]; other site
402626014615	G-X-G motif; other site
402626014616	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
402626014617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
402626014618	active site
402626014619	phosphorylation site [posttranslational modification]
402626014620	intermolecular recognition site; other site
402626014621	dimerization interface [polypeptide binding]; other site
402626014622	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
402626014623	DNA binding residues [nucleotide binding]
402626014624	dimerization interface [polypeptide binding]; other site
402626014625	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
402626014626	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
402626014627	HlyD family secretion protein; Region: HlyD_3; pfam13437
402626014628	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
402626014629	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
402626014630	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
402626014631	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
402626014632	ParB-like nuclease domain; Region: ParBc; pfam02195
402626014633	Domain of unknown function (DUF932); Region: DUF932; pfam06067
402626014634	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
402626014635	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
402626014636	PLD-like domain; Region: PLDc_2; pfam13091
402626014637	putative active site [active]
402626014638	catalytic site [active]
402626014639	Protein of unknown function (DUF2274); Region: DUF2274; cl02406
402626014640	conjugal transfer protein TraB; Provisional; Region: PRK13825
402626014641	active site
402626014642	catalytic triad [active]
402626014643	dimer interface [polypeptide binding]; other site
402626014644	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
402626014645	VirB7 interaction site; other site
402626014646	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
402626014647	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
402626014648	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
402626014649	VirB7 interaction site; other site
402626014650	VirB8 protein; Region: VirB8; pfam04335
402626014651	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
402626014652	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
402626014653	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
402626014654	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
402626014655	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
402626014656	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
402626014657	Walker A motif; other site
402626014658	hexamer interface [polypeptide binding]; other site
402626014659	ATP binding site [chemical binding]; other site
402626014660	Walker B motif; other site
402626014661	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
402626014662	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
402626014663	N-acetyl-D-glucosamine binding site [chemical binding]; other site
402626014664	catalytic residue [active]
402626014665	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
402626014666	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
402626014667	dimer interface [polypeptide binding]; other site
402626014668	ssDNA binding site [nucleotide binding]; other site
402626014669	tetramer (dimer of dimers) interface [polypeptide binding]; other site
402626014670	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
402626014671	Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917
402626014672	PilS N terminal; Region: PilS; pfam08805
402626014673	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
402626014674	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
402626014675	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
402626014676	Walker A motif; other site
402626014677	ATP binding site [chemical binding]; other site
402626014678	Walker B motif; other site
402626014679	type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021
402626014680	type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520
402626014681	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
402626014682	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
402626014683	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
402626014684	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
402626014685	N-acetyl-D-glucosamine binding site [chemical binding]; other site
402626014686	catalytic residue [active]
402626014687	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
402626014688	VirB7 interaction site; other site
402626014689	Pleckstrin homology-like domain; Region: PH-like; cl17171