-- dump date   	20140620_023746
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
859657000001	ParA-like protein; Provisional; Region: PHA02518
859657000002	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
859657000003	P-loop; other site
859657000004	Magnesium ion binding site [ion binding]; other site
859657000005	HicB family; Region: HicB; pfam05534
859657000006	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
859657000007	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
859657000008	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
859657000009	stationary phase growth adaptation protein; Provisional; Region: PRK09717
859657000010	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
859657000011	Initiator Replication protein; Region: Rep_3; pfam01051
859657000012	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
859657000013	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
859657000014	DNA-binding site [nucleotide binding]; DNA binding site
859657000015	RNA-binding motif; other site
859657000016	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
859657000017	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
859657000018	P-loop; other site
859657000019	Magnesium ion binding site [ion binding]; other site
859657000020	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
859657000021	ParB-like nuclease domain; Region: ParBc; pfam02195
859657000022	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
859657000023	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
859657000024	active site
859657000025	tetramer interface; other site
859657000026	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
859657000027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657000028	putative substrate translocation pore; other site
859657000029	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
859657000030	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657000031	dimer interface [polypeptide binding]; other site
859657000032	phosphorylation site [posttranslational modification]
859657000033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657000034	ATP binding site [chemical binding]; other site
859657000035	Mg2+ binding site [ion binding]; other site
859657000036	G-X-G motif; other site
859657000037	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
859657000038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657000039	active site
859657000040	phosphorylation site [posttranslational modification]
859657000041	intermolecular recognition site; other site
859657000042	dimerization interface [polypeptide binding]; other site
859657000043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657000044	Walker A motif; other site
859657000045	ATP binding site [chemical binding]; other site
859657000046	Walker B motif; other site
859657000047	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859657000048	Predicted membrane protein [Function unknown]; Region: COG4377
859657000049	Cache domain; Region: Cache_1; pfam02743
859657000050	FOG: HAMP domain [Signal transduction mechanisms]; Region: ResE; COG2770
859657000051	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657000052	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
859657000053	putative active site [active]
859657000054	heme pocket [chemical binding]; other site
859657000055	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657000056	putative active site [active]
859657000057	heme pocket [chemical binding]; other site
859657000058	PAS fold; Region: PAS_4; pfam08448
859657000059	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657000060	putative active site [active]
859657000061	heme pocket [chemical binding]; other site
859657000062	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657000063	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657000064	metal binding site [ion binding]; metal-binding site
859657000065	active site
859657000066	I-site; other site
859657000067	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859657000068	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
859657000069	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859657000070	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859657000071	TM-ABC transporter signature motif; other site
859657000072	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859657000073	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859657000074	TM-ABC transporter signature motif; other site
859657000075	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859657000076	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859657000077	Walker A/P-loop; other site
859657000078	ATP binding site [chemical binding]; other site
859657000079	Q-loop/lid; other site
859657000080	ABC transporter signature motif; other site
859657000081	Walker B; other site
859657000082	D-loop; other site
859657000083	H-loop/switch region; other site
859657000084	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859657000085	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859657000086	Walker A/P-loop; other site
859657000087	ATP binding site [chemical binding]; other site
859657000088	Q-loop/lid; other site
859657000089	ABC transporter signature motif; other site
859657000090	Walker B; other site
859657000091	D-loop; other site
859657000092	H-loop/switch region; other site
859657000093	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657000094	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657000095	LysR substrate binding domain; Region: LysR_substrate; pfam03466
859657000096	dimerization interface [polypeptide binding]; other site
859657000097	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
859657000098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
859657000099	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
859657000100	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
859657000101	Cl- selectivity filter; other site
859657000102	Cl- binding residues [ion binding]; other site
859657000103	pore gating glutamate residue; other site
859657000104	dimer interface [polypeptide binding]; other site
859657000105	Protein of unknown function (DUF2731); Region: DUF2731; pfam10806
859657000106	Spherulation-specific family 4; Region: Spherulin4; pfam12138
859657000107	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
859657000108	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
859657000109	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859657000110	catalytic residue [active]
859657000111	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657000112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657000113	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
859657000114	dimerization interface [polypeptide binding]; other site
859657000115	substrate binding pocket [chemical binding]; other site
859657000116	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
859657000117	substrate binding site [chemical binding]; other site
859657000118	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
859657000119	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
859657000120	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
859657000121	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859657000122	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657000123	dimerization interface [polypeptide binding]; other site
859657000124	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657000125	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657000126	dimer interface [polypeptide binding]; other site
859657000127	phosphorylation site [posttranslational modification]
859657000128	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657000129	ATP binding site [chemical binding]; other site
859657000130	Mg2+ binding site [ion binding]; other site
859657000131	G-X-G motif; other site
859657000132	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859657000133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657000134	active site
859657000135	phosphorylation site [posttranslational modification]
859657000136	intermolecular recognition site; other site
859657000137	dimerization interface [polypeptide binding]; other site
859657000138	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657000139	DNA binding residues [nucleotide binding]
859657000140	dimerization interface [polypeptide binding]; other site
859657000141	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
859657000142	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657000143	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
859657000144	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657000145	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859657000146	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657000147	Leucine-rich repeats; other site
859657000148	Substrate binding site [chemical binding]; other site
859657000149	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657000150	chemotaxis regulator CheZ; Provisional; Region: PRK11166
859657000151	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
859657000152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657000153	active site
859657000154	phosphorylation site [posttranslational modification]
859657000155	intermolecular recognition site; other site
859657000156	dimerization interface [polypeptide binding]; other site
859657000157	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
859657000158	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859657000159	H-NS histone family; Region: Histone_HNS; pfam00816
859657000160	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
859657000161	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657000162	Coenzyme A binding pocket [chemical binding]; other site
859657000163	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
859657000164	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416
859657000165	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
859657000166	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859657000167	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859657000168	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
859657000169	active site
859657000170	FMN binding site [chemical binding]; other site
859657000171	substrate binding site [chemical binding]; other site
859657000172	homotetramer interface [polypeptide binding]; other site
859657000173	catalytic residue [active]
859657000174	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
859657000175	classical (c) SDRs; Region: SDR_c; cd05233
859657000176	NAD(P) binding site [chemical binding]; other site
859657000177	active site
859657000178	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859657000179	MarR family; Region: MarR; pfam01047
859657000180	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
859657000181	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657000182	substrate binding site [chemical binding]; other site
859657000183	oxyanion hole (OAH) forming residues; other site
859657000184	trimer interface [polypeptide binding]; other site
859657000185	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859657000186	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
859657000187	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859657000188	active site
859657000189	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657000190	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
859657000191	acyl-activating enzyme (AAE) consensus motif; other site
859657000192	AMP binding site [chemical binding]; other site
859657000193	active site
859657000194	CoA binding site [chemical binding]; other site
859657000195	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
859657000196	active site
859657000197	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
859657000198	homotrimer interaction site [polypeptide binding]; other site
859657000199	putative active site [active]
859657000200	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
859657000201	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
859657000202	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657000203	putative substrate translocation pore; other site
859657000204	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657000205	non-specific DNA binding site [nucleotide binding]; other site
859657000206	sequence-specific DNA binding site [nucleotide binding]; other site
859657000207	salt bridge; other site
859657000208	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3657
859657000209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657000210	putative substrate translocation pore; other site
859657000211	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
859657000212	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
859657000213	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657000214	DNA-binding site [nucleotide binding]; DNA binding site
859657000215	UTRA domain; Region: UTRA; pfam07702
859657000216	Predicted transcriptional regulators [Transcription]; Region: COG1733
859657000217	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
859657000218	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
859657000219	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859657000220	putative metal binding site [ion binding]; other site
859657000221	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657000222	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657000223	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
859657000224	putative dimerization interface [polypeptide binding]; other site
859657000225	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
859657000226	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859657000227	N-terminal plug; other site
859657000228	ligand-binding site [chemical binding]; other site
859657000229	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
859657000230	hydrophobic ligand binding site; other site
859657000231	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
859657000232	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
859657000233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657000234	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859657000235	putative substrate translocation pore; other site
859657000236	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657000237	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657000238	MoxR-like ATPases [General function prediction only]; Region: COG0714
859657000239	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657000240	ATP binding site [chemical binding]; other site
859657000241	Walker A motif; other site
859657000242	Walker B motif; other site
859657000243	arginine finger; other site
859657000244	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
859657000245	Protein of unknown function DUF58; Region: DUF58; pfam01882
859657000246	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
859657000247	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
859657000248	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
859657000249	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
859657000250	active site clefts [active]
859657000251	zinc binding site [ion binding]; other site
859657000252	dimer interface [polypeptide binding]; other site
859657000253	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
859657000254	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
859657000255	Sulfate transporter family; Region: Sulfate_transp; pfam00916
859657000256	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
859657000257	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859657000258	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859657000259	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859657000260	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
859657000261	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
859657000262	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
859657000263	substrate binding site [chemical binding]; other site
859657000264	ligand binding site [chemical binding]; other site
859657000265	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
859657000266	substrate binding site [chemical binding]; other site
859657000267	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
859657000268	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
859657000269	dimer interface [polypeptide binding]; other site
859657000270	active site
859657000271	citrylCoA binding site [chemical binding]; other site
859657000272	oxalacetate/citrate binding site [chemical binding]; other site
859657000273	coenzyme A binding site [chemical binding]; other site
859657000274	catalytic triad [active]
859657000275	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
859657000276	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
859657000277	tetramer interface [polypeptide binding]; other site
859657000278	active site
859657000279	Mg2+/Mn2+ binding site [ion binding]; other site
859657000280	Propionate catabolism activator; Region: PrpR_N; pfam06506
859657000281	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
859657000282	PAS domain; Region: PAS; smart00091
859657000283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657000284	Walker A motif; other site
859657000285	ATP binding site [chemical binding]; other site
859657000286	Walker B motif; other site
859657000287	arginine finger; other site
859657000288	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859657000289	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
859657000290	Nuclease-related domain; Region: NERD; pfam08378
859657000291	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
859657000292	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
859657000293	ATP binding site [chemical binding]; other site
859657000294	putative Mg++ binding site [ion binding]; other site
859657000295	Family description; Region: UvrD_C_2; pfam13538
859657000296	AAA domain; Region: AAA_23; pfam13476
859657000297	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657000298	AAA domain; Region: AAA_21; pfam13304
859657000299	Walker A/P-loop; other site
859657000300	ATP binding site [chemical binding]; other site
859657000301	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657000302	ABC transporter signature motif; other site
859657000303	Walker B; other site
859657000304	D-loop; other site
859657000305	H-loop/switch region; other site
859657000306	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859657000307	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859657000308	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859657000309	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859657000310	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859657000311	Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
859657000312	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657000313	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657000314	metal binding site [ion binding]; metal-binding site
859657000315	active site
859657000316	I-site; other site
859657000317	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859657000318	Predicted membrane protein [Function unknown]; Region: COG1289
859657000319	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
859657000320	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
859657000321	Cytochrome c [Energy production and conversion]; Region: COG3258
859657000322	Cytochrome c; Region: Cytochrom_C; pfam00034
859657000323	acyl-CoA thioesterase; Provisional; Region: PRK10531
859657000324	putative pectinesterase; Region: PLN02432; cl01911
859657000325	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657000326	Coenzyme A binding pocket [chemical binding]; other site
859657000327	PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287
859657000328	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
859657000329	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
859657000330	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
859657000331	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
859657000332	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
859657000333	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
859657000334	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
859657000335	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
859657000336	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
859657000337	acyl-activating enzyme (AAE) consensus motif; other site
859657000338	AMP binding site [chemical binding]; other site
859657000339	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657000340	Condensation domain; Region: Condensation; pfam00668
859657000341	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859657000342	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
859657000343	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
859657000344	acyl-activating enzyme (AAE) consensus motif; other site
859657000345	AMP binding site [chemical binding]; other site
859657000346	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657000347	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
859657000348	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
859657000349	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
859657000350	acyl-activating enzyme (AAE) consensus motif; other site
859657000351	AMP binding site [chemical binding]; other site
859657000352	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657000353	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
859657000354	ligand-binding site [chemical binding]; other site
859657000355	Evidence 4 : Homologs of previously reported genes of unknown function
859657000356	Evidence 4 : Homologs of previously reported genes of unknown function
859657000357	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
859657000358	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
859657000359	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
859657000360	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
859657000361	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
859657000362	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
859657000363	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
859657000364	putative hydrophobic ligand binding site [chemical binding]; other site
859657000365	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657000366	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657000367	aconitate hydratase; Provisional; Region: acnA; PRK12881
859657000368	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
859657000369	substrate binding site [chemical binding]; other site
859657000370	ligand binding site [chemical binding]; other site
859657000371	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
859657000372	substrate binding site [chemical binding]; other site
859657000373	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657000374	DNA-binding site [nucleotide binding]; DNA binding site
859657000375	Transcriptional regulators [Transcription]; Region: GntR; COG1802
859657000376	FCD domain; Region: FCD; pfam07729
859657000377	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
859657000378	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657000379	substrate binding pocket [chemical binding]; other site
859657000380	membrane-bound complex binding site; other site
859657000381	hinge residues; other site
859657000382	ATP-grasp domain; Region: ATP-grasp_4; cl17255
859657000383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657000384	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
859657000385	putative substrate translocation pore; other site
859657000386	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
859657000387	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
859657000388	active site
859657000389	catalytic tetrad [active]
859657000390	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657000391	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657000392	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
859657000393	putative effector binding pocket; other site
859657000394	putative dimerization interface [polypeptide binding]; other site
859657000395	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
859657000396	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859657000397	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
859657000398	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype
859657000399	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype
859657000400	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
859657000401	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
859657000402	dimer interface [polypeptide binding]; other site
859657000403	active site
859657000404	CoA binding pocket [chemical binding]; other site
859657000405	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
859657000406	chorismate mutase; Provisional; Region: PRK09269
859657000407	Chorismate mutase type II; Region: CM_2; cl00693
859657000408	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
859657000409	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
859657000410	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
859657000411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704
859657000412	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
859657000413	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
859657000414	AMP nucleosidase; Provisional; Region: PRK08292
859657000415	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
859657000416	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
859657000417	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
859657000418	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
859657000419	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
859657000420	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
859657000421	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
859657000422	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
859657000423	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
859657000424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859657000425	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859657000426	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859657000427	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859657000428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859657000429	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657000430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657000431	ATP binding site [chemical binding]; other site
859657000432	Mg2+ binding site [ion binding]; other site
859657000433	G-X-G motif; other site
859657000434	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
859657000435	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657000436	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
859657000437	substrate binding pocket [chemical binding]; other site
859657000438	dimerization interface [polypeptide binding]; other site
859657000439	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
859657000440	Rieske non-heme iron oxygenase (RO) family, Vanillate-O-demethylase oxygenase (VanA) and dicamba O-demethylase oxygenase (DdmC) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating...; Region: Rieske_RO_Alpha_VanA_DdmC; cd03532
859657000441	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
859657000442	alpha subunit interface [polypeptide binding]; other site
859657000443	active site
859657000444	substrate binding site [chemical binding]; other site
859657000445	Fe binding site [ion binding]; other site
859657000446	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
859657000447	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
859657000448	FMN-binding pocket [chemical binding]; other site
859657000449	flavin binding motif; other site
859657000450	phosphate binding motif [ion binding]; other site
859657000451	beta-alpha-beta structure motif; other site
859657000452	NAD binding pocket [chemical binding]; other site
859657000453	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657000454	catalytic loop [active]
859657000455	iron binding site [ion binding]; other site
859657000456	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859657000457	DNA binding site [nucleotide binding]
859657000458	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
859657000459	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
859657000460	putative ligand binding site [chemical binding]; other site
859657000461	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
859657000462	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859657000463	MarR family; Region: MarR; pfam01047
859657000464	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
859657000465	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657000466	substrate binding site [chemical binding]; other site
859657000467	oxyanion hole (OAH) forming residues; other site
859657000468	trimer interface [polypeptide binding]; other site
859657000469	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859657000470	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
859657000471	NAD(P) binding site [chemical binding]; other site
859657000472	catalytic residues [active]
859657000473	feruloyl-CoA synthase; Reviewed; Region: PRK08180
859657000474	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
859657000475	acyl-activating enzyme (AAE) consensus motif; other site
859657000476	putative AMP binding site [chemical binding]; other site
859657000477	putative active site [active]
859657000478	putative CoA binding site [chemical binding]; other site
859657000479	Activator of aromatic catabolism; Region: XylR_N; pfam06505
859657000480	V4R domain; Region: V4R; pfam02830
859657000481	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
859657000482	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657000483	Walker A motif; other site
859657000484	ATP binding site [chemical binding]; other site
859657000485	Walker B motif; other site
859657000486	arginine finger; other site
859657000487	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859657000488	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859657000489	NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
859657000490	NAD(P) binding site [chemical binding]; other site
859657000491	catalytic residues [active]
859657000492	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
859657000493	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657000494	NAD(P) binding site [chemical binding]; other site
859657000495	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
859657000496	active site
859657000497	Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313
859657000498	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
859657000499	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
859657000500	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859657000501	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859657000502	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859657000503	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859657000504	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859657000505	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859657000506	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
859657000507	Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
859657000508	Domain of unknown function (DUF1910); Region: DUF1910; pfam08928
859657000509	Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
859657000510	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
859657000511	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859657000512	active site
859657000513	benzoate transport; Region: 2A0115; TIGR00895
859657000514	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657000515	putative substrate translocation pore; other site
859657000516	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
859657000517	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
859657000518	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
859657000519	active site
859657000520	catalytic site [active]
859657000521	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
859657000522	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
859657000523	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
859657000524	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
859657000525	catalytic site [active]
859657000526	active site
859657000527	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
859657000528	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
859657000529	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
859657000530	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
859657000531	active site
859657000532	catalytic site [active]
859657000533	glycogen branching enzyme; Provisional; Region: PRK05402
859657000534	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
859657000535	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
859657000536	active site
859657000537	catalytic site [active]
859657000538	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
859657000539	trehalose synthase; Region: treS_nterm; TIGR02456
859657000540	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
859657000541	active site
859657000542	catalytic site [active]
859657000543	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
859657000544	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
859657000545	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
859657000546	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
859657000547	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
859657000548	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
859657000549	active site
859657000550	homodimer interface [polypeptide binding]; other site
859657000551	catalytic site [active]
859657000552	acceptor binding site [chemical binding]; other site
859657000553	glycogen synthase; Provisional; Region: glgA; PRK00654
859657000554	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
859657000555	ADP-binding pocket [chemical binding]; other site
859657000556	homodimer interface [polypeptide binding]; other site
859657000557	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547
859657000558	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
859657000559	Walker A/P-loop; other site
859657000560	ATP binding site [chemical binding]; other site
859657000561	Q-loop/lid; other site
859657000562	ABC transporter signature motif; other site
859657000563	Walker B; other site
859657000564	D-loop; other site
859657000565	H-loop/switch region; other site
859657000566	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
859657000567	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
859657000568	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
859657000569	ABC-ATPase subunit  interface; other site
859657000570	dimer interface [polypeptide binding]; other site
859657000571	putative PBP binding regions; other site
859657000572	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
859657000573	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
859657000574	intersubunit interface [polypeptide binding]; other site
859657000575	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
859657000576	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
859657000577	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
859657000578	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859657000579	N-terminal plug; other site
859657000580	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
859657000581	ligand-binding site [chemical binding]; other site
859657000582	peroxiredoxin; Region: AhpC; TIGR03137
859657000583	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
859657000584	dimer interface [polypeptide binding]; other site
859657000585	decamer (pentamer of dimers) interface [polypeptide binding]; other site
859657000586	catalytic triad [active]
859657000587	peroxidatic and resolving cysteines [active]
859657000588	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
859657000589	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
859657000590	catalytic residue [active]
859657000591	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
859657000592	catalytic residues [active]
859657000593	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859657000594	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859657000595	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
859657000596	metal binding site 2 [ion binding]; metal-binding site
859657000597	putative DNA binding helix; other site
859657000598	metal binding site 1 [ion binding]; metal-binding site
859657000599	dimer interface [polypeptide binding]; other site
859657000600	structural Zn2+ binding site [ion binding]; other site
859657000601	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
859657000602	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
859657000603	G1 box; other site
859657000604	GTP/Mg2+ binding site [chemical binding]; other site
859657000605	Switch I region; other site
859657000606	G2 box; other site
859657000607	G3 box; other site
859657000608	Switch II region; other site
859657000609	G4 box; other site
859657000610	G5 box; other site
859657000611	Nucleoside recognition; Region: Gate; pfam07670
859657000612	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
859657000613	Nucleoside recognition; Region: Gate; pfam07670
859657000614	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
859657000615	Cache domain; Region: Cache_1; pfam02743
859657000616	FOG: HAMP domain [Signal transduction mechanisms]; Region: ResE; COG2770
859657000617	PAS fold; Region: PAS; pfam00989
859657000618	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657000619	putative active site [active]
859657000620	heme pocket [chemical binding]; other site
859657000621	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657000622	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657000623	metal binding site [ion binding]; metal-binding site
859657000624	active site
859657000625	I-site; other site
859657000626	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657000627	dimerization interface [polypeptide binding]; other site
859657000628	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
859657000629	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657000630	putative active site [active]
859657000631	heme pocket [chemical binding]; other site
859657000632	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657000633	PAS domain; Region: PAS_9; pfam13426
859657000634	putative active site [active]
859657000635	heme pocket [chemical binding]; other site
859657000636	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657000637	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657000638	metal binding site [ion binding]; metal-binding site
859657000639	active site
859657000640	I-site; other site
859657000641	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657000642	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657000643	PAS fold; Region: PAS_3; pfam08447
859657000644	putative active site [active]
859657000645	heme pocket [chemical binding]; other site
859657000646	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
859657000647	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
859657000648	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657000649	dimer interface [polypeptide binding]; other site
859657000650	putative CheW interface [polypeptide binding]; other site
859657000651	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
859657000652	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
859657000653	FAD binding pocket [chemical binding]; other site
859657000654	FAD binding motif [chemical binding]; other site
859657000655	phosphate binding motif [ion binding]; other site
859657000656	NAD binding pocket [chemical binding]; other site
859657000657	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
859657000658	Predicted transcriptional regulators [Transcription]; Region: COG1695
859657000659	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
859657000660	putative substrate binding pocket [chemical binding]; other site
859657000661	AC domain interface; other site
859657000662	catalytic triad [active]
859657000663	AB domain interface; other site
859657000664	interchain disulfide; other site
859657000665	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859657000666	MarR family; Region: MarR_2; pfam12802
859657000667	Protein of unknown function (DUF3757); Region: DUF3757; pfam12582
859657000668	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
859657000669	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
859657000670	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657000671	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657000672	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657000673	dimerization interface [polypeptide binding]; other site
859657000674	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
859657000675	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
859657000676	metal binding site [ion binding]; metal-binding site
859657000677	putative dimer interface [polypeptide binding]; other site
859657000678	metabolite-proton symporter; Region: 2A0106; TIGR00883
859657000679	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657000680	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657000681	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
859657000682	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657000683	Coenzyme A binding pocket [chemical binding]; other site
859657000684	TIGR02679 family protein; Region: TIGR02679
859657000685	Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664
859657000686	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
859657000687	Transposase; Region: HTH_Tnp_1; cl17663
859657000688	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
859657000689	IS2 transposase TnpB; Reviewed; Region: PRK09409
859657000690	Integrase core domain; Region: rve; pfam00665
859657000691	Integrase core domain; Region: rve_3; pfam13683
859657000692	TIGR02680 family protein; Region: TIGR02680
859657000693	Protein of unknown function (DUF2398); Region: DUF2398; cl09875
859657000694	TIGR02677 family protein; Region: TIGR02677
859657000695	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
859657000696	DNA binding domain, excisionase family; Region: excise; TIGR01764
859657000697	PIN domain; Region: PIN_3; pfam13470
859657000698	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
859657000699	Part of AAA domain; Region: AAA_19; pfam13245
859657000700	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
859657000701	AAA domain; Region: AAA_12; pfam13087
859657000702	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
859657000703	putative active site [active]
859657000704	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
859657000705	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657000706	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
859657000707	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859657000708	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
859657000709	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
859657000710	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
859657000711	active site
859657000712	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
859657000713	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
859657000714	dimer interface [polypeptide binding]; other site
859657000715	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657000716	catalytic residue [active]
859657000717	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
859657000718	Trehalase; Region: Trehalase; cl17346
859657000719	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
859657000720	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
859657000721	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
859657000722	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
859657000723	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657000724	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
859657000725	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657000726	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657000727	metal binding site [ion binding]; metal-binding site
859657000728	active site
859657000729	I-site; other site
859657000730	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
859657000731	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657000732	binding surface
859657000733	TPR motif; other site
859657000734	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
859657000735	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657000736	binding surface
859657000737	TPR motif; other site
859657000738	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
859657000739	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
859657000740	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
859657000741	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657000742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
859657000743	active site
859657000744	phosphorylation site [posttranslational modification]
859657000745	dimerization interface [polypeptide binding]; other site
859657000746	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657000747	DNA binding residues [nucleotide binding]
859657000748	dimerization interface [polypeptide binding]; other site
859657000749	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
859657000750	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
859657000751	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
859657000752	putative active site [active]
859657000753	putative metal binding site [ion binding]; other site
859657000754	N-glycosyltransferase; Provisional; Region: PRK11204
859657000755	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
859657000756	DXD motif; other site
859657000757	PgaD-like protein; Region: PgaD; cl14676
859657000758	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
859657000759	Glycosyltransferase family 28 N-terminal domain; Region: Glyco_transf_28; pfam03033
859657000760	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
859657000761	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
859657000762	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
859657000763	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657000764	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657000765	A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases.  Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417
859657000766	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
859657000767	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
859657000768	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657000769	Walker A/P-loop; other site
859657000770	ATP binding site [chemical binding]; other site
859657000771	Q-loop/lid; other site
859657000772	ABC transporter signature motif; other site
859657000773	Walker B; other site
859657000774	D-loop; other site
859657000775	H-loop/switch region; other site
859657000776	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
859657000777	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
859657000778	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657000779	Coenzyme A binding pocket [chemical binding]; other site
859657000780	Tar ligand binding domain homologue; Region: TarH; pfam02203
859657000781	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657000782	dimerization interface [polypeptide binding]; other site
859657000783	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657000784	dimer interface [polypeptide binding]; other site
859657000785	putative CheW interface [polypeptide binding]; other site
859657000786	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
859657000787	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
859657000788	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657000789	NAD(P) binding site [chemical binding]; other site
859657000790	active site
859657000791	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
859657000792	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
859657000793	CGNR zinc finger; Region: zf-CGNR; pfam11706
859657000794	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
859657000795	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
859657000796	FMN binding site [chemical binding]; other site
859657000797	substrate binding site [chemical binding]; other site
859657000798	putative catalytic residue [active]
859657000799	LysR family transcriptional regulator; Provisional; Region: PRK14997
859657000800	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657000801	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657000802	putative effector binding pocket; other site
859657000803	dimerization interface [polypeptide binding]; other site
859657000804	Predicted transcriptional regulators [Transcription]; Region: COG1695
859657000805	Transcriptional regulator PadR-like family; Region: PadR; cl17335
859657000806	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
859657000807	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
859657000808	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
859657000809	FMN binding site [chemical binding]; other site
859657000810	substrate binding site [chemical binding]; other site
859657000811	putative catalytic residue [active]
859657000812	SnoaL-like domain; Region: SnoaL_2; pfam12680
859657000813	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859657000814	Ligand Binding Site [chemical binding]; other site
859657000815	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
859657000816	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
859657000817	Walker A/P-loop; other site
859657000818	ATP binding site [chemical binding]; other site
859657000819	ABC transporter signature motif; other site
859657000820	Walker B; other site
859657000821	D-loop; other site
859657000822	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859657000823	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
859657000824	Heavy-metal-associated domain; Region: HMA; pfam00403
859657000825	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
859657000826	Soluble P-type ATPase [General function prediction only]; Region: COG4087
859657000827	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
859657000828	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
859657000829	DNA binding residues [nucleotide binding]
859657000830	dimer interface [polypeptide binding]; other site
859657000831	putative metal binding site [ion binding]; other site
859657000832	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
859657000833	dimerization interface [polypeptide binding]; other site
859657000834	2-isopropylmalate synthase; Validated; Region: PRK03739
859657000835	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
859657000836	active site
859657000837	catalytic residues [active]
859657000838	metal binding site [ion binding]; metal-binding site
859657000839	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
859657000840	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
859657000841	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657000842	catalytic loop [active]
859657000843	iron binding site [ion binding]; other site
859657000844	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
859657000845	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
859657000846	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859657000847	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859657000848	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
859657000849	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
859657000850	Ligand binding site; other site
859657000851	metal-binding site
859657000852	PAS fold; Region: PAS_4; pfam08448
859657000853	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657000854	putative active site [active]
859657000855	heme pocket [chemical binding]; other site
859657000856	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657000857	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657000858	metal binding site [ion binding]; metal-binding site
859657000859	active site
859657000860	I-site; other site
859657000861	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657000862	H-NS histone family; Region: Histone_HNS; pfam00816
859657000863	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
859657000864	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
859657000865	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657000866	DNA-binding site [nucleotide binding]; DNA binding site
859657000867	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
859657000868	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657000869	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657000870	trimer interface [polypeptide binding]; other site
859657000871	eyelet of channel; other site
859657000872	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657000873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657000874	active site
859657000875	phosphorylation site [posttranslational modification]
859657000876	intermolecular recognition site; other site
859657000877	dimerization interface [polypeptide binding]; other site
859657000878	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657000879	DNA binding residues [nucleotide binding]
859657000880	dimerization interface [polypeptide binding]; other site
859657000881	FlgN protein; Region: FlgN; pfam05130
859657000882	Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747
859657000883	SAF-like; Region: SAF_2; pfam13144
859657000884	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
859657000885	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
859657000886	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
859657000887	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
859657000888	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
859657000889	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
859657000890	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
859657000891	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
859657000892	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
859657000893	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
859657000894	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
859657000895	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
859657000896	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
859657000897	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
859657000898	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
859657000899	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
859657000900	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
859657000901	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
859657000902	Flagellar L-ring protein; Region: FlgH; pfam02107
859657000903	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
859657000904	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
859657000905	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
859657000906	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
859657000907	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
859657000908	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
859657000909	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
859657000910	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
859657000911	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
859657000912	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
859657000913	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
859657000914	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
859657000915	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
859657000916	Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190
859657000917	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
859657000918	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
859657000919	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
859657000920	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
859657000921	PAS fold; Region: PAS_4; pfam08448
859657000922	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657000923	putative active site [active]
859657000924	heme pocket [chemical binding]; other site
859657000925	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657000926	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657000927	metal binding site [ion binding]; metal-binding site
859657000928	active site
859657000929	I-site; other site
859657000930	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657000931	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657000932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657000933	active site
859657000934	phosphorylation site [posttranslational modification]
859657000935	intermolecular recognition site; other site
859657000936	dimerization interface [polypeptide binding]; other site
859657000937	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657000938	DNA binding residues [nucleotide binding]
859657000939	dimerization interface [polypeptide binding]; other site
859657000940	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
859657000941	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
859657000942	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
859657000943	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
859657000944	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
859657000945	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
859657000946	Flagellar protein FliT; Region: FliT; pfam05400
859657000947	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859657000948	MarR family; Region: MarR; pfam01047
859657000949	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
859657000950	putative metal binding site; other site
859657000951	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
859657000952	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
859657000953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
859657000954	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
859657000955	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
859657000956	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
859657000957	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
859657000958	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
859657000959	FliG C-terminal domain; Region: FliG_C; pfam01706
859657000960	flagellar assembly protein H; Validated; Region: fliH; PRK05687
859657000961	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
859657000962	Flagellar assembly protein FliH; Region: FliH; pfam02108
859657000963	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
859657000964	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
859657000965	Walker A motif/ATP binding site; other site
859657000966	Walker B motif; other site
859657000967	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
859657000968	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
859657000969	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
859657000970	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
859657000971	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
859657000972	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
859657000973	active site residue [active]
859657000974	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
859657000975	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657000976	Coenzyme A binding pocket [chemical binding]; other site
859657000977	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
859657000978	Cache domain; Region: Cache_1; pfam02743
859657000979	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657000980	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657000981	metal binding site [ion binding]; metal-binding site
859657000982	active site
859657000983	I-site; other site
859657000984	TPR repeat; Region: TPR_11; pfam13414
859657000985	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657000986	TPR motif; other site
859657000987	binding surface
859657000988	Cache domain; Region: Cache_1; pfam02743
859657000989	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657000990	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657000991	metal binding site [ion binding]; metal-binding site
859657000992	active site
859657000993	I-site; other site
859657000994	BON domain; Region: BON; pfam04972
859657000995	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
859657000996	Predicted membrane protein [Function unknown]; Region: COG4291
859657000997	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
859657000998	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657000999	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859657001000	putative substrate translocation pore; other site
859657001001	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
859657001002	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859657001003	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859657001004	N-terminal plug; other site
859657001005	ligand-binding site [chemical binding]; other site
859657001006	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
859657001007	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657001008	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657001009	DNA binding residues [nucleotide binding]
859657001010	Secretin and TonB N terminus short domain; Region: STN; smart00965
859657001011	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859657001012	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859657001013	N-terminal plug; other site
859657001014	ligand-binding site [chemical binding]; other site
859657001015	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
859657001016	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
859657001017	dimer interface [polypeptide binding]; other site
859657001018	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657001019	catalytic residue [active]
859657001020	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
859657001021	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
859657001022	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
859657001023	IucA / IucC family; Region: IucA_IucC; pfam04183
859657001024	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
859657001025	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859657001026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
859657001027	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
859657001028	IucA / IucC family; Region: IucA_IucC; pfam04183
859657001029	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
859657001030	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
859657001031	IucA / IucC family; Region: IucA_IucC; pfam04183
859657001032	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
859657001033	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
859657001034	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
859657001035	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
859657001036	dimer interface [polypeptide binding]; other site
859657001037	active site
859657001038	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859657001039	catalytic residues [active]
859657001040	substrate binding site [chemical binding]; other site
859657001041	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657001042	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657001043	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657001044	putative effector binding pocket; other site
859657001045	dimerization interface [polypeptide binding]; other site
859657001046	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
859657001047	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
859657001048	putative NAD(P) binding site [chemical binding]; other site
859657001049	catalytic Zn binding site [ion binding]; other site
859657001050	putative substrate binding site [chemical binding]; other site
859657001051	structural Zn binding site [ion binding]; other site
859657001052	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
859657001053	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859657001054	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657001055	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657001056	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657001057	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859657001058	short chain dehydrogenase; Provisional; Region: PRK06940
859657001059	classical (c) SDRs; Region: SDR_c; cd05233
859657001060	NAD(P) binding site [chemical binding]; other site
859657001061	active site
859657001062	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926
859657001063	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
859657001064	LysE type translocator; Region: LysE; cl00565
859657001065	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
859657001066	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657001067	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657001068	dimerization interface [polypeptide binding]; other site
859657001069	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
859657001070	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
859657001071	acyl-activating enzyme (AAE) consensus motif; other site
859657001072	AMP binding site [chemical binding]; other site
859657001073	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657001074	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
859657001075	NADPH bind site [chemical binding]; other site
859657001076	putative FMN binding site [chemical binding]; other site
859657001077	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
859657001078	putative FMN binding site [chemical binding]; other site
859657001079	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859657001080	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001081	active site
859657001082	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859657001083	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001084	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
859657001085	active site
859657001086	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859657001087	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859657001088	putative NADP binding site [chemical binding]; other site
859657001089	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859657001090	active site
859657001091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657001092	S-adenosylmethionine binding site [chemical binding]; other site
859657001093	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657001094	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001095	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
859657001096	active site
859657001097	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859657001098	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859657001099	KR domain; Region: KR; pfam08659
859657001100	putative NADP binding site [chemical binding]; other site
859657001101	active site
859657001102	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859657001103	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859657001104	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001105	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859657001106	active site
859657001107	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859657001108	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859657001109	putative NADP binding site [chemical binding]; other site
859657001110	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859657001111	active site
859657001112	Methyltransferase domain; Region: Methyltransf_12; pfam08242
859657001113	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657001114	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001115	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859657001116	active site
859657001117	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859657001118	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859657001119	putative NADP binding site [chemical binding]; other site
859657001120	active site
859657001121	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657001122	S-adenosylmethionine binding site [chemical binding]; other site
859657001123	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859657001124	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001125	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859657001126	active site
859657001127	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859657001128	KR domain; Region: KR; pfam08659
859657001129	putative NADP binding site [chemical binding]; other site
859657001130	active site
859657001131	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657001132	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001133	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859657001134	active site
859657001135	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657001136	NAD(P) binding site [chemical binding]; other site
859657001137	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859657001138	active site
859657001139	Methyltransferase domain; Region: Methyltransf_31; pfam13847
859657001140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657001141	S-adenosylmethionine binding site [chemical binding]; other site
859657001142	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859657001143	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859657001144	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657001145	S-adenosylmethionine binding site [chemical binding]; other site
859657001146	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001147	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
859657001148	active site
859657001149	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859657001150	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859657001151	KR domain; Region: KR; pfam08659
859657001152	putative NADP binding site [chemical binding]; other site
859657001153	active site
859657001154	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657001155	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001156	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
859657001157	active site
859657001158	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859657001159	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859657001160	putative NADP binding site [chemical binding]; other site
859657001161	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859657001162	active site
859657001163	Methyltransferase domain; Region: Methyltransf_12; pfam08242
859657001164	Methyltransferase domain; Region: Methyltransf_23; pfam13489
859657001165	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859657001166	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001167	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859657001168	active site
859657001169	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
859657001170	Cytochrome P450; Region: p450; cl12078
859657001171	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859657001172	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859657001173	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001174	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
859657001175	active site
859657001176	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859657001177	putative NADP binding site [chemical binding]; other site
859657001178	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859657001179	active site
859657001180	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657001181	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859657001182	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001183	active site
859657001184	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859657001185	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859657001186	putative NADP binding site [chemical binding]; other site
859657001187	KR domain; Region: KR; pfam08659
859657001188	active site
859657001189	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859657001190	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859657001191	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001192	active site
859657001193	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657001194	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859657001195	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001196	active site
859657001197	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859657001198	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859657001199	putative NADP binding site [chemical binding]; other site
859657001200	KR domain; Region: KR; pfam08659
859657001201	active site
859657001202	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657001203	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001204	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859657001205	active site
859657001206	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657001207	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
859657001208	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657001209	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859657001210	active site
859657001211	Condensation domain; Region: Condensation; pfam00668
859657001212	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859657001213	Nonribosomal peptide synthase; Region: NRPS; pfam08415
859657001214	Condensation domain; Region: Condensation; pfam00668
859657001215	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859657001216	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
859657001217	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
859657001218	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
859657001219	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
859657001220	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
859657001221	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859657001222	Walker A/P-loop; other site
859657001223	ATP binding site [chemical binding]; other site
859657001224	Q-loop/lid; other site
859657001225	ABC transporter signature motif; other site
859657001226	Walker B; other site
859657001227	D-loop; other site
859657001228	H-loop/switch region; other site
859657001229	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859657001230	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657001231	dimer interface [polypeptide binding]; other site
859657001232	conserved gate region; other site
859657001233	putative PBP binding loops; other site
859657001234	ABC-ATPase subunit interface; other site
859657001235	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657001236	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859657001237	substrate binding pocket [chemical binding]; other site
859657001238	membrane-bound complex binding site; other site
859657001239	hinge residues; other site
859657001240	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859657001241	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
859657001242	AsnC family; Region: AsnC_trans_reg; pfam01037
859657001243	ornithine cyclodeaminase; Validated; Region: PRK07589
859657001244	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
859657001245	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
859657001246	Amidinotransferase; Region: Amidinotransf; pfam02274
859657001247	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
859657001248	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859657001249	motif II; other site
859657001250	Protein of unknown function (DUF3005); Region: DUF3005; pfam11448
859657001251	hypothetical protein; Provisional; Region: PRK08262
859657001252	M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674
859657001253	metal binding site [ion binding]; metal-binding site
859657001254	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
859657001255	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657001256	dimer interface [polypeptide binding]; other site
859657001257	phosphorylation site [posttranslational modification]
859657001258	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657001259	ATP binding site [chemical binding]; other site
859657001260	Mg2+ binding site [ion binding]; other site
859657001261	G-X-G motif; other site
859657001262	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
859657001263	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657001264	active site
859657001265	phosphorylation site [posttranslational modification]
859657001266	intermolecular recognition site; other site
859657001267	dimerization interface [polypeptide binding]; other site
859657001268	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657001269	DNA binding site [nucleotide binding]
859657001270	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
859657001271	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657001272	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
859657001273	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657001274	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
859657001275	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
859657001276	nucleotide binding site/active site [active]
859657001277	HIT family signature motif; other site
859657001278	catalytic residue [active]
859657001279	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657001280	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657001281	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
859657001282	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
859657001283	putative ligand binding site [chemical binding]; other site
859657001284	NAD binding site [chemical binding]; other site
859657001285	catalytic site [active]
859657001286	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859657001287	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
859657001288	dimer interface [polypeptide binding]; other site
859657001289	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657001290	dimerization interface [polypeptide binding]; other site
859657001291	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657001292	dimer interface [polypeptide binding]; other site
859657001293	putative CheW interface [polypeptide binding]; other site
859657001294	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
859657001295	active site
859657001296	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
859657001297	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
859657001298	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
859657001299	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
859657001300	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
859657001301	active site
859657001302	homodimer interface [polypeptide binding]; other site
859657001303	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
859657001304	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
859657001305	NodB motif; other site
859657001306	putative active site [active]
859657001307	putative catalytic site [active]
859657001308	putative Zn binding site [ion binding]; other site
859657001309	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
859657001310	Mechanosensitive ion channel; Region: MS_channel; pfam00924
859657001311	Uncharacterized conserved protein [Function unknown]; Region: COG4104
859657001312	PGAP1-like protein; Region: PGAP1; pfam07819
859657001313	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859657001314	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859657001315	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859657001316	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859657001317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859657001318	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657001319	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657001320	metal binding site [ion binding]; metal-binding site
859657001321	active site
859657001322	I-site; other site
859657001323	manganese transport protein MntH; Reviewed; Region: PRK00701
859657001324	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
859657001325	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
859657001326	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
859657001327	nucleotide binding site [chemical binding]; other site
859657001328	putative NEF/HSP70 interaction site [polypeptide binding]; other site
859657001329	SBD interface [polypeptide binding]; other site
859657001330	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
859657001331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657001332	active site
859657001333	phosphorylation site [posttranslational modification]
859657001334	intermolecular recognition site; other site
859657001335	dimerization interface [polypeptide binding]; other site
859657001336	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657001337	DNA binding site [nucleotide binding]
859657001338	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657001339	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
859657001340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657001341	dimer interface [polypeptide binding]; other site
859657001342	phosphorylation site [posttranslational modification]
859657001343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657001344	ATP binding site [chemical binding]; other site
859657001345	Mg2+ binding site [ion binding]; other site
859657001346	G-X-G motif; other site
859657001347	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
859657001348	NADH(P)-binding; Region: NAD_binding_10; pfam13460
859657001349	NAD binding site [chemical binding]; other site
859657001350	putative active site [active]
859657001351	substrate binding site [chemical binding]; other site
859657001352	Predicted transcriptional regulator [Transcription]; Region: COG1959
859657001353	Transcriptional regulator; Region: Rrf2; pfam02082
859657001354	Transcriptional regulator; Region: Rrf2; cl17282
859657001355	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
859657001356	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657001357	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657001358	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657001359	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
859657001360	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
859657001361	Nitrogen regulatory protein P-II; Region: P-II; smart00938
859657001362	Peptidase family M1; Region: Peptidase_M1; pfam01433
859657001363	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
859657001364	Zn binding site [ion binding]; other site
859657001365	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
859657001366	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
859657001367	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657001368	haemagglutination activity domain; Region: Haemagg_act; pfam05860
859657001369	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859657001370	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859657001371	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859657001372	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
859657001373	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
859657001374	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
859657001375	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
859657001376	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
859657001377	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859657001378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657001379	active site
859657001380	phosphorylation site [posttranslational modification]
859657001381	intermolecular recognition site; other site
859657001382	dimerization interface [polypeptide binding]; other site
859657001383	WHG domain; Region: WHG; pfam13305
859657001384	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
859657001385	SnoaL-like domain; Region: SnoaL_3; pfam13474
859657001386	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
859657001387	dimer interface [polypeptide binding]; other site
859657001388	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859657001389	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
859657001390	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
859657001391	putative active site [active]
859657001392	putative catalytic triad [active]
859657001393	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
859657001394	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
859657001395	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
859657001396	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
859657001397	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
859657001398	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
859657001399	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
859657001400	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
859657001401	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
859657001402	FAD binding pocket [chemical binding]; other site
859657001403	FAD binding motif [chemical binding]; other site
859657001404	phosphate binding motif [ion binding]; other site
859657001405	beta-alpha-beta structure motif; other site
859657001406	NAD(p) ribose binding residues [chemical binding]; other site
859657001407	NAD binding pocket [chemical binding]; other site
859657001408	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
859657001409	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657001410	catalytic loop [active]
859657001411	iron binding site [ion binding]; other site
859657001412	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
859657001413	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
859657001414	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657001415	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657001416	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
859657001417	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
859657001418	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
859657001419	active site residue [active]
859657001420	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
859657001421	active site residue [active]
859657001422	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
859657001423	active site residue [active]
859657001424	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
859657001425	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859657001426	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859657001427	catalytic residue [active]
859657001428	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
859657001429	putative FMN binding site [chemical binding]; other site
859657001430	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
859657001431	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
859657001432	catalytic triad [active]
859657001433	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
859657001434	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
859657001435	Walker A motif; other site
859657001436	homodimer interface [polypeptide binding]; other site
859657001437	ATP binding site [chemical binding]; other site
859657001438	hydroxycobalamin binding site [chemical binding]; other site
859657001439	Walker B motif; other site
859657001440	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
859657001441	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
859657001442	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
859657001443	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
859657001444	active site
859657001445	SAM binding site [chemical binding]; other site
859657001446	homodimer interface [polypeptide binding]; other site
859657001447	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
859657001448	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
859657001449	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
859657001450	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
859657001451	cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027
859657001452	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
859657001453	active site
859657001454	SAM binding site [chemical binding]; other site
859657001455	homodimer interface [polypeptide binding]; other site
859657001456	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
859657001457	active site
859657001458	SAM binding site [chemical binding]; other site
859657001459	homodimer interface [polypeptide binding]; other site
859657001460	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
859657001461	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
859657001462	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
859657001463	putative active site [active]
859657001464	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
859657001465	putative active site [active]
859657001466	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
859657001467	Precorrin-8X methylmutase; Region: CbiC; pfam02570
859657001468	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
859657001469	active site
859657001470	putative homodimer interface [polypeptide binding]; other site
859657001471	SAM binding site [chemical binding]; other site
859657001472	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
859657001473	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
859657001474	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
859657001475	metal ion-dependent adhesion site (MIDAS); other site
859657001476	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
859657001477	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
859657001478	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
859657001479	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
859657001480	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
859657001481	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
859657001482	dimer interface [polypeptide binding]; other site
859657001483	[2Fe-2S] cluster binding site [ion binding]; other site
859657001484	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
859657001485	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
859657001486	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859657001487	Walker A/P-loop; other site
859657001488	ATP binding site [chemical binding]; other site
859657001489	Q-loop/lid; other site
859657001490	ABC transporter signature motif; other site
859657001491	Walker B; other site
859657001492	D-loop; other site
859657001493	H-loop/switch region; other site
859657001494	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859657001495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657001496	dimer interface [polypeptide binding]; other site
859657001497	conserved gate region; other site
859657001498	putative PBP binding loops; other site
859657001499	ABC-ATPase subunit interface; other site
859657001500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657001501	dimer interface [polypeptide binding]; other site
859657001502	conserved gate region; other site
859657001503	putative PBP binding loops; other site
859657001504	ABC-ATPase subunit interface; other site
859657001505	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657001506	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859657001507	substrate binding pocket [chemical binding]; other site
859657001508	membrane-bound complex binding site; other site
859657001509	hinge residues; other site
859657001510	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
859657001511	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
859657001512	putative active site [active]
859657001513	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
859657001514	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
859657001515	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657001516	dimerization interface [polypeptide binding]; other site
859657001517	putative DNA binding site [nucleotide binding]; other site
859657001518	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859657001519	putative Zn2+ binding site [ion binding]; other site
859657001520	AsnC family; Region: AsnC_trans_reg; pfam01037
859657001521	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
859657001522	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
859657001523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657001524	catalytic residue [active]
859657001525	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
859657001526	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657001527	substrate binding site [chemical binding]; other site
859657001528	oxyanion hole (OAH) forming residues; other site
859657001529	trimer interface [polypeptide binding]; other site
859657001530	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
859657001531	enoyl-CoA hydratase; Provisional; Region: PRK09076
859657001532	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657001533	substrate binding site [chemical binding]; other site
859657001534	oxyanion hole (OAH) forming residues; other site
859657001535	trimer interface [polypeptide binding]; other site
859657001536	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
859657001537	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
859657001538	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
859657001539	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
859657001540	tetrameric interface [polypeptide binding]; other site
859657001541	NAD binding site [chemical binding]; other site
859657001542	catalytic residues [active]
859657001543	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
859657001544	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
859657001545	active site
859657001546	acyl-activating enzyme (AAE) consensus motif; other site
859657001547	putative CoA binding site [chemical binding]; other site
859657001548	AMP binding site [chemical binding]; other site
859657001549	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859657001550	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859657001551	active site
859657001552	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
859657001553	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859657001554	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657001555	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
859657001556	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657001557	dimerization interface [polypeptide binding]; other site
859657001558	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657001559	dimer interface [polypeptide binding]; other site
859657001560	phosphorylation site [posttranslational modification]
859657001561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657001562	ATP binding site [chemical binding]; other site
859657001563	Mg2+ binding site [ion binding]; other site
859657001564	G-X-G motif; other site
859657001565	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
859657001566	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657001567	active site
859657001568	phosphorylation site [posttranslational modification]
859657001569	intermolecular recognition site; other site
859657001570	dimerization interface [polypeptide binding]; other site
859657001571	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657001572	DNA binding site [nucleotide binding]
859657001573	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
859657001574	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
859657001575	Multicopper oxidase; Region: Cu-oxidase; pfam00394
859657001576	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
859657001577	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: PcoB; COG3667
859657001578	CopC domain; Region: CopC; pfam04234
859657001579	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
859657001580	Uncharacterized conserved protein [Function unknown]; Region: COG5649
859657001581	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859657001582	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657001583	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657001584	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859657001585	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657001586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657001587	active site
859657001588	phosphorylation site [posttranslational modification]
859657001589	intermolecular recognition site; other site
859657001590	dimerization interface [polypeptide binding]; other site
859657001591	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657001592	DNA binding site [nucleotide binding]
859657001593	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657001594	HAMP domain; Region: HAMP; pfam00672
859657001595	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657001596	dimer interface [polypeptide binding]; other site
859657001597	phosphorylation site [posttranslational modification]
859657001598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657001599	ATP binding site [chemical binding]; other site
859657001600	Mg2+ binding site [ion binding]; other site
859657001601	G-X-G motif; other site
859657001602	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657001603	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657001604	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657001605	dimerization interface [polypeptide binding]; other site
859657001606	Predicted membrane protein [Function unknown]; Region: COG2259
859657001607	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
859657001608	putative FMN binding site [chemical binding]; other site
859657001609	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
859657001610	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859657001611	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657001612	NADH(P)-binding; Region: NAD_binding_10; pfam13460
859657001613	Pirin-related protein [General function prediction only]; Region: COG1741
859657001614	Pirin; Region: Pirin; pfam02678
859657001615	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859657001616	Predicted flavoprotein [General function prediction only]; Region: COG0431
859657001617	SnoaL-like domain; Region: SnoaL_2; pfam12680
859657001618	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
859657001619	ligand binding site [chemical binding]; other site
859657001620	flexible hinge region; other site
859657001621	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
859657001622	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859657001623	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859657001624	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
859657001625	Isochorismatase family; Region: Isochorismatase; pfam00857
859657001626	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
859657001627	catalytic triad [active]
859657001628	dimer interface [polypeptide binding]; other site
859657001629	conserved cis-peptide bond; other site
859657001630	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657001631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657001632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657001633	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859657001634	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657001635	putative DNA binding site [nucleotide binding]; other site
859657001636	putative Zn2+ binding site [ion binding]; other site
859657001637	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
859657001638	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
859657001639	oligomer interface [polypeptide binding]; other site
859657001640	metal binding site [ion binding]; metal-binding site
859657001641	metal binding site [ion binding]; metal-binding site
859657001642	putative Cl binding site [ion binding]; other site
859657001643	basic sphincter; other site
859657001644	hydrophobic gate; other site
859657001645	periplasmic entrance; other site
859657001646	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
859657001647	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
859657001648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657001649	Uncharacterized conserved protein [Function unknown]; Region: COG5495
859657001650	Rossmann-like domain; Region: Rossmann-like; pfam10727
859657001651	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
859657001652	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
859657001653	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859657001654	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657001655	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657001656	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
859657001657	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657001658	substrate binding site [chemical binding]; other site
859657001659	oxyanion hole (OAH) forming residues; other site
859657001660	trimer interface [polypeptide binding]; other site
859657001661	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657001662	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859657001663	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657001664	Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462
859657001665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
859657001666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380
859657001667	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
859657001668	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
859657001669	THF binding site; other site
859657001670	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
859657001671	substrate binding site [chemical binding]; other site
859657001672	THF binding site; other site
859657001673	zinc-binding site [ion binding]; other site
859657001674	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
859657001675	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657001676	putative DNA binding site [nucleotide binding]; other site
859657001677	putative Zn2+ binding site [ion binding]; other site
859657001678	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
859657001679	putative dimerization interface [polypeptide binding]; other site
859657001680	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
859657001681	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
859657001682	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
859657001683	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
859657001684	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
859657001685	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859657001686	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
859657001687	active site
859657001688	ribulose/triose binding site [chemical binding]; other site
859657001689	phosphate binding site [ion binding]; other site
859657001690	substrate (anthranilate) binding pocket [chemical binding]; other site
859657001691	product (indole) binding pocket [chemical binding]; other site
859657001692	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
859657001693	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
859657001694	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
859657001695	Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain.  TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929
859657001696	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
859657001697	FMN binding site [chemical binding]; other site
859657001698	active site
859657001699	homodimer interface [polypeptide binding]; other site
859657001700	putative catalytic residue [active]
859657001701	4Fe-4S cluster binding site [ion binding]; other site
859657001702	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
859657001703	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
859657001704	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859657001705	catalytic residue [active]
859657001706	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
859657001707	B3/4 domain; Region: B3_4; pfam03483
859657001708	EamA-like transporter family; Region: EamA; pfam00892
859657001709	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
859657001710	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
859657001711	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859657001712	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859657001713	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859657001714	active site
859657001715	Predicted small integral membrane protein [Function unknown]; Region: COG5472
859657001716	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
859657001717	fumarylacetoacetase; Region: PLN02856
859657001718	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
859657001719	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
859657001720	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
859657001721	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657001722	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657001723	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
859657001724	substrate binding pocket [chemical binding]; other site
859657001725	dimerization interface [polypeptide binding]; other site
859657001726	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
859657001727	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
859657001728	hypothetical protein; Reviewed; Region: PRK09588
859657001729	release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073
859657001730	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
859657001731	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
859657001732	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859657001733	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859657001734	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
859657001735	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859657001736	Transcriptional regulator [Transcription]; Region: IclR; COG1414
859657001737	Bacterial transcriptional regulator; Region: IclR; pfam01614
859657001738	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859657001739	TM-ABC transporter signature motif; other site
859657001740	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859657001741	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859657001742	TM-ABC transporter signature motif; other site
859657001743	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859657001744	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859657001745	Walker A/P-loop; other site
859657001746	ATP binding site [chemical binding]; other site
859657001747	Q-loop/lid; other site
859657001748	ABC transporter signature motif; other site
859657001749	Walker B; other site
859657001750	D-loop; other site
859657001751	H-loop/switch region; other site
859657001752	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859657001753	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859657001754	Walker A/P-loop; other site
859657001755	ATP binding site [chemical binding]; other site
859657001756	Q-loop/lid; other site
859657001757	ABC transporter signature motif; other site
859657001758	Walker B; other site
859657001759	D-loop; other site
859657001760	H-loop/switch region; other site
859657001761	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
859657001762	Cytochrome P450; Region: p450; cl12078
859657001763	EamA-like transporter family; Region: EamA; pfam00892
859657001764	Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486
859657001765	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
859657001766	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
859657001767	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
859657001768	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657001769	Coenzyme A binding pocket [chemical binding]; other site
859657001770	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
859657001771	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
859657001772	homodimer interface [polypeptide binding]; other site
859657001773	substrate-cofactor binding pocket; other site
859657001774	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657001775	catalytic residue [active]
859657001776	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
859657001777	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
859657001778	FMN-binding domain; Region: FMN_bind; pfam04205
859657001779	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
859657001780	active site flap/lid [active]
859657001781	nucleophilic elbow; other site
859657001782	catalytic triad [active]
859657001783	L-aspartate dehydrogenase; Provisional; Region: PRK13303
859657001784	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
859657001785	Domain of unknown function DUF108; Region: DUF108; pfam01958
859657001786	Uncharacterized conserved protein [Function unknown]; Region: COG3542
859657001787	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
859657001788	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
859657001789	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
859657001790	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
859657001791	active site
859657001792	homotetramer interface [polypeptide binding]; other site
859657001793	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657001794	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657001795	trimer interface [polypeptide binding]; other site
859657001796	eyelet of channel; other site
859657001797	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
859657001798	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
859657001799	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
859657001800	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
859657001801	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
859657001802	ligand binding site [chemical binding]; other site
859657001803	homodimer interface [polypeptide binding]; other site
859657001804	NAD(P) binding site [chemical binding]; other site
859657001805	trimer interface B [polypeptide binding]; other site
859657001806	trimer interface A [polypeptide binding]; other site
859657001807	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
859657001808	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
859657001809	putative NAD(P) binding site [chemical binding]; other site
859657001810	catalytic Zn binding site [ion binding]; other site
859657001811	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
859657001812	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
859657001813	NADP binding site [chemical binding]; other site
859657001814	homodimer interface [polypeptide binding]; other site
859657001815	active site
859657001816	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
859657001817	ATP-binding site [chemical binding]; other site
859657001818	Gluconate-6-phosphate binding site [chemical binding]; other site
859657001819	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
859657001820	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
859657001821	dimerization interface [polypeptide binding]; other site
859657001822	ligand binding site [chemical binding]; other site
859657001823	NADP binding site [chemical binding]; other site
859657001824	catalytic site [active]
859657001825	hypothetical protein; Validated; Region: PRK06201
859657001826	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
859657001827	aspartate aminotransferase; Provisional; Region: PRK06107
859657001828	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657001829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657001830	homodimer interface [polypeptide binding]; other site
859657001831	catalytic residue [active]
859657001832	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
859657001833	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657001834	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
859657001835	putative dimerization interface [polypeptide binding]; other site
859657001836	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
859657001837	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
859657001838	carboxyltransferase (CT) interaction site; other site
859657001839	biotinylation site [posttranslational modification]; other site
859657001840	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
859657001841	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
859657001842	ATP-grasp domain; Region: ATP-grasp_4; cl17255
859657001843	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
859657001844	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
859657001845	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
859657001846	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
859657001847	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
859657001848	lipoyl-biotinyl attachment site [posttranslational modification]; other site
859657001849	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
859657001850	putative active site [active]
859657001851	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
859657001852	classical (c) SDRs; Region: SDR_c; cd05233
859657001853	NAD(P) binding site [chemical binding]; other site
859657001854	active site
859657001855	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859657001856	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657001857	dimer interface [polypeptide binding]; other site
859657001858	conserved gate region; other site
859657001859	putative PBP binding loops; other site
859657001860	ABC-ATPase subunit interface; other site
859657001861	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657001862	dimer interface [polypeptide binding]; other site
859657001863	conserved gate region; other site
859657001864	putative PBP binding loops; other site
859657001865	ABC-ATPase subunit interface; other site
859657001866	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
859657001867	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859657001868	Walker A/P-loop; other site
859657001869	ATP binding site [chemical binding]; other site
859657001870	Q-loop/lid; other site
859657001871	ABC transporter signature motif; other site
859657001872	Walker B; other site
859657001873	D-loop; other site
859657001874	H-loop/switch region; other site
859657001875	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859657001876	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657001877	substrate binding pocket [chemical binding]; other site
859657001878	membrane-bound complex binding site; other site
859657001879	hinge residues; other site
859657001880	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859657001881	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859657001882	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859657001883	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859657001884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859657001885	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
859657001886	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
859657001887	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
859657001888	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
859657001889	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657001890	TPR motif; other site
859657001891	binding surface
859657001892	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
859657001893	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
859657001894	Protein of unknown function (DUF877); Region: DUF877; pfam05943
859657001895	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
859657001896	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
859657001897	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
859657001898	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
859657001899	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
859657001900	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
859657001901	Clp amino terminal domain; Region: Clp_N; pfam02861
859657001902	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657001903	Walker A motif; other site
859657001904	ATP binding site [chemical binding]; other site
859657001905	Walker B motif; other site
859657001906	arginine finger; other site
859657001907	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657001908	Walker A motif; other site
859657001909	ATP binding site [chemical binding]; other site
859657001910	Walker B motif; other site
859657001911	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
859657001912	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
859657001913	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859657001914	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859657001915	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859657001916	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859657001917	Evidence 4 : Homologs of previously reported genes of unknown function
859657001918	Evidence 4 : Homologs of previously reported genes of unknown function
859657001919	Transposase; Region: HTH_Tnp_Tc3_2; pfam01498
859657001920	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859657001921	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
859657001922	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859657001923	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859657001924	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657001925	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859657001926	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859657001927	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859657001928	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
859657001929	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
859657001930	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
859657001931	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
859657001932	Protein of unknown function, DUF393; Region: DUF393; cl01136
859657001933	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
859657001934	Beta-lactamase; Region: Beta-lactamase; pfam00144
859657001935	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
859657001936	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
859657001937	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
859657001938	ligand binding site [chemical binding]; other site
859657001939	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SciT; COG3913
859657001940	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
859657001941	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
859657001942	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
859657001943	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
859657001944	PAAR motif; Region: PAAR_motif; pfam05488
859657001945	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
859657001946	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
859657001947	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11136451, 9696756
859657001948	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11136451, 9696756
859657001949	Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104
859657001950	putative active site [active]
859657001951	catalytic site [active]
859657001952	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859657001953	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859657001954	Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins; Region: PLDc_vPLD1_2_yPLD_like_2; cd09141
859657001955	putative active site [active]
859657001956	catalytic site [active]
859657001957	MEKHLA domain; Region: MEKHLA; pfam08670
859657001958	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
859657001959	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657001960	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657001961	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657001962	dimerization interface [polypeptide binding]; other site
859657001963	SnoaL-like domain; Region: SnoaL_2; pfam12680
859657001964	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
859657001965	Autoinducer binding domain; Region: Autoind_bind; pfam03472
859657001966	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657001967	DNA binding residues [nucleotide binding]
859657001968	dimerization interface [polypeptide binding]; other site
859657001969	Autoinducer synthetase; Region: Autoind_synth; cl17404
859657001970	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
859657001971	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
859657001972	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859657001973	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859657001974	catalytic residue [active]
859657001975	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859657001976	tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133
859657001977	active site
859657001978	HIGH motif; other site
859657001979	nucleotide binding site [chemical binding]; other site
859657001980	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859657001981	active site
859657001982	KMSKS motif; other site
859657001983	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
859657001984	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
859657001985	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
859657001986	putative di-iron ligands [ion binding]; other site
859657001987	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
859657001988	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
859657001989	active site
859657001990	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
859657001991	acyl-CoA synthetase; Validated; Region: PRK09192
859657001992	acyl-activating enzyme (AAE) consensus motif; other site
859657001993	active site
859657001994	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
859657001995	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
859657001996	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859657001997	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859657001998	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
859657001999	Fatty acid desaturase; Region: FA_desaturase; pfam00487
859657002000	Di-iron ligands [ion binding]; other site
859657002001	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
859657002002	aspartate aminotransferase; Provisional; Region: PRK06108
859657002003	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657002004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657002005	homodimer interface [polypeptide binding]; other site
859657002006	catalytic residue [active]
859657002007	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657002008	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657002009	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
859657002010	dimerization interface [polypeptide binding]; other site
859657002011	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
859657002012	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
859657002013	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657002014	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657002015	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657002016	dimerization interface [polypeptide binding]; other site
859657002017	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
859657002018	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515
859657002019	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
859657002020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657002021	dimer interface [polypeptide binding]; other site
859657002022	conserved gate region; other site
859657002023	putative PBP binding loops; other site
859657002024	ABC-ATPase subunit interface; other site
859657002025	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
859657002026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657002027	dimer interface [polypeptide binding]; other site
859657002028	conserved gate region; other site
859657002029	putative PBP binding loops; other site
859657002030	ABC-ATPase subunit interface; other site
859657002031	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
859657002032	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859657002033	Walker A/P-loop; other site
859657002034	ATP binding site [chemical binding]; other site
859657002035	Q-loop/lid; other site
859657002036	ABC transporter signature motif; other site
859657002037	Walker B; other site
859657002038	D-loop; other site
859657002039	H-loop/switch region; other site
859657002040	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
859657002041	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859657002042	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
859657002043	Walker A/P-loop; other site
859657002044	ATP binding site [chemical binding]; other site
859657002045	Q-loop/lid; other site
859657002046	ABC transporter signature motif; other site
859657002047	Walker B; other site
859657002048	D-loop; other site
859657002049	H-loop/switch region; other site
859657002050	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
859657002051	hypothetical protein; Provisional; Region: PRK07079
859657002052	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
859657002053	metal binding site [ion binding]; metal-binding site
859657002054	putative dimer interface [polypeptide binding]; other site
859657002055	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
859657002056	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657002057	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657002058	benzoate transport; Region: 2A0115; TIGR00895
859657002059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657002060	putative substrate translocation pore; other site
859657002061	DNA Polymerase Y-family; Region: PolY_like; cd03468
859657002062	active site
859657002063	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
859657002064	DNA binding site [nucleotide binding]
859657002065	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
859657002066	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
859657002067	putative active site [active]
859657002068	putative PHP Thumb interface [polypeptide binding]; other site
859657002069	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
859657002070	generic binding surface II; other site
859657002071	generic binding surface I; other site
859657002072	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657002073	non-specific DNA binding site [nucleotide binding]; other site
859657002074	salt bridge; other site
859657002075	sequence-specific DNA binding site [nucleotide binding]; other site
859657002076	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
859657002077	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
859657002078	transmembrane helices; other site
859657002079	elongation factor G; Reviewed; Region: PRK00007
859657002080	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
859657002081	G1 box; other site
859657002082	putative GEF interaction site [polypeptide binding]; other site
859657002083	GTP/Mg2+ binding site [chemical binding]; other site
859657002084	Switch I region; other site
859657002085	G2 box; other site
859657002086	G3 box; other site
859657002087	Switch II region; other site
859657002088	G4 box; other site
859657002089	G5 box; other site
859657002090	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
859657002091	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
859657002092	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
859657002093	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
859657002094	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
859657002095	ligand binding site [chemical binding]; other site
859657002096	flexible hinge region; other site
859657002097	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
859657002098	putative switch regulator; other site
859657002099	non-specific DNA interactions [nucleotide binding]; other site
859657002100	DNA binding site [nucleotide binding]
859657002101	sequence specific DNA binding site [nucleotide binding]; other site
859657002102	putative cAMP binding site [chemical binding]; other site
859657002103	Predicted membrane protein [Function unknown]; Region: COG4539
859657002104	Ferredoxin [Energy production and conversion]; Region: COG1146
859657002105	4Fe-4S binding domain; Region: Fer4; pfam00037
859657002106	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
859657002107	Peptidase M30; Region: Peptidase_M30; pfam10460
859657002108	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
859657002109	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
859657002110	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
859657002111	conserved cys residue [active]
859657002112	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
859657002113	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474
859657002114	gamma subunit interface [polypeptide binding]; other site
859657002115	epsilon subunit interface [polypeptide binding]; other site
859657002116	LBP interface [polypeptide binding]; other site
859657002117	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
859657002118	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859657002119	N-terminal plug; other site
859657002120	ligand-binding site [chemical binding]; other site
859657002121	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
859657002122	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657002123	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657002124	metal binding site [ion binding]; metal-binding site
859657002125	active site
859657002126	I-site; other site
859657002127	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657002128	malate:quinone oxidoreductase; Validated; Region: PRK05257
859657002129	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
859657002130	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657002131	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657002132	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
859657002133	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator
859657002134	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
859657002135	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
859657002136	Protein export membrane protein; Region: SecD_SecF; cl14618
859657002137	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657002138	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657002139	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657002140	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
859657002141	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
859657002142	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657002143	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
859657002144	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657002145	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
859657002146	putative dimerization interface [polypeptide binding]; other site
859657002147	putative substrate binding pocket [chemical binding]; other site
859657002148	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
859657002149	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657002150	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657002151	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
859657002152	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
859657002153	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657002154	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657002155	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
859657002156	Isochorismatase family; Region: Isochorismatase; pfam00857
859657002157	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
859657002158	catalytic triad [active]
859657002159	conserved cis-peptide bond; other site
859657002160	Pirin-related protein [General function prediction only]; Region: COG1741
859657002161	Pirin; Region: Pirin; pfam02678
859657002162	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
859657002163	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
859657002164	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
859657002165	FMN binding site [chemical binding]; other site
859657002166	active site
859657002167	substrate binding site [chemical binding]; other site
859657002168	catalytic residue [active]
859657002169	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657002170	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
859657002171	NAD(P) binding site [chemical binding]; other site
859657002172	active site
859657002173	LysR family transcriptional regulator; Provisional; Region: PRK14997
859657002174	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657002175	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657002176	putative effector binding pocket; other site
859657002177	dimerization interface [polypeptide binding]; other site
859657002178	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657002179	S-adenosylmethionine binding site [chemical binding]; other site
859657002180	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
859657002181	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
859657002182	putative active site [active]
859657002183	catalytic residue [active]
859657002184	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
859657002185	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
859657002186	dimer interface [polypeptide binding]; other site
859657002187	NADP binding site [chemical binding]; other site
859657002188	catalytic residues [active]
859657002189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657002190	D-galactonate transporter; Region: 2A0114; TIGR00893
859657002191	putative substrate translocation pore; other site
859657002192	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
859657002193	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
859657002194	active site
859657002195	tetramer interface [polypeptide binding]; other site
859657002196	galactarate dehydratase; Region: galactar-dH20; TIGR03248
859657002197	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
859657002198	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
859657002199	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
859657002200	extended (e) SDRs; Region: SDR_e; cd08946
859657002201	NAD(P) binding site [chemical binding]; other site
859657002202	active site
859657002203	substrate binding site [chemical binding]; other site
859657002204	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
859657002205	Strictosidine synthase; Region: Str_synth; pfam03088
859657002206	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
859657002207	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
859657002208	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657002209	D-galactonate transporter; Region: 2A0114; TIGR00893
859657002210	putative substrate translocation pore; other site
859657002211	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
859657002212	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859657002213	active site
859657002214	nucleotide binding site [chemical binding]; other site
859657002215	HIGH motif; other site
859657002216	KMSKS motif; other site
859657002217	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
859657002218	nudix motif; other site
859657002219	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
859657002220	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
859657002221	active site
859657002222	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
859657002223	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
859657002224	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859657002225	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657002226	dimerization interface [polypeptide binding]; other site
859657002227	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657002228	dimer interface [polypeptide binding]; other site
859657002229	putative CheW interface [polypeptide binding]; other site
859657002230	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859657002231	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859657002232	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859657002233	catalytic residue [active]
859657002234	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
859657002235	Predicted transcriptional regulators [Transcription]; Region: COG1733
859657002236	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
859657002237	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
859657002238	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657002239	NAD(P) binding site [chemical binding]; other site
859657002240	active site
859657002241	RNA polymerase sigma factor; Provisional; Region: PRK12525
859657002242	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657002243	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657002244	DNA binding residues [nucleotide binding]
859657002245	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
859657002246	FecR protein; Region: FecR; pfam04773
859657002247	Protein of unknown function (DUF3160); Region: DUF3160; pfam11369
859657002248	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657002249	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657002250	DNA binding residues [nucleotide binding]
859657002251	dimerization interface [polypeptide binding]; other site
859657002252	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657002253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657002254	active site
859657002255	phosphorylation site [posttranslational modification]
859657002256	intermolecular recognition site; other site
859657002257	dimerization interface [polypeptide binding]; other site
859657002258	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657002259	DNA binding site [nucleotide binding]
859657002260	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
859657002261	Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790
859657002262	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
859657002263	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
859657002264	type III secretion protein HpaP; Region: HpaP; TIGR02557
859657002265	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
859657002266	FHIPEP family; Region: FHIPEP; pfam00771
859657002267	type III secretion system protein HrcU; Validated; Region: PRK09108
859657002268	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
859657002269	type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561
859657002270	type III secretion protein HrpB2; Region: HrpB2; TIGR02558
859657002271	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
859657002272	type III secretion protein HrpB4; Region: HrpB4; TIGR02560
859657002273	Bacterial type III secretion protein (HrpB4); Region: HrpB4; pfam09502
859657002274	type III secretion system protein HrpB; Validated; Region: PRK09098
859657002275	Flagellar assembly protein FliH; Region: FliH; pfam02108
859657002276	type III secretion system ATPase; Provisional; Region: PRK09099
859657002277	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
859657002278	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
859657002279	Walker A motif/ATP binding site; other site
859657002280	Walker B motif; other site
859657002281	Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791
859657002282	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859657002283	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657002284	Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450
859657002285	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859657002286	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859657002287	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859657002288	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
859657002289	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657002290	Leucine-rich repeats; other site
859657002291	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
859657002292	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
859657002293	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859657002294	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
859657002295	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
859657002296	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
859657002297	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
859657002298	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
859657002299	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
859657002300	Interdomain contacts; other site
859657002301	Cytokine receptor motif; other site
859657002302	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
859657002303	SET domain; Region: SET; pfam00856
859657002304	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
859657002305	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
859657002306	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
859657002307	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
859657002308	glutamine synthetase, type I; Region: GlnA; TIGR00653
859657002309	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
859657002310	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
859657002311	Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin
859657002312	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
859657002313	Predicted dehydrogenase [General function prediction only]; Region: COG5322
859657002314	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
859657002315	NAD(P) binding pocket [chemical binding]; other site
859657002316	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
859657002317	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859657002318	inhibitor-cofactor binding pocket; inhibition site
859657002319	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657002320	catalytic residue [active]
859657002321	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
859657002322	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
859657002323	putative Cl- selectivity filter; other site
859657002324	putative pore gating glutamate residue; other site
859657002325	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
859657002326	putative active site pocket [active]
859657002327	dimerization interface [polypeptide binding]; other site
859657002328	putative catalytic residue [active]
859657002329	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859657002330	active site
859657002331	HIGH motif; other site
859657002332	nucleotide binding site [chemical binding]; other site
859657002333	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859657002334	active site
859657002335	KMSKS motif; other site
859657002336	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
859657002337	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
859657002338	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
859657002339	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
859657002340	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
859657002341	active site
859657002342	iron coordination sites [ion binding]; other site
859657002343	substrate binding pocket [chemical binding]; other site
859657002344	Putative methyltransferase; Region: Methyltransf_4; cl17290
859657002345	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
859657002346	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859657002347	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859657002348	catalytic residue [active]
859657002349	Outer membrane efflux protein; Region: OEP; pfam02321
859657002350	Outer membrane efflux protein; Region: OEP; pfam02321
859657002351	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
859657002352	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657002353	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
859657002354	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
859657002355	Uncharacterized conserved protein [Function unknown]; Region: COG5569
859657002356	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
859657002357	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
859657002358	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
859657002359	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
859657002360	Walker A/P-loop; other site
859657002361	ATP binding site [chemical binding]; other site
859657002362	Q-loop/lid; other site
859657002363	ABC transporter signature motif; other site
859657002364	Walker B; other site
859657002365	D-loop; other site
859657002366	H-loop/switch region; other site
859657002367	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
859657002368	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657002369	dimer interface [polypeptide binding]; other site
859657002370	conserved gate region; other site
859657002371	putative PBP binding loops; other site
859657002372	ABC-ATPase subunit interface; other site
859657002373	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
859657002374	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657002375	substrate binding pocket [chemical binding]; other site
859657002376	membrane-bound complex binding site; other site
859657002377	hinge residues; other site
859657002378	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
859657002379	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657002380	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657002381	dimerization interface [polypeptide binding]; other site
859657002382	Lysine efflux permease [General function prediction only]; Region: COG1279
859657002383	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
859657002384	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
859657002385	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
859657002386	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
859657002387	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
859657002388	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
859657002389	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
859657002390	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657002391	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
859657002392	catalytic site [active]
859657002393	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859657002394	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657002395	putative substrate translocation pore; other site
859657002396	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657002397	Uncharacterized conserved protein [Function unknown]; Region: COG5514
859657002398	heme-binding site [chemical binding]; other site
859657002399	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
859657002400	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
859657002401	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
859657002402	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
859657002403	catalytic residues [active]
859657002404	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657002405	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657002406	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657002407	putative effector binding pocket; other site
859657002408	dimerization interface [polypeptide binding]; other site
859657002409	hypothetical protein; Provisional; Region: PRK07236
859657002410	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
859657002411	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
859657002412	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657002413	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
859657002414	dimerization interface [polypeptide binding]; other site
859657002415	substrate binding pocket [chemical binding]; other site
859657002416	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
859657002417	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859657002418	Evidence 2b : Function of strongly homologous gene; Product type ph : phenotype
859657002419	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
859657002420	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
859657002421	putative NAD(P) binding site [chemical binding]; other site
859657002422	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
859657002423	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
859657002424	FMN binding site [chemical binding]; other site
859657002425	active site
859657002426	substrate binding site [chemical binding]; other site
859657002427	catalytic residue [active]
859657002428	short chain dehydrogenase; Validated; Region: PRK08264
859657002429	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657002430	NAD(P) binding site [chemical binding]; other site
859657002431	active site
859657002432	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657002433	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657002434	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657002435	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657002436	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657002437	Leucine-rich repeats; other site
859657002438	Substrate binding site [chemical binding]; other site
859657002439	F-box-like; Region: F-box-like; cl02535
859657002440	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657002441	Leucine-rich repeats; other site
859657002442	Substrate binding site [chemical binding]; other site
859657002443	Leucine rich repeat; Region: LRR_8; pfam13855
859657002444	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657002445	Leucine-rich repeats; other site
859657002446	Substrate binding site [chemical binding]; other site
859657002447	Leucine rich repeat; Region: LRR_8; pfam13855
859657002448	Leucine rich repeat; Region: LRR_8; pfam13855
859657002449	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859657002450	TAP-like protein; Region: Abhydrolase_4; pfam08386
859657002451	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
859657002452	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859657002453	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859657002454	N-terminal plug; other site
859657002455	ligand-binding site [chemical binding]; other site
859657002456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657002457	putative substrate translocation pore; other site
859657002458	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859657002459	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859657002460	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
859657002461	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
859657002462	active site
859657002463	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657002464	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
859657002465	acyl-activating enzyme (AAE) consensus motif; other site
859657002466	AMP binding site [chemical binding]; other site
859657002467	active site
859657002468	CoA binding site [chemical binding]; other site
859657002469	CoA-transferase family III; Region: CoA_transf_3; pfam02515
859657002470	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
859657002471	MoaE interaction surface [polypeptide binding]; other site
859657002472	MoeB interaction surface [polypeptide binding]; other site
859657002473	thiocarboxylated glycine; other site
859657002474	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
859657002475	MPN+ (JAMM) motif; other site
859657002476	Zinc-binding site [ion binding]; other site
859657002477	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
859657002478	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
859657002479	ATP binding site [chemical binding]; other site
859657002480	substrate interface [chemical binding]; other site
859657002481	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
859657002482	active site residue [active]
859657002483	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
859657002484	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
859657002485	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859657002486	catalytic residues [active]
859657002487	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
859657002488	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
859657002489	Small subunit of Arsenite oxidase (ArOX) family, Rieske domain; ArOX is a molybdenum/iron protein involved in the detoxification of arsenic, oxidizing it to arsenate. It consists of two subunits, a large subunit similar to members of the DMSO reductase...; Region: Rieske_ArOX_small; cd03476
859657002490	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
859657002491	[2Fe-2S] cluster binding site [ion binding]; other site
859657002492	subunit interaction site [polypeptide binding]; other site
859657002493	Arsenite oxidase (Arsenite-Ox) oxidizes arsenite to the less toxic arsenate; it transfers the electrons obtained from the oxidation of arsenite towards the soluble periplasmic electron carriers cytochrome c and/or amicyanin.  Arsenite oxidase is a...; Region: MopB_Arsenite-Ox; cd02756
859657002494	arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693
859657002495	[3Fe-4S] binding site [ion binding]; other site
859657002496	molybdopterin cofactor binding site [chemical binding]; other site
859657002497	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
859657002498	molybdopterin cofactor binding site; other site
859657002499	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657002500	dimerization interface [polypeptide binding]; other site
859657002501	putative DNA binding site [nucleotide binding]; other site
859657002502	putative Zn2+ binding site [ion binding]; other site
859657002503	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
859657002504	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859657002505	putative metal binding site [ion binding]; other site
859657002506	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
859657002507	Low molecular weight phosphatase family; Region: LMWPc; cd00115
859657002508	active site
859657002509	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
859657002510	Low molecular weight phosphatase family; Region: LMWPc; cd00115
859657002511	active site
859657002512	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
859657002513	amphipathic channel; other site
859657002514	Asn-Pro-Ala signature motifs; other site
859657002515	Protein of unknown function (DUF3757); Region: DUF3757; pfam12582
859657002516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657002517	putative substrate translocation pore; other site
859657002518	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
859657002519	Evidence 2b : Function of strongly homologous gene; Product type r : regulator
859657002520	Evidence 2b : Function of strongly homologous gene; Product type r : regulator
859657002521	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657002522	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657002523	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
859657002524	putative effector binding pocket; other site
859657002525	putative dimerization interface [polypeptide binding]; other site
859657002526	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657002527	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657002528	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
859657002529	putative effector binding pocket; other site
859657002530	putative dimerization interface [polypeptide binding]; other site
859657002531	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
859657002532	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657002533	putative substrate translocation pore; other site
859657002534	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
859657002535	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
859657002536	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657002537	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
859657002538	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
859657002539	putative NAD(P) binding site [chemical binding]; other site
859657002540	putative substrate binding site [chemical binding]; other site
859657002541	catalytic Zn binding site [ion binding]; other site
859657002542	structural Zn binding site [ion binding]; other site
859657002543	dimer interface [polypeptide binding]; other site
859657002544	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
859657002545	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657002546	catalytic loop [active]
859657002547	iron binding site [ion binding]; other site
859657002548	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
859657002549	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
859657002550	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859657002551	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
859657002552	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859657002553	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
859657002554	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
859657002555	XdhC Rossmann domain; Region: XdhC_C; pfam13478
859657002556	Cytochrome c; Region: Cytochrom_C; cl11414
859657002557	Uncharacterized conserved protein [Function unknown]; Region: COG4925
859657002558	YCII-related domain; Region: YCII; cl00999
859657002559	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
859657002560	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859657002561	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657002562	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657002563	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657002564	putative effector binding pocket; other site
859657002565	dimerization interface [polypeptide binding]; other site
859657002566	Homeodomain-like domain; Region: HTH_23; pfam13384
859657002567	Winged helix-turn helix; Region: HTH_29; pfam13551
859657002568	Homeodomain-like domain; Region: HTH_32; pfam13565
859657002569	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
859657002570	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859657002571	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
859657002572	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
859657002573	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
859657002574	active site
859657002575	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
859657002576	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
859657002577	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
859657002578	hypothetical protein; Validated; Region: PRK09169
859657002579	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cd00598
859657002580	active site
859657002581	CAAX protease self-immunity; Region: Abi; pfam02517
859657002582	hypothetical protein; Validated; Region: PRK09169
859657002583	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
859657002584	synthetase active site [active]
859657002585	NTP binding site [chemical binding]; other site
859657002586	metal binding site [ion binding]; metal-binding site
859657002587	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
859657002588	metal binding triad [ion binding]; metal-binding site
859657002589	Phage integrase protein; Region: DUF3701; pfam12482
859657002590	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
859657002591	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
859657002592	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
859657002593	Int/Topo IB signature motif; other site
859657002594	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
859657002595	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657002596	DNA-binding site [nucleotide binding]; DNA binding site
859657002597	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
859657002598	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
859657002599	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
859657002600	tetramer interface [polypeptide binding]; other site
859657002601	active site
859657002602	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
859657002603	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
859657002604	Spore Coat Protein U domain; Region: SCPU; pfam05229
859657002605	Uncharacterized secreted protein [Function unknown]; Region: COG5430
859657002606	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
859657002607	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
859657002608	PapC C-terminal domain; Region: PapC_C; pfam13953
859657002609	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
859657002610	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
859657002611	Uncharacterized secreted protein [Function unknown]; Region: COG5430
859657002612	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657002613	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657002614	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657002615	DNA binding residues [nucleotide binding]
859657002616	dimerization interface [polypeptide binding]; other site
859657002617	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
859657002618	thiamine phosphate binding site [chemical binding]; other site
859657002619	active site
859657002620	pyrophosphate binding site [ion binding]; other site
859657002621	metabolite-proton symporter; Region: 2A0106; TIGR00883
859657002622	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657002623	putative substrate translocation pore; other site
859657002624	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
859657002625	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
859657002626	putative active site [active]
859657002627	metal binding site [ion binding]; metal-binding site
859657002628	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
859657002629	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
859657002630	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
859657002631	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657002632	Walker A/P-loop; other site
859657002633	ATP binding site [chemical binding]; other site
859657002634	Q-loop/lid; other site
859657002635	ABC transporter signature motif; other site
859657002636	Walker B; other site
859657002637	D-loop; other site
859657002638	H-loop/switch region; other site
859657002639	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657002640	Walker A/P-loop; other site
859657002641	ATP binding site [chemical binding]; other site
859657002642	Q-loop/lid; other site
859657002643	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
859657002644	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
859657002645	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
859657002646	Ligand Binding Site [chemical binding]; other site
859657002647	radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269
859657002648	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657002649	FeS/SAM binding site; other site
859657002650	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
859657002651	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
859657002652	tetramer interface [polypeptide binding]; other site
859657002653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657002654	catalytic residue [active]
859657002655	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
859657002656	Predicted amidohydrolase [General function prediction only]; Region: COG0388
859657002657	putative active site [active]
859657002658	catalytic triad [active]
859657002659	putative dimer interface [polypeptide binding]; other site
859657002660	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
859657002661	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
859657002662	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
859657002663	tartrate dehydrogenase; Region: TTC; TIGR02089
859657002664	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657002665	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657002666	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
859657002667	putative effector binding pocket; other site
859657002668	putative dimerization interface [polypeptide binding]; other site
859657002669	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
859657002670	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
859657002671	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
859657002672	NAD(P) binding site [chemical binding]; other site
859657002673	homodimer interface [polypeptide binding]; other site
859657002674	substrate binding site [chemical binding]; other site
859657002675	active site
859657002676	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
859657002677	active site
859657002678	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
859657002679	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
859657002680	inhibitor-cofactor binding pocket; inhibition site
859657002681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657002682	catalytic residue [active]
859657002683	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
859657002684	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
859657002685	putative trimer interface [polypeptide binding]; other site
859657002686	putative CoA binding site [chemical binding]; other site
859657002687	Bacterial sugar transferase; Region: Bac_transf; pfam02397
859657002688	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859657002689	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
859657002690	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
859657002691	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
859657002692	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
859657002693	putative NAD(P) binding site [chemical binding]; other site
859657002694	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
859657002695	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859657002696	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
859657002697	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
859657002698	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
859657002699	trimer interface [polypeptide binding]; other site
859657002700	active site
859657002701	substrate binding site [chemical binding]; other site
859657002702	CoA binding site [chemical binding]; other site
859657002703	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859657002704	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
859657002705	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_epsE_like; cd13129
859657002706	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
859657002707	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
859657002708	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
859657002709	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
859657002710	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
859657002711	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
859657002712	active site
859657002713	homodimer interface [polypeptide binding]; other site
859657002714	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
859657002715	Chain length determinant protein; Region: Wzz; pfam02706
859657002716	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
859657002717	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
859657002718	Nucleotide binding site [chemical binding]; other site
859657002719	P loop; other site
859657002720	DTAP/Switch II; other site
859657002721	Switch I; other site
859657002722	Low molecular weight phosphatase family; Region: LMWPc; cd00115
859657002723	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
859657002724	active site
859657002725	polysaccharide export protein Wza; Provisional; Region: PRK15078
859657002726	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
859657002727	SLBB domain; Region: SLBB; pfam10531
859657002728	SLBB domain; Region: SLBB; pfam10531
859657002729	Evidence 4 : Homologs of previously reported genes of unknown function
859657002730	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657002731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
859657002732	active site
859657002733	phosphorylation site [posttranslational modification]
859657002734	dimerization interface [polypeptide binding]; other site
859657002735	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657002736	DNA binding site [nucleotide binding]
859657002737	Fic family protein [Function unknown]; Region: COG3177
859657002738	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
859657002739	Fic/DOC family; Region: Fic; pfam02661
859657002740	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
859657002741	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657002742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657002743	ATP binding site [chemical binding]; other site
859657002744	Mg2+ binding site [ion binding]; other site
859657002745	G-X-G motif; other site
859657002746	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
859657002747	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
859657002748	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859657002749	Tar ligand binding domain homologue; Region: TarH; pfam02203
859657002750	HAMP domain; Region: HAMP; pfam00672
859657002751	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657002752	dimer interface [polypeptide binding]; other site
859657002753	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
859657002754	putative CheW interface [polypeptide binding]; other site
859657002755	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
859657002756	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
859657002757	putative di-iron ligands [ion binding]; other site
859657002758	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
859657002759	succinic semialdehyde dehydrogenase; Region: PLN02278
859657002760	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
859657002761	tetramerization interface [polypeptide binding]; other site
859657002762	NAD(P) binding site [chemical binding]; other site
859657002763	catalytic residues [active]
859657002764	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
859657002765	tartrate dehydrogenase; Region: TTC; TIGR02089
859657002766	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
859657002767	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859657002768	Walker A/P-loop; other site
859657002769	ATP binding site [chemical binding]; other site
859657002770	Q-loop/lid; other site
859657002771	ABC transporter signature motif; other site
859657002772	Walker B; other site
859657002773	D-loop; other site
859657002774	H-loop/switch region; other site
859657002775	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859657002776	Walker A/P-loop; other site
859657002777	ATP binding site [chemical binding]; other site
859657002778	Q-loop/lid; other site
859657002779	ABC transporter signature motif; other site
859657002780	Walker B; other site
859657002781	D-loop; other site
859657002782	H-loop/switch region; other site
859657002783	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
859657002784	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
859657002785	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657002786	dimer interface [polypeptide binding]; other site
859657002787	conserved gate region; other site
859657002788	ABC-ATPase subunit interface; other site
859657002789	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
859657002790	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657002791	dimer interface [polypeptide binding]; other site
859657002792	conserved gate region; other site
859657002793	putative PBP binding loops; other site
859657002794	ABC-ATPase subunit interface; other site
859657002795	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
859657002796	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
859657002797	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
859657002798	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
859657002799	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
859657002800	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
859657002801	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859657002802	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
859657002803	NAD(P) binding site [chemical binding]; other site
859657002804	catalytic residues [active]
859657002805	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657002806	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
859657002807	Coenzyme A binding pocket [chemical binding]; other site
859657002808	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
859657002809	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
859657002810	putative ligand binding site [chemical binding]; other site
859657002811	NAD binding site [chemical binding]; other site
859657002812	dimerization interface [polypeptide binding]; other site
859657002813	catalytic site [active]
859657002814	hypothetical protein; Provisional; Region: PRK05965
859657002815	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859657002816	inhibitor-cofactor binding pocket; inhibition site
859657002817	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657002818	catalytic residue [active]
859657002819	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859657002820	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657002821	putative DNA binding site [nucleotide binding]; other site
859657002822	putative Zn2+ binding site [ion binding]; other site
859657002823	AsnC family; Region: AsnC_trans_reg; pfam01037
859657002824	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
859657002825	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
859657002826	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
859657002827	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
859657002828	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
859657002829	F-box-like; Region: F-box-like; cl02535
859657002830	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657002831	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657002832	Leucine-rich repeats; other site
859657002833	Substrate binding site [chemical binding]; other site
859657002834	Leucine rich repeat; Region: LRR_8; pfam13855
859657002835	Leucine rich repeat; Region: LRR_8; pfam13855
859657002836	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657002837	Leucine-rich repeats; other site
859657002838	Substrate binding site [chemical binding]; other site
859657002839	F-box domain; Region: F-box; pfam00646
859657002840	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657002841	Leucine-rich repeats; other site
859657002842	Substrate binding site [chemical binding]; other site
859657002843	Leucine rich repeat; Region: LRR_8; pfam13855
859657002844	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657002845	Leucine-rich repeats; other site
859657002846	Leucine rich repeat; Region: LRR_8; pfam13855
859657002847	Substrate binding site [chemical binding]; other site
859657002848	Leucine rich repeat; Region: LRR_8; pfam13855
859657002849	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
859657002850	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
859657002851	amidase catalytic site [active]
859657002852	Zn binding residues [ion binding]; other site
859657002853	substrate binding site [chemical binding]; other site
859657002854	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
859657002855	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
859657002856	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
859657002857	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
859657002858	metal binding site [ion binding]; metal-binding site
859657002859	putative dimer interface [polypeptide binding]; other site
859657002860	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
859657002861	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
859657002862	Evidence 5 : No homology to any previously reported sequences
859657002863	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
859657002864	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
859657002865	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
859657002866	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
859657002867	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
859657002868	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
859657002869	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
859657002870	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
859657002871	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
859657002872	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
859657002873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
859657002874	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
859657002875	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
859657002876	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
859657002877	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
859657002878	Predicted integral membrane protein [Function unknown]; Region: COG5572
859657002879	hypothetical protein; Provisional; Region: PRK05409
859657002880	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
859657002881	Predicted membrane protein [Function unknown]; Region: COG2259
859657002882	BON domain; Region: BON; pfam04972
859657002883	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859657002884	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
859657002885	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657002886	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657002887	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657002888	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657002889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657002890	active site
859657002891	phosphorylation site [posttranslational modification]
859657002892	intermolecular recognition site; other site
859657002893	dimerization interface [polypeptide binding]; other site
859657002894	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657002895	DNA binding site [nucleotide binding]
859657002896	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657002897	dimerization interface [polypeptide binding]; other site
859657002898	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657002899	dimer interface [polypeptide binding]; other site
859657002900	phosphorylation site [posttranslational modification]
859657002901	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657002902	ATP binding site [chemical binding]; other site
859657002903	Mg2+ binding site [ion binding]; other site
859657002904	G-X-G motif; other site
859657002905	Outer membrane efflux protein; Region: OEP; pfam02321
859657002906	Outer membrane efflux protein; Region: OEP; pfam02321
859657002907	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657002908	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657002909	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657002910	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
859657002911	Hpt domain; Region: Hpt; pfam01627
859657002912	putative binding surface; other site
859657002913	active site
859657002914	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
859657002915	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859657002916	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657002917	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
859657002918	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
859657002919	putative molybdopterin cofactor binding site [chemical binding]; other site
859657002920	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
859657002921	putative molybdopterin cofactor binding site; other site
859657002922	Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526
859657002923	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657002924	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
859657002925	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657002926	putative active site [active]
859657002927	heme pocket [chemical binding]; other site
859657002928	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
859657002929	potassium uptake protein; Region: kup; TIGR00794
859657002930	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
859657002931	DNA-binding site [nucleotide binding]; DNA binding site
859657002932	RNA-binding motif; other site
859657002933	Cold shock proteins [Transcription]; Region: CspC; COG1278
859657002934	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
859657002935	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
859657002936	tetrameric interface [polypeptide binding]; other site
859657002937	NAD binding site [chemical binding]; other site
859657002938	catalytic residues [active]
859657002939	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
859657002940	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859657002941	inhibitor-cofactor binding pocket; inhibition site
859657002942	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657002943	catalytic residue [active]
859657002944	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
859657002945	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657002946	DNA-binding site [nucleotide binding]; DNA binding site
859657002947	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657002948	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657002949	homodimer interface [polypeptide binding]; other site
859657002950	catalytic residue [active]
859657002951	acetoacetate decarboxylase; Provisional; Region: PRK02265
859657002952	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
859657002953	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657002954	NAD(P) binding site [chemical binding]; other site
859657002955	active site
859657002956	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
859657002957	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
859657002958	nucleophile elbow; other site
859657002959	Patatin phospholipase; Region: DUF3734; pfam12536
859657002960	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859657002961	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
859657002962	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
859657002963	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859657002964	N-terminal plug; other site
859657002965	ligand-binding site [chemical binding]; other site
859657002966	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
859657002967	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
859657002968	putative substrate binding site [chemical binding]; other site
859657002969	putative ATP binding site [chemical binding]; other site
859657002970	Pathogenicity factor; Region: AvrE; pfam11725
859657002971	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
859657002972	HPr interaction site; other site
859657002973	glycerol kinase (GK) interaction site [polypeptide binding]; other site
859657002974	active site
859657002975	phosphorylation site [posttranslational modification]
859657002976	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
859657002977	dimerization domain swap beta strand [polypeptide binding]; other site
859657002978	regulatory protein interface [polypeptide binding]; other site
859657002979	active site
859657002980	regulatory phosphorylation site [posttranslational modification]; other site
859657002981	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
859657002982	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
859657002983	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
859657002984	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
859657002985	Maltoporin (phage lambda and maltose receptor) [Carbohydrate transport and metabolism]; Region: LamB; COG4580
859657002986	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
859657002987	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
859657002988	substrate binding [chemical binding]; other site
859657002989	active site
859657002990	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
859657002991	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
859657002992	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
859657002993	active site turn [active]
859657002994	phosphorylation site [posttranslational modification]
859657002995	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
859657002996	Transcriptional regulators [Transcription]; Region: PurR; COG1609
859657002997	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859657002998	DNA binding site [nucleotide binding]
859657002999	domain linker motif; other site
859657003000	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
859657003001	dimerization interface [polypeptide binding]; other site
859657003002	ligand binding site [chemical binding]; other site
859657003003	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component
859657003004	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859657003005	Domain of unknown function (DUF1910); Region: DUF1910; pfam08928
859657003006	Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
859657003007	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859657003008	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859657003009	haemagglutination activity domain; Region: Haemagg_act; pfam05860
859657003010	adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731
859657003011	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
859657003012	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859657003013	RTX toxin acyltransferase family; Region: HlyC; cl01131
859657003014	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
859657003015	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
859657003016	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
859657003017	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657003018	dimerization interface [polypeptide binding]; other site
859657003019	putative DNA binding site [nucleotide binding]; other site
859657003020	putative Zn2+ binding site [ion binding]; other site
859657003021	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
859657003022	Cytochrome P450; Region: p450; cl12078
859657003023	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
859657003024	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
859657003025	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859657003026	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
859657003027	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
859657003028	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
859657003029	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657003030	Walker A motif; other site
859657003031	ATP binding site [chemical binding]; other site
859657003032	Walker B motif; other site
859657003033	arginine finger; other site
859657003034	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859657003035	Predicted membrane protein [Function unknown]; Region: COG4655
859657003036	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
859657003037	Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
859657003038	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
859657003039	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
859657003040	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859657003041	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
859657003042	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859657003043	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
859657003044	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
859657003045	ATP binding site [chemical binding]; other site
859657003046	Walker A motif; other site
859657003047	hexamer interface [polypeptide binding]; other site
859657003048	Walker B motif; other site
859657003049	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
859657003050	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
859657003051	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
859657003052	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859657003053	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
859657003054	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
859657003055	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
859657003056	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
859657003057	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
859657003058	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
859657003059	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657003060	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657003061	DNA binding residues [nucleotide binding]
859657003062	dimerization interface [polypeptide binding]; other site
859657003063	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657003064	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657003065	metal binding site [ion binding]; metal-binding site
859657003066	active site
859657003067	I-site; other site
859657003068	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657003069	H-NS histone family; Region: Histone_HNS; pfam00816
859657003070	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
859657003071	Cache domain; Region: Cache_2; pfam08269
859657003072	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657003073	dimer interface [polypeptide binding]; other site
859657003074	putative CheW interface [polypeptide binding]; other site
859657003075	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657003076	PAS fold; Region: PAS_3; pfam08447
859657003077	putative active site [active]
859657003078	heme pocket [chemical binding]; other site
859657003079	UDP-glucose 4-epimerase; Region: PLN02240
859657003080	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
859657003081	NAD binding site [chemical binding]; other site
859657003082	homodimer interface [polypeptide binding]; other site
859657003083	active site
859657003084	substrate binding site [chemical binding]; other site
859657003085	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
859657003086	active site
859657003087	Int/Topo IB signature motif; other site
859657003088	catalytic residues [active]
859657003089	DNA binding site [nucleotide binding]
859657003090	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
859657003091	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859657003092	active site
859657003093	motif I; other site
859657003094	motif II; other site
859657003095	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
859657003096	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
859657003097	active site
859657003098	homotetramer interface [polypeptide binding]; other site
859657003099	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859657003100	MarR family; Region: MarR; pfam01047
859657003101	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
859657003102	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
859657003103	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
859657003104	substrate binding pocket [chemical binding]; other site
859657003105	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
859657003106	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
859657003107	Uncharacterized conserved protein [Function unknown]; Region: COG1656
859657003108	Protein of unknown function DUF82; Region: DUF82; pfam01927
859657003109	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657003110	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657003111	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
859657003112	putative effector binding pocket; other site
859657003113	putative dimerization interface [polypeptide binding]; other site
859657003114	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
859657003115	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
859657003116	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657003117	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657003118	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859657003119	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859657003120	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859657003121	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
859657003122	catalytic site [active]
859657003123	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
859657003124	ATP adenylyltransferase; Region: ATP_transf; pfam09830
859657003125	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
859657003126	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
859657003127	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
859657003128	active site flap/lid [active]
859657003129	nucleophilic elbow; other site
859657003130	catalytic triad [active]
859657003131	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859657003132	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657003133	dimerization interface [polypeptide binding]; other site
859657003134	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657003135	dimer interface [polypeptide binding]; other site
859657003136	putative CheW interface [polypeptide binding]; other site
859657003137	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
859657003138	nudix motif; other site
859657003139	Evidence 4 : Homologs of previously reported genes of unknown function
859657003140	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
859657003141	Domain of unknown function (DUF4284); Region: DUF4284; pfam14112
859657003142	PAAR motif; Region: PAAR_motif; pfam05488
859657003143	RHS Repeat; Region: RHS_repeat; pfam05593
859657003144	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859657003145	RHS Repeat; Region: RHS_repeat; pfam05593
859657003146	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
859657003147	RHS Repeat; Region: RHS_repeat; pfam05593
859657003148	RHS Repeat; Region: RHS_repeat; pfam05593
859657003149	RHS Repeat; Region: RHS_repeat; cl11982
859657003150	RHS Repeat; Region: RHS_repeat; pfam05593
859657003151	RHS Repeat; Region: RHS_repeat; pfam05593
859657003152	RHS Repeat; Region: RHS_repeat; pfam05593
859657003153	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859657003154	Uncharacterized conserved protein [Function unknown]; Region: COG5435
859657003155	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859657003156	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859657003157	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859657003158	hypothetical protein; Provisional; Region: PRK09946
859657003159	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
859657003160	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657003161	substrate binding pocket [chemical binding]; other site
859657003162	membrane-bound complex binding site; other site
859657003163	hinge residues; other site
859657003164	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657003165	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657003166	DNA binding residues [nucleotide binding]
859657003167	dimerization interface [polypeptide binding]; other site
859657003168	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657003169	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657003170	DNA binding residues [nucleotide binding]
859657003171	benzoate transport; Region: 2A0115; TIGR00895
859657003172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657003173	putative substrate translocation pore; other site
859657003174	hypothetical protein; Provisional; Region: PRK05463
859657003175	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
859657003176	glutaminase; Provisional; Region: PRK00971
859657003177	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657003178	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657003179	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
859657003180	dimerization interface [polypeptide binding]; other site
859657003181	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
859657003182	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657003183	putative PBP binding loops; other site
859657003184	dimer interface [polypeptide binding]; other site
859657003185	ABC-ATPase subunit interface; other site
859657003186	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657003187	Walker A/P-loop; other site
859657003188	ATP binding site [chemical binding]; other site
859657003189	ABC transporter; Region: ABC_tran; pfam00005
859657003190	Q-loop/lid; other site
859657003191	ABC transporter signature motif; other site
859657003192	AAA domain; Region: AAA_21; pfam13304
859657003193	Walker B; other site
859657003194	D-loop; other site
859657003195	H-loop/switch region; other site
859657003196	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein
859657003197	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
859657003198	molybdenum-pterin binding domain; Region: Mop; TIGR00638
859657003199	PAS domain S-box; Region: sensory_box; TIGR00229
859657003200	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657003201	putative active site [active]
859657003202	heme pocket [chemical binding]; other site
859657003203	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
859657003204	PAS domain S-box; Region: sensory_box; TIGR00229
859657003205	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657003206	putative active site [active]
859657003207	heme pocket [chemical binding]; other site
859657003208	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657003209	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657003210	metal binding site [ion binding]; metal-binding site
859657003211	active site
859657003212	I-site; other site
859657003213	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657003214	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859657003215	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657003216	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
859657003217	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
859657003218	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859657003219	Ligand Binding Site [chemical binding]; other site
859657003220	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
859657003221	dimer interface [polypeptide binding]; other site
859657003222	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
859657003223	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657003224	active site
859657003225	phosphorylation site [posttranslational modification]
859657003226	intermolecular recognition site; other site
859657003227	dimerization interface [polypeptide binding]; other site
859657003228	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657003229	DNA binding site [nucleotide binding]
859657003230	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657003231	dimerization interface [polypeptide binding]; other site
859657003232	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657003233	dimer interface [polypeptide binding]; other site
859657003234	phosphorylation site [posttranslational modification]
859657003235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657003236	ATP binding site [chemical binding]; other site
859657003237	Mg2+ binding site [ion binding]; other site
859657003238	G-X-G motif; other site
859657003239	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657003240	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657003241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
859657003242	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
859657003243	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
859657003244	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
859657003245	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859657003246	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
859657003247	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859657003248	active site
859657003249	metal binding site [ion binding]; metal-binding site
859657003250	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
859657003251	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
859657003252	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
859657003253	Transporter associated domain; Region: CorC_HlyC; pfam03471
859657003254	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
859657003255	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
859657003256	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
859657003257	Dodecin; Region: Dodecin; pfam07311
859657003258	Evidence 4 : Homologs of previously reported genes of unknown function
859657003259	H+ Antiporter protein; Region: 2A0121; TIGR00900
859657003260	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657003261	putative substrate translocation pore; other site
859657003262	PAS domain; Region: PAS_9; pfam13426
859657003263	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657003264	putative active site [active]
859657003265	heme pocket [chemical binding]; other site
859657003266	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657003267	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657003268	dimer interface [polypeptide binding]; other site
859657003269	phosphorylation site [posttranslational modification]
859657003270	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657003271	ATP binding site [chemical binding]; other site
859657003272	Mg2+ binding site [ion binding]; other site
859657003273	G-X-G motif; other site
859657003274	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859657003275	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657003276	active site
859657003277	phosphorylation site [posttranslational modification]
859657003278	intermolecular recognition site; other site
859657003279	dimerization interface [polypeptide binding]; other site
859657003280	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
859657003281	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
859657003282	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
859657003283	active site
859657003284	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
859657003285	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
859657003286	substrate binding site [chemical binding]; other site
859657003287	ATP binding site [chemical binding]; other site
859657003288	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
859657003289	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
859657003290	dimer interface [polypeptide binding]; other site
859657003291	active site
859657003292	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859657003293	substrate binding site [chemical binding]; other site
859657003294	catalytic residue [active]
859657003295	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
859657003296	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
859657003297	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
859657003298	putative active site [active]
859657003299	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
859657003300	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
859657003301	active site
859657003302	putative substrate binding pocket [chemical binding]; other site
859657003303	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859657003304	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
859657003305	homotrimer interaction site [polypeptide binding]; other site
859657003306	putative active site [active]
859657003307	GntP family permease; Region: GntP_permease; pfam02447
859657003308	fructuronate transporter; Provisional; Region: PRK10034; cl15264
859657003309	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
859657003310	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
859657003311	active site
859657003312	intersubunit interface [polypeptide binding]; other site
859657003313	catalytic residue [active]
859657003314	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
859657003315	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
859657003316	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657003317	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657003318	DNA binding residues [nucleotide binding]
859657003319	dimerization interface [polypeptide binding]; other site
859657003320	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
859657003321	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
859657003322	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
859657003323	Domain of unknown function (DUF333); Region: DUF333; pfam03891
859657003324	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657003325	dimerization interface [polypeptide binding]; other site
859657003326	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
859657003327	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657003328	dimer interface [polypeptide binding]; other site
859657003329	phosphorylation site [posttranslational modification]
859657003330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657003331	ATP binding site [chemical binding]; other site
859657003332	Mg2+ binding site [ion binding]; other site
859657003333	G-X-G motif; other site
859657003334	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657003335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657003336	active site
859657003337	phosphorylation site [posttranslational modification]
859657003338	intermolecular recognition site; other site
859657003339	dimerization interface [polypeptide binding]; other site
859657003340	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657003341	DNA binding site [nucleotide binding]
859657003342	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657003343	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657003344	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657003345	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
859657003346	Protein export membrane protein; Region: SecD_SecF; cl14618
859657003347	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
859657003348	Protein export membrane protein; Region: SecD_SecF; cl14618
859657003349	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859657003350	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
859657003351	PAS domain S-box; Region: sensory_box; TIGR00229
859657003352	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657003353	putative active site [active]
859657003354	heme pocket [chemical binding]; other site
859657003355	PAS fold; Region: PAS_3; pfam08447
859657003356	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657003357	putative active site [active]
859657003358	heme pocket [chemical binding]; other site
859657003359	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657003360	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657003361	metal binding site [ion binding]; metal-binding site
859657003362	active site
859657003363	I-site; other site
859657003364	Flagellar protein YcgR; Region: YcgR_2; pfam12945
859657003365	PilZ domain; Region: PilZ; pfam07238
859657003366	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
859657003367	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
859657003368	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
859657003369	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657003370	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657003371	metal binding site [ion binding]; metal-binding site
859657003372	active site
859657003373	I-site; other site
859657003374	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657003375	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
859657003376	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657003377	dimerization interface [polypeptide binding]; other site
859657003378	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657003379	dimer interface [polypeptide binding]; other site
859657003380	putative CheW interface [polypeptide binding]; other site
859657003381	Predicted small secreted protein [Function unknown]; Region: COG5510
859657003382	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
859657003383	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859657003384	putative active site [active]
859657003385	catalytic site [active]
859657003386	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859657003387	putative active site [active]
859657003388	catalytic site [active]
859657003389	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
859657003390	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
859657003391	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
859657003392	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
859657003393	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
859657003394	[4Fe-4S] binding site [ion binding]; other site
859657003395	molybdopterin cofactor binding site; other site
859657003396	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
859657003397	molybdopterin cofactor binding site; other site
859657003398	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
859657003399	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
859657003400	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859657003401	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
859657003402	nitrite reductase subunit NirD; Provisional; Region: PRK14989
859657003403	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859657003404	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859657003405	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
859657003406	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
859657003407	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
859657003408	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657003409	putative substrate translocation pore; other site
859657003410	PAS domain; Region: PAS_9; pfam13426
859657003411	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657003412	putative active site [active]
859657003413	heme pocket [chemical binding]; other site
859657003414	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
859657003415	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657003416	dimer interface [polypeptide binding]; other site
859657003417	putative CheW interface [polypeptide binding]; other site
859657003418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657003419	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
859657003420	active site
859657003421	phosphorylation site [posttranslational modification]
859657003422	intermolecular recognition site; other site
859657003423	dimerization interface [polypeptide binding]; other site
859657003424	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859657003425	Zn2+ binding site [ion binding]; other site
859657003426	Mg2+ binding site [ion binding]; other site
859657003427	Isopentenyl transferase; Region: IPT; pfam01745
859657003428	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
859657003429	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
859657003430	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
859657003431	active site
859657003432	catalytic site [active]
859657003433	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657003434	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
859657003435	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
859657003436	dimer interface [polypeptide binding]; other site
859657003437	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859657003438	metal binding site [ion binding]; metal-binding site
859657003439	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
859657003440	aspartate aminotransferase; Provisional; Region: PRK05764
859657003441	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657003442	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657003443	homodimer interface [polypeptide binding]; other site
859657003444	catalytic residue [active]
859657003445	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
859657003446	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
859657003447	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
859657003448	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657003449	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
859657003450	dimerization interface [polypeptide binding]; other site
859657003451	substrate binding pocket [chemical binding]; other site
859657003452	hypothetical protein; Validated; Region: PRK09169
859657003453	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
859657003454	metal binding triad [ion binding]; metal-binding site
859657003455	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
859657003456	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657003457	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657003458	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657003459	dimerization interface [polypeptide binding]; other site
859657003460	Uncharacterized conserved protein [Function unknown]; Region: COG2353
859657003461	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
859657003462	Transglycosylase SLT domain; Region: SLT_2; pfam13406
859657003463	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859657003464	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859657003465	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
859657003466	Predicted transcriptional regulators [Transcription]; Region: COG1510
859657003467	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657003468	dimerization interface [polypeptide binding]; other site
859657003469	putative DNA binding site [nucleotide binding]; other site
859657003470	putative Zn2+ binding site [ion binding]; other site
859657003471	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
859657003472	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
859657003473	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
859657003474	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
859657003475	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
859657003476	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
859657003477	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
859657003478	active site
859657003479	catalytic triad [active]
859657003480	oxyanion hole [active]
859657003481	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
859657003482	homotrimer interaction site [polypeptide binding]; other site
859657003483	putative active site [active]
859657003484	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859657003485	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
859657003486	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
859657003487	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
859657003488	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859657003489	active site
859657003490	metal binding site [ion binding]; metal-binding site
859657003491	PGDYG protein; Region: PGDYG; pfam14083
859657003492	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859657003493	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657003494	non-specific DNA binding site [nucleotide binding]; other site
859657003495	salt bridge; other site
859657003496	sequence-specific DNA binding site [nucleotide binding]; other site
859657003497	HipA N-terminal domain; Region: Couple_hipA; pfam13657
859657003498	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
859657003499	HipA-like N-terminal domain; Region: HipA_N; pfam07805
859657003500	HipA-like C-terminal domain; Region: HipA_C; pfam07804
859657003501	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
859657003502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657003503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657003504	LysR family transcriptional regulator; Provisional; Region: PRK14997
859657003505	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657003506	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
859657003507	putative effector binding pocket; other site
859657003508	putative dimerization interface [polypeptide binding]; other site
859657003509	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
859657003510	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859657003511	Evidence 4 : Homologs of previously reported genes of unknown function
859657003512	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
859657003513	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
859657003514	L-aspartate oxidase; Provisional; Region: PRK06175
859657003515	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
859657003516	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
859657003517	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
859657003518	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
859657003519	active site
859657003520	acyl-activating enzyme (AAE) consensus motif; other site
859657003521	putative CoA binding site [chemical binding]; other site
859657003522	AMP binding site [chemical binding]; other site
859657003523	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657003524	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657003525	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
859657003526	putative dimerization interface [polypeptide binding]; other site
859657003527	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
859657003528	Archaeal ATPase; Region: Arch_ATPase; pfam01637
859657003529	Conserved TM helix; Region: TM_helix; pfam05552
859657003530	Conserved TM helix; Region: TM_helix; pfam05552
859657003531	hypothetical protein; Provisional; Region: PRK02237
859657003532	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
859657003533	Family description; Region: UvrD_C_2; pfam13538
859657003534	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
859657003535	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
859657003536	Surface antigen; Region: Bac_surface_Ag; pfam01103
859657003537	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
859657003538	putative transporter; Provisional; Region: PRK10504
859657003539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657003540	putative substrate translocation pore; other site
859657003541	fumarate hydratase; Reviewed; Region: fumC; PRK00485
859657003542	Class II fumarases; Region: Fumarase_classII; cd01362
859657003543	active site
859657003544	tetramer interface [polypeptide binding]; other site
859657003545	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
859657003546	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
859657003547	legume lectins; Region: lectin_L-type; cl14058
859657003548	homotetramer interaction site [polypeptide binding]; other site
859657003549	carbohydrate binding site [chemical binding]; other site
859657003550	metal binding site [ion binding]; metal-binding site
859657003551	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
859657003552	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
859657003553	PilX N-terminal; Region: PilX_N; pfam14341
859657003554	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
859657003555	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
859657003556	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
859657003557	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
859657003558	Type II transport protein GspH; Region: GspH; pfam12019
859657003559	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
859657003560	Walker A motif; other site
859657003561	S-adenosylmethionine decarboxylase [Amino acid transport and metabolism]; Region: SpeD; COG1586
859657003562	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
859657003563	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
859657003564	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
859657003565	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
859657003566	Short C-terminal domain; Region: SHOCT; pfam09851
859657003567	Predicted membrane protein [Function unknown]; Region: COG3766
859657003568	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
859657003569	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859657003570	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
859657003571	putative ligand binding site [chemical binding]; other site
859657003572	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859657003573	TM-ABC transporter signature motif; other site
859657003574	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859657003575	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859657003576	TM-ABC transporter signature motif; other site
859657003577	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859657003578	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859657003579	Walker A/P-loop; other site
859657003580	ATP binding site [chemical binding]; other site
859657003581	Q-loop/lid; other site
859657003582	ABC transporter signature motif; other site
859657003583	Walker B; other site
859657003584	D-loop; other site
859657003585	H-loop/switch region; other site
859657003586	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859657003587	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859657003588	Walker A/P-loop; other site
859657003589	ATP binding site [chemical binding]; other site
859657003590	Q-loop/lid; other site
859657003591	ABC transporter signature motif; other site
859657003592	Walker B; other site
859657003593	D-loop; other site
859657003594	H-loop/switch region; other site
859657003595	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
859657003596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657003597	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
859657003598	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
859657003599	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
859657003600	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
859657003601	Predicted membrane protein [Function unknown]; Region: COG3759
859657003602	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859657003603	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
859657003604	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
859657003605	putative N-terminal domain interface [polypeptide binding]; other site
859657003606	putative dimer interface [polypeptide binding]; other site
859657003607	putative substrate binding pocket (H-site) [chemical binding]; other site
859657003608	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
859657003609	ligand-binding site [chemical binding]; other site
859657003610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657003611	binding surface
859657003612	TPR motif; other site
859657003613	Tetratricopeptide repeat; Region: TPR_12; pfam13424
859657003614	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657003615	binding surface
859657003616	TPR motif; other site
859657003617	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657003618	binding surface
859657003619	TPR motif; other site
859657003620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657003621	TPR motif; other site
859657003622	binding surface
859657003623	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
859657003624	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
859657003625	Autotransporter beta-domain; Region: Autotransporter; pfam03797
859657003626	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657003627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657003628	active site
859657003629	phosphorylation site [posttranslational modification]
859657003630	intermolecular recognition site; other site
859657003631	dimerization interface [polypeptide binding]; other site
859657003632	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657003633	DNA binding residues [nucleotide binding]
859657003634	dimerization interface [polypeptide binding]; other site
859657003635	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
859657003636	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
859657003637	Protein of unknown function (DUF3886); Region: DUF3886; pfam13025
859657003638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657003639	ATP binding site [chemical binding]; other site
859657003640	Mg2+ binding site [ion binding]; other site
859657003641	G-X-G motif; other site
859657003642	hypothetical protein; Validated; Region: PRK09169
859657003643	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
859657003644	metal binding triad [ion binding]; metal-binding site
859657003645	Cupin domain; Region: Cupin_2; cl17218
859657003646	mercuric reductase; Validated; Region: PRK06370
859657003647	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859657003648	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859657003649	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
859657003650	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
859657003651	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
859657003652	PhnA protein; Region: PhnA; pfam03831
859657003653	Evidence 4 : Homologs of previously reported genes of unknown function
859657003654	Transposase; Region: DEDD_Tnp_IS110; pfam01548
859657003655	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
859657003656	phosphate acetyltransferase; Provisional; Region: PRK11890
859657003657	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
859657003658	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
859657003659	propionate/acetate kinase; Provisional; Region: PRK12379
859657003660	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
859657003661	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
859657003662	NAD binding site [chemical binding]; other site
859657003663	homotetramer interface [polypeptide binding]; other site
859657003664	homodimer interface [polypeptide binding]; other site
859657003665	substrate binding site [chemical binding]; other site
859657003666	active site
859657003667	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
859657003668	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
859657003669	transmembrane helices; other site
859657003670	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
859657003671	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657003672	substrate binding pocket [chemical binding]; other site
859657003673	membrane-bound complex binding site; other site
859657003674	hinge residues; other site
859657003675	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype
859657003676	YGGT family; Region: YGGT; pfam02325
859657003677	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator
859657003678	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
859657003679	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
859657003680	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
859657003681	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657003682	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
859657003683	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657003684	DNA binding residues [nucleotide binding]
859657003685	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
859657003686	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
859657003687	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
859657003688	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
859657003689	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
859657003690	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
859657003691	FHIPEP family; Region: FHIPEP; pfam00771
859657003692	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
859657003693	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
859657003694	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657003695	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657003696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657003697	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859657003698	putative substrate translocation pore; other site
859657003699	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
859657003700	Dehydroquinase class II; Region: DHquinase_II; pfam01220
859657003701	active site
859657003702	trimer interface [polypeptide binding]; other site
859657003703	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
859657003704	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
859657003705	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
859657003706	shikimate binding site; other site
859657003707	NAD(P) binding site [chemical binding]; other site
859657003708	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657003709	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657003710	trimer interface [polypeptide binding]; other site
859657003711	eyelet of channel; other site
859657003712	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
859657003713	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
859657003714	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
859657003715	dimer interface [polypeptide binding]; other site
859657003716	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
859657003717	active site
859657003718	Fe binding site [ion binding]; other site
859657003719	chemotaxis regulator CheZ; Provisional; Region: PRK11166
859657003720	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
859657003721	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657003722	active site
859657003723	phosphorylation site [posttranslational modification]
859657003724	intermolecular recognition site; other site
859657003725	dimerization interface [polypeptide binding]; other site
859657003726	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
859657003727	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657003728	active site
859657003729	phosphorylation site [posttranslational modification]
859657003730	intermolecular recognition site; other site
859657003731	dimerization interface [polypeptide binding]; other site
859657003732	CheB methylesterase; Region: CheB_methylest; pfam01339
859657003733	CheD chemotactic sensory transduction; Region: CheD; cl00810
859657003734	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
859657003735	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
859657003736	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657003737	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859657003738	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
859657003739	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657003740	dimerization interface [polypeptide binding]; other site
859657003741	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657003742	dimer interface [polypeptide binding]; other site
859657003743	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
859657003744	putative CheW interface [polypeptide binding]; other site
859657003745	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
859657003746	putative CheA interaction surface; other site
859657003747	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
859657003748	putative binding surface; other site
859657003749	active site
859657003750	CheY binding; Region: CheY-binding; pfam09078
859657003751	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
859657003752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657003753	ATP binding site [chemical binding]; other site
859657003754	Mg2+ binding site [ion binding]; other site
859657003755	G-X-G motif; other site
859657003756	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
859657003757	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859657003758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657003759	active site
859657003760	phosphorylation site [posttranslational modification]
859657003761	intermolecular recognition site; other site
859657003762	dimerization interface [polypeptide binding]; other site
859657003763	flagellar motor protein MotB; Validated; Region: motB; PRK09041
859657003764	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
859657003765	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
859657003766	ligand binding site [chemical binding]; other site
859657003767	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
859657003768	flagellar motor protein MotA; Validated; Region: PRK09110
859657003769	transcriptional activator FlhC; Provisional; Region: PRK12722
859657003770	transcriptional activator FlhD; Provisional; Region: PRK02909
859657003771	Predicted periplasmic protein [Function unknown]; Region: COG3904
859657003772	Uncharacterized conserved protein [Function unknown]; Region: COG4104
859657003773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859657003774	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859657003775	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859657003776	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859657003777	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859657003778	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
859657003779	CoA-transferase family III; Region: CoA_transf_3; pfam02515
859657003780	protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367
859657003781	The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950
859657003782	putative active site [active]
859657003783	Fe(II) binding site [ion binding]; other site
859657003784	putative dimer interface [polypeptide binding]; other site
859657003785	The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923
859657003786	putative dimer interface [polypeptide binding]; other site
859657003787	putative N- and C-terminal domain interface [polypeptide binding]; other site
859657003788	benzoate transport; Region: 2A0115; TIGR00895
859657003789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657003790	putative substrate translocation pore; other site
859657003791	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657003792	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657003793	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
859657003794	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
859657003795	putative dimerization interface [polypeptide binding]; other site
859657003796	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
859657003797	Amidohydrolase; Region: Amidohydro_2; pfam04909
859657003798	hypothetical protein; Provisional; Region: PRK09262
859657003799	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657003800	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657003801	trimer interface [polypeptide binding]; other site
859657003802	eyelet of channel; other site
859657003803	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
859657003804	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
859657003805	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657003806	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657003807	dimerization interface [polypeptide binding]; other site
859657003808	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657003809	dimer interface [polypeptide binding]; other site
859657003810	phosphorylation site [posttranslational modification]
859657003811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657003812	ATP binding site [chemical binding]; other site
859657003813	Mg2+ binding site [ion binding]; other site
859657003814	G-X-G motif; other site
859657003815	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657003816	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657003817	active site
859657003818	phosphorylation site [posttranslational modification]
859657003819	intermolecular recognition site; other site
859657003820	dimerization interface [polypeptide binding]; other site
859657003821	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657003822	DNA binding site [nucleotide binding]
859657003823	Uncharacterized protein conserved in bacteria with a cystatin-like fold [Function unknown]; Region: COG4875
859657003824	SnoaL-like domain; Region: SnoaL_3; pfam13474
859657003825	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
859657003826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657003827	S-adenosylmethionine binding site [chemical binding]; other site
859657003828	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657003829	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
859657003830	putative ligand binding site [chemical binding]; other site
859657003831	pyruvate kinase; Provisional; Region: PRK06247
859657003832	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
859657003833	domain interfaces; other site
859657003834	active site
859657003835	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
859657003836	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
859657003837	MOFRL family; Region: MOFRL; pfam05161
859657003838	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657003839	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657003840	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
859657003841	dimerization interface [polypeptide binding]; other site
859657003842	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype
859657003843	Outer membrane efflux protein; Region: OEP; pfam02321
859657003844	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657003845	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657003846	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657003847	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
859657003848	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
859657003849	Walker A/P-loop; other site
859657003850	ATP binding site [chemical binding]; other site
859657003851	Q-loop/lid; other site
859657003852	ABC transporter signature motif; other site
859657003853	Walker B; other site
859657003854	D-loop; other site
859657003855	H-loop/switch region; other site
859657003856	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
859657003857	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
859657003858	FtsX-like permease family; Region: FtsX; pfam02687
859657003859	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
859657003860	Evidence 4 : Homologs of previously reported genes of unknown function
859657003861	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657003862	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657003863	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
859657003864	putative effector binding pocket; other site
859657003865	putative dimerization interface [polypeptide binding]; other site
859657003866	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
859657003867	Integrase core domain; Region: rve; pfam00665
859657003868	Integrase core domain; Region: rve_3; pfam13683
859657003869	Transposase; Region: HTH_Tnp_1; cl17663
859657003870	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
859657003871	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
859657003872	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
859657003873	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
859657003874	active site
859657003875	catalytic tetrad [active]
859657003876	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
859657003877	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
859657003878	putative NAD(P) binding site [chemical binding]; other site
859657003879	putative substrate binding site [chemical binding]; other site
859657003880	catalytic Zn binding site [ion binding]; other site
859657003881	structural Zn binding site [ion binding]; other site
859657003882	dimer interface [polypeptide binding]; other site
859657003883	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859657003884	CHRD domain; Region: CHRD; pfam07452
859657003885	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
859657003886	GYD domain; Region: GYD; cl01743
859657003887	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
859657003888	dimer interface [polypeptide binding]; other site
859657003889	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657003890	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
859657003891	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
859657003892	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657003893	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657003894	Transposase domain (DUF772); Region: DUF772; pfam05598
859657003895	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657003896	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
859657003897	Coenzyme A binding pocket [chemical binding]; other site
859657003898	Predicted peptidase [General function prediction only]; Region: COG4099
859657003899	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
859657003900	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
859657003901	DNA-binding site [nucleotide binding]; DNA binding site
859657003902	RNA-binding motif; other site
859657003903	Evidence 4 : Homologs of previously reported genes of unknown function
859657003904	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
859657003905	rRNA binding site [nucleotide binding]; other site
859657003906	predicted 30S ribosome binding site; other site
859657003907	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
859657003908	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
859657003909	Methyltransferase domain; Region: Methyltransf_23; pfam13489
859657003910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657003911	S-adenosylmethionine binding site [chemical binding]; other site
859657003912	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
859657003913	RibD C-terminal domain; Region: RibD_C; cl17279
859657003914	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
859657003915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657003916	NAD(P) binding site [chemical binding]; other site
859657003917	active site
859657003918	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657003919	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657003920	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
859657003921	putative effector binding pocket; other site
859657003922	putative dimerization interface [polypeptide binding]; other site
859657003923	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
859657003924	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
859657003925	putative active site [active]
859657003926	putative FMN binding site [chemical binding]; other site
859657003927	putative substrate binding site [chemical binding]; other site
859657003928	putative catalytic residue [active]
859657003929	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
859657003930	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
859657003931	DNA binding residues [nucleotide binding]
859657003932	Evidence 4 : Homologs of previously reported genes of unknown function
859657003933	Evidence 4 : Homologs of previously reported genes of unknown function
859657003934	Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
859657003935	Domain of unknown function (DUF802); Region: DUF802; pfam05650
859657003936	Domain of unknown function (DUF802); Region: DUF802; pfam05650
859657003937	hypothetical protein; Provisional; Region: PRK09040
859657003938	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
859657003939	ligand binding site [chemical binding]; other site
859657003940	Protein of unknown function (DUF2894); Region: DUF2894; pfam11445
859657003941	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859657003942	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
859657003943	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657003944	catalytic loop [active]
859657003945	iron binding site [ion binding]; other site
859657003946	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
859657003947	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
859657003948	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859657003949	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859657003950	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
859657003951	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
859657003952	active site
859657003953	catalytic tetrad [active]
859657003954	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
859657003955	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657003956	catalytic site [active]
859657003957	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8463265; Product type e : enzyme
859657003958	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8463265; Product type e : enzyme
859657003959	Predicted flavoprotein [General function prediction only]; Region: COG0431
859657003960	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859657003961	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
859657003962	NnrS protein; Region: NnrS; pfam05940
859657003963	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859657003964	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859657003965	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
859657003966	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
859657003967	putative acyl-acceptor binding pocket; other site
859657003968	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657003969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657003970	active site
859657003971	phosphorylation site [posttranslational modification]
859657003972	intermolecular recognition site; other site
859657003973	dimerization interface [polypeptide binding]; other site
859657003974	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657003975	DNA binding residues [nucleotide binding]
859657003976	dimerization interface [polypeptide binding]; other site
859657003977	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
859657003978	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
859657003979	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657003980	dimerization interface [polypeptide binding]; other site
859657003981	GAF domain; Region: GAF_3; pfam13492
859657003982	Histidine kinase; Region: HisKA_3; pfam07730
859657003983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657003984	ATP binding site [chemical binding]; other site
859657003985	Mg2+ binding site [ion binding]; other site
859657003986	G-X-G motif; other site
859657003987	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
859657003988	Walker A motif; other site
859657003989	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
859657003990	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
859657003991	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
859657003992	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
859657003993	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
859657003994	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
859657003995	[4Fe-4S] binding site [ion binding]; other site
859657003996	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
859657003997	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
859657003998	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
859657003999	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
859657004000	molybdopterin cofactor binding site; other site
859657004001	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
859657004002	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
859657004003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657004004	putative substrate translocation pore; other site
859657004005	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
859657004006	ATP cone domain; Region: ATP-cone; pfam03477
859657004007	Class III ribonucleotide reductase; Region: RNR_III; cd01675
859657004008	effector binding site; other site
859657004009	active site
859657004010	Zn binding site [ion binding]; other site
859657004011	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
859657004012	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
859657004013	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657004014	FeS/SAM binding site; other site
859657004015	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
859657004016	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
859657004017	ligand binding site [chemical binding]; other site
859657004018	flexible hinge region; other site
859657004019	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
859657004020	putative switch regulator; other site
859657004021	non-specific DNA interactions [nucleotide binding]; other site
859657004022	DNA binding site [nucleotide binding]
859657004023	sequence specific DNA binding site [nucleotide binding]; other site
859657004024	putative cAMP binding site [chemical binding]; other site
859657004025	Uncharacterized conserved protein [Function unknown]; Region: COG4273
859657004026	SCP-2 sterol transfer family; Region: SCP2; cl01225
859657004027	putative protease; Provisional; Region: PRK15447
859657004028	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
859657004029	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
859657004030	Peptidase family U32; Region: Peptidase_U32; pfam01136
859657004031	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
859657004032	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657004033	DNA-binding site [nucleotide binding]; DNA binding site
859657004034	UTRA domain; Region: UTRA; pfam07702
859657004035	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
859657004036	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
859657004037	Walker A/P-loop; other site
859657004038	ATP binding site [chemical binding]; other site
859657004039	Q-loop/lid; other site
859657004040	ABC transporter signature motif; other site
859657004041	Walker B; other site
859657004042	D-loop; other site
859657004043	H-loop/switch region; other site
859657004044	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
859657004045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657004046	putative PBP binding loops; other site
859657004047	ABC-ATPase subunit interface; other site
859657004048	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
859657004049	NMT1-like family; Region: NMT1_2; pfam13379
859657004050	Protein of unknown function, DUF488; Region: DUF488; cl01246
859657004051	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
859657004052	putative hydrophobic ligand binding site [chemical binding]; other site
859657004053	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657004054	putative DNA binding site [nucleotide binding]; other site
859657004055	putative Zn2+ binding site [ion binding]; other site
859657004056	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657004057	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657004058	DNA binding residues [nucleotide binding]
859657004059	dimerization interface [polypeptide binding]; other site
859657004060	Predicted membrane protein [Function unknown]; Region: COG4125
859657004061	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
859657004062	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
859657004063	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657004064	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657004065	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
859657004066	dimerization interface [polypeptide binding]; other site
859657004067	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
859657004068	homotrimer interaction site [polypeptide binding]; other site
859657004069	putative active site [active]
859657004070	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
859657004071	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
859657004072	tetramer interface [polypeptide binding]; other site
859657004073	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657004074	catalytic residue [active]
859657004075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
859657004076	YheO-like PAS domain; Region: PAS_6; pfam08348
859657004077	HTH domain; Region: HTH_22; pfam13309
859657004078	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859657004079	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
859657004080	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859657004081	Zn2+ binding site [ion binding]; other site
859657004082	Mg2+ binding site [ion binding]; other site
859657004083	HEXXH motif domain; Region: mod_HExxH; TIGR04267
859657004084	radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269
859657004085	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657004086	FeS/SAM binding site; other site
859657004087	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
859657004088	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859657004089	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657004090	Evidence 4 : Homologs of previously reported genes of unknown function
859657004091	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657004092	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859657004093	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657004094	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
859657004095	Evidence 7 : Gene remnant; Product type pe : putative enzyme
859657004096	Evidence 7 : Gene remnant; Product type pe : putative enzyme
859657004097	Evidence 7 : Gene remnant
859657004098	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
859657004099	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
859657004100	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657004101	short chain dehydrogenase; Validated; Region: PRK06182
859657004102	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
859657004103	NADP binding site [chemical binding]; other site
859657004104	active site
859657004105	steroid binding site; other site
859657004106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
859657004107	Evidence 7 : Gene remnant
859657004108	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
859657004109	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
859657004110	Evidence 7 : Gene remnant; Product type e : enzyme
859657004111	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
859657004112	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859657004113	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
859657004114	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859657004115	active site
859657004116	HIGH motif; other site
859657004117	nucleotide binding site [chemical binding]; other site
859657004118	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859657004119	active site
859657004120	KMSKS motif; other site
859657004121	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
859657004122	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
859657004123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657004124	putative substrate translocation pore; other site
859657004125	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
859657004126	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
859657004127	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
859657004128	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
859657004129	AAA domain; Region: AAA_18; pfam13238
859657004130	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
859657004131	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
859657004132	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859657004133	inhibitor-cofactor binding pocket; inhibition site
859657004134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657004135	catalytic residue [active]
859657004136	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
859657004137	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
859657004138	active site
859657004139	iron coordination sites [ion binding]; other site
859657004140	substrate binding pocket [chemical binding]; other site
859657004141	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
859657004142	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657004143	NAD(P) binding site [chemical binding]; other site
859657004144	active site
859657004145	cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586
859657004146	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
859657004147	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
859657004148	classical (c) SDRs; Region: SDR_c; cd05233
859657004149	NAD(P) binding site [chemical binding]; other site
859657004150	active site
859657004151	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
859657004152	Evidence 7 : Gene remnant
859657004153	ParB-like nuclease domain; Region: ParBc; pfam02195
859657004154	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
859657004155	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
859657004156	hypothetical protein; Validated; Region: PRK07078
859657004157	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
859657004158	AAA domain; Region: AAA_24; pfam13479
859657004159	AAA domain; Region: AAA_24; pfam13479
859657004160	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859657004161	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
859657004162	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859657004163	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859657004164	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
859657004165	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859657004166	AAA domain; Region: AAA_28; pfam13521
859657004167	Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655
859657004168	phosphoglycolate phosphatase; Provisional; Region: PRK13222
859657004169	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859657004170	motif II; other site
859657004171	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
859657004172	putative transposase OrfB; Reviewed; Region: PHA02517
859657004173	HTH-like domain; Region: HTH_21; pfam13276
859657004174	Integrase core domain; Region: rve; pfam00665
859657004175	Integrase core domain; Region: rve_3; pfam13683
859657004176	Transposase; Region: HTH_Tnp_1; pfam01527
859657004177	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator
859657004178	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
859657004179	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
859657004180	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
859657004181	Sulfate transporter family; Region: Sulfate_transp; pfam00916
859657004182	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
859657004183	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
859657004184	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
859657004185	Predicted integral membrane protein [Function unknown]; Region: COG0392
859657004186	Uncharacterized conserved protein [Function unknown]; Region: COG2898
859657004187	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
859657004188	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657004189	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657004190	metal binding site [ion binding]; metal-binding site
859657004191	active site
859657004192	I-site; other site
859657004193	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
859657004194	Immunoglobulin domain; Region: Ig; cl11960
859657004195	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
859657004196	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
859657004197	Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172
859657004198	PLD-like domain; Region: PLDc_2; pfam13091
859657004199	putative active site [active]
859657004200	catalytic site [active]
859657004201	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
859657004202	PLD-like domain; Region: PLDc_2; pfam13091
859657004203	putative active site [active]
859657004204	catalytic site [active]
859657004205	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
859657004206	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
859657004207	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
859657004208	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
859657004209	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
859657004210	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
859657004211	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
859657004212	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
859657004213	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
859657004214	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
859657004215	haemagglutination activity domain; Region: Haemagg_act; pfam05860
859657004216	Evidence 4 : Homologs of previously reported genes of unknown function
859657004217	haemagglutination activity domain; Region: Haemagg_act; pfam05860
859657004218	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
859657004219	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
859657004220	Part of AAA domain; Region: AAA_19; pfam13245
859657004221	Family description; Region: UvrD_C_2; pfam13538
859657004222	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
859657004223	putative active site [active]
859657004224	putative metal-binding site [ion binding]; other site
859657004225	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
859657004226	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
859657004227	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
859657004228	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
859657004229	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
859657004230	protein binding site [polypeptide binding]; other site
859657004231	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
859657004232	protein binding site [polypeptide binding]; other site
859657004233	sensor protein QseC; Provisional; Region: PRK10337
859657004234	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657004235	dimer interface [polypeptide binding]; other site
859657004236	phosphorylation site [posttranslational modification]
859657004237	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657004238	ATP binding site [chemical binding]; other site
859657004239	Mg2+ binding site [ion binding]; other site
859657004240	G-X-G motif; other site
859657004241	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657004242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004243	active site
859657004244	phosphorylation site [posttranslational modification]
859657004245	intermolecular recognition site; other site
859657004246	dimerization interface [polypeptide binding]; other site
859657004247	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657004248	DNA binding site [nucleotide binding]
859657004249	NolX protein; Region: NolX; pfam05819
859657004250	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
859657004251	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
859657004252	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
859657004253	putative active site [active]
859657004254	glucokinase; Provisional; Region: glk; PRK00292
859657004255	glucokinase, proteobacterial type; Region: glk; TIGR00749
859657004256	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
859657004257	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
859657004258	putative active site [active]
859657004259	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
859657004260	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
859657004261	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
859657004262	phosphogluconate dehydratase; Validated; Region: PRK09054
859657004263	6-phosphogluconate dehydratase; Region: edd; TIGR01196
859657004264	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859657004265	Ligand Binding Site [chemical binding]; other site
859657004266	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
859657004267	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
859657004268	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
859657004269	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
859657004270	Cytochrome c; Region: Cytochrom_C; cl11414
859657004271	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
859657004272	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
859657004273	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
859657004274	Subunit I/III interface [polypeptide binding]; other site
859657004275	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864
859657004276	Subunit I/III interface [polypeptide binding]; other site
859657004277	Predicted small integral membrane protein [Function unknown]; Region: COG5605
859657004278	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
859657004279	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657004280	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657004281	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657004282	dimerization interface [polypeptide binding]; other site
859657004283	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
859657004284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657004285	putative substrate translocation pore; other site
859657004286	Uncharacterized conserved protein [Function unknown]; Region: COG5476
859657004287	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
859657004288	MlrC C-terminus; Region: MlrC_C; pfam07171
859657004289	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657004290	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657004291	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
859657004292	dimerization interface [polypeptide binding]; other site
859657004293	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859657004294	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657004295	substrate binding pocket [chemical binding]; other site
859657004296	membrane-bound complex binding site; other site
859657004297	hinge residues; other site
859657004298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657004299	dimer interface [polypeptide binding]; other site
859657004300	conserved gate region; other site
859657004301	putative PBP binding loops; other site
859657004302	ABC-ATPase subunit interface; other site
859657004303	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859657004304	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657004305	dimer interface [polypeptide binding]; other site
859657004306	conserved gate region; other site
859657004307	putative PBP binding loops; other site
859657004308	ABC-ATPase subunit interface; other site
859657004309	agmatinase; Region: agmatinase; TIGR01230
859657004310	Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589
859657004311	oligomer interface [polypeptide binding]; other site
859657004312	active site
859657004313	Mn binding site [ion binding]; other site
859657004314	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657004315	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657004316	DNA binding residues [nucleotide binding]
859657004317	dimerization interface [polypeptide binding]; other site
859657004318	Evidence 4 : Homologs of previously reported genes of unknown function
859657004319	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
859657004320	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
859657004321	tetramer interface [polypeptide binding]; other site
859657004322	heme binding pocket [chemical binding]; other site
859657004323	hypothetical protein; Provisional; Region: PRK05939
859657004324	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859657004325	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859657004326	catalytic residue [active]
859657004327	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
859657004328	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
859657004329	aldehyde dehydrogenase family 7 member; Region: PLN02315
859657004330	tetrameric interface [polypeptide binding]; other site
859657004331	NAD binding site [chemical binding]; other site
859657004332	catalytic residues [active]
859657004333	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657004334	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
859657004335	dimerization interface [polypeptide binding]; other site
859657004336	ligand binding site [chemical binding]; other site
859657004337	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
859657004338	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657004339	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657004340	dimerization interface [polypeptide binding]; other site
859657004341	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657004342	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657004343	eyelet of channel; other site
859657004344	trimer interface [polypeptide binding]; other site
859657004345	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
859657004346	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657004347	putative substrate translocation pore; other site
859657004348	Tannase and feruloyl esterase; Region: Tannase; pfam07519
859657004349	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859657004350	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657004351	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
859657004352	E3 interaction surface; other site
859657004353	lipoyl attachment site [posttranslational modification]; other site
859657004354	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657004355	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859657004356	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859657004357	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657004358	non-specific DNA binding site [nucleotide binding]; other site
859657004359	salt bridge; other site
859657004360	sequence-specific DNA binding site [nucleotide binding]; other site
859657004361	Cupin domain; Region: Cupin_2; pfam07883
859657004362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657004363	metabolite-proton symporter; Region: 2A0106; TIGR00883
859657004364	putative substrate translocation pore; other site
859657004365	amidase; Provisional; Region: PRK07486
859657004366	Amidase; Region: Amidase; cl11426
859657004367	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
859657004368	homotrimer interaction site [polypeptide binding]; other site
859657004369	putative active site [active]
859657004370	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
859657004371	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859657004372	hydroxyglutarate oxidase; Provisional; Region: PRK11728
859657004373	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
859657004374	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
859657004375	active site
859657004376	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
859657004377	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
859657004378	active site
859657004379	metal binding site [ion binding]; metal-binding site
859657004380	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
859657004381	ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906
859657004382	succinic semialdehyde dehydrogenase; Region: PLN02278
859657004383	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
859657004384	tetramerization interface [polypeptide binding]; other site
859657004385	NAD(P) binding site [chemical binding]; other site
859657004386	catalytic residues [active]
859657004387	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
859657004388	tartrate dehydrogenase; Region: TTC; TIGR02089
859657004389	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
859657004390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657004391	D-galactonate transporter; Region: 2A0114; TIGR00893
859657004392	putative substrate translocation pore; other site
859657004393	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
859657004394	galactarate dehydratase; Region: galactar-dH20; TIGR03248
859657004395	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
859657004396	Transcriptional regulators [Transcription]; Region: PurR; COG1609
859657004397	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859657004398	DNA binding site [nucleotide binding]
859657004399	domain linker motif; other site
859657004400	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
859657004401	putative dimerization interface [polypeptide binding]; other site
859657004402	putative ligand binding site [chemical binding]; other site
859657004403	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
859657004404	ParB-like nuclease domain; Region: ParB; smart00470
859657004405	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
859657004406	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
859657004407	Active Sites [active]
859657004408	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
859657004409	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
859657004410	Haemagglutinin; Region: HIM; pfam05662
859657004411	Haemagglutinin; Region: HIM; pfam05662
859657004412	YadA-like C-terminal region; Region: YadA; pfam03895
859657004413	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657004414	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004415	active site
859657004416	phosphorylation site [posttranslational modification]
859657004417	intermolecular recognition site; other site
859657004418	dimerization interface [polypeptide binding]; other site
859657004419	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657004420	DNA binding residues [nucleotide binding]
859657004421	dimerization interface [polypeptide binding]; other site
859657004422	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657004423	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657004424	dimer interface [polypeptide binding]; other site
859657004425	phosphorylation site [posttranslational modification]
859657004426	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657004427	ATP binding site [chemical binding]; other site
859657004428	Mg2+ binding site [ion binding]; other site
859657004429	G-X-G motif; other site
859657004430	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859657004431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004432	active site
859657004433	phosphorylation site [posttranslational modification]
859657004434	intermolecular recognition site; other site
859657004435	dimerization interface [polypeptide binding]; other site
859657004436	Hpt domain; Region: Hpt; pfam01627
859657004437	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859657004438	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657004439	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
859657004440	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
859657004441	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859657004442	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657004443	non-specific DNA binding site [nucleotide binding]; other site
859657004444	salt bridge; other site
859657004445	sequence-specific DNA binding site [nucleotide binding]; other site
859657004446	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845
859657004447	cyanate hydratase; Validated; Region: PRK02866
859657004448	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
859657004449	oligomer interface [polypeptide binding]; other site
859657004450	active site
859657004451	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
859657004452	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
859657004453	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
859657004454	putative ligand binding site [chemical binding]; other site
859657004455	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
859657004456	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
859657004457	Walker A/P-loop; other site
859657004458	ATP binding site [chemical binding]; other site
859657004459	Q-loop/lid; other site
859657004460	ABC transporter signature motif; other site
859657004461	Walker B; other site
859657004462	D-loop; other site
859657004463	H-loop/switch region; other site
859657004464	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
859657004465	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
859657004466	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
859657004467	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859657004468	TM-ABC transporter signature motif; other site
859657004469	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
859657004470	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657004471	NAD(P) binding site [chemical binding]; other site
859657004472	active site
859657004473	Transcriptional regulators [Transcription]; Region: PurR; COG1609
859657004474	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859657004475	DNA binding site [nucleotide binding]
859657004476	domain linker motif; other site
859657004477	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
859657004478	putative dimerization interface [polypeptide binding]; other site
859657004479	putative ligand binding site [chemical binding]; other site
859657004480	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859657004481	EamA-like transporter family; Region: EamA; pfam00892
859657004482	Cupin domain; Region: Cupin_2; cl17218
859657004483	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
859657004484	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657004485	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657004486	short chain dehydrogenase; Validated; Region: PRK08264
859657004487	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657004488	NAD(P) binding site [chemical binding]; other site
859657004489	active site
859657004490	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859657004491	MarR family; Region: MarR_2; pfam12802
859657004492	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
859657004493	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
859657004494	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
859657004495	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859657004496	MarR family; Region: MarR; pfam01047
859657004497	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
859657004498	active site 1 [active]
859657004499	dimer interface [polypeptide binding]; other site
859657004500	hexamer interface [polypeptide binding]; other site
859657004501	active site 2 [active]
859657004502	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
859657004503	Response regulator receiver domain; Region: Response_reg; pfam00072
859657004504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004505	active site
859657004506	phosphorylation site [posttranslational modification]
859657004507	intermolecular recognition site; other site
859657004508	dimerization interface [polypeptide binding]; other site
859657004509	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657004510	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657004511	metal binding site [ion binding]; metal-binding site
859657004512	active site
859657004513	I-site; other site
859657004514	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
859657004515	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004516	phosphorylation site [posttranslational modification]
859657004517	intermolecular recognition site; other site
859657004518	CheB methylesterase; Region: CheB_methylest; pfam01339
859657004519	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
859657004520	putative binding surface; other site
859657004521	active site
859657004522	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
859657004523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657004524	ATP binding site [chemical binding]; other site
859657004525	Mg2+ binding site [ion binding]; other site
859657004526	G-X-G motif; other site
859657004527	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
859657004528	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859657004529	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004530	active site
859657004531	phosphorylation site [posttranslational modification]
859657004532	intermolecular recognition site; other site
859657004533	dimerization interface [polypeptide binding]; other site
859657004534	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
859657004535	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
859657004536	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657004537	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
859657004538	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859657004539	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657004540	dimerization interface [polypeptide binding]; other site
859657004541	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
859657004542	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657004543	dimer interface [polypeptide binding]; other site
859657004544	putative CheW interface [polypeptide binding]; other site
859657004545	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
859657004546	Putative zinc-finger; Region: zf-HC2; pfam13490
859657004547	RNA polymerase sigma factor; Provisional; Region: PRK12533
859657004548	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657004549	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
859657004550	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859657004551	active site
859657004552	metal binding site [ion binding]; metal-binding site
859657004553	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
859657004554	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
859657004555	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
859657004556	dinuclear metal binding motif [ion binding]; other site
859657004557	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
859657004558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657004559	S-adenosylmethionine binding site [chemical binding]; other site
859657004560	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
859657004561	active site
859657004562	acyl carrier protein; Provisional; Region: acpP; PRK00982
859657004563	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
859657004564	putative di-iron ligands [ion binding]; other site
859657004565	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
859657004566	Patatin-like phospholipase; Region: Patatin; pfam01734
859657004567	active site
859657004568	nucleophile elbow; other site
859657004569	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
859657004570	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657004571	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
859657004572	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
859657004573	G1 box; other site
859657004574	putative GEF interaction site [polypeptide binding]; other site
859657004575	GTP/Mg2+ binding site [chemical binding]; other site
859657004576	Switch I region; other site
859657004577	G2 box; other site
859657004578	G3 box; other site
859657004579	Switch II region; other site
859657004580	G4 box; other site
859657004581	G5 box; other site
859657004582	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
859657004583	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
859657004584	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
859657004585	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
859657004586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004587	active site
859657004588	phosphorylation site [posttranslational modification]
859657004589	intermolecular recognition site; other site
859657004590	dimerization interface [polypeptide binding]; other site
859657004591	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657004592	Walker A motif; other site
859657004593	ATP binding site [chemical binding]; other site
859657004594	Walker B motif; other site
859657004595	arginine finger; other site
859657004596	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859657004597	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657004598	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
859657004599	Walker A motif; other site
859657004600	ATP binding site [chemical binding]; other site
859657004601	Walker B motif; other site
859657004602	arginine finger; other site
859657004603	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859657004604	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
859657004605	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
859657004606	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
859657004607	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
859657004608	Predicted deacetylase [General function prediction only]; Region: COG3233
859657004609	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
859657004610	putative active site [active]
859657004611	putative Zn binding site [ion binding]; other site
859657004612	PAP2 superfamily; Region: PAP2; pfam01569
859657004613	active site
859657004614	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657004615	PAS fold; Region: PAS_3; pfam08447
859657004616	putative active site [active]
859657004617	heme pocket [chemical binding]; other site
859657004618	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657004619	PAS domain; Region: PAS_9; pfam13426
859657004620	putative active site [active]
859657004621	heme pocket [chemical binding]; other site
859657004622	PAS domain; Region: PAS; smart00091
859657004623	PAS fold; Region: PAS_4; pfam08448
859657004624	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657004625	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657004626	dimer interface [polypeptide binding]; other site
859657004627	phosphorylation site [posttranslational modification]
859657004628	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657004629	ATP binding site [chemical binding]; other site
859657004630	Mg2+ binding site [ion binding]; other site
859657004631	G-X-G motif; other site
859657004632	Response regulator receiver domain; Region: Response_reg; pfam00072
859657004633	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004634	active site
859657004635	phosphorylation site [posttranslational modification]
859657004636	intermolecular recognition site; other site
859657004637	dimerization interface [polypeptide binding]; other site
859657004638	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
859657004639	active site
859657004640	Int/Topo IB signature motif; other site
859657004641	DNA binding site [nucleotide binding]
859657004642	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
859657004643	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
859657004644	DnaA N-terminal domain; Region: DnaA_N; pfam11638
859657004645	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
859657004646	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657004647	Walker A motif; other site
859657004648	ATP binding site [chemical binding]; other site
859657004649	Walker B motif; other site
859657004650	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
859657004651	arginine finger; other site
859657004652	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
859657004653	DnaA box-binding interface [nucleotide binding]; other site
859657004654	DNA polymerase III subunit beta; Validated; Region: PRK05643
859657004655	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
859657004656	putative DNA binding surface [nucleotide binding]; other site
859657004657	dimer interface [polypeptide binding]; other site
859657004658	beta-clamp/clamp loader binding surface; other site
859657004659	beta-clamp/translesion DNA polymerase binding surface; other site
859657004660	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
859657004661	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657004662	ATP binding site [chemical binding]; other site
859657004663	Mg2+ binding site [ion binding]; other site
859657004664	G-X-G motif; other site
859657004665	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
859657004666	anchoring element; other site
859657004667	dimer interface [polypeptide binding]; other site
859657004668	ATP binding site [chemical binding]; other site
859657004669	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
859657004670	active site
859657004671	putative metal-binding site [ion binding]; other site
859657004672	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
859657004673	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
859657004674	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
859657004675	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
859657004676	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657004677	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657004678	DNA binding residues [nucleotide binding]
859657004679	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657004680	ATP binding site [chemical binding]; other site
859657004681	Mg2+ binding site [ion binding]; other site
859657004682	G-X-G motif; other site
859657004683	Z1 domain; Region: Z1; pfam10593
859657004684	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
859657004685	AIPR protein; Region: AIPR; pfam10592
859657004686	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pcp : putative cell process
859657004687	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
859657004688	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
859657004689	cofactor binding site; other site
859657004690	DNA binding site [nucleotide binding]
859657004691	substrate interaction site [chemical binding]; other site
859657004692	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
859657004693	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859657004694	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859657004695	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859657004696	Uncharacterized conserved protein [Function unknown]; Region: COG5435
859657004697	PAAR motif; Region: PAAR_motif; pfam05488
859657004698	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
859657004699	HD domain; Region: HD_4; pfam13328
859657004700	Evidence 4 : Homologs of previously reported genes of unknown function
859657004701	Restriction endonuclease; Region: Mrr_cat; pfam04471
859657004702	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
859657004703	Predicted membrane protein [Function unknown]; Region: COG3781
859657004704	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859657004705	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657004706	dimer interface [polypeptide binding]; other site
859657004707	putative CheW interface [polypeptide binding]; other site
859657004708	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859657004709	Transcriptional regulator [Transcription]; Region: IclR; COG1414
859657004710	Bacterial transcriptional regulator; Region: IclR; pfam01614
859657004711	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657004712	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859657004713	substrate binding pocket [chemical binding]; other site
859657004714	membrane-bound complex binding site; other site
859657004715	hinge residues; other site
859657004716	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859657004717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657004718	dimer interface [polypeptide binding]; other site
859657004719	conserved gate region; other site
859657004720	putative PBP binding loops; other site
859657004721	ABC-ATPase subunit interface; other site
859657004722	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
859657004723	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859657004724	Walker A/P-loop; other site
859657004725	ATP binding site [chemical binding]; other site
859657004726	Q-loop/lid; other site
859657004727	ABC transporter signature motif; other site
859657004728	Walker B; other site
859657004729	D-loop; other site
859657004730	H-loop/switch region; other site
859657004731	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
859657004732	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
859657004733	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657004734	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
859657004735	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
859657004736	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859657004737	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859657004738	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859657004739	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859657004740	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657004741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004742	active site
859657004743	phosphorylation site [posttranslational modification]
859657004744	intermolecular recognition site; other site
859657004745	dimerization interface [polypeptide binding]; other site
859657004746	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657004747	DNA binding site [nucleotide binding]
859657004748	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657004749	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657004750	dimer interface [polypeptide binding]; other site
859657004751	phosphorylation site [posttranslational modification]
859657004752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657004753	ATP binding site [chemical binding]; other site
859657004754	Mg2+ binding site [ion binding]; other site
859657004755	G-X-G motif; other site
859657004756	CAAX protease self-immunity; Region: Abi; pfam02517
859657004757	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
859657004758	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657004759	putative substrate translocation pore; other site
859657004760	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
859657004761	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
859657004762	heme-binding site [chemical binding]; other site
859657004763	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
859657004764	FAD binding pocket [chemical binding]; other site
859657004765	FAD binding motif [chemical binding]; other site
859657004766	phosphate binding motif [ion binding]; other site
859657004767	beta-alpha-beta structure motif; other site
859657004768	NAD binding pocket [chemical binding]; other site
859657004769	Heme binding  pocket [chemical binding]; other site
859657004770	Transcriptional regulator; Region: Rrf2; cl17282
859657004771	Rrf2 family protein; Region: rrf2_super; TIGR00738
859657004772	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
859657004773	Methyltransferase domain; Region: Methyltransf_26; pfam13659
859657004774	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
859657004775	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
859657004776	ATP binding site [chemical binding]; other site
859657004777	putative Mg++ binding site [ion binding]; other site
859657004778	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
859657004779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657004780	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657004781	dimer interface [polypeptide binding]; other site
859657004782	phosphorylation site [posttranslational modification]
859657004783	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657004784	ATP binding site [chemical binding]; other site
859657004785	Mg2+ binding site [ion binding]; other site
859657004786	G-X-G motif; other site
859657004787	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
859657004788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004789	active site
859657004790	phosphorylation site [posttranslational modification]
859657004791	intermolecular recognition site; other site
859657004792	dimerization interface [polypeptide binding]; other site
859657004793	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657004794	DNA binding site [nucleotide binding]
859657004795	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
859657004796	NMT1/THI5 like; Region: NMT1; pfam09084
859657004797	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657004798	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657004799	trimer interface [polypeptide binding]; other site
859657004800	eyelet of channel; other site
859657004801	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657004802	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657004803	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657004804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004805	active site
859657004806	phosphorylation site [posttranslational modification]
859657004807	intermolecular recognition site; other site
859657004808	dimerization interface [polypeptide binding]; other site
859657004809	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657004810	DNA binding residues [nucleotide binding]
859657004811	dimerization interface [polypeptide binding]; other site
859657004812	Response regulator receiver domain; Region: Response_reg; pfam00072
859657004813	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004814	active site
859657004815	phosphorylation site [posttranslational modification]
859657004816	intermolecular recognition site; other site
859657004817	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657004818	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
859657004819	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
859657004820	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
859657004821	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
859657004822	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
859657004823	Ligand Binding Site [chemical binding]; other site
859657004824	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
859657004825	GAF domain; Region: GAF_3; pfam13492
859657004826	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657004827	dimer interface [polypeptide binding]; other site
859657004828	phosphorylation site [posttranslational modification]
859657004829	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657004830	ATP binding site [chemical binding]; other site
859657004831	Mg2+ binding site [ion binding]; other site
859657004832	G-X-G motif; other site
859657004833	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
859657004834	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
859657004835	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
859657004836	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
859657004837	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
859657004838	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
859657004839	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657004840	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657004841	DNA binding residues [nucleotide binding]
859657004842	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
859657004843	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
859657004844	Walker A/P-loop; other site
859657004845	ATP binding site [chemical binding]; other site
859657004846	Q-loop/lid; other site
859657004847	ABC transporter signature motif; other site
859657004848	Walker B; other site
859657004849	D-loop; other site
859657004850	H-loop/switch region; other site
859657004851	Uncharacterized conserved protein [Function unknown]; Region: COG4754
859657004852	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
859657004853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657004854	dimer interface [polypeptide binding]; other site
859657004855	conserved gate region; other site
859657004856	putative PBP binding loops; other site
859657004857	ABC-ATPase subunit interface; other site
859657004858	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657004859	dimer interface [polypeptide binding]; other site
859657004860	conserved gate region; other site
859657004861	putative PBP binding loops; other site
859657004862	ABC-ATPase subunit interface; other site
859657004863	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
859657004864	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
859657004865	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
859657004866	CoA-transferase family III; Region: CoA_transf_3; pfam02515
859657004867	cell division topological specificity factor MinE; Provisional; Region: PRK13989
859657004868	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
859657004869	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
859657004870	Switch I; other site
859657004871	Switch II; other site
859657004872	septum formation inhibitor; Reviewed; Region: PRK01973
859657004873	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
859657004874	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
859657004875	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
859657004876	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
859657004877	active site
859657004878	metal binding site [ion binding]; metal-binding site
859657004879	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
859657004880	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
859657004881	Sel1-like repeats; Region: SEL1; smart00671
859657004882	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
859657004883	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
859657004884	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
859657004885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4322
859657004886	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
859657004887	IHF dimer interface [polypeptide binding]; other site
859657004888	IHF - DNA interface [nucleotide binding]; other site
859657004889	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657004890	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
859657004891	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657004892	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657004893	dimer interface [polypeptide binding]; other site
859657004894	phosphorylation site [posttranslational modification]
859657004895	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657004896	ATP binding site [chemical binding]; other site
859657004897	Mg2+ binding site [ion binding]; other site
859657004898	G-X-G motif; other site
859657004899	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657004900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657004901	active site
859657004902	phosphorylation site [posttranslational modification]
859657004903	intermolecular recognition site; other site
859657004904	dimerization interface [polypeptide binding]; other site
859657004905	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657004906	DNA binding site [nucleotide binding]
859657004907	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
859657004908	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
859657004909	aromatic arch; other site
859657004910	DCoH dimer interaction site [polypeptide binding]; other site
859657004911	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
859657004912	DCoH tetramer interaction site [polypeptide binding]; other site
859657004913	substrate binding site [chemical binding]; other site
859657004914	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
859657004915	cofactor binding site; other site
859657004916	metal binding site [ion binding]; metal-binding site
859657004917	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859657004918	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
859657004919	AsnC family; Region: AsnC_trans_reg; pfam01037
859657004920	Predicted membrane protein [Function unknown]; Region: COG3714
859657004921	ornithine cyclodeaminase; Validated; Region: PRK07340
859657004922	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
859657004923	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
859657004924	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
859657004925	metal-binding site [ion binding]
859657004926	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
859657004927	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
859657004928	metal-binding site [ion binding]
859657004929	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
859657004930	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859657004931	motif II; other site
859657004932	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
859657004933	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
859657004934	DNA binding residues [nucleotide binding]
859657004935	dimer interface [polypeptide binding]; other site
859657004936	copper binding site [ion binding]; other site
859657004937	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
859657004938	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
859657004939	choline dehydrogenase; Validated; Region: PRK02106
859657004940	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
859657004941	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859657004942	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859657004943	Walker A/P-loop; other site
859657004944	ATP binding site [chemical binding]; other site
859657004945	Q-loop/lid; other site
859657004946	ABC transporter signature motif; other site
859657004947	Walker B; other site
859657004948	D-loop; other site
859657004949	H-loop/switch region; other site
859657004950	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859657004951	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859657004952	Walker A/P-loop; other site
859657004953	ATP binding site [chemical binding]; other site
859657004954	Q-loop/lid; other site
859657004955	ABC transporter signature motif; other site
859657004956	Walker B; other site
859657004957	D-loop; other site
859657004958	H-loop/switch region; other site
859657004959	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859657004960	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
859657004961	putative ligand binding site [chemical binding]; other site
859657004962	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859657004963	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859657004964	TM-ABC transporter signature motif; other site
859657004965	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859657004966	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859657004967	TM-ABC transporter signature motif; other site
859657004968	hypothetical protein; Provisional; Region: PRK10621
859657004969	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
859657004970	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859657004971	Zn2+ binding site [ion binding]; other site
859657004972	Mg2+ binding site [ion binding]; other site
859657004973	atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229
859657004974	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
859657004975	putative NAD(P) binding site [chemical binding]; other site
859657004976	putative active site [active]
859657004977	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657004978	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657004979	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657004980	dimerization interface [polypeptide binding]; other site
859657004981	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
859657004982	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657004983	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657004984	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
859657004985	putative effector binding pocket; other site
859657004986	putative dimerization interface [polypeptide binding]; other site
859657004987	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
859657004988	putative NAD(P) binding site [chemical binding]; other site
859657004989	homodimer interface [polypeptide binding]; other site
859657004990	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657004991	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
859657004992	putative ligand binding site [chemical binding]; other site
859657004993	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
859657004994	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
859657004995	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
859657004996	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
859657004997	Putative methyltransferase; Region: Methyltransf_16; pfam10294
859657004998	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657004999	S-adenosylmethionine binding site [chemical binding]; other site
859657005000	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
859657005001	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
859657005002	P-loop; other site
859657005003	Magnesium ion binding site [ion binding]; other site
859657005004	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
859657005005	Magnesium ion binding site [ion binding]; other site
859657005006	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
859657005007	ParB-like nuclease domain; Region: ParB; smart00470
859657005008	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
859657005009	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
859657005010	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
859657005011	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
859657005012	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
859657005013	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
859657005014	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
859657005015	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
859657005016	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
859657005017	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
859657005018	beta subunit interaction interface [polypeptide binding]; other site
859657005019	Walker A motif; other site
859657005020	ATP binding site [chemical binding]; other site
859657005021	Walker B motif; other site
859657005022	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
859657005023	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
859657005024	core domain interface [polypeptide binding]; other site
859657005025	delta subunit interface [polypeptide binding]; other site
859657005026	epsilon subunit interface [polypeptide binding]; other site
859657005027	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
859657005028	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
859657005029	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
859657005030	alpha subunit interaction interface [polypeptide binding]; other site
859657005031	Walker A motif; other site
859657005032	ATP binding site [chemical binding]; other site
859657005033	Walker B motif; other site
859657005034	inhibitor binding site; inhibition site
859657005035	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
859657005036	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
859657005037	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
859657005038	gamma subunit interface [polypeptide binding]; other site
859657005039	epsilon subunit interface [polypeptide binding]; other site
859657005040	LBP interface [polypeptide binding]; other site
859657005041	FecR protein; Region: FecR; pfam04773
859657005042	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
859657005043	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
859657005044	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
859657005045	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
859657005046	Protein of unknown function (DUF3562); Region: DUF3562; pfam12085
859657005047	PBP superfamily domain; Region: PBP_like_2; cl17296
859657005048	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
859657005049	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
859657005050	Cache domain; Region: Cache_1; pfam02743
859657005051	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657005052	dimerization interface [polypeptide binding]; other site
859657005053	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
859657005054	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657005055	dimer interface [polypeptide binding]; other site
859657005056	putative CheW interface [polypeptide binding]; other site
859657005057	Uncharacterized conserved protein [Function unknown]; Region: COG3791
859657005058	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
859657005059	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
859657005060	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
859657005061	substrate binding site [chemical binding]; other site
859657005062	active site
859657005063	primosome assembly protein PriA; Validated; Region: PRK05580
859657005064	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859657005065	ATP binding site [chemical binding]; other site
859657005066	putative Mg++ binding site [ion binding]; other site
859657005067	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
859657005068	Predicted transcriptional regulator [Transcription]; Region: COG3905
859657005069	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
859657005070	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
859657005071	Glutamate binding site [chemical binding]; other site
859657005072	NAD binding site [chemical binding]; other site
859657005073	catalytic residues [active]
859657005074	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
859657005075	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657005076	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
859657005077	dimerization interface [polypeptide binding]; other site
859657005078	ligand binding site [chemical binding]; other site
859657005079	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
859657005080	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
859657005081	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
859657005082	Coenzyme A binding pocket [chemical binding]; other site
859657005083	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
859657005084	Predicted membrane protein [Function unknown]; Region: COG1297
859657005085	putative oligopeptide transporter, OPT family; Region: TIGR00733
859657005086	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
859657005087	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
859657005088	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
859657005089	glycine dehydrogenase; Provisional; Region: PRK05367
859657005090	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
859657005091	tetramer interface [polypeptide binding]; other site
859657005092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657005093	catalytic residue [active]
859657005094	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
859657005095	tetramer interface [polypeptide binding]; other site
859657005096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657005097	catalytic residue [active]
859657005098	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
859657005099	lipoyl attachment site [posttranslational modification]; other site
859657005100	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
859657005101	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
859657005102	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
859657005103	Acyltransferase family; Region: Acyl_transf_3; pfam01757
859657005104	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
859657005105	Part of AAA domain; Region: AAA_19; pfam13245
859657005106	Family description; Region: UvrD_C_2; pfam13538
859657005107	Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472
859657005108	Inclusion body protein; Region: PixA; pfam12306
859657005109	Inclusion body protein; Region: PixA; pfam12306
859657005110	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
859657005111	Autoinducer binding domain; Region: Autoind_bind; pfam03472
859657005112	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657005113	DNA binding residues [nucleotide binding]
859657005114	dimerization interface [polypeptide binding]; other site
859657005115	N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916
859657005116	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657005117	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
859657005118	putative ligand binding site [chemical binding]; other site
859657005119	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
859657005120	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657005121	FeS/SAM binding site; other site
859657005122	HemN C-terminal domain; Region: HemN_C; pfam06969
859657005123	tartronate semialdehyde reductase; Provisional; Region: PRK15059
859657005124	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
859657005125	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
859657005126	glyoxylate carboligase; Provisional; Region: PRK11269
859657005127	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
859657005128	PYR/PP interface [polypeptide binding]; other site
859657005129	dimer interface [polypeptide binding]; other site
859657005130	TPP binding site [chemical binding]; other site
859657005131	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
859657005132	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
859657005133	TPP-binding site [chemical binding]; other site
859657005134	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657005135	transcriptional activator TtdR; Provisional; Region: PRK09801
859657005136	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657005137	putative effector binding pocket; other site
859657005138	dimerization interface [polypeptide binding]; other site
859657005139	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
859657005140	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657005141	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859657005142	non-specific DNA binding site [nucleotide binding]; other site
859657005143	salt bridge; other site
859657005144	sequence-specific DNA binding site [nucleotide binding]; other site
859657005145	Uncharacterized conserved protein [Function unknown]; Region: COG1739
859657005146	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
859657005147	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
859657005148	Transcriptional regulators [Transcription]; Region: GntR; COG1802
859657005149	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657005150	DNA-binding site [nucleotide binding]; DNA binding site
859657005151	FCD domain; Region: FCD; pfam07729
859657005152	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
859657005153	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
859657005154	allantoicase; Provisional; Region: PRK13257
859657005155	Allantoicase repeat; Region: Allantoicase; pfam03561
859657005156	Allantoicase repeat; Region: Allantoicase; pfam03561
859657005157	ureidoglycolate hydrolase; Provisional; Region: PRK03606
859657005158	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
859657005159	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
859657005160	M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697
859657005161	putative metal binding site [ion binding]; other site
859657005162	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
859657005163	ArsC family; Region: ArsC; pfam03960
859657005164	catalytic residues [active]
859657005165	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
859657005166	active site
859657005167	substrate binding site [chemical binding]; other site
859657005168	catalytic site [active]
859657005169	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
859657005170	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
859657005171	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
859657005172	Predicted methyltransferases [General function prediction only]; Region: COG0313
859657005173	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
859657005174	putative SAM binding site [chemical binding]; other site
859657005175	putative homodimer interface [polypeptide binding]; other site
859657005176	hypothetical protein; Provisional; Region: PRK14673
859657005177	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
859657005178	BON domain; Region: BON; pfam04972
859657005179	bacterial OsmY and nodulation domain; Region: BON; smart00749
859657005180	Cytochrome c; Region: Cytochrom_C; cl11414
859657005181	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
859657005182	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
859657005183	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
859657005184	EamA-like transporter family; Region: EamA; pfam00892
859657005185	Cytochrome c551/c552 [Energy production and conversion]; Region: COG4654
859657005186	Predicted secreted protein [Function unknown]; Region: COG5501
859657005187	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
859657005188	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
859657005189	Uncharacterized conserved protein [Function unknown]; Region: COG1416
859657005190	Cytochrome c; Region: Cytochrom_C; cl11414
859657005191	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
859657005192	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859657005193	catalytic residues [active]
859657005194	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
859657005195	active site
859657005196	metal binding site [ion binding]; metal-binding site
859657005197	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
859657005198	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
859657005199	Beta protein; Region: Beta_protein; pfam14350
859657005200	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
859657005201	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
859657005202	catalytic residues [active]
859657005203	catalytic nucleophile [active]
859657005204	Presynaptic Site I dimer interface [polypeptide binding]; other site
859657005205	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
859657005206	Synaptic Flat tetramer interface [polypeptide binding]; other site
859657005207	Synaptic Site I dimer interface [polypeptide binding]; other site
859657005208	DNA binding site [nucleotide binding]
859657005209	Recombinase; Region: Recombinase; pfam07508
859657005210	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
859657005211	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
859657005212	Helix-turn-helix domain; Region: HTH_17; cl17695
859657005213	Helix-turn-helix domain; Region: HTH_17; pfam12728
859657005214	AAA domain; Region: AAA_24; pfam13479
859657005215	hypothetical protein; Validated; Region: PRK07078
859657005216	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
859657005217	active site
859657005218	metal binding site [ion binding]; metal-binding site
859657005219	interdomain interaction site; other site
859657005220	D5 N terminal like; Region: D5_N; smart00885
859657005221	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
859657005222	active site
859657005223	putative DNA-binding cleft [nucleotide binding]; other site
859657005224	dimer interface [polypeptide binding]; other site
859657005225	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
859657005226	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
859657005227	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
859657005228	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
859657005229	putative active site [active]
859657005230	putative NTP binding site [chemical binding]; other site
859657005231	putative nucleic acid binding site [nucleotide binding]; other site
859657005232	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
859657005233	ParB-like nuclease domain; Region: ParBc; pfam02195
859657005234	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
859657005235	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
859657005236	DNA methylase; Region: N6_N4_Mtase; pfam01555
859657005237	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
859657005238	ParB-like nuclease domain; Region: ParBc; pfam02195
859657005239	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
859657005240	DNA methylase; Region: N6_N4_Mtase; pfam01555
859657005241	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
859657005242	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
859657005243	Evidence 4 : Homologs of previously reported genes of unknown function
859657005244	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
859657005245	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
859657005246	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
859657005247	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
859657005248	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
859657005249	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
859657005250	tandem repeat interface [polypeptide binding]; other site
859657005251	oligomer interface [polypeptide binding]; other site
859657005252	active site residues [active]
859657005253	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
859657005254	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
859657005255	H-NS histone family; Region: Histone_HNS; pfam00816
859657005256	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
859657005257	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
859657005258	Active Sites [active]
859657005259	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657005260	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
859657005261	oligomeric interface; other site
859657005262	putative active site [active]
859657005263	homodimer interface [polypeptide binding]; other site
859657005264	prevent-host-death family protein; Region: phd_fam; TIGR01552
859657005265	Phage-related minor tail protein [Function unknown]; Region: COG5281
859657005266	tape measure domain; Region: tape_meas_nterm; TIGR02675
859657005267	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
859657005268	catalytic residues [active]
859657005269	Protein of unknown function (DUF1484); Region: DUF1484; pfam07363
859657005270	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2958
859657005271	haemagglutination activity domain; Region: Haemagg_act; pfam05860
859657005272	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
859657005273	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859657005274	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859657005275	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859657005276	Evidence 4 : Homologs of previously reported genes of unknown function
859657005277	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
859657005278	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
859657005279	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
859657005280	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
859657005281	DNA primase domain-containing protein; Region: PHA02415
859657005282	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859657005283	RHS Repeat; Region: RHS_repeat; pfam05593
859657005284	RHS Repeat; Region: RHS_repeat; pfam05593
859657005285	RHS Repeat; Region: RHS_repeat; cl11982
859657005286	RHS Repeat; Region: RHS_repeat; pfam05593
859657005287	RHS Repeat; Region: RHS_repeat; pfam05593
859657005288	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859657005289	RHS Repeat; Region: RHS_repeat; pfam05593
859657005290	RHS Repeat; Region: RHS_repeat; pfam05593
859657005291	RHS Repeat; Region: RHS_repeat; pfam05593
859657005292	RHS Repeat; Region: RHS_repeat; cl11982
859657005293	RHS Repeat; Region: RHS_repeat; cl11982
859657005294	RHS Repeat; Region: RHS_repeat; pfam05593
859657005295	RHS Repeat; Region: RHS_repeat; pfam05593
859657005296	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pcp : putative cell process
859657005297	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
859657005298	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657005299	S-adenosylmethionine binding site [chemical binding]; other site
859657005300	Predicted flavoproteins [General function prediction only]; Region: COG2081
859657005301	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
859657005302	Methyltransferase domain; Region: Methyltransf_32; pfam13679
859657005303	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
859657005304	DNA-binding interface [nucleotide binding]; DNA binding site
859657005305	HTH-like domain; Region: HTH_21; pfam13276
859657005306	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
859657005307	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4922
859657005308	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657005309	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657005310	Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778
859657005311	FMN binding site [chemical binding]; other site
859657005312	dimer interface [polypeptide binding]; other site
859657005313	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
859657005314	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657005315	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657005316	metal binding site [ion binding]; metal-binding site
859657005317	active site
859657005318	I-site; other site
859657005319	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657005320	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657005321	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
859657005322	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
859657005323	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
859657005324	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
859657005325	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
859657005326	putative acyl-acceptor binding pocket; other site
859657005327	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
859657005328	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
859657005329	Interdomain contacts; other site
859657005330	Cytokine receptor motif; other site
859657005331	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
859657005332	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
859657005333	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
859657005334	Cytochrome c; Region: Cytochrom_C; pfam00034
859657005335	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859657005336	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657005337	non-specific DNA binding site [nucleotide binding]; other site
859657005338	salt bridge; other site
859657005339	sequence-specific DNA binding site [nucleotide binding]; other site
859657005340	Evidence 4 : Homologs of previously reported genes of unknown function
859657005341	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657005342	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
859657005343	putative ligand binding site [chemical binding]; other site
859657005344	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
859657005345	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657005346	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657005347	metal binding site [ion binding]; metal-binding site
859657005348	active site
859657005349	I-site; other site
859657005350	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
859657005351	active site
859657005352	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
859657005353	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
859657005354	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
859657005355	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657005356	dimerization interface [polypeptide binding]; other site
859657005357	DNA binding residues [nucleotide binding]
859657005358	MarR family; Region: MarR_2; cl17246
859657005359	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859657005360	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
859657005361	classical (c) SDRs; Region: SDR_c; cd05233
859657005362	NAD(P) binding site [chemical binding]; other site
859657005363	active site
859657005364	Uncharacterized conserved protein [Function unknown]; Region: COG3868
859657005365	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
859657005366	C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922
859657005367	putative active site [active]
859657005368	HAMP domain; Region: HAMP; pfam00672
859657005369	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657005370	dimer interface [polypeptide binding]; other site
859657005371	putative CheW interface [polypeptide binding]; other site
859657005372	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
859657005373	dinuclear metal binding motif [ion binding]; other site
859657005374	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
859657005375	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
859657005376	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
859657005377	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859657005378	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657005379	non-specific DNA binding site [nucleotide binding]; other site
859657005380	salt bridge; other site
859657005381	sequence-specific DNA binding site [nucleotide binding]; other site
859657005382	Cupin domain; Region: Cupin_2; cl17218
859657005383	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
859657005384	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
859657005385	putative ligand binding site [chemical binding]; other site
859657005386	putative NAD binding site [chemical binding]; other site
859657005387	catalytic site [active]
859657005388	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
859657005389	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
859657005390	NAD binding site [chemical binding]; other site
859657005391	substrate binding site [chemical binding]; other site
859657005392	catalytic Zn binding site [ion binding]; other site
859657005393	tetramer interface [polypeptide binding]; other site
859657005394	structural Zn binding site [ion binding]; other site
859657005395	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1378052; Product type pr : putative regulator
859657005396	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
859657005397	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1378052; Product type pr : putative regulator
859657005398	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
859657005399	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859657005400	NAD(P) binding site [chemical binding]; other site
859657005401	catalytic residues [active]
859657005402	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
859657005403	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
859657005404	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
859657005405	exonuclease I; Provisional; Region: sbcB; PRK11779
859657005406	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
859657005407	active site
859657005408	catalytic site [active]
859657005409	substrate binding site [chemical binding]; other site
859657005410	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
859657005411	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
859657005412	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
859657005413	dimer interface [polypeptide binding]; other site
859657005414	PYR/PP interface [polypeptide binding]; other site
859657005415	TPP binding site [chemical binding]; other site
859657005416	substrate binding site [chemical binding]; other site
859657005417	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
859657005418	TPP-binding site; other site
859657005419	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
859657005420	Evidence 4 : Homologs of previously reported genes of unknown function
859657005421	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
859657005422	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657005423	DNA-binding site [nucleotide binding]; DNA binding site
859657005424	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657005425	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657005426	homodimer interface [polypeptide binding]; other site
859657005427	catalytic residue [active]
859657005428	type II secretion system protein F; Region: GspF; TIGR02120
859657005429	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859657005430	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859657005431	type II secretion system protein E; Region: type_II_gspE; TIGR02533
859657005432	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
859657005433	Walker A motif; other site
859657005434	ATP binding site [chemical binding]; other site
859657005435	Walker B motif; other site
859657005436	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859657005437	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859657005438	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859657005439	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
859657005440	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859657005441	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
859657005442	Type II secretory pathway, component PulM [Intracellular trafficking and secretion]; Region: PulM; COG3149
859657005443	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
859657005444	GspL periplasmic domain; Region: GspL_C; pfam12693
859657005445	Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156
859657005446	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
859657005447	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
859657005448	Type II transport protein GspH; Region: GspH; pfam12019
859657005449	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
859657005450	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
859657005451	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
859657005452	EF-hand domain pair; Region: EF_hand_5; pfam13499
859657005453	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
859657005454	EF-hand domain pair; Region: EF_hand_5; pfam13499
859657005455	Ca2+ binding site [ion binding]; other site
859657005456	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
859657005457	EF-hand domain pair; Region: EF_hand_5; pfam13499
859657005458	Ca2+ binding site [ion binding]; other site
859657005459	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
859657005460	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
859657005461	dimer interface [polypeptide binding]; other site
859657005462	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
859657005463	active site
859657005464	Fe binding site [ion binding]; other site
859657005465	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859657005466	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657005467	putative DNA binding site [nucleotide binding]; other site
859657005468	putative Zn2+ binding site [ion binding]; other site
859657005469	AsnC family; Region: AsnC_trans_reg; pfam01037
859657005470	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
859657005471	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
859657005472	putative active site [active]
859657005473	putative catalytic triad [active]
859657005474	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
859657005475	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
859657005476	SnoaL-like domain; Region: SnoaL_3; pfam13474
859657005477	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
859657005478	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657005479	Coenzyme A binding pocket [chemical binding]; other site
859657005480	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
859657005481	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859657005482	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
859657005483	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
859657005484	TrkA-N domain; Region: TrkA_N; pfam02254
859657005485	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
859657005486	Protein of unknown function; Region: DUF3658; pfam12395
859657005487	glutamate carboxypeptidase; Reviewed; Region: PRK06133
859657005488	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
859657005489	metal binding site [ion binding]; metal-binding site
859657005490	dimer interface [polypeptide binding]; other site
859657005491	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657005492	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657005493	trimer interface [polypeptide binding]; other site
859657005494	eyelet of channel; other site
859657005495	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
859657005496	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
859657005497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657005498	active site
859657005499	phosphorylation site [posttranslational modification]
859657005500	intermolecular recognition site; other site
859657005501	dimerization interface [polypeptide binding]; other site
859657005502	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657005503	DNA binding site [nucleotide binding]
859657005504	High potential iron-sulfur protein; Region: HIPIP; pfam01355
859657005505	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
859657005506	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859657005507	Bacterial transcriptional regulator; Region: IclR; pfam01614
859657005508	benzoate transport; Region: 2A0115; TIGR00895
859657005509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657005510	putative substrate translocation pore; other site
859657005511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657005512	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
859657005513	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
859657005514	dimer interface [polypeptide binding]; other site
859657005515	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
859657005516	active site
859657005517	Fe binding site [ion binding]; other site
859657005518	Protein of unknown function (DUF1484); Region: DUF1484; pfam07363
859657005519	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
859657005520	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657005521	Predicted membrane protein [Function unknown]; Region: COG4541
859657005522	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
859657005523	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859657005524	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657005525	putative DNA binding site [nucleotide binding]; other site
859657005526	putative Zn2+ binding site [ion binding]; other site
859657005527	AsnC family; Region: AsnC_trans_reg; pfam01037
859657005528	Evidence 4 : Homologs of previously reported genes of unknown function
859657005529	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
859657005530	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
859657005531	Evidence 4 : Homologs of previously reported genes of unknown function
859657005532	Evidence 4 : Homologs of previously reported genes of unknown function
859657005533	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657005534	PAS domain; Region: PAS_9; pfam13426
859657005535	putative active site [active]
859657005536	heme pocket [chemical binding]; other site
859657005537	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657005538	dimer interface [polypeptide binding]; other site
859657005539	phosphorylation site [posttranslational modification]
859657005540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657005541	ATP binding site [chemical binding]; other site
859657005542	Mg2+ binding site [ion binding]; other site
859657005543	G-X-G motif; other site
859657005544	Response regulator receiver domain; Region: Response_reg; pfam00072
859657005545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657005546	active site
859657005547	phosphorylation site [posttranslational modification]
859657005548	intermolecular recognition site; other site
859657005549	dimerization interface [polypeptide binding]; other site
859657005550	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657005551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657005552	active site
859657005553	phosphorylation site [posttranslational modification]
859657005554	intermolecular recognition site; other site
859657005555	dimerization interface [polypeptide binding]; other site
859657005556	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657005557	DNA binding residues [nucleotide binding]
859657005558	dimerization interface [polypeptide binding]; other site
859657005559	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
859657005560	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
859657005561	glutathione s-transferase; Provisional; Region: PTZ00057
859657005562	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
859657005563	GSH binding site (G-site) [chemical binding]; other site
859657005564	C-terminal domain interface [polypeptide binding]; other site
859657005565	dimer interface [polypeptide binding]; other site
859657005566	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
859657005567	N-terminal domain interface [polypeptide binding]; other site
859657005568	dimer interface [polypeptide binding]; other site
859657005569	substrate binding pocket (H-site) [chemical binding]; other site
859657005570	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657005571	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859657005572	putative substrate translocation pore; other site
859657005573	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
859657005574	Mechanosensitive ion channel; Region: MS_channel; pfam00924
859657005575	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
859657005576	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
859657005577	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
859657005578	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
859657005579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657005580	active site
859657005581	phosphorylation site [posttranslational modification]
859657005582	intermolecular recognition site; other site
859657005583	dimerization interface [polypeptide binding]; other site
859657005584	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657005585	DNA binding site [nucleotide binding]
859657005586	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
859657005587	dimerization interface [polypeptide binding]; other site
859657005588	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657005589	dimer interface [polypeptide binding]; other site
859657005590	phosphorylation site [posttranslational modification]
859657005591	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657005592	ATP binding site [chemical binding]; other site
859657005593	Mg2+ binding site [ion binding]; other site
859657005594	G-X-G motif; other site
859657005595	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
859657005596	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
859657005597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657005598	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657005599	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657005600	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
859657005601	putative ligand binding site [chemical binding]; other site
859657005602	citrate-proton symporter; Provisional; Region: PRK15075
859657005603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657005604	putative substrate translocation pore; other site
859657005605	citrate-proton symporter; Provisional; Region: PRK15075
859657005606	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657005607	putative substrate translocation pore; other site
859657005608	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
859657005609	dimerization interface [polypeptide binding]; other site
859657005610	putative active cleft [active]
859657005611	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
859657005612	Protein of unknown function (DUF1415); Region: DUF1415; cl01301
859657005613	glycerol kinase; Provisional; Region: glpK; PRK00047
859657005614	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
859657005615	N- and C-terminal domain interface [polypeptide binding]; other site
859657005616	active site
859657005617	MgATP binding site [chemical binding]; other site
859657005618	catalytic site [active]
859657005619	metal binding site [ion binding]; metal-binding site
859657005620	glycerol binding site [chemical binding]; other site
859657005621	homotetramer interface [polypeptide binding]; other site
859657005622	homodimer interface [polypeptide binding]; other site
859657005623	FBP binding site [chemical binding]; other site
859657005624	protein IIAGlc interface [polypeptide binding]; other site
859657005625	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
859657005626	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
859657005627	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
859657005628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657005629	dimer interface [polypeptide binding]; other site
859657005630	conserved gate region; other site
859657005631	putative PBP binding loops; other site
859657005632	ABC-ATPase subunit interface; other site
859657005633	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
859657005634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657005635	dimer interface [polypeptide binding]; other site
859657005636	conserved gate region; other site
859657005637	putative PBP binding loops; other site
859657005638	ABC-ATPase subunit interface; other site
859657005639	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
859657005640	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
859657005641	Walker A/P-loop; other site
859657005642	ATP binding site [chemical binding]; other site
859657005643	Q-loop/lid; other site
859657005644	ABC transporter signature motif; other site
859657005645	Walker B; other site
859657005646	D-loop; other site
859657005647	H-loop/switch region; other site
859657005648	TOBE domain; Region: TOBE_2; pfam08402
859657005649	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
859657005650	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
859657005651	Walker A/P-loop; other site
859657005652	ATP binding site [chemical binding]; other site
859657005653	Q-loop/lid; other site
859657005654	ABC transporter signature motif; other site
859657005655	Walker B; other site
859657005656	D-loop; other site
859657005657	H-loop/switch region; other site
859657005658	TOBE domain; Region: TOBE_2; pfam08402
859657005659	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
859657005660	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
859657005661	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
859657005662	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
859657005663	Uncharacterized conserved protein [Function unknown]; Region: COG5607
859657005664	elongation factor Tu; Reviewed; Region: PRK00049
859657005665	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
859657005666	G1 box; other site
859657005667	GEF interaction site [polypeptide binding]; other site
859657005668	GTP/Mg2+ binding site [chemical binding]; other site
859657005669	Switch I region; other site
859657005670	G2 box; other site
859657005671	G3 box; other site
859657005672	Switch II region; other site
859657005673	G4 box; other site
859657005674	G5 box; other site
859657005675	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
859657005676	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
859657005677	Antibiotic Binding Site [chemical binding]; other site
859657005678	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
859657005679	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
859657005680	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
859657005681	putative homodimer interface [polypeptide binding]; other site
859657005682	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
859657005683	heterodimer interface [polypeptide binding]; other site
859657005684	homodimer interface [polypeptide binding]; other site
859657005685	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
859657005686	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
859657005687	23S rRNA interface [nucleotide binding]; other site
859657005688	L7/L12 interface [polypeptide binding]; other site
859657005689	putative thiostrepton binding site; other site
859657005690	L25 interface [polypeptide binding]; other site
859657005691	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
859657005692	mRNA/rRNA interface [nucleotide binding]; other site
859657005693	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
859657005694	23S rRNA interface [nucleotide binding]; other site
859657005695	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
859657005696	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
859657005697	core dimer interface [polypeptide binding]; other site
859657005698	peripheral dimer interface [polypeptide binding]; other site
859657005699	L10 interface [polypeptide binding]; other site
859657005700	L11 interface [polypeptide binding]; other site
859657005701	putative EF-Tu interaction site [polypeptide binding]; other site
859657005702	putative EF-G interaction site [polypeptide binding]; other site
859657005703	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
859657005704	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
859657005705	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
859657005706	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
859657005707	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
859657005708	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
859657005709	RPB3 interaction site [polypeptide binding]; other site
859657005710	RPB1 interaction site [polypeptide binding]; other site
859657005711	RPB11 interaction site [polypeptide binding]; other site
859657005712	RPB10 interaction site [polypeptide binding]; other site
859657005713	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
859657005714	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
859657005715	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
859657005716	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
859657005717	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
859657005718	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
859657005719	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
859657005720	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
859657005721	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
859657005722	DNA binding site [nucleotide binding]
859657005723	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
859657005724	Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; pfam09909
859657005725	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234
859657005726	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
859657005727	MG2 domain; Region: A2M_N; pfam01835
859657005728	Alpha-2-macroglobulin family; Region: A2M; pfam00207
859657005729	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
859657005730	Predicted secreted protein [Function unknown]; Region: COG5445
859657005731	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
859657005732	Predicted secreted protein [Function unknown]; Region: COG5445
859657005733	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
859657005734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
859657005735	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
859657005736	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
859657005737	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
859657005738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657005739	S-adenosylmethionine binding site [chemical binding]; other site
859657005740	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
859657005741	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859657005742	ATP binding site [chemical binding]; other site
859657005743	putative Mg++ binding site [ion binding]; other site
859657005744	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859657005745	nucleotide binding region [chemical binding]; other site
859657005746	ATP-binding site [chemical binding]; other site
859657005747	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
859657005748	HRDC domain; Region: HRDC; pfam00570
859657005749	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
859657005750	S17 interaction site [polypeptide binding]; other site
859657005751	S8 interaction site; other site
859657005752	16S rRNA interaction site [nucleotide binding]; other site
859657005753	streptomycin interaction site [chemical binding]; other site
859657005754	23S rRNA interaction site [nucleotide binding]; other site
859657005755	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
859657005756	30S ribosomal protein S7; Validated; Region: PRK05302
859657005757	elongation factor G; Reviewed; Region: PRK00007
859657005758	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
859657005759	G1 box; other site
859657005760	putative GEF interaction site [polypeptide binding]; other site
859657005761	GTP/Mg2+ binding site [chemical binding]; other site
859657005762	Switch I region; other site
859657005763	G2 box; other site
859657005764	G3 box; other site
859657005765	Switch II region; other site
859657005766	G4 box; other site
859657005767	G5 box; other site
859657005768	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
859657005769	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
859657005770	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
859657005771	elongation factor Tu; Reviewed; Region: PRK00049
859657005772	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
859657005773	G1 box; other site
859657005774	GEF interaction site [polypeptide binding]; other site
859657005775	GTP/Mg2+ binding site [chemical binding]; other site
859657005776	Switch I region; other site
859657005777	G2 box; other site
859657005778	G3 box; other site
859657005779	Switch II region; other site
859657005780	G4 box; other site
859657005781	G5 box; other site
859657005782	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
859657005783	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
859657005784	Antibiotic Binding Site [chemical binding]; other site
859657005785	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
859657005786	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
859657005787	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
859657005788	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
859657005789	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
859657005790	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
859657005791	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
859657005792	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
859657005793	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
859657005794	putative translocon binding site; other site
859657005795	protein-rRNA interface [nucleotide binding]; other site
859657005796	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
859657005797	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
859657005798	G-X-X-G motif; other site
859657005799	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
859657005800	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
859657005801	23S rRNA interface [nucleotide binding]; other site
859657005802	5S rRNA interface [nucleotide binding]; other site
859657005803	putative antibiotic binding site [chemical binding]; other site
859657005804	L25 interface [polypeptide binding]; other site
859657005805	L27 interface [polypeptide binding]; other site
859657005806	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
859657005807	23S rRNA interface [nucleotide binding]; other site
859657005808	putative translocon interaction site; other site
859657005809	signal recognition particle (SRP54) interaction site; other site
859657005810	L23 interface [polypeptide binding]; other site
859657005811	trigger factor interaction site; other site
859657005812	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
859657005813	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
859657005814	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
859657005815	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
859657005816	RNA binding site [nucleotide binding]; other site
859657005817	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
859657005818	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
859657005819	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
859657005820	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
859657005821	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
859657005822	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
859657005823	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
859657005824	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
859657005825	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
859657005826	5S rRNA interface [nucleotide binding]; other site
859657005827	23S rRNA interface [nucleotide binding]; other site
859657005828	L5 interface [polypeptide binding]; other site
859657005829	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
859657005830	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
859657005831	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
859657005832	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
859657005833	23S rRNA binding site [nucleotide binding]; other site
859657005834	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
859657005835	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
859657005836	SecY translocase; Region: SecY; pfam00344
859657005837	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
859657005838	rRNA binding site [nucleotide binding]; other site
859657005839	predicted 30S ribosome binding site; other site
859657005840	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
859657005841	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
859657005842	30S ribosomal protein S13; Region: bact_S13; TIGR03631
859657005843	30S ribosomal protein S11; Validated; Region: PRK05309
859657005844	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
859657005845	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
859657005846	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859657005847	RNA binding surface [nucleotide binding]; other site
859657005848	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
859657005849	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
859657005850	alphaNTD homodimer interface [polypeptide binding]; other site
859657005851	alphaNTD - beta interaction site [polypeptide binding]; other site
859657005852	alphaNTD - beta' interaction site [polypeptide binding]; other site
859657005853	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
859657005854	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
859657005855	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
859657005856	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
859657005857	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
859657005858	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
859657005859	DsbD alpha interface [polypeptide binding]; other site
859657005860	catalytic residues [active]
859657005861	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
859657005862	dimer interface [polypeptide binding]; other site
859657005863	active site
859657005864	aspartate-rich active site metal binding site; other site
859657005865	allosteric magnesium binding site [ion binding]; other site
859657005866	Schiff base residues; other site
859657005867	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
859657005868	G1 box; other site
859657005869	GTP/Mg2+ binding site [chemical binding]; other site
859657005870	Switch I region; other site
859657005871	G2 box; other site
859657005872	G3 box; other site
859657005873	Switch II region; other site
859657005874	G4 box; other site
859657005875	G5 box; other site
859657005876	Cytochrome c553 [Energy production and conversion]; Region: COG2863
859657005877	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
859657005878	Cytochrome c; Region: Cytochrom_C; cl11414
859657005879	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
859657005880	ResB-like family; Region: ResB; pfam05140
859657005881	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
859657005882	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
859657005883	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
859657005884	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
859657005885	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657005886	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657005887	DNA binding residues [nucleotide binding]
859657005888	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
859657005889	TMAO/DMSO reductase; Reviewed; Region: PRK05363
859657005890	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
859657005891	Moco binding site; other site
859657005892	metal coordination site [ion binding]; other site
859657005893	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
859657005894	diaminopimelate decarboxylase; Region: lysA; TIGR01048
859657005895	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
859657005896	active site
859657005897	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859657005898	substrate binding site [chemical binding]; other site
859657005899	catalytic residues [active]
859657005900	dimer interface [polypeptide binding]; other site
859657005901	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
859657005902	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
859657005903	putative iron binding site [ion binding]; other site
859657005904	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
859657005905	Transglycosylase; Region: Transgly; pfam00912
859657005906	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
859657005907	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
859657005908	Cell division protein FtsA; Region: FtsA; cl17206
859657005909	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
859657005910	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
859657005911	Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167
859657005912	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
859657005913	Pilus assembly protein, PilP; Region: PilP; pfam04351
859657005914	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
859657005915	AMIN domain; Region: AMIN; pfam11741
859657005916	Secretin and TonB N terminus short domain; Region: STN; smart00965
859657005917	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859657005918	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859657005919	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
859657005920	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
859657005921	ADP binding site [chemical binding]; other site
859657005922	magnesium binding site [ion binding]; other site
859657005923	putative shikimate binding site; other site
859657005924	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
859657005925	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
859657005926	active site
859657005927	dimer interface [polypeptide binding]; other site
859657005928	metal binding site [ion binding]; metal-binding site
859657005929	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
859657005930	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859657005931	Zn2+ binding site [ion binding]; other site
859657005932	Mg2+ binding site [ion binding]; other site
859657005933	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
859657005934	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
859657005935	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
859657005936	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
859657005937	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
859657005938	active site
859657005939	dimer interface [polypeptide binding]; other site
859657005940	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
859657005941	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
859657005942	active site
859657005943	FMN binding site [chemical binding]; other site
859657005944	substrate binding site [chemical binding]; other site
859657005945	3Fe-4S cluster binding site [ion binding]; other site
859657005946	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
859657005947	domain interface; other site
859657005948	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
859657005949	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859657005950	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859657005951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
859657005952	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
859657005953	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
859657005954	Walker A/P-loop; other site
859657005955	ATP binding site [chemical binding]; other site
859657005956	Q-loop/lid; other site
859657005957	ABC transporter signature motif; other site
859657005958	Walker B; other site
859657005959	D-loop; other site
859657005960	H-loop/switch region; other site
859657005961	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
859657005962	Permease; Region: Permease; pfam02405
859657005963	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
859657005964	mce related protein; Region: MCE; pfam02470
859657005965	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
859657005966	ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854
859657005967	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
859657005968	anti sigma factor interaction site; other site
859657005969	regulatory phosphorylation site [posttranslational modification]; other site
859657005970	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
859657005971	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
859657005972	Walker A/P-loop; other site
859657005973	ATP binding site [chemical binding]; other site
859657005974	Q-loop/lid; other site
859657005975	ABC transporter signature motif; other site
859657005976	Walker B; other site
859657005977	D-loop; other site
859657005978	H-loop/switch region; other site
859657005979	ABC-2 type transporter; Region: ABC2_membrane; cl17235
859657005980	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
859657005981	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
859657005982	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
859657005983	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
859657005984	hinge; other site
859657005985	active site
859657005986	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
859657005987	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
859657005988	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
859657005989	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
859657005990	NAD binding site [chemical binding]; other site
859657005991	dimerization interface [polypeptide binding]; other site
859657005992	product binding site; other site
859657005993	substrate binding site [chemical binding]; other site
859657005994	zinc binding site [ion binding]; other site
859657005995	catalytic residues [active]
859657005996	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
859657005997	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657005998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657005999	homodimer interface [polypeptide binding]; other site
859657006000	catalytic residue [active]
859657006001	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
859657006002	putative active site pocket [active]
859657006003	4-fold oligomerization interface [polypeptide binding]; other site
859657006004	metal binding residues [ion binding]; metal-binding site
859657006005	3-fold/trimer interface [polypeptide binding]; other site
859657006006	MarC family integral membrane protein; Region: MarC; cl00919
859657006007	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
859657006008	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
859657006009	putative active site [active]
859657006010	oxyanion strand; other site
859657006011	catalytic triad [active]
859657006012	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
859657006013	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
859657006014	catalytic residues [active]
859657006015	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
859657006016	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
859657006017	substrate binding site [chemical binding]; other site
859657006018	glutamase interaction surface [polypeptide binding]; other site
859657006019	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
859657006020	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
859657006021	metal binding site [ion binding]; metal-binding site
859657006022	Predicted membrane protein [Function unknown]; Region: COG3671
859657006023	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
859657006024	sec-independent translocase; Provisional; Region: tatB; PRK01919
859657006025	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
859657006026	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
859657006027	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
859657006028	Walker A/P-loop; other site
859657006029	ATP binding site [chemical binding]; other site
859657006030	Q-loop/lid; other site
859657006031	ABC transporter signature motif; other site
859657006032	Walker B; other site
859657006033	D-loop; other site
859657006034	H-loop/switch region; other site
859657006035	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
859657006036	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657006037	dimer interface [polypeptide binding]; other site
859657006038	conserved gate region; other site
859657006039	ABC-ATPase subunit interface; other site
859657006040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657006041	dimer interface [polypeptide binding]; other site
859657006042	conserved gate region; other site
859657006043	putative PBP binding loops; other site
859657006044	ABC-ATPase subunit interface; other site
859657006045	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
859657006046	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
859657006047	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
859657006048	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657006049	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657006050	dimer interface [polypeptide binding]; other site
859657006051	phosphorylation site [posttranslational modification]
859657006052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657006053	ATP binding site [chemical binding]; other site
859657006054	Mg2+ binding site [ion binding]; other site
859657006055	G-X-G motif; other site
859657006056	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
859657006057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657006058	active site
859657006059	phosphorylation site [posttranslational modification]
859657006060	intermolecular recognition site; other site
859657006061	dimerization interface [polypeptide binding]; other site
859657006062	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657006063	DNA binding site [nucleotide binding]
859657006064	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
859657006065	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
859657006066	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657006067	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657006068	trimer interface [polypeptide binding]; other site
859657006069	eyelet of channel; other site
859657006070	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
859657006071	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
859657006072	protein binding site [polypeptide binding]; other site
859657006073	Uncharacterized conserved protein [Function unknown]; Region: COG0327
859657006074	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
859657006075	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
859657006076	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
859657006077	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
859657006078	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
859657006079	[2Fe-2S] cluster binding site [ion binding]; other site
859657006080	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
859657006081	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
859657006082	Qi binding site; other site
859657006083	intrachain domain interface; other site
859657006084	interchain domain interface [polypeptide binding]; other site
859657006085	heme bH binding site [chemical binding]; other site
859657006086	heme bL binding site [chemical binding]; other site
859657006087	Qo binding site; other site
859657006088	interchain domain interface [polypeptide binding]; other site
859657006089	intrachain domain interface; other site
859657006090	Qi binding site; other site
859657006091	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
859657006092	Qo binding site; other site
859657006093	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
859657006094	Cytochrome c; Region: Cytochrom_C; cl11414
859657006095	stringent starvation protein A; Provisional; Region: sspA; PRK09481
859657006096	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
859657006097	C-terminal domain interface [polypeptide binding]; other site
859657006098	putative GSH binding site (G-site) [chemical binding]; other site
859657006099	dimer interface [polypeptide binding]; other site
859657006100	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
859657006101	dimer interface [polypeptide binding]; other site
859657006102	N-terminal domain interface [polypeptide binding]; other site
859657006103	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
859657006104	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657006105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657006106	dimer interface [polypeptide binding]; other site
859657006107	phosphorylation site [posttranslational modification]
859657006108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657006109	ATP binding site [chemical binding]; other site
859657006110	Mg2+ binding site [ion binding]; other site
859657006111	G-X-G motif; other site
859657006112	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
859657006113	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859657006114	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
859657006115	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
859657006116	Secretin and TonB N terminus short domain; Region: STN; smart00965
859657006117	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
859657006118	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859657006119	N-terminal plug; other site
859657006120	ligand-binding site [chemical binding]; other site
859657006121	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
859657006122	FecR protein; Region: FecR; pfam04773
859657006123	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
859657006124	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657006125	DNA binding residues [nucleotide binding]
859657006126	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
859657006127	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
859657006128	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
859657006129	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
859657006130	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
859657006131	D-pathway; other site
859657006132	Putative ubiquinol binding site [chemical binding]; other site
859657006133	Low-spin heme (heme b) binding site [chemical binding]; other site
859657006134	Putative water exit pathway; other site
859657006135	Binuclear center (heme o3/CuB) [ion binding]; other site
859657006136	K-pathway; other site
859657006137	Putative proton exit pathway; other site
859657006138	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
859657006139	Subunit I/III interface [polypeptide binding]; other site
859657006140	Subunit III/IV interface [polypeptide binding]; other site
859657006141	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
859657006142	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
859657006143	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657006144	Walker A/P-loop; other site
859657006145	ATP binding site [chemical binding]; other site
859657006146	Q-loop/lid; other site
859657006147	ABC transporter signature motif; other site
859657006148	Walker B; other site
859657006149	D-loop; other site
859657006150	H-loop/switch region; other site
859657006151	ABC transporter; Region: ABC_tran_2; pfam12848
859657006152	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859657006153	Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369
859657006154	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
859657006155	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
859657006156	putative deacylase active site [active]
859657006157	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
859657006158	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
859657006159	Ligand binding site; other site
859657006160	DXD motif; other site
859657006161	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
859657006162	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
859657006163	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
859657006164	Flavoprotein; Region: Flavoprotein; pfam02441
859657006165	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
859657006166	putative GSH binding site [chemical binding]; other site
859657006167	catalytic residues [active]
859657006168	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
859657006169	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
859657006170	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
859657006171	putative active site [active]
859657006172	putative NTP binding site [chemical binding]; other site
859657006173	putative nucleic acid binding site [nucleotide binding]; other site
859657006174	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
859657006175	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
859657006176	active site
859657006177	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
859657006178	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657006179	S-adenosylmethionine binding site [chemical binding]; other site
859657006180	peptide chain release factor 1; Validated; Region: prfA; PRK00591
859657006181	This domain is found in peptide chain release factors; Region: PCRF; smart00937
859657006182	RF-1 domain; Region: RF-1; pfam00472
859657006183	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
859657006184	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
859657006185	tRNA; other site
859657006186	putative tRNA binding site [nucleotide binding]; other site
859657006187	putative NADP binding site [chemical binding]; other site
859657006188	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
859657006189	GTP-binding protein YchF; Reviewed; Region: PRK09601
859657006190	YchF GTPase; Region: YchF; cd01900
859657006191	G1 box; other site
859657006192	GTP/Mg2+ binding site [chemical binding]; other site
859657006193	Switch I region; other site
859657006194	G2 box; other site
859657006195	Switch II region; other site
859657006196	G3 box; other site
859657006197	G4 box; other site
859657006198	G5 box; other site
859657006199	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
859657006200	Flagellar protein FliT; Region: FliT; pfam05400
859657006201	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859657006202	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859657006203	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859657006204	catalytic residue [active]
859657006205	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608
859657006206	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
859657006207	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
859657006208	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
859657006209	dimerization domain [polypeptide binding]; other site
859657006210	dimer interface [polypeptide binding]; other site
859657006211	catalytic residues [active]
859657006212	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
859657006213	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
859657006214	NADP binding site [chemical binding]; other site
859657006215	dimer interface [polypeptide binding]; other site
859657006216	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
859657006217	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
859657006218	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
859657006219	protein binding site [polypeptide binding]; other site
859657006220	Predicted membrane protein [Function unknown]; Region: COG1289
859657006221	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
859657006222	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
859657006223	Evidence 4 : Homologs of previously reported genes of unknown function
859657006224	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
859657006225	ligand binding site [chemical binding]; other site
859657006226	active site
859657006227	UGI interface [polypeptide binding]; other site
859657006228	catalytic site [active]
859657006229	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
859657006230	putative active site [active]
859657006231	putative metal binding residues [ion binding]; other site
859657006232	signature motif; other site
859657006233	putative triphosphate binding site [ion binding]; other site
859657006234	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
859657006235	active site
859657006236	ribulose/triose binding site [chemical binding]; other site
859657006237	phosphate binding site [ion binding]; other site
859657006238	substrate (anthranilate) binding pocket [chemical binding]; other site
859657006239	product (indole) binding pocket [chemical binding]; other site
859657006240	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
859657006241	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
859657006242	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
859657006243	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
859657006244	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
859657006245	glutamine binding [chemical binding]; other site
859657006246	catalytic triad [active]
859657006247	anthranilate synthase component I; Provisional; Region: PRK13565
859657006248	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
859657006249	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
859657006250	phosphoglycolate phosphatase; Provisional; Region: PRK13222
859657006251	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859657006252	motif II; other site
859657006253	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
859657006254	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
859657006255	substrate binding site [chemical binding]; other site
859657006256	hexamer interface [polypeptide binding]; other site
859657006257	metal binding site [ion binding]; metal-binding site
859657006258	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
859657006259	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
859657006260	MltA specific insert domain; Region: MltA; smart00925
859657006261	3D domain; Region: 3D; pfam06725
859657006262	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657006263	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
859657006264	acyl-activating enzyme (AAE) consensus motif; other site
859657006265	AMP binding site [chemical binding]; other site
859657006266	active site
859657006267	CoA binding site [chemical binding]; other site
859657006268	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
859657006269	CoenzymeA binding site [chemical binding]; other site
859657006270	subunit interaction site [polypeptide binding]; other site
859657006271	PHB binding site; other site
859657006272	enoyl-CoA hydratase; Provisional; Region: PRK08140
859657006273	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657006274	substrate binding site [chemical binding]; other site
859657006275	oxyanion hole (OAH) forming residues; other site
859657006276	trimer interface [polypeptide binding]; other site
859657006277	enoyl-CoA hydratase; Provisional; Region: PRK05862
859657006278	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657006279	substrate binding site [chemical binding]; other site
859657006280	oxyanion hole (OAH) forming residues; other site
859657006281	trimer interface [polypeptide binding]; other site
859657006282	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
859657006283	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
859657006284	metal binding site [ion binding]; metal-binding site
859657006285	putative dimer interface [polypeptide binding]; other site
859657006286	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
859657006287	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
859657006288	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
859657006289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657006290	dimer interface [polypeptide binding]; other site
859657006291	conserved gate region; other site
859657006292	putative PBP binding loops; other site
859657006293	ABC-ATPase subunit interface; other site
859657006294	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
859657006295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657006296	dimer interface [polypeptide binding]; other site
859657006297	conserved gate region; other site
859657006298	putative PBP binding loops; other site
859657006299	ABC-ATPase subunit interface; other site
859657006300	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
859657006301	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859657006302	Walker A/P-loop; other site
859657006303	ATP binding site [chemical binding]; other site
859657006304	Q-loop/lid; other site
859657006305	ABC transporter signature motif; other site
859657006306	Walker B; other site
859657006307	D-loop; other site
859657006308	H-loop/switch region; other site
859657006309	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
859657006310	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
859657006311	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859657006312	Walker A/P-loop; other site
859657006313	ATP binding site [chemical binding]; other site
859657006314	Q-loop/lid; other site
859657006315	ABC transporter signature motif; other site
859657006316	Walker B; other site
859657006317	D-loop; other site
859657006318	H-loop/switch region; other site
859657006319	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
859657006320	acetylornithine deacetylase; Provisional; Region: PRK07522
859657006321	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
859657006322	metal binding site [ion binding]; metal-binding site
859657006323	putative dimer interface [polypeptide binding]; other site
859657006324	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657006325	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
859657006326	putative ligand binding site [chemical binding]; other site
859657006327	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
859657006328	active site
859657006329	P-loop; other site
859657006330	phosphorylation site [posttranslational modification]
859657006331	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
859657006332	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
859657006333	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
859657006334	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
859657006335	putative substrate binding site [chemical binding]; other site
859657006336	putative ATP binding site [chemical binding]; other site
859657006337	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
859657006338	active site
859657006339	phosphorylation site [posttranslational modification]
859657006340	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
859657006341	dimerization domain swap beta strand [polypeptide binding]; other site
859657006342	regulatory protein interface [polypeptide binding]; other site
859657006343	active site
859657006344	regulatory phosphorylation site [posttranslational modification]; other site
859657006345	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
859657006346	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
859657006347	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
859657006348	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
859657006349	Transcriptional regulators [Transcription]; Region: PurR; COG1609
859657006350	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859657006351	DNA binding site [nucleotide binding]
859657006352	domain linker motif; other site
859657006353	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280
859657006354	putative dimerization interface [polypeptide binding]; other site
859657006355	putative ligand binding site [chemical binding]; other site
859657006356	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
859657006357	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
859657006358	putative [4Fe-4S] binding site [ion binding]; other site
859657006359	putative molybdopterin cofactor binding site [chemical binding]; other site
859657006360	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
859657006361	putative molybdopterin cofactor binding site; other site
859657006362	Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720
859657006363	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
859657006364	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
859657006365	acyl-activating enzyme (AAE) consensus motif; other site
859657006366	putative AMP binding site [chemical binding]; other site
859657006367	putative active site [active]
859657006368	putative CoA binding site [chemical binding]; other site
859657006369	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657006370	metabolite-proton symporter; Region: 2A0106; TIGR00883
859657006371	putative substrate translocation pore; other site
859657006372	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657006373	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657006374	trimer interface [polypeptide binding]; other site
859657006375	eyelet of channel; other site
859657006376	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
859657006377	diiron binding motif [ion binding]; other site
859657006378	cell division protein MraZ; Reviewed; Region: PRK00326
859657006379	MraZ protein; Region: MraZ; pfam02381
859657006380	MraZ protein; Region: MraZ; pfam02381
859657006381	MraW methylase family; Region: Methyltransf_5; cl17771
859657006382	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
859657006383	Cell division protein FtsL; Region: FtsL; cl11433
859657006384	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
859657006385	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
859657006386	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
859657006387	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
859657006388	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
859657006389	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
859657006390	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
859657006391	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
859657006392	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
859657006393	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
859657006394	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
859657006395	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
859657006396	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
859657006397	Mg++ binding site [ion binding]; other site
859657006398	putative catalytic motif [active]
859657006399	putative substrate binding site [chemical binding]; other site
859657006400	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
859657006401	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
859657006402	cell division protein FtsW; Region: ftsW; TIGR02614
859657006403	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
859657006404	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
859657006405	active site
859657006406	homodimer interface [polypeptide binding]; other site
859657006407	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
859657006408	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
859657006409	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
859657006410	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
859657006411	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
859657006412	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
859657006413	ATP-grasp domain; Region: ATP-grasp_4; cl17255
859657006414	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
859657006415	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
859657006416	Cell division protein FtsQ; Region: FtsQ; pfam03799
859657006417	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
859657006418	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
859657006419	nucleotide binding site [chemical binding]; other site
859657006420	Cell division protein FtsA; Region: FtsA; pfam14450
859657006421	cell division protein FtsZ; Validated; Region: PRK09330
859657006422	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
859657006423	nucleotide binding site [chemical binding]; other site
859657006424	SulA interaction site; other site
859657006425	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
859657006426	catalytic triad [active]
859657006427	dimer interface [polypeptide binding]; other site
859657006428	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
859657006429	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
859657006430	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
859657006431	Peptidase family M23; Region: Peptidase_M23; pfam01551
859657006432	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
859657006433	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
859657006434	SEC-C motif; Region: SEC-C; pfam02810
859657006435	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
859657006436	heterotetramer interface [polypeptide binding]; other site
859657006437	active site pocket [active]
859657006438	cleavage site
859657006439	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
859657006440	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657006441	Walker A motif; other site
859657006442	ATP binding site [chemical binding]; other site
859657006443	Walker B motif; other site
859657006444	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
859657006445	active site
859657006446	8-oxo-dGMP binding site [chemical binding]; other site
859657006447	nudix motif; other site
859657006448	metal binding site [ion binding]; metal-binding site
859657006449	Domain of unknown function (DUF329); Region: DUF329; pfam03884
859657006450	hypothetical protein; Provisional; Region: PRK05287
859657006451	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
859657006452	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
859657006453	CoA-binding site [chemical binding]; other site
859657006454	ATP-binding [chemical binding]; other site
859657006455	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
859657006456	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
859657006457	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
859657006458	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
859657006459	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859657006460	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859657006461	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
859657006462	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
859657006463	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
859657006464	Walker A motif; other site
859657006465	ATP binding site [chemical binding]; other site
859657006466	Walker B motif; other site
859657006467	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
859657006468	Domain of unknown function DUF21; Region: DUF21; pfam01595
859657006469	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
859657006470	Transporter associated domain; Region: CorC_HlyC; smart01091
859657006471	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
859657006472	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
859657006473	substrate binding pocket [chemical binding]; other site
859657006474	chain length determination region; other site
859657006475	substrate-Mg2+ binding site; other site
859657006476	catalytic residues [active]
859657006477	aspartate-rich region 1; other site
859657006478	active site lid residues [active]
859657006479	aspartate-rich region 2; other site
859657006480	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
859657006481	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
859657006482	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
859657006483	GTPase CgtA; Reviewed; Region: obgE; PRK12299
859657006484	GTP1/OBG; Region: GTP1_OBG; pfam01018
859657006485	Obg GTPase; Region: Obg; cd01898
859657006486	G1 box; other site
859657006487	GTP/Mg2+ binding site [chemical binding]; other site
859657006488	Switch I region; other site
859657006489	G2 box; other site
859657006490	G3 box; other site
859657006491	Switch II region; other site
859657006492	G4 box; other site
859657006493	G5 box; other site
859657006494	gamma-glutamyl kinase; Provisional; Region: PRK05429
859657006495	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
859657006496	nucleotide binding site [chemical binding]; other site
859657006497	homotetrameric interface [polypeptide binding]; other site
859657006498	putative phosphate binding site [ion binding]; other site
859657006499	putative allosteric binding site; other site
859657006500	PUA domain; Region: PUA; pfam01472
859657006501	CNP1-like family; Region: CNP1; pfam08750
859657006502	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
859657006503	putative active site [active]
859657006504	Ap4A binding site [chemical binding]; other site
859657006505	nudix motif; other site
859657006506	putative metal binding site [ion binding]; other site
859657006507	prolyl-tRNA synthetase; Provisional; Region: PRK09194
859657006508	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
859657006509	dimer interface [polypeptide binding]; other site
859657006510	motif 1; other site
859657006511	active site
859657006512	motif 2; other site
859657006513	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
859657006514	putative deacylase active site [active]
859657006515	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
859657006516	active site
859657006517	motif 3; other site
859657006518	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
859657006519	anticodon binding site; other site
859657006520	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859657006521	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859657006522	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859657006523	catalytic residue [active]
859657006524	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
859657006525	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
859657006526	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859657006527	active site
859657006528	signal recognition particle protein; Provisional; Region: PRK10867
859657006529	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
859657006530	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
859657006531	P loop; other site
859657006532	GTP binding site [chemical binding]; other site
859657006533	Signal peptide binding domain; Region: SRP_SPB; pfam02978
859657006534	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
859657006535	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657006536	putative active site [active]
859657006537	heme pocket [chemical binding]; other site
859657006538	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657006539	dimer interface [polypeptide binding]; other site
859657006540	phosphorylation site [posttranslational modification]
859657006541	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657006542	ATP binding site [chemical binding]; other site
859657006543	Mg2+ binding site [ion binding]; other site
859657006544	G-X-G motif; other site
859657006545	Response regulator receiver domain; Region: Response_reg; pfam00072
859657006546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657006547	active site
859657006548	phosphorylation site [posttranslational modification]
859657006549	intermolecular recognition site; other site
859657006550	dimerization interface [polypeptide binding]; other site
859657006551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657006552	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
859657006553	Walker A motif; other site
859657006554	ATP binding site [chemical binding]; other site
859657006555	Walker B motif; other site
859657006556	arginine finger; other site
859657006557	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859657006558	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
859657006559	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
859657006560	amidase catalytic site [active]
859657006561	Zn binding residues [ion binding]; other site
859657006562	substrate binding site [chemical binding]; other site
859657006563	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
859657006564	ATP cone domain; Region: ATP-cone; pfam03477
859657006565	Class I ribonucleotide reductase; Region: RNR_I; cd01679
859657006566	active site
859657006567	dimer interface [polypeptide binding]; other site
859657006568	catalytic residues [active]
859657006569	effector binding site; other site
859657006570	R2 peptide binding site; other site
859657006571	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
859657006572	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
859657006573	dimer interface [polypeptide binding]; other site
859657006574	putative radical transfer pathway; other site
859657006575	diiron center [ion binding]; other site
859657006576	tyrosyl radical; other site
859657006577	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
859657006578	putative active site [active]
859657006579	Zn binding site [ion binding]; other site
859657006580	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
859657006581	EamA-like transporter family; Region: EamA; pfam00892
859657006582	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859657006583	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
859657006584	AsnC family; Region: AsnC_trans_reg; pfam01037
859657006585	Cache domain; Region: Cache_2; pfam08269
859657006586	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657006587	dimer interface [polypeptide binding]; other site
859657006588	putative CheW interface [polypeptide binding]; other site
859657006589	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
859657006590	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
859657006591	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
859657006592	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
859657006593	substrate binding site [chemical binding]; other site
859657006594	ATP binding site [chemical binding]; other site
859657006595	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
859657006596	dimer interface [polypeptide binding]; other site
859657006597	catalytic triad [active]
859657006598	peroxidatic and resolving cysteines [active]
859657006599	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
859657006600	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
859657006601	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
859657006602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657006603	S-adenosylmethionine binding site [chemical binding]; other site
859657006604	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
859657006605	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
859657006606	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
859657006607	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
859657006608	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
859657006609	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
859657006610	carboxyltransferase (CT) interaction site; other site
859657006611	biotinylation site [posttranslational modification]; other site
859657006612	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
859657006613	Dehydroquinase class II; Region: DHquinase_II; pfam01220
859657006614	trimer interface [polypeptide binding]; other site
859657006615	active site
859657006616	dimer interface [polypeptide binding]; other site
859657006617	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
859657006618	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859657006619	catalytic residues [active]
859657006620	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
859657006621	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
859657006622	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
859657006623	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
859657006624	Predicted esterase [General function prediction only]; Region: COG3150
859657006625	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657006626	Chorismate lyase; Region: Chor_lyase; cl01230
859657006627	Exoribonuclease R [Transcription]; Region: VacB; COG0557
859657006628	RNB domain; Region: RNB; pfam00773
859657006629	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
859657006630	TonB C terminal; Region: TonB_2; pfam13103
859657006631	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
859657006632	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
859657006633	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
859657006634	shikimate binding site; other site
859657006635	NAD(P) binding site [chemical binding]; other site
859657006636	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
859657006637	monofunctional biosynthetic peptidoglycan transglycosylase; Region: mono_pep_trsgly; TIGR02070
859657006638	Pectate lyase; Region: Pectate_lyase; pfam03211
859657006639	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
859657006640	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
859657006641	Cl binding site [ion binding]; other site
859657006642	oligomer interface [polypeptide binding]; other site
859657006643	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
859657006644	active site
859657006645	dimer interface [polypeptide binding]; other site
859657006646	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
859657006647	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
859657006648	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
859657006649	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
859657006650	tetramer interfaces [polypeptide binding]; other site
859657006651	binuclear metal-binding site [ion binding]; other site
859657006652	thiamine monophosphate kinase; Provisional; Region: PRK05731
859657006653	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
859657006654	ATP binding site [chemical binding]; other site
859657006655	dimerization interface [polypeptide binding]; other site
859657006656	malic enzyme; Reviewed; Region: PRK12862
859657006657	Malic enzyme, N-terminal domain; Region: malic; pfam00390
859657006658	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
859657006659	putative NAD(P) binding site [chemical binding]; other site
859657006660	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
859657006661	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
859657006662	active site
859657006663	barstar interaction site; other site
859657006664	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
859657006665	putative RNAase interaction site [polypeptide binding]; other site
859657006666	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
859657006667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
859657006668	RNA methyltransferase, RsmE family; Region: TIGR00046
859657006669	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
859657006670	putative dimer interface [polypeptide binding]; other site
859657006671	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859657006672	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
859657006673	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657006674	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
859657006675	dimerization interface [polypeptide binding]; other site
859657006676	substrate binding pocket [chemical binding]; other site
859657006677	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657006678	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657006679	trimer interface [polypeptide binding]; other site
859657006680	eyelet of channel; other site
859657006681	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
859657006682	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
859657006683	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
859657006684	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
859657006685	ligand binding site [chemical binding]; other site
859657006686	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
859657006687	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
859657006688	Walker A/P-loop; other site
859657006689	ATP binding site [chemical binding]; other site
859657006690	Q-loop/lid; other site
859657006691	ABC transporter signature motif; other site
859657006692	Walker B; other site
859657006693	D-loop; other site
859657006694	H-loop/switch region; other site
859657006695	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
859657006696	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859657006697	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
859657006698	TM-ABC transporter signature motif; other site
859657006699	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
859657006700	Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135
859657006701	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
859657006702	active site
859657006703	catalytic residues [active]
859657006704	short chain dehydrogenase; Provisional; Region: PRK07063
859657006705	classical (c) SDRs; Region: SDR_c; cd05233
859657006706	NAD(P) binding site [chemical binding]; other site
859657006707	active site
859657006708	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
859657006709	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
859657006710	active site
859657006711	intersubunit interface [polypeptide binding]; other site
859657006712	catalytic residue [active]
859657006713	galactonate dehydratase; Provisional; Region: PRK14017
859657006714	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
859657006715	putative active site pocket [active]
859657006716	putative metal binding site [ion binding]; other site
859657006717	transketolase; Reviewed; Region: PRK12753
859657006718	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
859657006719	TPP-binding site [chemical binding]; other site
859657006720	dimer interface [polypeptide binding]; other site
859657006721	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
859657006722	PYR/PP interface [polypeptide binding]; other site
859657006723	dimer interface [polypeptide binding]; other site
859657006724	TPP binding site [chemical binding]; other site
859657006725	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
859657006726	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
859657006727	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
859657006728	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
859657006729	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859657006730	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657006731	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657006732	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
859657006733	putative substrate binding pocket [chemical binding]; other site
859657006734	putative dimerization interface [polypeptide binding]; other site
859657006735	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
859657006736	metal binding site 2 [ion binding]; metal-binding site
859657006737	putative DNA binding helix; other site
859657006738	metal binding site 1 [ion binding]; metal-binding site
859657006739	dimer interface [polypeptide binding]; other site
859657006740	structural Zn2+ binding site [ion binding]; other site
859657006741	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
859657006742	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
859657006743	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
859657006744	dihydrodipicolinate reductase; Provisional; Region: PRK00048
859657006745	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
859657006746	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
859657006747	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
859657006748	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
859657006749	HIGH motif; other site
859657006750	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
859657006751	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859657006752	active site
859657006753	KMSKS motif; other site
859657006754	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
859657006755	tRNA binding surface [nucleotide binding]; other site
859657006756	Lipopolysaccharide-assembly; Region: LptE; cl01125
859657006757	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
859657006758	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
859657006759	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
859657006760	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
859657006761	putative catalytic cysteine [active]
859657006762	Predicted membrane protein [Function unknown]; Region: COG1981
859657006763	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
859657006764	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
859657006765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
859657006766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
859657006767	Response regulator receiver domain; Region: Response_reg; pfam00072
859657006768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657006769	active site
859657006770	phosphorylation site [posttranslational modification]
859657006771	intermolecular recognition site; other site
859657006772	dimerization interface [polypeptide binding]; other site
859657006773	Response regulator receiver domain; Region: Response_reg; pfam00072
859657006774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657006775	active site
859657006776	phosphorylation site [posttranslational modification]
859657006777	intermolecular recognition site; other site
859657006778	dimerization interface [polypeptide binding]; other site
859657006779	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657006780	dimer interface [polypeptide binding]; other site
859657006781	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657006782	phosphorylation site [posttranslational modification]
859657006783	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657006784	ATP binding site [chemical binding]; other site
859657006785	Mg2+ binding site [ion binding]; other site
859657006786	G-X-G motif; other site
859657006787	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657006788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657006789	dimer interface [polypeptide binding]; other site
859657006790	phosphorylation site [posttranslational modification]
859657006791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657006792	ATP binding site [chemical binding]; other site
859657006793	Mg2+ binding site [ion binding]; other site
859657006794	G-X-G motif; other site
859657006795	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657006796	S-adenosylmethionine binding site [chemical binding]; other site
859657006797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657006798	active site
859657006799	phosphorylation site [posttranslational modification]
859657006800	intermolecular recognition site; other site
859657006801	dimerization interface [polypeptide binding]; other site
859657006802	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
859657006803	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
859657006804	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
859657006805	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
859657006806	tetramerization interface [polypeptide binding]; other site
859657006807	active site
859657006808	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
859657006809	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
859657006810	ligand binding site [chemical binding]; other site
859657006811	homodimer interface [polypeptide binding]; other site
859657006812	NAD(P) binding site [chemical binding]; other site
859657006813	trimer interface B [polypeptide binding]; other site
859657006814	trimer interface A [polypeptide binding]; other site
859657006815	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859657006816	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859657006817	N-terminal plug; other site
859657006818	ligand-binding site [chemical binding]; other site
859657006819	Predicted membrane protein [Function unknown]; Region: COG3503
859657006820	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
859657006821	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657006822	putative substrate translocation pore; other site
859657006823	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657006824	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
859657006825	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657006826	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657006827	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859657006828	MarR family; Region: MarR_2; cl17246
859657006829	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
859657006830	nudix motif; other site
859657006831	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
859657006832	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
859657006833	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
859657006834	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
859657006835	active site
859657006836	FMN binding site [chemical binding]; other site
859657006837	substrate binding site [chemical binding]; other site
859657006838	3Fe-4S cluster binding site [ion binding]; other site
859657006839	putative glutathione S-transferase; Provisional; Region: PRK10357
859657006840	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
859657006841	putative C-terminal domain interface [polypeptide binding]; other site
859657006842	putative GSH binding site (G-site) [chemical binding]; other site
859657006843	putative dimer interface [polypeptide binding]; other site
859657006844	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
859657006845	dimer interface [polypeptide binding]; other site
859657006846	N-terminal domain interface [polypeptide binding]; other site
859657006847	putative substrate binding pocket (H-site) [chemical binding]; other site
859657006848	adenylosuccinate lyase; Provisional; Region: PRK09285
859657006849	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
859657006850	tetramer interface [polypeptide binding]; other site
859657006851	active site
859657006852	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
859657006853	Uncharacterized conserved protein [Function unknown]; Region: COG2353
859657006854	Uncharacterized conserved protein [Function unknown]; Region: COG2353
859657006855	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
859657006856	Protein export membrane protein; Region: SecD_SecF; pfam02355
859657006857	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
859657006858	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
859657006859	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
859657006860	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
859657006861	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
859657006862	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
859657006863	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
859657006864	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
859657006865	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
859657006866	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
859657006867	generic binding surface II; other site
859657006868	ssDNA binding site; other site
859657006869	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859657006870	ATP binding site [chemical binding]; other site
859657006871	putative Mg++ binding site [ion binding]; other site
859657006872	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859657006873	nucleotide binding region [chemical binding]; other site
859657006874	ATP-binding site [chemical binding]; other site
859657006875	Evidence 4 : Homologs of previously reported genes of unknown function
859657006876	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
859657006877	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
859657006878	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
859657006879	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
859657006880	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
859657006881	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
859657006882	putative ADP-binding pocket [chemical binding]; other site
859657006883	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859657006884	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
859657006885	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
859657006886	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859657006887	Integrase core domain; Region: rve; pfam00665
859657006888	Integrase core domain; Region: rve_3; pfam13683
859657006889	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
859657006890	Uncharacterized conserved protein [Function unknown]; Region: COG4275
859657006891	Evidence 4 : Homologs of previously reported genes of unknown function
859657006892	Evidence 4 : Homologs of previously reported genes of unknown function
859657006893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
859657006894	Walker A motif; other site
859657006895	ATP binding site [chemical binding]; other site
859657006896	YceI-like domain; Region: YceI; cl01001
859657006897	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
859657006898	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657006899	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
859657006900	dimerization interface [polypeptide binding]; other site
859657006901	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
859657006902	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
859657006903	tetramer interface [polypeptide binding]; other site
859657006904	heme binding pocket [chemical binding]; other site
859657006905	NADPH binding site [chemical binding]; other site
859657006906	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
859657006907	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
859657006908	dimerization interface [polypeptide binding]; other site
859657006909	DPS ferroxidase diiron center [ion binding]; other site
859657006910	ion pore; other site
859657006911	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
859657006912	UbiA prenyltransferase family; Region: UbiA; pfam01040
859657006913	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
859657006914	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
859657006915	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
859657006916	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859657006917	catalytic residue [active]
859657006918	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
859657006919	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
859657006920	Walker A motif; other site
859657006921	ATP binding site [chemical binding]; other site
859657006922	Walker B motif; other site
859657006923	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
859657006924	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
859657006925	Walker A motif; other site
859657006926	ATP binding site [chemical binding]; other site
859657006927	Walker B motif; other site
859657006928	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure
859657006929	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
859657006930	Type II transport protein GspH; Region: GspH; pfam12019
859657006931	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
859657006932	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
859657006933	Evidence 4 : Homologs of previously reported genes of unknown function
859657006934	Evidence 4 : Homologs of previously reported genes of unknown function
859657006935	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure
859657006936	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure
859657006937	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
859657006938	catalytic residues [active]
859657006939	dimer interface [polypeptide binding]; other site
859657006940	Predicted transcriptional regulator [Transcription]; Region: COG2378
859657006941	HTH domain; Region: HTH_11; pfam08279
859657006942	WYL domain; Region: WYL; pfam13280
859657006943	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
859657006944	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
859657006945	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859657006946	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
859657006947	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
859657006948	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
859657006949	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
859657006950	Cysteine-rich domain; Region: CCG; pfam02754
859657006951	Cysteine-rich domain; Region: CCG; pfam02754
859657006952	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
859657006953	FAD binding domain; Region: FAD_binding_4; pfam01565
859657006954	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
859657006955	FAD binding domain; Region: FAD_binding_4; pfam01565
859657006956	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
859657006957	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657006958	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
859657006959	dimerization interface [polypeptide binding]; other site
859657006960	substrate binding pocket [chemical binding]; other site
859657006961	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
859657006962	FAD binding domain; Region: FAD_binding_4; pfam01565
859657006963	ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636
859657006964	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
859657006965	Mechanosensitive ion channel; Region: MS_channel; pfam00924
859657006966	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859657006967	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657006968	non-specific DNA binding site [nucleotide binding]; other site
859657006969	salt bridge; other site
859657006970	sequence-specific DNA binding site [nucleotide binding]; other site
859657006971	HipA N-terminal domain; Region: Couple_hipA; pfam13657
859657006972	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
859657006973	HipA-like N-terminal domain; Region: HipA_N; pfam07805
859657006974	HipA-like C-terminal domain; Region: HipA_C; pfam07804
859657006975	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
859657006976	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
859657006977	protease TldD; Provisional; Region: tldD; PRK10735
859657006978	Predicted amidohydrolase [General function prediction only]; Region: COG0388
859657006979	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
859657006980	putative active site [active]
859657006981	catalytic triad [active]
859657006982	dimer interface [polypeptide binding]; other site
859657006983	Predicted membrane protein [Function unknown]; Region: COG3164
859657006984	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
859657006985	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
859657006986	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
859657006987	metal binding triad; other site
859657006988	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
859657006989	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
859657006990	metal binding triad; other site
859657006991	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
859657006992	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
859657006993	active site
859657006994	catalytic triad [active]
859657006995	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
859657006996	active site
859657006997	catalytic triad [active]
859657006998	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
859657006999	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
859657007000	Walker A/P-loop; other site
859657007001	ATP binding site [chemical binding]; other site
859657007002	Q-loop/lid; other site
859657007003	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
859657007004	ABC transporter signature motif; other site
859657007005	Walker B; other site
859657007006	D-loop; other site
859657007007	H-loop/switch region; other site
859657007008	NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155
859657007009	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
859657007010	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
859657007011	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
859657007012	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
859657007013	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657007014	DNA-binding site [nucleotide binding]; DNA binding site
859657007015	UTRA domain; Region: UTRA; pfam07702
859657007016	urocanate hydratase; Provisional; Region: PRK05414
859657007017	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
859657007018	active sites [active]
859657007019	tetramer interface [polypeptide binding]; other site
859657007020	formimidoylglutamase; Provisional; Region: PRK13775
859657007021	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
859657007022	putative active site [active]
859657007023	putative metal binding site [ion binding]; other site
859657007024	imidazolonepropionase; Validated; Region: PRK09356
859657007025	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
859657007026	active site
859657007027	ferrochelatase; Reviewed; Region: hemH; PRK00035
859657007028	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
859657007029	C-terminal domain interface [polypeptide binding]; other site
859657007030	active site
859657007031	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
859657007032	active site
859657007033	N-terminal domain interface [polypeptide binding]; other site
859657007034	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859657007035	RNA binding surface [nucleotide binding]; other site
859657007036	GrpE; Region: GrpE; pfam01025
859657007037	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
859657007038	dimer interface [polypeptide binding]; other site
859657007039	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
859657007040	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657007041	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657007042	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
859657007043	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
859657007044	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
859657007045	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
859657007046	nucleotide binding site [chemical binding]; other site
859657007047	chaperone protein DnaJ; Provisional; Region: PRK10767
859657007048	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
859657007049	HSP70 interaction site [polypeptide binding]; other site
859657007050	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
859657007051	Zn binding sites [ion binding]; other site
859657007052	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
859657007053	dimer interface [polypeptide binding]; other site
859657007054	aminodeoxychorismate synthase; Provisional; Region: PRK07508
859657007055	chorismate binding enzyme; Region: Chorismate_bind; cl10555
859657007056	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
859657007057	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
859657007058	homodimer interface [polypeptide binding]; other site
859657007059	substrate-cofactor binding pocket; other site
859657007060	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657007061	catalytic residue [active]
859657007062	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
859657007063	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657007064	Q-loop/lid; other site
859657007065	ABC transporter signature motif; other site
859657007066	Walker B; other site
859657007067	D-loop; other site
859657007068	H-loop/switch region; other site
859657007069	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
859657007070	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
859657007071	oligomerization interface [polypeptide binding]; other site
859657007072	active site
859657007073	metal binding site [ion binding]; metal-binding site
859657007074	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
859657007075	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
859657007076	Substrate-binding site [chemical binding]; other site
859657007077	Substrate specificity [chemical binding]; other site
859657007078	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
859657007079	catalytic center binding site [active]
859657007080	ATP binding site [chemical binding]; other site
859657007081	poly(A) polymerase; Region: pcnB; TIGR01942
859657007082	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
859657007083	active site
859657007084	NTP binding site [chemical binding]; other site
859657007085	metal binding triad [ion binding]; metal-binding site
859657007086	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
859657007087	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
859657007088	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
859657007089	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
859657007090	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
859657007091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657007092	Walker A motif; other site
859657007093	ATP binding site [chemical binding]; other site
859657007094	Walker B motif; other site
859657007095	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
859657007096	arginine finger; other site
859657007097	Domain of unknown function DUF20; Region: UPF0118; pfam01594
859657007098	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
859657007099	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
859657007100	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
859657007101	dimerization interface [polypeptide binding]; other site
859657007102	putative ATP binding site [chemical binding]; other site
859657007103	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
859657007104	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
859657007105	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
859657007106	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657007107	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
859657007108	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
859657007109	DNA binding site [nucleotide binding]
859657007110	active site
859657007111	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
859657007112	endonuclease III; Region: ENDO3c; smart00478
859657007113	minor groove reading motif; other site
859657007114	helix-hairpin-helix signature motif; other site
859657007115	substrate binding pocket [chemical binding]; other site
859657007116	active site
859657007117	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
859657007118	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826
859657007119	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657007120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657007121	Coenzyme A binding pocket [chemical binding]; other site
859657007122	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
859657007123	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
859657007124	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
859657007125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657007126	ATP binding site [chemical binding]; other site
859657007127	Mg2+ binding site [ion binding]; other site
859657007128	G-X-G motif; other site
859657007129	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
859657007130	ATP binding site [chemical binding]; other site
859657007131	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
859657007132	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
859657007133	mce related protein; Region: MCE; pfam02470
859657007134	mce related protein; Region: MCE; pfam02470
859657007135	mce related protein; Region: MCE; pfam02470
859657007136	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
859657007137	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657007138	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657007139	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
859657007140	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
859657007141	Uncharacterized conserved protein [Function unknown]; Region: COG2912
859657007142	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
859657007143	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
859657007144	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
859657007145	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
859657007146	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
859657007147	ornithine carbamoyltransferase; Provisional; Region: PRK00779
859657007148	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
859657007149	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
859657007150	argininosuccinate synthase; Validated; Region: PRK05370
859657007151	argininosuccinate synthase; Provisional; Region: PRK13820
859657007152	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
859657007153	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
859657007154	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
859657007155	active site
859657007156	nucleophile elbow; other site
859657007157	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
859657007158	FAD binding domain; Region: FAD_binding_4; pfam01565
859657007159	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
859657007160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
859657007161	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
859657007162	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
859657007163	active site
859657007164	tetramer interface [polypeptide binding]; other site
859657007165	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
859657007166	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
859657007167	putative deacylase active site [active]
859657007168	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
859657007169	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
859657007170	active site
859657007171	DNA binding site [nucleotide binding]
859657007172	Int/Topo IB signature motif; other site
859657007173	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
859657007174	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
859657007175	DNA binding site [nucleotide binding]
859657007176	active site
859657007177	epoxyqueuosine reductase; Region: TIGR00276
859657007178	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
859657007179	4Fe-4S binding domain; Region: Fer4_6; pfam12837
859657007180	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
859657007181	AMIN domain; Region: AMIN; pfam11741
859657007182	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
859657007183	active site
859657007184	metal binding site [ion binding]; metal-binding site
859657007185	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
859657007186	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
859657007187	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657007188	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657007189	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
859657007190	putative dimerization interface [polypeptide binding]; other site
859657007191	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
859657007192	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657007193	NAD(P) binding site [chemical binding]; other site
859657007194	active site
859657007195	adenylate kinase; Reviewed; Region: adk; PRK00279
859657007196	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
859657007197	AMP-binding site [chemical binding]; other site
859657007198	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
859657007199	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
859657007200	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
859657007201	Ligand binding site; other site
859657007202	oligomer interface; other site
859657007203	Uncharacterized conserved protein [Function unknown]; Region: COG2835
859657007204	tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906
859657007205	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
859657007206	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
859657007207	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
859657007208	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
859657007209	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
859657007210	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
859657007211	generic binding surface II; other site
859657007212	generic binding surface I; other site
859657007213	superoxide dismutase; Provisional; Region: PRK10543
859657007214	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
859657007215	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
859657007216	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
859657007217	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
859657007218	NAD(P) binding site [chemical binding]; other site
859657007219	homotetramer interface [polypeptide binding]; other site
859657007220	homodimer interface [polypeptide binding]; other site
859657007221	active site
859657007222	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
859657007223	active site
859657007224	putative substrate binding region [chemical binding]; other site
859657007225	Protein of unknown function (DUF2167); Region: DUF2167; cl01938
859657007226	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758
859657007227	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
859657007228	IHF dimer interface [polypeptide binding]; other site
859657007229	IHF - DNA interface [nucleotide binding]; other site
859657007230	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
859657007231	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
859657007232	NAD binding site [chemical binding]; other site
859657007233	active site
859657007234	metabolite-proton symporter; Region: 2A0106; TIGR00883
859657007235	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657007236	putative substrate translocation pore; other site
859657007237	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
859657007238	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
859657007239	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657007240	dimer interface [polypeptide binding]; other site
859657007241	conserved gate region; other site
859657007242	putative PBP binding loops; other site
859657007243	ABC-ATPase subunit interface; other site
859657007244	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
859657007245	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
859657007246	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859657007247	Zn2+ binding site [ion binding]; other site
859657007248	Mg2+ binding site [ion binding]; other site
859657007249	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657007250	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859657007251	substrate binding pocket [chemical binding]; other site
859657007252	membrane-bound complex binding site; other site
859657007253	hinge residues; other site
859657007254	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
859657007255	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
859657007256	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
859657007257	HipA N-terminal domain; Region: Couple_hipA; cl11853
859657007258	HipA-like N-terminal domain; Region: HipA_N; pfam07805
859657007259	HipA-like C-terminal domain; Region: HipA_C; pfam07804
859657007260	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859657007261	EamA-like transporter family; Region: EamA; pfam00892
859657007262	EamA-like transporter family; Region: EamA; pfam00892
859657007263	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
859657007264	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
859657007265	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
859657007266	DNA binding site [nucleotide binding]
859657007267	active site
859657007268	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
859657007269	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
859657007270	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657007271	AlkA N-terminal domain; Region: AlkA_N; pfam06029
859657007272	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
859657007273	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
859657007274	helix-hairpin-helix signature motif; other site
859657007275	substrate binding pocket [chemical binding]; other site
859657007276	active site
859657007277	glucose-1-dehydrogenase; Provisional; Region: PRK06947
859657007278	classical (c) SDRs; Region: SDR_c; cd05233
859657007279	NAD(P) binding site [chemical binding]; other site
859657007280	active site
859657007281	Predicted metalloprotease [General function prediction only]; Region: COG2321
859657007282	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
859657007283	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
859657007284	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
859657007285	Predicted membrane protein [Function unknown]; Region: COG2259
859657007286	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
859657007287	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657007288	putative substrate translocation pore; other site
859657007289	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657007290	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657007291	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657007292	putative effector binding pocket; other site
859657007293	dimerization interface [polypeptide binding]; other site
859657007294	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
859657007295	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657007296	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657007297	dimerization interface [polypeptide binding]; other site
859657007298	Predicted periplasmic protein [General function prediction only]; Region: COG3895
859657007299	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
859657007300	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
859657007301	Uncharacterized conserved protein [Function unknown]; Region: COG1430
859657007302	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
859657007303	Cytochrome c; Region: Cytochrom_C; pfam00034
859657007304	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
859657007305	active site
859657007306	metal binding site [ion binding]; metal-binding site
859657007307	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859657007308	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
859657007309	isocitrate dehydrogenase; Validated; Region: PRK07362
859657007310	isocitrate dehydrogenase; Reviewed; Region: PRK07006
859657007311	integrase; Provisional; Region: PRK09692
859657007312	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
859657007313	active site
859657007314	Int/Topo IB signature motif; other site
859657007315	Predicted transcriptional regulator [Transcription]; Region: COG2944
859657007316	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
859657007317	Transcriptional Coactivator p15 (PC4); Region: PC4; pfam02229
859657007318	Evidence 4 : Homologs of previously reported genes of unknown function
859657007319	AAA domain; Region: AAA_25; pfam13481
859657007320	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
859657007321	Walker A motif; other site
859657007322	ATP binding site [chemical binding]; other site
859657007323	Walker B motif; other site
859657007324	chromosome segregation protein; Provisional; Region: PRK03918
859657007325	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
859657007326	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859657007327	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859657007328	catalytic residue [active]
859657007329	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
859657007330	No apical meristem-associated C-terminal domain; Region: NAM-associated; pfam14303
859657007331	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859657007332	RHS Repeat; Region: RHS_repeat; cl11982
859657007333	RHS Repeat; Region: RHS_repeat; pfam05593
859657007334	RHS Repeat; Region: RHS_repeat; pfam05593
859657007335	RHS Repeat; Region: RHS_repeat; pfam05593
859657007336	RHS Repeat; Region: RHS_repeat; cl11982
859657007337	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
859657007338	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
859657007339	DNA-binding site [nucleotide binding]; DNA binding site
859657007340	RNA-binding motif; other site
859657007341	Uncharacterized conserved protein [Function unknown]; Region: COG2127
859657007342	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
859657007343	Clp amino terminal domain; Region: Clp_N; pfam02861
859657007344	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657007345	Walker A motif; other site
859657007346	ATP binding site [chemical binding]; other site
859657007347	Walker B motif; other site
859657007348	arginine finger; other site
859657007349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657007350	Walker A motif; other site
859657007351	ATP binding site [chemical binding]; other site
859657007352	Walker B motif; other site
859657007353	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
859657007354	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
859657007355	trimer interface [polypeptide binding]; other site
859657007356	active site
859657007357	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
859657007358	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
859657007359	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
859657007360	Flavoprotein; Region: Flavoprotein; pfam02441
859657007361	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
859657007362	Uncharacterized conserved protein [Function unknown]; Region: COG1434
859657007363	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
859657007364	putative active site [active]
859657007365	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
859657007366	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
859657007367	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859657007368	active site
859657007369	HIGH motif; other site
859657007370	nucleotide binding site [chemical binding]; other site
859657007371	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
859657007372	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
859657007373	active site
859657007374	KMSKS motif; other site
859657007375	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
859657007376	tRNA binding surface [nucleotide binding]; other site
859657007377	anticodon binding site; other site
859657007378	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
859657007379	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
859657007380	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
859657007381	active site
859657007382	Riboflavin kinase; Region: Flavokinase; smart00904
859657007383	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657007384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657007385	ATP binding site [chemical binding]; other site
859657007386	Mg2+ binding site [ion binding]; other site
859657007387	G-X-G motif; other site
859657007388	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859657007389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657007390	active site
859657007391	phosphorylation site [posttranslational modification]
859657007392	intermolecular recognition site; other site
859657007393	dimerization interface [polypeptide binding]; other site
859657007394	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657007395	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657007396	active site
859657007397	phosphorylation site [posttranslational modification]
859657007398	intermolecular recognition site; other site
859657007399	dimerization interface [polypeptide binding]; other site
859657007400	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657007401	DNA binding residues [nucleotide binding]
859657007402	dimerization interface [polypeptide binding]; other site
859657007403	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
859657007404	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
859657007405	active site
859657007406	cosubstrate binding site; other site
859657007407	substrate binding site [chemical binding]; other site
859657007408	catalytic site [active]
859657007409	ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563
859657007410	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657007411	S-adenosylmethionine binding site [chemical binding]; other site
859657007412	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
859657007413	PLD-like domain; Region: PLDc_2; pfam13091
859657007414	putative active site [active]
859657007415	catalytic site [active]
859657007416	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
859657007417	Mechanosensitive ion channel; Region: MS_channel; pfam00924
859657007418	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
859657007419	Fatty acid desaturase; Region: FA_desaturase; pfam00487
859657007420	Di-iron ligands [ion binding]; other site
859657007421	Transposase; Region: DDE_Tnp_ISL3; pfam01610
859657007422	quinolinate synthetase; Provisional; Region: PRK09375
859657007423	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
859657007424	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
859657007425	dimerization interface [polypeptide binding]; other site
859657007426	active site
859657007427	L-aspartate oxidase; Provisional; Region: PRK09077
859657007428	L-aspartate oxidase; Provisional; Region: PRK06175
859657007429	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
859657007430	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
859657007431	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
859657007432	hypothetical protein; Reviewed; Region: PRK00024
859657007433	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
859657007434	MPN+ (JAMM) motif; other site
859657007435	Zinc-binding site [ion binding]; other site
859657007436	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
859657007437	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
859657007438	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
859657007439	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
859657007440	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657007441	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
859657007442	dimerization interface [polypeptide binding]; other site
859657007443	ligand binding site [chemical binding]; other site
859657007444	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859657007445	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859657007446	TM-ABC transporter signature motif; other site
859657007447	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859657007448	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859657007449	TM-ABC transporter signature motif; other site
859657007450	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859657007451	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859657007452	Walker A/P-loop; other site
859657007453	ATP binding site [chemical binding]; other site
859657007454	Q-loop/lid; other site
859657007455	ABC transporter signature motif; other site
859657007456	Walker B; other site
859657007457	D-loop; other site
859657007458	H-loop/switch region; other site
859657007459	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859657007460	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859657007461	Walker A/P-loop; other site
859657007462	ATP binding site [chemical binding]; other site
859657007463	Q-loop/lid; other site
859657007464	ABC transporter signature motif; other site
859657007465	Walker B; other site
859657007466	D-loop; other site
859657007467	H-loop/switch region; other site
859657007468	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657007469	Coenzyme A binding pocket [chemical binding]; other site
859657007470	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
859657007471	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
859657007472	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859657007473	inhibitor-cofactor binding pocket; inhibition site
859657007474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657007475	catalytic residue [active]
859657007476	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
859657007477	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657007478	catalytic loop [active]
859657007479	iron binding site [ion binding]; other site
859657007480	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
859657007481	FAD binding pocket [chemical binding]; other site
859657007482	FAD binding motif [chemical binding]; other site
859657007483	phosphate binding motif [ion binding]; other site
859657007484	beta-alpha-beta structure motif; other site
859657007485	NAD binding pocket [chemical binding]; other site
859657007486	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657007487	NAD(P) binding site [chemical binding]; other site
859657007488	active site
859657007489	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
859657007490	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657007491	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657007492	metal binding site [ion binding]; metal-binding site
859657007493	active site
859657007494	I-site; other site
859657007495	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
859657007496	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
859657007497	Cl- selectivity filter; other site
859657007498	Cl- binding residues [ion binding]; other site
859657007499	pore gating glutamate residue; other site
859657007500	dimer interface [polypeptide binding]; other site
859657007501	FOG: CBS domain [General function prediction only]; Region: COG0517
859657007502	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
859657007503	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859657007504	MarR family; Region: MarR_2; pfam12802
859657007505	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
859657007506	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
859657007507	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657007508	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
859657007509	putative ligand binding site [chemical binding]; other site
859657007510	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
859657007511	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657007512	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
859657007513	substrate binding site [chemical binding]; other site
859657007514	dimerization interface [polypeptide binding]; other site
859657007515	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
859657007516	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
859657007517	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
859657007518	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
859657007519	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
859657007520	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
859657007521	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
859657007522	Active Sites [active]
859657007523	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
859657007524	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
859657007525	Active Sites [active]
859657007526	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
859657007527	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
859657007528	CysD dimerization site [polypeptide binding]; other site
859657007529	G1 box; other site
859657007530	putative GEF interaction site [polypeptide binding]; other site
859657007531	GTP/Mg2+ binding site [chemical binding]; other site
859657007532	Switch I region; other site
859657007533	G2 box; other site
859657007534	G3 box; other site
859657007535	Switch II region; other site
859657007536	G4 box; other site
859657007537	G5 box; other site
859657007538	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
859657007539	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
859657007540	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
859657007541	active site
859657007542	SAM binding site [chemical binding]; other site
859657007543	homodimer interface [polypeptide binding]; other site
859657007544	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
859657007545	putative substrate binding pocket [chemical binding]; other site
859657007546	trimer interface [polypeptide binding]; other site
859657007547	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
859657007548	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
859657007549	putative active site [active]
859657007550	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
859657007551	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
859657007552	Predicted permeases [General function prediction only]; Region: COG0795
859657007553	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
859657007554	multifunctional aminopeptidase A; Provisional; Region: PRK00913
859657007555	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
859657007556	interface (dimer of trimers) [polypeptide binding]; other site
859657007557	Substrate-binding/catalytic site; other site
859657007558	Zn-binding sites [ion binding]; other site
859657007559	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
859657007560	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
859657007561	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
859657007562	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657007563	The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453
859657007564	putative dimerization interface [polypeptide binding]; other site
859657007565	putative substrate binding pocket [chemical binding]; other site
859657007566	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
859657007567	Protein of unknown function (DUF541); Region: SIMPL; cl01077
859657007568	Uncharacterized conserved protein [Function unknown]; Region: COG2947
859657007569	Cell division protein ZapA; Region: ZapA; pfam05164
859657007570	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
859657007571	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
859657007572	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859657007573	N-terminal plug; other site
859657007574	ligand-binding site [chemical binding]; other site
859657007575	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
859657007576	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
859657007577	dimer interface [polypeptide binding]; other site
859657007578	putative PBP binding regions; other site
859657007579	ABC-ATPase subunit  interface; other site
859657007580	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
859657007581	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
859657007582	Walker A/P-loop; other site
859657007583	ATP binding site [chemical binding]; other site
859657007584	Q-loop/lid; other site
859657007585	ABC transporter signature motif; other site
859657007586	Walker B; other site
859657007587	D-loop; other site
859657007588	H-loop/switch region; other site
859657007589	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
859657007590	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
859657007591	putative dimer interface [polypeptide binding]; other site
859657007592	active site pocket [active]
859657007593	putative cataytic base [active]
859657007594	cobalamin synthase; Reviewed; Region: cobS; PRK00235
859657007595	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
859657007596	catalytic core [active]
859657007597	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
859657007598	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
859657007599	cobalamin binding residues [chemical binding]; other site
859657007600	putative BtuC binding residues; other site
859657007601	dimer interface [polypeptide binding]; other site
859657007602	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
859657007603	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657007604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657007605	homodimer interface [polypeptide binding]; other site
859657007606	catalytic residue [active]
859657007607	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
859657007608	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
859657007609	homotrimer interface [polypeptide binding]; other site
859657007610	Walker A motif; other site
859657007611	GTP binding site [chemical binding]; other site
859657007612	Walker B motif; other site
859657007613	cobyric acid synthase; Provisional; Region: PRK00784
859657007614	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
859657007615	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
859657007616	catalytic triad [active]
859657007617	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
859657007618	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
859657007619	P-loop; other site
859657007620	Magnesium ion binding site [ion binding]; other site
859657007621	pantoate--beta-alanine ligase; Region: panC; TIGR00018
859657007622	Pantoate-beta-alanine ligase; Region: PanC; cd00560
859657007623	active site
859657007624	ATP-binding site [chemical binding]; other site
859657007625	pantoate-binding site; other site
859657007626	HXXH motif; other site
859657007627	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
859657007628	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
859657007629	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
859657007630	Surface antigen; Region: Bac_surface_Ag; pfam01103
859657007631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
859657007632	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
859657007633	Family of unknown function (DUF490); Region: DUF490; pfam04357
859657007634	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
859657007635	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
859657007636	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
859657007637	active site
859657007638	HIGH motif; other site
859657007639	KMSKS motif; other site
859657007640	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
859657007641	tRNA binding surface [nucleotide binding]; other site
859657007642	anticodon binding site; other site
859657007643	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
859657007644	dimer interface [polypeptide binding]; other site
859657007645	putative tRNA-binding site [nucleotide binding]; other site
859657007646	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
859657007647	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
859657007648	ligand binding site [chemical binding]; other site
859657007649	antiporter inner membrane protein; Provisional; Region: PRK11670
859657007650	Domain of unknown function DUF59; Region: DUF59; pfam01883
859657007651	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
859657007652	Walker A motif; other site
859657007653	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
859657007654	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
859657007655	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
859657007656	4Fe-4S binding domain; Region: Fer4; pfam00037
859657007657	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
859657007658	4Fe-4S binding domain; Region: Fer4; pfam00037
859657007659	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
859657007660	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
859657007661	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
859657007662	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
859657007663	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
859657007664	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
859657007665	[4Fe-4S] binding site [ion binding]; other site
859657007666	molybdopterin cofactor binding site; other site
859657007667	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
859657007668	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
859657007669	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
859657007670	molybdopterin cofactor binding site; other site
859657007671	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
859657007672	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
859657007673	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
859657007674	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
859657007675	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
859657007676	E-class dimer interface [polypeptide binding]; other site
859657007677	P-class dimer interface [polypeptide binding]; other site
859657007678	active site
859657007679	Cu2+ binding site [ion binding]; other site
859657007680	Zn2+ binding site [ion binding]; other site
859657007681	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
859657007682	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
859657007683	trimer interface [polypeptide binding]; other site
859657007684	active site
859657007685	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
859657007686	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
859657007687	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859657007688	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859657007689	catalytic residue [active]
859657007690	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
859657007691	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
859657007692	PLD-like domain; Region: PLDc_2; pfam13091
859657007693	homodimer interface [polypeptide binding]; other site
859657007694	putative active site [active]
859657007695	catalytic site [active]
859657007696	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859657007697	putative active site [active]
859657007698	Domain of unknown function DUF87; Region: DUF87; pfam01935
859657007699	AAA-like domain; Region: AAA_10; pfam12846
859657007700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
859657007701	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
859657007702	argininosuccinate lyase; Provisional; Region: PRK00855
859657007703	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
859657007704	active sites [active]
859657007705	tetramer interface [polypeptide binding]; other site
859657007706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
859657007707	Anti-sigma-K factor rskA; Region: RskA; pfam10099
859657007708	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
859657007709	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657007710	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657007711	DNA binding residues [nucleotide binding]
859657007712	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
859657007713	dinuclear metal binding motif [ion binding]; other site
859657007714	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
859657007715	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
859657007716	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
859657007717	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
859657007718	domain interfaces; other site
859657007719	active site
859657007720	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
859657007721	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
859657007722	active site
859657007723	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
859657007724	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
859657007725	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
859657007726	HemY protein N-terminus; Region: HemY_N; pfam07219
859657007727	Cytochrome b [Energy production and conversion]; Region: COG3658
859657007728	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
859657007729	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657007730	D-galactonate transporter; Region: 2A0114; TIGR00893
859657007731	putative substrate translocation pore; other site
859657007732	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
859657007733	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
859657007734	putative NAD(P) binding site [chemical binding]; other site
859657007735	active site
859657007736	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859657007737	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
859657007738	NAD(P) binding site [chemical binding]; other site
859657007739	catalytic residues [active]
859657007740	catalytic residues [active]
859657007741	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
859657007742	dimer interface [polypeptide binding]; other site
859657007743	substrate binding site [chemical binding]; other site
859657007744	metal binding sites [ion binding]; metal-binding site
859657007745	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
859657007746	Protein of unknown function, DUF482; Region: DUF482; pfam04339
859657007747	NAD synthetase; Provisional; Region: PRK13981
859657007748	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
859657007749	multimer interface [polypeptide binding]; other site
859657007750	active site
859657007751	catalytic triad [active]
859657007752	protein interface 1 [polypeptide binding]; other site
859657007753	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
859657007754	homodimer interface [polypeptide binding]; other site
859657007755	NAD binding pocket [chemical binding]; other site
859657007756	ATP binding pocket [chemical binding]; other site
859657007757	Mg binding site [ion binding]; other site
859657007758	active-site loop [active]
859657007759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657007760	S-adenosylmethionine binding site [chemical binding]; other site
859657007761	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
859657007762	Nitrogen regulatory protein P-II; Region: P-II; smart00938
859657007763	Predicted membrane protein [Function unknown]; Region: COG2860
859657007764	UPF0126 domain; Region: UPF0126; pfam03458
859657007765	UPF0126 domain; Region: UPF0126; pfam03458
859657007766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
859657007767	Smr domain; Region: Smr; pfam01713
859657007768	thioredoxin reductase; Provisional; Region: PRK10262
859657007769	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859657007770	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859657007771	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
859657007772	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
859657007773	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
859657007774	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
859657007775	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
859657007776	recombination factor protein RarA; Reviewed; Region: PRK13342
859657007777	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657007778	Walker A motif; other site
859657007779	ATP binding site [chemical binding]; other site
859657007780	Walker B motif; other site
859657007781	arginine finger; other site
859657007782	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
859657007783	seryl-tRNA synthetase; Provisional; Region: PRK05431
859657007784	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
859657007785	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
859657007786	dimer interface [polypeptide binding]; other site
859657007787	active site
859657007788	motif 1; other site
859657007789	motif 2; other site
859657007790	motif 3; other site
859657007791	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
859657007792	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
859657007793	active site
859657007794	motif I; other site
859657007795	motif II; other site
859657007796	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657007797	Helix-turn-helix domain; Region: HTH_18; pfam12833
859657007798	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657007799	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
859657007800	active site
859657007801	catalytic triad [active]
859657007802	calcium binding site [ion binding]; other site
859657007803	Methyltransferase domain; Region: Methyltransf_26; pfam13659
859657007804	VirK protein; Region: VirK; pfam06903
859657007805	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
859657007806	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
859657007807	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
859657007808	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
859657007809	DNA binding residues [nucleotide binding]
859657007810	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
859657007811	Domain of unknown function DUF21; Region: DUF21; pfam01595
859657007812	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
859657007813	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
859657007814	Transporter associated domain; Region: CorC_HlyC; smart01091
859657007815	Uncharacterized conserved protein [Function unknown]; Region: COG3868
859657007816	C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922
859657007817	putative active site [active]
859657007818	Tetratricopeptide repeat; Region: TPR_15; pfam13429
859657007819	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
859657007820	GAF domain; Region: GAF_3; pfam13492
859657007821	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
859657007822	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
859657007823	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859657007824	Predicted membrane protein [Function unknown]; Region: COG4267
859657007825	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657007826	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
859657007827	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
859657007828	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657007829	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859657007830	substrate binding pocket [chemical binding]; other site
859657007831	membrane-bound complex binding site; other site
859657007832	hinge residues; other site
859657007833	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
859657007834	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859657007835	Walker A/P-loop; other site
859657007836	ATP binding site [chemical binding]; other site
859657007837	Q-loop/lid; other site
859657007838	ABC transporter signature motif; other site
859657007839	Walker B; other site
859657007840	D-loop; other site
859657007841	H-loop/switch region; other site
859657007842	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657007843	dimer interface [polypeptide binding]; other site
859657007844	conserved gate region; other site
859657007845	putative PBP binding loops; other site
859657007846	ABC-ATPase subunit interface; other site
859657007847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657007848	dimer interface [polypeptide binding]; other site
859657007849	conserved gate region; other site
859657007850	putative PBP binding loops; other site
859657007851	ABC-ATPase subunit interface; other site
859657007852	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859657007853	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657007854	substrate binding pocket [chemical binding]; other site
859657007855	membrane-bound complex binding site; other site
859657007856	hinge residues; other site
859657007857	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
859657007858	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859657007859	Bacterial transcriptional regulator; Region: IclR; pfam01614
859657007860	Coenzyme A transferase; Region: CoA_trans; cl17247
859657007861	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
859657007862	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
859657007863	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859657007864	dimer interface [polypeptide binding]; other site
859657007865	active site
859657007866	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
859657007867	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
859657007868	tetramer interface [polypeptide binding]; other site
859657007869	active site
859657007870	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
859657007871	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
859657007872	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
859657007873	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859657007874	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859657007875	TM-ABC transporter signature motif; other site
859657007876	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859657007877	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859657007878	TM-ABC transporter signature motif; other site
859657007879	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859657007880	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859657007881	Walker A/P-loop; other site
859657007882	ATP binding site [chemical binding]; other site
859657007883	Q-loop/lid; other site
859657007884	ABC transporter signature motif; other site
859657007885	Walker B; other site
859657007886	D-loop; other site
859657007887	H-loop/switch region; other site
859657007888	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859657007889	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859657007890	Walker A/P-loop; other site
859657007891	ATP binding site [chemical binding]; other site
859657007892	Q-loop/lid; other site
859657007893	ABC transporter signature motif; other site
859657007894	Walker B; other site
859657007895	D-loop; other site
859657007896	H-loop/switch region; other site
859657007897	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859657007898	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
859657007899	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657007900	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657007901	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
859657007902	substrate binding pocket [chemical binding]; other site
859657007903	dimerization interface [polypeptide binding]; other site
859657007904	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
859657007905	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859657007906	Predicted extracellular endo alpha-1,4 polygalactosaminidase or related polysaccharide hydrolase [Carbohydrate transport and metabolism]; Region: COG2342
859657007907	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
859657007908	rRNA binding site [nucleotide binding]; other site
859657007909	predicted 30S ribosome binding site; other site
859657007910	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
859657007911	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
859657007912	active site
859657007913	tetramer interface; other site
859657007914	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
859657007915	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859657007916	active site
859657007917	HIGH motif; other site
859657007918	nucleotide binding site [chemical binding]; other site
859657007919	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
859657007920	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
859657007921	active site
859657007922	KMSKS motif; other site
859657007923	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
859657007924	tRNA binding surface [nucleotide binding]; other site
859657007925	anticodon binding site; other site
859657007926	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
859657007927	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
859657007928	Part of AAA domain; Region: AAA_19; pfam13245
859657007929	Family description; Region: UvrD_C_2; pfam13538
859657007930	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
859657007931	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
859657007932	putative active site [active]
859657007933	putative substrate binding site [chemical binding]; other site
859657007934	ATP binding site [chemical binding]; other site
859657007935	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
859657007936	DNA polymerase I; Provisional; Region: PRK05755
859657007937	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
859657007938	active site
859657007939	metal binding site 1 [ion binding]; metal-binding site
859657007940	putative 5' ssDNA interaction site; other site
859657007941	metal binding site 3; metal-binding site
859657007942	metal binding site 2 [ion binding]; metal-binding site
859657007943	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
859657007944	putative DNA binding site [nucleotide binding]; other site
859657007945	putative metal binding site [ion binding]; other site
859657007946	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
859657007947	active site
859657007948	catalytic site [active]
859657007949	substrate binding site [chemical binding]; other site
859657007950	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
859657007951	active site
859657007952	DNA binding site [nucleotide binding]
859657007953	catalytic site [active]
859657007954	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
859657007955	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859657007956	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
859657007957	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
859657007958	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
859657007959	ZIP Zinc transporter; Region: Zip; pfam02535
859657007960	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
859657007961	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
859657007962	active site residue [active]
859657007963	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
859657007964	active site residue [active]
859657007965	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859657007966	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
859657007967	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
859657007968	[2Fe-2S] cluster binding site [ion binding]; other site
859657007969	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
859657007970	alpha subunit interface [polypeptide binding]; other site
859657007971	active site
859657007972	substrate binding site [chemical binding]; other site
859657007973	Fe binding site [ion binding]; other site
859657007974	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
859657007975	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
859657007976	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
859657007977	substrate binding pocket [chemical binding]; other site
859657007978	chain length determination region; other site
859657007979	substrate-Mg2+ binding site; other site
859657007980	catalytic residues [active]
859657007981	aspartate-rich region 1; other site
859657007982	active site lid residues [active]
859657007983	aspartate-rich region 2; other site
859657007984	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
859657007985	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
859657007986	TPP-binding site; other site
859657007987	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
859657007988	PYR/PP interface [polypeptide binding]; other site
859657007989	dimer interface [polypeptide binding]; other site
859657007990	TPP binding site [chemical binding]; other site
859657007991	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
859657007992	putative GTP cyclohydrolase; Provisional; Region: PRK13674
859657007993	UGMP family protein; Validated; Region: PRK09604
859657007994	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
859657007995	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
859657007996	HI0933-like protein; Region: HI0933_like; pfam03486
859657007997	Yqey-like protein; Region: YqeY; pfam09424
859657007998	DNA primase; Validated; Region: dnaG; PRK05667
859657007999	CHC2 zinc finger; Region: zf-CHC2; pfam01807
859657008000	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
859657008001	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
859657008002	active site
859657008003	metal binding site [ion binding]; metal-binding site
859657008004	interdomain interaction site; other site
859657008005	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
859657008006	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
859657008007	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
859657008008	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
859657008009	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
859657008010	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
859657008011	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657008012	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
859657008013	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657008014	DNA binding residues [nucleotide binding]
859657008015	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657008016	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657008017	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657008018	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
859657008019	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
859657008020	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
859657008021	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
859657008022	ATP binding site [chemical binding]; other site
859657008023	Mg++ binding site [ion binding]; other site
859657008024	motif III; other site
859657008025	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859657008026	nucleotide binding region [chemical binding]; other site
859657008027	ATP-binding site [chemical binding]; other site
859657008028	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
859657008029	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
859657008030	active site
859657008031	HIGH motif; other site
859657008032	nucleotide binding site [chemical binding]; other site
859657008033	active site
859657008034	KMSKS motif; other site
859657008035	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
859657008036	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657008037	The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431
859657008038	putative dimerization interface [polypeptide binding]; other site
859657008039	Pirin-related protein [General function prediction only]; Region: COG1741
859657008040	Pirin; Region: Pirin; pfam02678
859657008041	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
859657008042	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859657008043	rhodanese superfamily protein; Provisional; Region: PRK05320
859657008044	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
859657008045	active site residue [active]
859657008046	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
859657008047	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
859657008048	putative active site [active]
859657008049	putative PHP Thumb interface [polypeptide binding]; other site
859657008050	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
859657008051	generic binding surface II; other site
859657008052	generic binding surface I; other site
859657008053	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
859657008054	O-Antigen ligase; Region: Wzy_C; pfam04932
859657008055	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
859657008056	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
859657008057	active site
859657008058	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
859657008059	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
859657008060	putative metal binding site; other site
859657008061	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
859657008062	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
859657008063	active site
859657008064	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
859657008065	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
859657008066	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
859657008067	Walker A/P-loop; other site
859657008068	ATP binding site [chemical binding]; other site
859657008069	Q-loop/lid; other site
859657008070	ABC transporter signature motif; other site
859657008071	Walker B; other site
859657008072	D-loop; other site
859657008073	H-loop/switch region; other site
859657008074	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
859657008075	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
859657008076	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
859657008077	ribonuclease G; Provisional; Region: PRK11712
859657008078	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
859657008079	homodimer interface [polypeptide binding]; other site
859657008080	oligonucleotide binding site [chemical binding]; other site
859657008081	Maf-like protein; Region: Maf; pfam02545
859657008082	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
859657008083	active site
859657008084	dimer interface [polypeptide binding]; other site
859657008085	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
859657008086	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
859657008087	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
859657008088	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
859657008089	active site
859657008090	(T/H)XGH motif; other site
859657008091	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
859657008092	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
859657008093	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
859657008094	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
859657008095	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
859657008096	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
859657008097	hypothetical protein; Validated; Region: PRK00110
859657008098	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
859657008099	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
859657008100	Walker A motif; other site
859657008101	ATP binding site [chemical binding]; other site
859657008102	Zonular occludens toxin (Zot); Region: Zot; cl17485
859657008103	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859657008104	active site
859657008105	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
859657008106	EamA-like transporter family; Region: EamA; pfam00892
859657008107	EamA-like transporter family; Region: EamA; pfam00892
859657008108	short chain dehydrogenase; Provisional; Region: PRK08339
859657008109	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
859657008110	putative NAD(P) binding site [chemical binding]; other site
859657008111	putative active site [active]
859657008112	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
859657008113	active site
859657008114	dimer interfaces [polypeptide binding]; other site
859657008115	catalytic residues [active]
859657008116	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
859657008117	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
859657008118	NADP binding site [chemical binding]; other site
859657008119	dimer interface [polypeptide binding]; other site
859657008120	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
859657008121	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657008122	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657008123	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
859657008124	Putative amidotransferase; Region: DUF4066; pfam13278
859657008125	conserved cys residue [active]
859657008126	cyanate hydratase; Validated; Region: PRK02866
859657008127	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
859657008128	oligomer interface [polypeptide binding]; other site
859657008129	active site
859657008130	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
859657008131	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657008132	DNA-binding site [nucleotide binding]; DNA binding site
859657008133	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657008134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657008135	homodimer interface [polypeptide binding]; other site
859657008136	catalytic residue [active]
859657008137	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
859657008138	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859657008139	active site
859657008140	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
859657008141	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
859657008142	putative ligand binding site [chemical binding]; other site
859657008143	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859657008144	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
859657008145	TM-ABC transporter signature motif; other site
859657008146	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859657008147	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
859657008148	TM-ABC transporter signature motif; other site
859657008149	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
859657008150	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
859657008151	Walker A/P-loop; other site
859657008152	ATP binding site [chemical binding]; other site
859657008153	Q-loop/lid; other site
859657008154	ABC transporter signature motif; other site
859657008155	Walker B; other site
859657008156	D-loop; other site
859657008157	H-loop/switch region; other site
859657008158	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
859657008159	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657008160	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
859657008161	putative substrate translocation pore; other site
859657008162	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
859657008163	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
859657008164	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
859657008165	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
859657008166	putative active site [active]
859657008167	Predicted membrane protein [Function unknown]; Region: COG3819
859657008168	Predicted membrane protein [Function unknown]; Region: COG3817
859657008169	Protein of unknown function (DUF979); Region: DUF979; pfam06166
859657008170	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
859657008171	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
859657008172	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
859657008173	putative substrate binding pocket [chemical binding]; other site
859657008174	AC domain interface; other site
859657008175	catalytic triad [active]
859657008176	AB domain interface; other site
859657008177	interchain disulfide; other site
859657008178	conserved hypothetical protein; Region: TIGR02284
859657008179	ribonuclease Z; Provisional; Region: PRK02126
859657008180	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
859657008181	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657008182	FeS/SAM binding site; other site
859657008183	HemN C-terminal domain; Region: HemN_C; pfam06969
859657008184	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
859657008185	active site
859657008186	dimerization interface [polypeptide binding]; other site
859657008187	ribonuclease PH; Reviewed; Region: rph; PRK00173
859657008188	Ribonuclease PH; Region: RNase_PH_bact; cd11362
859657008189	hexamer interface [polypeptide binding]; other site
859657008190	active site
859657008191	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
859657008192	active site
859657008193	Protein kinase domain; Region: Pkinase; pfam00069
859657008194	Catalytic domain of Protein Kinases; Region: PKc; cd00180
859657008195	active site
859657008196	ATP binding site [chemical binding]; other site
859657008197	substrate binding site [chemical binding]; other site
859657008198	activation loop (A-loop); other site
859657008199	hypothetical protein; Provisional; Region: PRK11820
859657008200	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
859657008201	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
859657008202	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
859657008203	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
859657008204	catalytic site [active]
859657008205	G-X2-G-X-G-K; other site
859657008206	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
859657008207	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
859657008208	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859657008209	Zn2+ binding site [ion binding]; other site
859657008210	Mg2+ binding site [ion binding]; other site
859657008211	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
859657008212	synthetase active site [active]
859657008213	NTP binding site [chemical binding]; other site
859657008214	metal binding site [ion binding]; metal-binding site
859657008215	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
859657008216	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
859657008217	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
859657008218	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
859657008219	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
859657008220	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator
859657008221	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
859657008222	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
859657008223	BON domain; Region: BON; pfam04972
859657008224	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859657008225	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
859657008226	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
859657008227	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
859657008228	Walker A motif; other site
859657008229	ATP binding site [chemical binding]; other site
859657008230	Walker B motif; other site
859657008231	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
859657008232	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859657008233	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859657008234	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
859657008235	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
859657008236	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
859657008237	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
859657008238	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
859657008239	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
859657008240	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
859657008241	Secretin and TonB N terminus short domain; Region: STN; smart00965
859657008242	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859657008243	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859657008244	Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546
859657008245	dockerin binding interface; other site
859657008246	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
859657008247	putative active site [active]
859657008248	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859657008249	RHS Repeat; Region: RHS_repeat; pfam05593
859657008250	RHS Repeat; Region: RHS_repeat; pfam05593
859657008251	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
859657008252	RHS Repeat; Region: RHS_repeat; pfam05593
859657008253	RHS Repeat; Region: RHS_repeat; pfam05593
859657008254	RHS Repeat; Region: RHS_repeat; pfam05593
859657008255	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
859657008256	sugar binding site [chemical binding]; other site
859657008257	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
859657008258	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859657008259	RHS Repeat; Region: RHS_repeat; pfam05593
859657008260	RHS Repeat; Region: RHS_repeat; pfam05593
859657008261	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859657008262	Homeodomain-like domain; Region: HTH_23; pfam13384
859657008263	Winged helix-turn helix; Region: HTH_29; pfam13551
859657008264	Winged helix-turn helix; Region: HTH_33; pfam13592
859657008265	DDE superfamily endonuclease; Region: DDE_3; pfam13358
859657008266	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
859657008267	RHS Repeat; Region: RHS_repeat; cl11982
859657008268	RHS Repeat; Region: RHS_repeat; pfam05593
859657008269	RHS Repeat; Region: RHS_repeat; cl11982
859657008270	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
859657008271	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
859657008272	TrkA-C domain; Region: TrkA_C; pfam02080
859657008273	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
859657008274	malate dehydrogenase; Provisional; Region: PRK13529
859657008275	Malic enzyme, N-terminal domain; Region: malic; pfam00390
859657008276	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
859657008277	NAD(P) binding site [chemical binding]; other site
859657008278	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
859657008279	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
859657008280	phosphate binding site [ion binding]; other site
859657008281	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
859657008282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657008283	active site
859657008284	phosphorylation site [posttranslational modification]
859657008285	intermolecular recognition site; other site
859657008286	dimerization interface [polypeptide binding]; other site
859657008287	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657008288	Walker A motif; other site
859657008289	ATP binding site [chemical binding]; other site
859657008290	Walker B motif; other site
859657008291	arginine finger; other site
859657008292	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859657008293	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
859657008294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657008295	dimer interface [polypeptide binding]; other site
859657008296	phosphorylation site [posttranslational modification]
859657008297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657008298	ATP binding site [chemical binding]; other site
859657008299	Mg2+ binding site [ion binding]; other site
859657008300	G-X-G motif; other site
859657008301	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657008302	catalytic loop [active]
859657008303	iron binding site [ion binding]; other site
859657008304	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
859657008305	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
859657008306	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
859657008307	L-aspartate oxidase; Provisional; Region: PRK06175
859657008308	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
859657008309	SLBB domain; Region: SLBB; pfam10531
859657008310	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
859657008311	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
859657008312	AMP binding site [chemical binding]; other site
859657008313	metal binding site [ion binding]; metal-binding site
859657008314	active site
859657008315	aminopeptidase N; Provisional; Region: pepN; PRK14015
859657008316	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
859657008317	active site
859657008318	Zn binding site [ion binding]; other site
859657008319	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
859657008320	malic enzyme; Reviewed; Region: PRK12862
859657008321	Malic enzyme, N-terminal domain; Region: malic; pfam00390
859657008322	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
859657008323	putative NAD(P) binding site [chemical binding]; other site
859657008324	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
859657008325	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657008326	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657008327	trimer interface [polypeptide binding]; other site
859657008328	eyelet of channel; other site
859657008329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
859657008330	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
859657008331	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
859657008332	active site
859657008333	catalytic site [active]
859657008334	tetramer interface [polypeptide binding]; other site
859657008335	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
859657008336	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
859657008337	active site
859657008338	putative substrate binding pocket [chemical binding]; other site
859657008339	xanthine permease; Region: pbuX; TIGR03173
859657008340	Transcriptional regulators [Transcription]; Region: GntR; COG1802
859657008341	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657008342	DNA-binding site [nucleotide binding]; DNA binding site
859657008343	FCD domain; Region: FCD; pfam07729
859657008344	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
859657008345	active site
859657008346	homotetramer interface [polypeptide binding]; other site
859657008347	Predicted membrane protein [Function unknown]; Region: COG3748
859657008348	Protein of unknown function (DUF989); Region: DUF989; pfam06181
859657008349	Cytochrome c; Region: Cytochrom_C; pfam00034
859657008350	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
859657008351	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
859657008352	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
859657008353	putative active site [active]
859657008354	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
859657008355	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
859657008356	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859657008357	Walker A/P-loop; other site
859657008358	ATP binding site [chemical binding]; other site
859657008359	Q-loop/lid; other site
859657008360	ABC transporter signature motif; other site
859657008361	Walker B; other site
859657008362	D-loop; other site
859657008363	H-loop/switch region; other site
859657008364	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859657008365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657008366	dimer interface [polypeptide binding]; other site
859657008367	conserved gate region; other site
859657008368	putative PBP binding loops; other site
859657008369	ABC-ATPase subunit interface; other site
859657008370	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859657008371	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657008372	substrate binding pocket [chemical binding]; other site
859657008373	membrane-bound complex binding site; other site
859657008374	hinge residues; other site
859657008375	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
859657008376	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657008377	putative DNA binding site [nucleotide binding]; other site
859657008378	putative Zn2+ binding site [ion binding]; other site
859657008379	AsnC family; Region: AsnC_trans_reg; pfam01037
859657008380	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
859657008381	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
859657008382	dimer interface [polypeptide binding]; other site
859657008383	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
859657008384	active site
859657008385	Fe binding site [ion binding]; other site
859657008386	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
859657008387	homotrimer interaction site [polypeptide binding]; other site
859657008388	putative active site [active]
859657008389	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
859657008390	Predicted membrane protein [Function unknown]; Region: COG2119
859657008391	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
859657008392	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
859657008393	guanine deaminase; Provisional; Region: PRK09228
859657008394	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
859657008395	active site
859657008396	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
859657008397	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
859657008398	active site
859657008399	purine riboside binding site [chemical binding]; other site
859657008400	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
859657008401	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
859657008402	XdhC Rossmann domain; Region: XdhC_C; pfam13478
859657008403	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
859657008404	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
859657008405	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859657008406	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
859657008407	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657008408	catalytic loop [active]
859657008409	iron binding site [ion binding]; other site
859657008410	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
859657008411	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
859657008412	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657008413	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657008414	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463
859657008415	putative substrate binding pocket [chemical binding]; other site
859657008416	putative dimerization interface [polypeptide binding]; other site
859657008417	PBP superfamily domain; Region: PBP_like_2; pfam12849
859657008418	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
859657008419	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
859657008420	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657008421	Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910
859657008422	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
859657008423	FtsX-like permease family; Region: FtsX; pfam02687
859657008424	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
859657008425	apolar tunnel; other site
859657008426	heme binding site [chemical binding]; other site
859657008427	dimerization interface [polypeptide binding]; other site
859657008428	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
859657008429	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
859657008430	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657008431	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657008432	Bacterial transcriptional repressor; Region: TetR; pfam13972
859657008433	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
859657008434	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
859657008435	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859657008436	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859657008437	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
859657008438	putative active site [active]
859657008439	putative metal binding site [ion binding]; other site
859657008440	PGAP1-like protein; Region: PGAP1; pfam07819
859657008441	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657008442	RDD family; Region: RDD; pfam06271
859657008443	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
859657008444	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
859657008445	RNA polymerase factor sigma-70; Validated; Region: PRK09047
859657008446	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657008447	DNA binding residues [nucleotide binding]
859657008448	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
859657008449	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
859657008450	PYR/PP interface [polypeptide binding]; other site
859657008451	dimer interface [polypeptide binding]; other site
859657008452	TPP binding site [chemical binding]; other site
859657008453	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
859657008454	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
859657008455	TPP-binding site [chemical binding]; other site
859657008456	dimer interface [polypeptide binding]; other site
859657008457	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
859657008458	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
859657008459	putative valine binding site [chemical binding]; other site
859657008460	dimer interface [polypeptide binding]; other site
859657008461	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
859657008462	ketol-acid reductoisomerase; Provisional; Region: PRK05479
859657008463	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
859657008464	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
859657008465	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
859657008466	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
859657008467	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
859657008468	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
859657008469	2-isopropylmalate synthase; Validated; Region: PRK00915
859657008470	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
859657008471	active site
859657008472	catalytic residues [active]
859657008473	metal binding site [ion binding]; metal-binding site
859657008474	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
859657008475	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859657008476	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
859657008477	putative ligand binding site [chemical binding]; other site
859657008478	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
859657008479	16S/18S rRNA binding site [nucleotide binding]; other site
859657008480	S13e-L30e interaction site [polypeptide binding]; other site
859657008481	25S rRNA binding site [nucleotide binding]; other site
859657008482	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
859657008483	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
859657008484	RNase E interface [polypeptide binding]; other site
859657008485	trimer interface [polypeptide binding]; other site
859657008486	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
859657008487	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
859657008488	RNase E interface [polypeptide binding]; other site
859657008489	trimer interface [polypeptide binding]; other site
859657008490	active site
859657008491	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
859657008492	putative nucleic acid binding region [nucleotide binding]; other site
859657008493	G-X-X-G motif; other site
859657008494	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
859657008495	RNA binding site [nucleotide binding]; other site
859657008496	domain interface; other site
859657008497	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
859657008498	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
859657008499	NAD(P) binding site [chemical binding]; other site
859657008500	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
859657008501	triosephosphate isomerase; Provisional; Region: PRK14567
859657008502	substrate binding site [chemical binding]; other site
859657008503	dimer interface [polypeptide binding]; other site
859657008504	catalytic triad [active]
859657008505	Preprotein translocase SecG subunit; Region: SecG; pfam03840
859657008506	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
859657008507	NADH dehydrogenase subunit B; Validated; Region: PRK06411
859657008508	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
859657008509	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
859657008510	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
859657008511	NADH dehydrogenase subunit D; Validated; Region: PRK06075
859657008512	NADH dehydrogenase subunit E; Validated; Region: PRK07539
859657008513	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
859657008514	putative dimer interface [polypeptide binding]; other site
859657008515	[2Fe-2S] cluster binding site [ion binding]; other site
859657008516	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
859657008517	SLBB domain; Region: SLBB; pfam10531
859657008518	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
859657008519	NADH dehydrogenase subunit G; Validated; Region: PRK09129
859657008520	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657008521	catalytic loop [active]
859657008522	iron binding site [ion binding]; other site
859657008523	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
859657008524	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
859657008525	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
859657008526	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
859657008527	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
859657008528	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
859657008529	4Fe-4S binding domain; Region: Fer4; cl02805
859657008530	4Fe-4S binding domain; Region: Fer4; pfam00037
859657008531	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
859657008532	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
859657008533	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
859657008534	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
859657008535	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
859657008536	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
859657008537	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
859657008538	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
859657008539	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
859657008540	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
859657008541	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
859657008542	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
859657008543	dimer interface [polypeptide binding]; other site
859657008544	ADP-ribose binding site [chemical binding]; other site
859657008545	active site
859657008546	nudix motif; other site
859657008547	metal binding site [ion binding]; metal-binding site
859657008548	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
859657008549	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
859657008550	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
859657008551	FAD binding site [chemical binding]; other site
859657008552	substrate binding site [chemical binding]; other site
859657008553	catalytic base [active]
859657008554	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
859657008555	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
859657008556	active site
859657008557	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
859657008558	putative active site [active]
859657008559	putative catalytic site [active]
859657008560	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
859657008561	putative active site [active]
859657008562	putative catalytic site [active]
859657008563	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859657008564	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
859657008565	putative ligand binding site [chemical binding]; other site
859657008566	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859657008567	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859657008568	TM-ABC transporter signature motif; other site
859657008569	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859657008570	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859657008571	TM-ABC transporter signature motif; other site
859657008572	Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674
859657008573	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859657008574	Walker A/P-loop; other site
859657008575	ATP binding site [chemical binding]; other site
859657008576	Q-loop/lid; other site
859657008577	ABC transporter signature motif; other site
859657008578	Walker B; other site
859657008579	D-loop; other site
859657008580	H-loop/switch region; other site
859657008581	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
859657008582	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859657008583	Walker A/P-loop; other site
859657008584	ATP binding site [chemical binding]; other site
859657008585	Q-loop/lid; other site
859657008586	ABC transporter signature motif; other site
859657008587	Walker B; other site
859657008588	D-loop; other site
859657008589	H-loop/switch region; other site
859657008590	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
859657008591	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
859657008592	alpha-gamma subunit interface [polypeptide binding]; other site
859657008593	beta-gamma subunit interface [polypeptide binding]; other site
859657008594	Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370
859657008595	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
859657008596	gamma-beta subunit interface [polypeptide binding]; other site
859657008597	alpha-beta subunit interface [polypeptide binding]; other site
859657008598	urease subunit alpha; Reviewed; Region: ureC; PRK13207
859657008599	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
859657008600	subunit interactions [polypeptide binding]; other site
859657008601	active site
859657008602	flap region; other site
859657008603	urease accessory protein UreE; Provisional; Region: ureE; PRK13263
859657008604	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
859657008605	dimer interface [polypeptide binding]; other site
859657008606	catalytic residues [active]
859657008607	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
859657008608	UreF; Region: UreF; pfam01730
859657008609	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
859657008610	G1 box; other site
859657008611	GTP/Mg2+ binding site [chemical binding]; other site
859657008612	G2 box; other site
859657008613	Switch I region; other site
859657008614	G3 box; other site
859657008615	Switch II region; other site
859657008616	G4 box; other site
859657008617	G5 box; other site
859657008618	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
859657008619	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
859657008620	putative di-iron ligands [ion binding]; other site
859657008621	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
859657008622	Lysine efflux permease [General function prediction only]; Region: COG1279
859657008623	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
859657008624	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
859657008625	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
859657008626	C-terminal domain interface [polypeptide binding]; other site
859657008627	GSH binding site (G-site) [chemical binding]; other site
859657008628	dimer interface [polypeptide binding]; other site
859657008629	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
859657008630	N-terminal domain interface [polypeptide binding]; other site
859657008631	putative dimer interface [polypeptide binding]; other site
859657008632	active site
859657008633	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859657008634	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
859657008635	FAD binding site [chemical binding]; other site
859657008636	substrate binding site [chemical binding]; other site
859657008637	catalytic base [active]
859657008638	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
859657008639	CoenzymeA binding site [chemical binding]; other site
859657008640	subunit interaction site [polypeptide binding]; other site
859657008641	PHB binding site; other site
859657008642	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
859657008643	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657008644	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
859657008645	substrate binding pocket [chemical binding]; other site
859657008646	dimerization interface [polypeptide binding]; other site
859657008647	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657008648	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657008649	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657008650	putative effector binding pocket; other site
859657008651	dimerization interface [polypeptide binding]; other site
859657008652	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
859657008653	dimer interface [polypeptide binding]; other site
859657008654	putative metal binding site [ion binding]; other site
859657008655	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
859657008656	Phosphotransferase enzyme family; Region: APH; pfam01636
859657008657	putative active site [active]
859657008658	putative substrate binding site [chemical binding]; other site
859657008659	ATP binding site [chemical binding]; other site
859657008660	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
859657008661	catalytic core [active]
859657008662	enoyl-CoA hydratase; Provisional; Region: PRK07511
859657008663	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657008664	substrate binding site [chemical binding]; other site
859657008665	oxyanion hole (OAH) forming residues; other site
859657008666	trimer interface [polypeptide binding]; other site
859657008667	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
859657008668	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
859657008669	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
859657008670	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
859657008671	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859657008672	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
859657008673	C-terminal domain interface [polypeptide binding]; other site
859657008674	GSH binding site (G-site) [chemical binding]; other site
859657008675	dimer interface [polypeptide binding]; other site
859657008676	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
859657008677	putative N-terminal domain interface [polypeptide binding]; other site
859657008678	putative dimer interface [polypeptide binding]; other site
859657008679	putative substrate binding pocket (H-site) [chemical binding]; other site
859657008680	methionine aminotransferase; Validated; Region: PRK09082
859657008681	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657008682	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657008683	homodimer interface [polypeptide binding]; other site
859657008684	catalytic residue [active]
859657008685	PIN domain; Region: PIN_3; pfam13470
859657008686	hypothetical protein; Validated; Region: PRK02101
859657008687	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
859657008688	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
859657008689	putative active site [active]
859657008690	Zn binding site [ion binding]; other site
859657008691	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
859657008692	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
859657008693	Protein of unknown function (DUF2863); Region: DUF2863; pfam11062
859657008694	aconitate hydratase; Provisional; Region: acnA; PRK12881
859657008695	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
859657008696	substrate binding site [chemical binding]; other site
859657008697	ligand binding site [chemical binding]; other site
859657008698	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
859657008699	substrate binding site [chemical binding]; other site
859657008700	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
859657008701	2-methylcitrate dehydratase; Region: prpD; TIGR02330
859657008702	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
859657008703	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
859657008704	dimer interface [polypeptide binding]; other site
859657008705	active site
859657008706	citrylCoA binding site [chemical binding]; other site
859657008707	oxalacetate/citrate binding site [chemical binding]; other site
859657008708	coenzyme A binding site [chemical binding]; other site
859657008709	catalytic triad [active]
859657008710	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
859657008711	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
859657008712	tetramer interface [polypeptide binding]; other site
859657008713	active site
859657008714	Mg2+/Mn2+ binding site [ion binding]; other site
859657008715	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
859657008716	malate dehydrogenase; Provisional; Region: PRK05442
859657008717	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
859657008718	NAD(P) binding site [chemical binding]; other site
859657008719	dimer interface [polypeptide binding]; other site
859657008720	malate binding site [chemical binding]; other site
859657008721	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
859657008722	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657008723	DNA-binding site [nucleotide binding]; DNA binding site
859657008724	UTRA domain; Region: UTRA; pfam07702
859657008725	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
859657008726	Iron-sulfur protein interface; other site
859657008727	proximal quinone binding site [chemical binding]; other site
859657008728	SdhD (CybS) interface [polypeptide binding]; other site
859657008729	proximal heme binding site [chemical binding]; other site
859657008730	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
859657008731	SdhC subunit interface [polypeptide binding]; other site
859657008732	proximal heme binding site [chemical binding]; other site
859657008733	cardiolipin binding site; other site
859657008734	Iron-sulfur protein interface; other site
859657008735	proximal quinone binding site [chemical binding]; other site
859657008736	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
859657008737	L-aspartate oxidase; Provisional; Region: PRK06175
859657008738	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
859657008739	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
859657008740	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
859657008741	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
859657008742	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
859657008743	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
859657008744	dimer interface [polypeptide binding]; other site
859657008745	active site
859657008746	citrylCoA binding site [chemical binding]; other site
859657008747	NADH binding [chemical binding]; other site
859657008748	cationic pore residues; other site
859657008749	oxalacetate/citrate binding site [chemical binding]; other site
859657008750	coenzyme A binding site [chemical binding]; other site
859657008751	catalytic triad [active]
859657008752	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
859657008753	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
859657008754	substrate binding site [chemical binding]; other site
859657008755	ligand binding site [chemical binding]; other site
859657008756	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
859657008757	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
859657008758	substrate binding site [chemical binding]; other site
859657008759	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
859657008760	tartrate dehydrogenase; Region: TTC; TIGR02089
859657008761	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
859657008762	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
859657008763	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
859657008764	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859657008765	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
859657008766	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
859657008767	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
859657008768	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
859657008769	dimerization interface 3.5A [polypeptide binding]; other site
859657008770	active site
859657008771	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
859657008772	active site
859657008773	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
859657008774	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
859657008775	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657008776	catalytic residue [active]
859657008777	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
859657008778	DNA methylase; Region: N6_N4_Mtase; pfam01555
859657008779	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
859657008780	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
859657008781	substrate binding site [chemical binding]; other site
859657008782	active site
859657008783	catalytic residues [active]
859657008784	heterodimer interface [polypeptide binding]; other site
859657008785	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
859657008786	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
859657008787	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
859657008788	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
859657008789	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
859657008790	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
859657008791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
859657008792	Sporulation related domain; Region: SPOR; pfam05036
859657008793	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
859657008794	Colicin V production protein; Region: Colicin_V; pfam02674
859657008795	amidophosphoribosyltransferase; Provisional; Region: PRK09246
859657008796	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
859657008797	active site
859657008798	tetramer interface [polypeptide binding]; other site
859657008799	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859657008800	active site
859657008801	ABC-2 type transporter; Region: ABC2_membrane; cl17235
859657008802	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
859657008803	nodulation ABC transporter NodI; Provisional; Region: PRK13537
859657008804	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
859657008805	Walker A/P-loop; other site
859657008806	ATP binding site [chemical binding]; other site
859657008807	Q-loop/lid; other site
859657008808	ABC transporter signature motif; other site
859657008809	Walker B; other site
859657008810	D-loop; other site
859657008811	H-loop/switch region; other site
859657008812	phasin family protein; Region: phasin; TIGR01841
859657008813	Uncharacterized conserved protein [Function unknown]; Region: COG1434
859657008814	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
859657008815	putative active site [active]
859657008816	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
859657008817	Hemin uptake protein hemP; Region: hemP; cl10043
859657008818	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
859657008819	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
859657008820	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
859657008821	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
859657008822	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
859657008823	Evidence 4 : Homologs of previously reported genes of unknown function
859657008824	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
859657008825	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657008826	Walker A motif; other site
859657008827	ATP binding site [chemical binding]; other site
859657008828	Walker B motif; other site
859657008829	arginine finger; other site
859657008830	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657008831	Walker A motif; other site
859657008832	ATP binding site [chemical binding]; other site
859657008833	Walker B motif; other site
859657008834	arginine finger; other site
859657008835	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657008836	dimerization interface [polypeptide binding]; other site
859657008837	putative DNA binding site [nucleotide binding]; other site
859657008838	putative Zn2+ binding site [ion binding]; other site
859657008839	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
859657008840	putative hydrophobic ligand binding site [chemical binding]; other site
859657008841	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900
859657008842	putative hydrophobic ligand binding site [chemical binding]; other site
859657008843	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
859657008844	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
859657008845	glutamate racemase; Provisional; Region: PRK00865
859657008846	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
859657008847	Fumarase C-terminus; Region: Fumerase_C; pfam05683
859657008848	hypothetical protein; Provisional; Region: PRK05208
859657008849	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859657008850	EamA-like transporter family; Region: EamA; pfam00892
859657008851	EamA-like transporter family; Region: EamA; pfam00892
859657008852	acetyl-CoA synthetase; Provisional; Region: PRK00174
859657008853	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
859657008854	active site
859657008855	CoA binding site [chemical binding]; other site
859657008856	acyl-activating enzyme (AAE) consensus motif; other site
859657008857	AMP binding site [chemical binding]; other site
859657008858	acetate binding site [chemical binding]; other site
859657008859	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
859657008860	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
859657008861	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859657008862	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657008863	non-specific DNA binding site [nucleotide binding]; other site
859657008864	salt bridge; other site
859657008865	sequence-specific DNA binding site [nucleotide binding]; other site
859657008866	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
859657008867	DNA-binding interface [nucleotide binding]; DNA binding site
859657008868	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859657008869	HTH-like domain; Region: HTH_21; pfam13276
859657008870	Integrase core domain; Region: rve; pfam00665
859657008871	Integrase core domain; Region: rve_3; pfam13683
859657008872	Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin
859657008873	baseplate wedge subunit; Provisional; Region: W; PHA02516
859657008874	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
859657008875	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
859657008876	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
859657008877	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
859657008878	Evidence 7 : Gene remnant; Product type h : extrachromosomal origin
859657008879	Evidence 7 : Gene remnant; Product type h : extrachromosomal origin
859657008880	Evidence 7 : Gene remnant; Product type h : extrachromosomal origin
859657008881	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657008882	Coenzyme A binding pocket [chemical binding]; other site
859657008883	transcriptional regulator EpsA; Region: EpsA; TIGR03020
859657008884	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657008885	DNA binding residues [nucleotide binding]
859657008886	dimerization interface [polypeptide binding]; other site
859657008887	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859657008888	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
859657008889	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657008890	dimer interface [polypeptide binding]; other site
859657008891	putative CheW interface [polypeptide binding]; other site
859657008892	Cache domain; Region: Cache_1; pfam02743
859657008893	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657008894	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657008895	metal binding site [ion binding]; metal-binding site
859657008896	active site
859657008897	I-site; other site
859657008898	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657008899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657008900	active site
859657008901	phosphorylation site [posttranslational modification]
859657008902	dimerization interface [polypeptide binding]; other site
859657008903	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657008904	DNA binding site [nucleotide binding]
859657008905	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
859657008906	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657008907	catalytic loop [active]
859657008908	iron binding site [ion binding]; other site
859657008909	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
859657008910	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
859657008911	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859657008912	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
859657008913	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859657008914	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859657008915	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
859657008916	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
859657008917	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
859657008918	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
859657008919	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
859657008920	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
859657008921	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
859657008922	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
859657008923	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
859657008924	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859657008925	Walker A/P-loop; other site
859657008926	ATP binding site [chemical binding]; other site
859657008927	Q-loop/lid; other site
859657008928	ABC transporter signature motif; other site
859657008929	Walker B; other site
859657008930	D-loop; other site
859657008931	H-loop/switch region; other site
859657008932	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
859657008933	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
859657008934	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859657008935	Walker A/P-loop; other site
859657008936	ATP binding site [chemical binding]; other site
859657008937	Q-loop/lid; other site
859657008938	ABC transporter signature motif; other site
859657008939	Walker B; other site
859657008940	D-loop; other site
859657008941	H-loop/switch region; other site
859657008942	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
859657008943	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
859657008944	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657008945	dimer interface [polypeptide binding]; other site
859657008946	conserved gate region; other site
859657008947	putative PBP binding loops; other site
859657008948	ABC-ATPase subunit interface; other site
859657008949	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
859657008950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657008951	dimer interface [polypeptide binding]; other site
859657008952	conserved gate region; other site
859657008953	putative PBP binding loops; other site
859657008954	ABC-ATPase subunit interface; other site
859657008955	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
859657008956	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
859657008957	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657008958	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657008959	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657008960	dimerization interface [polypeptide binding]; other site
859657008961	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657008962	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
859657008963	putative ligand binding site [chemical binding]; other site
859657008964	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
859657008965	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
859657008966	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
859657008967	nudix motif; other site
859657008968	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
859657008969	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
859657008970	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
859657008971	putative active site [active]
859657008972	putative substrate binding site [chemical binding]; other site
859657008973	putative cosubstrate binding site; other site
859657008974	catalytic site [active]
859657008975	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
859657008976	active site
859657008977	catalytic site [active]
859657008978	substrate binding site [chemical binding]; other site
859657008979	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
859657008980	Transposase; Region: HTH_Tnp_1; pfam01527
859657008981	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859657008982	HTH-like domain; Region: HTH_21; pfam13276
859657008983	Integrase core domain; Region: rve; pfam00665
859657008984	Integrase core domain; Region: rve_3; pfam13683
859657008985	transcriptional activator TtdR; Provisional; Region: PRK09801
859657008986	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657008987	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
859657008988	putative effector binding pocket; other site
859657008989	putative dimerization interface [polypeptide binding]; other site
859657008990	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
859657008991	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
859657008992	putative active site pocket [active]
859657008993	metal binding site [ion binding]; metal-binding site
859657008994	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
859657008995	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
859657008996	malic enzyme; Reviewed; Region: PRK12862
859657008997	Malic enzyme, N-terminal domain; Region: malic; pfam00390
859657008998	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
859657008999	putative NAD(P) binding site [chemical binding]; other site
859657009000	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
859657009001	Transposase; Region: HTH_Tnp_1; cl17663
859657009002	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
859657009003	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
859657009004	Integrase core domain; Region: rve; pfam00665
859657009005	Integrase core domain; Region: rve_3; pfam13683
859657009006	Restriction endonuclease; Region: Mrr_cat; pfam04471
859657009007	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
859657009008	catalytic core [active]
859657009009	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
859657009010	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
859657009011	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
859657009012	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859657009013	Ligand Binding Site [chemical binding]; other site
859657009014	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
859657009015	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
859657009016	putative NAD(P) binding site [chemical binding]; other site
859657009017	putative substrate binding site [chemical binding]; other site
859657009018	catalytic Zn binding site [ion binding]; other site
859657009019	structural Zn binding site [ion binding]; other site
859657009020	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
859657009021	FOG: CBS domain [General function prediction only]; Region: COG0517
859657009022	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
859657009023	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859657009024	Ligand Binding Site [chemical binding]; other site
859657009025	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859657009026	Ligand Binding Site [chemical binding]; other site
859657009027	Flavodoxins [Energy production and conversion]; Region: FldA; COG0716
859657009028	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
859657009029	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
859657009030	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
859657009031	BON domain; Region: BON; pfam04972
859657009032	BON domain; Region: BON; pfam04972
859657009033	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
859657009034	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
859657009035	ligand binding site [chemical binding]; other site
859657009036	flexible hinge region; other site
859657009037	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
859657009038	putative switch regulator; other site
859657009039	non-specific DNA interactions [nucleotide binding]; other site
859657009040	DNA binding site [nucleotide binding]
859657009041	sequence specific DNA binding site [nucleotide binding]; other site
859657009042	putative cAMP binding site [chemical binding]; other site
859657009043	PAS domain S-box; Region: sensory_box; TIGR00229
859657009044	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657009045	putative active site [active]
859657009046	heme pocket [chemical binding]; other site
859657009047	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657009048	Histidine kinase; Region: HisKA_3; pfam07730
859657009049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657009050	ATP binding site [chemical binding]; other site
859657009051	Mg2+ binding site [ion binding]; other site
859657009052	G-X-G motif; other site
859657009053	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657009054	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657009055	active site
859657009056	phosphorylation site [posttranslational modification]
859657009057	intermolecular recognition site; other site
859657009058	dimerization interface [polypeptide binding]; other site
859657009059	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657009060	DNA binding residues [nucleotide binding]
859657009061	dimerization interface [polypeptide binding]; other site
859657009062	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
859657009063	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
859657009064	putative dimer interface [polypeptide binding]; other site
859657009065	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
859657009066	RNA/DNA hybrid binding site [nucleotide binding]; other site
859657009067	active site
859657009068	Methyltransferase domain; Region: Methyltransf_11; pfam08241
859657009069	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
859657009070	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
859657009071	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859657009072	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859657009073	catalytic residue [active]
859657009074	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859657009075	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
859657009076	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657009077	acyl-activating enzyme (AAE) consensus motif; other site
859657009078	AMP binding site [chemical binding]; other site
859657009079	active site
859657009080	CoA binding site [chemical binding]; other site
859657009081	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
859657009082	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
859657009083	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
859657009084	catalytic site [active]
859657009085	subunit interface [polypeptide binding]; other site
859657009086	leucine export protein LeuE; Provisional; Region: PRK10958
859657009087	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
859657009088	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
859657009089	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
859657009090	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
859657009091	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
859657009092	ATP-grasp domain; Region: ATP-grasp_4; cl17255
859657009093	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
859657009094	IMP binding site; other site
859657009095	dimer interface [polypeptide binding]; other site
859657009096	interdomain contacts; other site
859657009097	partial ornithine binding site; other site
859657009098	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
859657009099	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
859657009100	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
859657009101	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
859657009102	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
859657009103	FtsJ-like methyltransferase; Region: FtsJ; cl17430
859657009104	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
859657009105	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
859657009106	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657009107	Walker A motif; other site
859657009108	ATP binding site [chemical binding]; other site
859657009109	Walker B motif; other site
859657009110	arginine finger; other site
859657009111	Peptidase family M41; Region: Peptidase_M41; pfam01434
859657009112	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
859657009113	dihydropteroate synthase; Region: DHPS; TIGR01496
859657009114	substrate binding pocket [chemical binding]; other site
859657009115	dimer interface [polypeptide binding]; other site
859657009116	inhibitor binding site; inhibition site
859657009117	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
859657009118	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
859657009119	active site
859657009120	substrate binding site [chemical binding]; other site
859657009121	metal binding site [ion binding]; metal-binding site
859657009122	PBP superfamily domain; Region: PBP_like_2; cl17296
859657009123	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
859657009124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657009125	dimer interface [polypeptide binding]; other site
859657009126	conserved gate region; other site
859657009127	putative PBP binding loops; other site
859657009128	ABC-ATPase subunit interface; other site
859657009129	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
859657009130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657009131	dimer interface [polypeptide binding]; other site
859657009132	conserved gate region; other site
859657009133	putative PBP binding loops; other site
859657009134	ABC-ATPase subunit interface; other site
859657009135	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
859657009136	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
859657009137	Walker A/P-loop; other site
859657009138	ATP binding site [chemical binding]; other site
859657009139	Q-loop/lid; other site
859657009140	ABC transporter signature motif; other site
859657009141	Walker B; other site
859657009142	D-loop; other site
859657009143	H-loop/switch region; other site
859657009144	transcriptional regulator PhoU; Provisional; Region: PRK11115
859657009145	PhoU domain; Region: PhoU; pfam01895
859657009146	PhoU domain; Region: PhoU; pfam01895
859657009147	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
859657009148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657009149	active site
859657009150	phosphorylation site [posttranslational modification]
859657009151	intermolecular recognition site; other site
859657009152	dimerization interface [polypeptide binding]; other site
859657009153	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657009154	DNA binding site [nucleotide binding]
859657009155	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
859657009156	PAS domain; Region: PAS; smart00091
859657009157	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657009158	dimer interface [polypeptide binding]; other site
859657009159	phosphorylation site [posttranslational modification]
859657009160	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657009161	ATP binding site [chemical binding]; other site
859657009162	Mg2+ binding site [ion binding]; other site
859657009163	G-X-G motif; other site
859657009164	polyphosphate kinase 1; Region: poly_P_kin; TIGR03705
859657009165	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
859657009166	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
859657009167	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
859657009168	putative domain interface [polypeptide binding]; other site
859657009169	putative active site [active]
859657009170	catalytic site [active]
859657009171	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
859657009172	putative domain interface [polypeptide binding]; other site
859657009173	putative active site [active]
859657009174	catalytic site [active]
859657009175	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
859657009176	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
859657009177	Putative hemolysin [General function prediction only]; Region: COG3176
859657009178	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
859657009179	catalytic core [active]
859657009180	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
859657009181	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657009182	dimerization interface [polypeptide binding]; other site
859657009183	putative DNA binding site [nucleotide binding]; other site
859657009184	putative Zn2+ binding site [ion binding]; other site
859657009185	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
859657009186	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
859657009187	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657009188	metal binding site [ion binding]; metal-binding site
859657009189	active site
859657009190	I-site; other site
859657009191	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657009192	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859657009193	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
859657009194	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859657009195	catalytic residue [active]
859657009196	Cupin-like domain; Region: Cupin_8; pfam13621
859657009197	Uncharacterized conserved protein [Function unknown]; Region: COG1615
859657009198	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
859657009199	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
859657009200	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657009201	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657009202	dimerization interface [polypeptide binding]; other site
859657009203	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
859657009204	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657009205	dimer interface [polypeptide binding]; other site
859657009206	conserved gate region; other site
859657009207	putative PBP binding loops; other site
859657009208	ABC-ATPase subunit interface; other site
859657009209	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
859657009210	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
859657009211	Walker A/P-loop; other site
859657009212	ATP binding site [chemical binding]; other site
859657009213	Q-loop/lid; other site
859657009214	ABC transporter signature motif; other site
859657009215	Walker B; other site
859657009216	D-loop; other site
859657009217	H-loop/switch region; other site
859657009218	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
859657009219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657009220	dimer interface [polypeptide binding]; other site
859657009221	putative PBP binding loops; other site
859657009222	ABC-ATPase subunit interface; other site
859657009223	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
859657009224	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657009225	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657009226	trimer interface [polypeptide binding]; other site
859657009227	eyelet of channel; other site
859657009228	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
859657009229	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
859657009230	active site
859657009231	catalytic tetrad [active]
859657009232	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859657009233	active site
859657009234	Integrase core domain; Region: rve_3; cl15866
859657009235	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
859657009236	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657009237	putative substrate translocation pore; other site
859657009238	short chain dehydrogenase; Provisional; Region: PRK06179
859657009239	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
859657009240	NADP binding site [chemical binding]; other site
859657009241	active site
859657009242	steroid binding site; other site
859657009243	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
859657009244	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657009245	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657009246	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657009247	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657009248	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657009249	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859657009250	Transposase; Region: HTH_Tnp_Tc3_2; pfam01498
859657009251	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859657009252	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
859657009253	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859657009254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
859657009255	Transposase; Region: HTH_Tnp_1; pfam01527
859657009256	HTH-like domain; Region: HTH_21; pfam13276
859657009257	Integrase core domain; Region: rve; pfam00665
859657009258	DDE domain; Region: DDE_Tnp_IS240; pfam13610
859657009259	Integrase core domain; Region: rve_3; pfam13683
859657009260	Domain of unknown function (DUF1910); Region: DUF1910; pfam08928
859657009261	Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
859657009262	Evidence 4 : Homologs of previously reported genes of unknown function
859657009263	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
859657009264	replicative DNA helicase; Provisional; Region: PRK05973
859657009265	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
859657009266	active site
859657009267	DNA binding site [nucleotide binding]
859657009268	Int/Topo IB signature motif; other site
859657009269	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
859657009270	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
859657009271	Integrase core domain; Region: rve_3; cl15866
859657009272	IS2 transposase TnpB; Reviewed; Region: PRK09409
859657009273	Integrase core domain; Region: rve; pfam00665
859657009274	Transposase; Region: HTH_Tnp_1; cl17663
859657009275	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
859657009276	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
859657009277	multiple promoter invertase; Provisional; Region: mpi; PRK13413
859657009278	catalytic residues [active]
859657009279	catalytic nucleophile [active]
859657009280	Presynaptic Site I dimer interface [polypeptide binding]; other site
859657009281	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
859657009282	Synaptic Flat tetramer interface [polypeptide binding]; other site
859657009283	Synaptic Site I dimer interface [polypeptide binding]; other site
859657009284	DNA binding site [nucleotide binding]
859657009285	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
859657009286	DNA-binding interface [nucleotide binding]; DNA binding site
859657009287	Transposase; Region: HTH_Tnp_1; pfam01527
859657009288	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859657009289	HTH-like domain; Region: HTH_21; pfam13276
859657009290	Integrase core domain; Region: rve; pfam00665
859657009291	Integrase core domain; Region: rve_3; pfam13683
859657009292	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
859657009293	FAD binding domain; Region: FAD_binding_4; pfam01565
859657009294	Predicted membrane protein [Function unknown]; Region: COG3308
859657009295	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
859657009296	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859657009297	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
859657009298	Predicted membrane protein [Function unknown]; Region: COG4323
859657009299	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657009300	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
859657009301	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
859657009302	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
859657009303	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
859657009304	homodimer interface [polypeptide binding]; other site
859657009305	substrate-cofactor binding pocket; other site
859657009306	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657009307	catalytic residue [active]
859657009308	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625
859657009309	FOG: CBS domain [General function prediction only]; Region: COG0517
859657009310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657009311	putative substrate translocation pore; other site
859657009312	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
859657009313	putative acyl-acceptor binding pocket; other site
859657009314	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
859657009315	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
859657009316	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
859657009317	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
859657009318	Tetramer interface [polypeptide binding]; other site
859657009319	active site
859657009320	FMN-binding site [chemical binding]; other site
859657009321	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
859657009322	hydroxyglutarate oxidase; Provisional; Region: PRK11728
859657009323	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
859657009324	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
859657009325	short chain dehydrogenase; Provisional; Region: PRK06949
859657009326	classical (c) SDRs; Region: SDR_c; cd05233
859657009327	NAD(P) binding site [chemical binding]; other site
859657009328	active site
859657009329	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657009330	PAS domain; Region: PAS_9; pfam13426
859657009331	putative active site [active]
859657009332	heme pocket [chemical binding]; other site
859657009333	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657009334	DNA binding residues [nucleotide binding]
859657009335	dimerization interface [polypeptide binding]; other site
859657009336	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
859657009337	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
859657009338	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
859657009339	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657009340	NAD(P) binding site [chemical binding]; other site
859657009341	active site
859657009342	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
859657009343	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657009344	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
859657009345	homotrimer interaction site [polypeptide binding]; other site
859657009346	putative active site [active]
859657009347	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
859657009348	HD domain; Region: HD_4; pfam13328
859657009349	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
859657009350	synthetase active site [active]
859657009351	NTP binding site [chemical binding]; other site
859657009352	metal binding site [ion binding]; metal-binding site
859657009353	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
859657009354	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
859657009355	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
859657009356	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
859657009357	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
859657009358	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
859657009359	active site
859657009360	dimer interface [polypeptide binding]; other site
859657009361	motif 1; other site
859657009362	motif 2; other site
859657009363	motif 3; other site
859657009364	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
859657009365	anticodon binding site; other site
859657009366	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
859657009367	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
859657009368	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
859657009369	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
859657009370	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
859657009371	23S rRNA binding site [nucleotide binding]; other site
859657009372	L21 binding site [polypeptide binding]; other site
859657009373	L13 binding site [polypeptide binding]; other site
859657009374	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
859657009375	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
859657009376	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
859657009377	dimer interface [polypeptide binding]; other site
859657009378	motif 1; other site
859657009379	active site
859657009380	motif 2; other site
859657009381	motif 3; other site
859657009382	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
859657009383	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
859657009384	putative tRNA-binding site [nucleotide binding]; other site
859657009385	B3/4 domain; Region: B3_4; pfam03483
859657009386	tRNA synthetase B5 domain; Region: B5; smart00874
859657009387	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
859657009388	dimer interface [polypeptide binding]; other site
859657009389	motif 1; other site
859657009390	motif 3; other site
859657009391	motif 2; other site
859657009392	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
859657009393	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
859657009394	IHF dimer interface [polypeptide binding]; other site
859657009395	IHF - DNA interface [nucleotide binding]; other site
859657009396	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
859657009397	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
859657009398	DNA binding residues [nucleotide binding]
859657009399	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
859657009400	active site
859657009401	catalytic residues [active]
859657009402	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
859657009403	active site
859657009404	DNA polymerase IV; Validated; Region: PRK02406
859657009405	DNA binding site [nucleotide binding]
859657009406	amino acid transporter; Region: 2A0306; TIGR00909
859657009407	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
859657009408	Uncharacterized secreted protein [Function unknown]; Region: COG5429
859657009409	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
859657009410	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
859657009411	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
859657009412	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859657009413	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
859657009414	putative catalytic site [active]
859657009415	putative phosphate binding site [ion binding]; other site
859657009416	active site
859657009417	metal binding site A [ion binding]; metal-binding site
859657009418	DNA binding site [nucleotide binding]
859657009419	putative AP binding site [nucleotide binding]; other site
859657009420	putative metal binding site B [ion binding]; other site
859657009421	cytosine deaminase; Validated; Region: PRK07572
859657009422	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
859657009423	active site
859657009424	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
859657009425	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
859657009426	active site
859657009427	Zn binding site [ion binding]; other site
859657009428	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
859657009429	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
859657009430	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
859657009431	homodimer interface [polypeptide binding]; other site
859657009432	NADP binding site [chemical binding]; other site
859657009433	substrate binding site [chemical binding]; other site
859657009434	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
859657009435	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657009436	active site
859657009437	phosphorylation site [posttranslational modification]
859657009438	intermolecular recognition site; other site
859657009439	dimerization interface [polypeptide binding]; other site
859657009440	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657009441	DNA binding residues [nucleotide binding]
859657009442	dimerization interface [polypeptide binding]; other site
859657009443	PAS domain S-box; Region: sensory_box; TIGR00229
859657009444	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657009445	putative active site [active]
859657009446	heme pocket [chemical binding]; other site
859657009447	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
859657009448	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657009449	dimer interface [polypeptide binding]; other site
859657009450	phosphorylation site [posttranslational modification]
859657009451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657009452	ATP binding site [chemical binding]; other site
859657009453	Mg2+ binding site [ion binding]; other site
859657009454	G-X-G motif; other site
859657009455	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
859657009456	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
859657009457	dimer interface [polypeptide binding]; other site
859657009458	TPP-binding site [chemical binding]; other site
859657009459	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
859657009460	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
859657009461	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
859657009462	E3 interaction surface; other site
859657009463	lipoyl attachment site [posttranslational modification]; other site
859657009464	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
859657009465	E3 interaction surface; other site
859657009466	lipoyl attachment site [posttranslational modification]; other site
859657009467	e3 binding domain; Region: E3_binding; pfam02817
859657009468	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
859657009469	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
859657009470	active site
859657009471	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
859657009472	E3 interaction surface; other site
859657009473	lipoyl attachment site [posttranslational modification]; other site
859657009474	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
859657009475	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859657009476	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
859657009477	Phasin protein; Region: Phasin_2; pfam09361
859657009478	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
859657009479	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
859657009480	putative active site [active]
859657009481	Zn binding site [ion binding]; other site
859657009482	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859657009483	EamA-like transporter family; Region: EamA; pfam00892
859657009484	EamA-like transporter family; Region: EamA; pfam00892
859657009485	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
859657009486	active site
859657009487	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
859657009488	putative FMN binding site [chemical binding]; other site
859657009489	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
859657009490	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
859657009491	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859657009492	Transcriptional regulator [Transcription]; Region: IclR; COG1414
859657009493	Bacterial transcriptional regulator; Region: IclR; pfam01614
859657009494	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
859657009495	Cysteine-rich domain; Region: CCG; pfam02754
859657009496	Cysteine-rich domain; Region: CCG; pfam02754
859657009497	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
859657009498	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
859657009499	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
859657009500	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
859657009501	TM2 domain; Region: TM2; pfam05154
859657009502	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
859657009503	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
859657009504	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
859657009505	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
859657009506	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
859657009507	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
859657009508	nudix motif; other site
859657009509	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
859657009510	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
859657009511	quinone interaction residues [chemical binding]; other site
859657009512	active site
859657009513	catalytic residues [active]
859657009514	FMN binding site [chemical binding]; other site
859657009515	substrate binding site [chemical binding]; other site
859657009516	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
859657009517	potassium uptake protein; Region: kup; TIGR00794
859657009518	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
859657009519	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
859657009520	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
859657009521	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
859657009522	RNA binding site [nucleotide binding]; other site
859657009523	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
859657009524	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
859657009525	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
859657009526	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
859657009527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
859657009528	binding surface
859657009529	TPR motif; other site
859657009530	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
859657009531	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859657009532	RNA binding surface [nucleotide binding]; other site
859657009533	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
859657009534	active site
859657009535	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
859657009536	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
859657009537	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
859657009538	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
859657009539	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
859657009540	putative acyltransferase; Provisional; Region: PRK05790
859657009541	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859657009542	dimer interface [polypeptide binding]; other site
859657009543	active site
859657009544	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
859657009545	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
859657009546	NAD(P) binding site [chemical binding]; other site
859657009547	homotetramer interface [polypeptide binding]; other site
859657009548	homodimer interface [polypeptide binding]; other site
859657009549	active site
859657009550	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
859657009551	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
859657009552	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
859657009553	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
859657009554	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
859657009555	FMN binding site [chemical binding]; other site
859657009556	active site
859657009557	catalytic residues [active]
859657009558	substrate binding site [chemical binding]; other site
859657009559	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
859657009560	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
859657009561	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657009562	FeS/SAM binding site; other site
859657009563	TRAM domain; Region: TRAM; cl01282
859657009564	beta-ketothiolase; Provisional; Region: PRK09051
859657009565	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859657009566	dimer interface [polypeptide binding]; other site
859657009567	active site
859657009568	cystathionine beta-lyase; Provisional; Region: PRK07050
859657009569	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859657009570	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859657009571	catalytic residue [active]
859657009572	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
859657009573	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859657009574	motif II; other site
859657009575	acetylornithine deacetylase; Provisional; Region: PRK07522
859657009576	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
859657009577	metal binding site [ion binding]; metal-binding site
859657009578	putative dimer interface [polypeptide binding]; other site
859657009579	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
859657009580	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
859657009581	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859657009582	ATP binding site [chemical binding]; other site
859657009583	putative Mg++ binding site [ion binding]; other site
859657009584	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859657009585	nucleotide binding region [chemical binding]; other site
859657009586	ATP-binding site [chemical binding]; other site
859657009587	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
859657009588	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
859657009589	substrate binding site; other site
859657009590	dimer interface; other site
859657009591	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
859657009592	homotrimer interaction site [polypeptide binding]; other site
859657009593	zinc binding site [ion binding]; other site
859657009594	CDP-binding sites; other site
859657009595	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
859657009596	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
859657009597	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
859657009598	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
859657009599	dimer interface [polypeptide binding]; other site
859657009600	decamer (pentamer of dimers) interface [polypeptide binding]; other site
859657009601	catalytic triad [active]
859657009602	peroxidatic and resolving cysteines [active]
859657009603	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
859657009604	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657009605	dimerization interface [polypeptide binding]; other site
859657009606	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657009607	ATP binding site [chemical binding]; other site
859657009608	Mg2+ binding site [ion binding]; other site
859657009609	G-X-G motif; other site
859657009610	osmolarity response regulator; Provisional; Region: ompR; PRK09468
859657009611	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657009612	active site
859657009613	phosphorylation site [posttranslational modification]
859657009614	intermolecular recognition site; other site
859657009615	dimerization interface [polypeptide binding]; other site
859657009616	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657009617	DNA binding site [nucleotide binding]
859657009618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267
859657009619	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
859657009620	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
859657009621	active site lid residues [active]
859657009622	substrate binding pocket [chemical binding]; other site
859657009623	catalytic residues [active]
859657009624	substrate-Mg2+ binding site; other site
859657009625	aspartate-rich region 1; other site
859657009626	aspartate-rich region 2; other site
859657009627	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657009628	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657009629	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657009630	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859657009631	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
859657009632	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
859657009633	Uncharacterized conserved protein [Function unknown]; Region: COG4121
859657009634	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
859657009635	trigger factor; Provisional; Region: tig; PRK01490
859657009636	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
859657009637	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
859657009638	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
859657009639	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
859657009640	oligomer interface [polypeptide binding]; other site
859657009641	active site residues [active]
859657009642	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
859657009643	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
859657009644	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657009645	Walker A motif; other site
859657009646	ATP binding site [chemical binding]; other site
859657009647	Walker B motif; other site
859657009648	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
859657009649	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
859657009650	Found in ATP-dependent protease La (LON); Region: LON; smart00464
859657009651	Found in ATP-dependent protease La (LON); Region: LON; smart00464
859657009652	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657009653	Walker A motif; other site
859657009654	ATP binding site [chemical binding]; other site
859657009655	Walker B motif; other site
859657009656	arginine finger; other site
859657009657	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
859657009658	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
859657009659	IHF dimer interface [polypeptide binding]; other site
859657009660	IHF - DNA interface [nucleotide binding]; other site
859657009661	SurA N-terminal domain; Region: SurA_N_3; cl07813
859657009662	periplasmic folding chaperone; Provisional; Region: PRK10788
859657009663	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
859657009664	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
859657009665	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
859657009666	Catalytic site [active]
859657009667	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
859657009668	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
859657009669	active site
859657009670	catalytic triad [active]
859657009671	oxyanion hole [active]
859657009672	switch loop; other site
859657009673	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
859657009674	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
859657009675	Walker A/P-loop; other site
859657009676	ATP binding site [chemical binding]; other site
859657009677	Q-loop/lid; other site
859657009678	ABC transporter signature motif; other site
859657009679	Walker B; other site
859657009680	D-loop; other site
859657009681	H-loop/switch region; other site
859657009682	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
859657009683	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
859657009684	active site
859657009685	dimer interface [polypeptide binding]; other site
859657009686	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
859657009687	dimer interface [polypeptide binding]; other site
859657009688	active site
859657009689	putative carbohydrate kinase; Provisional; Region: PRK10565
859657009690	Uncharacterized conserved protein [Function unknown]; Region: COG0062
859657009691	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
859657009692	putative substrate binding site [chemical binding]; other site
859657009693	putative ATP binding site [chemical binding]; other site
859657009694	Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631
859657009695	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
859657009696	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
859657009697	dimerization interface [polypeptide binding]; other site
859657009698	ATP binding site [chemical binding]; other site
859657009699	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
859657009700	dimerization interface [polypeptide binding]; other site
859657009701	ATP binding site [chemical binding]; other site
859657009702	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
859657009703	putative active site [active]
859657009704	catalytic triad [active]
859657009705	Evidence 4 : Homologs of previously reported genes of unknown function
859657009706	Domain of unknown function (DUF1842); Region: DUF1842; pfam08896
859657009707	Domain of unknown function (DUF1843); Region: DUF1843; pfam08898
859657009708	Domain of unknown function (DUF1842); Region: DUF1842; pfam08896
859657009709	Domain of unknown function (DUF1843); Region: DUF1843; pfam08898
859657009710	Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913
859657009711	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657009712	FeS/SAM binding site; other site
859657009713	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
859657009714	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657009715	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657009716	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
859657009717	putative effector binding pocket; other site
859657009718	putative dimerization interface [polypeptide binding]; other site
859657009719	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
859657009720	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657009721	NAD(P) binding site [chemical binding]; other site
859657009722	active site
859657009723	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
859657009724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657009725	dimer interface [polypeptide binding]; other site
859657009726	conserved gate region; other site
859657009727	putative PBP binding loops; other site
859657009728	ABC-ATPase subunit interface; other site
859657009729	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657009730	dimer interface [polypeptide binding]; other site
859657009731	conserved gate region; other site
859657009732	putative PBP binding loops; other site
859657009733	ABC-ATPase subunit interface; other site
859657009734	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
859657009735	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
859657009736	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
859657009737	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657009738	Walker A/P-loop; other site
859657009739	ATP binding site [chemical binding]; other site
859657009740	Q-loop/lid; other site
859657009741	ABC transporter signature motif; other site
859657009742	Walker B; other site
859657009743	D-loop; other site
859657009744	H-loop/switch region; other site
859657009745	TOBE domain; Region: TOBE_2; pfam08402
859657009746	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
859657009747	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657009748	dimer interface [polypeptide binding]; other site
859657009749	phosphorylation site [posttranslational modification]
859657009750	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657009751	ATP binding site [chemical binding]; other site
859657009752	Mg2+ binding site [ion binding]; other site
859657009753	G-X-G motif; other site
859657009754	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
859657009755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657009756	active site
859657009757	phosphorylation site [posttranslational modification]
859657009758	intermolecular recognition site; other site
859657009759	dimerization interface [polypeptide binding]; other site
859657009760	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657009761	DNA binding site [nucleotide binding]
859657009762	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657009763	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657009764	trimer interface [polypeptide binding]; other site
859657009765	eyelet of channel; other site
859657009766	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
859657009767	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657009768	Walker A/P-loop; other site
859657009769	ATP binding site [chemical binding]; other site
859657009770	Q-loop/lid; other site
859657009771	ABC transporter signature motif; other site
859657009772	Walker B; other site
859657009773	D-loop; other site
859657009774	H-loop/switch region; other site
859657009775	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859657009776	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
859657009777	TM-ABC transporter signature motif; other site
859657009778	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
859657009779	zinc binding site [ion binding]; other site
859657009780	putative ligand binding site [chemical binding]; other site
859657009781	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
859657009782	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
859657009783	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
859657009784	intracellular septation protein A; Reviewed; Region: PRK00259
859657009785	methionine sulfoxide reductase B; Provisional; Region: PRK00222
859657009786	SelR domain; Region: SelR; pfam01641
859657009787	Uncharacterized conserved protein [Function unknown]; Region: COG0397
859657009788	hypothetical protein; Validated; Region: PRK00029
859657009789	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
859657009790	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
859657009791	dimer interface [polypeptide binding]; other site
859657009792	acyl-activating enzyme (AAE) consensus motif; other site
859657009793	putative active site [active]
859657009794	AMP binding site [chemical binding]; other site
859657009795	putative CoA binding site [chemical binding]; other site
859657009796	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859657009797	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
859657009798	putative ligand binding site [chemical binding]; other site
859657009799	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859657009800	TM-ABC transporter signature motif; other site
859657009801	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859657009802	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859657009803	TM-ABC transporter signature motif; other site
859657009804	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859657009805	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859657009806	Walker A/P-loop; other site
859657009807	ATP binding site [chemical binding]; other site
859657009808	Q-loop/lid; other site
859657009809	ABC transporter signature motif; other site
859657009810	Walker B; other site
859657009811	D-loop; other site
859657009812	H-loop/switch region; other site
859657009813	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859657009814	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859657009815	Walker A/P-loop; other site
859657009816	ATP binding site [chemical binding]; other site
859657009817	Q-loop/lid; other site
859657009818	ABC transporter signature motif; other site
859657009819	Walker B; other site
859657009820	D-loop; other site
859657009821	H-loop/switch region; other site
859657009822	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
859657009823	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
859657009824	lysine transporter; Provisional; Region: PRK10836
859657009825	lysine transporter; Provisional; Region: PRK10836
859657009826	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657009827	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
859657009828	substrate binding site [chemical binding]; other site
859657009829	oxyanion hole (OAH) forming residues; other site
859657009830	trimer interface [polypeptide binding]; other site
859657009831	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
859657009832	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
859657009833	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
859657009834	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
859657009835	Isochorismatase family; Region: Isochorismatase; pfam00857
859657009836	catalytic triad [active]
859657009837	metal binding site [ion binding]; metal-binding site
859657009838	conserved cis-peptide bond; other site
859657009839	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
859657009840	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859657009841	dimer interface [polypeptide binding]; other site
859657009842	active site
859657009843	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859657009844	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859657009845	active site
859657009846	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
859657009847	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
859657009848	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657009849	NAD(P) binding site [chemical binding]; other site
859657009850	active site
859657009851	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
859657009852	CoenzymeA binding site [chemical binding]; other site
859657009853	subunit interaction site [polypeptide binding]; other site
859657009854	PHB binding site; other site
859657009855	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
859657009856	Beta-lactamase; Region: Beta-lactamase; pfam00144
859657009857	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
859657009858	Prostaglandin dehydrogenases; Region: PGDH; cd05288
859657009859	NAD(P) binding site [chemical binding]; other site
859657009860	substrate binding site [chemical binding]; other site
859657009861	dimer interface [polypeptide binding]; other site
859657009862	hypothetical protein; Provisional; Region: PRK06208
859657009863	intersubunit interface [polypeptide binding]; other site
859657009864	active site
859657009865	Zn2+ binding site [ion binding]; other site
859657009866	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859657009867	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
859657009868	C-terminal domain interface [polypeptide binding]; other site
859657009869	GSH binding site (G-site) [chemical binding]; other site
859657009870	dimer interface [polypeptide binding]; other site
859657009871	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
859657009872	substrate binding pocket (H-site) [chemical binding]; other site
859657009873	N-terminal domain interface [polypeptide binding]; other site
859657009874	hypothetical protein; Provisional; Region: PRK06194
859657009875	classical (c) SDRs; Region: SDR_c; cd05233
859657009876	NAD(P) binding site [chemical binding]; other site
859657009877	active site
859657009878	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859657009879	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
859657009880	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
859657009881	putative active site [active]
859657009882	metal binding site [ion binding]; metal-binding site
859657009883	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
859657009884	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
859657009885	substrate binding pocket [chemical binding]; other site
859657009886	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
859657009887	active site
859657009888	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
859657009889	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657009890	Coenzyme A binding pocket [chemical binding]; other site
859657009891	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
859657009892	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
859657009893	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657009894	Uncharacterized conserved protein [Function unknown]; Region: COG3332
859657009895	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
859657009896	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
859657009897	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
859657009898	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
859657009899	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
859657009900	dimerization interface [polypeptide binding]; other site
859657009901	thymidylate kinase; Validated; Region: tmk; PRK00698
859657009902	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
859657009903	TMP-binding site; other site
859657009904	ATP-binding site [chemical binding]; other site
859657009905	DNA polymerase III subunit delta'; Validated; Region: PRK06964
859657009906	DNA polymerase III subunit delta'; Validated; Region: PRK08485
859657009907	PilZ domain; Region: PilZ; cl01260
859657009908	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
859657009909	active site
859657009910	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657009911	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859657009912	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859657009913	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657009914	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
859657009915	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
859657009916	Transcriptional regulators [Transcription]; Region: PurR; COG1609
859657009917	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859657009918	DNA binding site [nucleotide binding]
859657009919	domain linker motif; other site
859657009920	Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282
859657009921	putative dimerization interface [polypeptide binding]; other site
859657009922	putative ligand binding site [chemical binding]; other site
859657009923	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
859657009924	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
859657009925	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
859657009926	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657009927	dimer interface [polypeptide binding]; other site
859657009928	conserved gate region; other site
859657009929	putative PBP binding loops; other site
859657009930	ABC-ATPase subunit interface; other site
859657009931	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
859657009932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657009933	dimer interface [polypeptide binding]; other site
859657009934	conserved gate region; other site
859657009935	putative PBP binding loops; other site
859657009936	ABC-ATPase subunit interface; other site
859657009937	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
859657009938	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657009939	Walker A/P-loop; other site
859657009940	ATP binding site [chemical binding]; other site
859657009941	Q-loop/lid; other site
859657009942	ABC transporter signature motif; other site
859657009943	Walker B; other site
859657009944	D-loop; other site
859657009945	H-loop/switch region; other site
859657009946	TOBE domain; Region: TOBE_2; pfam08402
859657009947	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
859657009948	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
859657009949	active site
859657009950	metal binding site [ion binding]; metal-binding site
859657009951	hexamer interface [polypeptide binding]; other site
859657009952	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
859657009953	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
859657009954	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
859657009955	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859657009956	putative C-terminal domain interface [polypeptide binding]; other site
859657009957	putative GSH binding site (G-site) [chemical binding]; other site
859657009958	putative dimer interface [polypeptide binding]; other site
859657009959	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
859657009960	putative N-terminal domain interface [polypeptide binding]; other site
859657009961	putative dimer interface [polypeptide binding]; other site
859657009962	putative substrate binding pocket (H-site) [chemical binding]; other site
859657009963	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
859657009964	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
859657009965	tetramer interface [polypeptide binding]; other site
859657009966	TPP-binding site [chemical binding]; other site
859657009967	heterodimer interface [polypeptide binding]; other site
859657009968	phosphorylation loop region [posttranslational modification]
859657009969	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
859657009970	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
859657009971	alpha subunit interface [polypeptide binding]; other site
859657009972	TPP binding site [chemical binding]; other site
859657009973	heterodimer interface [polypeptide binding]; other site
859657009974	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
859657009975	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
859657009976	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
859657009977	E3 interaction surface; other site
859657009978	lipoyl attachment site [posttranslational modification]; other site
859657009979	e3 binding domain; Region: E3_binding; pfam02817
859657009980	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
859657009981	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype
859657009982	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657009983	Leucine-rich repeats; other site
859657009984	Substrate binding site [chemical binding]; other site
859657009985	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657009986	Leucine-rich repeats; other site
859657009987	Substrate binding site [chemical binding]; other site
859657009988	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
859657009989	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
859657009990	conserved cys residue [active]
859657009991	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657009992	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657009993	benzoate transport; Region: 2A0115; TIGR00895
859657009994	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657009995	putative substrate translocation pore; other site
859657009996	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657009997	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
859657009998	hypothetical protein; Validated; Region: PRK09169
859657009999	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
859657010000	metal binding triad [ion binding]; metal-binding site
859657010001	hypothetical protein; Validated; Region: PRK09169
859657010002	Protein of unknown function (DUF687); Region: DUF687; pfam05095
859657010003	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
859657010004	metal binding triad [ion binding]; metal-binding site
859657010005	Integrase core domain; Region: rve; pfam00665
859657010006	Integrase core domain; Region: rve_3; pfam13683
859657010007	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
859657010008	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
859657010009	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859657010010	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859657010011	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859657010012	catalytic residue [active]
859657010013	catalytic residue [active]
859657010014	High potential iron-sulfur protein; Region: HIPIP; pfam01355
859657010015	Integrase core domain; Region: rve; pfam00665
859657010016	Protein kinase domain; Region: Pkinase; pfam00069
859657010017	Catalytic domain of Protein Kinases; Region: PKc; cd00180
859657010018	active site
859657010019	ATP binding site [chemical binding]; other site
859657010020	substrate binding site [chemical binding]; other site
859657010021	activation loop (A-loop); other site
859657010022	Homeodomain-like domain; Region: HTH_23; pfam13384
859657010023	Winged helix-turn helix; Region: HTH_29; pfam13551
859657010024	Homeodomain-like domain; Region: HTH_32; pfam13565
859657010025	Integrase core domain; Region: rve; pfam00665
859657010026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657010027	BT1 family; Region: BT1; pfam03092
859657010028	putative substrate translocation pore; other site
859657010029	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859657010030	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657010031	Condensation domain; Region: Condensation; pfam00668
859657010032	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859657010033	Nonribosomal peptide synthase; Region: NRPS; pfam08415
859657010034	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
859657010035	acyl-activating enzyme (AAE) consensus motif; other site
859657010036	AMP binding site [chemical binding]; other site
859657010037	Methyltransferase domain; Region: Methyltransf_12; pfam08242
859657010038	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657010039	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657010040	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
859657010041	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657010042	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
859657010043	active site
859657010044	Methyltransferase domain; Region: Methyltransf_12; pfam08242
859657010045	Methyltransferase domain; Region: Methyltransf_23; pfam13489
859657010046	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
859657010047	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859657010048	NADP binding site [chemical binding]; other site
859657010049	active site
859657010050	Condensation domain; Region: Condensation; pfam00668
859657010051	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
859657010052	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
859657010053	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657010054	Walker A/P-loop; other site
859657010055	ATP binding site [chemical binding]; other site
859657010056	Q-loop/lid; other site
859657010057	ABC transporter signature motif; other site
859657010058	Walker B; other site
859657010059	D-loop; other site
859657010060	H-loop/switch region; other site
859657010061	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
859657010062	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
859657010063	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657010064	Walker A/P-loop; other site
859657010065	ATP binding site [chemical binding]; other site
859657010066	Q-loop/lid; other site
859657010067	ABC transporter signature motif; other site
859657010068	Walker B; other site
859657010069	D-loop; other site
859657010070	H-loop/switch region; other site
859657010071	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859657010072	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859657010073	N-terminal plug; other site
859657010074	ligand-binding site [chemical binding]; other site
859657010075	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
859657010076	acyl-CoA synthetase; Validated; Region: PRK05850
859657010077	acyl-activating enzyme (AAE) consensus motif; other site
859657010078	active site
859657010079	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859657010080	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
859657010081	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859657010082	active site
859657010083	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
859657010084	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
859657010085	KR domain; Region: KR; pfam08659
859657010086	NADP binding site [chemical binding]; other site
859657010087	active site
859657010088	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657010089	Condensation domain; Region: Condensation; pfam00668
859657010090	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859657010091	Nonribosomal peptide synthase; Region: NRPS; pfam08415
859657010092	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
859657010093	acyl-activating enzyme (AAE) consensus motif; other site
859657010094	AMP binding site [chemical binding]; other site
859657010095	Methyltransferase domain; Region: Methyltransf_12; pfam08242
859657010096	Methyltransferase domain; Region: Methyltransf_23; pfam13489
859657010097	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657010098	Condensation domain; Region: Condensation; pfam00668
859657010099	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859657010100	Nonribosomal peptide synthase; Region: NRPS; pfam08415
859657010101	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859657010102	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859657010103	Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693
859657010104	Methyltransferase domain; Region: Methyltransf_11; pfam08241
859657010105	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
859657010106	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
859657010107	Protein of unknown function (DUF1653); Region: DUF1653; cl01949
859657010108	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
859657010109	AAA domain; Region: AAA_26; pfam13500
859657010110	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
859657010111	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
859657010112	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859657010113	catalytic residue [active]
859657010114	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
859657010115	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859657010116	inhibitor-cofactor binding pocket; inhibition site
859657010117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657010118	catalytic residue [active]
859657010119	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
859657010120	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
859657010121	putative NAD(P) binding site [chemical binding]; other site
859657010122	active site
859657010123	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
859657010124	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657010125	catalytic loop [active]
859657010126	iron binding site [ion binding]; other site
859657010127	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
859657010128	FAD binding pocket [chemical binding]; other site
859657010129	FAD binding motif [chemical binding]; other site
859657010130	phosphate binding motif [ion binding]; other site
859657010131	beta-alpha-beta structure motif; other site
859657010132	NAD binding pocket [chemical binding]; other site
859657010133	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
859657010134	inter-subunit interface; other site
859657010135	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
859657010136	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
859657010137	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
859657010138	putative alpha subunit interface [polypeptide binding]; other site
859657010139	putative active site [active]
859657010140	putative substrate binding site [chemical binding]; other site
859657010141	Fe binding site [ion binding]; other site
859657010142	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
859657010143	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
859657010144	dimer interface [polypeptide binding]; other site
859657010145	active site
859657010146	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
859657010147	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
859657010148	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
859657010149	octamer interface [polypeptide binding]; other site
859657010150	active site
859657010151	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657010152	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657010153	dimerization interface [polypeptide binding]; other site
859657010154	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
859657010155	Transglycosylase; Region: Transgly; cl17702
859657010156	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
859657010157	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
859657010158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657010159	putative substrate translocation pore; other site
859657010160	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657010161	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657010162	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657010163	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657010164	putative effector binding pocket; other site
859657010165	dimerization interface [polypeptide binding]; other site
859657010166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
859657010167	CreA protein; Region: CreA; pfam05981
859657010168	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
859657010169	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
859657010170	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
859657010171	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
859657010172	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859657010173	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
859657010174	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
859657010175	MoxR-like ATPases [General function prediction only]; Region: COG0714
859657010176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657010177	Walker A motif; other site
859657010178	ATP binding site [chemical binding]; other site
859657010179	Walker B motif; other site
859657010180	arginine finger; other site
859657010181	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
859657010182	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
859657010183	metal ion-dependent adhesion site (MIDAS); other site
859657010184	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
859657010185	putative hydrophobic ligand binding site [chemical binding]; other site
859657010186	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
859657010187	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
859657010188	XdhC Rossmann domain; Region: XdhC_C; pfam13478
859657010189	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
859657010190	fatty acyl CoA reductases (FARs), extended (e) SDRs; Region: FAR-N_SDR_e; cd05236
859657010191	putative NAD(P) binding site [chemical binding]; other site
859657010192	active site
859657010193	putative substrate binding site [chemical binding]; other site
859657010194	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
859657010195	MgtC family; Region: MgtC; pfam02308
859657010196	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859657010197	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
859657010198	dimer interface [polypeptide binding]; other site
859657010199	ligand binding site [chemical binding]; other site
859657010200	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657010201	dimerization interface [polypeptide binding]; other site
859657010202	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657010203	dimer interface [polypeptide binding]; other site
859657010204	putative CheW interface [polypeptide binding]; other site
859657010205	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
859657010206	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
859657010207	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
859657010208	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
859657010209	Predicted Fe-S protein [General function prediction only]; Region: COG3313
859657010210	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
859657010211	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859657010212	NAD binding site [chemical binding]; other site
859657010213	catalytic residues [active]
859657010214	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
859657010215	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859657010216	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859657010217	ABC transporter; Region: ABC_tran_2; pfam12848
859657010218	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859657010219	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
859657010220	dimer interface [polypeptide binding]; other site
859657010221	catalytic triad [active]
859657010222	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
859657010223	nucleoside/Zn binding site; other site
859657010224	dimer interface [polypeptide binding]; other site
859657010225	catalytic motif [active]
859657010226	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
859657010227	active site
859657010228	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
859657010229	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657010230	FeS/SAM binding site; other site
859657010231	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657010232	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859657010233	non-specific DNA binding site [nucleotide binding]; other site
859657010234	salt bridge; other site
859657010235	sequence-specific DNA binding site [nucleotide binding]; other site
859657010236	HipA N-terminal domain; Region: couple_hipA; TIGR03071
859657010237	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
859657010238	HipA-like N-terminal domain; Region: HipA_N; pfam07805
859657010239	HipA-like C-terminal domain; Region: HipA_C; pfam07804
859657010240	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657010241	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859657010242	putative substrate translocation pore; other site
859657010243	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
859657010244	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
859657010245	catalytic residues [active]
859657010246	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
859657010247	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
859657010248	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
859657010249	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
859657010250	heterodimer interface [polypeptide binding]; other site
859657010251	active site
859657010252	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
859657010253	heterodimer interface [polypeptide binding]; other site
859657010254	multimer interface [polypeptide binding]; other site
859657010255	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
859657010256	active site
859657010257	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
859657010258	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657010259	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
859657010260	putative dimerization interface [polypeptide binding]; other site
859657010261	GMP synthase; Reviewed; Region: guaA; PRK00074
859657010262	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
859657010263	AMP/PPi binding site [chemical binding]; other site
859657010264	candidate oxyanion hole; other site
859657010265	catalytic triad [active]
859657010266	potential glutamine specificity residues [chemical binding]; other site
859657010267	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
859657010268	ATP Binding subdomain [chemical binding]; other site
859657010269	Ligand Binding sites [chemical binding]; other site
859657010270	Dimerization subdomain; other site
859657010271	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
859657010272	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
859657010273	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
859657010274	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
859657010275	active site
859657010276	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859657010277	RnfH family Ubiquitin; Region: Ub-RnfH; cl17382
859657010278	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
859657010279	putative coenzyme Q binding site [chemical binding]; other site
859657010280	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
859657010281	SmpB-tmRNA interface; other site
859657010282	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
859657010283	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
859657010284	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
859657010285	phosphoenolpyruvate synthase; Validated; Region: PRK06464
859657010286	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
859657010287	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
859657010288	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
859657010289	PEP synthetase regulatory protein; Provisional; Region: PRK05339
859657010290	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
859657010291	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
859657010292	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
859657010293	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
859657010294	RNA/DNA hybrid binding site [nucleotide binding]; other site
859657010295	active site
859657010296	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
859657010297	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
859657010298	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
859657010299	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
859657010300	active site
859657010301	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
859657010302	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
859657010303	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
859657010304	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
859657010305	trimer interface [polypeptide binding]; other site
859657010306	active site
859657010307	UDP-GlcNAc binding site [chemical binding]; other site
859657010308	lipid binding site [chemical binding]; lipid-binding site
859657010309	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
859657010310	periplasmic chaperone; Provisional; Region: PRK10780
859657010311	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
859657010312	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
859657010313	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
859657010314	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
859657010315	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
859657010316	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
859657010317	Surface antigen; Region: Bac_surface_Ag; pfam01103
859657010318	zinc metallopeptidase RseP; Provisional; Region: PRK10779
859657010319	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
859657010320	active site
859657010321	putative substrate binding region [chemical binding]; other site
859657010322	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
859657010323	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
859657010324	putative substrate binding region [chemical binding]; other site
859657010325	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
859657010326	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
859657010327	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
859657010328	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
859657010329	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
859657010330	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
859657010331	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
859657010332	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
859657010333	catalytic residue [active]
859657010334	putative FPP diphosphate  binding site; other site
859657010335	putative FPP binding hydrophobic cleft; other site
859657010336	dimer interface [polypeptide binding]; other site
859657010337	putative IPP diphosphate binding site; other site
859657010338	ribosome recycling factor; Reviewed; Region: frr; PRK00083
859657010339	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
859657010340	hinge region; other site
859657010341	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
859657010342	putative nucleotide binding site [chemical binding]; other site
859657010343	uridine monophosphate binding site [chemical binding]; other site
859657010344	homohexameric interface [polypeptide binding]; other site
859657010345	elongation factor Ts; Provisional; Region: tsf; PRK09377
859657010346	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
859657010347	Elongation factor TS; Region: EF_TS; pfam00889
859657010348	Elongation factor TS; Region: EF_TS; pfam00889
859657010349	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
859657010350	rRNA interaction site [nucleotide binding]; other site
859657010351	S8 interaction site; other site
859657010352	putative laminin-1 binding site; other site
859657010353	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
859657010354	active site
859657010355	PII uridylyl-transferase; Provisional; Region: PRK03059
859657010356	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
859657010357	metal binding triad; other site
859657010358	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
859657010359	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859657010360	Zn2+ binding site [ion binding]; other site
859657010361	Mg2+ binding site [ion binding]; other site
859657010362	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
859657010363	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
859657010364	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
859657010365	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859657010366	RNA binding surface [nucleotide binding]; other site
859657010367	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
859657010368	active site
859657010369	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
859657010370	active site
859657010371	catalytic residues [active]
859657010372	metal binding site [ion binding]; metal-binding site
859657010373	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
859657010374	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
859657010375	nucleotide binding pocket [chemical binding]; other site
859657010376	K-X-D-G motif; other site
859657010377	catalytic site [active]
859657010378	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
859657010379	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
859657010380	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
859657010381	Dimer interface [polypeptide binding]; other site
859657010382	BRCT sequence motif; other site
859657010383	ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771
859657010384	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
859657010385	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
859657010386	Walker A/P-loop; other site
859657010387	ATP binding site [chemical binding]; other site
859657010388	Q-loop/lid; other site
859657010389	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
859657010390	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
859657010391	Q-loop/lid; other site
859657010392	ABC transporter signature motif; other site
859657010393	Walker B; other site
859657010394	D-loop; other site
859657010395	H-loop/switch region; other site
859657010396	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
859657010397	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657010398	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859657010399	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
859657010400	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657010401	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657010402	homodimer interface [polypeptide binding]; other site
859657010403	catalytic residue [active]
859657010404	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
859657010405	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
859657010406	trimer interface [polypeptide binding]; other site
859657010407	active site
859657010408	substrate binding site [chemical binding]; other site
859657010409	CoA binding site [chemical binding]; other site
859657010410	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
859657010411	ArsC family; Region: ArsC; pfam03960
859657010412	putative catalytic residues [active]
859657010413	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
859657010414	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
859657010415	metal binding site [ion binding]; metal-binding site
859657010416	dimer interface [polypeptide binding]; other site
859657010417	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
859657010418	putative active site [active]
859657010419	putative metal binding residues [ion binding]; other site
859657010420	signature motif; other site
859657010421	putative triphosphate binding site [ion binding]; other site
859657010422	dimer interface [polypeptide binding]; other site
859657010423	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
859657010424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657010425	S-adenosylmethionine binding site [chemical binding]; other site
859657010426	Outer membrane efflux protein; Region: OEP; pfam02321
859657010427	Outer membrane efflux protein; Region: OEP; pfam02321
859657010428	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
859657010429	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657010430	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859657010431	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
859657010432	SxDxEG motif; other site
859657010433	active site
859657010434	metal binding site [ion binding]; metal-binding site
859657010435	homopentamer interface [polypeptide binding]; other site
859657010436	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
859657010437	homodimer interface [polypeptide binding]; other site
859657010438	homotetramer interface [polypeptide binding]; other site
859657010439	active site pocket [active]
859657010440	cleavage site
859657010441	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
859657010442	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
859657010443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657010444	dimer interface [polypeptide binding]; other site
859657010445	conserved gate region; other site
859657010446	putative PBP binding loops; other site
859657010447	ABC-ATPase subunit interface; other site
859657010448	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
859657010449	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657010450	dimer interface [polypeptide binding]; other site
859657010451	conserved gate region; other site
859657010452	putative PBP binding loops; other site
859657010453	ABC-ATPase subunit interface; other site
859657010454	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
859657010455	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
859657010456	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
859657010457	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859657010458	Walker A/P-loop; other site
859657010459	ATP binding site [chemical binding]; other site
859657010460	Q-loop/lid; other site
859657010461	ABC transporter signature motif; other site
859657010462	Walker B; other site
859657010463	D-loop; other site
859657010464	H-loop/switch region; other site
859657010465	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
859657010466	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859657010467	Walker A/P-loop; other site
859657010468	ATP binding site [chemical binding]; other site
859657010469	Q-loop/lid; other site
859657010470	ABC transporter signature motif; other site
859657010471	Walker B; other site
859657010472	D-loop; other site
859657010473	H-loop/switch region; other site
859657010474	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
859657010475	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
859657010476	catalytic nucleophile [active]
859657010477	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
859657010478	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
859657010479	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
859657010480	putative active site [active]
859657010481	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
859657010482	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859657010483	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859657010484	ABC transporter; Region: ABC_tran_2; pfam12848
859657010485	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859657010486	formyl-coenzyme A transferase; Provisional; Region: PRK05398
859657010487	CoA-transferase family III; Region: CoA_transf_3; pfam02515
859657010488	Evidence 4 : Homologs of previously reported genes of unknown function
859657010489	disulfide bond formation protein B; Provisional; Region: PRK02110
859657010490	DNA repair protein RadA; Provisional; Region: PRK11823
859657010491	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
859657010492	Walker A motif/ATP binding site; other site
859657010493	ATP binding site [chemical binding]; other site
859657010494	Walker B motif; other site
859657010495	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
859657010496	alanine racemase; Reviewed; Region: alr; PRK00053
859657010497	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
859657010498	active site
859657010499	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859657010500	substrate binding site [chemical binding]; other site
859657010501	catalytic residues [active]
859657010502	dimer interface [polypeptide binding]; other site
859657010503	lysophospholipid transporter LplT; Provisional; Region: PRK11195
859657010504	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
859657010505	Fe-S cluster binding site [ion binding]; other site
859657010506	active site
859657010507	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
859657010508	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
859657010509	Glycoprotease family; Region: Peptidase_M22; pfam00814
859657010510	Acyl-CoA-binding protein [Lipid metabolism]; Region: ACB; COG4281
859657010511	acyl-CoA binding pocket [chemical binding]; other site
859657010512	CoA binding site [chemical binding]; other site
859657010513	DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863
859657010514	putative hydrophobic ligand binding site [chemical binding]; other site
859657010515	malate synthase A; Region: malate_syn_A; TIGR01344
859657010516	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
859657010517	active site
859657010518	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
859657010519	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859657010520	motif II; other site
859657010521	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657010522	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657010523	putative effector binding pocket; other site
859657010524	dimerization interface [polypeptide binding]; other site
859657010525	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859657010526	Ligand Binding Site [chemical binding]; other site
859657010527	isocitrate lyase; Provisional; Region: PRK15063
859657010528	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
859657010529	tetramer interface [polypeptide binding]; other site
859657010530	active site
859657010531	Mg2+/Mn2+ binding site [ion binding]; other site
859657010532	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
859657010533	Leucine rich repeat; Region: LRR_8; pfam13855
859657010534	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657010535	Leucine-rich repeats; other site
859657010536	Substrate binding site [chemical binding]; other site
859657010537	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657010538	Leucine-rich repeats; other site
859657010539	Substrate binding site [chemical binding]; other site
859657010540	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859657010541	Leucine rich repeat; Region: LRR_8; pfam13855
859657010542	Leucine-rich repeats; other site
859657010543	Substrate binding site [chemical binding]; other site
859657010544	Leucine rich repeat; Region: LRR_8; pfam13855
859657010545	Leucine rich repeat; Region: LRR_8; pfam13855
859657010546	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
859657010547	putative active site pocket [active]
859657010548	dimerization interface [polypeptide binding]; other site
859657010549	putative catalytic residue [active]
859657010550	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
859657010551	thiamine pyrophosphate protein; Validated; Region: PRK08199
859657010552	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
859657010553	PYR/PP interface [polypeptide binding]; other site
859657010554	dimer interface [polypeptide binding]; other site
859657010555	TPP binding site [chemical binding]; other site
859657010556	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
859657010557	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
859657010558	TPP-binding site [chemical binding]; other site
859657010559	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
859657010560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657010561	active site
859657010562	phosphorylation site [posttranslational modification]
859657010563	intermolecular recognition site; other site
859657010564	dimerization interface [polypeptide binding]; other site
859657010565	LytTr DNA-binding domain; Region: LytTR; smart00850
859657010566	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
859657010567	Histidine kinase; Region: His_kinase; pfam06580
859657010568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657010569	ATP binding site [chemical binding]; other site
859657010570	Mg2+ binding site [ion binding]; other site
859657010571	G-X-G motif; other site
859657010572	2TM domain; Region: 2TM; pfam13239
859657010573	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
859657010574	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657010575	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
859657010576	substrate binding site [chemical binding]; other site
859657010577	dimerization interface [polypeptide binding]; other site
859657010578	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
859657010579	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
859657010580	Walker A/P-loop; other site
859657010581	ATP binding site [chemical binding]; other site
859657010582	Q-loop/lid; other site
859657010583	ABC transporter signature motif; other site
859657010584	Walker B; other site
859657010585	D-loop; other site
859657010586	H-loop/switch region; other site
859657010587	TOBE-like domain; Region: TOBE_3; pfam12857
859657010588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657010589	dimer interface [polypeptide binding]; other site
859657010590	conserved gate region; other site
859657010591	putative PBP binding loops; other site
859657010592	ABC-ATPase subunit interface; other site
859657010593	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
859657010594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657010595	dimer interface [polypeptide binding]; other site
859657010596	conserved gate region; other site
859657010597	putative PBP binding loops; other site
859657010598	ABC-ATPase subunit interface; other site
859657010599	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
859657010600	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657010601	EAL domain; Region: EAL; pfam00563
859657010602	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
859657010603	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
859657010604	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
859657010605	Walker A/P-loop; other site
859657010606	ATP binding site [chemical binding]; other site
859657010607	Q-loop/lid; other site
859657010608	ABC transporter signature motif; other site
859657010609	Walker B; other site
859657010610	D-loop; other site
859657010611	H-loop/switch region; other site
859657010612	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
859657010613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657010614	putative PBP binding loops; other site
859657010615	ABC-ATPase subunit interface; other site
859657010616	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
859657010617	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
859657010618	active site
859657010619	dimer interface [polypeptide binding]; other site
859657010620	non-prolyl cis peptide bond; other site
859657010621	insertion regions; other site
859657010622	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657010623	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
859657010624	dimerization interface [polypeptide binding]; other site
859657010625	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657010626	substrate binding pocket [chemical binding]; other site
859657010627	membrane-bound complex binding site; other site
859657010628	hinge residues; other site
859657010629	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859657010630	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
859657010631	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
859657010632	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
859657010633	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
859657010634	Clp amino terminal domain; Region: Clp_N; pfam02861
859657010635	Clp amino terminal domain; Region: Clp_N; pfam02861
859657010636	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657010637	Walker A motif; other site
859657010638	ATP binding site [chemical binding]; other site
859657010639	Walker B motif; other site
859657010640	arginine finger; other site
859657010641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657010642	Walker A motif; other site
859657010643	ATP binding site [chemical binding]; other site
859657010644	Walker B motif; other site
859657010645	arginine finger; other site
859657010646	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
859657010647	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
859657010648	chromosome condensation membrane protein; Provisional; Region: PRK14196
859657010649	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
859657010650	MoaE homodimer interface [polypeptide binding]; other site
859657010651	MoaD interaction [polypeptide binding]; other site
859657010652	active site residues [active]
859657010653	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
859657010654	MoaE interaction surface [polypeptide binding]; other site
859657010655	MoeB interaction surface [polypeptide binding]; other site
859657010656	thiocarboxylated glycine; other site
859657010657	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
859657010658	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
859657010659	dimer interface [polypeptide binding]; other site
859657010660	putative functional site; other site
859657010661	putative MPT binding site; other site
859657010662	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
859657010663	putative uracil binding site [chemical binding]; other site
859657010664	putative active site [active]
859657010665	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
859657010666	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
859657010667	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657010668	catalytic residue [active]
859657010669	homoserine dehydrogenase; Provisional; Region: PRK06349
859657010670	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
859657010671	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
859657010672	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
859657010673	aminotransferase AlaT; Validated; Region: PRK09265
859657010674	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657010675	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657010676	homodimer interface [polypeptide binding]; other site
859657010677	catalytic residue [active]
859657010678	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
859657010679	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
859657010680	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
859657010681	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
859657010682	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
859657010683	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
859657010684	inhibitor-cofactor binding pocket; inhibition site
859657010685	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657010686	catalytic residue [active]
859657010687	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
859657010688	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
859657010689	Ligand binding site; other site
859657010690	Putative Catalytic site; other site
859657010691	DXD motif; other site
859657010692	putative formyltransferase; Provisional; Region: PRK06988
859657010693	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
859657010694	active site
859657010695	substrate binding site [chemical binding]; other site
859657010696	cosubstrate binding site; other site
859657010697	catalytic site [active]
859657010698	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
859657010699	active site
859657010700	NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908
859657010701	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
859657010702	NAD binding site [chemical binding]; other site
859657010703	substrate binding site [chemical binding]; other site
859657010704	active site
859657010705	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
859657010706	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
859657010707	putative active site [active]
859657010708	putative catalytic site [active]
859657010709	putative Zn binding site [ion binding]; other site
859657010710	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
859657010711	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859657010712	catalytic triad [active]
859657010713	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
859657010714	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
859657010715	putative active site [active]
859657010716	PhoH-like protein; Region: PhoH; pfam02562
859657010717	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
859657010718	NlpC/P60 family; Region: NLPC_P60; pfam00877
859657010719	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
859657010720	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
859657010721	replicative DNA helicase; Provisional; Region: PRK07004
859657010722	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
859657010723	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
859657010724	Walker A motif; other site
859657010725	ATP binding site [chemical binding]; other site
859657010726	Walker B motif; other site
859657010727	DNA binding loops [nucleotide binding]
859657010728	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
859657010729	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
859657010730	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
859657010731	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
859657010732	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
859657010733	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
859657010734	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
859657010735	active site
859657010736	homotetramer interface [polypeptide binding]; other site
859657010737	homodimer interface [polypeptide binding]; other site
859657010738	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
859657010739	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
859657010740	FAD binding pocket [chemical binding]; other site
859657010741	FAD binding motif [chemical binding]; other site
859657010742	phosphate binding motif [ion binding]; other site
859657010743	beta-alpha-beta structure motif; other site
859657010744	NAD binding pocket [chemical binding]; other site
859657010745	LexA repressor; Validated; Region: PRK00215
859657010746	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
859657010747	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
859657010748	Catalytic site [active]
859657010749	hypothetical protein; Provisional; Region: PRK06156
859657010750	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
859657010751	active site
859657010752	metal binding site [ion binding]; metal-binding site
859657010753	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
859657010754	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
859657010755	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
859657010756	FMN binding site [chemical binding]; other site
859657010757	active site
859657010758	catalytic residues [active]
859657010759	substrate binding site [chemical binding]; other site
859657010760	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
859657010761	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657010762	substrate binding site [chemical binding]; other site
859657010763	oxyanion hole (OAH) forming residues; other site
859657010764	trimer interface [polypeptide binding]; other site
859657010765	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
859657010766	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
859657010767	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
859657010768	G1 box; other site
859657010769	putative GEF interaction site [polypeptide binding]; other site
859657010770	GTP/Mg2+ binding site [chemical binding]; other site
859657010771	Switch I region; other site
859657010772	G2 box; other site
859657010773	G3 box; other site
859657010774	Switch II region; other site
859657010775	G4 box; other site
859657010776	G5 box; other site
859657010777	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
859657010778	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
859657010779	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859657010780	MarR family; Region: MarR; pfam01047
859657010781	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859657010782	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
859657010783	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657010784	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657010785	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
859657010786	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657010787	putative substrate translocation pore; other site
859657010788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657010789	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
859657010790	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
859657010791	RNA binding site [nucleotide binding]; other site
859657010792	active site
859657010793	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
859657010794	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
859657010795	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
859657010796	translation initiation factor IF-2; Region: IF-2; TIGR00487
859657010797	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
859657010798	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
859657010799	G1 box; other site
859657010800	putative GEF interaction site [polypeptide binding]; other site
859657010801	GTP/Mg2+ binding site [chemical binding]; other site
859657010802	Switch I region; other site
859657010803	G2 box; other site
859657010804	G3 box; other site
859657010805	Switch II region; other site
859657010806	G4 box; other site
859657010807	G5 box; other site
859657010808	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
859657010809	Translation-initiation factor 2; Region: IF-2; pfam11987
859657010810	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
859657010811	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
859657010812	NusA N-terminal domain; Region: NusA_N; pfam08529
859657010813	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
859657010814	RNA binding site [nucleotide binding]; other site
859657010815	homodimer interface [polypeptide binding]; other site
859657010816	NusA-like KH domain; Region: KH_5; pfam13184
859657010817	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
859657010818	G-X-X-G motif; other site
859657010819	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
859657010820	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
859657010821	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
859657010822	Sm and related proteins; Region: Sm_like; cl00259
859657010823	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
859657010824	putative oligomer interface [polypeptide binding]; other site
859657010825	putative RNA binding site [nucleotide binding]; other site
859657010826	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
859657010827	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859657010828	RNA binding surface [nucleotide binding]; other site
859657010829	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
859657010830	probable active site [active]
859657010831	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
859657010832	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
859657010833	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
859657010834	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
859657010835	ligand binding site [chemical binding]; other site
859657010836	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
859657010837	putative switch regulator; other site
859657010838	non-specific DNA interactions [nucleotide binding]; other site
859657010839	DNA binding site [nucleotide binding]
859657010840	sequence specific DNA binding site [nucleotide binding]; other site
859657010841	putative cAMP binding site [chemical binding]; other site
859657010842	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
859657010843	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
859657010844	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
859657010845	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
859657010846	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
859657010847	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282
859657010848	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
859657010849	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
859657010850	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
859657010851	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
859657010852	Low-spin heme binding site [chemical binding]; other site
859657010853	Putative water exit pathway; other site
859657010854	Binuclear center (active site) [active]
859657010855	Putative proton exit pathway; other site
859657010856	Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197
859657010857	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
859657010858	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
859657010859	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
859657010860	metal-binding site [ion binding]
859657010861	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
859657010862	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
859657010863	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
859657010864	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
859657010865	Predicted ATPase [General function prediction only]; Region: COG1485
859657010866	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
859657010867	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859657010868	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
859657010869	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
859657010870	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
859657010871	E3 interaction surface; other site
859657010872	lipoyl attachment site [posttranslational modification]; other site
859657010873	e3 binding domain; Region: E3_binding; pfam02817
859657010874	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
859657010875	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
859657010876	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
859657010877	TPP-binding site [chemical binding]; other site
859657010878	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
859657010879	dimer interface [polypeptide binding]; other site
859657010880	PYR/PP interface [polypeptide binding]; other site
859657010881	TPP binding site [chemical binding]; other site
859657010882	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
859657010883	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
859657010884	putative active site [active]
859657010885	catalytic site [active]
859657010886	putative metal binding site [ion binding]; other site
859657010887	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
859657010888	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
859657010889	Walker A/P-loop; other site
859657010890	ATP binding site [chemical binding]; other site
859657010891	Q-loop/lid; other site
859657010892	ABC transporter signature motif; other site
859657010893	Walker B; other site
859657010894	D-loop; other site
859657010895	H-loop/switch region; other site
859657010896	TOBE domain; Region: TOBE_2; pfam08402
859657010897	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
859657010898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657010899	dimer interface [polypeptide binding]; other site
859657010900	conserved gate region; other site
859657010901	putative PBP binding loops; other site
859657010902	ABC-ATPase subunit interface; other site
859657010903	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
859657010904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657010905	dimer interface [polypeptide binding]; other site
859657010906	conserved gate region; other site
859657010907	putative PBP binding loops; other site
859657010908	ABC-ATPase subunit interface; other site
859657010909	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
859657010910	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
859657010911	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
859657010912	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859657010913	active site
859657010914	motif I; other site
859657010915	motif II; other site
859657010916	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
859657010917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657010918	active site
859657010919	phosphorylation site [posttranslational modification]
859657010920	intermolecular recognition site; other site
859657010921	dimerization interface [polypeptide binding]; other site
859657010922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657010923	Walker A motif; other site
859657010924	ATP binding site [chemical binding]; other site
859657010925	Walker B motif; other site
859657010926	arginine finger; other site
859657010927	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859657010928	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
859657010929	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
859657010930	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657010931	dimer interface [polypeptide binding]; other site
859657010932	phosphorylation site [posttranslational modification]
859657010933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657010934	ATP binding site [chemical binding]; other site
859657010935	Mg2+ binding site [ion binding]; other site
859657010936	G-X-G motif; other site
859657010937	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
859657010938	glutamine synthetase; Provisional; Region: glnA; PRK09469
859657010939	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
859657010940	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
859657010941	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
859657010942	active site residue [active]
859657010943	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
859657010944	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
859657010945	putative MPT binding site; other site
859657010946	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
859657010947	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
859657010948	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
859657010949	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
859657010950	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
859657010951	NodB motif; other site
859657010952	active site
859657010953	catalytic site [active]
859657010954	metal binding site [ion binding]; metal-binding site
859657010955	Uncharacterized conserved protein [Function unknown]; Region: COG3391
859657010956	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
859657010957	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
859657010958	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859657010959	ATP binding site [chemical binding]; other site
859657010960	putative Mg++ binding site [ion binding]; other site
859657010961	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859657010962	nucleotide binding region [chemical binding]; other site
859657010963	ATP-binding site [chemical binding]; other site
859657010964	Helicase associated domain (HA2); Region: HA2; pfam04408
859657010965	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
859657010966	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
859657010967	N-acetylglutamate synthase; Validated; Region: PRK05279
859657010968	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
859657010969	putative feedback inhibition sensing region; other site
859657010970	putative nucleotide binding site [chemical binding]; other site
859657010971	putative substrate binding site [chemical binding]; other site
859657010972	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657010973	Coenzyme A binding pocket [chemical binding]; other site
859657010974	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
859657010975	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859657010976	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
859657010977	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
859657010978	KduI/IolB family; Region: KduI; pfam04962
859657010979	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
859657010980	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
859657010981	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
859657010982	PYR/PP interface [polypeptide binding]; other site
859657010983	dimer interface [polypeptide binding]; other site
859657010984	TPP binding site [chemical binding]; other site
859657010985	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
859657010986	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
859657010987	TPP-binding site [chemical binding]; other site
859657010988	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
859657010989	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
859657010990	substrate binding site [chemical binding]; other site
859657010991	ATP binding site [chemical binding]; other site
859657010992	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
859657010993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
859657010994	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859657010995	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
859657010996	TM-ABC transporter signature motif; other site
859657010997	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
859657010998	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
859657010999	Walker A/P-loop; other site
859657011000	ATP binding site [chemical binding]; other site
859657011001	Q-loop/lid; other site
859657011002	ABC transporter signature motif; other site
859657011003	Walker B; other site
859657011004	D-loop; other site
859657011005	H-loop/switch region; other site
859657011006	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
859657011007	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
859657011008	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
859657011009	putative ligand binding site [chemical binding]; other site
859657011010	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
859657011011	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859657011012	DNA binding site [nucleotide binding]
859657011013	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
859657011014	putative ligand binding site [chemical binding]; other site
859657011015	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
859657011016	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
859657011017	putative di-iron ligands [ion binding]; other site
859657011018	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
859657011019	[2Fe-2S] cluster binding site [ion binding]; other site
859657011020	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
859657011021	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
859657011022	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
859657011023	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
859657011024	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
859657011025	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859657011026	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
859657011027	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
859657011028	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
859657011029	putative active site [active]
859657011030	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
859657011031	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859657011032	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
859657011033	oxidative damage protection protein; Provisional; Region: PRK05408
859657011034	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657011035	dimerization interface [polypeptide binding]; other site
859657011036	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657011037	dimer interface [polypeptide binding]; other site
859657011038	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
859657011039	putative CheW interface [polypeptide binding]; other site
859657011040	Evidence 4 : Homologs of previously reported genes of unknown function
859657011041	phenylhydantoinase; Validated; Region: PRK08323
859657011042	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
859657011043	tetramer interface [polypeptide binding]; other site
859657011044	active site
859657011045	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
859657011046	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
859657011047	Na binding site [ion binding]; other site
859657011048	putative substrate binding site [chemical binding]; other site
859657011049	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
859657011050	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
859657011051	homodimer interface [polypeptide binding]; other site
859657011052	active site
859657011053	FMN binding site [chemical binding]; other site
859657011054	substrate binding site [chemical binding]; other site
859657011055	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
859657011056	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
859657011057	allantoate amidohydrolase; Reviewed; Region: PRK12893
859657011058	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
859657011059	active site
859657011060	metal binding site [ion binding]; metal-binding site
859657011061	dimer interface [polypeptide binding]; other site
859657011062	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
859657011063	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657011064	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
859657011065	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
859657011066	tetramer (dimer of dimers) interface [polypeptide binding]; other site
859657011067	active site
859657011068	dimer interface [polypeptide binding]; other site
859657011069	transaldolase-like protein; Provisional; Region: PTZ00411
859657011070	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
859657011071	active site
859657011072	dimer interface [polypeptide binding]; other site
859657011073	catalytic residue [active]
859657011074	NAD-dependent deacetylase; Provisional; Region: PRK00481
859657011075	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
859657011076	NAD+ binding site [chemical binding]; other site
859657011077	substrate binding site [chemical binding]; other site
859657011078	Zn binding site [ion binding]; other site
859657011079	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
859657011080	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
859657011081	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
859657011082	ribonuclease R; Region: RNase_R; TIGR02063
859657011083	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
859657011084	RNB domain; Region: RNB; pfam00773
859657011085	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
859657011086	RNA binding site [nucleotide binding]; other site
859657011087	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
859657011088	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859657011089	active site
859657011090	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
859657011091	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
859657011092	GDP-binding site [chemical binding]; other site
859657011093	ACT binding site; other site
859657011094	IMP binding site; other site
859657011095	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
859657011096	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
859657011097	dimer interface [polypeptide binding]; other site
859657011098	motif 1; other site
859657011099	active site
859657011100	motif 2; other site
859657011101	motif 3; other site
859657011102	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
859657011103	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
859657011104	HflC protein; Region: hflC; TIGR01932
859657011105	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
859657011106	HflK protein; Region: hflK; TIGR01933
859657011107	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
859657011108	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
859657011109	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
859657011110	HflX GTPase family; Region: HflX; cd01878
859657011111	G1 box; other site
859657011112	GTP/Mg2+ binding site [chemical binding]; other site
859657011113	Switch I region; other site
859657011114	G2 box; other site
859657011115	G3 box; other site
859657011116	Switch II region; other site
859657011117	G4 box; other site
859657011118	G5 box; other site
859657011119	bacterial Hfq-like; Region: Hfq; cd01716
859657011120	hexamer interface [polypeptide binding]; other site
859657011121	Sm1 motif; other site
859657011122	RNA binding site [nucleotide binding]; other site
859657011123	Sm2 motif; other site
859657011124	GTP-binding protein Der; Reviewed; Region: PRK00093
859657011125	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
859657011126	G1 box; other site
859657011127	GTP/Mg2+ binding site [chemical binding]; other site
859657011128	Switch I region; other site
859657011129	G2 box; other site
859657011130	Switch II region; other site
859657011131	G3 box; other site
859657011132	G4 box; other site
859657011133	G5 box; other site
859657011134	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
859657011135	G1 box; other site
859657011136	GTP/Mg2+ binding site [chemical binding]; other site
859657011137	Switch I region; other site
859657011138	G2 box; other site
859657011139	G3 box; other site
859657011140	Switch II region; other site
859657011141	G4 box; other site
859657011142	G5 box; other site
859657011143	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
859657011144	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
859657011145	Trp docking motif [polypeptide binding]; other site
859657011146	active site
859657011147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
859657011148	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
859657011149	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
859657011150	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
859657011151	dimer interface [polypeptide binding]; other site
859657011152	motif 1; other site
859657011153	active site
859657011154	motif 2; other site
859657011155	motif 3; other site
859657011156	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
859657011157	anticodon binding site; other site
859657011158	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
859657011159	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
859657011160	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
859657011161	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
859657011162	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657011163	non-specific DNA binding site [nucleotide binding]; other site
859657011164	salt bridge; other site
859657011165	sequence-specific DNA binding site [nucleotide binding]; other site
859657011166	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
859657011167	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
859657011168	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657011169	binding surface
859657011170	TPR motif; other site
859657011171	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657011172	binding surface
859657011173	TPR motif; other site
859657011174	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
859657011175	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657011176	FeS/SAM binding site; other site
859657011177	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
859657011178	active site
859657011179	multimer interface [polypeptide binding]; other site
859657011180	YccA-like proteins; Region: YccA_like; cd10433
859657011181	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
859657011182	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
859657011183	TRAM domain; Region: TRAM; pfam01938
859657011184	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
859657011185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657011186	S-adenosylmethionine binding site [chemical binding]; other site
859657011187	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
859657011188	putative catalytic site [active]
859657011189	putative metal binding site [ion binding]; other site
859657011190	putative phosphate binding site [ion binding]; other site
859657011191	putative catalytic site [active]
859657011192	putative phosphate binding site [ion binding]; other site
859657011193	putative metal binding site [ion binding]; other site
859657011194	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
859657011195	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
859657011196	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657011197	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
859657011198	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657011199	DNA binding residues [nucleotide binding]
859657011200	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
859657011201	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859657011202	Peptidase family M23; Region: Peptidase_M23; pfam01551
859657011203	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
859657011204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657011205	S-adenosylmethionine binding site [chemical binding]; other site
859657011206	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
859657011207	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
859657011208	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
859657011209	NAD(P) binding site [chemical binding]; other site
859657011210	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
859657011211	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
859657011212	FMN binding site [chemical binding]; other site
859657011213	active site
859657011214	substrate binding site [chemical binding]; other site
859657011215	catalytic residue [active]
859657011216	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657011217	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657011218	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
859657011219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657011220	dimer interface [polypeptide binding]; other site
859657011221	conserved gate region; other site
859657011222	putative PBP binding loops; other site
859657011223	ABC-ATPase subunit interface; other site
859657011224	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
859657011225	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
859657011226	Walker A/P-loop; other site
859657011227	ATP binding site [chemical binding]; other site
859657011228	Q-loop/lid; other site
859657011229	ABC transporter signature motif; other site
859657011230	Walker B; other site
859657011231	D-loop; other site
859657011232	H-loop/switch region; other site
859657011233	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
859657011234	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657011235	membrane-bound complex binding site; other site
859657011236	hinge residues; other site
859657011237	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
859657011238	CoA-transferase family III; Region: CoA_transf_3; pfam02515
859657011239	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657011240	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657011241	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
859657011242	putative dimerization interface [polypeptide binding]; other site
859657011243	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
859657011244	recombination protein RecR; Reviewed; Region: recR; PRK00076
859657011245	RecR protein; Region: RecR; pfam02132
859657011246	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
859657011247	putative active site [active]
859657011248	putative metal-binding site [ion binding]; other site
859657011249	tetramer interface [polypeptide binding]; other site
859657011250	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
859657011251	hypothetical protein; Validated; Region: PRK00153
859657011252	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
859657011253	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657011254	Walker A motif; other site
859657011255	ATP binding site [chemical binding]; other site
859657011256	Walker B motif; other site
859657011257	DNA polymerase III subunit delta'; Validated; Region: PRK08485
859657011258	arginine finger; other site
859657011259	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
859657011260	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
859657011261	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
859657011262	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
859657011263	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
859657011264	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
859657011265	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859657011266	catalytic residues [active]
859657011267	transcription termination factor Rho; Provisional; Region: rho; PRK09376
859657011268	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
859657011269	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
859657011270	RNA binding site [nucleotide binding]; other site
859657011271	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
859657011272	multimer interface [polypeptide binding]; other site
859657011273	Walker A motif; other site
859657011274	ATP binding site [chemical binding]; other site
859657011275	Walker B motif; other site
859657011276	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
859657011277	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657011278	Walker A motif; other site
859657011279	ATP binding site [chemical binding]; other site
859657011280	Walker B motif; other site
859657011281	arginine finger; other site
859657011282	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
859657011283	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657011284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
859657011285	active site
859657011286	phosphorylation site [posttranslational modification]
859657011287	intermolecular recognition site; other site
859657011288	dimerization interface [polypeptide binding]; other site
859657011289	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657011290	DNA binding residues [nucleotide binding]
859657011291	dimerization interface [polypeptide binding]; other site
859657011292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3228
859657011293	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
859657011294	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
859657011295	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
859657011296	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
859657011297	putative efflux protein, MATE family; Region: matE; TIGR00797
859657011298	cation binding site [ion binding]; other site
859657011299	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
859657011300	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
859657011301	active site
859657011302	HIGH motif; other site
859657011303	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
859657011304	active site
859657011305	KMSKS motif; other site
859657011306	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
859657011307	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
859657011308	nucleophile elbow; other site
859657011309	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
859657011310	NlpC/P60 family; Region: NLPC_P60; pfam00877
859657011311	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
859657011312	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859657011313	Walker A/P-loop; other site
859657011314	ATP binding site [chemical binding]; other site
859657011315	Q-loop/lid; other site
859657011316	ABC transporter signature motif; other site
859657011317	Walker B; other site
859657011318	D-loop; other site
859657011319	H-loop/switch region; other site
859657011320	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
859657011321	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859657011322	Walker A/P-loop; other site
859657011323	ATP binding site [chemical binding]; other site
859657011324	Q-loop/lid; other site
859657011325	ABC transporter signature motif; other site
859657011326	Walker B; other site
859657011327	D-loop; other site
859657011328	H-loop/switch region; other site
859657011329	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
859657011330	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
859657011331	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
859657011332	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657011333	dimer interface [polypeptide binding]; other site
859657011334	conserved gate region; other site
859657011335	putative PBP binding loops; other site
859657011336	ABC-ATPase subunit interface; other site
859657011337	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
859657011338	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657011339	dimer interface [polypeptide binding]; other site
859657011340	conserved gate region; other site
859657011341	putative PBP binding loops; other site
859657011342	ABC-ATPase subunit interface; other site
859657011343	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
859657011344	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
859657011345	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
859657011346	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
859657011347	NAD binding site [chemical binding]; other site
859657011348	homotetramer interface [polypeptide binding]; other site
859657011349	homodimer interface [polypeptide binding]; other site
859657011350	substrate binding site [chemical binding]; other site
859657011351	active site
859657011352	aspartate kinase; Reviewed; Region: PRK06635
859657011353	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
859657011354	putative Mg ion binding site [ion binding]; other site
859657011355	putative aspartate binding site [chemical binding]; other site
859657011356	putative catalytic residues [active]
859657011357	putative nucleotide binding site [chemical binding]; other site
859657011358	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
859657011359	putative allosteric regulatory site; other site
859657011360	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
859657011361	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
859657011362	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
859657011363	Ligand Binding Site [chemical binding]; other site
859657011364	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
859657011365	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
859657011366	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
859657011367	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
859657011368	endonuclease III; Region: ENDO3c; smart00478
859657011369	minor groove reading motif; other site
859657011370	helix-hairpin-helix signature motif; other site
859657011371	substrate binding pocket [chemical binding]; other site
859657011372	active site
859657011373	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
859657011374	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
859657011375	active site
859657011376	HIGH motif; other site
859657011377	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
859657011378	KMSKS motif; other site
859657011379	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
859657011380	tRNA binding surface [nucleotide binding]; other site
859657011381	anticodon binding site; other site
859657011382	TPR repeat; Region: TPR_11; pfam13414
859657011383	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657011384	binding surface
859657011385	TPR motif; other site
859657011386	TPR repeat; Region: TPR_11; pfam13414
859657011387	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
859657011388	substrate binding site [chemical binding]; other site
859657011389	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
859657011390	substrate binding site [chemical binding]; other site
859657011391	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859657011392	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
859657011393	putative active site [active]
859657011394	putative metal binding site [ion binding]; other site
859657011395	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
859657011396	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
859657011397	trimer interface [polypeptide binding]; other site
859657011398	active site
859657011399	substrate binding site [chemical binding]; other site
859657011400	CoA binding site [chemical binding]; other site
859657011401	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
859657011402	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
859657011403	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
859657011404	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
859657011405	active site
859657011406	dimerization interface [polypeptide binding]; other site
859657011407	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
859657011408	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657011409	non-specific DNA binding site [nucleotide binding]; other site
859657011410	salt bridge; other site
859657011411	sequence-specific DNA binding site [nucleotide binding]; other site
859657011412	Cupin domain; Region: Cupin_2; pfam07883
859657011413	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
859657011414	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
859657011415	catalytic triad [active]
859657011416	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
859657011417	MOSC domain; Region: MOSC; pfam03473
859657011418	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
859657011419	dimer interface [polypeptide binding]; other site
859657011420	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657011421	dimerization interface [polypeptide binding]; other site
859657011422	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657011423	dimer interface [polypeptide binding]; other site
859657011424	putative CheW interface [polypeptide binding]; other site
859657011425	Cache domain; Region: Cache_2; pfam08269
859657011426	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
859657011427	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657011428	dimer interface [polypeptide binding]; other site
859657011429	putative CheW interface [polypeptide binding]; other site
859657011430	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
859657011431	MutS domain I; Region: MutS_I; pfam01624
859657011432	MutS domain II; Region: MutS_II; pfam05188
859657011433	MutS domain III; Region: MutS_III; pfam05192
859657011434	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
859657011435	Walker A/P-loop; other site
859657011436	ATP binding site [chemical binding]; other site
859657011437	Q-loop/lid; other site
859657011438	ABC transporter signature motif; other site
859657011439	Walker B; other site
859657011440	D-loop; other site
859657011441	H-loop/switch region; other site
859657011442	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
859657011443	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
859657011444	Uncharacterized conserved protein [Function unknown]; Region: COG2850
859657011445	Cupin-like domain; Region: Cupin_8; pfam13621
859657011446	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
859657011447	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
859657011448	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
859657011449	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
859657011450	dihydrodipicolinate synthase; Region: dapA; TIGR00674
859657011451	dimer interface [polypeptide binding]; other site
859657011452	active site
859657011453	catalytic residue [active]
859657011454	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657011455	S-adenosylmethionine binding site [chemical binding]; other site
859657011456	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
859657011457	active site
859657011458	HIGH motif; other site
859657011459	dimer interface [polypeptide binding]; other site
859657011460	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859657011461	active site
859657011462	KMSKS motif; other site
859657011463	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
859657011464	Peptidase family M50; Region: Peptidase_M50; pfam02163
859657011465	active site
859657011466	putative substrate binding region [chemical binding]; other site
859657011467	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
859657011468	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
859657011469	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
859657011470	active site
859657011471	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
859657011472	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
859657011473	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859657011474	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
859657011475	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
859657011476	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
859657011477	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859657011478	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
859657011479	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
859657011480	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
859657011481	dinuclear metal binding motif [ion binding]; other site
859657011482	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
859657011483	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
859657011484	trimer interface [polypeptide binding]; other site
859657011485	putative metal binding site [ion binding]; other site
859657011486	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
859657011487	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
859657011488	dimerization interface [polypeptide binding]; other site
859657011489	domain crossover interface; other site
859657011490	redox-dependent activation switch; other site
859657011491	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
859657011492	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
859657011493	enolase; Provisional; Region: eno; PRK00077
859657011494	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
859657011495	dimer interface [polypeptide binding]; other site
859657011496	metal binding site [ion binding]; metal-binding site
859657011497	substrate binding pocket [chemical binding]; other site
859657011498	Uncharacterized conserved protein [Function unknown]; Region: COG5470
859657011499	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
859657011500	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
859657011501	CTP synthetase; Validated; Region: pyrG; PRK05380
859657011502	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
859657011503	Catalytic site [active]
859657011504	active site
859657011505	UTP binding site [chemical binding]; other site
859657011506	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
859657011507	active site
859657011508	putative oxyanion hole; other site
859657011509	catalytic triad [active]
859657011510	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859657011511	Serine hydrolase; Region: Ser_hydrolase; cl17834
859657011512	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
859657011513	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
859657011514	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
859657011515	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
859657011516	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
859657011517	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
859657011518	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
859657011519	Uncharacterized conserved protein [Function unknown]; Region: COG2308
859657011520	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
859657011521	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
859657011522	Competence protein; Region: Competence; pfam03772
859657011523	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
859657011524	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
859657011525	active site
859657011526	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
859657011527	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
859657011528	Walker A/P-loop; other site
859657011529	ATP binding site [chemical binding]; other site
859657011530	Q-loop/lid; other site
859657011531	ABC transporter signature motif; other site
859657011532	Walker B; other site
859657011533	D-loop; other site
859657011534	H-loop/switch region; other site
859657011535	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
859657011536	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
859657011537	FtsX-like permease family; Region: FtsX; pfam02687
859657011538	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
859657011539	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
859657011540	DHH family; Region: DHH; pfam01368
859657011541	DHHA1 domain; Region: DHHA1; pfam02272
859657011542	Ferredoxin [Energy production and conversion]; Region: COG1146
859657011543	4Fe-4S binding domain; Region: Fer4; cl02805
859657011544	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
859657011545	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312
859657011546	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859657011547	MarR family; Region: MarR_2; pfam12802
859657011548	Predicted membrane protein [Function unknown]; Region: COG2855
859657011549	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
859657011550	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657011551	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
859657011552	putative dimerization interface [polypeptide binding]; other site
859657011553	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
859657011554	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859657011555	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657011556	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657011557	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657011558	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859657011559	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
859657011560	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859657011561	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859657011562	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
859657011563	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
859657011564	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859657011565	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859657011566	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
859657011567	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
859657011568	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
859657011569	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
859657011570	3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147
859657011571	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
859657011572	conserved hypothetical protein; Region: TIGR02270
859657011573	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
859657011574	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
859657011575	Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216
859657011576	IHF - DNA interface [nucleotide binding]; other site
859657011577	IHF dimer interface [polypeptide binding]; other site
859657011578	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
859657011579	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
859657011580	Moco binding site; other site
859657011581	metal coordination site [ion binding]; other site
859657011582	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
859657011583	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
859657011584	Ubiquitin-like proteins; Region: UBQ; cl00155
859657011585	charged pocket; other site
859657011586	hydrophobic patch; other site
859657011587	VPS10 domain; Region: VPS10; smart00602
859657011588	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
859657011589	Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459
859657011590	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
859657011591	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
859657011592	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
859657011593	SnoaL-like domain; Region: SnoaL_2; pfam12680
859657011594	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657011595	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657011596	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859657011597	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657011598	non-specific DNA binding site [nucleotide binding]; other site
859657011599	salt bridge; other site
859657011600	sequence-specific DNA binding site [nucleotide binding]; other site
859657011601	Predicted permeases [General function prediction only]; Region: COG0679
859657011602	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657011603	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657011604	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
859657011605	putative dimerization interface [polypeptide binding]; other site
859657011606	benzoate transport; Region: 2A0115; TIGR00895
859657011607	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657011608	putative substrate translocation pore; other site
859657011609	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657011610	putative substrate translocation pore; other site
859657011611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657011612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657011613	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
859657011614	substrate binding pocket [chemical binding]; other site
859657011615	dimerization interface [polypeptide binding]; other site
859657011616	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
859657011617	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657011618	catalytic loop [active]
859657011619	iron binding site [ion binding]; other site
859657011620	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
859657011621	FAD binding pocket [chemical binding]; other site
859657011622	FAD binding motif [chemical binding]; other site
859657011623	phosphate binding motif [ion binding]; other site
859657011624	beta-alpha-beta structure motif; other site
859657011625	NAD binding pocket [chemical binding]; other site
859657011626	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
859657011627	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
859657011628	iron-sulfur cluster [ion binding]; other site
859657011629	[2Fe-2S] cluster binding site [ion binding]; other site
859657011630	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
859657011631	putative alpha subunit interface [polypeptide binding]; other site
859657011632	putative active site [active]
859657011633	putative substrate binding site [chemical binding]; other site
859657011634	Fe binding site [ion binding]; other site
859657011635	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
859657011636	inter-subunit interface; other site
859657011637	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
859657011638	[2Fe-2S] cluster binding site [ion binding]; other site
859657011639	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
859657011640	Cupin domain; Region: Cupin_2; pfam07883
859657011641	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
859657011642	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
859657011643	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
859657011644	maleylacetoacetate isomerase; Region: maiA; TIGR01262
859657011645	C-terminal domain interface [polypeptide binding]; other site
859657011646	GSH binding site (G-site) [chemical binding]; other site
859657011647	putative dimer interface [polypeptide binding]; other site
859657011648	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
859657011649	dimer interface [polypeptide binding]; other site
859657011650	N-terminal domain interface [polypeptide binding]; other site
859657011651	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
859657011652	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657011653	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657011654	trimer interface [polypeptide binding]; other site
859657011655	eyelet of channel; other site
859657011656	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
859657011657	active site
859657011658	catalytic residues [active]
859657011659	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859657011660	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859657011661	trimer interface [polypeptide binding]; other site
859657011662	eyelet of channel; other site
859657011663	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
859657011664	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
859657011665	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
859657011666	putative active site [active]
859657011667	putative catalytic site [active]
859657011668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657011669	D-galactonate transporter; Region: 2A0114; TIGR00893
859657011670	putative substrate translocation pore; other site
859657011671	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
859657011672	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
859657011673	active site
859657011674	tetramer interface [polypeptide binding]; other site
859657011675	Transcriptional regulators [Transcription]; Region: FadR; COG2186
859657011676	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657011677	DNA-binding site [nucleotide binding]; DNA binding site
859657011678	FCD domain; Region: FCD; pfam07729
859657011679	Predicted membrane protein [Function unknown]; Region: COG2261
859657011680	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657011681	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657011682	DNA binding site [nucleotide binding]
859657011683	Evidence 4 : Homologs of previously reported genes of unknown function
859657011684	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
859657011685	CHASE2 domain; Region: CHASE2; pfam05226
859657011686	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
859657011687	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657011688	dimer interface [polypeptide binding]; other site
859657011689	phosphorylation site [posttranslational modification]
859657011690	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657011691	ATP binding site [chemical binding]; other site
859657011692	Mg2+ binding site [ion binding]; other site
859657011693	G-X-G motif; other site
859657011694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
859657011695	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859657011696	FecR protein; Region: FecR; pfam04773
859657011697	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657011698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657011699	active site
859657011700	phosphorylation site [posttranslational modification]
859657011701	intermolecular recognition site; other site
859657011702	dimerization interface [polypeptide binding]; other site
859657011703	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657011704	DNA binding site [nucleotide binding]
859657011705	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
859657011706	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
859657011707	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
859657011708	GIY-YIG motif/motif A; other site
859657011709	active site
859657011710	catalytic site [active]
859657011711	putative DNA binding site [nucleotide binding]; other site
859657011712	metal binding site [ion binding]; metal-binding site
859657011713	UvrB/uvrC motif; Region: UVR; pfam02151
859657011714	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
859657011715	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
859657011716	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
859657011717	elongation factor P; Validated; Region: PRK00529
859657011718	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
859657011719	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
859657011720	RNA binding site [nucleotide binding]; other site
859657011721	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
859657011722	RNA binding site [nucleotide binding]; other site
859657011723	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
859657011724	beta-hexosaminidase; Provisional; Region: PRK05337
859657011725	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
859657011726	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
859657011727	active site
859657011728	hydrophilic channel; other site
859657011729	dimerization interface [polypeptide binding]; other site
859657011730	catalytic residues [active]
859657011731	active site lid [active]
859657011732	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
859657011733	Recombination protein O N terminal; Region: RecO_N; pfam11967
859657011734	Recombination protein O C terminal; Region: RecO_C; pfam02565
859657011735	GTPase Era; Reviewed; Region: era; PRK00089
859657011736	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
859657011737	G1 box; other site
859657011738	GTP/Mg2+ binding site [chemical binding]; other site
859657011739	Switch I region; other site
859657011740	G2 box; other site
859657011741	Switch II region; other site
859657011742	G3 box; other site
859657011743	G4 box; other site
859657011744	G5 box; other site
859657011745	KH domain; Region: KH_2; pfam07650
859657011746	ribonuclease III; Reviewed; Region: rnc; PRK00102
859657011747	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
859657011748	dimerization interface [polypeptide binding]; other site
859657011749	active site
859657011750	metal binding site [ion binding]; metal-binding site
859657011751	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
859657011752	dsRNA binding site [nucleotide binding]; other site
859657011753	signal peptidase I; Provisional; Region: PRK10861
859657011754	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
859657011755	Catalytic site [active]
859657011756	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
859657011757	GTP-binding protein LepA; Provisional; Region: PRK05433
859657011758	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
859657011759	G1 box; other site
859657011760	putative GEF interaction site [polypeptide binding]; other site
859657011761	GTP/Mg2+ binding site [chemical binding]; other site
859657011762	Switch I region; other site
859657011763	G2 box; other site
859657011764	G3 box; other site
859657011765	Switch II region; other site
859657011766	G4 box; other site
859657011767	G5 box; other site
859657011768	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
859657011769	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
859657011770	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
859657011771	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
859657011772	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
859657011773	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
859657011774	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
859657011775	protein binding site [polypeptide binding]; other site
859657011776	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
859657011777	protein binding site [polypeptide binding]; other site
859657011778	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
859657011779	anti-sigma E factor; Provisional; Region: rseB; PRK09455
859657011780	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
859657011781	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
859657011782	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
859657011783	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657011784	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657011785	DNA binding residues [nucleotide binding]
859657011786	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
859657011787	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
859657011788	dimer interface [polypeptide binding]; other site
859657011789	active site
859657011790	acyl carrier protein; Provisional; Region: acpP; PRK00982
859657011791	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
859657011792	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
859657011793	NAD(P) binding site [chemical binding]; other site
859657011794	homotetramer interface [polypeptide binding]; other site
859657011795	homodimer interface [polypeptide binding]; other site
859657011796	active site
859657011797	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
859657011798	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
859657011799	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
859657011800	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
859657011801	dimer interface [polypeptide binding]; other site
859657011802	active site
859657011803	CoA binding pocket [chemical binding]; other site
859657011804	putative phosphate acyltransferase; Provisional; Region: PRK05331
859657011805	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
859657011806	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
859657011807	Maf-like protein; Region: Maf; pfam02545
859657011808	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
859657011809	active site
859657011810	dimer interface [polypeptide binding]; other site
859657011811	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
859657011812	putative SAM binding site [chemical binding]; other site
859657011813	homodimer interface [polypeptide binding]; other site
859657011814	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
859657011815	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
859657011816	tandem repeat interface [polypeptide binding]; other site
859657011817	oligomer interface [polypeptide binding]; other site
859657011818	active site residues [active]
859657011819	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
859657011820	iron-sulfur cluster [ion binding]; other site
859657011821	[2Fe-2S] cluster binding site [ion binding]; other site
859657011822	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
859657011823	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859657011824	motif II; other site
859657011825	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
859657011826	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859657011827	RNA binding surface [nucleotide binding]; other site
859657011828	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
859657011829	active site
859657011830	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
859657011831	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
859657011832	homodimer interface [polypeptide binding]; other site
859657011833	oligonucleotide binding site [chemical binding]; other site
859657011834	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
859657011835	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657011836	FeS/SAM binding site; other site
859657011837	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
859657011838	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
859657011839	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
859657011840	GTP binding site; other site
859657011841	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
859657011842	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
859657011843	dimer interface [polypeptide binding]; other site
859657011844	putative functional site; other site
859657011845	putative MPT binding site; other site
859657011846	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
859657011847	RmuC family; Region: RmuC; pfam02646
859657011848	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
859657011849	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
859657011850	dimerization interface [polypeptide binding]; other site
859657011851	ligand binding site [chemical binding]; other site
859657011852	NADP binding site [chemical binding]; other site
859657011853	catalytic site [active]
859657011854	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
859657011855	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
859657011856	transmembrane helices; other site
859657011857	Uncharacterized conserved protein [Function unknown]; Region: COG1556
859657011858	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
859657011859	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
859657011860	active site
859657011861	peptide chain release factor 2; Provisional; Region: PRK08787
859657011862	This domain is found in peptide chain release factors; Region: PCRF; smart00937
859657011863	RF-1 domain; Region: RF-1; pfam00472
859657011864	short chain dehydrogenase; Provisional; Region: PRK07023
859657011865	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
859657011866	NADP binding site [chemical binding]; other site
859657011867	homodimer interface [polypeptide binding]; other site
859657011868	active site
859657011869	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
859657011870	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
859657011871	dimer interface [polypeptide binding]; other site
859657011872	putative anticodon binding site; other site
859657011873	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
859657011874	motif 1; other site
859657011875	active site
859657011876	motif 2; other site
859657011877	motif 3; other site
859657011878	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
859657011879	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
859657011880	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859657011881	catalytic loop [active]
859657011882	iron binding site [ion binding]; other site
859657011883	chaperone protein HscA; Provisional; Region: hscA; PRK05183
859657011884	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
859657011885	nucleotide binding site [chemical binding]; other site
859657011886	putative NEF/HSP70 interaction site [polypeptide binding]; other site
859657011887	SBD interface [polypeptide binding]; other site
859657011888	co-chaperone HscB; Provisional; Region: hscB; PRK03578
859657011889	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
859657011890	HSP70 interaction site [polypeptide binding]; other site
859657011891	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
859657011892	Protein of unknown function (DUF3565); Region: DUF3565; pfam12088
859657011893	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
859657011894	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
859657011895	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
859657011896	trimerization site [polypeptide binding]; other site
859657011897	active site
859657011898	cysteine desulfurase; Provisional; Region: PRK14012
859657011899	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
859657011900	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859657011901	catalytic residue [active]
859657011902	Predicted transcriptional regulator [Transcription]; Region: COG1959
859657011903	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
859657011904	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
859657011905	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
859657011906	ligand binding site [chemical binding]; other site
859657011907	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
859657011908	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
859657011909	Walker A/P-loop; other site
859657011910	ATP binding site [chemical binding]; other site
859657011911	Q-loop/lid; other site
859657011912	ABC transporter signature motif; other site
859657011913	Walker B; other site
859657011914	D-loop; other site
859657011915	H-loop/switch region; other site
859657011916	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
859657011917	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859657011918	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
859657011919	TM-ABC transporter signature motif; other site
859657011920	Transcriptional regulators [Transcription]; Region: PurR; COG1609
859657011921	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859657011922	DNA binding site [nucleotide binding]
859657011923	domain linker motif; other site
859657011924	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
859657011925	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
859657011926	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
859657011927	substrate binding site [chemical binding]; other site
859657011928	dimer interface [polypeptide binding]; other site
859657011929	ATP binding site [chemical binding]; other site
859657011930	Site-specific recombinase; Region: SpecificRecomb; cl15411
859657011931	excinuclease ABC subunit B; Provisional; Region: PRK05298
859657011932	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859657011933	ATP binding site [chemical binding]; other site
859657011934	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859657011935	nucleotide binding region [chemical binding]; other site
859657011936	ATP-binding site [chemical binding]; other site
859657011937	Ultra-violet resistance protein B; Region: UvrB; pfam12344
859657011938	UvrB/uvrC motif; Region: UVR; pfam02151
859657011939	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
859657011940	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657011941	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657011942	homodimer interface [polypeptide binding]; other site
859657011943	catalytic residue [active]
859657011944	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
859657011945	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
859657011946	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657011947	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657011948	ferredoxin; Provisional; Region: PRK06991
859657011949	Putative Fe-S cluster; Region: FeS; pfam04060
859657011950	4Fe-4S binding domain; Region: Fer4; pfam00037
859657011951	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
859657011952	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
859657011953	minor groove reading motif; other site
859657011954	helix-hairpin-helix signature motif; other site
859657011955	substrate binding pocket [chemical binding]; other site
859657011956	active site
859657011957	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
859657011958	putative FMN binding site [chemical binding]; other site
859657011959	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
859657011960	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
859657011961	EamA-like transporter family; Region: EamA; pfam00892
859657011962	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
859657011963	EamA-like transporter family; Region: EamA; pfam00892
859657011964	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
859657011965	Cytochrome c553 [Energy production and conversion]; Region: COG2863
859657011966	Cytochrome c553 [Energy production and conversion]; Region: COG2863
859657011967	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
859657011968	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657011969	Walker A motif; other site
859657011970	ATP binding site [chemical binding]; other site
859657011971	Walker B motif; other site
859657011972	arginine finger; other site
859657011973	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
859657011974	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
859657011975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
859657011976	S-adenosylmethionine binding site [chemical binding]; other site
859657011977	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
859657011978	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
859657011979	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657011980	dimerization interface [polypeptide binding]; other site
859657011981	putative DNA binding site [nucleotide binding]; other site
859657011982	putative Zn2+ binding site [ion binding]; other site
859657011983	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
859657011984	putative hydrophobic ligand binding site [chemical binding]; other site
859657011985	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
859657011986	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859657011987	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
859657011988	N-terminal domain interface [polypeptide binding]; other site
859657011989	dimer interface [polypeptide binding]; other site
859657011990	substrate binding pocket (H-site) [chemical binding]; other site
859657011991	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
859657011992	putative active site [active]
859657011993	heat shock protein 90; Provisional; Region: PRK05218
859657011994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657011995	ATP binding site [chemical binding]; other site
859657011996	Mg2+ binding site [ion binding]; other site
859657011997	G-X-G motif; other site
859657011998	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
859657011999	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657012000	DNA-binding site [nucleotide binding]; DNA binding site
859657012001	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657012002	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657012003	homodimer interface [polypeptide binding]; other site
859657012004	catalytic residue [active]
859657012005	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
859657012006	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
859657012007	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657012008	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657012009	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
859657012010	homotrimer interaction site [polypeptide binding]; other site
859657012011	putative active site [active]
859657012012	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
859657012013	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657012014	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657012015	homodimer interface [polypeptide binding]; other site
859657012016	catalytic residue [active]
859657012017	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859657012018	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
859657012019	putative C-terminal domain interface [polypeptide binding]; other site
859657012020	putative GSH binding site (G-site) [chemical binding]; other site
859657012021	putative dimer interface [polypeptide binding]; other site
859657012022	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
859657012023	putative N-terminal domain interface [polypeptide binding]; other site
859657012024	putative dimer interface [polypeptide binding]; other site
859657012025	putative substrate binding pocket (H-site) [chemical binding]; other site
859657012026	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
859657012027	MASE1; Region: MASE1; pfam05231
859657012028	PAS fold; Region: PAS_3; pfam08447
859657012029	hypothetical protein; Provisional; Region: PRK10279
859657012030	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
859657012031	active site
859657012032	nucleophile elbow; other site
859657012033	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
859657012034	Surface antigen; Region: Bac_surface_Ag; pfam01103
859657012035	L-lactate permease; Region: Lactate_perm; cl00701
859657012036	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
859657012037	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657012038	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657012039	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
859657012040	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
859657012041	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
859657012042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
859657012043	CAP-like domain; other site
859657012044	active site
859657012045	primary dimer interface [polypeptide binding]; other site
859657012046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859657012047	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859657012048	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859657012049	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859657012050	catalytic residue [active]
859657012051	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
859657012052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657012053	ATP binding site [chemical binding]; other site
859657012054	Mg2+ binding site [ion binding]; other site
859657012055	G-X-G motif; other site
859657012056	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
859657012057	anchoring element; other site
859657012058	dimer interface [polypeptide binding]; other site
859657012059	ATP binding site [chemical binding]; other site
859657012060	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
859657012061	active site
859657012062	metal binding site [ion binding]; metal-binding site
859657012063	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
859657012064	ABC transporter ATPase component; Reviewed; Region: PRK11147
859657012065	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859657012066	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859657012067	ABC transporter; Region: ABC_tran_2; pfam12848
859657012068	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859657012069	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
859657012070	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657012071	substrate binding pocket [chemical binding]; other site
859657012072	membrane-bound complex binding site; other site
859657012073	hinge residues; other site
859657012074	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
859657012075	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
859657012076	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
859657012077	putative ion selectivity filter; other site
859657012078	putative pore gating glutamate residue; other site
859657012079	putative H+/Cl- coupling transport residue; other site
859657012080	helicase 45; Provisional; Region: PTZ00424
859657012081	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
859657012082	ATP binding site [chemical binding]; other site
859657012083	Mg++ binding site [ion binding]; other site
859657012084	motif III; other site
859657012085	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859657012086	nucleotide binding region [chemical binding]; other site
859657012087	ATP-binding site [chemical binding]; other site
859657012088	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
859657012089	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
859657012090	Uncharacterized conserved protein [Function unknown]; Region: COG4301
859657012091	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
859657012092	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
859657012093	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
859657012094	hypothetical protein; Provisional; Region: PRK06815
859657012095	tetramer interface [polypeptide binding]; other site
859657012096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657012097	catalytic residue [active]
859657012098	thymidylate synthase; Reviewed; Region: thyA; PRK01827
859657012099	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
859657012100	dimerization interface [polypeptide binding]; other site
859657012101	active site
859657012102	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
859657012103	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
859657012104	folate binding site [chemical binding]; other site
859657012105	NADP+ binding site [chemical binding]; other site
859657012106	peptidase PmbA; Provisional; Region: PRK11040
859657012107	hypothetical protein; Provisional; Region: PRK05255
859657012108	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
859657012109	MPT binding site; other site
859657012110	trimer interface [polypeptide binding]; other site
859657012111	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
859657012112	catalytic site [active]
859657012113	putative active site [active]
859657012114	putative substrate binding site [chemical binding]; other site
859657012115	dimer interface [polypeptide binding]; other site
859657012116	Peptidase family M48; Region: Peptidase_M48; cl12018
859657012117	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
859657012118	GTPase RsgA; Reviewed; Region: PRK00098
859657012119	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
859657012120	RNA binding site [nucleotide binding]; other site
859657012121	homodimer interface [polypeptide binding]; other site
859657012122	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
859657012123	GTPase/Zn-binding domain interface [polypeptide binding]; other site
859657012124	GTP/Mg2+ binding site [chemical binding]; other site
859657012125	G4 box; other site
859657012126	G5 box; other site
859657012127	G1 box; other site
859657012128	Switch I region; other site
859657012129	G2 box; other site
859657012130	G3 box; other site
859657012131	Switch II region; other site
859657012132	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
859657012133	CobD/CbiB family protein; Provisional; Region: PRK07630
859657012134	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
859657012135	putative active site [active]
859657012136	putative CoA binding site [chemical binding]; other site
859657012137	nudix motif; other site
859657012138	metal binding site [ion binding]; metal-binding site
859657012139	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
859657012140	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
859657012141	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
859657012142	RimM N-terminal domain; Region: RimM; pfam01782
859657012143	PRC-barrel domain; Region: PRC; pfam05239
859657012144	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
859657012145	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
859657012146	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
859657012147	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
859657012148	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657012149	FeS/SAM binding site; other site
859657012150	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
859657012151	AsnC family; Region: AsnC_trans_reg; pfam01037
859657012152	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
859657012153	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859657012154	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
859657012155	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
859657012156	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859657012157	active site
859657012158	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
859657012159	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
859657012160	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
859657012161	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
859657012162	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
859657012163	Ligand binding site [chemical binding]; other site
859657012164	Electron transfer flavoprotein domain; Region: ETF; pfam01012
859657012165	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
859657012166	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
859657012167	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657012168	dimer interface [polypeptide binding]; other site
859657012169	conserved gate region; other site
859657012170	ABC-ATPase subunit interface; other site
859657012171	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
859657012172	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
859657012173	Walker A/P-loop; other site
859657012174	ATP binding site [chemical binding]; other site
859657012175	Q-loop/lid; other site
859657012176	ABC transporter signature motif; other site
859657012177	Walker B; other site
859657012178	D-loop; other site
859657012179	H-loop/switch region; other site
859657012180	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
859657012181	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
859657012182	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
859657012183	putative active site [active]
859657012184	Zn binding site [ion binding]; other site
859657012185	Transglycosylase SLT domain; Region: SLT_2; pfam13406
859657012186	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859657012187	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859657012188	cysteine synthase B; Region: cysM; TIGR01138
859657012189	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
859657012190	dimer interface [polypeptide binding]; other site
859657012191	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657012192	catalytic residue [active]
859657012193	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
859657012194	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
859657012195	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
859657012196	NADP binding site [chemical binding]; other site
859657012197	homopentamer interface [polypeptide binding]; other site
859657012198	substrate binding site [chemical binding]; other site
859657012199	active site
859657012200	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
859657012201	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
859657012202	putative ribose interaction site [chemical binding]; other site
859657012203	putative ADP binding site [chemical binding]; other site
859657012204	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
859657012205	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
859657012206	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
859657012207	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
859657012208	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
859657012209	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657012210	binding surface
859657012211	TPR motif; other site
859657012212	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
859657012213	binding surface
859657012214	TPR motif; other site
859657012215	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
859657012216	IHF dimer interface [polypeptide binding]; other site
859657012217	IHF - DNA interface [nucleotide binding]; other site
859657012218	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
859657012219	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
859657012220	RNA binding site [nucleotide binding]; other site
859657012221	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
859657012222	RNA binding site [nucleotide binding]; other site
859657012223	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
859657012224	RNA binding site [nucleotide binding]; other site
859657012225	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
859657012226	RNA binding site [nucleotide binding]; other site
859657012227	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
859657012228	RNA binding site [nucleotide binding]; other site
859657012229	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
859657012230	RNA binding site [nucleotide binding]; other site
859657012231	cytidylate kinase; Provisional; Region: cmk; PRK00023
859657012232	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
859657012233	CMP-binding site; other site
859657012234	The sites determining sugar specificity; other site
859657012235	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
859657012236	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
859657012237	hinge; other site
859657012238	active site
859657012239	Prephenate dehydrogenase; Region: PDH; pfam02153
859657012240	prephenate dehydrogenase; Validated; Region: PRK08507
859657012241	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
859657012242	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657012243	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657012244	homodimer interface [polypeptide binding]; other site
859657012245	catalytic residue [active]
859657012246	Chorismate mutase type II; Region: CM_2; cl00693
859657012247	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
859657012248	Prephenate dehydratase; Region: PDT; pfam00800
859657012249	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
859657012250	putative L-Phe binding site [chemical binding]; other site
859657012251	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
859657012252	homodimer interface [polypeptide binding]; other site
859657012253	substrate-cofactor binding pocket; other site
859657012254	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657012255	catalytic residue [active]
859657012256	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
859657012257	DNA gyrase subunit A; Validated; Region: PRK05560
859657012258	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
859657012259	CAP-like domain; other site
859657012260	active site
859657012261	primary dimer interface [polypeptide binding]; other site
859657012262	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859657012263	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859657012264	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859657012265	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859657012266	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859657012267	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859657012268	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
859657012269	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
859657012270	ligand binding site [chemical binding]; other site
859657012271	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
859657012272	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
859657012273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657012274	S-adenosylmethionine binding site [chemical binding]; other site
859657012275	phosphoglycolate phosphatase; Provisional; Region: PRK13222
859657012276	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859657012277	motif II; other site
859657012278	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
859657012279	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
859657012280	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
859657012281	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
859657012282	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
859657012283	ligand binding site [chemical binding]; other site
859657012284	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
859657012285	Integrase core domain; Region: rve; pfam00665
859657012286	Integrase core domain; Region: rve_3; pfam13683
859657012287	Transposase; Region: HTH_Tnp_1; cl17663
859657012288	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
859657012289	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
859657012290	Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin
859657012291	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
859657012292	DNA-binding interface [nucleotide binding]; DNA binding site
859657012293	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859657012294	HTH-like domain; Region: HTH_21; pfam13276
859657012295	Integrase core domain; Region: rve; pfam00665
859657012296	Integrase core domain; Region: rve_3; pfam13683
859657012297	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
859657012298	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
859657012299	Transposase; Region: HTH_Tnp_1; pfam01527
859657012300	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657012301	DNA methylase; Region: N6_N4_Mtase; pfam01555
859657012302	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
859657012303	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
859657012304	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
859657012305	active site
859657012306	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
859657012307	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
859657012308	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
859657012309	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
859657012310	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
859657012311	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
859657012312	Walker A/P-loop; other site
859657012313	ATP binding site [chemical binding]; other site
859657012314	Q-loop/lid; other site
859657012315	ABC transporter signature motif; other site
859657012316	Walker B; other site
859657012317	D-loop; other site
859657012318	H-loop/switch region; other site
859657012319	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
859657012320	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859657012321	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
859657012322	FlgN protein; Region: FlgN; pfam05130
859657012323	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
859657012324	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859657012325	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
859657012326	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859657012327	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
859657012328	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
859657012329	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
859657012330	active site
859657012331	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
859657012332	Methyltransferase domain; Region: Methyltransf_23; pfam13489
859657012333	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
859657012334	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
859657012335	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
859657012336	NADP-binding site; other site
859657012337	homotetramer interface [polypeptide binding]; other site
859657012338	substrate binding site [chemical binding]; other site
859657012339	homodimer interface [polypeptide binding]; other site
859657012340	active site
859657012341	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
859657012342	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
859657012343	NADP-binding site; other site
859657012344	homotetramer interface [polypeptide binding]; other site
859657012345	substrate binding site [chemical binding]; other site
859657012346	homodimer interface [polypeptide binding]; other site
859657012347	active site
859657012348	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859657012349	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
859657012350	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
859657012351	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
859657012352	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
859657012353	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859657012354	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657012355	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
859657012356	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
859657012357	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859657012358	HTH-like domain; Region: HTH_21; pfam13276
859657012359	Integrase core domain; Region: rve; pfam00665
859657012360	Integrase core domain; Region: rve_3; pfam13683
859657012361	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
859657012362	DNA-binding interface [nucleotide binding]; DNA binding site
859657012363	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
859657012364	putative hydrophobic ligand binding site [chemical binding]; other site
859657012365	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657012366	dimerization interface [polypeptide binding]; other site
859657012367	putative DNA binding site [nucleotide binding]; other site
859657012368	putative Zn2+ binding site [ion binding]; other site
859657012369	Fungal fucose-specific lectin; Region: Fungal_lectin; pfam07938
859657012370	Avirulence protein; Region: AvrB_AvrC; pfam05394
859657012371	hypothetical protein; Validated; Region: PRK09169
859657012372	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
859657012373	metal binding triad [ion binding]; metal-binding site
859657012374	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
859657012375	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
859657012376	glutathionine S-transferase; Provisional; Region: PRK10542
859657012377	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
859657012378	C-terminal domain interface [polypeptide binding]; other site
859657012379	GSH binding site (G-site) [chemical binding]; other site
859657012380	dimer interface [polypeptide binding]; other site
859657012381	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
859657012382	dimer interface [polypeptide binding]; other site
859657012383	N-terminal domain interface [polypeptide binding]; other site
859657012384	substrate binding pocket (H-site) [chemical binding]; other site
859657012385	Predicted transcriptional regulators [Transcription]; Region: COG1733
859657012386	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
859657012387	Predicted integral membrane protein [Function unknown]; Region: COG5455
859657012388	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859657012389	Ligand Binding Site [chemical binding]; other site
859657012390	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
859657012391	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
859657012392	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
859657012393	Moco binding site; other site
859657012394	metal coordination site [ion binding]; other site
859657012395	Cytochrome c; Region: Cytochrom_C; cl11414
859657012396	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
859657012397	CPxP  motif; other site
859657012398	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
859657012399	nudix motif; other site
859657012400	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
859657012401	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
859657012402	tetramer interface [polypeptide binding]; other site
859657012403	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657012404	catalytic residue [active]
859657012405	4-oxalocrotonate tautomerase; Provisional; Region: PRK00745
859657012406	active site 1 [active]
859657012407	dimer interface [polypeptide binding]; other site
859657012408	hexamer interface [polypeptide binding]; other site
859657012409	active site 2 [active]
859657012410	aldolase II superfamily protein; Provisional; Region: PRK07044
859657012411	intersubunit interface [polypeptide binding]; other site
859657012412	active site
859657012413	Zn2+ binding site [ion binding]; other site
859657012414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657012415	putative substrate translocation pore; other site
859657012416	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657012417	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657012418	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859657012419	dimerization interface [polypeptide binding]; other site
859657012420	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
859657012421	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
859657012422	dimer interface [polypeptide binding]; other site
859657012423	active site residues [active]
859657012424	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
859657012425	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
859657012426	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
859657012427	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
859657012428	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859657012429	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859657012430	N-terminal plug; other site
859657012431	ligand-binding site [chemical binding]; other site
859657012432	Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042
859657012433	Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042
859657012434	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
859657012435	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
859657012436	motif 1; other site
859657012437	active site
859657012438	motif 2; other site
859657012439	motif 3; other site
859657012440	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
859657012441	DHHA1 domain; Region: DHHA1; pfam02272
859657012442	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
859657012443	CoA-transferase family III; Region: CoA_transf_3; pfam02515
859657012444	Predicted membrane protein [Function unknown]; Region: COG3556
859657012445	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
859657012446	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
859657012447	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
859657012448	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859657012449	active site
859657012450	HIGH motif; other site
859657012451	nucleotide binding site [chemical binding]; other site
859657012452	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
859657012453	KMSKS motif; other site
859657012454	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
859657012455	Uncharacterized conserved protein [Function unknown]; Region: COG2353
859657012456	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
859657012457	Predicted membrane protein [Function unknown]; Region: COG3686
859657012458	Protein of unknown function (DUF3999); Region: DUF3999; pfam13163
859657012459	Protein of unknown function (DUF3999); Region: DUF3999; pfam13163
859657012460	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
859657012461	YaeQ protein; Region: YaeQ; pfam07152
859657012462	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
859657012463	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
859657012464	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
859657012465	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
859657012466	putative active site pocket [active]
859657012467	dimerization interface [polypeptide binding]; other site
859657012468	putative catalytic residue [active]
859657012469	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
859657012470	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657012471	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859657012472	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657012473	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
859657012474	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657012475	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
859657012476	acyl-activating enzyme (AAE) consensus motif; other site
859657012477	putative AMP binding site [chemical binding]; other site
859657012478	putative active site [active]
859657012479	putative CoA binding site [chemical binding]; other site
859657012480	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
859657012481	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
859657012482	catalytic residues [active]
859657012483	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
859657012484	binding surface
859657012485	TPR motif; other site
859657012486	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
859657012487	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
859657012488	catalytic residues [active]
859657012489	Hemerythrin; Region: Hemerythrin; cd12107
859657012490	Fe binding site [ion binding]; other site
859657012491	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
859657012492	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
859657012493	dimer interface [polypeptide binding]; other site
859657012494	active site
859657012495	heme binding site [chemical binding]; other site
859657012496	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
859657012497	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
859657012498	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
859657012499	putative ATP binding site [chemical binding]; other site
859657012500	putative substrate interface [chemical binding]; other site
859657012501	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
859657012502	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
859657012503	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
859657012504	Cytochrome c; Region: Cytochrom_C; pfam00034
859657012505	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
859657012506	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
859657012507	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
859657012508	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
859657012509	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
859657012510	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
859657012511	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
859657012512	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
859657012513	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
859657012514	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
859657012515	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
859657012516	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
859657012517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657012518	S-adenosylmethionine binding site [chemical binding]; other site
859657012519	Protein of unknown function DUF72; Region: DUF72; cl00777
859657012520	methionine sulfoxide reductase A; Provisional; Region: PRK14054
859657012521	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
859657012522	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
859657012523	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859657012524	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657012525	putative DNA binding site [nucleotide binding]; other site
859657012526	putative Zn2+ binding site [ion binding]; other site
859657012527	AsnC family; Region: AsnC_trans_reg; pfam01037
859657012528	arylformamidase; Region: trp_arylform; TIGR03035
859657012529	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
859657012530	kynureninase; Region: kynureninase; TIGR01814
859657012531	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859657012532	catalytic residue [active]
859657012533	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
859657012534	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859657012535	Transcriptional regulator [Transcription]; Region: IclR; COG1414
859657012536	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
859657012537	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859657012538	FAD binding site [chemical binding]; other site
859657012539	substrate binding pocket [chemical binding]; other site
859657012540	catalytic base [active]
859657012541	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
859657012542	Sulfate transporter family; Region: Sulfate_transp; pfam00916
859657012543	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
859657012544	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
859657012545	dimer interface [polypeptide binding]; other site
859657012546	decamer (pentamer of dimers) interface [polypeptide binding]; other site
859657012547	catalytic triad [active]
859657012548	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
859657012549	Predicted membrane protein [Function unknown]; Region: COG5393
859657012550	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
859657012551	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
859657012552	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657012553	Walker A/P-loop; other site
859657012554	ATP binding site [chemical binding]; other site
859657012555	Q-loop/lid; other site
859657012556	ABC transporter signature motif; other site
859657012557	Walker B; other site
859657012558	D-loop; other site
859657012559	H-loop/switch region; other site
859657012560	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
859657012561	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
859657012562	nudix motif; other site
859657012563	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
859657012564	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
859657012565	active site
859657012566	iron coordination sites [ion binding]; other site
859657012567	substrate binding pocket [chemical binding]; other site
859657012568	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859657012569	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
859657012570	active site
859657012571	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
859657012572	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
859657012573	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
859657012574	active site
859657012575	substrate binding site [chemical binding]; other site
859657012576	Mg2+ binding site [ion binding]; other site
859657012577	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
859657012578	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
859657012579	Predicted transporter component [General function prediction only]; Region: COG2391
859657012580	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
859657012581	Ligand Binding Site [chemical binding]; other site
859657012582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
859657012583	Tetratricopeptide repeat; Region: TPR_6; pfam13174
859657012584	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
859657012585	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
859657012586	ligand binding site [chemical binding]; other site
859657012587	translocation protein TolB; Provisional; Region: tolB; PRK02889
859657012588	TolB amino-terminal domain; Region: TolB_N; pfam04052
859657012589	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
859657012590	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
859657012591	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
859657012592	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
859657012593	TolA protein; Region: tolA_full; TIGR02794
859657012594	TonB C terminal; Region: TonB_2; pfam13103
859657012595	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
859657012596	TolR protein; Region: tolR; TIGR02801
859657012597	TolQ protein; Region: tolQ; TIGR02796
859657012598	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
859657012599	active site
859657012600	malonic semialdehyde reductase; Provisional; Region: PRK10538
859657012601	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657012602	NAD(P) binding site [chemical binding]; other site
859657012603	active site
859657012604	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
859657012605	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
859657012606	dimer interface [polypeptide binding]; other site
859657012607	active site
859657012608	glycine-pyridoxal phosphate binding site [chemical binding]; other site
859657012609	folate binding site [chemical binding]; other site
859657012610	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
859657012611	ATP cone domain; Region: ATP-cone; pfam03477
859657012612	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
859657012613	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
859657012614	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
859657012615	PilX N-terminal; Region: PilX_N; pfam14341
859657012616	Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681
859657012617	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
859657012618	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
859657012619	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
859657012620	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
859657012621	Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963
859657012622	Type II transport protein GspH; Region: GspH; pfam12019
859657012623	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
859657012624	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
859657012625	Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681
859657012626	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
859657012627	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
859657012628	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
859657012629	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
859657012630	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
859657012631	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
859657012632	catalytic motif [active]
859657012633	Zn binding site [ion binding]; other site
859657012634	RibD C-terminal domain; Region: RibD_C; cl17279
859657012635	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
859657012636	Lumazine binding domain; Region: Lum_binding; pfam00677
859657012637	Lumazine binding domain; Region: Lum_binding; pfam00677
859657012638	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
859657012639	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
859657012640	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
859657012641	dimerization interface [polypeptide binding]; other site
859657012642	active site
859657012643	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
859657012644	homopentamer interface [polypeptide binding]; other site
859657012645	active site
859657012646	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
859657012647	aminotransferase; Validated; Region: PRK07337
859657012648	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657012649	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657012650	homodimer interface [polypeptide binding]; other site
859657012651	catalytic residue [active]
859657012652	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859657012653	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859657012654	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859657012655	catalytic residue [active]
859657012656	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
859657012657	succinic semialdehyde dehydrogenase; Region: PLN02278
859657012658	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
859657012659	tetramerization interface [polypeptide binding]; other site
859657012660	NAD(P) binding site [chemical binding]; other site
859657012661	catalytic residues [active]
859657012662	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
859657012663	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
859657012664	acyl-activating enzyme (AAE) consensus motif; other site
859657012665	putative AMP binding site [chemical binding]; other site
859657012666	putative active site [active]
859657012667	putative CoA binding site [chemical binding]; other site
859657012668	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4318
859657012669	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
859657012670	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
859657012671	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
859657012672	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657012673	FeS/SAM binding site; other site
859657012674	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
859657012675	ferredoxin-NADP+ reductase; Region: PLN02852
859657012676	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859657012677	Ferredoxin [Energy production and conversion]; Region: COG1146
859657012678	4Fe-4S binding domain; Region: Fer4; pfam00037
859657012679	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
859657012680	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
859657012681	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
859657012682	putative [4Fe-4S] binding site [ion binding]; other site
859657012683	putative molybdopterin cofactor binding site [chemical binding]; other site
859657012684	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
859657012685	putative molybdopterin cofactor binding site; other site
859657012686	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
859657012687	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657012688	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657012689	HNH endonuclease; Region: HNH_5; pfam14279
859657012690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657012691	S-adenosylmethionine binding site [chemical binding]; other site
859657012692	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
859657012693	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
859657012694	active site
859657012695	FMN binding site [chemical binding]; other site
859657012696	substrate binding site [chemical binding]; other site
859657012697	homotetramer interface [polypeptide binding]; other site
859657012698	catalytic residue [active]
859657012699	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
859657012700	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
859657012701	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657012702	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657012703	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
859657012704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657012705	S-adenosylmethionine binding site [chemical binding]; other site
859657012706	Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528
859657012707	active site residue [active]
859657012708	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
859657012709	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
859657012710	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
859657012711	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
859657012712	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
859657012713	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
859657012714	putative active site [active]
859657012715	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
859657012716	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
859657012717	active site
859657012718	substrate binding site [chemical binding]; other site
859657012719	metal binding site [ion binding]; metal-binding site
859657012720	Chain length determinant protein; Region: Wzz; cl15801
859657012721	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
859657012722	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
859657012723	Mg++ binding site [ion binding]; other site
859657012724	putative catalytic motif [active]
859657012725	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
859657012726	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
859657012727	Probable Catalytic site; other site
859657012728	metal-binding site
859657012729	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
859657012730	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
859657012731	Ligand binding site; other site
859657012732	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
859657012733	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
859657012734	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
859657012735	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
859657012736	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
859657012737	substrate binding site; other site
859657012738	tetramer interface; other site
859657012739	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
859657012740	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
859657012741	NADP binding site [chemical binding]; other site
859657012742	active site
859657012743	putative substrate binding site [chemical binding]; other site
859657012744	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
859657012745	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
859657012746	NAD binding site [chemical binding]; other site
859657012747	substrate binding site [chemical binding]; other site
859657012748	homodimer interface [polypeptide binding]; other site
859657012749	active site
859657012750	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
859657012751	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
859657012752	active site
859657012753	metal binding site [ion binding]; metal-binding site
859657012754	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
859657012755	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
859657012756	putative acyl-acceptor binding pocket; other site
859657012757	dihydroorotase; Provisional; Region: PRK07627
859657012758	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859657012759	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
859657012760	active site
859657012761	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
859657012762	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
859657012763	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
859657012764	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
859657012765	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859657012766	active site
859657012767	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
859657012768	hypothetical protein; Validated; Region: PRK00228
859657012769	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
859657012770	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859657012771	RNA binding surface [nucleotide binding]; other site
859657012772	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
859657012773	active site
859657012774	uracil binding [chemical binding]; other site
859657012775	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
859657012776	putative binding surface; other site
859657012777	active site
859657012778	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
859657012779	putative binding surface; other site
859657012780	active site
859657012781	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
859657012782	putative binding surface; other site
859657012783	active site
859657012784	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
859657012785	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657012786	ATP binding site [chemical binding]; other site
859657012787	Mg2+ binding site [ion binding]; other site
859657012788	G-X-G motif; other site
859657012789	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
859657012790	Response regulator receiver domain; Region: Response_reg; pfam00072
859657012791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657012792	active site
859657012793	phosphorylation site [posttranslational modification]
859657012794	intermolecular recognition site; other site
859657012795	dimerization interface [polypeptide binding]; other site
859657012796	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
859657012797	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
859657012798	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657012799	dimer interface [polypeptide binding]; other site
859657012800	putative CheW interface [polypeptide binding]; other site
859657012801	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
859657012802	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859657012803	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657012804	active site
859657012805	phosphorylation site [posttranslational modification]
859657012806	intermolecular recognition site; other site
859657012807	dimerization interface [polypeptide binding]; other site
859657012808	Response regulator receiver domain; Region: Response_reg; pfam00072
859657012809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657012810	active site
859657012811	phosphorylation site [posttranslational modification]
859657012812	intermolecular recognition site; other site
859657012813	dimerization interface [polypeptide binding]; other site
859657012814	Rubredoxin [Energy production and conversion]; Region: COG1773
859657012815	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
859657012816	iron binding site [ion binding]; other site
859657012817	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
859657012818	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859657012819	inhibitor-cofactor binding pocket; inhibition site
859657012820	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657012821	catalytic residue [active]
859657012822	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
859657012823	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
859657012824	dimer interface [polypeptide binding]; other site
859657012825	active site
859657012826	catalytic residue [active]
859657012827	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
859657012828	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
859657012829	Repair protein; Region: Repair_PSII; pfam04536
859657012830	Repair protein; Region: Repair_PSII; cl01535
859657012831	Flp/Fap pilin component; Region: Flp_Fap; cl01585
859657012832	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
859657012833	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
859657012834	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
859657012835	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
859657012836	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
859657012837	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859657012838	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
859657012839	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
859657012840	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
859657012841	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
859657012842	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
859657012843	ATP binding site [chemical binding]; other site
859657012844	Walker A motif; other site
859657012845	hexamer interface [polypeptide binding]; other site
859657012846	Walker B motif; other site
859657012847	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
859657012848	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859657012849	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
859657012850	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859657012851	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
859657012852	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
859657012853	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
859657012854	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
859657012855	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
859657012856	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
859657012857	Ligand binding site; other site
859657012858	Putative Catalytic site; other site
859657012859	DXD motif; other site
859657012860	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
859657012861	active site
859657012862	Methyltransferase domain; Region: Methyltransf_23; pfam13489
859657012863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657012864	S-adenosylmethionine binding site [chemical binding]; other site
859657012865	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
859657012866	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
859657012867	Ligand binding site; other site
859657012868	Putative Catalytic site; other site
859657012869	DXD motif; other site
859657012870	Predicted membrane protein [Function unknown]; Region: COG2246
859657012871	GtrA-like protein; Region: GtrA; pfam04138
859657012872	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859657012873	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
859657012874	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
859657012875	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
859657012876	putative FMN binding site [chemical binding]; other site
859657012877	NADPH bind site [chemical binding]; other site
859657012878	Predicted membrane protein [Function unknown]; Region: COG2246
859657012879	GtrA-like protein; Region: GtrA; pfam04138
859657012880	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
859657012881	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
859657012882	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
859657012883	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
859657012884	ring oligomerisation interface [polypeptide binding]; other site
859657012885	ATP/Mg binding site [chemical binding]; other site
859657012886	stacking interactions; other site
859657012887	hinge regions; other site
859657012888	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
859657012889	oligomerisation interface [polypeptide binding]; other site
859657012890	mobile loop; other site
859657012891	roof hairpin; other site
859657012892	Evidence 2b : Function of strongly homologous gene; Product type pr : putative regulator
859657012893	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
859657012894	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
859657012895	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
859657012896	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
859657012897	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
859657012898	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
859657012899	putative chaperone; Provisional; Region: PRK11678
859657012900	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
859657012901	nucleotide binding site [chemical binding]; other site
859657012902	putative NEF/HSP70 interaction site [polypeptide binding]; other site
859657012903	SBD interface [polypeptide binding]; other site
859657012904	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
859657012905	DNA-binding interface [nucleotide binding]; DNA binding site
859657012906	putative transposase OrfB; Reviewed; Region: PHA02517
859657012907	HTH-like domain; Region: HTH_21; pfam13276
859657012908	Integrase core domain; Region: rve; pfam00665
859657012909	Integrase core domain; Region: rve_3; pfam13683
859657012910	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
859657012911	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
859657012912	ATP binding site [chemical binding]; other site
859657012913	Mg++ binding site [ion binding]; other site
859657012914	motif III; other site
859657012915	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859657012916	nucleotide binding region [chemical binding]; other site
859657012917	ATP-binding site [chemical binding]; other site
859657012918	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
859657012919	putative RNA binding site [nucleotide binding]; other site
859657012920	recombination associated protein; Reviewed; Region: rdgC; PRK00321
859657012921	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
859657012922	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
859657012923	metal binding site [ion binding]; metal-binding site
859657012924	substrate binding pocket [chemical binding]; other site
859657012925	Inclusion body protein; Region: PixA; pfam12306
859657012926	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
859657012927	ApbE family; Region: ApbE; pfam02424
859657012928	FMN-binding domain; Region: FMN_bind; pfam04205
859657012929	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
859657012930	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657012931	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657012932	metal binding site [ion binding]; metal-binding site
859657012933	active site
859657012934	I-site; other site
859657012935	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859657012936	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
859657012937	putative C-terminal domain interface [polypeptide binding]; other site
859657012938	putative GSH binding site (G-site) [chemical binding]; other site
859657012939	putative dimer interface [polypeptide binding]; other site
859657012940	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
859657012941	dimer interface [polypeptide binding]; other site
859657012942	N-terminal domain interface [polypeptide binding]; other site
859657012943	putative substrate binding pocket (H-site) [chemical binding]; other site
859657012944	Cache domain; Region: Cache_1; pfam02743
859657012945	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657012946	dimerization interface [polypeptide binding]; other site
859657012947	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
859657012948	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859657012949	dimer interface [polypeptide binding]; other site
859657012950	putative CheW interface [polypeptide binding]; other site
859657012951	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
859657012952	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
859657012953	substrate binding site [chemical binding]; other site
859657012954	catalytic Zn binding site [ion binding]; other site
859657012955	NAD binding site [chemical binding]; other site
859657012956	structural Zn binding site [ion binding]; other site
859657012957	dimer interface [polypeptide binding]; other site
859657012958	S-formylglutathione hydrolase; Region: PLN02442
859657012959	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
859657012960	Evidence 2b : Function of strongly homologous gene; Product type ph : phenotype
859657012961	Evidence 2b : Function of strongly homologous gene; Product type ph : phenotype
859657012962	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
859657012963	mce related protein; Region: MCE; pfam02470
859657012964	mce related protein; Region: MCE; pfam02470
859657012965	mce related protein; Region: MCE; pfam02470
859657012966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
859657012967	Protein of unknown function (DUF330); Region: DUF330; pfam03886
859657012968	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
859657012969	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657012970	DNA-binding site [nucleotide binding]; DNA binding site
859657012971	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657012972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657012973	homodimer interface [polypeptide binding]; other site
859657012974	catalytic residue [active]
859657012975	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
859657012976	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
859657012977	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
859657012978	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
859657012979	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859657012980	Zn2+ binding site [ion binding]; other site
859657012981	Mg2+ binding site [ion binding]; other site
859657012982	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859657012983	MarR family; Region: MarR; pfam01047
859657012984	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657012985	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
859657012986	putative ligand binding site [chemical binding]; other site
859657012987	hypothetical protein; Provisional; Region: PRK07538
859657012988	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859657012989	amidase; Provisional; Region: PRK07056
859657012990	Amidase; Region: Amidase; cl11426
859657012991	PAS domain S-box; Region: sensory_box; TIGR00229
859657012992	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657012993	putative active site [active]
859657012994	heme pocket [chemical binding]; other site
859657012995	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
859657012996	GAF domain; Region: GAF; pfam01590
859657012997	PAS fold; Region: PAS; pfam00989
859657012998	PAS domain; Region: PAS; smart00091
859657012999	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657013000	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657013001	metal binding site [ion binding]; metal-binding site
859657013002	active site
859657013003	I-site; other site
859657013004	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657013005	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
859657013006	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859657013007	active site
859657013008	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
859657013009	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
859657013010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657013011	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859657013012	putative substrate translocation pore; other site
859657013013	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
859657013014	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
859657013015	putative DNA binding site [nucleotide binding]; other site
859657013016	putative homodimer interface [polypeptide binding]; other site
859657013017	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
859657013018	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
859657013019	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
859657013020	active site
859657013021	DNA binding site [nucleotide binding]
859657013022	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
859657013023	DNA binding site [nucleotide binding]
859657013024	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
859657013025	nucleotide binding site [chemical binding]; other site
859657013026	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
859657013027	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
859657013028	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
859657013029	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
859657013030	active site
859657013031	catalytic triad [active]
859657013032	oxyanion hole [active]
859657013033	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
859657013034	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
859657013035	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
859657013036	ATP-grasp domain; Region: ATP-grasp; pfam02222
859657013037	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
859657013038	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
859657013039	ATP binding site [chemical binding]; other site
859657013040	active site
859657013041	substrate binding site [chemical binding]; other site
859657013042	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
859657013043	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
859657013044	intersubunit interface [polypeptide binding]; other site
859657013045	active site
859657013046	zinc binding site [ion binding]; other site
859657013047	Na+ binding site [ion binding]; other site
859657013048	pyruvate kinase; Provisional; Region: PRK05826
859657013049	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
859657013050	domain interfaces; other site
859657013051	active site
859657013052	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
859657013053	Phosphoglycerate kinase; Region: PGK; pfam00162
859657013054	substrate binding site [chemical binding]; other site
859657013055	hinge regions; other site
859657013056	ADP binding site [chemical binding]; other site
859657013057	catalytic site [active]
859657013058	Predicted permeases [General function prediction only]; Region: RarD; COG2962
859657013059	Predicted membrane protein [Function unknown]; Region: COG4392
859657013060	AzlC protein; Region: AzlC; pfam03591
859657013061	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
859657013062	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
859657013063	homodimer interface [polypeptide binding]; other site
859657013064	substrate-cofactor binding pocket; other site
859657013065	catalytic residue [active]
859657013066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
859657013067	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
859657013068	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
859657013069	putative active site [active]
859657013070	SnoaL-like domain; Region: SnoaL_3; pfam13474
859657013071	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
859657013072	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
859657013073	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
859657013074	Peptidase family M48; Region: Peptidase_M48; pfam01435
859657013075	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
859657013076	trimer interface [polypeptide binding]; other site
859657013077	dimer interface [polypeptide binding]; other site
859657013078	putative active site [active]
859657013079	O-Antigen ligase; Region: Wzy_C; pfam04932
859657013080	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
859657013081	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
859657013082	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
859657013083	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859657013084	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
859657013085	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
859657013086	Pilin (bacterial filament); Region: Pilin; pfam00114
859657013087	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
859657013088	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
859657013089	CoA binding domain; Region: CoA_binding; smart00881
859657013090	CoA-ligase; Region: Ligase_CoA; pfam00549
859657013091	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
859657013092	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
859657013093	CoA-ligase; Region: Ligase_CoA; pfam00549
859657013094	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
859657013095	RecX family; Region: RecX; cl00936
859657013096	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
859657013097	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
859657013098	hexamer interface [polypeptide binding]; other site
859657013099	Walker A motif; other site
859657013100	ATP binding site [chemical binding]; other site
859657013101	Walker B motif; other site
859657013102	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657013103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657013104	active site
859657013105	phosphorylation site [posttranslational modification]
859657013106	intermolecular recognition site; other site
859657013107	dimerization interface [polypeptide binding]; other site
859657013108	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657013109	DNA binding site [nucleotide binding]
859657013110	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
859657013111	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657013112	HAMP domain; Region: HAMP; pfam00672
859657013113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657013114	dimer interface [polypeptide binding]; other site
859657013115	phosphorylation site [posttranslational modification]
859657013116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657013117	ATP binding site [chemical binding]; other site
859657013118	Mg2+ binding site [ion binding]; other site
859657013119	G-X-G motif; other site
859657013120	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
859657013121	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657013122	putative substrate translocation pore; other site
859657013123	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657013124	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859657013125	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859657013126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657013127	active site
859657013128	phosphorylation site [posttranslational modification]
859657013129	intermolecular recognition site; other site
859657013130	dimerization interface [polypeptide binding]; other site
859657013131	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657013132	DNA binding site [nucleotide binding]
859657013133	LysR family transcriptional regulator; Provisional; Region: PRK14997
859657013134	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657013135	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657013136	putative effector binding pocket; other site
859657013137	dimerization interface [polypeptide binding]; other site
859657013138	Pirin-related protein [General function prediction only]; Region: COG1741
859657013139	Pirin; Region: Pirin; pfam02678
859657013140	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
859657013141	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
859657013142	serine/threonine protein kinase; Provisional; Region: PRK11768
859657013143	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
859657013144	DEAD-like helicases superfamily; Region: DEXDc; smart00487
859657013145	ATP binding site [chemical binding]; other site
859657013146	Mg++ binding site [ion binding]; other site
859657013147	motif III; other site
859657013148	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859657013149	nucleotide binding region [chemical binding]; other site
859657013150	ATP-binding site [chemical binding]; other site
859657013151	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657013152	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657013153	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
859657013154	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859657013155	active site
859657013156	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
859657013157	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
859657013158	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
859657013159	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657013160	NAD(P) binding site [chemical binding]; other site
859657013161	active site
859657013162	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
859657013163	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
859657013164	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
859657013165	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859657013166	dimer interface [polypeptide binding]; other site
859657013167	active site
859657013168	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
859657013169	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657013170	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
859657013171	acyl-activating enzyme (AAE) consensus motif; other site
859657013172	putative AMP binding site [chemical binding]; other site
859657013173	putative active site [active]
859657013174	putative CoA binding site [chemical binding]; other site
859657013175	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
859657013176	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
859657013177	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
859657013178	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859657013179	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
859657013180	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
859657013181	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657013182	FeS/SAM binding site; other site
859657013183	TRAM domain; Region: TRAM; pfam01938
859657013184	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
859657013185	PhoH-like protein; Region: PhoH; pfam02562
859657013186	unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963
859657013187	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
859657013188	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
859657013189	Transporter associated domain; Region: CorC_HlyC; smart01091
859657013190	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
859657013191	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
859657013192	putative active site [active]
859657013193	catalytic triad [active]
859657013194	putative dimer interface [polypeptide binding]; other site
859657013195	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
859657013196	dimer interface [polypeptide binding]; other site
859657013197	motif 1; other site
859657013198	active site
859657013199	motif 2; other site
859657013200	motif 3; other site
859657013201	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
859657013202	DALR anticodon binding domain; Region: DALR_1; pfam05746
859657013203	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
859657013204	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859657013205	active site
859657013206	motif I; other site
859657013207	motif II; other site
859657013208	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
859657013209	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
859657013210	putative acyl-acceptor binding pocket; other site
859657013211	Protein of unknown function DUF45; Region: DUF45; pfam01863
859657013212	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859657013213	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
859657013214	dimer interface [polypeptide binding]; other site
859657013215	active site
859657013216	metal binding site [ion binding]; metal-binding site
859657013217	glutathione binding site [chemical binding]; other site
859657013218	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
859657013219	EamA-like transporter family; Region: EamA; pfam00892
859657013220	EamA-like transporter family; Region: EamA; pfam00892
859657013221	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
859657013222	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
859657013223	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909
859657013224	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
859657013225	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
859657013226	SurA N-terminal domain; Region: SurA_N; pfam09312
859657013227	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
859657013228	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
859657013229	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
859657013230	OstA-like protein; Region: OstA; cl00844
859657013231	Organic solvent tolerance protein; Region: OstA_C; pfam04453
859657013232	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
859657013233	Phosphotransferase enzyme family; Region: APH; pfam01636
859657013234	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
859657013235	Predicted membrane protein [Function unknown]; Region: COG4392
859657013236	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
859657013237	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
859657013238	Substrate binding site; other site
859657013239	metal-binding site
859657013240	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
859657013241	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
859657013242	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
859657013243	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657013244	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657013245	metal binding site [ion binding]; metal-binding site
859657013246	active site
859657013247	I-site; other site
859657013248	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859657013249	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
859657013250	proline aminopeptidase P II; Provisional; Region: PRK10879
859657013251	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
859657013252	active site
859657013253	hypothetical protein; Provisional; Region: PRK06996
859657013254	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859657013255	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
859657013256	hydroxyglutarate oxidase; Provisional; Region: PRK11728
859657013257	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
859657013258	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
859657013259	FMN binding site [chemical binding]; other site
859657013260	active site
859657013261	catalytic residues [active]
859657013262	substrate binding site [chemical binding]; other site
859657013263	DNA-binding protein Fis; Provisional; Region: PRK01905
859657013264	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
859657013265	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
859657013266	purine monophosphate binding site [chemical binding]; other site
859657013267	dimer interface [polypeptide binding]; other site
859657013268	putative catalytic residues [active]
859657013269	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
859657013270	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
859657013271	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
859657013272	active site
859657013273	putative DNA-binding cleft [nucleotide binding]; other site
859657013274	dimer interface [polypeptide binding]; other site
859657013275	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
859657013276	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
859657013277	putative active site [active]
859657013278	catalytic site [active]
859657013279	putative metal binding site [ion binding]; other site
859657013280	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
859657013281	RuvA N terminal domain; Region: RuvA_N; pfam01330
859657013282	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
859657013283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657013284	Walker A motif; other site
859657013285	ATP binding site [chemical binding]; other site
859657013286	Walker B motif; other site
859657013287	arginine finger; other site
859657013288	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
859657013289	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
859657013290	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
859657013291	catalytic core [active]
859657013292	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
859657013293	substrate binding site [chemical binding]; other site
859657013294	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
859657013295	putative active site [active]
859657013296	dimerization interface [polypeptide binding]; other site
859657013297	putative tRNAtyr binding site [nucleotide binding]; other site
859657013298	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
859657013299	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
859657013300	active site
859657013301	HIGH motif; other site
859657013302	dimer interface [polypeptide binding]; other site
859657013303	KMSKS motif; other site
859657013304	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859657013305	RNA binding surface [nucleotide binding]; other site
859657013306	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
859657013307	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
859657013308	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
859657013309	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
859657013310	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
859657013311	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
859657013312	23S rRNA interface [nucleotide binding]; other site
859657013313	L3 interface [polypeptide binding]; other site
859657013314	OsmC-like protein; Region: OsmC; cl00767
859657013315	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
859657013316	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
859657013317	active site
859657013318	substrate binding pocket [chemical binding]; other site
859657013319	dimer interface [polypeptide binding]; other site
859657013320	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
859657013321	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
859657013322	MOFRL family; Region: MOFRL; pfam05161
859657013323	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
859657013324	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
859657013325	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
859657013326	putative active site [active]
859657013327	putative dimer interface [polypeptide binding]; other site
859657013328	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
859657013329	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859657013330	Walker A/P-loop; other site
859657013331	ATP binding site [chemical binding]; other site
859657013332	Q-loop/lid; other site
859657013333	ABC transporter signature motif; other site
859657013334	Walker B; other site
859657013335	D-loop; other site
859657013336	H-loop/switch region; other site
859657013337	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859657013338	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657013339	dimer interface [polypeptide binding]; other site
859657013340	conserved gate region; other site
859657013341	putative PBP binding loops; other site
859657013342	ABC-ATPase subunit interface; other site
859657013343	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859657013344	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657013345	dimer interface [polypeptide binding]; other site
859657013346	conserved gate region; other site
859657013347	putative PBP binding loops; other site
859657013348	ABC-ATPase subunit interface; other site
859657013349	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657013350	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859657013351	substrate binding pocket [chemical binding]; other site
859657013352	membrane-bound complex binding site; other site
859657013353	hinge residues; other site
859657013354	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
859657013355	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
859657013356	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
859657013357	NAD(P) binding site [chemical binding]; other site
859657013358	cell density-dependent motility repressor; Provisional; Region: PRK10082
859657013359	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657013360	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
859657013361	dimerization interface [polypeptide binding]; other site
859657013362	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
859657013363	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
859657013364	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
859657013365	Walker A/P-loop; other site
859657013366	ATP binding site [chemical binding]; other site
859657013367	Q-loop/lid; other site
859657013368	ABC transporter signature motif; other site
859657013369	Walker B; other site
859657013370	D-loop; other site
859657013371	H-loop/switch region; other site
859657013372	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
859657013373	enoyl-CoA hydratase; Provisional; Region: PRK06688
859657013374	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657013375	substrate binding site [chemical binding]; other site
859657013376	oxyanion hole (OAH) forming residues; other site
859657013377	trimer interface [polypeptide binding]; other site
859657013378	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
859657013379	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859657013380	dimer interface [polypeptide binding]; other site
859657013381	active site
859657013382	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
859657013383	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
859657013384	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
859657013385	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
859657013386	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657013387	substrate binding site [chemical binding]; other site
859657013388	oxyanion hole (OAH) forming residues; other site
859657013389	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
859657013390	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
859657013391	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859657013392	active site
859657013393	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
859657013394	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657013395	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657013396	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
859657013397	Coenzyme A transferase; Region: CoA_trans; smart00882
859657013398	Coenzyme A transferase; Region: CoA_trans; cl17247
859657013399	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
859657013400	putative active site [active]
859657013401	catalytic site [active]
859657013402	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
859657013403	PLD-like domain; Region: PLDc_2; pfam13091
859657013404	putative active site [active]
859657013405	catalytic site [active]
859657013406	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
859657013407	putative catalytic site [active]
859657013408	putative metal binding site [ion binding]; other site
859657013409	putative phosphate binding site [ion binding]; other site
859657013410	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
859657013411	nudix motif; other site
859657013412	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
859657013413	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
859657013414	dimer interface [polypeptide binding]; other site
859657013415	anticodon binding site; other site
859657013416	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
859657013417	homodimer interface [polypeptide binding]; other site
859657013418	motif 1; other site
859657013419	active site
859657013420	motif 2; other site
859657013421	GAD domain; Region: GAD; pfam02938
859657013422	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
859657013423	motif 3; other site
859657013424	Uncharacterized conserved protein [Function unknown]; Region: COG2928
859657013425	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331
859657013426	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
859657013427	Na binding site [ion binding]; other site
859657013428	putative glycosylation site [posttranslational modification]; other site
859657013429	putative glycosylation site [posttranslational modification]; other site
859657013430	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
859657013431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
859657013432	S-adenosylmethionine binding site [chemical binding]; other site
859657013433	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
859657013434	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
859657013435	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
859657013436	SCP-2 sterol transfer family; Region: SCP2; pfam02036
859657013437	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
859657013438	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
859657013439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657013440	S-adenosylmethionine binding site [chemical binding]; other site
859657013441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
859657013442	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
859657013443	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
859657013444	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
859657013445	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
859657013446	HIT family signature motif; other site
859657013447	catalytic residue [active]
859657013448	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
859657013449	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
859657013450	FAD binding domain; Region: FAD_binding_4; pfam01565
859657013451	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
859657013452	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
859657013453	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
859657013454	Cysteine-rich domain; Region: CCG; pfam02754
859657013455	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
859657013456	Predicted membrane protein [Function unknown]; Region: COG1238
859657013457	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
859657013458	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
859657013459	Inward rectifier potassium channel; Region: IRK; pfam01007
859657013460	threonine dehydratase; Reviewed; Region: PRK09224
859657013461	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
859657013462	tetramer interface [polypeptide binding]; other site
859657013463	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657013464	catalytic residue [active]
859657013465	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
859657013466	putative Ile/Val binding site [chemical binding]; other site
859657013467	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
859657013468	putative Ile/Val binding site [chemical binding]; other site
859657013469	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
859657013470	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
859657013471	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
859657013472	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
859657013473	putative active site [active]
859657013474	AMP-binding domain protein; Validated; Region: PRK08315
859657013475	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657013476	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
859657013477	acyl-activating enzyme (AAE) consensus motif; other site
859657013478	acyl-activating enzyme (AAE) consensus motif; other site
859657013479	putative AMP binding site [chemical binding]; other site
859657013480	putative active site [active]
859657013481	putative CoA binding site [chemical binding]; other site
859657013482	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
859657013483	ATP-binding site [chemical binding]; other site
859657013484	Gluconate-6-phosphate binding site [chemical binding]; other site
859657013485	Shikimate kinase; Region: SKI; pfam01202
859657013486	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
859657013487	Predicted transporter component [General function prediction only]; Region: COG2391
859657013488	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
859657013489	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
859657013490	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
859657013491	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
859657013492	Ligand binding site; other site
859657013493	Putative Catalytic site; other site
859657013494	DXD motif; other site
859657013495	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
859657013496	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657013497	NAD(P) binding site [chemical binding]; other site
859657013498	active site
859657013499	acyl carrier protein; Provisional; Region: PRK09184
859657013500	Predicted membrane protein [Function unknown]; Region: COG4648
859657013501	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
859657013502	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657013503	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657013504	acyl-activating enzyme (AAE) consensus motif; other site
859657013505	AMP binding site [chemical binding]; other site
859657013506	active site
859657013507	acyl-activating enzyme (AAE) consensus motif; other site
859657013508	CoA binding site [chemical binding]; other site
859657013509	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
859657013510	active site 2 [active]
859657013511	dimer interface [polypeptide binding]; other site
859657013512	active site 1 [active]
859657013513	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
859657013514	putative acyl-acceptor binding pocket; other site
859657013515	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
859657013516	Predicted exporter [General function prediction only]; Region: COG4258
859657013517	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
859657013518	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
859657013519	NodB motif; other site
859657013520	active site
859657013521	catalytic site [active]
859657013522	metal binding site [ion binding]; metal-binding site
859657013523	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
859657013524	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
859657013525	dimer interface [polypeptide binding]; other site
859657013526	active site
859657013527	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
859657013528	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
859657013529	putative active site 1 [active]
859657013530	Restriction endonuclease; Region: Mrr_cat; pfam04471
859657013531	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
859657013532	Family description; Region: UvrD_C_2; pfam13538
859657013533	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859657013534	AAA domain; Region: AAA_21; pfam13304
859657013535	Walker A/P-loop; other site
859657013536	ATP binding site [chemical binding]; other site
859657013537	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
859657013538	putative active site [active]
859657013539	putative metal-binding site [ion binding]; other site
859657013540	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859657013541	active site
859657013542	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
859657013543	active site
859657013544	dimerization interface [polypeptide binding]; other site
859657013545	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
859657013546	AAA ATPase domain; Region: AAA_16; pfam13191
859657013547	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859657013548	HTH-like domain; Region: HTH_21; pfam13276
859657013549	Integrase core domain; Region: rve; pfam00665
859657013550	Integrase core domain; Region: rve_3; pfam13683
859657013551	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
859657013552	DNA-binding interface [nucleotide binding]; DNA binding site
859657013553	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
859657013554	Integrase core domain; Region: rve; pfam00665
859657013555	Integrase core domain; Region: rve_3; pfam13683
859657013556	Transposase; Region: HTH_Tnp_1; cl17663
859657013557	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
859657013558	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657013559	non-specific DNA binding site [nucleotide binding]; other site
859657013560	salt bridge; other site
859657013561	sequence-specific DNA binding site [nucleotide binding]; other site
859657013562	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688
859657013563	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
859657013564	DNA binding site [nucleotide binding]
859657013565	active site
859657013566	Int/Topo IB signature motif; other site
859657013567	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
859657013568	DNA binding site [nucleotide binding]
859657013569	Int/Topo IB signature motif; other site
859657013570	active site
859657013571	catalytic residues [active]
859657013572	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
859657013573	active site
859657013574	catalytic residues [active]
859657013575	DNA binding site [nucleotide binding]
859657013576	Int/Topo IB signature motif; other site
859657013577	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
859657013578	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
859657013579	dimer interface [polypeptide binding]; other site
859657013580	ssDNA binding site [nucleotide binding]; other site
859657013581	tetramer (dimer of dimers) interface [polypeptide binding]; other site
859657013582	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859657013583	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657013584	putative substrate translocation pore; other site
859657013585	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
859657013586	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
859657013587	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
859657013588	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
859657013589	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
859657013590	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
859657013591	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
859657013592	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
859657013593	PhoU domain; Region: PhoU; pfam01895
859657013594	PhoU domain; Region: PhoU; pfam01895
859657013595	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
859657013596	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859657013597	active site
859657013598	intracellular protease, PfpI family; Region: PfpI; TIGR01382
859657013599	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
859657013600	conserved cys residue [active]
859657013601	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
859657013602	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
859657013603	putative cation:proton antiport protein; Provisional; Region: PRK10669
859657013604	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
859657013605	TrkA-N domain; Region: TrkA_N; pfam02254
859657013606	TrkA-C domain; Region: TrkA_C; pfam02080
859657013607	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
859657013608	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
859657013609	putative active site [active]
859657013610	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
859657013611	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
859657013612	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
859657013613	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
859657013614	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
859657013615	OstA-like protein; Region: OstA; pfam03968
859657013616	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
859657013617	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
859657013618	Walker A/P-loop; other site
859657013619	ATP binding site [chemical binding]; other site
859657013620	Q-loop/lid; other site
859657013621	ABC transporter signature motif; other site
859657013622	Walker B; other site
859657013623	D-loop; other site
859657013624	H-loop/switch region; other site
859657013625	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
859657013626	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
859657013627	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
859657013628	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
859657013629	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
859657013630	30S subunit binding site; other site
859657013631	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
859657013632	active site
859657013633	phosphorylation site [posttranslational modification]
859657013634	HPr kinase/phosphorylase; Provisional; Region: PRK05428
859657013635	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
859657013636	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
859657013637	Hpr binding site; other site
859657013638	active site
859657013639	homohexamer subunit interaction site [polypeptide binding]; other site
859657013640	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
859657013641	AAA domain; Region: AAA_18; pfam13238
859657013642	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
859657013643	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
859657013644	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
859657013645	minor groove reading motif; other site
859657013646	helix-hairpin-helix signature motif; other site
859657013647	substrate binding pocket [chemical binding]; other site
859657013648	active site
859657013649	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
859657013650	DNA binding and oxoG recognition site [nucleotide binding]
859657013651	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
859657013652	G1 box; other site
859657013653	GTP/Mg2+ binding site [chemical binding]; other site
859657013654	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
859657013655	G2 box; other site
859657013656	Switch I region; other site
859657013657	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
859657013658	G3 box; other site
859657013659	Switch II region; other site
859657013660	GTP/Mg2+ binding site [chemical binding]; other site
859657013661	G4 box; other site
859657013662	G5 box; other site
859657013663	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
859657013664	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
859657013665	DNA binding site [nucleotide binding]
859657013666	catalytic residue [active]
859657013667	H2TH interface [polypeptide binding]; other site
859657013668	putative catalytic residues [active]
859657013669	turnover-facilitating residue; other site
859657013670	intercalation triad [nucleotide binding]; other site
859657013671	8OG recognition residue [nucleotide binding]; other site
859657013672	putative reading head residues; other site
859657013673	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
859657013674	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
859657013675	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
859657013676	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657013677	binding surface
859657013678	TPR motif; other site
859657013679	Tetratricopeptide repeat; Region: TPR_16; pfam13432
859657013680	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
859657013681	binding surface
859657013682	TPR motif; other site
859657013683	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
859657013684	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859657013685	binding surface
859657013686	TPR motif; other site
859657013687	Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017
859657013688	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
859657013689	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
859657013690	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
859657013691	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
859657013692	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
859657013693	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
859657013694	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859657013695	active site
859657013696	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
859657013697	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
859657013698	5S rRNA interface [nucleotide binding]; other site
859657013699	CTC domain interface [polypeptide binding]; other site
859657013700	L16 interface [polypeptide binding]; other site
859657013701	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
859657013702	putative active site [active]
859657013703	catalytic residue [active]
859657013704	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
859657013705	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
859657013706	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
859657013707	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
859657013708	active site
859657013709	(T/H)XGH motif; other site
859657013710	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
859657013711	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657013712	S-adenosylmethionine binding site [chemical binding]; other site
859657013713	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
859657013714	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
859657013715	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
859657013716	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
859657013717	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
859657013718	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
859657013719	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
859657013720	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
859657013721	Lysine efflux permease [General function prediction only]; Region: COG1279
859657013722	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
859657013723	maleylacetoacetate isomerase; Region: maiA; TIGR01262
859657013724	C-terminal domain interface [polypeptide binding]; other site
859657013725	GSH binding site (G-site) [chemical binding]; other site
859657013726	putative dimer interface [polypeptide binding]; other site
859657013727	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
859657013728	dimer interface [polypeptide binding]; other site
859657013729	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
859657013730	N-terminal domain interface [polypeptide binding]; other site
859657013731	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
859657013732	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
859657013733	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
859657013734	ANTAR domain; Region: ANTAR; pfam03861
859657013735	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
859657013736	NMT1-like family; Region: NMT1_2; pfam13379
859657013737	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
859657013738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859657013739	dimer interface [polypeptide binding]; other site
859657013740	conserved gate region; other site
859657013741	putative PBP binding loops; other site
859657013742	ABC-ATPase subunit interface; other site
859657013743	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
859657013744	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
859657013745	Walker A/P-loop; other site
859657013746	ATP binding site [chemical binding]; other site
859657013747	Q-loop/lid; other site
859657013748	ABC transporter signature motif; other site
859657013749	Walker B; other site
859657013750	D-loop; other site
859657013751	H-loop/switch region; other site
859657013752	glycosyl transferase family protein; Provisional; Region: PRK08136
859657013753	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
859657013754	Pirin-related protein [General function prediction only]; Region: COG1741
859657013755	Pirin; Region: Pirin; pfam02678
859657013756	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
859657013757	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
859657013758	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
859657013759	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859657013760	putative active site [active]
859657013761	heme pocket [chemical binding]; other site
859657013762	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
859657013763	putative active site [active]
859657013764	heme pocket [chemical binding]; other site
859657013765	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859657013766	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859657013767	metal binding site [ion binding]; metal-binding site
859657013768	active site
859657013769	I-site; other site
859657013770	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
859657013771	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
859657013772	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657013773	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657013774	DNA binding residues [nucleotide binding]
859657013775	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
859657013776	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
859657013777	Cu(I) binding site [ion binding]; other site
859657013778	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
859657013779	UbiA prenyltransferase family; Region: UbiA; pfam01040
859657013780	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
859657013781	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
859657013782	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
859657013783	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
859657013784	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
859657013785	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
859657013786	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
859657013787	Subunit III/VIIa interface [polypeptide binding]; other site
859657013788	Phospholipid binding site [chemical binding]; other site
859657013789	Subunit I/III interface [polypeptide binding]; other site
859657013790	Subunit III/VIb interface [polypeptide binding]; other site
859657013791	Subunit III/VIa interface; other site
859657013792	Subunit III/Vb interface [polypeptide binding]; other site
859657013793	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
859657013794	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
859657013795	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
859657013796	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
859657013797	Subunit I/III interface [polypeptide binding]; other site
859657013798	D-pathway; other site
859657013799	Subunit I/VIIc interface [polypeptide binding]; other site
859657013800	Subunit I/IV interface [polypeptide binding]; other site
859657013801	Subunit I/II interface [polypeptide binding]; other site
859657013802	Low-spin heme (heme a) binding site [chemical binding]; other site
859657013803	Subunit I/VIIa interface [polypeptide binding]; other site
859657013804	Subunit I/VIa interface [polypeptide binding]; other site
859657013805	Dimer interface; other site
859657013806	Putative water exit pathway; other site
859657013807	Binuclear center (heme a3/CuB) [ion binding]; other site
859657013808	K-pathway; other site
859657013809	Subunit I/Vb interface [polypeptide binding]; other site
859657013810	Putative proton exit pathway; other site
859657013811	Subunit I/VIb interface; other site
859657013812	Subunit I/VIc interface [polypeptide binding]; other site
859657013813	Electron transfer pathway; other site
859657013814	Subunit I/VIIIb interface [polypeptide binding]; other site
859657013815	Subunit I/VIIb interface [polypeptide binding]; other site
859657013816	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
859657013817	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
859657013818	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
859657013819	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
859657013820	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
859657013821	Integral membrane protein [Function unknown]; Region: COG5488
859657013822	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
859657013823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657013824	S-adenosylmethionine binding site [chemical binding]; other site
859657013825	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
859657013826	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859657013827	active site
859657013828	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
859657013829	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
859657013830	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
859657013831	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
859657013832	preprotein translocase subunit SecB; Validated; Region: PRK05751
859657013833	SecA binding site; other site
859657013834	Preprotein binding site; other site
859657013835	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
859657013836	GSH binding site [chemical binding]; other site
859657013837	catalytic residues [active]
859657013838	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
859657013839	active site residue [active]
859657013840	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
859657013841	catalytic core [active]
859657013842	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
859657013843	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
859657013844	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
859657013845	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
859657013846	protein binding site [polypeptide binding]; other site
859657013847	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
859657013848	Catalytic dyad [active]
859657013849	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
859657013850	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
859657013851	ATP binding site [chemical binding]; other site
859657013852	substrate interface [chemical binding]; other site
859657013853	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
859657013854	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
859657013855	heme binding site [chemical binding]; other site
859657013856	ferroxidase pore; other site
859657013857	ferroxidase diiron center [ion binding]; other site
859657013858	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
859657013859	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
859657013860	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
859657013861	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
859657013862	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
859657013863	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
859657013864	dimerization domain swap beta strand [polypeptide binding]; other site
859657013865	regulatory protein interface [polypeptide binding]; other site
859657013866	active site
859657013867	regulatory phosphorylation site [posttranslational modification]; other site
859657013868	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
859657013869	active pocket/dimerization site; other site
859657013870	active site
859657013871	phosphorylation site [posttranslational modification]
859657013872	glutathione synthetase; Provisional; Region: PRK05246
859657013873	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
859657013874	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
859657013875	Glutamate-cysteine ligase; Region: GshA; pfam08886
859657013876	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
859657013877	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
859657013878	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
859657013879	Nitrogen regulatory protein P-II; Region: P-II; smart00938
859657013880	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
859657013881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
859657013882	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
859657013883	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
859657013884	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
859657013885	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
859657013886	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
859657013887	Polyphenol oxidase middle domain; Region: PPO1_DWL; pfam12142
859657013888	Protein of unknown function (DUF_B2219); Region: PPO1_KFDV; pfam12143
859657013889	LysE type translocator; Region: LysE; cl00565
859657013890	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
859657013891	putative ADP-ribose binding site [chemical binding]; other site
859657013892	putative active site [active]
859657013893	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
859657013894	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859657013895	catalytic residues [active]
859657013896	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
859657013897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657013898	active site
859657013899	phosphorylation site [posttranslational modification]
859657013900	intermolecular recognition site; other site
859657013901	dimerization interface [polypeptide binding]; other site
859657013902	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657013903	Walker A motif; other site
859657013904	ATP binding site [chemical binding]; other site
859657013905	Walker B motif; other site
859657013906	arginine finger; other site
859657013907	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859657013908	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
859657013909	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657013910	dimer interface [polypeptide binding]; other site
859657013911	phosphorylation site [posttranslational modification]
859657013912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657013913	ATP binding site [chemical binding]; other site
859657013914	Mg2+ binding site [ion binding]; other site
859657013915	G-X-G motif; other site
859657013916	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
859657013917	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
859657013918	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
859657013919	dimer interface [polypeptide binding]; other site
859657013920	[2Fe-2S] cluster binding site [ion binding]; other site
859657013921	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
859657013922	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
859657013923	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
859657013924	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
859657013925	hypothetical protein; Provisional; Region: PRK02047
859657013926	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
859657013927	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657013928	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
859657013929	dimerization interface [polypeptide binding]; other site
859657013930	substrate binding pocket [chemical binding]; other site
859657013931	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
859657013932	lipoate-protein ligase B; Provisional; Region: PRK14343
859657013933	lipoyl synthase; Provisional; Region: PRK05481
859657013934	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657013935	FeS/SAM binding site; other site
859657013936	YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849
859657013937	Evidence 4 : Homologs of previously reported genes of unknown function
859657013938	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
859657013939	Phosphoesterase family; Region: Phosphoesterase; pfam04185
859657013940	Domain of unknown function (DUF756); Region: DUF756; pfam05506
859657013941	Domain of unknown function (DUF756); Region: DUF756; pfam05506
859657013942	Predicted integral membrane protein [Function unknown]; Region: COG5652
859657013943	Protein of unknown function (DUF330); Region: DUF330; cl01135
859657013944	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
859657013945	mce related protein; Region: MCE; pfam02470
859657013946	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
859657013947	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
859657013948	Walker A/P-loop; other site
859657013949	ATP binding site [chemical binding]; other site
859657013950	Q-loop/lid; other site
859657013951	ABC transporter signature motif; other site
859657013952	Walker B; other site
859657013953	D-loop; other site
859657013954	H-loop/switch region; other site
859657013955	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
859657013956	Permease; Region: Permease; pfam02405
859657013957	biotin--protein ligase; Provisional; Region: PRK06955
859657013958	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
859657013959	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
859657013960	pantothenate kinase; Reviewed; Region: PRK13328
859657013961	Sporulation related domain; Region: SPOR; pfam05036
859657013962	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
859657013963	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
859657013964	active site
859657013965	nucleotide binding site [chemical binding]; other site
859657013966	HIGH motif; other site
859657013967	KMSKS motif; other site
859657013968	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
859657013969	dinuclear metal binding motif [ion binding]; other site
859657013970	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
859657013971	catalytic residues [active]
859657013972	dimer interface [polypeptide binding]; other site
859657013973	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
859657013974	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
859657013975	active site
859657013976	nucleophile elbow; other site
859657013977	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
859657013978	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657013979	substrate binding site [chemical binding]; other site
859657013980	oxyanion hole (OAH) forming residues; other site
859657013981	trimer interface [polypeptide binding]; other site
859657013982	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
859657013983	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859657013984	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
859657013985	putative ligand binding site [chemical binding]; other site
859657013986	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
859657013987	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859657013988	Transcriptional regulator [Transcription]; Region: IclR; COG1414
859657013989	Bacterial transcriptional regulator; Region: IclR; pfam01614
859657013990	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
859657013991	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
859657013992	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859657013993	Transcriptional regulator [Transcription]; Region: IclR; COG1414
859657013994	Bacterial transcriptional regulator; Region: IclR; pfam01614
859657013995	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
859657013996	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
859657013997	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
859657013998	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
859657013999	active site residue [active]
859657014000	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
859657014001	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
859657014002	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
859657014003	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
859657014004	substrate binding pocket [chemical binding]; other site
859657014005	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
859657014006	B12 binding site [chemical binding]; other site
859657014007	cobalt ligand [ion binding]; other site
859657014008	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
859657014009	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657014010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657014011	active site
859657014012	phosphorylation site [posttranslational modification]
859657014013	intermolecular recognition site; other site
859657014014	dimerization interface [polypeptide binding]; other site
859657014015	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657014016	DNA binding residues [nucleotide binding]
859657014017	dimerization interface [polypeptide binding]; other site
859657014018	Response regulator receiver domain; Region: Response_reg; pfam00072
859657014019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657014020	active site
859657014021	phosphorylation site [posttranslational modification]
859657014022	intermolecular recognition site; other site
859657014023	dimerization interface [polypeptide binding]; other site
859657014024	Predicted small secreted protein [Function unknown]; Region: COG5510
859657014025	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
859657014026	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657014027	Histidine kinase; Region: HisKA_3; pfam07730
859657014028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657014029	ATP binding site [chemical binding]; other site
859657014030	Mg2+ binding site [ion binding]; other site
859657014031	G-X-G motif; other site
859657014032	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
859657014033	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
859657014034	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
859657014035	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
859657014036	active site
859657014037	HIGH motif; other site
859657014038	KMSK motif region; other site
859657014039	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
859657014040	tRNA binding surface [nucleotide binding]; other site
859657014041	anticodon binding site; other site
859657014042	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
859657014043	Sporulation related domain; Region: SPOR; pfam05036
859657014044	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
859657014045	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
859657014046	catalytic residues [active]
859657014047	hinge region; other site
859657014048	alpha helical domain; other site
859657014049	short chain dehydrogenase; Provisional; Region: PRK07024
859657014050	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657014051	NAD(P) binding site [chemical binding]; other site
859657014052	active site
859657014053	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
859657014054	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
859657014055	intersubunit interface [polypeptide binding]; other site
859657014056	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
859657014057	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
859657014058	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
859657014059	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
859657014060	DNA binding residues [nucleotide binding]
859657014061	putative dimer interface [polypeptide binding]; other site
859657014062	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
859657014063	isovaleryl-CoA dehydrogenase; Region: PLN02519
859657014064	substrate binding site [chemical binding]; other site
859657014065	FAD binding site [chemical binding]; other site
859657014066	catalytic base [active]
859657014067	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
859657014068	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
859657014069	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
859657014070	active site clefts [active]
859657014071	zinc binding site [ion binding]; other site
859657014072	dimer interface [polypeptide binding]; other site
859657014073	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
859657014074	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859657014075	dimer interface [polypeptide binding]; other site
859657014076	active site
859657014077	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
859657014078	C factor cell-cell signaling protein; Provisional; Region: PRK09009
859657014079	NADP binding site [chemical binding]; other site
859657014080	homodimer interface [polypeptide binding]; other site
859657014081	active site
859657014082	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859657014083	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859657014084	active site
859657014085	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
859657014086	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
859657014087	putative catalytic residue [active]
859657014088	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
859657014089	active site
859657014090	catalytic residue [active]
859657014091	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
859657014092	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859657014093	motif II; other site
859657014094	hypothetical protein; Provisional; Region: PRK01842
859657014095	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
859657014096	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
859657014097	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
859657014098	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
859657014099	enoyl-CoA hydratase; Provisional; Region: PRK05995
859657014100	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859657014101	substrate binding site [chemical binding]; other site
859657014102	oxyanion hole (OAH) forming residues; other site
859657014103	trimer interface [polypeptide binding]; other site
859657014104	biotin synthase; Region: bioB; TIGR00433
859657014105	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859657014106	FeS/SAM binding site; other site
859657014107	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
859657014108	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
859657014109	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
859657014110	ATP-grasp domain; Region: ATP-grasp_4; cl17255
859657014111	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
859657014112	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
859657014113	carboxyltransferase (CT) interaction site; other site
859657014114	biotinylation site [posttranslational modification]; other site
859657014115	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
859657014116	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
859657014117	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
859657014118	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
859657014119	putative ligand binding site [chemical binding]; other site
859657014120	NAD binding site [chemical binding]; other site
859657014121	dimerization interface [polypeptide binding]; other site
859657014122	catalytic site [active]
859657014123	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
859657014124	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
859657014125	active site
859657014126	catalytic residues [active]
859657014127	metal binding site [ion binding]; metal-binding site
859657014128	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
859657014129	putative deacylase active site [active]
859657014130	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
859657014131	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
859657014132	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657014133	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859657014134	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859657014135	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859657014136	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859657014137	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
859657014138	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
859657014139	FMN binding site [chemical binding]; other site
859657014140	substrate binding site [chemical binding]; other site
859657014141	putative catalytic residue [active]
859657014142	Uncharacterized conserved protein [Function unknown]; Region: COG5361
859657014143	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
859657014144	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
859657014145	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859657014146	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859657014147	sequence-specific DNA binding site [nucleotide binding]; other site
859657014148	salt bridge; other site
859657014149	Cupin domain; Region: Cupin_2; pfam07883
859657014150	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859657014151	Coenzyme A binding pocket [chemical binding]; other site
859657014152	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
859657014153	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
859657014154	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
859657014155	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
859657014156	NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652
859657014157	active site
859657014158	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
859657014159	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
859657014160	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
859657014161	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657014162	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657014163	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657014164	putative effector binding pocket; other site
859657014165	dimerization interface [polypeptide binding]; other site
859657014166	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
859657014167	Isochorismatase family; Region: Isochorismatase; pfam00857
859657014168	catalytic triad [active]
859657014169	dimer interface [polypeptide binding]; other site
859657014170	conserved cis-peptide bond; other site
859657014171	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4317
859657014172	Predicted membrane protein [Function unknown]; Region: COG2259
859657014173	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
859657014174	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
859657014175	active site
859657014176	Predicted membrane protein [Function unknown]; Region: COG3619
859657014177	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
859657014178	B12 binding site [chemical binding]; other site
859657014179	cobalt ligand [ion binding]; other site
859657014180	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
859657014181	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
859657014182	Walker A; other site
859657014183	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
859657014184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
859657014185	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859657014186	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
859657014187	Predicted membrane protein [Function unknown]; Region: COG4292
859657014188	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
859657014189	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
859657014190	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
859657014191	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657014192	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657014193	homodimer interface [polypeptide binding]; other site
859657014194	catalytic residue [active]
859657014195	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
859657014196	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
859657014197	putative active site [active]
859657014198	adenylation catalytic residue [active]
859657014199	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
859657014200	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
859657014201	hypothetical protein; Reviewed; Region: PRK09588
859657014202	Probable zinc-binding domain; Region: zf-trcl; pfam13451
859657014203	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
859657014204	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
859657014205	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657014206	Walker A motif; other site
859657014207	ATP binding site [chemical binding]; other site
859657014208	Walker B motif; other site
859657014209	arginine finger; other site
859657014210	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
859657014211	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
859657014212	active site
859657014213	nucleophile elbow; other site
859657014214	Cupin domain; Region: Cupin_2; cl17218
859657014215	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
859657014216	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
859657014217	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
859657014218	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
859657014219	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
859657014220	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
859657014221	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
859657014222	Multicopper oxidase; Region: Cu-oxidase; pfam00394
859657014223	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
859657014224	Cytochrome c; Region: Cytochrom_C; pfam00034
859657014225	Uncharacterized conserved protein [Function unknown]; Region: COG1262
859657014226	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
859657014227	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
859657014228	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
859657014229	Cu(I) binding site [ion binding]; other site
859657014230	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
859657014231	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
859657014232	glutaminase active site [active]
859657014233	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
859657014234	dimer interface [polypeptide binding]; other site
859657014235	active site
859657014236	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
859657014237	dimer interface [polypeptide binding]; other site
859657014238	active site
859657014239	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
859657014240	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
859657014241	Substrate binding site; other site
859657014242	Mg++ binding site; other site
859657014243	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
859657014244	active site
859657014245	substrate binding site [chemical binding]; other site
859657014246	CoA binding site [chemical binding]; other site
859657014247	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
859657014248	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
859657014249	Ligand Binding Site [chemical binding]; other site
859657014250	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
859657014251	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
859657014252	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
859657014253	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859657014254	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
859657014255	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
859657014256	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
859657014257	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
859657014258	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
859657014259	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
859657014260	Walker A/P-loop; other site
859657014261	ATP binding site [chemical binding]; other site
859657014262	Q-loop/lid; other site
859657014263	ABC transporter signature motif; other site
859657014264	Walker B; other site
859657014265	D-loop; other site
859657014266	H-loop/switch region; other site
859657014267	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859657014268	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657014269	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657014270	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859657014271	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657014272	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
859657014273	aldehyde dehydrogenase family 7 member; Region: PLN02315
859657014274	tetrameric interface [polypeptide binding]; other site
859657014275	NAD binding site [chemical binding]; other site
859657014276	catalytic residues [active]
859657014277	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657014278	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657014279	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
859657014280	dimerization interface [polypeptide binding]; other site
859657014281	ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854
859657014282	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859657014283	inhibitor-cofactor binding pocket; inhibition site
859657014284	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657014285	catalytic residue [active]
859657014286	Arginase family; Region: Arginase; cd09989
859657014287	active site
859657014288	Mn binding site [ion binding]; other site
859657014289	oligomer interface [polypeptide binding]; other site
859657014290	Dihydroneopterin aldolase; Region: FolB; smart00905
859657014291	active site
859657014292	short chain dehydrogenase; Provisional; Region: PRK09134
859657014293	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859657014294	NAD(P) binding site [chemical binding]; other site
859657014295	active site
859657014296	Uncharacterized conserved protein [Function unknown]; Region: COG1565
859657014297	muropeptide transporter; Reviewed; Region: ampG; PRK11902
859657014298	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859657014299	putative substrate translocation pore; other site
859657014300	Peptidase family M48; Region: Peptidase_M48; cl12018
859657014301	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859657014302	RHS Repeat; Region: RHS_repeat; pfam05593
859657014303	RHS Repeat; Region: RHS_repeat; pfam05593
859657014304	RHS Repeat; Region: RHS_repeat; pfam05593
859657014305	RHS Repeat; Region: RHS_repeat; cl11982
859657014306	RHS Repeat; Region: RHS_repeat; pfam05593
859657014307	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
859657014308	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859657014309	RHS Repeat; Region: RHS_repeat; pfam05593
859657014310	RHS Repeat; Region: RHS_repeat; pfam05593
859657014311	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859657014312	EamA-like transporter family; Region: EamA; pfam00892
859657014313	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
859657014314	putative FMN binding site [chemical binding]; other site
859657014315	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859657014316	MarR family; Region: MarR; pfam01047
859657014317	Uncharacterized conserved protein [Function unknown]; Region: COG1434
859657014318	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
859657014319	putative active site [active]
859657014320	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
859657014321	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cd02106
859657014322	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657014323	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657014324	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461
859657014325	putative substrate binding pocket [chemical binding]; other site
859657014326	putative dimerization interface [polypeptide binding]; other site
859657014327	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
859657014328	putative hydrophobic ligand binding site [chemical binding]; other site
859657014329	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
859657014330	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
859657014331	Predicted membrane protein [Function unknown]; Region: COG4682
859657014332	yiaA/B two helix domain; Region: YiaAB; pfam05360
859657014333	yiaA/B two helix domain; Region: YiaAB; pfam05360
859657014334	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
859657014335	putative active site [active]
859657014336	putative catalytic site [active]
859657014337	putative DNA binding site [nucleotide binding]; other site
859657014338	putative phosphate binding site [ion binding]; other site
859657014339	metal binding site A [ion binding]; metal-binding site
859657014340	putative AP binding site [nucleotide binding]; other site
859657014341	putative metal binding site B [ion binding]; other site
859657014342	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859657014343	active site
859657014344	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
859657014345	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
859657014346	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
859657014347	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
859657014348	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
859657014349	putative acyl-acceptor binding pocket; other site
859657014350	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
859657014351	putative acyl-acceptor binding pocket; other site
859657014352	S-adenosylmethionine synthetase; Validated; Region: PRK05250
859657014353	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
859657014354	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
859657014355	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
859657014356	Uncharacterized conserved protein [Function unknown]; Region: COG4274
859657014357	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859657014358	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859657014359	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
859657014360	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
859657014361	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
859657014362	active site
859657014363	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
859657014364	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
859657014365	HPP family; Region: HPP; pfam04982
859657014366	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
859657014367	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
859657014368	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859657014369	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
859657014370	C-terminal domain interface [polypeptide binding]; other site
859657014371	GSH binding site (G-site) [chemical binding]; other site
859657014372	dimer interface [polypeptide binding]; other site
859657014373	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
859657014374	N-terminal domain interface [polypeptide binding]; other site
859657014375	dimer interface [polypeptide binding]; other site
859657014376	putative substrate binding pocket (H-site) [chemical binding]; other site
859657014377	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
859657014378	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859657014379	putative DNA binding site [nucleotide binding]; other site
859657014380	putative Zn2+ binding site [ion binding]; other site
859657014381	AsnC family; Region: AsnC_trans_reg; pfam01037
859657014382	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
859657014383	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657014384	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657014385	DNA binding residues [nucleotide binding]
859657014386	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
859657014387	Uncharacterized conserved protein [Function unknown]; Region: COG2128
859657014388	Uncharacterized conserved protein [Function unknown]; Region: COG3391
859657014389	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
859657014390	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
859657014391	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
859657014392	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657014393	substrate binding pocket [chemical binding]; other site
859657014394	membrane-bound complex binding site; other site
859657014395	hinge residues; other site
859657014396	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859657014397	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859657014398	active site
859657014399	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
859657014400	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
859657014401	Coenzyme A binding pocket [chemical binding]; other site
859657014402	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
859657014403	Phage Tail Collar Domain; Region: Collar; pfam07484
859657014404	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
859657014405	Phage Tail Collar Domain; Region: Collar; pfam07484
859657014406	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
859657014407	Phage Tail Collar Domain; Region: Collar; pfam07484
859657014408	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
859657014409	Autotransporter beta-domain; Region: Autotransporter; pfam03797
859657014410	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
859657014411	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
859657014412	FMN binding site [chemical binding]; other site
859657014413	substrate binding site [chemical binding]; other site
859657014414	putative catalytic residue [active]
859657014415	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
859657014416	ThiC-associated domain; Region: ThiC-associated; pfam13667
859657014417	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
859657014418	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
859657014419	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
859657014420	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
859657014421	thiS-thiF/thiG interaction site; other site
859657014422	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
859657014423	ThiS interaction site; other site
859657014424	putative active site [active]
859657014425	tetramer interface [polypeptide binding]; other site
859657014426	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
859657014427	thiamine phosphate binding site [chemical binding]; other site
859657014428	active site
859657014429	pyrophosphate binding site [ion binding]; other site
859657014430	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
859657014431	putative dimer interface [polypeptide binding]; other site
859657014432	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859657014433	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
859657014434	dimer interface [polypeptide binding]; other site
859657014435	substrate binding site [chemical binding]; other site
859657014436	ATP binding site [chemical binding]; other site
859657014437	Alkaline phosphatase homologues; Region: alkPPc; smart00098
859657014438	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
859657014439	active site
859657014440	dimer interface [polypeptide binding]; other site
859657014441	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
859657014442	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
859657014443	dimer interface [polypeptide binding]; other site
859657014444	active site
859657014445	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
859657014446	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
859657014447	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
859657014448	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
859657014449	homotetramer interface [polypeptide binding]; other site
859657014450	ligand binding site [chemical binding]; other site
859657014451	catalytic site [active]
859657014452	NAD binding site [chemical binding]; other site
859657014453	Membrane protein of unknown function; Region: DUF360; cl00850
859657014454	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
859657014455	FAD binding site [chemical binding]; other site
859657014456	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
859657014457	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
859657014458	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
859657014459	lytic murein transglycosylase; Provisional; Region: PRK11619
859657014460	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859657014461	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859657014462	catalytic residue [active]
859657014463	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
859657014464	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
859657014465	putative NAD(P) binding site [chemical binding]; other site
859657014466	active site
859657014467	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
859657014468	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859657014469	putative C-terminal domain interface [polypeptide binding]; other site
859657014470	putative GSH binding site (G-site) [chemical binding]; other site
859657014471	putative dimer interface [polypeptide binding]; other site
859657014472	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
859657014473	putative N-terminal domain interface [polypeptide binding]; other site
859657014474	putative dimer interface [polypeptide binding]; other site
859657014475	putative substrate binding pocket (H-site) [chemical binding]; other site
859657014476	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
859657014477	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
859657014478	active site
859657014479	NTP binding site [chemical binding]; other site
859657014480	metal binding triad [ion binding]; metal-binding site
859657014481	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
859657014482	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859657014483	Zn2+ binding site [ion binding]; other site
859657014484	Mg2+ binding site [ion binding]; other site
859657014485	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
859657014486	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859657014487	substrate binding pocket [chemical binding]; other site
859657014488	membrane-bound complex binding site; other site
859657014489	hinge residues; other site
859657014490	Uncharacterized conserved protein [Function unknown]; Region: COG3246
859657014491	hypothetical protein; Provisional; Region: PRK07483
859657014492	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859657014493	inhibitor-cofactor binding pocket; inhibition site
859657014494	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657014495	catalytic residue [active]
859657014496	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
859657014497	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
859657014498	putative active site [active]
859657014499	Response regulator receiver domain; Region: Response_reg; pfam00072
859657014500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657014501	active site
859657014502	phosphorylation site [posttranslational modification]
859657014503	intermolecular recognition site; other site
859657014504	dimerization interface [polypeptide binding]; other site
859657014505	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
859657014506	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
859657014507	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859657014508	dimerization interface [polypeptide binding]; other site
859657014509	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859657014510	dimer interface [polypeptide binding]; other site
859657014511	phosphorylation site [posttranslational modification]
859657014512	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657014513	ATP binding site [chemical binding]; other site
859657014514	Mg2+ binding site [ion binding]; other site
859657014515	G-X-G motif; other site
859657014516	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
859657014517	16S rRNA methyltransferase B; Provisional; Region: PRK10901
859657014518	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
859657014519	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657014520	S-adenosylmethionine binding site [chemical binding]; other site
859657014521	M48 family peptidase; Provisional; Region: PRK03001
859657014522	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
859657014523	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
859657014524	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
859657014525	putative active site [active]
859657014526	substrate binding site [chemical binding]; other site
859657014527	putative cosubstrate binding site; other site
859657014528	catalytic site [active]
859657014529	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
859657014530	substrate binding site [chemical binding]; other site
859657014531	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
859657014532	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
859657014533	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
859657014534	active site
859657014535	catalytic residues [active]
859657014536	metal binding site [ion binding]; metal-binding site
859657014537	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859657014538	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
859657014539	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
859657014540	DNA protecting protein DprA; Region: dprA; TIGR00732
859657014541	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
859657014542	catalytic residues [active]
859657014543	DNA topoisomerase III; Validated; Region: PRK08173
859657014544	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
859657014545	active site
859657014546	putative interdomain interaction site [polypeptide binding]; other site
859657014547	putative metal-binding site [ion binding]; other site
859657014548	putative nucleotide binding site [chemical binding]; other site
859657014549	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
859657014550	domain I; other site
859657014551	DNA binding groove [nucleotide binding]
859657014552	phosphate binding site [ion binding]; other site
859657014553	domain II; other site
859657014554	domain III; other site
859657014555	nucleotide binding site [chemical binding]; other site
859657014556	catalytic site [active]
859657014557	domain IV; other site
859657014558	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
859657014559	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
859657014560	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859657014561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859657014562	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859657014563	putative effector binding pocket; other site
859657014564	dimerization interface [polypeptide binding]; other site
859657014565	acyl-CoA synthetase; Validated; Region: PRK06178
859657014566	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657014567	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859657014568	acyl-activating enzyme (AAE) consensus motif; other site
859657014569	acyl-activating enzyme (AAE) consensus motif; other site
859657014570	AMP binding site [chemical binding]; other site
859657014571	active site
859657014572	CoA binding site [chemical binding]; other site
859657014573	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
859657014574	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
859657014575	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
859657014576	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
859657014577	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
859657014578	rod shape-determining protein MreC; Provisional; Region: PRK13922
859657014579	rod shape-determining protein MreC; Region: MreC; pfam04085
859657014580	rod shape-determining protein MreB; Provisional; Region: PRK13927
859657014581	MreB and similar proteins; Region: MreB_like; cd10225
859657014582	nucleotide binding site [chemical binding]; other site
859657014583	Mg binding site [ion binding]; other site
859657014584	putative protofilament interaction site [polypeptide binding]; other site
859657014585	RodZ interaction site [polypeptide binding]; other site
859657014586	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
859657014587	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
859657014588	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
859657014589	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859657014590	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
859657014591	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
859657014592	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
859657014593	GatB domain; Region: GatB_Yqey; smart00845
859657014594	Protein of unknown function, DUF484; Region: DUF484; cl17449
859657014595	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
859657014596	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
859657014597	active site
859657014598	DNA binding site [nucleotide binding]
859657014599	Int/Topo IB signature motif; other site
859657014600	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
859657014601	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
859657014602	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
859657014603	putative RNA binding site [nucleotide binding]; other site
859657014604	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657014605	S-adenosylmethionine binding site [chemical binding]; other site
859657014606	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
859657014607	FAD binding domain; Region: FAD_binding_4; pfam01565
859657014608	Berberine and berberine like; Region: BBE; pfam08031
859657014609	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
859657014610	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
859657014611	metal binding site 2 [ion binding]; metal-binding site
859657014612	putative DNA binding helix; other site
859657014613	metal binding site 1 [ion binding]; metal-binding site
859657014614	dimer interface [polypeptide binding]; other site
859657014615	structural Zn2+ binding site [ion binding]; other site
859657014616	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
859657014617	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
859657014618	P-loop, Walker A motif; other site
859657014619	Base recognition motif; other site
859657014620	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
859657014621	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
859657014622	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
859657014623	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
859657014624	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
859657014625	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
859657014626	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
859657014627	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
859657014628	active site
859657014629	HslU subunit interaction site [polypeptide binding]; other site
859657014630	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
859657014631	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859657014632	Walker A motif; other site
859657014633	ATP binding site [chemical binding]; other site
859657014634	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
859657014635	Walker B motif; other site
859657014636	arginine finger; other site
859657014637	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
859657014638	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
859657014639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657014640	active site
859657014641	phosphorylation site [posttranslational modification]
859657014642	intermolecular recognition site; other site
859657014643	dimerization interface [polypeptide binding]; other site
859657014644	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859657014645	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859657014646	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657014647	ATP binding site [chemical binding]; other site
859657014648	Mg2+ binding site [ion binding]; other site
859657014649	G-X-G motif; other site
859657014650	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
859657014651	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
859657014652	Putative zinc-finger; Region: zf-HC2; pfam13490
859657014653	RNA polymerase sigma factor; Provisional; Region: PRK12520
859657014654	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859657014655	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859657014656	DNA binding residues [nucleotide binding]
859657014657	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
859657014658	feedback inhibition sensing region; other site
859657014659	homohexameric interface [polypeptide binding]; other site
859657014660	nucleotide binding site [chemical binding]; other site
859657014661	N-acetyl-L-glutamate binding site [chemical binding]; other site
859657014662	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
859657014663	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
859657014664	division inhibitor protein; Provisional; Region: slmA; PRK09480
859657014665	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657014666	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
859657014667	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859657014668	DNA-binding site [nucleotide binding]; DNA binding site
859657014669	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859657014670	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657014671	homodimer interface [polypeptide binding]; other site
859657014672	catalytic residue [active]
859657014673	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
859657014674	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859657014675	inhibitor-cofactor binding pocket; inhibition site
859657014676	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859657014677	catalytic residue [active]
859657014678	succinic semialdehyde dehydrogenase; Region: PLN02278
859657014679	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
859657014680	tetramerization interface [polypeptide binding]; other site
859657014681	NAD(P) binding site [chemical binding]; other site
859657014682	catalytic residues [active]
859657014683	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
859657014684	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
859657014685	Methyltransferase domain; Region: Methyltransf_23; pfam13489
859657014686	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859657014687	S-adenosylmethionine binding site [chemical binding]; other site
859657014688	phasin family protein; Region: phasin; TIGR01841
859657014689	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
859657014690	Sel1-like repeats; Region: SEL1; smart00671
859657014691	Sel1-like repeats; Region: SEL1; smart00671
859657014692	Sel1 repeat; Region: Sel1; pfam08238
859657014693	Sel1 repeat; Region: Sel1; cl02723
859657014694	Protein of unknown function (DUF466); Region: DUF466; pfam04328
859657014695	carbon starvation protein A; Provisional; Region: PRK15015
859657014696	Carbon starvation protein CstA; Region: CstA; pfam02554
859657014697	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
859657014698	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
859657014699	Cache domain; Region: Cache_2; pfam08269
859657014700	Histidine kinase; Region: HisKA_3; pfam07730
859657014701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859657014702	ATP binding site [chemical binding]; other site
859657014703	Mg2+ binding site [ion binding]; other site
859657014704	G-X-G motif; other site
859657014705	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859657014706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657014707	active site
859657014708	phosphorylation site [posttranslational modification]
859657014709	intermolecular recognition site; other site
859657014710	dimerization interface [polypeptide binding]; other site
859657014711	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859657014712	DNA binding residues [nucleotide binding]
859657014713	dimerization interface [polypeptide binding]; other site
859657014714	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
859657014715	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
859657014716	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
859657014717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859657014718	active site
859657014719	phosphorylation site [posttranslational modification]
859657014720	intermolecular recognition site; other site
859657014721	dimerization interface [polypeptide binding]; other site
859657014722	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859657014723	DNA binding site [nucleotide binding]
859657014724	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
859657014725	active site
859657014726	substrate-binding site [chemical binding]; other site
859657014727	metal-binding site [ion binding]
859657014728	GTP binding site [chemical binding]; other site
859657014729	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
859657014730	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
859657014731	dimerization interface [polypeptide binding]; other site
859657014732	NAD binding site [chemical binding]; other site
859657014733	ligand binding site [chemical binding]; other site
859657014734	catalytic site [active]
859657014735	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
859657014736	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
859657014737	putative active site [active]
859657014738	metal binding site [ion binding]; metal-binding site
859657014739	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
859657014740	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859657014741	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859657014742	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
859657014743	Patatin-like phospholipase; Region: Patatin; pfam01734
859657014744	active site
859657014745	nucleophile elbow; other site
859657014746	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
859657014747	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
859657014748	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859657014749	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
859657014750	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
859657014751	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859657014752	HlyD family secretion protein; Region: HlyD_3; pfam13437
859657014753	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
859657014754	Protein export membrane protein; Region: SecD_SecF; cl14618
859657014755	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
859657014756	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
859657014757	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859657014758	HTH-like domain; Region: HTH_21; pfam13276
859657014759	Integrase core domain; Region: rve; pfam00665
859657014760	Integrase core domain; Region: rve_3; pfam13683
859657014761	Transposase; Region: HTH_Tnp_1; pfam01527
859657014762	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
859657014763	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
859657014764	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
859657014765	trmE is a tRNA modification GTPase; Region: trmE; cd04164
859657014766	G1 box; other site
859657014767	GTP/Mg2+ binding site [chemical binding]; other site
859657014768	Switch I region; other site
859657014769	G2 box; other site
859657014770	Switch II region; other site
859657014771	G3 box; other site
859657014772	G4 box; other site
859657014773	G5 box; other site
859657014774	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
859657014775	membrane protein insertase; Provisional; Region: PRK01318
859657014776	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
859657014777	hypothetical protein; Validated; Region: PRK00041
859657014778	RNase P protein component [Translation, ribosomal structure and biogenesis]; Region: RnpA; COG0594
859657014779	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399