-- dump date 20140620_023937 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1286170000001 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1286170000002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170000003 putative substrate translocation pore; other site 1286170000004 lipoprotein; Provisional; Region: PRK10759 1286170000005 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1286170000006 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1286170000007 putative active site [active] 1286170000008 catalytic site [active] 1286170000009 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1286170000010 domain interface [polypeptide binding]; other site 1286170000011 putative active site [active] 1286170000012 catalytic site [active] 1286170000013 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1286170000014 CoA binding domain; Region: CoA_binding_2; pfam13380 1286170000015 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1286170000016 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1286170000017 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286170000018 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286170000019 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1286170000020 thioredoxin 2; Provisional; Region: PRK10996 1286170000021 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1286170000022 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286170000023 catalytic residues [active] 1286170000024 putative methyltransferase; Provisional; Region: PRK10864 1286170000025 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1286170000026 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1286170000027 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1286170000028 ligand binding site [chemical binding]; other site 1286170000029 active site 1286170000030 UGI interface [polypeptide binding]; other site 1286170000031 catalytic site [active] 1286170000032 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1286170000033 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1286170000034 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1286170000035 ATP binding site [chemical binding]; other site 1286170000036 Mg++ binding site [ion binding]; other site 1286170000037 motif III; other site 1286170000038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170000039 nucleotide binding region [chemical binding]; other site 1286170000040 ATP-binding site [chemical binding]; other site 1286170000041 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1286170000042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170000043 S-adenosylmethionine binding site [chemical binding]; other site 1286170000044 L-aspartate oxidase; Provisional; Region: PRK09077 1286170000045 L-aspartate oxidase; Provisional; Region: PRK06175 1286170000046 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1286170000047 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1286170000048 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286170000049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286170000050 DNA binding residues [nucleotide binding] 1286170000051 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1286170000052 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1286170000053 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1286170000054 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1286170000055 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1286170000056 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1286170000057 GTP-binding protein LepA; Provisional; Region: PRK05433 1286170000058 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1286170000059 G1 box; other site 1286170000060 putative GEF interaction site [polypeptide binding]; other site 1286170000061 GTP/Mg2+ binding site [chemical binding]; other site 1286170000062 Switch I region; other site 1286170000063 G2 box; other site 1286170000064 G3 box; other site 1286170000065 Switch II region; other site 1286170000066 G4 box; other site 1286170000067 G5 box; other site 1286170000068 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1286170000069 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1286170000070 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1286170000071 signal peptidase I; Provisional; Region: PRK10861 1286170000072 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286170000073 Catalytic site [active] 1286170000074 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286170000075 ribonuclease III; Reviewed; Region: rnc; PRK00102 1286170000076 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1286170000077 dimerization interface [polypeptide binding]; other site 1286170000078 active site 1286170000079 metal binding site [ion binding]; metal-binding site 1286170000080 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1286170000081 dsRNA binding site [nucleotide binding]; other site 1286170000082 GTPase Era; Reviewed; Region: era; PRK00089 1286170000083 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1286170000084 G1 box; other site 1286170000085 GTP/Mg2+ binding site [chemical binding]; other site 1286170000086 Switch I region; other site 1286170000087 G2 box; other site 1286170000088 Switch II region; other site 1286170000089 G3 box; other site 1286170000090 G4 box; other site 1286170000091 G5 box; other site 1286170000092 KH domain; Region: KH_2; pfam07650 1286170000093 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1286170000094 Recombination protein O N terminal; Region: RecO_N; pfam11967 1286170000095 Recombination protein O C terminal; Region: RecO_C; pfam02565 1286170000096 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1286170000097 active site 1286170000098 hydrophilic channel; other site 1286170000099 dimerization interface [polypeptide binding]; other site 1286170000100 catalytic residues [active] 1286170000101 active site lid [active] 1286170000102 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1286170000103 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1286170000104 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170000105 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1286170000106 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170000107 putative active site [active] 1286170000108 hypothetical protein; Provisional; Region: PRK11590 1286170000109 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1286170000110 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1286170000111 nucleoside/Zn binding site; other site 1286170000112 dimer interface [polypeptide binding]; other site 1286170000113 catalytic motif [active] 1286170000114 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1286170000115 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170000116 substrate binding pocket [chemical binding]; other site 1286170000117 membrane-bound complex binding site; other site 1286170000118 hinge residues; other site 1286170000119 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286170000120 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286170000121 catalytic residue [active] 1286170000122 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1286170000123 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1286170000124 dimerization interface [polypeptide binding]; other site 1286170000125 ATP binding site [chemical binding]; other site 1286170000126 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1286170000127 dimerization interface [polypeptide binding]; other site 1286170000128 ATP binding site [chemical binding]; other site 1286170000129 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1286170000130 putative active site [active] 1286170000131 catalytic triad [active] 1286170000132 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286170000133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170000134 dimer interface [polypeptide binding]; other site 1286170000135 phosphorylation site [posttranslational modification] 1286170000136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170000137 ATP binding site [chemical binding]; other site 1286170000138 Mg2+ binding site [ion binding]; other site 1286170000139 G-X-G motif; other site 1286170000140 hypothetical protein; Provisional; Region: PRK10722 1286170000141 response regulator GlrR; Provisional; Region: PRK15115 1286170000142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170000143 active site 1286170000144 phosphorylation site [posttranslational modification] 1286170000145 intermolecular recognition site; other site 1286170000146 dimerization interface [polypeptide binding]; other site 1286170000147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170000148 Walker A motif; other site 1286170000149 ATP binding site [chemical binding]; other site 1286170000150 Walker B motif; other site 1286170000151 arginine finger; other site 1286170000152 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1286170000153 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1286170000154 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1286170000155 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1286170000156 heme-binding site [chemical binding]; other site 1286170000157 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1286170000158 FAD binding pocket [chemical binding]; other site 1286170000159 FAD binding motif [chemical binding]; other site 1286170000160 phosphate binding motif [ion binding]; other site 1286170000161 beta-alpha-beta structure motif; other site 1286170000162 NAD binding pocket [chemical binding]; other site 1286170000163 Heme binding pocket [chemical binding]; other site 1286170000164 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1286170000165 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1286170000166 dimer interface [polypeptide binding]; other site 1286170000167 active site 1286170000168 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1286170000169 folate binding site [chemical binding]; other site 1286170000170 Predicted membrane protein [Function unknown]; Region: COG2259 1286170000171 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1286170000172 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286170000173 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286170000174 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1286170000175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286170000176 TPR motif; other site 1286170000177 binding surface 1286170000178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286170000179 TPR motif; other site 1286170000180 TPR repeat; Region: TPR_11; pfam13414 1286170000181 binding surface 1286170000182 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286170000183 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1286170000184 ligand binding site [chemical binding]; other site 1286170000185 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170000186 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286170000187 Walker A/P-loop; other site 1286170000188 ATP binding site [chemical binding]; other site 1286170000189 Q-loop/lid; other site 1286170000190 ABC transporter signature motif; other site 1286170000191 Walker B; other site 1286170000192 D-loop; other site 1286170000193 H-loop/switch region; other site 1286170000194 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170000195 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170000196 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170000197 TM-ABC transporter signature motif; other site 1286170000198 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 1286170000199 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286170000200 putative NAD(P) binding site [chemical binding]; other site 1286170000201 catalytic Zn binding site [ion binding]; other site 1286170000202 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1286170000203 active site 1286170000204 catalytic residues [active] 1286170000205 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1286170000206 MFS_1 like family; Region: MFS_1_like; pfam12832 1286170000207 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1286170000208 PRD domain; Region: PRD; pfam00874 1286170000209 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1286170000210 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1286170000211 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286170000212 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1286170000213 active site 1286170000214 dimerization interface [polypeptide binding]; other site 1286170000215 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1286170000216 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1286170000217 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1286170000218 Rrf2 family protein; Region: rrf2_super; TIGR00738 1286170000219 cysteine desulfurase; Provisional; Region: PRK14012 1286170000220 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1286170000221 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286170000222 catalytic residue [active] 1286170000223 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1286170000224 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1286170000225 trimerization site [polypeptide binding]; other site 1286170000226 active site 1286170000227 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1286170000228 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1286170000229 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1286170000230 HSP70 interaction site [polypeptide binding]; other site 1286170000231 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1286170000232 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1286170000233 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1286170000234 nucleotide binding site [chemical binding]; other site 1286170000235 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1286170000236 SBD interface [polypeptide binding]; other site 1286170000237 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1286170000238 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286170000239 catalytic loop [active] 1286170000240 iron binding site [ion binding]; other site 1286170000241 hypothetical protein; Provisional; Region: PRK10721 1286170000242 aminopeptidase B; Provisional; Region: PRK05015 1286170000243 Peptidase; Region: DUF3663; pfam12404 1286170000244 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1286170000245 interface (dimer of trimers) [polypeptide binding]; other site 1286170000246 Substrate-binding/catalytic site; other site 1286170000247 Zn-binding sites [ion binding]; other site 1286170000248 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1286170000249 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1286170000250 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1286170000251 active site residue [active] 1286170000252 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1286170000253 active site residue [active] 1286170000254 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286170000255 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 1286170000256 metal binding site [ion binding]; metal-binding site 1286170000257 putative dimer interface [polypeptide binding]; other site 1286170000258 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1286170000259 MG2 domain; Region: A2M_N; pfam01835 1286170000260 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1286170000261 surface patch; other site 1286170000262 thioester region; other site 1286170000263 specificity defining residues; other site 1286170000264 penicillin-binding protein 1C; Provisional; Region: PRK11240 1286170000265 Transglycosylase; Region: Transgly; pfam00912 1286170000266 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1286170000267 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1286170000268 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1286170000269 active site 1286170000270 multimer interface [polypeptide binding]; other site 1286170000271 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1286170000272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170000273 FeS/SAM binding site; other site 1286170000274 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1286170000275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170000276 non-specific DNA binding site [nucleotide binding]; other site 1286170000277 salt bridge; other site 1286170000278 sequence-specific DNA binding site [nucleotide binding]; other site 1286170000279 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1286170000280 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1286170000281 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1286170000282 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1286170000283 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1286170000284 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1286170000285 dimer interface [polypeptide binding]; other site 1286170000286 motif 1; other site 1286170000287 active site 1286170000288 motif 2; other site 1286170000289 motif 3; other site 1286170000290 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1286170000291 anticodon binding site; other site 1286170000292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1286170000293 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1286170000294 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1286170000295 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1286170000296 Trp docking motif [polypeptide binding]; other site 1286170000297 GTP-binding protein Der; Reviewed; Region: PRK00093 1286170000298 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1286170000299 G1 box; other site 1286170000300 GTP/Mg2+ binding site [chemical binding]; other site 1286170000301 Switch I region; other site 1286170000302 G2 box; other site 1286170000303 Switch II region; other site 1286170000304 G3 box; other site 1286170000305 G4 box; other site 1286170000306 G5 box; other site 1286170000307 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1286170000308 G1 box; other site 1286170000309 GTP/Mg2+ binding site [chemical binding]; other site 1286170000310 Switch I region; other site 1286170000311 G2 box; other site 1286170000312 G3 box; other site 1286170000313 Switch II region; other site 1286170000314 G4 box; other site 1286170000315 G5 box; other site 1286170000316 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1286170000317 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1286170000318 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1286170000319 generic binding surface II; other site 1286170000320 generic binding surface I; other site 1286170000321 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1286170000322 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1286170000323 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1286170000324 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1286170000325 active site 1286170000326 GMP synthase; Reviewed; Region: guaA; PRK00074 1286170000327 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1286170000328 AMP/PPi binding site [chemical binding]; other site 1286170000329 candidate oxyanion hole; other site 1286170000330 catalytic triad [active] 1286170000331 potential glutamine specificity residues [chemical binding]; other site 1286170000332 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1286170000333 ATP Binding subdomain [chemical binding]; other site 1286170000334 Ligand Binding sites [chemical binding]; other site 1286170000335 Dimerization subdomain; other site 1286170000336 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1286170000337 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 1286170000338 putative active site [active] 1286170000339 catalytic triad [active] 1286170000340 putative dimer interface [polypeptide binding]; other site 1286170000341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170000342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170000343 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1286170000344 dimerization interface [polypeptide binding]; other site 1286170000345 substrate binding pocket [chemical binding]; other site 1286170000346 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170000347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170000348 putative substrate translocation pore; other site 1286170000349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170000350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170000351 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286170000352 dimerization interface [polypeptide binding]; other site 1286170000353 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1286170000354 MASE1; Region: MASE1; pfam05231 1286170000355 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170000356 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1286170000357 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170000358 exopolyphosphatase; Provisional; Region: PRK10854 1286170000359 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1286170000360 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1286170000361 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1286170000362 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1286170000363 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 1286170000364 domain interface [polypeptide binding]; other site 1286170000365 active site 1286170000366 catalytic site [active] 1286170000367 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1286170000368 domain interface [polypeptide binding]; other site 1286170000369 active site 1286170000370 catalytic site [active] 1286170000371 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1286170000372 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1286170000373 active site 1286170000374 substrate binding site [chemical binding]; other site 1286170000375 cosubstrate binding site; other site 1286170000376 catalytic site [active] 1286170000377 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1286170000378 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1286170000379 dimerization interface [polypeptide binding]; other site 1286170000380 putative ATP binding site [chemical binding]; other site 1286170000381 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286170000382 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286170000383 nucleotide binding site [chemical binding]; other site 1286170000384 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 1286170000385 beta-galactosidase; Region: BGL; TIGR03356 1286170000386 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286170000387 active site 1286170000388 uracil transporter; Provisional; Region: PRK10720 1286170000389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1286170000390 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1286170000391 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1286170000392 ArsC family; Region: ArsC; pfam03960 1286170000393 catalytic residues [active] 1286170000394 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1286170000395 Peptidase family M48; Region: Peptidase_M48; cl12018 1286170000396 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286170000397 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286170000398 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1286170000399 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286170000400 catalytic triad [active] 1286170000401 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1286170000402 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1286170000403 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1286170000404 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1286170000405 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1286170000406 dimer interface [polypeptide binding]; other site 1286170000407 active site 1286170000408 catalytic residue [active] 1286170000409 lipoprotein; Provisional; Region: PRK11679 1286170000410 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1286170000411 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1286170000412 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1286170000413 ATP binding site [chemical binding]; other site 1286170000414 active site 1286170000415 substrate binding site [chemical binding]; other site 1286170000416 Predicted metalloprotease [General function prediction only]; Region: COG2321 1286170000417 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1286170000418 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1286170000419 Helicase; Region: Helicase_RecD; pfam05127 1286170000420 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1286170000421 putative hydrolase; Provisional; Region: PRK11460 1286170000422 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1286170000423 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 1286170000424 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1286170000425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1286170000426 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1286170000427 hypothetical protein; Provisional; Region: PRK13664 1286170000428 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1286170000429 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1286170000430 metal binding site [ion binding]; metal-binding site 1286170000431 dimer interface [polypeptide binding]; other site 1286170000432 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1286170000433 ArsC family; Region: ArsC; pfam03960 1286170000434 putative catalytic residues [active] 1286170000435 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1286170000436 Protein export membrane protein; Region: SecD_SecF; cl14618 1286170000437 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1286170000438 4Fe-4S binding domain; Region: Fer4; pfam00037 1286170000439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170000440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170000441 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1286170000442 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1286170000443 dimer interface [polypeptide binding]; other site 1286170000444 ADP-ribose binding site [chemical binding]; other site 1286170000445 active site 1286170000446 nudix motif; other site 1286170000447 metal binding site [ion binding]; metal-binding site 1286170000448 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1286170000449 transketolase; Reviewed; Region: PRK12753 1286170000450 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1286170000451 TPP-binding site [chemical binding]; other site 1286170000452 dimer interface [polypeptide binding]; other site 1286170000453 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286170000454 PYR/PP interface [polypeptide binding]; other site 1286170000455 dimer interface [polypeptide binding]; other site 1286170000456 TPP binding site [chemical binding]; other site 1286170000457 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286170000458 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1286170000459 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1286170000460 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1286170000461 putative NAD(P) binding site [chemical binding]; other site 1286170000462 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1286170000463 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1286170000464 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1286170000465 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1286170000466 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1286170000467 active site 1286170000468 metal binding site [ion binding]; metal-binding site 1286170000469 putative acetyltransferase; Provisional; Region: PRK03624 1286170000470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170000471 Coenzyme A binding pocket [chemical binding]; other site 1286170000472 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1286170000473 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1286170000474 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1286170000475 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1286170000476 thiosulfate transporter subunit; Provisional; Region: PRK10852 1286170000477 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286170000478 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1286170000479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170000480 dimer interface [polypeptide binding]; other site 1286170000481 conserved gate region; other site 1286170000482 putative PBP binding loops; other site 1286170000483 ABC-ATPase subunit interface; other site 1286170000484 sulfate transport protein; Provisional; Region: cysT; CHL00187 1286170000485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170000486 dimer interface [polypeptide binding]; other site 1286170000487 conserved gate region; other site 1286170000488 putative PBP binding loops; other site 1286170000489 ABC-ATPase subunit interface; other site 1286170000490 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1286170000491 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1286170000492 Walker A/P-loop; other site 1286170000493 ATP binding site [chemical binding]; other site 1286170000494 Q-loop/lid; other site 1286170000495 ABC transporter signature motif; other site 1286170000496 Walker B; other site 1286170000497 D-loop; other site 1286170000498 H-loop/switch region; other site 1286170000499 TOBE-like domain; Region: TOBE_3; pfam12857 1286170000500 cysteine synthase B; Region: cysM; TIGR01138 1286170000501 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1286170000502 dimer interface [polypeptide binding]; other site 1286170000503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170000504 catalytic residue [active] 1286170000505 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1286170000506 SnoaL-like domain; Region: SnoaL_3; pfam13474 1286170000507 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1286170000508 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1286170000509 catalytic triad [active] 1286170000510 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1286170000511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170000512 DNA-binding site [nucleotide binding]; DNA binding site 1286170000513 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170000514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170000515 homodimer interface [polypeptide binding]; other site 1286170000516 catalytic residue [active] 1286170000517 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1286170000518 dimer interface [polypeptide binding]; other site 1286170000519 pyridoxamine kinase; Validated; Region: PRK05756 1286170000520 pyridoxal binding site [chemical binding]; other site 1286170000521 ATP binding site [chemical binding]; other site 1286170000522 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1286170000523 HPr interaction site; other site 1286170000524 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1286170000525 active site 1286170000526 phosphorylation site [posttranslational modification] 1286170000527 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1286170000528 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1286170000529 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1286170000530 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1286170000531 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1286170000532 dimerization domain swap beta strand [polypeptide binding]; other site 1286170000533 regulatory protein interface [polypeptide binding]; other site 1286170000534 active site 1286170000535 regulatory phosphorylation site [posttranslational modification]; other site 1286170000536 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1286170000537 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1286170000538 dimer interface [polypeptide binding]; other site 1286170000539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170000540 catalytic residue [active] 1286170000541 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1286170000542 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1286170000543 cell division protein ZipA; Provisional; Region: PRK03427 1286170000544 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1286170000545 FtsZ protein binding site [polypeptide binding]; other site 1286170000546 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1286170000547 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1286170000548 nucleotide binding pocket [chemical binding]; other site 1286170000549 K-X-D-G motif; other site 1286170000550 catalytic site [active] 1286170000551 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1286170000552 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1286170000553 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1286170000554 Dimer interface [polypeptide binding]; other site 1286170000555 BRCT sequence motif; other site 1286170000556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1286170000557 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1286170000558 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1286170000559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170000560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170000561 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1286170000562 putative dimerization interface [polypeptide binding]; other site 1286170000563 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1286170000564 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1286170000565 active site 1286170000566 HIGH motif; other site 1286170000567 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1286170000568 active site 1286170000569 KMSKS motif; other site 1286170000570 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1286170000571 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1286170000572 MASE1; Region: MASE1; pfam05231 1286170000573 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170000574 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1286170000575 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170000576 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1286170000577 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1286170000578 Nucleoside recognition; Region: Gate; pfam07670 1286170000579 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1286170000580 manganese transport protein MntH; Reviewed; Region: PRK00701 1286170000581 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1286170000582 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170000583 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170000584 active site 1286170000585 catalytic tetrad [active] 1286170000586 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1286170000587 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1286170000588 dimer interface [polypeptide binding]; other site 1286170000589 PYR/PP interface [polypeptide binding]; other site 1286170000590 TPP binding site [chemical binding]; other site 1286170000591 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286170000592 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1286170000593 TPP-binding site [chemical binding]; other site 1286170000594 dimer interface [polypeptide binding]; other site 1286170000595 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1286170000596 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1286170000597 Cl- selectivity filter; other site 1286170000598 Cl- binding residues [ion binding]; other site 1286170000599 pore gating glutamate residue; other site 1286170000600 dimer interface [polypeptide binding]; other site 1286170000601 glucokinase; Provisional; Region: glk; PRK00292 1286170000602 glucokinase, proteobacterial type; Region: glk; TIGR00749 1286170000603 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1286170000604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170000605 active site 1286170000606 phosphorylation site [posttranslational modification] 1286170000607 intermolecular recognition site; other site 1286170000608 dimerization interface [polypeptide binding]; other site 1286170000609 LytTr DNA-binding domain; Region: LytTR; pfam04397 1286170000610 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1286170000611 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1286170000612 GAF domain; Region: GAF; pfam01590 1286170000613 Histidine kinase; Region: His_kinase; pfam06580 1286170000614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170000615 ATP binding site [chemical binding]; other site 1286170000616 Mg2+ binding site [ion binding]; other site 1286170000617 G-X-G motif; other site 1286170000618 aminotransferase; Validated; Region: PRK08175 1286170000619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170000620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170000621 homodimer interface [polypeptide binding]; other site 1286170000622 catalytic residue [active] 1286170000623 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1286170000624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170000625 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1286170000626 nucleoside/Zn binding site; other site 1286170000627 dimer interface [polypeptide binding]; other site 1286170000628 catalytic motif [active] 1286170000629 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1286170000630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170000631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170000632 dimerization interface [polypeptide binding]; other site 1286170000633 MltA-interacting protein MipA; Region: MipA; cl01504 1286170000634 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1286170000635 potential frameshift: common BLAST hit: gi|157370046|ref|YP_001478035.1| ImpA domain-containing protein 1286170000636 potential frameshift: common BLAST hit: gi|157370046|ref|YP_001478035.1| ImpA domain-containing protein 1286170000637 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1286170000638 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1286170000639 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1286170000640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1286170000641 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1286170000642 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286170000643 dimer interface [polypeptide binding]; other site 1286170000644 active site 1286170000645 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1286170000646 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286170000647 substrate binding site [chemical binding]; other site 1286170000648 oxyanion hole (OAH) forming residues; other site 1286170000649 trimer interface [polypeptide binding]; other site 1286170000650 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1286170000651 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286170000652 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286170000653 catalytic core [active] 1286170000654 hypothetical protein; Provisional; Region: PRK04946 1286170000655 Smr domain; Region: Smr; pfam01713 1286170000656 HemK family putative methylases; Region: hemK_fam; TIGR00536 1286170000657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170000658 S-adenosylmethionine binding site [chemical binding]; other site 1286170000659 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1286170000660 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1286170000661 Tetramer interface [polypeptide binding]; other site 1286170000662 active site 1286170000663 FMN-binding site [chemical binding]; other site 1286170000664 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1286170000665 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1286170000666 hypothetical protein; Provisional; Region: PRK10621 1286170000667 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286170000668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1286170000669 YfcL protein; Region: YfcL; pfam08891 1286170000670 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1286170000671 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1286170000672 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1286170000673 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1286170000674 dimer interface [polypeptide binding]; other site 1286170000675 active site 1286170000676 putative transporter; Provisional; Region: PRK12382 1286170000677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170000678 putative substrate translocation pore; other site 1286170000679 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286170000680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170000681 DNA-binding site [nucleotide binding]; DNA binding site 1286170000682 UTRA domain; Region: UTRA; pfam07702 1286170000683 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1286170000684 active site 1286170000685 P-loop; other site 1286170000686 phosphorylation site [posttranslational modification] 1286170000687 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1286170000688 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1286170000689 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 1286170000690 active site 1286170000691 methionine cluster; other site 1286170000692 phosphorylation site [posttranslational modification] 1286170000693 metal binding site [ion binding]; metal-binding site 1286170000694 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1286170000695 trimer interface; other site 1286170000696 sugar binding site [chemical binding]; other site 1286170000697 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1286170000698 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1286170000699 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1286170000700 ligand binding site [chemical binding]; other site 1286170000701 NAD binding site [chemical binding]; other site 1286170000702 catalytic site [active] 1286170000703 homodimer interface [polypeptide binding]; other site 1286170000704 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1286170000705 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1286170000706 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1286170000707 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1286170000708 dimerization interface 3.5A [polypeptide binding]; other site 1286170000709 active site 1286170000710 hypothetical protein; Provisional; Region: PRK10847 1286170000711 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286170000712 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1286170000713 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1286170000714 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1286170000715 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286170000716 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286170000717 cell division protein DedD; Provisional; Region: PRK11633 1286170000718 Sporulation related domain; Region: SPOR; pfam05036 1286170000719 colicin V production protein; Provisional; Region: PRK10845 1286170000720 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1286170000721 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1286170000722 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1286170000723 active site 1286170000724 tetramer interface [polypeptide binding]; other site 1286170000725 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286170000726 active site 1286170000727 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1286170000728 Flavoprotein; Region: Flavoprotein; pfam02441 1286170000729 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1286170000730 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170000731 substrate binding pocket [chemical binding]; other site 1286170000732 membrane-bound complex binding site; other site 1286170000733 hinge residues; other site 1286170000734 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1286170000735 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170000736 substrate binding pocket [chemical binding]; other site 1286170000737 membrane-bound complex binding site; other site 1286170000738 hinge residues; other site 1286170000739 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170000740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170000741 dimer interface [polypeptide binding]; other site 1286170000742 conserved gate region; other site 1286170000743 putative PBP binding loops; other site 1286170000744 ABC-ATPase subunit interface; other site 1286170000745 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170000746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170000747 dimer interface [polypeptide binding]; other site 1286170000748 conserved gate region; other site 1286170000749 putative PBP binding loops; other site 1286170000750 ABC-ATPase subunit interface; other site 1286170000751 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1286170000752 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286170000753 Walker A/P-loop; other site 1286170000754 ATP binding site [chemical binding]; other site 1286170000755 Q-loop/lid; other site 1286170000756 ABC transporter signature motif; other site 1286170000757 Walker B; other site 1286170000758 D-loop; other site 1286170000759 H-loop/switch region; other site 1286170000760 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286170000761 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286170000762 Coenzyme A binding pocket [chemical binding]; other site 1286170000763 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1286170000764 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1286170000765 putative NAD(P) binding site [chemical binding]; other site 1286170000766 putative active site [active] 1286170000767 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1286170000768 homooctamer interface [polypeptide binding]; other site 1286170000769 active site 1286170000770 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1286170000771 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1286170000772 C-terminal domain interface [polypeptide binding]; other site 1286170000773 GSH binding site (G-site) [chemical binding]; other site 1286170000774 dimer interface [polypeptide binding]; other site 1286170000775 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1286170000776 N-terminal domain interface [polypeptide binding]; other site 1286170000777 putative dimer interface [polypeptide binding]; other site 1286170000778 active site 1286170000779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170000780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170000781 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286170000782 putative effector binding pocket; other site 1286170000783 putative dimerization interface [polypeptide binding]; other site 1286170000784 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1286170000785 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286170000786 NAD binding site [chemical binding]; other site 1286170000787 catalytic residues [active] 1286170000788 glutathione S-transferase; Provisional; Region: PRK15113 1286170000789 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1286170000790 C-terminal domain interface [polypeptide binding]; other site 1286170000791 GSH binding site (G-site) [chemical binding]; other site 1286170000792 dimer interface [polypeptide binding]; other site 1286170000793 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1286170000794 N-terminal domain interface [polypeptide binding]; other site 1286170000795 putative dimer interface [polypeptide binding]; other site 1286170000796 putative substrate binding pocket (H-site) [chemical binding]; other site 1286170000797 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1286170000798 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286170000799 active site 1286170000800 metal binding site [ion binding]; metal-binding site 1286170000801 homotetramer interface [polypeptide binding]; other site 1286170000802 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1286170000803 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1286170000804 nudix motif; other site 1286170000805 phosphate acetyltransferase; Reviewed; Region: PRK05632 1286170000806 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286170000807 DRTGG domain; Region: DRTGG; pfam07085 1286170000808 phosphate acetyltransferase; Region: pta; TIGR00651 1286170000809 propionate/acetate kinase; Provisional; Region: PRK12379 1286170000810 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1286170000811 hypothetical protein; Provisional; Region: PRK01816 1286170000812 hypothetical protein; Validated; Region: PRK05445 1286170000813 putative phosphatase; Provisional; Region: PRK11587 1286170000814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170000815 active site 1286170000816 motif I; other site 1286170000817 motif II; other site 1286170000818 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1286170000819 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1286170000820 TrkA-C domain; Region: TrkA_C; pfam02080 1286170000821 TrkA-C domain; Region: TrkA_C; pfam02080 1286170000822 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1286170000823 5'-nucleotidase; Provisional; Region: PRK03826 1286170000824 aminotransferase AlaT; Validated; Region: PRK09265 1286170000825 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170000826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170000827 homodimer interface [polypeptide binding]; other site 1286170000828 catalytic residue [active] 1286170000829 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1286170000830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170000831 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1286170000832 putative dimerization interface [polypeptide binding]; other site 1286170000833 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1286170000834 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1286170000835 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1286170000836 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1286170000837 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1286170000838 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1286170000839 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1286170000840 putative dimer interface [polypeptide binding]; other site 1286170000841 [2Fe-2S] cluster binding site [ion binding]; other site 1286170000842 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1286170000843 SLBB domain; Region: SLBB; pfam10531 1286170000844 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1286170000845 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1286170000846 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286170000847 catalytic loop [active] 1286170000848 iron binding site [ion binding]; other site 1286170000849 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1286170000850 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1286170000851 [4Fe-4S] binding site [ion binding]; other site 1286170000852 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1286170000853 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1286170000854 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1286170000855 4Fe-4S binding domain; Region: Fer4; pfam00037 1286170000856 4Fe-4S binding domain; Region: Fer4; pfam00037 1286170000857 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1286170000858 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1286170000859 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1286170000860 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1286170000861 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1286170000862 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286170000863 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1286170000864 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286170000865 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1286170000866 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286170000867 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1286170000868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170000869 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1286170000870 Coenzyme A binding pocket [chemical binding]; other site 1286170000871 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1286170000872 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1286170000873 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1286170000874 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1286170000875 dimer interface [polypeptide binding]; other site 1286170000876 tetramer interface [polypeptide binding]; other site 1286170000877 PYR/PP interface [polypeptide binding]; other site 1286170000878 TPP binding site [chemical binding]; other site 1286170000879 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1286170000880 TPP-binding site; other site 1286170000881 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1286170000882 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286170000883 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1286170000884 substrate binding site [chemical binding]; other site 1286170000885 oxyanion hole (OAH) forming residues; other site 1286170000886 trimer interface [polypeptide binding]; other site 1286170000887 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1286170000888 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1286170000889 active site 1286170000890 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1286170000891 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1286170000892 acyl-activating enzyme (AAE) consensus motif; other site 1286170000893 putative AMP binding site [chemical binding]; other site 1286170000894 putative active site [active] 1286170000895 putative CoA binding site [chemical binding]; other site 1286170000896 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1286170000897 YfaZ precursor; Region: YfaZ; pfam07437 1286170000898 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1286170000899 hypothetical protein; Provisional; Region: PRK03673 1286170000900 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1286170000901 putative MPT binding site; other site 1286170000902 Competence-damaged protein; Region: CinA; cl00666 1286170000903 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286170000904 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286170000905 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286170000906 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1286170000907 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1286170000908 putative active site pocket [active] 1286170000909 putative metal binding site [ion binding]; other site 1286170000910 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1286170000911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170000912 putative substrate translocation pore; other site 1286170000913 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1286170000914 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1286170000915 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286170000916 Cysteine-rich domain; Region: CCG; pfam02754 1286170000917 Cysteine-rich domain; Region: CCG; pfam02754 1286170000918 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1286170000919 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1286170000920 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1286170000921 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286170000922 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286170000923 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1286170000924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170000925 putative substrate translocation pore; other site 1286170000926 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1286170000927 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1286170000928 active site 1286170000929 catalytic site [active] 1286170000930 metal binding site [ion binding]; metal-binding site 1286170000931 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1286170000932 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286170000933 catalytic loop [active] 1286170000934 iron binding site [ion binding]; other site 1286170000935 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1286170000936 dimer interface [polypeptide binding]; other site 1286170000937 putative radical transfer pathway; other site 1286170000938 diiron center [ion binding]; other site 1286170000939 tyrosyl radical; other site 1286170000940 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1286170000941 ATP cone domain; Region: ATP-cone; pfam03477 1286170000942 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1286170000943 active site 1286170000944 dimer interface [polypeptide binding]; other site 1286170000945 catalytic residues [active] 1286170000946 effector binding site; other site 1286170000947 R2 peptide binding site; other site 1286170000948 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1286170000949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170000950 S-adenosylmethionine binding site [chemical binding]; other site 1286170000951 DNA gyrase subunit A; Validated; Region: PRK05560 1286170000952 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1286170000953 CAP-like domain; other site 1286170000954 active site 1286170000955 primary dimer interface [polypeptide binding]; other site 1286170000956 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286170000957 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286170000958 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286170000959 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286170000960 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286170000961 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286170000962 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1286170000963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170000964 dimer interface [polypeptide binding]; other site 1286170000965 phosphorylation site [posttranslational modification] 1286170000966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170000967 ATP binding site [chemical binding]; other site 1286170000968 Mg2+ binding site [ion binding]; other site 1286170000969 G-X-G motif; other site 1286170000970 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1286170000971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170000972 active site 1286170000973 phosphorylation site [posttranslational modification] 1286170000974 intermolecular recognition site; other site 1286170000975 dimerization interface [polypeptide binding]; other site 1286170000976 transcriptional regulator RcsB; Provisional; Region: PRK10840 1286170000977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170000978 active site 1286170000979 phosphorylation site [posttranslational modification] 1286170000980 intermolecular recognition site; other site 1286170000981 dimerization interface [polypeptide binding]; other site 1286170000982 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170000983 DNA binding residues [nucleotide binding] 1286170000984 dimerization interface [polypeptide binding]; other site 1286170000985 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1286170000986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170000987 ATP binding site [chemical binding]; other site 1286170000988 G-X-G motif; other site 1286170000989 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1286170000990 putative binding surface; other site 1286170000991 active site 1286170000992 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1286170000993 outer membrane porin protein C; Provisional; Region: PRK10554 1286170000994 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1286170000995 ApbE family; Region: ApbE; pfam02424 1286170000996 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1286170000997 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1286170000998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170000999 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1286170001000 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1286170001001 DNA binding site [nucleotide binding] 1286170001002 active site 1286170001003 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1286170001004 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1286170001005 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1286170001006 Walker A/P-loop; other site 1286170001007 ATP binding site [chemical binding]; other site 1286170001008 Q-loop/lid; other site 1286170001009 ABC transporter signature motif; other site 1286170001010 Walker B; other site 1286170001011 D-loop; other site 1286170001012 H-loop/switch region; other site 1286170001013 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1286170001014 MgtE intracellular N domain; Region: MgtE_N; smart00924 1286170001015 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1286170001016 Divalent cation transporter; Region: MgtE; cl00786 1286170001017 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1286170001018 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1286170001019 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1286170001020 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1286170001021 malate:quinone oxidoreductase; Validated; Region: PRK05257 1286170001022 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1286170001023 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1286170001024 secondary substrate binding site; other site 1286170001025 primary substrate binding site; other site 1286170001026 inhibition loop; other site 1286170001027 dimerization interface [polypeptide binding]; other site 1286170001028 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286170001029 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286170001030 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1286170001031 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1286170001032 Sulfatase; Region: Sulfatase; pfam00884 1286170001033 hypothetical protein; Provisional; Region: PRK13689 1286170001034 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1286170001035 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1286170001036 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286170001037 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1286170001038 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286170001039 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1286170001040 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1286170001041 dimer interface [polypeptide binding]; other site 1286170001042 ADP-ribose binding site [chemical binding]; other site 1286170001043 active site 1286170001044 nudix motif; other site 1286170001045 metal binding site [ion binding]; metal-binding site 1286170001046 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286170001047 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286170001048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170001049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170001050 dimerization interface [polypeptide binding]; other site 1286170001051 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170001052 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1286170001053 5S rRNA interface [nucleotide binding]; other site 1286170001054 CTC domain interface [polypeptide binding]; other site 1286170001055 L16 interface [polypeptide binding]; other site 1286170001056 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1286170001057 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286170001058 ATP binding site [chemical binding]; other site 1286170001059 putative Mg++ binding site [ion binding]; other site 1286170001060 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170001061 nucleotide binding region [chemical binding]; other site 1286170001062 ATP-binding site [chemical binding]; other site 1286170001063 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1286170001064 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286170001065 RNA binding surface [nucleotide binding]; other site 1286170001066 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1286170001067 active site 1286170001068 uracil binding [chemical binding]; other site 1286170001069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170001070 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1286170001071 putative substrate translocation pore; other site 1286170001072 hypothetical protein; Provisional; Region: PRK11835 1286170001073 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1286170001074 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170001075 Walker A/P-loop; other site 1286170001076 ATP binding site [chemical binding]; other site 1286170001077 Q-loop/lid; other site 1286170001078 ABC transporter signature motif; other site 1286170001079 Walker B; other site 1286170001080 D-loop; other site 1286170001081 H-loop/switch region; other site 1286170001082 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286170001083 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170001084 Walker A/P-loop; other site 1286170001085 ATP binding site [chemical binding]; other site 1286170001086 Q-loop/lid; other site 1286170001087 ABC transporter signature motif; other site 1286170001088 Walker B; other site 1286170001089 D-loop; other site 1286170001090 H-loop/switch region; other site 1286170001091 microcin C ABC transporter permease; Provisional; Region: PRK15021 1286170001092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170001093 dimer interface [polypeptide binding]; other site 1286170001094 conserved gate region; other site 1286170001095 ABC-ATPase subunit interface; other site 1286170001096 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1286170001097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170001098 dimer interface [polypeptide binding]; other site 1286170001099 conserved gate region; other site 1286170001100 putative PBP binding loops; other site 1286170001101 ABC-ATPase subunit interface; other site 1286170001102 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286170001103 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1286170001104 phage resistance protein; Provisional; Region: PRK10551 1286170001105 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1286170001106 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170001107 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1286170001108 NlpC/P60 family; Region: NLPC_P60; pfam00877 1286170001109 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1286170001110 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1286170001111 active site 1286170001112 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1286170001113 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1286170001114 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1286170001115 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1286170001116 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1286170001117 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1286170001118 mannonate dehydratase; Provisional; Region: PRK03906 1286170001119 mannonate dehydratase; Region: uxuA; TIGR00695 1286170001120 elongation factor P; Provisional; Region: PRK04542 1286170001121 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1286170001122 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1286170001123 RNA binding site [nucleotide binding]; other site 1286170001124 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1286170001125 RNA binding site [nucleotide binding]; other site 1286170001126 Flagellin N-methylase; Region: FliB; pfam03692 1286170001127 sugar efflux transporter B; Provisional; Region: PRK15011 1286170001128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170001129 putative substrate translocation pore; other site 1286170001130 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1286170001131 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286170001132 active site 1286170001133 phosphorylation site [posttranslational modification] 1286170001134 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1286170001135 dimerization domain swap beta strand [polypeptide binding]; other site 1286170001136 regulatory protein interface [polypeptide binding]; other site 1286170001137 active site 1286170001138 regulatory phosphorylation site [posttranslational modification]; other site 1286170001139 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1286170001140 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1286170001141 putative substrate binding site [chemical binding]; other site 1286170001142 putative ATP binding site [chemical binding]; other site 1286170001143 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1286170001144 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1286170001145 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1286170001146 active site 1286170001147 P-loop; other site 1286170001148 phosphorylation site [posttranslational modification] 1286170001149 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1286170001150 endonuclease IV; Provisional; Region: PRK01060 1286170001151 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1286170001152 AP (apurinic/apyrimidinic) site pocket; other site 1286170001153 DNA interaction; other site 1286170001154 Metal-binding active site; metal-binding site 1286170001155 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1286170001156 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1286170001157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170001158 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1286170001159 putative dimerization interface [polypeptide binding]; other site 1286170001160 lysine transporter; Provisional; Region: PRK10836 1286170001161 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 1286170001162 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170001163 N-terminal plug; other site 1286170001164 ligand-binding site [chemical binding]; other site 1286170001165 phage resistance protein; Provisional; Region: PRK10551 1286170001166 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1286170001167 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170001168 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1286170001169 S-formylglutathione hydrolase; Region: PLN02442 1286170001170 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1286170001171 GTP cyclohydrolase I; Provisional; Region: PLN03044 1286170001172 active site 1286170001173 Predicted membrane protein [Function unknown]; Region: COG2311 1286170001174 hypothetical protein; Provisional; Region: PRK10835 1286170001175 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1286170001176 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170001177 DNA binding site [nucleotide binding] 1286170001178 domain linker motif; other site 1286170001179 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1286170001180 dimerization interface (closed form) [polypeptide binding]; other site 1286170001181 ligand binding site [chemical binding]; other site 1286170001182 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1286170001183 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1286170001184 ligand binding site [chemical binding]; other site 1286170001185 calcium binding site [ion binding]; other site 1286170001186 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170001187 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1286170001188 Walker A/P-loop; other site 1286170001189 ATP binding site [chemical binding]; other site 1286170001190 Q-loop/lid; other site 1286170001191 ABC transporter signature motif; other site 1286170001192 Walker B; other site 1286170001193 D-loop; other site 1286170001194 H-loop/switch region; other site 1286170001195 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170001196 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170001197 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170001198 TM-ABC transporter signature motif; other site 1286170001199 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1286170001200 putative active site [active] 1286170001201 cytidine deaminase; Provisional; Region: PRK09027 1286170001202 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1286170001203 active site 1286170001204 catalytic motif [active] 1286170001205 Zn binding site [ion binding]; other site 1286170001206 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1286170001207 active site 1286170001208 catalytic motif [active] 1286170001209 Zn binding site [ion binding]; other site 1286170001210 hypothetical protein; Provisional; Region: PRK10711 1286170001211 hypothetical protein; Provisional; Region: PRK01821 1286170001212 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1286170001213 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1286170001214 FMN binding site [chemical binding]; other site 1286170001215 active site 1286170001216 catalytic residues [active] 1286170001217 substrate binding site [chemical binding]; other site 1286170001218 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1286170001219 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1286170001220 CAT RNA binding domain; Region: CAT_RBD; smart01061 1286170001221 PRD domain; Region: PRD; pfam00874 1286170001222 PRD domain; Region: PRD; pfam00874 1286170001223 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1286170001224 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170001225 active site turn [active] 1286170001226 phosphorylation site [posttranslational modification] 1286170001227 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286170001228 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1286170001229 HPr interaction site; other site 1286170001230 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1286170001231 active site 1286170001232 phosphorylation site [posttranslational modification] 1286170001233 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1286170001234 beta-galactosidase; Region: BGL; TIGR03356 1286170001235 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286170001236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170001237 S-adenosylmethionine binding site [chemical binding]; other site 1286170001238 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1286170001239 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286170001240 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286170001241 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1286170001242 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1286170001243 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1286170001244 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1286170001245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170001246 Coenzyme A binding pocket [chemical binding]; other site 1286170001247 D-lactate dehydrogenase; Provisional; Region: PRK11183 1286170001248 FAD binding domain; Region: FAD_binding_4; pfam01565 1286170001249 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1286170001250 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1286170001251 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1286170001252 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1286170001253 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1286170001254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170001255 conserved gate region; other site 1286170001256 ABC-ATPase subunit interface; other site 1286170001257 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1286170001258 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1286170001259 Walker A/P-loop; other site 1286170001260 ATP binding site [chemical binding]; other site 1286170001261 Q-loop/lid; other site 1286170001262 ABC transporter signature motif; other site 1286170001263 Walker B; other site 1286170001264 D-loop; other site 1286170001265 H-loop/switch region; other site 1286170001266 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1286170001267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170001268 putative PBP binding loops; other site 1286170001269 ABC-ATPase subunit interface; other site 1286170001270 hypothetical protein; Provisional; Region: PRK13681 1286170001271 transcriptional regulator MirA; Provisional; Region: PRK15043 1286170001272 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1286170001273 DNA binding residues [nucleotide binding] 1286170001274 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1286170001275 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1286170001276 GAF domain; Region: GAF; pfam01590 1286170001277 Histidine kinase; Region: His_kinase; pfam06580 1286170001278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170001279 ATP binding site [chemical binding]; other site 1286170001280 Mg2+ binding site [ion binding]; other site 1286170001281 G-X-G motif; other site 1286170001282 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1286170001283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170001284 active site 1286170001285 phosphorylation site [posttranslational modification] 1286170001286 intermolecular recognition site; other site 1286170001287 dimerization interface [polypeptide binding]; other site 1286170001288 LytTr DNA-binding domain; Region: LytTR; pfam04397 1286170001289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1286170001290 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1286170001291 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1286170001292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1286170001293 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1286170001294 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1286170001295 active site 1286170001296 HIGH motif; other site 1286170001297 KMSKS motif; other site 1286170001298 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1286170001299 tRNA binding surface [nucleotide binding]; other site 1286170001300 anticodon binding site; other site 1286170001301 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1286170001302 dimer interface [polypeptide binding]; other site 1286170001303 putative tRNA-binding site [nucleotide binding]; other site 1286170001304 antiporter inner membrane protein; Provisional; Region: PRK11670 1286170001305 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1286170001306 Walker A motif; other site 1286170001307 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1286170001308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170001309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170001310 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170001311 putative effector binding pocket; other site 1286170001312 dimerization interface [polypeptide binding]; other site 1286170001313 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1286170001314 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1286170001315 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286170001316 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286170001317 active site 1286170001318 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1286170001319 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170001320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170001321 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286170001322 dimerization interface [polypeptide binding]; other site 1286170001323 Universal stress protein family; Region: Usp; pfam00582 1286170001324 Ligand Binding Site [chemical binding]; other site 1286170001325 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1286170001326 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286170001327 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1286170001328 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286170001329 Transcriptional regulator; Region: Rrf2; cl17282 1286170001330 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1286170001331 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286170001332 SCP-2 sterol transfer family; Region: SCP2; cl01225 1286170001333 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1286170001334 substrate binding site [chemical binding]; other site 1286170001335 multimerization interface [polypeptide binding]; other site 1286170001336 ATP binding site [chemical binding]; other site 1286170001337 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1286170001338 dimer interface [polypeptide binding]; other site 1286170001339 substrate binding site [chemical binding]; other site 1286170001340 ATP binding site [chemical binding]; other site 1286170001341 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286170001342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170001343 DNA-binding site [nucleotide binding]; DNA binding site 1286170001344 UTRA domain; Region: UTRA; pfam07702 1286170001345 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1286170001346 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170001347 substrate binding site [chemical binding]; other site 1286170001348 ATP binding site [chemical binding]; other site 1286170001349 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1286170001350 nucleoside transporter; Region: 2A0110; TIGR00889 1286170001351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170001352 putative substrate translocation pore; other site 1286170001353 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1286170001354 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1286170001355 putative active site; other site 1286170001356 catalytic residue [active] 1286170001357 polyol permease family; Region: 2A0118; TIGR00897 1286170001358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170001359 putative substrate translocation pore; other site 1286170001360 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 1286170001361 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 1286170001362 N- and C-terminal domain interface [polypeptide binding]; other site 1286170001363 active site 1286170001364 MgATP binding site [chemical binding]; other site 1286170001365 catalytic site [active] 1286170001366 metal binding site [ion binding]; metal-binding site 1286170001367 carbohydrate binding site [chemical binding]; other site 1286170001368 putative homodimer interface [polypeptide binding]; other site 1286170001369 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1286170001370 classical (c) SDRs; Region: SDR_c; cd05233 1286170001371 NAD(P) binding site [chemical binding]; other site 1286170001372 active site 1286170001373 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170001374 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170001375 DNA binding site [nucleotide binding] 1286170001376 domain linker motif; other site 1286170001377 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1286170001378 dimerization interface [polypeptide binding]; other site 1286170001379 ligand binding site [chemical binding]; other site 1286170001380 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286170001381 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1286170001382 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286170001383 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1286170001384 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1286170001385 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1286170001386 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1286170001387 N- and C-terminal domain interface [polypeptide binding]; other site 1286170001388 D-xylulose kinase; Region: XylB; TIGR01312 1286170001389 active site 1286170001390 MgATP binding site [chemical binding]; other site 1286170001391 catalytic site [active] 1286170001392 metal binding site [ion binding]; metal-binding site 1286170001393 xylulose binding site [chemical binding]; other site 1286170001394 homodimer interface [polypeptide binding]; other site 1286170001395 polyol permease family; Region: 2A0118; TIGR00897 1286170001396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170001397 putative substrate translocation pore; other site 1286170001398 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1286170001399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170001400 motif II; other site 1286170001401 lipid kinase; Reviewed; Region: PRK13054 1286170001402 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1286170001403 putative protease; Provisional; Region: PRK15452 1286170001404 Peptidase family U32; Region: Peptidase_U32; pfam01136 1286170001405 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1286170001406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170001407 active site 1286170001408 phosphorylation site [posttranslational modification] 1286170001409 intermolecular recognition site; other site 1286170001410 dimerization interface [polypeptide binding]; other site 1286170001411 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170001412 DNA binding site [nucleotide binding] 1286170001413 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1286170001414 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286170001415 dimerization interface [polypeptide binding]; other site 1286170001416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170001417 dimer interface [polypeptide binding]; other site 1286170001418 phosphorylation site [posttranslational modification] 1286170001419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170001420 ATP binding site [chemical binding]; other site 1286170001421 Mg2+ binding site [ion binding]; other site 1286170001422 G-X-G motif; other site 1286170001423 putative transporter; Provisional; Region: PRK10504 1286170001424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170001425 putative substrate translocation pore; other site 1286170001426 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1286170001427 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1286170001428 Protein export membrane protein; Region: SecD_SecF; cl14618 1286170001429 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1286170001430 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170001431 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170001432 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1286170001433 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170001434 Amidinotransferase; Region: Amidinotransf; cl12043 1286170001435 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1286170001436 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170001437 substrate binding pocket [chemical binding]; other site 1286170001438 membrane-bound complex binding site; other site 1286170001439 hinge residues; other site 1286170001440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170001441 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170001442 dimer interface [polypeptide binding]; other site 1286170001443 conserved gate region; other site 1286170001444 putative PBP binding loops; other site 1286170001445 ABC-ATPase subunit interface; other site 1286170001446 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170001447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170001448 dimer interface [polypeptide binding]; other site 1286170001449 conserved gate region; other site 1286170001450 putative PBP binding loops; other site 1286170001451 ABC-ATPase subunit interface; other site 1286170001452 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286170001453 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1286170001454 AsnC family; Region: AsnC_trans_reg; pfam01037 1286170001455 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1286170001456 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1286170001457 active site 1286170001458 Zn binding site [ion binding]; other site 1286170001459 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1286170001460 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1286170001461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286170001462 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1286170001463 DNA binding residues [nucleotide binding] 1286170001464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286170001465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170001466 active site 1286170001467 phosphorylation site [posttranslational modification] 1286170001468 intermolecular recognition site; other site 1286170001469 dimerization interface [polypeptide binding]; other site 1286170001470 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1286170001471 DNA binding site [nucleotide binding] 1286170001472 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1286170001473 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1286170001474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1286170001475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170001476 dimer interface [polypeptide binding]; other site 1286170001477 phosphorylation site [posttranslational modification] 1286170001478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170001479 ATP binding site [chemical binding]; other site 1286170001480 Mg2+ binding site [ion binding]; other site 1286170001481 G-X-G motif; other site 1286170001482 putative chaperone; Provisional; Region: PRK11678 1286170001483 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1286170001484 nucleotide binding site [chemical binding]; other site 1286170001485 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1286170001486 SBD interface [polypeptide binding]; other site 1286170001487 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1286170001488 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1286170001489 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1286170001490 minor groove reading motif; other site 1286170001491 helix-hairpin-helix signature motif; other site 1286170001492 substrate binding pocket [chemical binding]; other site 1286170001493 active site 1286170001494 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1286170001495 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1286170001496 ATP-binding site [chemical binding]; other site 1286170001497 Sugar specificity; other site 1286170001498 Pyrimidine base specificity; other site 1286170001499 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1286170001500 trimer interface [polypeptide binding]; other site 1286170001501 active site 1286170001502 putative assembly protein; Provisional; Region: PRK10833 1286170001503 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1286170001504 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1286170001505 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1286170001506 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1286170001507 Transporter associated domain; Region: CorC_HlyC; smart01091 1286170001508 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1286170001509 active site 1286170001510 tetramer interface; other site 1286170001511 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1286170001512 active site 1286170001513 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 1286170001514 polysaccharide export protein Wza; Provisional; Region: PRK15078 1286170001515 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1286170001516 SLBB domain; Region: SLBB; pfam10531 1286170001517 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1286170001518 tyrosine kinase; Provisional; Region: PRK11519 1286170001519 Chain length determinant protein; Region: Wzz; pfam02706 1286170001520 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1286170001521 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1286170001522 Nucleotide binding site [chemical binding]; other site 1286170001523 DTAP/Switch II; other site 1286170001524 Switch I; other site 1286170001525 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 1286170001526 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1286170001527 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1286170001528 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286170001529 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1286170001530 active site 1286170001531 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1286170001532 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1286170001533 NAD binding site [chemical binding]; other site 1286170001534 substrate binding site [chemical binding]; other site 1286170001535 homodimer interface [polypeptide binding]; other site 1286170001536 active site 1286170001537 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1286170001538 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1286170001539 substrate binding site; other site 1286170001540 tetramer interface; other site 1286170001541 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1286170001542 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286170001543 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1286170001544 active site 1286170001545 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286170001546 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1286170001547 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1286170001548 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1286170001549 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1286170001550 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1286170001551 NADP binding site [chemical binding]; other site 1286170001552 active site 1286170001553 putative substrate binding site [chemical binding]; other site 1286170001554 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286170001555 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1286170001556 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1286170001557 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1286170001558 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1286170001559 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1286170001560 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1286170001561 Transposase; Region: HTH_Tnp_1; pfam01527 1286170001562 HTH-like domain; Region: HTH_21; pfam13276 1286170001563 Integrase core domain; Region: rve; pfam00665 1286170001564 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1286170001565 DNA-binding interface [nucleotide binding]; DNA binding site 1286170001566 HTH-like domain; Region: HTH_21; pfam13276 1286170001567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1286170001568 Integrase core domain; Region: rve; pfam00665 1286170001569 Integrase core domain; Region: rve_3; pfam13683 1286170001570 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286170001571 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1286170001572 putative NAD(P) binding site [chemical binding]; other site 1286170001573 active site 1286170001574 putative substrate binding site [chemical binding]; other site 1286170001575 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1286170001576 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1286170001577 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1286170001578 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1286170001579 Walker A/P-loop; other site 1286170001580 ATP binding site [chemical binding]; other site 1286170001581 Q-loop/lid; other site 1286170001582 ABC transporter signature motif; other site 1286170001583 Walker B; other site 1286170001584 D-loop; other site 1286170001585 H-loop/switch region; other site 1286170001586 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1286170001587 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1286170001588 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1286170001589 Ligand binding site; other site 1286170001590 metal-binding site 1286170001591 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1286170001592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286170001593 UDP-galactopyranose mutase; Region: GLF; pfam03275 1286170001594 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1286170001595 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286170001596 active site 1286170001597 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1286170001598 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286170001599 putative ADP-binding pocket [chemical binding]; other site 1286170001600 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286170001601 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286170001602 active site 1286170001603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1286170001604 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1286170001605 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1286170001606 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1286170001607 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1286170001608 metal binding site [ion binding]; metal-binding site 1286170001609 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1286170001610 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1286170001611 substrate binding site [chemical binding]; other site 1286170001612 glutamase interaction surface [polypeptide binding]; other site 1286170001613 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1286170001614 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1286170001615 catalytic residues [active] 1286170001616 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1286170001617 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1286170001618 putative active site [active] 1286170001619 oxyanion strand; other site 1286170001620 catalytic triad [active] 1286170001621 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1286170001622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170001623 active site 1286170001624 motif I; other site 1286170001625 motif II; other site 1286170001626 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1286170001627 putative active site pocket [active] 1286170001628 4-fold oligomerization interface [polypeptide binding]; other site 1286170001629 metal binding residues [ion binding]; metal-binding site 1286170001630 3-fold/trimer interface [polypeptide binding]; other site 1286170001631 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1286170001632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170001633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170001634 homodimer interface [polypeptide binding]; other site 1286170001635 catalytic residue [active] 1286170001636 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1286170001637 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1286170001638 NAD binding site [chemical binding]; other site 1286170001639 dimerization interface [polypeptide binding]; other site 1286170001640 product binding site; other site 1286170001641 substrate binding site [chemical binding]; other site 1286170001642 zinc binding site [ion binding]; other site 1286170001643 catalytic residues [active] 1286170001644 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1286170001645 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1286170001646 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1286170001647 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286170001648 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1286170001649 putative NAD(P) binding site [chemical binding]; other site 1286170001650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170001651 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1286170001652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170001653 dimerization interface [polypeptide binding]; other site 1286170001654 amino acid transporter; Region: 2A0306; TIGR00909 1286170001655 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286170001656 dimerization interface [polypeptide binding]; other site 1286170001657 putative DNA binding site [nucleotide binding]; other site 1286170001658 putative Zn2+ binding site [ion binding]; other site 1286170001659 elongation factor G; Reviewed; Region: PRK00007 1286170001660 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1286170001661 G1 box; other site 1286170001662 putative GEF interaction site [polypeptide binding]; other site 1286170001663 GTP/Mg2+ binding site [chemical binding]; other site 1286170001664 Switch I region; other site 1286170001665 G2 box; other site 1286170001666 G3 box; other site 1286170001667 Switch II region; other site 1286170001668 G4 box; other site 1286170001669 G5 box; other site 1286170001670 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1286170001671 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1286170001672 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1286170001673 exonuclease I; Provisional; Region: sbcB; PRK11779 1286170001674 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1286170001675 active site 1286170001676 catalytic site [active] 1286170001677 substrate binding site [chemical binding]; other site 1286170001678 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1286170001679 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1286170001680 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286170001681 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1286170001682 DNA gyrase inhibitor; Provisional; Region: PRK10016 1286170001683 Predicted membrane protein [Function unknown]; Region: COG1289 1286170001684 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1286170001685 hypothetical protein; Provisional; Region: PRK05423 1286170001686 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1286170001687 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1286170001688 putative dimer interface [polypeptide binding]; other site 1286170001689 active site pocket [active] 1286170001690 putative cataytic base [active] 1286170001691 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1286170001692 NAD binding site [chemical binding]; other site 1286170001693 HPP family; Region: HPP; pfam04982 1286170001694 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1286170001695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170001696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170001697 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170001698 putative effector binding pocket; other site 1286170001699 dimerization interface [polypeptide binding]; other site 1286170001700 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1286170001701 shikimate transporter; Provisional; Region: PRK09952 1286170001702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170001703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170001704 putative substrate translocation pore; other site 1286170001705 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1286170001706 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170001707 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170001708 metal binding site [ion binding]; metal-binding site 1286170001709 active site 1286170001710 I-site; other site 1286170001711 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170001712 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 1286170001713 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1286170001714 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286170001715 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1286170001716 Metal-binding active site; metal-binding site 1286170001717 Protein of unknown function (DUF993); Region: DUF993; pfam06187 1286170001718 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286170001719 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286170001720 active site 1286170001721 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1286170001722 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286170001723 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1286170001724 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 1286170001725 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1286170001726 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1286170001727 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1286170001728 Ligand binding site [chemical binding]; other site 1286170001729 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1286170001730 choline dehydrogenase; Validated; Region: PRK02106 1286170001731 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1286170001732 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286170001733 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 1286170001734 NAD(P) binding site [chemical binding]; other site 1286170001735 catalytic residues [active] 1286170001736 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1286170001737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170001738 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1286170001739 Coenzyme A transferase; Region: CoA_trans; smart00882 1286170001740 Coenzyme A transferase; Region: CoA_trans; cl17247 1286170001741 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170001742 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170001743 active site 1286170001744 catalytic tetrad [active] 1286170001745 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286170001746 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286170001747 NAD(P) binding site [chemical binding]; other site 1286170001748 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170001749 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170001750 TM-ABC transporter signature motif; other site 1286170001751 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286170001752 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170001753 Walker A/P-loop; other site 1286170001754 ATP binding site [chemical binding]; other site 1286170001755 Q-loop/lid; other site 1286170001756 ABC transporter signature motif; other site 1286170001757 Walker B; other site 1286170001758 D-loop; other site 1286170001759 H-loop/switch region; other site 1286170001760 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170001761 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170001762 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170001763 TM-ABC transporter signature motif; other site 1286170001764 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286170001765 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1286170001766 ligand binding site [chemical binding]; other site 1286170001767 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1286170001768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170001769 NAD(P) binding site [chemical binding]; other site 1286170001770 active site 1286170001771 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1286170001772 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170001773 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170001774 active site 1286170001775 catalytic tetrad [active] 1286170001776 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1286170001777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170001778 putative substrate translocation pore; other site 1286170001779 potential frameshift: common BLAST hit: gi|226944187|ref|YP_002799260.1| multidrug/chloramphenicol efflux transporter, major facilitator 1286170001780 Domain of unknown function (DUF336); Region: DUF336; cl01249 1286170001781 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286170001782 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286170001783 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286170001784 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1286170001785 MATE family multidrug exporter; Provisional; Region: PRK10189 1286170001786 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1286170001787 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1286170001788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170001789 active site 1286170001790 motif I; other site 1286170001791 motif II; other site 1286170001792 AMP nucleosidase; Provisional; Region: PRK08292 1286170001793 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1286170001794 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1286170001795 Polymyxin resistance protein PmrD; Region: PmrD; cl12732 1286170001796 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1286170001797 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170001798 N-terminal plug; other site 1286170001799 ligand-binding site [chemical binding]; other site 1286170001800 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1286170001801 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1286170001802 acyl-activating enzyme (AAE) consensus motif; other site 1286170001803 active site 1286170001804 AMP binding site [chemical binding]; other site 1286170001805 substrate binding site [chemical binding]; other site 1286170001806 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1286170001807 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 1286170001808 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286170001809 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1286170001810 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1286170001811 active site 1286170001812 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1286170001813 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1286170001814 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1286170001815 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1286170001816 KR domain; Region: KR; pfam08659 1286170001817 NADP binding site [chemical binding]; other site 1286170001818 active site 1286170001819 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286170001820 Condensation domain; Region: Condensation; pfam00668 1286170001821 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286170001822 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1286170001823 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1286170001824 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286170001825 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1286170001826 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1286170001827 Condensation domain; Region: Condensation; pfam00668 1286170001828 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286170001829 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1286170001830 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1286170001831 acyl-activating enzyme (AAE) consensus motif; other site 1286170001832 AMP binding site [chemical binding]; other site 1286170001833 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1286170001834 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1286170001835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286170001836 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286170001837 Condensation domain; Region: Condensation; pfam00668 1286170001838 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286170001839 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1286170001840 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286170001841 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170001842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170001843 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286170001844 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286170001845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170001846 Walker A/P-loop; other site 1286170001847 ATP binding site [chemical binding]; other site 1286170001848 Q-loop/lid; other site 1286170001849 ABC transporter signature motif; other site 1286170001850 Walker B; other site 1286170001851 D-loop; other site 1286170001852 H-loop/switch region; other site 1286170001853 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286170001854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170001855 Walker A/P-loop; other site 1286170001856 ATP binding site [chemical binding]; other site 1286170001857 Q-loop/lid; other site 1286170001858 ABC transporter signature motif; other site 1286170001859 Walker B; other site 1286170001860 D-loop; other site 1286170001861 H-loop/switch region; other site 1286170001862 muropeptide transporter; Validated; Region: ampG; cl17669 1286170001863 salicylate synthase Irp9; Reviewed; Region: PRK06772 1286170001864 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1286170001865 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1286170001866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170001867 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1286170001868 putative dimerization interface [polypeptide binding]; other site 1286170001869 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1286170001870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170001871 dimerization interface [polypeptide binding]; other site 1286170001872 L,D-transpeptidase; Provisional; Region: PRK10190 1286170001873 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286170001874 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1286170001875 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286170001876 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 1286170001877 ligand binding site [chemical binding]; other site 1286170001878 dimerization interface [polypeptide binding]; other site 1286170001879 zinc binding site [ion binding]; other site 1286170001880 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286170001881 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170001882 Walker A/P-loop; other site 1286170001883 ATP binding site [chemical binding]; other site 1286170001884 Q-loop/lid; other site 1286170001885 ABC transporter signature motif; other site 1286170001886 Walker B; other site 1286170001887 D-loop; other site 1286170001888 H-loop/switch region; other site 1286170001889 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170001890 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170001891 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170001892 TM-ABC transporter signature motif; other site 1286170001893 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 1286170001894 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170001895 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170001896 putative active site [active] 1286170001897 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170001898 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1286170001899 substrate binding site [chemical binding]; other site 1286170001900 dimer interface [polypeptide binding]; other site 1286170001901 ATP binding site [chemical binding]; other site 1286170001902 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1286170001903 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1286170001904 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1286170001905 eyelet of channel; other site 1286170001906 trimer interface [polypeptide binding]; other site 1286170001907 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1286170001908 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286170001909 Zn2+ binding site [ion binding]; other site 1286170001910 Mg2+ binding site [ion binding]; other site 1286170001911 DNA cytosine methylase; Provisional; Region: PRK10458 1286170001912 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1286170001913 cofactor binding site; other site 1286170001914 DNA binding site [nucleotide binding] 1286170001915 substrate interaction site [chemical binding]; other site 1286170001916 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1286170001917 additional DNA contacts [nucleotide binding]; other site 1286170001918 mismatch recognition site; other site 1286170001919 active site 1286170001920 zinc binding site [ion binding]; other site 1286170001921 DNA intercalation site [nucleotide binding]; other site 1286170001922 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1286170001923 EamA-like transporter family; Region: EamA; pfam00892 1286170001924 hypothetical protein; Provisional; Region: PRK10062 1286170001925 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 1286170001926 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1286170001927 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170001928 metal binding site [ion binding]; metal-binding site 1286170001929 active site 1286170001930 I-site; other site 1286170001931 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1286170001932 hypothetical protein; Provisional; Region: PRK10708 1286170001933 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1286170001934 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170001935 DNA binding residues [nucleotide binding] 1286170001936 dimerization interface [polypeptide binding]; other site 1286170001937 lipoprotein; Provisional; Region: PRK10397 1286170001938 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1286170001939 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1286170001940 active site 1286170001941 Na/Ca binding site [ion binding]; other site 1286170001942 catalytic site [active] 1286170001943 cystine transporter subunit; Provisional; Region: PRK11260 1286170001944 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170001945 substrate binding pocket [chemical binding]; other site 1286170001946 membrane-bound complex binding site; other site 1286170001947 hinge residues; other site 1286170001948 D-cysteine desulfhydrase; Validated; Region: PRK03910 1286170001949 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1286170001950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170001951 catalytic residue [active] 1286170001952 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170001953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170001954 dimer interface [polypeptide binding]; other site 1286170001955 conserved gate region; other site 1286170001956 putative PBP binding loops; other site 1286170001957 ABC-ATPase subunit interface; other site 1286170001958 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1286170001959 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286170001960 Walker A/P-loop; other site 1286170001961 ATP binding site [chemical binding]; other site 1286170001962 Q-loop/lid; other site 1286170001963 ABC transporter signature motif; other site 1286170001964 Walker B; other site 1286170001965 D-loop; other site 1286170001966 H-loop/switch region; other site 1286170001967 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1286170001968 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1286170001969 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1286170001970 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1286170001971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170001972 DNA binding residues [nucleotide binding] 1286170001973 dimerization interface [polypeptide binding]; other site 1286170001974 hypothetical protein; Provisional; Region: PRK10613 1286170001975 response regulator; Provisional; Region: PRK09483 1286170001976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170001977 active site 1286170001978 phosphorylation site [posttranslational modification] 1286170001979 intermolecular recognition site; other site 1286170001980 dimerization interface [polypeptide binding]; other site 1286170001981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170001982 DNA binding residues [nucleotide binding] 1286170001983 dimerization interface [polypeptide binding]; other site 1286170001984 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1286170001985 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1286170001986 GIY-YIG motif/motif A; other site 1286170001987 active site 1286170001988 catalytic site [active] 1286170001989 putative DNA binding site [nucleotide binding]; other site 1286170001990 metal binding site [ion binding]; metal-binding site 1286170001991 UvrB/uvrC motif; Region: UVR; pfam02151 1286170001992 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1286170001993 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1286170001994 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1286170001995 active site 1286170001996 metal binding site [ion binding]; metal-binding site 1286170001997 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1286170001998 DMAP1-binding Domain; Region: DMAP_binding; pfam06464 1286170001999 hypothetical protein; Provisional; Region: PRK10396 1286170002000 yecA family protein; Region: ygfB_yecA; TIGR02292 1286170002001 SEC-C motif; Region: SEC-C; pfam02810 1286170002002 tyrosine transporter TyrP; Provisional; Region: PRK15132 1286170002003 aromatic amino acid transport protein; Region: araaP; TIGR00837 1286170002004 probable metal-binding protein; Region: matur_matur; TIGR03853 1286170002005 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1286170002006 Ferritin-like domain; Region: Ferritin; pfam00210 1286170002007 ferroxidase diiron center [ion binding]; other site 1286170002008 hypothetical protein; Provisional; Region: PRK09273 1286170002009 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 1286170002010 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 1286170002011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170002012 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170002013 putative substrate translocation pore; other site 1286170002014 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1286170002015 MFS/sugar transport protein; Region: MFS_2; pfam13347 1286170002016 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1286170002017 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1286170002018 Ferritin-like domain; Region: Ferritin; pfam00210 1286170002019 ferroxidase diiron center [ion binding]; other site 1286170002020 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1286170002021 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1286170002022 ligand binding site [chemical binding]; other site 1286170002023 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1286170002024 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170002025 Walker A/P-loop; other site 1286170002026 ATP binding site [chemical binding]; other site 1286170002027 Q-loop/lid; other site 1286170002028 ABC transporter signature motif; other site 1286170002029 Walker B; other site 1286170002030 D-loop; other site 1286170002031 H-loop/switch region; other site 1286170002032 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170002033 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170002034 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170002035 TM-ABC transporter signature motif; other site 1286170002036 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1286170002037 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1286170002038 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1286170002039 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1286170002040 active site 1286170002041 homotetramer interface [polypeptide binding]; other site 1286170002042 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286170002043 Ligand Binding Site [chemical binding]; other site 1286170002044 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1286170002045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170002046 putative substrate translocation pore; other site 1286170002047 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1286170002048 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1286170002049 arginyl-tRNA synthetase; Region: argS; TIGR00456 1286170002050 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1286170002051 active site 1286170002052 HIGH motif; other site 1286170002053 KMSK motif region; other site 1286170002054 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1286170002055 tRNA binding surface [nucleotide binding]; other site 1286170002056 anticodon binding site; other site 1286170002057 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1286170002058 putative metal binding site [ion binding]; other site 1286170002059 copper homeostasis protein CutC; Provisional; Region: PRK11572 1286170002060 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286170002061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170002062 S-adenosylmethionine binding site [chemical binding]; other site 1286170002063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170002064 S-adenosylmethionine binding site [chemical binding]; other site 1286170002065 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1286170002066 hypothetical protein; Provisional; Region: PRK10302 1286170002067 Isochorismatase family; Region: Isochorismatase; pfam00857 1286170002068 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1286170002069 catalytic triad [active] 1286170002070 conserved cis-peptide bond; other site 1286170002071 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1286170002072 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1286170002073 dimer interface [polypeptide binding]; other site 1286170002074 anticodon binding site; other site 1286170002075 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1286170002076 homodimer interface [polypeptide binding]; other site 1286170002077 motif 1; other site 1286170002078 active site 1286170002079 motif 2; other site 1286170002080 GAD domain; Region: GAD; pfam02938 1286170002081 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1286170002082 active site 1286170002083 motif 3; other site 1286170002084 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1286170002085 nudix motif; other site 1286170002086 hypothetical protein; Validated; Region: PRK00110 1286170002087 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1286170002088 active site 1286170002089 putative DNA-binding cleft [nucleotide binding]; other site 1286170002090 dimer interface [polypeptide binding]; other site 1286170002091 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1286170002092 RuvA N terminal domain; Region: RuvA_N; pfam01330 1286170002093 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1286170002094 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1286170002095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170002096 Walker A motif; other site 1286170002097 ATP binding site [chemical binding]; other site 1286170002098 Walker B motif; other site 1286170002099 arginine finger; other site 1286170002100 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1286170002101 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1286170002102 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170002103 ABC-ATPase subunit interface; other site 1286170002104 dimer interface [polypeptide binding]; other site 1286170002105 putative PBP binding regions; other site 1286170002106 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1286170002107 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1286170002108 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1286170002109 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1286170002110 metal binding site [ion binding]; metal-binding site 1286170002111 putative peptidase; Provisional; Region: PRK11649 1286170002112 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1286170002113 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286170002114 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286170002115 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1286170002116 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1286170002117 putative acyl-acceptor binding pocket; other site 1286170002118 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1286170002119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170002120 active site 1286170002121 phosphorylation site [posttranslational modification] 1286170002122 intermolecular recognition site; other site 1286170002123 dimerization interface [polypeptide binding]; other site 1286170002124 malate dehydrogenase; Provisional; Region: PRK13529 1286170002125 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1286170002126 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1286170002127 NAD(P) binding site [chemical binding]; other site 1286170002128 Predicted permeases [General function prediction only]; Region: COG0679 1286170002129 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1286170002130 pyruvate kinase; Provisional; Region: PRK05826 1286170002131 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1286170002132 domain interfaces; other site 1286170002133 active site 1286170002134 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1286170002135 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170002136 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170002137 putative active site [active] 1286170002138 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1286170002139 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1286170002140 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1286170002141 phosphogluconate dehydratase; Validated; Region: PRK09054 1286170002142 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1286170002143 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1286170002144 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1286170002145 active site 1286170002146 intersubunit interface [polypeptide binding]; other site 1286170002147 catalytic residue [active] 1286170002148 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1286170002149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170002150 ATP-grasp domain; Region: ATP-grasp; pfam02222 1286170002151 YebG protein; Region: YebG; pfam07130 1286170002152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1286170002153 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1286170002154 putative metal binding site [ion binding]; other site 1286170002155 protease 2; Provisional; Region: PRK10115 1286170002156 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286170002157 exodeoxyribonuclease X; Provisional; Region: PRK07983 1286170002158 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1286170002159 active site 1286170002160 catalytic site [active] 1286170002161 substrate binding site [chemical binding]; other site 1286170002162 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1286170002163 CopC domain; Region: CopC; cl01012 1286170002164 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1286170002165 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1286170002166 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1286170002167 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 1286170002168 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286170002169 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1286170002170 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1286170002171 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1286170002172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170002173 S-adenosylmethionine binding site [chemical binding]; other site 1286170002174 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1286170002175 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1286170002176 mce related protein; Region: MCE; pfam02470 1286170002177 mce related protein; Region: MCE; pfam02470 1286170002178 mce related protein; Region: MCE; pfam02470 1286170002179 mce related protein; Region: MCE; pfam02470 1286170002180 mce related protein; Region: MCE; pfam02470 1286170002181 mce related protein; Region: MCE; pfam02470 1286170002182 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 1286170002183 Paraquat-inducible protein A; Region: PqiA; pfam04403 1286170002184 Paraquat-inducible protein A; Region: PqiA; pfam04403 1286170002185 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1286170002186 GAF domain; Region: GAF_2; pfam13185 1286170002187 ProP expression regulator; Provisional; Region: PRK04950 1286170002188 ProQ/FINO family; Region: ProQ; pfam04352 1286170002189 carboxy-terminal protease; Provisional; Region: PRK11186 1286170002190 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1286170002191 protein binding site [polypeptide binding]; other site 1286170002192 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1286170002193 Catalytic dyad [active] 1286170002194 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1286170002195 heat shock protein HtpX; Provisional; Region: PRK05457 1286170002196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170002197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170002198 putative substrate translocation pore; other site 1286170002199 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1286170002200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286170002201 dimerization interface [polypeptide binding]; other site 1286170002202 putative Zn2+ binding site [ion binding]; other site 1286170002203 putative DNA binding site [nucleotide binding]; other site 1286170002204 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286170002205 YobH-like protein; Region: YobH; pfam13996 1286170002206 PhoPQ regulatory protein; Provisional; Region: PRK10299 1286170002207 YebO-like protein; Region: YebO; pfam13974 1286170002208 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1286170002209 Switch I region; other site 1286170002210 G3 box; other site 1286170002211 Switch II region; other site 1286170002212 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286170002213 DNA-binding site [nucleotide binding]; DNA binding site 1286170002214 RNA-binding motif; other site 1286170002215 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1286170002216 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286170002217 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286170002218 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1286170002219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170002220 S-adenosylmethionine binding site [chemical binding]; other site 1286170002221 hypothetical protein; Provisional; Region: PRK11469 1286170002222 Domain of unknown function DUF; Region: DUF204; pfam02659 1286170002223 Domain of unknown function DUF; Region: DUF204; pfam02659 1286170002224 hypothetical protein; Provisional; Region: PRK02913 1286170002225 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1286170002226 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1286170002227 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1286170002228 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1286170002229 active pocket/dimerization site; other site 1286170002230 active site 1286170002231 phosphorylation site [posttranslational modification] 1286170002232 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1286170002233 active site 1286170002234 phosphorylation site [posttranslational modification] 1286170002235 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1286170002236 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1286170002237 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1286170002238 Transporter associated domain; Region: CorC_HlyC; smart01091 1286170002239 phage resistance protein; Provisional; Region: PRK10551 1286170002240 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1286170002241 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170002242 L-serine deaminase; Provisional; Region: PRK15023 1286170002243 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1286170002244 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1286170002245 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1286170002246 putative active site [active] 1286170002247 putative CoA binding site [chemical binding]; other site 1286170002248 nudix motif; other site 1286170002249 metal binding site [ion binding]; metal-binding site 1286170002250 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1286170002251 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1286170002252 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1286170002253 hypothetical protein; Provisional; Region: PRK05114 1286170002254 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1286170002255 homotrimer interaction site [polypeptide binding]; other site 1286170002256 putative active site [active] 1286170002257 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1286170002258 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1286170002259 DEAD_2; Region: DEAD_2; pfam06733 1286170002260 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1286170002261 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1286170002262 Glycoprotease family; Region: Peptidase_M22; pfam00814 1286170002263 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1286170002264 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1286170002265 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286170002266 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1286170002267 acyl-activating enzyme (AAE) consensus motif; other site 1286170002268 putative AMP binding site [chemical binding]; other site 1286170002269 putative active site [active] 1286170002270 putative CoA binding site [chemical binding]; other site 1286170002271 ribonuclease D; Provisional; Region: PRK10829 1286170002272 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1286170002273 catalytic site [active] 1286170002274 putative active site [active] 1286170002275 putative substrate binding site [chemical binding]; other site 1286170002276 HRDC domain; Region: HRDC; cl02578 1286170002277 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1286170002278 cell division inhibitor MinD; Provisional; Region: PRK10818 1286170002279 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1286170002280 Switch I; other site 1286170002281 Switch II; other site 1286170002282 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1286170002283 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1286170002284 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1286170002285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1286170002286 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1286170002287 hypothetical protein; Provisional; Region: PRK10691 1286170002288 hypothetical protein; Provisional; Region: PRK05170 1286170002289 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1286170002290 disulfide bond formation protein B; Provisional; Region: PRK01749 1286170002291 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1286170002292 fatty acid metabolism regulator; Provisional; Region: PRK04984 1286170002293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170002294 DNA-binding site [nucleotide binding]; DNA binding site 1286170002295 FadR C-terminal domain; Region: FadR_C; pfam07840 1286170002296 SpoVR family protein; Provisional; Region: PRK11767 1286170002297 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1286170002298 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1286170002299 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170002300 alanine racemase; Reviewed; Region: dadX; PRK03646 1286170002301 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1286170002302 active site 1286170002303 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286170002304 substrate binding site [chemical binding]; other site 1286170002305 catalytic residues [active] 1286170002306 dimer interface [polypeptide binding]; other site 1286170002307 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286170002308 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1286170002309 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1286170002310 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286170002311 Protein export membrane protein; Region: SecD_SecF; cl14618 1286170002312 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286170002313 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170002314 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286170002315 Ligand Binding Site [chemical binding]; other site 1286170002316 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1286170002317 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1286170002318 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286170002319 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1286170002320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170002321 motif II; other site 1286170002322 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1286170002323 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1286170002324 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1286170002325 TrkA-C domain; Region: TrkA_C; pfam02080 1286170002326 Transporter associated domain; Region: CorC_HlyC; smart01091 1286170002327 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1286170002328 dimer interface [polypeptide binding]; other site 1286170002329 catalytic triad [active] 1286170002330 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1286170002331 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286170002332 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286170002333 catalytic residue [active] 1286170002334 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1286170002335 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170002336 N-terminal plug; other site 1286170002337 ligand-binding site [chemical binding]; other site 1286170002338 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1286170002339 MOSC domain; Region: MOSC; pfam03473 1286170002340 3-alpha domain; Region: 3-alpha; pfam03475 1286170002341 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1286170002342 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170002343 N-terminal plug; other site 1286170002344 ligand-binding site [chemical binding]; other site 1286170002345 molybdenum transport protein ModD; Provisional; Region: PRK06096 1286170002346 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 1286170002347 dimerization interface [polypeptide binding]; other site 1286170002348 active site 1286170002349 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286170002350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170002351 S-adenosylmethionine binding site [chemical binding]; other site 1286170002352 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1286170002353 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286170002354 Walker A/P-loop; other site 1286170002355 ATP binding site [chemical binding]; other site 1286170002356 Q-loop/lid; other site 1286170002357 ABC transporter signature motif; other site 1286170002358 Walker B; other site 1286170002359 D-loop; other site 1286170002360 H-loop/switch region; other site 1286170002361 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286170002362 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170002363 ABC-ATPase subunit interface; other site 1286170002364 dimer interface [polypeptide binding]; other site 1286170002365 putative PBP binding regions; other site 1286170002366 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1286170002367 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1286170002368 intersubunit interface [polypeptide binding]; other site 1286170002369 Trehalase; Region: Trehalase; cl17346 1286170002370 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1286170002371 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1286170002372 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286170002373 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1286170002374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1286170002375 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1286170002376 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1286170002377 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1286170002378 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1286170002379 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1286170002380 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 1286170002381 Helix-turn-helix domain; Region: HTH_18; pfam12833 1286170002382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170002383 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1286170002384 putative substrate translocation pore; other site 1286170002385 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286170002386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170002387 Walker A/P-loop; other site 1286170002388 ATP binding site [chemical binding]; other site 1286170002389 Q-loop/lid; other site 1286170002390 ABC transporter signature motif; other site 1286170002391 Walker B; other site 1286170002392 D-loop; other site 1286170002393 H-loop/switch region; other site 1286170002394 TOBE domain; Region: TOBE_2; pfam08402 1286170002395 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170002396 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1286170002397 substrate binding site [chemical binding]; other site 1286170002398 ATP binding site [chemical binding]; other site 1286170002399 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286170002400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170002401 dimer interface [polypeptide binding]; other site 1286170002402 conserved gate region; other site 1286170002403 putative PBP binding loops; other site 1286170002404 ABC-ATPase subunit interface; other site 1286170002405 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286170002406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170002407 dimer interface [polypeptide binding]; other site 1286170002408 conserved gate region; other site 1286170002409 putative PBP binding loops; other site 1286170002410 ABC-ATPase subunit interface; other site 1286170002411 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286170002412 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286170002413 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286170002414 non-specific DNA interactions [nucleotide binding]; other site 1286170002415 DNA binding site [nucleotide binding] 1286170002416 sequence specific DNA binding site [nucleotide binding]; other site 1286170002417 putative cAMP binding site [chemical binding]; other site 1286170002418 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286170002419 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286170002420 nucleotide binding site [chemical binding]; other site 1286170002421 riboflavin synthase subunit beta; Provisional; Region: PRK12419 1286170002422 active site 1286170002423 homopentamer interface [polypeptide binding]; other site 1286170002424 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 1286170002425 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1286170002426 putative di-iron ligands [ion binding]; other site 1286170002427 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1286170002428 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1286170002429 active site 1286170002430 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1286170002431 non-prolyl cis peptide bond; other site 1286170002432 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1286170002433 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1286170002434 dimer interface [polypeptide binding]; other site 1286170002435 conserved gate region; other site 1286170002436 ABC-ATPase subunit interface; other site 1286170002437 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1286170002438 conserved gate region; other site 1286170002439 ABC-ATPase subunit interface; other site 1286170002440 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1286170002441 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1286170002442 Walker A/P-loop; other site 1286170002443 ATP binding site [chemical binding]; other site 1286170002444 Q-loop/lid; other site 1286170002445 ABC transporter signature motif; other site 1286170002446 Walker B; other site 1286170002447 D-loop; other site 1286170002448 H-loop/switch region; other site 1286170002449 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1286170002450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170002451 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1286170002452 putative substrate binding pocket [chemical binding]; other site 1286170002453 putative dimerization interface [polypeptide binding]; other site 1286170002454 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1286170002455 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1286170002456 tetramer interface [polypeptide binding]; other site 1286170002457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170002458 catalytic residue [active] 1286170002459 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1286170002460 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1286170002461 propionate/acetate kinase; Provisional; Region: PRK12379 1286170002462 Acetokinase family; Region: Acetate_kinase; cl17229 1286170002463 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1286170002464 Pyruvate formate lyase 1; Region: PFL1; cd01678 1286170002465 coenzyme A binding site [chemical binding]; other site 1286170002466 active site 1286170002467 catalytic residues [active] 1286170002468 glycine loop; other site 1286170002469 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286170002470 homotrimer interaction site [polypeptide binding]; other site 1286170002471 putative active site [active] 1286170002472 L-serine dehydratase TdcG; Provisional; Region: PRK15040 1286170002473 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1286170002474 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1286170002475 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1286170002476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170002477 putative substrate translocation pore; other site 1286170002478 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1286170002479 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1286170002480 active site 1286170002481 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1286170002482 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1286170002483 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1286170002484 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1286170002485 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1286170002486 conserved cys residue [active] 1286170002487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170002488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170002489 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286170002490 FAD binding domain; Region: FAD_binding_4; pfam01565 1286170002491 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286170002492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170002493 dimer interface [polypeptide binding]; other site 1286170002494 conserved gate region; other site 1286170002495 putative PBP binding loops; other site 1286170002496 ABC-ATPase subunit interface; other site 1286170002497 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286170002498 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286170002499 Walker A/P-loop; other site 1286170002500 ATP binding site [chemical binding]; other site 1286170002501 Q-loop/lid; other site 1286170002502 ABC transporter signature motif; other site 1286170002503 Walker B; other site 1286170002504 D-loop; other site 1286170002505 H-loop/switch region; other site 1286170002506 NMT1/THI5 like; Region: NMT1; pfam09084 1286170002507 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1286170002508 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286170002509 homotrimer interaction site [polypeptide binding]; other site 1286170002510 putative active site [active] 1286170002511 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1286170002512 active site 1286170002513 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1286170002514 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1286170002515 FMN-binding pocket [chemical binding]; other site 1286170002516 flavin binding motif; other site 1286170002517 phosphate binding motif [ion binding]; other site 1286170002518 beta-alpha-beta structure motif; other site 1286170002519 NAD binding pocket [chemical binding]; other site 1286170002520 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286170002521 catalytic loop [active] 1286170002522 iron binding site [ion binding]; other site 1286170002523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170002524 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170002525 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286170002526 dimerization interface [polypeptide binding]; other site 1286170002527 NMT1/THI5 like; Region: NMT1; pfam09084 1286170002528 amidohydrolase; Provisional; Region: PRK12393 1286170002529 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1286170002530 active site 1286170002531 putative substrate binding pocket [chemical binding]; other site 1286170002532 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1286170002533 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1286170002534 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1286170002535 Sensory domain found in PocR; Region: PocR; pfam10114 1286170002536 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1286170002537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286170002538 Histidine kinase; Region: His_kinase; pfam06580 1286170002539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170002540 Mg2+ binding site [ion binding]; other site 1286170002541 G-X-G motif; other site 1286170002542 Response regulator receiver domain; Region: Response_reg; pfam00072 1286170002543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170002544 active site 1286170002545 phosphorylation site [posttranslational modification] 1286170002546 intermolecular recognition site; other site 1286170002547 dimerization interface [polypeptide binding]; other site 1286170002548 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170002549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170002550 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170002551 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1286170002552 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1286170002553 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1286170002554 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1286170002555 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1286170002556 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1286170002557 Hexamer interface [polypeptide binding]; other site 1286170002558 Hexagonal pore residue; other site 1286170002559 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1286170002560 amphipathic channel; other site 1286170002561 Asn-Pro-Ala signature motifs; other site 1286170002562 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1286170002563 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286170002564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170002565 FeS/SAM binding site; other site 1286170002566 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1286170002567 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1286170002568 dimer interface [polypeptide binding]; other site 1286170002569 active site 1286170002570 glycine loop; other site 1286170002571 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1286170002572 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1286170002573 conserved cys residue [active] 1286170002574 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 1286170002575 Hexamer interface [polypeptide binding]; other site 1286170002576 Hexagonal pore residue; other site 1286170002577 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1286170002578 putative catalytic cysteine [active] 1286170002579 propanediol utilization protein PduB; Provisional; Region: PRK15415 1286170002580 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1286170002581 putative hexamer interface [polypeptide binding]; other site 1286170002582 putative hexagonal pore; other site 1286170002583 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1286170002584 putative hexamer interface [polypeptide binding]; other site 1286170002585 putative hexagonal pore; other site 1286170002586 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1286170002587 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1286170002588 Hexamer interface [polypeptide binding]; other site 1286170002589 Hexagonal pore residue; other site 1286170002590 propionate/acetate kinase; Provisional; Region: PRK12379 1286170002591 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1286170002592 Domain of unknown function (DUF336); Region: DUF336; cl01249 1286170002593 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1286170002594 Hexamer/Pentamer interface [polypeptide binding]; other site 1286170002595 central pore; other site 1286170002596 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 1286170002597 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286170002598 nucleotide binding site [chemical binding]; other site 1286170002599 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286170002600 nucleotide binding site [chemical binding]; other site 1286170002601 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1286170002602 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1286170002603 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1286170002604 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1286170002605 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1286170002606 putative active site [active] 1286170002607 metal binding site [ion binding]; metal-binding site 1286170002608 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1286170002609 homotrimer interaction site [polypeptide binding]; other site 1286170002610 putative active site [active] 1286170002611 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170002612 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170002613 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286170002614 putative effector binding pocket; other site 1286170002615 putative dimerization interface [polypeptide binding]; other site 1286170002616 short chain dehydrogenase; Provisional; Region: PRK06482 1286170002617 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1286170002618 NADP binding site [chemical binding]; other site 1286170002619 active site 1286170002620 steroid binding site; other site 1286170002621 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1286170002622 active site 1286170002623 homotetramer interface [polypeptide binding]; other site 1286170002624 homodimer interface [polypeptide binding]; other site 1286170002625 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1286170002626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286170002627 ATP binding site [chemical binding]; other site 1286170002628 putative Mg++ binding site [ion binding]; other site 1286170002629 AAA domain; Region: AAA_11; pfam13086 1286170002630 Part of AAA domain; Region: AAA_19; pfam13245 1286170002631 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1286170002632 AAA domain; Region: AAA_12; pfam13087 1286170002633 potential frameshift: common BLAST hit: gi|339328455|ref|YP_004688147.1| endocuclease TsnA domain-containing protein 1286170002634 integrase; Provisional; Region: PRK09692 1286170002635 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1286170002636 active site 1286170002637 Int/Topo IB signature motif; other site 1286170002638 GTP-binding protein YchF; Reviewed; Region: PRK09601 1286170002639 YchF GTPase; Region: YchF; cd01900 1286170002640 G1 box; other site 1286170002641 GTP/Mg2+ binding site [chemical binding]; other site 1286170002642 Switch I region; other site 1286170002643 G2 box; other site 1286170002644 Switch II region; other site 1286170002645 G3 box; other site 1286170002646 G4 box; other site 1286170002647 G5 box; other site 1286170002648 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1286170002649 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1286170002650 putative active site [active] 1286170002651 catalytic residue [active] 1286170002652 hypothetical protein; Provisional; Region: PRK10692 1286170002653 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1286170002654 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1286170002655 DNA binding residues [nucleotide binding] 1286170002656 putative dimer interface [polypeptide binding]; other site 1286170002657 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1286170002658 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1286170002659 putative transporter; Provisional; Region: PRK11660 1286170002660 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1286170002661 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1286170002662 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1286170002663 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1286170002664 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1286170002665 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286170002666 active site 1286170002667 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1286170002668 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1286170002669 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1286170002670 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1286170002671 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1286170002672 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1286170002673 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1286170002674 tRNA; other site 1286170002675 putative tRNA binding site [nucleotide binding]; other site 1286170002676 putative NADP binding site [chemical binding]; other site 1286170002677 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1286170002678 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1286170002679 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1286170002680 RF-1 domain; Region: RF-1; pfam00472 1286170002681 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1286170002682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1286170002683 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 1286170002684 hypothetical protein; Provisional; Region: PRK10941 1286170002685 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1286170002686 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1286170002687 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1286170002688 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1286170002689 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1286170002690 cation transport regulator; Reviewed; Region: chaB; PRK09582 1286170002691 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1286170002692 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1286170002693 putative active site pocket [active] 1286170002694 dimerization interface [polypeptide binding]; other site 1286170002695 putative catalytic residue [active] 1286170002696 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1286170002697 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1286170002698 Nitrate and nitrite sensing; Region: NIT; pfam08376 1286170002699 ANTAR domain; Region: ANTAR; pfam03861 1286170002700 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1286170002701 NMT1-like family; Region: NMT1_2; pfam13379 1286170002702 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286170002703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170002704 dimer interface [polypeptide binding]; other site 1286170002705 conserved gate region; other site 1286170002706 putative PBP binding loops; other site 1286170002707 ABC-ATPase subunit interface; other site 1286170002708 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286170002709 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286170002710 Walker A/P-loop; other site 1286170002711 ATP binding site [chemical binding]; other site 1286170002712 Q-loop/lid; other site 1286170002713 ABC transporter signature motif; other site 1286170002714 Walker B; other site 1286170002715 D-loop; other site 1286170002716 H-loop/switch region; other site 1286170002717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1286170002718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170002719 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1286170002720 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170002721 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170002722 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286170002723 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1286170002724 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1286170002725 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1286170002726 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1286170002727 [4Fe-4S] binding site [ion binding]; other site 1286170002728 molybdopterin cofactor binding site; other site 1286170002729 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1286170002730 molybdopterin cofactor binding site; other site 1286170002731 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286170002732 putative invasin; Provisional; Region: PRK10177 1286170002733 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1286170002734 transcriptional regulator NarL; Provisional; Region: PRK10651 1286170002735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170002736 active site 1286170002737 phosphorylation site [posttranslational modification] 1286170002738 intermolecular recognition site; other site 1286170002739 dimerization interface [polypeptide binding]; other site 1286170002740 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170002741 DNA binding residues [nucleotide binding] 1286170002742 dimerization interface [polypeptide binding]; other site 1286170002743 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1286170002744 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1286170002745 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286170002746 dimerization interface [polypeptide binding]; other site 1286170002747 Histidine kinase; Region: HisKA_3; pfam07730 1286170002748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170002749 ATP binding site [chemical binding]; other site 1286170002750 Mg2+ binding site [ion binding]; other site 1286170002751 G-X-G motif; other site 1286170002752 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1286170002753 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1286170002754 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1286170002755 [4Fe-4S] binding site [ion binding]; other site 1286170002756 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170002757 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170002758 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170002759 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1286170002760 molybdopterin cofactor binding site; other site 1286170002761 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1286170002762 4Fe-4S binding domain; Region: Fer4; cl02805 1286170002763 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1286170002764 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1286170002765 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286170002766 EamA-like transporter family; Region: EamA; pfam00892 1286170002767 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286170002768 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1286170002769 AsnC family; Region: AsnC_trans_reg; pfam01037 1286170002770 potential protein location (hypothetical protein RORB6_03915 [Raoultella ornithinolytica B6]) that overlaps RNA (tRNA-Y) 1286170002771 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1286170002772 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1286170002773 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1286170002774 putative active site [active] 1286170002775 putative substrate binding site [chemical binding]; other site 1286170002776 putative cosubstrate binding site; other site 1286170002777 catalytic site [active] 1286170002778 hypothetical protein; Provisional; Region: PRK04233 1286170002779 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1286170002780 hypothetical protein; Provisional; Region: PRK10279 1286170002781 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1286170002782 nucleophile elbow; other site 1286170002783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170002784 active site 1286170002785 response regulator of RpoS; Provisional; Region: PRK10693 1286170002786 phosphorylation site [posttranslational modification] 1286170002787 intermolecular recognition site; other site 1286170002788 dimerization interface [polypeptide binding]; other site 1286170002789 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1286170002790 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1286170002791 active site 1286170002792 tetramer interface; other site 1286170002793 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1286170002794 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1286170002795 thymidine kinase; Provisional; Region: PRK04296 1286170002796 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1286170002797 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1286170002798 putative catalytic cysteine [active] 1286170002799 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1286170002800 putative active site [active] 1286170002801 metal binding site [ion binding]; metal-binding site 1286170002802 hypothetical protein; Provisional; Region: PRK11111 1286170002803 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1286170002804 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286170002805 peptide binding site [polypeptide binding]; other site 1286170002806 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1286170002807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170002808 dimer interface [polypeptide binding]; other site 1286170002809 conserved gate region; other site 1286170002810 putative PBP binding loops; other site 1286170002811 ABC-ATPase subunit interface; other site 1286170002812 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1286170002813 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1286170002814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170002815 dimer interface [polypeptide binding]; other site 1286170002816 conserved gate region; other site 1286170002817 ABC-ATPase subunit interface; other site 1286170002818 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1286170002819 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170002820 Walker A/P-loop; other site 1286170002821 ATP binding site [chemical binding]; other site 1286170002822 Q-loop/lid; other site 1286170002823 ABC transporter signature motif; other site 1286170002824 Walker B; other site 1286170002825 D-loop; other site 1286170002826 H-loop/switch region; other site 1286170002827 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286170002828 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1286170002829 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170002830 Walker A/P-loop; other site 1286170002831 ATP binding site [chemical binding]; other site 1286170002832 Q-loop/lid; other site 1286170002833 ABC transporter signature motif; other site 1286170002834 Walker B; other site 1286170002835 D-loop; other site 1286170002836 H-loop/switch region; other site 1286170002837 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286170002838 Ion transport protein; Region: Ion_trans; pfam00520 1286170002839 Ion channel; Region: Ion_trans_2; pfam07885 1286170002840 Double zinc ribbon; Region: DZR; pfam12773 1286170002841 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1286170002842 dsDNA-mimic protein; Reviewed; Region: PRK05094 1286170002843 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1286170002844 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1286170002845 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1286170002846 putative active site [active] 1286170002847 catalytic site [active] 1286170002848 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1286170002849 putative active site [active] 1286170002850 catalytic site [active] 1286170002851 YciI-like protein; Reviewed; Region: PRK11370 1286170002852 transport protein TonB; Provisional; Region: PRK10819 1286170002853 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1286170002854 Phosphotransferase enzyme family; Region: APH; pfam01636 1286170002855 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1286170002856 active site 1286170002857 ATP binding site [chemical binding]; other site 1286170002858 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286170002859 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1286170002860 6-phosphofructokinase 2; Provisional; Region: PRK10294 1286170002861 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1286170002862 putative substrate binding site [chemical binding]; other site 1286170002863 putative ATP binding site [chemical binding]; other site 1286170002864 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1286170002865 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1286170002866 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1286170002867 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1286170002868 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1286170002869 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1286170002870 active site 1286170002871 dimer interface [polypeptide binding]; other site 1286170002872 motif 1; other site 1286170002873 motif 2; other site 1286170002874 motif 3; other site 1286170002875 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1286170002876 anticodon binding site; other site 1286170002877 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1286170002878 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1286170002879 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1286170002880 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1286170002881 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1286170002882 23S rRNA binding site [nucleotide binding]; other site 1286170002883 L21 binding site [polypeptide binding]; other site 1286170002884 L13 binding site [polypeptide binding]; other site 1286170002885 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1286170002886 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1286170002887 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1286170002888 dimer interface [polypeptide binding]; other site 1286170002889 motif 1; other site 1286170002890 active site 1286170002891 motif 2; other site 1286170002892 motif 3; other site 1286170002893 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1286170002894 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1286170002895 putative tRNA-binding site [nucleotide binding]; other site 1286170002896 B3/4 domain; Region: B3_4; pfam03483 1286170002897 tRNA synthetase B5 domain; Region: B5; smart00874 1286170002898 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1286170002899 dimer interface [polypeptide binding]; other site 1286170002900 motif 1; other site 1286170002901 motif 3; other site 1286170002902 motif 2; other site 1286170002903 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1286170002904 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286170002905 IHF dimer interface [polypeptide binding]; other site 1286170002906 IHF - DNA interface [nucleotide binding]; other site 1286170002907 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1286170002908 homotrimer interaction site [polypeptide binding]; other site 1286170002909 putative active site [active] 1286170002910 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1286170002911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170002912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170002913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286170002914 dimerization interface [polypeptide binding]; other site 1286170002915 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 1286170002916 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286170002917 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170002918 ABC-ATPase subunit interface; other site 1286170002919 dimer interface [polypeptide binding]; other site 1286170002920 putative PBP binding regions; other site 1286170002921 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1286170002922 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1286170002923 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1286170002924 catalytic residues [active] 1286170002925 dimer interface [polypeptide binding]; other site 1286170002926 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1286170002927 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286170002928 Walker A/P-loop; other site 1286170002929 ATP binding site [chemical binding]; other site 1286170002930 Q-loop/lid; other site 1286170002931 ABC transporter signature motif; other site 1286170002932 Walker B; other site 1286170002933 D-loop; other site 1286170002934 H-loop/switch region; other site 1286170002935 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1286170002936 NlpC/P60 family; Region: NLPC_P60; pfam00877 1286170002937 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1286170002938 hypothetical protein; Validated; Region: PRK00029 1286170002939 hypothetical protein; Provisional; Region: PRK10183 1286170002940 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1286170002941 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1286170002942 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1286170002943 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1286170002944 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1286170002945 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1286170002946 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1286170002947 putative inner membrane protein; Provisional; Region: PRK10983 1286170002948 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286170002949 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286170002950 FAD binding domain; Region: FAD_binding_4; pfam01565 1286170002951 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1286170002952 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1286170002953 CoenzymeA binding site [chemical binding]; other site 1286170002954 subunit interaction site [polypeptide binding]; other site 1286170002955 PHB binding site; other site 1286170002956 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1286170002957 hypothetical protein; Provisional; Region: PRK10457 1286170002958 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1286170002959 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1286170002960 putative ABC transporter; Region: ycf24; CHL00085 1286170002961 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1286170002962 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1286170002963 Walker A/P-loop; other site 1286170002964 ATP binding site [chemical binding]; other site 1286170002965 Q-loop/lid; other site 1286170002966 ABC transporter signature motif; other site 1286170002967 Walker B; other site 1286170002968 D-loop; other site 1286170002969 H-loop/switch region; other site 1286170002970 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1286170002971 FeS assembly protein SufD; Region: sufD; TIGR01981 1286170002972 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1286170002973 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1286170002974 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286170002975 catalytic residue [active] 1286170002976 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1286170002977 L,D-transpeptidase; Provisional; Region: PRK10190 1286170002978 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286170002979 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286170002980 murein lipoprotein; Provisional; Region: PRK15396 1286170002981 pyruvate kinase; Provisional; Region: PRK09206 1286170002982 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1286170002983 domain interfaces; other site 1286170002984 active site 1286170002985 hypothetical protein; Provisional; Region: PRK10292 1286170002986 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1286170002987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170002988 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286170002989 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1286170002990 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1286170002991 dimer interface [polypeptide binding]; other site 1286170002992 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1286170002993 active site 1286170002994 Fe binding site [ion binding]; other site 1286170002995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170002996 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170002997 putative substrate translocation pore; other site 1286170002998 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1286170002999 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1286170003000 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1286170003001 shikimate binding site; other site 1286170003002 NAD(P) binding site [chemical binding]; other site 1286170003003 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286170003004 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286170003005 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286170003006 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1286170003007 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286170003008 Walker A/P-loop; other site 1286170003009 ATP binding site [chemical binding]; other site 1286170003010 Q-loop/lid; other site 1286170003011 ABC transporter signature motif; other site 1286170003012 Walker B; other site 1286170003013 D-loop; other site 1286170003014 H-loop/switch region; other site 1286170003015 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286170003016 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170003017 ABC-ATPase subunit interface; other site 1286170003018 dimer interface [polypeptide binding]; other site 1286170003019 putative PBP binding regions; other site 1286170003020 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1286170003021 putative ligand binding residues [chemical binding]; other site 1286170003022 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1286170003023 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1286170003024 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1286170003025 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286170003026 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1286170003027 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286170003028 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 1286170003029 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1286170003030 putative active site [active] 1286170003031 Fe(II) binding site [ion binding]; other site 1286170003032 putative dimer interface [polypeptide binding]; other site 1286170003033 putative tetramer interface [polypeptide binding]; other site 1286170003034 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1286170003035 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1286170003036 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 1286170003037 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1286170003038 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1286170003039 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1286170003040 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1286170003041 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1286170003042 active site 1286170003043 catalytic residues [active] 1286170003044 metal binding site [ion binding]; metal-binding site 1286170003045 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1286170003046 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1286170003047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003048 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1286170003049 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 1286170003050 active site residue [active] 1286170003051 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1286170003052 active site residue [active] 1286170003053 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1286170003054 active site residue [active] 1286170003055 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 1286170003056 active site residue [active] 1286170003057 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1286170003058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170003059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003060 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1286170003061 dimerization interface [polypeptide binding]; other site 1286170003062 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1286170003063 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1286170003064 dimer interface [polypeptide binding]; other site 1286170003065 active site 1286170003066 non-prolyl cis peptide bond; other site 1286170003067 insertion regions; other site 1286170003068 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1286170003069 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1286170003070 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1286170003071 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1286170003072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170003073 membrane-bound complex binding site; other site 1286170003074 NMT1-like family; Region: NMT1_2; pfam13379 1286170003075 NMT1/THI5 like; Region: NMT1; pfam09084 1286170003076 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286170003077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170003078 dimer interface [polypeptide binding]; other site 1286170003079 conserved gate region; other site 1286170003080 putative PBP binding loops; other site 1286170003081 ABC-ATPase subunit interface; other site 1286170003082 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286170003083 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286170003084 Walker A/P-loop; other site 1286170003085 ATP binding site [chemical binding]; other site 1286170003086 Q-loop/lid; other site 1286170003087 ABC transporter signature motif; other site 1286170003088 Walker B; other site 1286170003089 D-loop; other site 1286170003090 H-loop/switch region; other site 1286170003091 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1286170003092 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170003093 N-terminal plug; other site 1286170003094 ligand-binding site [chemical binding]; other site 1286170003095 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1286170003096 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286170003097 Walker A/P-loop; other site 1286170003098 ATP binding site [chemical binding]; other site 1286170003099 Q-loop/lid; other site 1286170003100 ABC transporter signature motif; other site 1286170003101 Walker B; other site 1286170003102 D-loop; other site 1286170003103 H-loop/switch region; other site 1286170003104 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286170003105 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170003106 ABC-ATPase subunit interface; other site 1286170003107 dimer interface [polypeptide binding]; other site 1286170003108 putative PBP binding regions; other site 1286170003109 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1286170003110 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170003111 ABC-ATPase subunit interface; other site 1286170003112 dimer interface [polypeptide binding]; other site 1286170003113 putative PBP binding regions; other site 1286170003114 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1286170003115 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1286170003116 siderophore binding site; other site 1286170003117 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286170003118 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170003119 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170003120 putative active site [active] 1286170003121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170003122 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170003123 substrate binding pocket [chemical binding]; other site 1286170003124 membrane-bound complex binding site; other site 1286170003125 hinge residues; other site 1286170003126 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170003127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170003128 dimer interface [polypeptide binding]; other site 1286170003129 conserved gate region; other site 1286170003130 putative PBP binding loops; other site 1286170003131 ABC-ATPase subunit interface; other site 1286170003132 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286170003133 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286170003134 Walker A/P-loop; other site 1286170003135 ATP binding site [chemical binding]; other site 1286170003136 Q-loop/lid; other site 1286170003137 ABC transporter signature motif; other site 1286170003138 Walker B; other site 1286170003139 D-loop; other site 1286170003140 H-loop/switch region; other site 1286170003141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003142 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170003143 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1286170003144 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286170003145 metal binding site [ion binding]; metal-binding site 1286170003146 putative dimer interface [polypeptide binding]; other site 1286170003147 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1286170003148 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1286170003149 [4Fe-4S] binding site [ion binding]; other site 1286170003150 molybdopterin cofactor binding site; other site 1286170003151 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1286170003152 molybdopterin cofactor binding site; other site 1286170003153 putative dehydrogenase; Provisional; Region: PRK10098 1286170003154 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170003155 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1286170003156 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1286170003157 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1286170003158 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 1286170003159 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 1286170003160 Uncharacterized conserved protein [Function unknown]; Region: COG3350 1286170003161 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1286170003162 FtsX-like permease family; Region: FtsX; pfam02687 1286170003163 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286170003164 FtsX-like permease family; Region: FtsX; pfam02687 1286170003165 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286170003166 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286170003167 Walker A/P-loop; other site 1286170003168 ATP binding site [chemical binding]; other site 1286170003169 Q-loop/lid; other site 1286170003170 ABC transporter signature motif; other site 1286170003171 Walker B; other site 1286170003172 D-loop; other site 1286170003173 H-loop/switch region; other site 1286170003174 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1286170003175 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286170003176 catalytic residues [active] 1286170003177 hypothetical protein; Provisional; Region: PRK07490 1286170003178 intersubunit interface [polypeptide binding]; other site 1286170003179 active site 1286170003180 Zn2+ binding site [ion binding]; other site 1286170003181 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170003182 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170003183 substrate binding pocket [chemical binding]; other site 1286170003184 membrane-bound complex binding site; other site 1286170003185 hinge residues; other site 1286170003186 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1286170003187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170003188 dimer interface [polypeptide binding]; other site 1286170003189 conserved gate region; other site 1286170003190 putative PBP binding loops; other site 1286170003191 ABC-ATPase subunit interface; other site 1286170003192 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286170003193 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286170003194 Walker A/P-loop; other site 1286170003195 ATP binding site [chemical binding]; other site 1286170003196 Q-loop/lid; other site 1286170003197 ABC transporter signature motif; other site 1286170003198 Walker B; other site 1286170003199 D-loop; other site 1286170003200 H-loop/switch region; other site 1286170003201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170003202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003203 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1286170003204 putative substrate binding pocket [chemical binding]; other site 1286170003205 dimerization interface [polypeptide binding]; other site 1286170003206 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1286170003207 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286170003208 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286170003209 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286170003210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170003211 dimer interface [polypeptide binding]; other site 1286170003212 conserved gate region; other site 1286170003213 ABC-ATPase subunit interface; other site 1286170003214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170003215 dimer interface [polypeptide binding]; other site 1286170003216 conserved gate region; other site 1286170003217 putative PBP binding loops; other site 1286170003218 ABC-ATPase subunit interface; other site 1286170003219 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286170003220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170003221 Walker A/P-loop; other site 1286170003222 ATP binding site [chemical binding]; other site 1286170003223 Q-loop/lid; other site 1286170003224 ABC transporter signature motif; other site 1286170003225 Walker B; other site 1286170003226 D-loop; other site 1286170003227 H-loop/switch region; other site 1286170003228 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1286170003229 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1286170003230 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1286170003231 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1286170003232 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286170003233 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286170003234 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286170003235 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1286170003236 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1286170003237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170003238 Walker A/P-loop; other site 1286170003239 ATP binding site [chemical binding]; other site 1286170003240 Q-loop/lid; other site 1286170003241 ABC transporter signature motif; other site 1286170003242 Walker B; other site 1286170003243 D-loop; other site 1286170003244 H-loop/switch region; other site 1286170003245 heme exporter protein CcmB; Region: ccmB; TIGR01190 1286170003246 heme exporter protein CcmC; Region: ccmC; TIGR01191 1286170003247 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1286170003248 CcmE; Region: CcmE; cl00994 1286170003249 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1286170003250 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1286170003251 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286170003252 catalytic residues [active] 1286170003253 central insert; other site 1286170003254 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1286170003255 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1286170003256 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1286170003257 acetoin reductase; Validated; Region: PRK08643 1286170003258 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1286170003259 NAD binding site [chemical binding]; other site 1286170003260 homotetramer interface [polypeptide binding]; other site 1286170003261 homodimer interface [polypeptide binding]; other site 1286170003262 active site 1286170003263 substrate binding site [chemical binding]; other site 1286170003264 acetolactate synthase; Reviewed; Region: PRK08617 1286170003265 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286170003266 PYR/PP interface [polypeptide binding]; other site 1286170003267 dimer interface [polypeptide binding]; other site 1286170003268 TPP binding site [chemical binding]; other site 1286170003269 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286170003270 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1286170003271 TPP-binding site [chemical binding]; other site 1286170003272 dimer interface [polypeptide binding]; other site 1286170003273 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1286170003274 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1286170003275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003276 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1286170003277 putative dimerization interface [polypeptide binding]; other site 1286170003278 putative substrate binding pocket [chemical binding]; other site 1286170003279 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286170003280 DNA-binding site [nucleotide binding]; DNA binding site 1286170003281 RNA-binding motif; other site 1286170003282 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286170003283 DNA-binding site [nucleotide binding]; DNA binding site 1286170003284 RNA-binding motif; other site 1286170003285 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1286170003286 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1286170003287 NAD binding site [chemical binding]; other site 1286170003288 homotetramer interface [polypeptide binding]; other site 1286170003289 homodimer interface [polypeptide binding]; other site 1286170003290 substrate binding site [chemical binding]; other site 1286170003291 active site 1286170003292 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1286170003293 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1286170003294 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1286170003295 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286170003296 putative acyltransferase; Provisional; Region: PRK05790 1286170003297 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286170003298 dimer interface [polypeptide binding]; other site 1286170003299 active site 1286170003300 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1286170003301 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1286170003302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170003303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003304 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1286170003305 putative dimerization interface [polypeptide binding]; other site 1286170003306 Protein of unknown function (DUF535); Region: DUF535; cl01128 1286170003307 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1286170003308 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1286170003309 Trp docking motif [polypeptide binding]; other site 1286170003310 putative active site [active] 1286170003311 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1286170003312 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170003313 Walker A/P-loop; other site 1286170003314 ATP binding site [chemical binding]; other site 1286170003315 Q-loop/lid; other site 1286170003316 ABC transporter signature motif; other site 1286170003317 Walker B; other site 1286170003318 D-loop; other site 1286170003319 H-loop/switch region; other site 1286170003320 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286170003321 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286170003322 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170003323 Walker A/P-loop; other site 1286170003324 ATP binding site [chemical binding]; other site 1286170003325 Q-loop/lid; other site 1286170003326 ABC transporter signature motif; other site 1286170003327 Walker B; other site 1286170003328 D-loop; other site 1286170003329 H-loop/switch region; other site 1286170003330 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286170003331 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286170003332 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1286170003333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170003334 dimer interface [polypeptide binding]; other site 1286170003335 conserved gate region; other site 1286170003336 putative PBP binding loops; other site 1286170003337 ABC-ATPase subunit interface; other site 1286170003338 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286170003339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170003340 dimer interface [polypeptide binding]; other site 1286170003341 conserved gate region; other site 1286170003342 putative PBP binding loops; other site 1286170003343 ABC-ATPase subunit interface; other site 1286170003344 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286170003345 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1286170003346 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1286170003347 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1286170003348 Walker A/P-loop; other site 1286170003349 ATP binding site [chemical binding]; other site 1286170003350 Q-loop/lid; other site 1286170003351 ABC transporter signature motif; other site 1286170003352 Walker B; other site 1286170003353 D-loop; other site 1286170003354 H-loop/switch region; other site 1286170003355 NIL domain; Region: NIL; pfam09383 1286170003356 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1286170003357 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1286170003358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170003359 dimer interface [polypeptide binding]; other site 1286170003360 conserved gate region; other site 1286170003361 ABC-ATPase subunit interface; other site 1286170003362 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1286170003363 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286170003364 active site 1286170003365 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 1286170003366 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1286170003367 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286170003368 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286170003369 dimerization interface [polypeptide binding]; other site 1286170003370 putative DNA binding site [nucleotide binding]; other site 1286170003371 putative Zn2+ binding site [ion binding]; other site 1286170003372 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1286170003373 arsenical pump membrane protein; Provisional; Region: PRK15445 1286170003374 transmembrane helices; other site 1286170003375 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1286170003376 ArsC family; Region: ArsC; pfam03960 1286170003377 catalytic residues [active] 1286170003378 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1286170003379 Chloramphenicol acetyltransferase; Region: CAT; cl02008 1286170003380 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286170003381 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286170003382 active site 1286170003383 metal binding site [ion binding]; metal-binding site 1286170003384 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286170003385 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1286170003386 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286170003387 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1286170003388 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1286170003389 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286170003390 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1286170003391 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1286170003392 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1286170003393 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1286170003394 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286170003395 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170003396 molybdopterin cofactor binding site; other site 1286170003397 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1286170003398 molybdopterin cofactor binding site; other site 1286170003399 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170003400 xanthine permease; Region: pbuX; TIGR03173 1286170003401 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 1286170003402 4Fe-4S binding domain; Region: Fer4; pfam00037 1286170003403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170003404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170003405 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1286170003406 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 1286170003407 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286170003408 active site 1286170003409 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 1286170003410 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1286170003411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170003412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170003413 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1286170003414 Ligand binding site; other site 1286170003415 metal-binding site 1286170003416 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 1286170003417 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1286170003418 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1286170003419 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1286170003420 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 1286170003421 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1286170003422 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1286170003423 carbamate kinase; Reviewed; Region: PRK12686 1286170003424 putative substrate binding site [chemical binding]; other site 1286170003425 homodimer interface [polypeptide binding]; other site 1286170003426 nucleotide binding site [chemical binding]; other site 1286170003427 nucleotide binding site [chemical binding]; other site 1286170003428 phenylhydantoinase; Validated; Region: PRK08323 1286170003429 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1286170003430 tetramer interface [polypeptide binding]; other site 1286170003431 active site 1286170003432 peptidase; Reviewed; Region: PRK13004 1286170003433 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 1286170003434 putative metal binding site [ion binding]; other site 1286170003435 putative dimer interface [polypeptide binding]; other site 1286170003436 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1286170003437 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1286170003438 catalytic residue [active] 1286170003439 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 1286170003440 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1286170003441 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1286170003442 GAF domain; Region: GAF; cl17456 1286170003443 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1286170003444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286170003445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170003446 Walker A motif; other site 1286170003447 ATP binding site [chemical binding]; other site 1286170003448 Walker B motif; other site 1286170003449 arginine finger; other site 1286170003450 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286170003451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170003452 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1286170003453 active site clefts [active] 1286170003454 zinc binding site [ion binding]; other site 1286170003455 dimer interface [polypeptide binding]; other site 1286170003456 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286170003457 hypothetical protein; Provisional; Region: PRK09897 1286170003458 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1286170003459 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286170003460 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1286170003461 C-terminal domain interface [polypeptide binding]; other site 1286170003462 GSH binding site (G-site) [chemical binding]; other site 1286170003463 dimer interface [polypeptide binding]; other site 1286170003464 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1286170003465 N-terminal domain interface [polypeptide binding]; other site 1286170003466 substrate binding pocket (H-site) [chemical binding]; other site 1286170003467 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286170003468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003469 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1286170003470 dimerization interface [polypeptide binding]; other site 1286170003471 substrate binding pocket [chemical binding]; other site 1286170003472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170003473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003474 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286170003475 putative effector binding pocket; other site 1286170003476 putative dimerization interface [polypeptide binding]; other site 1286170003477 SnoaL-like domain; Region: SnoaL_2; pfam12680 1286170003478 short chain dehydrogenase; Provisional; Region: PRK06523 1286170003479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170003480 NAD(P) binding site [chemical binding]; other site 1286170003481 active site 1286170003482 RES domain; Region: RES; cl02411 1286170003483 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1286170003484 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1286170003485 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1286170003486 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1286170003487 conserved cys residue [active] 1286170003488 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 1286170003489 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1286170003490 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1286170003491 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1286170003492 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1286170003493 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1286170003494 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170003495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003496 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170003497 dimerization interface [polypeptide binding]; other site 1286170003498 multidrug efflux protein; Reviewed; Region: PRK01766 1286170003499 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1286170003500 cation binding site [ion binding]; other site 1286170003501 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1286170003502 Lumazine binding domain; Region: Lum_binding; pfam00677 1286170003503 Lumazine binding domain; Region: Lum_binding; pfam00677 1286170003504 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1286170003505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170003506 S-adenosylmethionine binding site [chemical binding]; other site 1286170003507 putative transporter; Provisional; Region: PRK11043 1286170003508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003509 putative substrate translocation pore; other site 1286170003510 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1286170003511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003512 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170003513 dimerization interface [polypeptide binding]; other site 1286170003514 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1286170003515 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170003516 DNA binding site [nucleotide binding] 1286170003517 domain linker motif; other site 1286170003518 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1286170003519 dimerization interface [polypeptide binding]; other site 1286170003520 ligand binding site [chemical binding]; other site 1286170003521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170003523 putative substrate translocation pore; other site 1286170003524 superoxide dismutase; Provisional; Region: PRK10543 1286170003525 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1286170003526 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1286170003527 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286170003528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170003529 Coenzyme A binding pocket [chemical binding]; other site 1286170003530 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1286170003531 NlpC/P60 family; Region: NLPC_P60; pfam00877 1286170003532 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1286170003533 putative GSH binding site [chemical binding]; other site 1286170003534 catalytic residues [active] 1286170003535 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1286170003536 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1286170003537 dimer interface [polypeptide binding]; other site 1286170003538 catalytic site [active] 1286170003539 putative active site [active] 1286170003540 putative substrate binding site [chemical binding]; other site 1286170003541 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286170003542 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1286170003543 dimer interface [polypeptide binding]; other site 1286170003544 active site 1286170003545 metal binding site [ion binding]; metal-binding site 1286170003546 glutathione binding site [chemical binding]; other site 1286170003547 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1286170003548 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1286170003549 FMN binding site [chemical binding]; other site 1286170003550 active site 1286170003551 substrate binding site [chemical binding]; other site 1286170003552 catalytic residue [active] 1286170003553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286170003554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170003555 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1286170003556 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170003557 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170003558 active site 1286170003559 catalytic tetrad [active] 1286170003560 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1286170003561 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1286170003562 E-class dimer interface [polypeptide binding]; other site 1286170003563 P-class dimer interface [polypeptide binding]; other site 1286170003564 active site 1286170003565 Cu2+ binding site [ion binding]; other site 1286170003566 Zn2+ binding site [ion binding]; other site 1286170003567 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1286170003568 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1286170003569 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1286170003570 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170003571 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170003572 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1286170003573 transcriptional regulator SlyA; Provisional; Region: PRK03573 1286170003574 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1286170003575 DIE2/ALG10 family; Region: DIE2_ALG10; pfam04922 1286170003576 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170003577 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170003578 metal binding site [ion binding]; metal-binding site 1286170003579 active site 1286170003580 I-site; other site 1286170003581 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1286170003582 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1286170003583 lysozyme inhibitor; Provisional; Region: PRK11372 1286170003584 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1286170003585 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1286170003586 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1286170003587 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1286170003588 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1286170003589 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1286170003590 active site 1286170003591 HIGH motif; other site 1286170003592 dimer interface [polypeptide binding]; other site 1286170003593 KMSKS motif; other site 1286170003594 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286170003595 RNA binding surface [nucleotide binding]; other site 1286170003596 pyridoxamine kinase; Validated; Region: PRK05756 1286170003597 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1286170003598 dimer interface [polypeptide binding]; other site 1286170003599 pyridoxal binding site [chemical binding]; other site 1286170003600 ATP binding site [chemical binding]; other site 1286170003601 glutathionine S-transferase; Provisional; Region: PRK10542 1286170003602 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1286170003603 C-terminal domain interface [polypeptide binding]; other site 1286170003604 GSH binding site (G-site) [chemical binding]; other site 1286170003605 dimer interface [polypeptide binding]; other site 1286170003606 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1286170003607 N-terminal domain interface [polypeptide binding]; other site 1286170003608 dimer interface [polypeptide binding]; other site 1286170003609 substrate binding pocket (H-site) [chemical binding]; other site 1286170003610 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1286170003611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003612 putative substrate translocation pore; other site 1286170003613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003614 endonuclease III; Provisional; Region: PRK10702 1286170003615 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1286170003616 minor groove reading motif; other site 1286170003617 helix-hairpin-helix signature motif; other site 1286170003618 substrate binding pocket [chemical binding]; other site 1286170003619 active site 1286170003620 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1286170003621 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1286170003622 electron transport complex protein RnfG; Validated; Region: PRK01908 1286170003623 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1286170003624 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1286170003625 SLBB domain; Region: SLBB; pfam10531 1286170003626 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286170003627 electron transport complex protein RnfB; Provisional; Region: PRK05113 1286170003628 Putative Fe-S cluster; Region: FeS; cl17515 1286170003629 4Fe-4S binding domain; Region: Fer4; pfam00037 1286170003630 electron transport complex protein RsxA; Provisional; Region: PRK05151 1286170003631 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1286170003632 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1286170003633 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1286170003634 beta-galactosidase; Region: BGL; TIGR03356 1286170003635 putative oxidoreductase; Provisional; Region: PRK11579 1286170003636 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286170003637 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286170003638 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1286170003639 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1286170003640 active site 1286170003641 purine riboside binding site [chemical binding]; other site 1286170003642 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170003643 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170003644 metal binding site [ion binding]; metal-binding site 1286170003645 active site 1286170003646 I-site; other site 1286170003647 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1286170003648 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1286170003649 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1286170003650 CPxP motif; other site 1286170003651 putative inner membrane protein; Provisional; Region: PRK11099 1286170003652 YdfZ protein; Region: YdfZ; pfam14001 1286170003653 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1286170003654 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1286170003655 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1286170003656 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1286170003657 Cl binding site [ion binding]; other site 1286170003658 oligomer interface [polypeptide binding]; other site 1286170003659 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1286170003660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170003661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170003662 homodimer interface [polypeptide binding]; other site 1286170003663 catalytic residue [active] 1286170003664 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1286170003665 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1286170003666 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170003667 active site turn [active] 1286170003668 phosphorylation site [posttranslational modification] 1286170003669 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1286170003670 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170003671 DNA binding site [nucleotide binding] 1286170003672 domain linker motif; other site 1286170003673 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1286170003674 putative dimerization interface [polypeptide binding]; other site 1286170003675 putative ligand binding site [chemical binding]; other site 1286170003676 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1286170003677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1286170003678 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1286170003679 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1286170003680 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1286170003681 fumarate hydratase; Provisional; Region: PRK15389 1286170003682 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1286170003683 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1286170003684 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1286170003685 Class II fumarases; Region: Fumarase_classII; cd01362 1286170003686 active site 1286170003687 tetramer interface [polypeptide binding]; other site 1286170003688 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1286170003689 sensor protein RstB; Provisional; Region: PRK10604 1286170003690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286170003691 dimerization interface [polypeptide binding]; other site 1286170003692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170003693 dimer interface [polypeptide binding]; other site 1286170003694 phosphorylation site [posttranslational modification] 1286170003695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170003696 ATP binding site [chemical binding]; other site 1286170003697 Mg2+ binding site [ion binding]; other site 1286170003698 G-X-G motif; other site 1286170003699 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286170003700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170003702 dimerization interface [polypeptide binding]; other site 1286170003703 Y-family of DNA polymerases; Region: PolY; cl12025 1286170003704 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1286170003705 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1286170003706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170003707 active site 1286170003708 phosphorylation site [posttranslational modification] 1286170003709 intermolecular recognition site; other site 1286170003710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170003711 DNA binding site [nucleotide binding] 1286170003712 GlpM protein; Region: GlpM; pfam06942 1286170003713 dihydromonapterin reductase; Provisional; Region: PRK06483 1286170003714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170003715 NAD(P) binding site [chemical binding]; other site 1286170003716 active site 1286170003717 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1286170003718 Spore germination protein; Region: Spore_permease; cl17796 1286170003719 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1286170003720 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1286170003721 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1286170003722 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1286170003723 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1286170003724 ligand binding site [chemical binding]; other site 1286170003725 homodimer interface [polypeptide binding]; other site 1286170003726 NAD(P) binding site [chemical binding]; other site 1286170003727 trimer interface B [polypeptide binding]; other site 1286170003728 trimer interface A [polypeptide binding]; other site 1286170003729 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1286170003730 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1286170003731 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1286170003732 universal stress protein UspE; Provisional; Region: PRK11175 1286170003733 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286170003734 Ligand Binding Site [chemical binding]; other site 1286170003735 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286170003736 Ligand Binding Site [chemical binding]; other site 1286170003737 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1286170003738 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286170003739 ligand binding site [chemical binding]; other site 1286170003740 flexible hinge region; other site 1286170003741 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286170003742 putative switch regulator; other site 1286170003743 non-specific DNA interactions [nucleotide binding]; other site 1286170003744 DNA binding site [nucleotide binding] 1286170003745 sequence specific DNA binding site [nucleotide binding]; other site 1286170003746 putative cAMP binding site [chemical binding]; other site 1286170003747 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1286170003748 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1286170003749 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1286170003750 DNA binding site [nucleotide binding] 1286170003751 active site 1286170003752 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 1286170003753 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1286170003754 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1286170003755 amidohydrolase; Region: amidohydrolases; TIGR01891 1286170003756 putative metal binding site [ion binding]; other site 1286170003757 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 1286170003758 amidohydrolase; Region: amidohydrolases; TIGR01891 1286170003759 putative metal binding site [ion binding]; other site 1286170003760 dimer interface [polypeptide binding]; other site 1286170003761 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1286170003762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003763 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170003764 dimerization interface [polypeptide binding]; other site 1286170003765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1286170003766 Smr domain; Region: Smr; pfam01713 1286170003767 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1286170003768 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286170003769 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286170003770 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 1286170003771 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1286170003772 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1286170003773 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286170003774 dimer interface [polypeptide binding]; other site 1286170003775 active site 1286170003776 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1286170003777 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1286170003778 tetramer interface [polypeptide binding]; other site 1286170003779 active site 1286170003780 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1286170003781 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1286170003782 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1286170003783 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286170003784 MarR family; Region: MarR_2; cl17246 1286170003785 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286170003786 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1286170003787 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170003788 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170003789 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1286170003790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003791 putative substrate translocation pore; other site 1286170003792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003793 fumarate hydratase; Provisional; Region: PRK15389 1286170003794 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1286170003795 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1286170003796 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1286170003797 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1286170003798 transmembrane helices; other site 1286170003799 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1286170003800 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1286170003801 putative active site [active] 1286170003802 putative FMN binding site [chemical binding]; other site 1286170003803 putative substrate binding site [chemical binding]; other site 1286170003804 putative catalytic residue [active] 1286170003805 FMN-binding domain; Region: FMN_bind; cl01081 1286170003806 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 1286170003807 L-aspartate oxidase; Provisional; Region: PRK06175 1286170003808 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1286170003809 ApbE family; Region: ApbE; pfam02424 1286170003810 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1286170003811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170003812 active site 1286170003813 phosphorylation site [posttranslational modification] 1286170003814 intermolecular recognition site; other site 1286170003815 dimerization interface [polypeptide binding]; other site 1286170003816 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1286170003817 PAS domain; Region: PAS; smart00091 1286170003818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170003819 ATP binding site [chemical binding]; other site 1286170003820 Mg2+ binding site [ion binding]; other site 1286170003821 G-X-G motif; other site 1286170003822 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1286170003823 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1286170003824 putative active site [active] 1286170003825 malate:quinone oxidoreductase; Validated; Region: PRK05257 1286170003826 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1286170003827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003828 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1286170003829 putative substrate translocation pore; other site 1286170003830 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170003831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170003833 dimerization interface [polypeptide binding]; other site 1286170003834 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1286170003835 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1286170003836 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1286170003837 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1286170003838 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1286170003839 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 1286170003840 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1286170003841 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 1286170003842 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1286170003843 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1286170003844 Coenzyme A transferase; Region: CoA_trans; cl17247 1286170003845 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1286170003846 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286170003847 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1286170003848 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1286170003849 CHASE4 domain; Region: CHASE4; pfam05228 1286170003850 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170003851 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170003852 metal binding site [ion binding]; metal-binding site 1286170003853 active site 1286170003854 I-site; other site 1286170003855 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170003856 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1286170003857 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286170003858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003859 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170003860 dimerization interface [polypeptide binding]; other site 1286170003861 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286170003862 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1286170003863 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1286170003864 active site 1286170003865 Zn binding site [ion binding]; other site 1286170003866 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286170003867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003868 putative substrate translocation pore; other site 1286170003869 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1286170003870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003871 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1286170003872 dimerization interface [polypeptide binding]; other site 1286170003873 substrate binding pocket [chemical binding]; other site 1286170003874 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1286170003875 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286170003876 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286170003877 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1286170003878 AAA domain; Region: AAA_26; pfam13500 1286170003879 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1286170003880 Cl- selectivity filter; other site 1286170003881 Cl- binding residues [ion binding]; other site 1286170003882 pore gating glutamate residue; other site 1286170003883 dimer interface [polypeptide binding]; other site 1286170003884 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1286170003885 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1286170003886 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1286170003887 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1286170003888 putative [Fe4-S4] binding site [ion binding]; other site 1286170003889 putative molybdopterin cofactor binding site [chemical binding]; other site 1286170003890 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1286170003891 putative molybdopterin cofactor binding site; other site 1286170003892 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1286170003893 lipoprotein; Reviewed; Region: PRK02939 1286170003894 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1286170003895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170003896 Coenzyme A binding pocket [chemical binding]; other site 1286170003897 hypothetical protein; Provisional; Region: PRK13659 1286170003898 hypothetical protein; Provisional; Region: PRK02237 1286170003899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003900 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170003901 putative substrate translocation pore; other site 1286170003902 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1286170003903 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1286170003904 putative active site pocket [active] 1286170003905 putative metal binding site [ion binding]; other site 1286170003906 putative oxidoreductase; Provisional; Region: PRK10083 1286170003907 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1286170003908 putative NAD(P) binding site [chemical binding]; other site 1286170003909 catalytic Zn binding site [ion binding]; other site 1286170003910 structural Zn binding site [ion binding]; other site 1286170003911 metabolite-proton symporter; Region: 2A0106; TIGR00883 1286170003912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003913 putative substrate translocation pore; other site 1286170003914 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1286170003915 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1286170003916 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1286170003917 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286170003918 Ligand Binding Site [chemical binding]; other site 1286170003919 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286170003920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170003921 DNA-binding site [nucleotide binding]; DNA binding site 1286170003922 FCD domain; Region: FCD; pfam07729 1286170003923 malonic semialdehyde reductase; Provisional; Region: PRK10538 1286170003924 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1286170003925 putative NAD(P) binding site [chemical binding]; other site 1286170003926 homodimer interface [polypeptide binding]; other site 1286170003927 homotetramer interface [polypeptide binding]; other site 1286170003928 active site 1286170003929 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1286170003930 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1286170003931 active site 1286170003932 Zn binding site [ion binding]; other site 1286170003933 DinI-like family; Region: DinI; cl11630 1286170003934 beta-lactamase TEM; Provisional; Region: PRK15442 1286170003935 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1286170003936 Predicted ATPase [General function prediction only]; Region: COG4637 1286170003937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170003938 Walker A/P-loop; other site 1286170003939 ATP binding site [chemical binding]; other site 1286170003940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170003941 ABC transporter signature motif; other site 1286170003942 Walker B; other site 1286170003943 D-loop; other site 1286170003944 H-loop/switch region; other site 1286170003945 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 1286170003946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003947 putative substrate translocation pore; other site 1286170003948 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1286170003949 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1286170003950 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1286170003951 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1286170003952 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1286170003953 lac repressor; Reviewed; Region: lacI; PRK09526 1286170003954 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170003955 DNA binding site [nucleotide binding] 1286170003956 domain linker motif; other site 1286170003957 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1286170003958 ligand binding site [chemical binding]; other site 1286170003959 dimerization interface (open form) [polypeptide binding]; other site 1286170003960 dimerization interface (closed form) [polypeptide binding]; other site 1286170003961 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1286170003962 dimer interface [polypeptide binding]; other site 1286170003963 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1286170003964 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1286170003965 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1286170003966 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1286170003967 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1286170003968 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1286170003969 transcriptional regulator MirA; Provisional; Region: PRK15043 1286170003970 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1286170003971 DNA binding residues [nucleotide binding] 1286170003972 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1286170003973 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286170003974 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286170003975 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286170003976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170003977 DNA-binding site [nucleotide binding]; DNA binding site 1286170003978 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170003979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170003980 homodimer interface [polypeptide binding]; other site 1286170003981 catalytic residue [active] 1286170003982 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1286170003983 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1286170003984 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1286170003985 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286170003986 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286170003987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170003988 putative substrate translocation pore; other site 1286170003989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170003990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170003991 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286170003992 putative effector binding pocket; other site 1286170003993 putative dimerization interface [polypeptide binding]; other site 1286170003994 YdfZ protein; Region: YdfZ; cl11878 1286170003995 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1286170003996 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1286170003997 conserved cys residue [active] 1286170003998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170003999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170004000 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1286170004001 active site residue [active] 1286170004002 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1286170004003 substrate binding site [chemical binding]; other site 1286170004004 THF binding site; other site 1286170004005 zinc-binding site [ion binding]; other site 1286170004006 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1286170004007 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1286170004008 putative ligand binding site [chemical binding]; other site 1286170004009 HEAT repeats; Region: HEAT_2; pfam13646 1286170004010 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1286170004011 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170004012 TM-ABC transporter signature motif; other site 1286170004013 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1286170004014 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1286170004015 TM-ABC transporter signature motif; other site 1286170004016 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1286170004017 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1286170004018 Walker A/P-loop; other site 1286170004019 ATP binding site [chemical binding]; other site 1286170004020 Q-loop/lid; other site 1286170004021 ABC transporter signature motif; other site 1286170004022 Walker B; other site 1286170004023 D-loop; other site 1286170004024 H-loop/switch region; other site 1286170004025 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1286170004026 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1286170004027 Walker A/P-loop; other site 1286170004028 ATP binding site [chemical binding]; other site 1286170004029 Q-loop/lid; other site 1286170004030 ABC transporter signature motif; other site 1286170004031 Walker B; other site 1286170004032 D-loop; other site 1286170004033 H-loop/switch region; other site 1286170004034 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286170004035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170004036 non-specific DNA binding site [nucleotide binding]; other site 1286170004037 salt bridge; other site 1286170004038 sequence-specific DNA binding site [nucleotide binding]; other site 1286170004039 2TM domain; Region: 2TM; pfam13239 1286170004040 putative transporter; Provisional; Region: PRK10054 1286170004041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004042 putative substrate translocation pore; other site 1286170004043 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1286170004044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170004045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170004046 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170004047 putative effector binding pocket; other site 1286170004048 dimerization interface [polypeptide binding]; other site 1286170004049 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286170004050 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 1286170004051 DNA binding residues [nucleotide binding] 1286170004052 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 1286170004053 putative dimer interface [polypeptide binding]; other site 1286170004054 putative metal binding residues [ion binding]; other site 1286170004055 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 1286170004056 PQQ-like domain; Region: PQQ_2; pfam13360 1286170004057 putative outer membrane receptor; Provisional; Region: PRK13513 1286170004058 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170004059 N-terminal plug; other site 1286170004060 ligand-binding site [chemical binding]; other site 1286170004061 TolA C-terminal; Region: TolA; pfam06519 1286170004062 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1286170004063 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1286170004064 metal binding site [ion binding]; metal-binding site 1286170004065 dimer interface [polypeptide binding]; other site 1286170004066 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1286170004067 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1286170004068 active site 1286170004069 substrate binding pocket [chemical binding]; other site 1286170004070 homodimer interaction site [polypeptide binding]; other site 1286170004071 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170004072 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170004073 TM-ABC transporter signature motif; other site 1286170004074 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286170004075 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170004076 Walker A/P-loop; other site 1286170004077 ATP binding site [chemical binding]; other site 1286170004078 Q-loop/lid; other site 1286170004079 ABC transporter signature motif; other site 1286170004080 Walker B; other site 1286170004081 D-loop; other site 1286170004082 H-loop/switch region; other site 1286170004083 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170004084 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170004085 DNA binding site [nucleotide binding] 1286170004086 domain linker motif; other site 1286170004087 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 1286170004088 putative dimerization interface [polypeptide binding]; other site 1286170004089 putative ligand binding site [chemical binding]; other site 1286170004090 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286170004091 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1286170004092 ligand binding site [chemical binding]; other site 1286170004093 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170004094 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1286170004095 substrate binding site [chemical binding]; other site 1286170004096 dimer interface [polypeptide binding]; other site 1286170004097 ATP binding site [chemical binding]; other site 1286170004098 BtpA family; Region: BtpA; cl00440 1286170004099 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1286170004100 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1286170004101 RibD C-terminal domain; Region: RibD_C; cl17279 1286170004102 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1286170004103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170004104 salt bridge; other site 1286170004105 non-specific DNA binding site [nucleotide binding]; other site 1286170004106 sequence-specific DNA binding site [nucleotide binding]; other site 1286170004107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004108 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170004109 putative substrate translocation pore; other site 1286170004110 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1286170004111 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1286170004112 catalytic residues [active] 1286170004113 dimer interface [polypeptide binding]; other site 1286170004114 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170004115 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170004116 DNA binding site [nucleotide binding] 1286170004117 domain linker motif; other site 1286170004118 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1286170004119 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1286170004120 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1286170004121 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1286170004122 Cation transport protein; Region: TrkH; cl17365 1286170004123 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1286170004124 MarB protein; Region: MarB; pfam13999 1286170004125 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1286170004126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170004127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170004128 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1286170004129 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286170004130 inner membrane protein; Provisional; Region: PRK10995 1286170004131 putative arabinose transporter; Provisional; Region: PRK03545 1286170004132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004133 putative substrate translocation pore; other site 1286170004134 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1286170004135 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1286170004136 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1286170004137 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286170004138 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1286170004139 NAD binding site [chemical binding]; other site 1286170004140 dimer interface [polypeptide binding]; other site 1286170004141 substrate binding site [chemical binding]; other site 1286170004142 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286170004143 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1286170004144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170004145 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1286170004146 putative dimerization interface [polypeptide binding]; other site 1286170004147 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1286170004148 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1286170004149 NAD(P) binding site [chemical binding]; other site 1286170004150 catalytic residues [active] 1286170004151 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1286170004152 glutaminase; Provisional; Region: PRK00971 1286170004153 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1286170004154 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170004155 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170004156 metal binding site [ion binding]; metal-binding site 1286170004157 active site 1286170004158 I-site; other site 1286170004159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170004160 Coenzyme A binding pocket [chemical binding]; other site 1286170004161 altronate oxidoreductase; Provisional; Region: PRK03643 1286170004162 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1286170004163 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1286170004164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170004165 Coenzyme A binding pocket [chemical binding]; other site 1286170004166 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170004167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170004168 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170004169 putative effector binding pocket; other site 1286170004170 dimerization interface [polypeptide binding]; other site 1286170004171 PilZ domain; Region: PilZ; pfam07238 1286170004172 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1286170004173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170004174 S-adenosylmethionine binding site [chemical binding]; other site 1286170004175 major facilitator superfamily transporter; Provisional; Region: PRK05122 1286170004176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004177 putative substrate translocation pore; other site 1286170004178 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1286170004179 active site 1286170004180 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286170004181 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286170004182 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1286170004183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170004184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170004185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170004186 dimerization interface [polypeptide binding]; other site 1286170004187 Nitronate monooxygenase; Region: NMO; pfam03060 1286170004188 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1286170004189 FMN binding site [chemical binding]; other site 1286170004190 substrate binding site [chemical binding]; other site 1286170004191 putative catalytic residue [active] 1286170004192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170004193 dimer interface [polypeptide binding]; other site 1286170004194 conserved gate region; other site 1286170004195 ABC-ATPase subunit interface; other site 1286170004196 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286170004197 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1286170004198 Walker A/P-loop; other site 1286170004199 ATP binding site [chemical binding]; other site 1286170004200 Q-loop/lid; other site 1286170004201 ABC transporter signature motif; other site 1286170004202 Walker B; other site 1286170004203 D-loop; other site 1286170004204 H-loop/switch region; other site 1286170004205 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1286170004206 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1286170004207 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1286170004208 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1286170004209 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1286170004210 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1286170004211 Cupin; Region: Cupin_6; pfam12852 1286170004212 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170004213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170004214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170004215 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1286170004216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004217 putative substrate translocation pore; other site 1286170004218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286170004219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170004220 Coenzyme A binding pocket [chemical binding]; other site 1286170004221 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1286170004222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004223 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1286170004224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004225 putative substrate translocation pore; other site 1286170004226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004227 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286170004228 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286170004229 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1286170004230 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1286170004231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170004232 dimer interface [polypeptide binding]; other site 1286170004233 phosphorylation site [posttranslational modification] 1286170004234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170004235 ATP binding site [chemical binding]; other site 1286170004236 Mg2+ binding site [ion binding]; other site 1286170004237 G-X-G motif; other site 1286170004238 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1286170004239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170004240 active site 1286170004241 phosphorylation site [posttranslational modification] 1286170004242 intermolecular recognition site; other site 1286170004243 dimerization interface [polypeptide binding]; other site 1286170004244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1286170004245 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286170004246 Tetratricopeptide repeat; Region: TPR_15; pfam13429 1286170004247 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1286170004248 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1286170004249 active site 1286170004250 substrate binding site [chemical binding]; other site 1286170004251 Mg2+ binding site [ion binding]; other site 1286170004252 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1286170004253 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1286170004254 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1286170004255 active site 1286170004256 substrate binding site [chemical binding]; other site 1286170004257 trimer interface [polypeptide binding]; other site 1286170004258 CoA binding site [chemical binding]; other site 1286170004259 SnoaL-like domain; Region: SnoaL_4; pfam13577 1286170004260 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1286170004261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170004262 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1286170004263 dimerization interface [polypeptide binding]; other site 1286170004264 substrate binding pocket [chemical binding]; other site 1286170004265 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286170004266 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286170004267 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286170004268 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1286170004269 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286170004270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170004271 DNA-binding site [nucleotide binding]; DNA binding site 1286170004272 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170004273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170004274 homodimer interface [polypeptide binding]; other site 1286170004275 catalytic residue [active] 1286170004276 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286170004277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170004278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286170004279 Coenzyme A binding pocket [chemical binding]; other site 1286170004280 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1286170004281 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1286170004282 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1286170004283 K+ potassium transporter; Region: K_trans; pfam02705 1286170004284 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 1286170004285 active site 1286170004286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1286170004287 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286170004288 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1286170004289 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1286170004290 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1286170004291 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1286170004292 Walker A/P-loop; other site 1286170004293 ATP binding site [chemical binding]; other site 1286170004294 Q-loop/lid; other site 1286170004295 ABC transporter signature motif; other site 1286170004296 Walker B; other site 1286170004297 D-loop; other site 1286170004298 H-loop/switch region; other site 1286170004299 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1286170004300 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1286170004301 Walker A/P-loop; other site 1286170004302 ATP binding site [chemical binding]; other site 1286170004303 Q-loop/lid; other site 1286170004304 ABC transporter signature motif; other site 1286170004305 Walker B; other site 1286170004306 D-loop; other site 1286170004307 H-loop/switch region; other site 1286170004308 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1286170004309 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1286170004310 TM-ABC transporter signature motif; other site 1286170004311 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170004312 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1286170004313 TM-ABC transporter signature motif; other site 1286170004314 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1286170004315 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1286170004316 dimerization interface [polypeptide binding]; other site 1286170004317 ligand binding site [chemical binding]; other site 1286170004318 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1286170004319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1286170004320 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1286170004321 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1286170004322 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1286170004323 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1286170004324 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286170004325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170004326 non-specific DNA binding site [nucleotide binding]; other site 1286170004327 salt bridge; other site 1286170004328 sequence-specific DNA binding site [nucleotide binding]; other site 1286170004329 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1286170004330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286170004331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286170004332 DNA binding residues [nucleotide binding] 1286170004333 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286170004334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170004335 S-adenosylmethionine binding site [chemical binding]; other site 1286170004336 PAS domain S-box; Region: sensory_box; TIGR00229 1286170004337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286170004338 putative active site [active] 1286170004339 heme pocket [chemical binding]; other site 1286170004340 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170004341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170004342 metal binding site [ion binding]; metal-binding site 1286170004343 active site 1286170004344 I-site; other site 1286170004345 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 1286170004346 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1286170004347 Surface antigen; Region: Bac_surface_Ag; pfam01103 1286170004348 Putative transcription activator [Transcription]; Region: TenA; COG0819 1286170004349 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286170004350 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286170004351 Walker A/P-loop; other site 1286170004352 ATP binding site [chemical binding]; other site 1286170004353 Q-loop/lid; other site 1286170004354 ABC transporter signature motif; other site 1286170004355 Walker B; other site 1286170004356 D-loop; other site 1286170004357 H-loop/switch region; other site 1286170004358 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286170004359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170004360 dimer interface [polypeptide binding]; other site 1286170004361 conserved gate region; other site 1286170004362 ABC-ATPase subunit interface; other site 1286170004363 NMT1/THI5 like; Region: NMT1; pfam09084 1286170004364 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1286170004365 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 1286170004366 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286170004367 inhibitor-cofactor binding pocket; inhibition site 1286170004368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170004369 catalytic residue [active] 1286170004370 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1286170004371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170004372 catalytic residue [active] 1286170004373 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1286170004374 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1286170004375 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1286170004376 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286170004377 catalytic residues [active] 1286170004378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286170004379 HAMP domain; Region: HAMP; pfam00672 1286170004380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170004381 dimer interface [polypeptide binding]; other site 1286170004382 phosphorylation site [posttranslational modification] 1286170004383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170004384 ATP binding site [chemical binding]; other site 1286170004385 Mg2+ binding site [ion binding]; other site 1286170004386 G-X-G motif; other site 1286170004387 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1286170004388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170004389 active site 1286170004390 phosphorylation site [posttranslational modification] 1286170004391 intermolecular recognition site; other site 1286170004392 dimerization interface [polypeptide binding]; other site 1286170004393 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170004394 DNA binding site [nucleotide binding] 1286170004395 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286170004396 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1286170004397 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1286170004398 catalytic triad [active] 1286170004399 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1286170004400 Class I aldolases; Region: Aldolase_Class_I; cl17187 1286170004401 catalytic residue [active] 1286170004402 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286170004403 FAD binding domain; Region: FAD_binding_4; pfam01565 1286170004404 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286170004405 L-fuculokinase; Region: fuculo_kin_coli; TIGR02628 1286170004406 nucleotide binding site [chemical binding]; other site 1286170004407 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1286170004408 putative substrate binding site [chemical binding]; other site 1286170004409 putative ATP binding site [chemical binding]; other site 1286170004410 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1286170004411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004412 putative substrate translocation pore; other site 1286170004413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004414 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1286170004415 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1286170004416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004417 putative substrate translocation pore; other site 1286170004418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004419 penicillin-binding protein 2; Provisional; Region: PRK10795 1286170004420 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286170004421 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286170004422 allophanate hydrolase; Provisional; Region: PRK08186 1286170004423 Amidase; Region: Amidase; cl11426 1286170004424 urea carboxylase; Region: urea_carbox; TIGR02712 1286170004425 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286170004426 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1286170004427 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1286170004428 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1286170004429 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1286170004430 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1286170004431 carboxyltransferase (CT) interaction site; other site 1286170004432 biotinylation site [posttranslational modification]; other site 1286170004433 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1286170004434 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1286170004435 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1286170004436 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1286170004437 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286170004438 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1286170004439 Walker A/P-loop; other site 1286170004440 ATP binding site [chemical binding]; other site 1286170004441 Q-loop/lid; other site 1286170004442 ABC transporter signature motif; other site 1286170004443 Walker B; other site 1286170004444 D-loop; other site 1286170004445 H-loop/switch region; other site 1286170004446 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286170004447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170004448 dimer interface [polypeptide binding]; other site 1286170004449 conserved gate region; other site 1286170004450 ABC-ATPase subunit interface; other site 1286170004451 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1286170004452 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1286170004453 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1286170004454 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1286170004455 heme binding site [chemical binding]; other site 1286170004456 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1286170004457 Predicted ATPase [General function prediction only]; Region: COG1485 1286170004458 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1286170004459 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170004460 N-terminal plug; other site 1286170004461 ligand-binding site [chemical binding]; other site 1286170004462 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1286170004463 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1286170004464 intersubunit interface [polypeptide binding]; other site 1286170004465 benzoate transport; Region: 2A0115; TIGR00895 1286170004466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004467 putative substrate translocation pore; other site 1286170004468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004469 putative substrate translocation pore; other site 1286170004470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170004471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170004472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286170004473 dimerization interface [polypeptide binding]; other site 1286170004474 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286170004475 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170004476 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170004477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170004478 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286170004479 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1286170004480 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1286170004481 putative molybdopterin cofactor binding site [chemical binding]; other site 1286170004482 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1286170004483 putative molybdopterin cofactor binding site; other site 1286170004484 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1286170004485 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1286170004486 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1286170004487 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1286170004488 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 1286170004489 tetramer interface [polypeptide binding]; other site 1286170004490 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 1286170004491 tetramer interface [polypeptide binding]; other site 1286170004492 active site 1286170004493 metal binding site [ion binding]; metal-binding site 1286170004494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004495 putative substrate translocation pore; other site 1286170004496 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170004497 hypothetical protein; Provisional; Region: PRK07538 1286170004498 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286170004499 Amidohydrolase; Region: Amidohydro_2; pfam04909 1286170004500 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286170004501 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1286170004502 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 1286170004503 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286170004504 homotrimer interaction site [polypeptide binding]; other site 1286170004505 putative active site [active] 1286170004506 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1286170004507 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1286170004508 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1286170004509 SnoaL-like domain; Region: SnoaL_3; pfam13474 1286170004510 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1286170004511 short chain dehydrogenase; Provisional; Region: PRK08339 1286170004512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170004513 NAD(P) binding site [chemical binding]; other site 1286170004514 active site 1286170004515 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170004516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170004517 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170004518 putative effector binding pocket; other site 1286170004519 dimerization interface [polypeptide binding]; other site 1286170004520 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1286170004521 30S ribosomal protein subunit S22 family; Region: Ribosomal_S22; cl11579 1286170004522 malate dehydrogenase; Provisional; Region: PRK13529 1286170004523 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1286170004524 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1286170004525 NAD(P) binding site [chemical binding]; other site 1286170004526 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286170004527 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170004528 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170004529 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286170004530 MarR family; Region: MarR_2; pfam12802 1286170004531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170004532 Coenzyme A binding pocket [chemical binding]; other site 1286170004533 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1286170004534 dimer interface [polypeptide binding]; other site 1286170004535 substrate binding site [chemical binding]; other site 1286170004536 metal binding sites [ion binding]; metal-binding site 1286170004537 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1286170004538 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1286170004539 NAD binding site [chemical binding]; other site 1286170004540 substrate binding site [chemical binding]; other site 1286170004541 catalytic Zn binding site [ion binding]; other site 1286170004542 tetramer interface [polypeptide binding]; other site 1286170004543 structural Zn binding site [ion binding]; other site 1286170004544 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286170004545 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1286170004546 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286170004547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170004548 dimer interface [polypeptide binding]; other site 1286170004549 conserved gate region; other site 1286170004550 ABC-ATPase subunit interface; other site 1286170004551 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286170004552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170004553 ABC-ATPase subunit interface; other site 1286170004554 putative PBP binding loops; other site 1286170004555 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286170004556 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170004557 Walker A/P-loop; other site 1286170004558 ATP binding site [chemical binding]; other site 1286170004559 Q-loop/lid; other site 1286170004560 ABC transporter signature motif; other site 1286170004561 Walker B; other site 1286170004562 D-loop; other site 1286170004563 H-loop/switch region; other site 1286170004564 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286170004565 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170004566 Walker A/P-loop; other site 1286170004567 ATP binding site [chemical binding]; other site 1286170004568 Q-loop/lid; other site 1286170004569 ABC transporter signature motif; other site 1286170004570 Walker B; other site 1286170004571 D-loop; other site 1286170004572 H-loop/switch region; other site 1286170004573 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286170004574 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 1286170004575 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1286170004576 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 1286170004577 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 1286170004578 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1286170004579 MFS transport protein AraJ; Provisional; Region: PRK10091 1286170004580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004581 putative substrate translocation pore; other site 1286170004582 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1286170004583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286170004584 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1286170004585 active site 1286170004586 metal binding site [ion binding]; metal-binding site 1286170004587 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1286170004588 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1286170004589 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1286170004590 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1286170004591 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170004592 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170004593 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1286170004594 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1286170004595 molybdopterin cofactor binding site; other site 1286170004596 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170004597 aromatic amino acid exporter; Provisional; Region: PRK11689 1286170004598 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1286170004599 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1286170004600 putative NAD(P) binding site [chemical binding]; other site 1286170004601 active site 1286170004602 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1286170004603 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286170004604 catalytic loop [active] 1286170004605 iron binding site [ion binding]; other site 1286170004606 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1286170004607 FAD binding pocket [chemical binding]; other site 1286170004608 FAD binding motif [chemical binding]; other site 1286170004609 phosphate binding motif [ion binding]; other site 1286170004610 beta-alpha-beta structure motif; other site 1286170004611 NAD binding pocket [chemical binding]; other site 1286170004612 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1286170004613 inter-subunit interface; other site 1286170004614 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1286170004615 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1286170004616 iron-sulfur cluster [ion binding]; other site 1286170004617 [2Fe-2S] cluster binding site [ion binding]; other site 1286170004618 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1286170004619 putative alpha subunit interface [polypeptide binding]; other site 1286170004620 putative active site [active] 1286170004621 putative substrate binding site [chemical binding]; other site 1286170004622 Fe binding site [ion binding]; other site 1286170004623 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1286170004624 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 1286170004625 dimer interface [polypeptide binding]; other site 1286170004626 active site 1286170004627 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1286170004628 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1286170004629 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1286170004630 octamer interface [polypeptide binding]; other site 1286170004631 active site 1286170004632 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1286170004633 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286170004634 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286170004635 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1286170004636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004637 putative substrate translocation pore; other site 1286170004638 TetR family transcriptional regulator; Provisional; Region: PRK14996 1286170004639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170004640 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1286170004641 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1286170004642 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1286170004643 [4Fe-4S] binding site [ion binding]; other site 1286170004644 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170004645 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170004646 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170004647 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1286170004648 molybdopterin cofactor binding site; other site 1286170004649 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1286170004650 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1286170004651 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1286170004652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170004653 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170004654 dimerization interface [polypeptide binding]; other site 1286170004655 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1286170004656 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1286170004657 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286170004658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170004659 dimer interface [polypeptide binding]; other site 1286170004660 conserved gate region; other site 1286170004661 putative PBP binding loops; other site 1286170004662 ABC-ATPase subunit interface; other site 1286170004663 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286170004664 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286170004665 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1286170004666 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286170004667 Walker A/P-loop; other site 1286170004668 ATP binding site [chemical binding]; other site 1286170004669 Q-loop/lid; other site 1286170004670 ABC transporter signature motif; other site 1286170004671 Walker B; other site 1286170004672 D-loop; other site 1286170004673 H-loop/switch region; other site 1286170004674 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1286170004675 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286170004676 MarR family; Region: MarR_2; cl17246 1286170004677 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1286170004678 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1286170004679 transcriptional activator RhaR; Provisional; Region: PRK13501 1286170004680 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286170004681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170004682 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1286170004683 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1286170004684 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1286170004685 potential frameshift: common BLAST hit: gi|397657870|ref|YP_006498572.1| maltoporin 1286170004686 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 1286170004687 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1286170004688 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286170004689 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1286170004690 dimer interface [polypeptide binding]; other site 1286170004691 N-terminal domain interface [polypeptide binding]; other site 1286170004692 substrate binding pocket (H-site) [chemical binding]; other site 1286170004693 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170004694 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170004695 substrate binding pocket [chemical binding]; other site 1286170004696 membrane-bound complex binding site; other site 1286170004697 hinge residues; other site 1286170004698 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286170004699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170004700 Walker A/P-loop; other site 1286170004701 ATP binding site [chemical binding]; other site 1286170004702 Q-loop/lid; other site 1286170004703 ABC transporter signature motif; other site 1286170004704 Walker B; other site 1286170004705 D-loop; other site 1286170004706 H-loop/switch region; other site 1286170004707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170004708 dimer interface [polypeptide binding]; other site 1286170004709 conserved gate region; other site 1286170004710 putative PBP binding loops; other site 1286170004711 ABC-ATPase subunit interface; other site 1286170004712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170004713 Coenzyme A binding pocket [chemical binding]; other site 1286170004714 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170004715 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170004716 substrate binding pocket [chemical binding]; other site 1286170004717 membrane-bound complex binding site; other site 1286170004718 hinge residues; other site 1286170004719 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1286170004720 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1286170004721 active site 1286170004722 non-prolyl cis peptide bond; other site 1286170004723 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286170004724 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1286170004725 metal binding site [ion binding]; metal-binding site 1286170004726 dimer interface [polypeptide binding]; other site 1286170004727 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1286170004728 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1286170004729 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1286170004730 AAA domain; Region: AAA_17; pfam13207 1286170004731 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1286170004732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170004733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170004734 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286170004735 putative effector binding pocket; other site 1286170004736 putative dimerization interface [polypeptide binding]; other site 1286170004737 L-asparagine permease; Provisional; Region: PRK15049 1286170004738 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1286170004739 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1286170004740 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1286170004741 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1286170004742 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170004743 N-terminal plug; other site 1286170004744 ligand-binding site [chemical binding]; other site 1286170004745 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1286170004746 active site 1286170004747 tetramer interface [polypeptide binding]; other site 1286170004748 Protein of unknown function, DUF596; Region: DUF596; pfam04591 1286170004749 Protein of unknown function, DUF596; Region: DUF596; cl10492 1286170004750 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1286170004751 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1286170004752 NAD(P) binding site [chemical binding]; other site 1286170004753 substrate binding site [chemical binding]; other site 1286170004754 dimer interface [polypeptide binding]; other site 1286170004755 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286170004756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170004757 sequence-specific DNA binding site [nucleotide binding]; other site 1286170004758 salt bridge; other site 1286170004759 Cupin domain; Region: Cupin_2; cl17218 1286170004760 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1286170004761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170004762 Coenzyme A binding pocket [chemical binding]; other site 1286170004763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1286170004764 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1286170004765 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286170004766 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1286170004767 peptide binding site [polypeptide binding]; other site 1286170004768 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286170004769 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 1286170004770 NAD(P) binding site [chemical binding]; other site 1286170004771 catalytic residues [active] 1286170004772 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286170004773 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1286170004774 GnsA/GnsB family; Region: GnsAB; pfam08178 1286170004775 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1286170004776 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1286170004777 tetrameric interface [polypeptide binding]; other site 1286170004778 NAD binding site [chemical binding]; other site 1286170004779 catalytic residues [active] 1286170004780 substrate binding site [chemical binding]; other site 1286170004781 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286170004782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286170004783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170004784 putative PBP binding loops; other site 1286170004785 dimer interface [polypeptide binding]; other site 1286170004786 ABC-ATPase subunit interface; other site 1286170004787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170004788 dimer interface [polypeptide binding]; other site 1286170004789 conserved gate region; other site 1286170004790 putative PBP binding loops; other site 1286170004791 ABC-ATPase subunit interface; other site 1286170004792 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286170004793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170004794 Walker A/P-loop; other site 1286170004795 ATP binding site [chemical binding]; other site 1286170004796 Q-loop/lid; other site 1286170004797 ABC transporter signature motif; other site 1286170004798 Walker B; other site 1286170004799 D-loop; other site 1286170004800 H-loop/switch region; other site 1286170004801 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286170004802 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286170004803 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286170004804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170004805 DNA-binding site [nucleotide binding]; DNA binding site 1286170004806 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170004807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170004808 homodimer interface [polypeptide binding]; other site 1286170004809 catalytic residue [active] 1286170004810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004811 putative substrate translocation pore; other site 1286170004812 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286170004813 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1286170004814 nucleotide binding site [chemical binding]; other site 1286170004815 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1286170004816 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170004817 FAD binding domain; Region: FAD_binding_4; pfam01565 1286170004818 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1286170004819 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1286170004820 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1286170004821 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1286170004822 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1286170004823 putative active site [active] 1286170004824 metal binding site [ion binding]; metal-binding site 1286170004825 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1286170004826 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1286170004827 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1286170004828 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1286170004829 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1286170004830 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1286170004831 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1286170004832 Peptidase family U32; Region: Peptidase_U32; pfam01136 1286170004833 Collagenase; Region: DUF3656; pfam12392 1286170004834 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286170004835 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170004836 non-specific DNA binding site [nucleotide binding]; other site 1286170004837 salt bridge; other site 1286170004838 sequence-specific DNA binding site [nucleotide binding]; other site 1286170004839 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1286170004840 benzoate transporter; Region: benE; TIGR00843 1286170004841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170004842 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170004843 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170004844 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286170004845 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1286170004846 EamA-like transporter family; Region: EamA; pfam00892 1286170004847 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1286170004848 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286170004849 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1286170004850 peptide binding site [polypeptide binding]; other site 1286170004851 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1286170004852 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1286170004853 metal binding site [ion binding]; metal-binding site 1286170004854 dimer interface [polypeptide binding]; other site 1286170004855 tellurite resistance protein TehB; Provisional; Region: PRK11207 1286170004856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170004857 S-adenosylmethionine binding site [chemical binding]; other site 1286170004858 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1286170004859 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1286170004860 gating phenylalanine in ion channel; other site 1286170004861 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1286170004862 putative trimer interface [polypeptide binding]; other site 1286170004863 putative CoA binding site [chemical binding]; other site 1286170004864 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1286170004865 putative trimer interface [polypeptide binding]; other site 1286170004866 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1286170004867 putative trimer interface [polypeptide binding]; other site 1286170004868 putative CoA binding site [chemical binding]; other site 1286170004869 putative CoA binding site [chemical binding]; other site 1286170004870 ribosomal-protein-L7/L12-serine acetyltransferase; Provisional; Region: PRK10151 1286170004871 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286170004872 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1286170004873 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1286170004874 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1286170004875 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170004876 substrate binding pocket [chemical binding]; other site 1286170004877 membrane-bound complex binding site; other site 1286170004878 hinge residues; other site 1286170004879 putative aminotransferase; Provisional; Region: PRK12414 1286170004880 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170004881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170004882 homodimer interface [polypeptide binding]; other site 1286170004883 catalytic residue [active] 1286170004884 Isochorismatase family; Region: Isochorismatase; pfam00857 1286170004885 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1286170004886 catalytic triad [active] 1286170004887 dimer interface [polypeptide binding]; other site 1286170004888 conserved cis-peptide bond; other site 1286170004889 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286170004890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170004891 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170004892 dimerization interface [polypeptide binding]; other site 1286170004893 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1286170004894 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1286170004895 substrate binding pocket [chemical binding]; other site 1286170004896 catalytic triad [active] 1286170004897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1286170004898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1286170004899 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1286170004900 heterodimer interface [polypeptide binding]; other site 1286170004901 multimer interface [polypeptide binding]; other site 1286170004902 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1286170004903 active site 1286170004904 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1286170004905 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1286170004906 heterodimer interface [polypeptide binding]; other site 1286170004907 active site 1286170004908 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1286170004909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170004910 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1286170004911 putative dimerization interface [polypeptide binding]; other site 1286170004912 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1286170004913 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1286170004914 Trp docking motif [polypeptide binding]; other site 1286170004915 putative active site [active] 1286170004916 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1286170004917 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1286170004918 substrate binding site [chemical binding]; other site 1286170004919 catalytic Zn binding site [ion binding]; other site 1286170004920 NAD binding site [chemical binding]; other site 1286170004921 structural Zn binding site [ion binding]; other site 1286170004922 dimer interface [polypeptide binding]; other site 1286170004923 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1286170004924 putative metal binding site [ion binding]; other site 1286170004925 putative homodimer interface [polypeptide binding]; other site 1286170004926 putative homotetramer interface [polypeptide binding]; other site 1286170004927 putative homodimer-homodimer interface [polypeptide binding]; other site 1286170004928 putative allosteric switch controlling residues; other site 1286170004929 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286170004930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170004931 Coenzyme A binding pocket [chemical binding]; other site 1286170004932 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1286170004933 Putative glucoamylase; Region: Glycoamylase; pfam10091 1286170004934 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1286170004935 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1286170004936 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1286170004937 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1286170004938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170004939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170004940 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170004941 putative effector binding pocket; other site 1286170004942 dimerization interface [polypeptide binding]; other site 1286170004943 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1286170004944 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1286170004945 NAD(P) binding site [chemical binding]; other site 1286170004946 active site 1286170004947 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1286170004948 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1286170004949 Cation efflux family; Region: Cation_efflux; pfam01545 1286170004950 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 1286170004951 putative active site [active] 1286170004952 Zn binding site [ion binding]; other site 1286170004953 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 1286170004954 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286170004955 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170004956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170004957 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1286170004958 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1286170004959 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1286170004960 putative active site pocket [active] 1286170004961 dimerization interface [polypeptide binding]; other site 1286170004962 putative catalytic residue [active] 1286170004963 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1286170004964 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1286170004965 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1286170004966 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1286170004967 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286170004968 NAD binding site [chemical binding]; other site 1286170004969 catalytic residues [active] 1286170004970 substrate binding site [chemical binding]; other site 1286170004971 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1286170004972 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1286170004973 putative active site [active] 1286170004974 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1286170004975 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1286170004976 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1286170004977 active site 1286170004978 Zn binding site [ion binding]; other site 1286170004979 succinylarginine dihydrolase; Provisional; Region: PRK13281 1286170004980 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1286170004981 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1286170004982 NAD(P) binding site [chemical binding]; other site 1286170004983 catalytic residues [active] 1286170004984 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1286170004985 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 1286170004986 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1286170004987 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286170004988 inhibitor-cofactor binding pocket; inhibition site 1286170004989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170004990 catalytic residue [active] 1286170004991 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1286170004992 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1286170004993 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1286170004994 NAD(P) binding site [chemical binding]; other site 1286170004995 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286170004996 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1286170004997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170004998 putative substrate translocation pore; other site 1286170004999 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1286170005000 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170005001 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170005002 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1286170005003 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1286170005004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170005005 S-adenosylmethionine binding site [chemical binding]; other site 1286170005006 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1286170005007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286170005008 ATP binding site [chemical binding]; other site 1286170005009 putative Mg++ binding site [ion binding]; other site 1286170005010 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170005011 nucleotide binding region [chemical binding]; other site 1286170005012 ATP-binding site [chemical binding]; other site 1286170005013 Helicase associated domain (HA2); Region: HA2; pfam04408 1286170005014 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1286170005015 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1286170005016 azoreductase; Reviewed; Region: PRK00170 1286170005017 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286170005018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170005019 non-specific DNA binding site [nucleotide binding]; other site 1286170005020 salt bridge; other site 1286170005021 sequence-specific DNA binding site [nucleotide binding]; other site 1286170005022 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 1286170005023 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1286170005024 putative trimer interface [polypeptide binding]; other site 1286170005025 putative metal binding site [ion binding]; other site 1286170005026 PaaX-like protein; Region: PaaX; pfam07848 1286170005027 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1286170005028 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1286170005029 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1286170005030 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1286170005031 active site 1286170005032 AMP binding site [chemical binding]; other site 1286170005033 homodimer interface [polypeptide binding]; other site 1286170005034 acyl-activating enzyme (AAE) consensus motif; other site 1286170005035 CoA binding site [chemical binding]; other site 1286170005036 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1286170005037 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286170005038 dimer interface [polypeptide binding]; other site 1286170005039 active site 1286170005040 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1286170005041 CoenzymeA binding site [chemical binding]; other site 1286170005042 subunit interaction site [polypeptide binding]; other site 1286170005043 PHB binding site; other site 1286170005044 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1286170005045 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1286170005046 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286170005047 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286170005048 enoyl-CoA hydratase; Provisional; Region: PRK08140 1286170005049 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286170005050 substrate binding site [chemical binding]; other site 1286170005051 oxyanion hole (OAH) forming residues; other site 1286170005052 trimer interface [polypeptide binding]; other site 1286170005053 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 1286170005054 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286170005055 substrate binding site [chemical binding]; other site 1286170005056 oxyanion hole (OAH) forming residues; other site 1286170005057 trimer interface [polypeptide binding]; other site 1286170005058 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1286170005059 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1286170005060 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1286170005061 FAD binding pocket [chemical binding]; other site 1286170005062 FAD binding motif [chemical binding]; other site 1286170005063 phosphate binding motif [ion binding]; other site 1286170005064 beta-alpha-beta structure motif; other site 1286170005065 NAD(p) ribose binding residues [chemical binding]; other site 1286170005066 NAD binding pocket [chemical binding]; other site 1286170005067 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1286170005068 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286170005069 catalytic loop [active] 1286170005070 iron binding site [ion binding]; other site 1286170005071 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1286170005072 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1286170005073 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1286170005074 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1286170005075 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1286170005076 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1286170005077 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1286170005078 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1286170005079 substrate binding site [chemical binding]; other site 1286170005080 dimer interface [polypeptide binding]; other site 1286170005081 NADP binding site [chemical binding]; other site 1286170005082 catalytic residues [active] 1286170005083 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 1286170005084 substrate binding site [chemical binding]; other site 1286170005085 tyramine oxidase; Provisional; Region: tynA; PRK14696 1286170005086 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1286170005087 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1286170005088 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1286170005089 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1286170005090 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1286170005091 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286170005092 NADP binding site [chemical binding]; other site 1286170005093 dimer interface [polypeptide binding]; other site 1286170005094 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1286170005095 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1286170005096 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1286170005097 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 1286170005098 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1286170005099 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286170005100 NAD(P) binding site [chemical binding]; other site 1286170005101 catalytic residues [active] 1286170005102 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1286170005103 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170005104 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1286170005105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170005106 putative substrate translocation pore; other site 1286170005107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170005108 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286170005109 active site 1286170005110 phosphorylation site [posttranslational modification] 1286170005111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1286170005112 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1286170005113 hypothetical protein; Provisional; Region: PRK10695 1286170005114 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286170005115 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1286170005116 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1286170005117 putative ligand binding site [chemical binding]; other site 1286170005118 putative NAD binding site [chemical binding]; other site 1286170005119 catalytic site [active] 1286170005120 META domain; Region: META; cl01245 1286170005121 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1286170005122 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1286170005123 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1286170005124 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1286170005125 dimer interface [polypeptide binding]; other site 1286170005126 PYR/PP interface [polypeptide binding]; other site 1286170005127 TPP binding site [chemical binding]; other site 1286170005128 substrate binding site [chemical binding]; other site 1286170005129 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1286170005130 Domain of unknown function; Region: EKR; pfam10371 1286170005131 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1286170005132 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286170005133 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1286170005134 TPP-binding site [chemical binding]; other site 1286170005135 dimer interface [polypeptide binding]; other site 1286170005136 KTSC domain; Region: KTSC; pfam13619 1286170005137 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286170005138 Ligand Binding Site [chemical binding]; other site 1286170005139 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1286170005140 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1286170005141 Ligand Binding Site [chemical binding]; other site 1286170005142 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1286170005143 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1286170005144 ATP binding site [chemical binding]; other site 1286170005145 Mg++ binding site [ion binding]; other site 1286170005146 motif III; other site 1286170005147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170005148 nucleotide binding region [chemical binding]; other site 1286170005149 ATP-binding site [chemical binding]; other site 1286170005150 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1286170005151 putative RNA binding site [nucleotide binding]; other site 1286170005152 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1286170005153 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1286170005154 Cl binding site [ion binding]; other site 1286170005155 oligomer interface [polypeptide binding]; other site 1286170005156 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286170005157 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1286170005158 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286170005159 putative oxidoreductase; Provisional; Region: PRK11579 1286170005160 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286170005161 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286170005162 Predicted transcriptional regulator [Transcription]; Region: COG2378 1286170005163 HTH domain; Region: HTH_11; pfam08279 1286170005164 WYL domain; Region: WYL; pfam13280 1286170005165 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286170005166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170005167 NAD(P) binding site [chemical binding]; other site 1286170005168 active site 1286170005169 short chain dehydrogenase; Provisional; Region: PRK06180 1286170005170 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1286170005171 NADP binding site [chemical binding]; other site 1286170005172 active site 1286170005173 steroid binding site; other site 1286170005174 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1286170005175 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170005176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170005177 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286170005178 homotrimer interaction site [polypeptide binding]; other site 1286170005179 putative active site [active] 1286170005180 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1286170005181 Predicted membrane protein [Function unknown]; Region: COG2323 1286170005182 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286170005183 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1286170005184 short chain dehydrogenase; Provisional; Region: PRK07041 1286170005185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170005186 NAD(P) binding site [chemical binding]; other site 1286170005187 active site 1286170005188 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1286170005189 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1286170005190 FMN binding site [chemical binding]; other site 1286170005191 active site 1286170005192 substrate binding site [chemical binding]; other site 1286170005193 catalytic residue [active] 1286170005194 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170005195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170005196 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170005197 putative effector binding pocket; other site 1286170005198 dimerization interface [polypeptide binding]; other site 1286170005199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170005200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170005201 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170005202 putative effector binding pocket; other site 1286170005203 dimerization interface [polypeptide binding]; other site 1286170005204 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286170005205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170005206 putative substrate translocation pore; other site 1286170005207 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286170005208 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286170005209 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1286170005210 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170005211 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170005212 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1286170005213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170005214 putative substrate translocation pore; other site 1286170005215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170005216 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 1286170005217 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1286170005218 dimer interface [polypeptide binding]; other site 1286170005219 active site 1286170005220 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1286170005221 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170005222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170005223 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170005224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170005225 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1286170005226 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1286170005227 putative NAD(P) binding site [chemical binding]; other site 1286170005228 putative substrate binding site [chemical binding]; other site 1286170005229 catalytic Zn binding site [ion binding]; other site 1286170005230 structural Zn binding site [ion binding]; other site 1286170005231 dimer interface [polypeptide binding]; other site 1286170005232 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286170005233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170005234 DNA-binding site [nucleotide binding]; DNA binding site 1286170005235 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170005236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170005237 homodimer interface [polypeptide binding]; other site 1286170005238 catalytic residue [active] 1286170005239 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1286170005240 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286170005241 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1286170005242 homodimer interaction site [polypeptide binding]; other site 1286170005243 cofactor binding site; other site 1286170005244 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1286170005245 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170005246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170005247 putative substrate translocation pore; other site 1286170005248 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1286170005249 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1286170005250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170005251 active site 1286170005252 phosphorylation site [posttranslational modification] 1286170005253 intermolecular recognition site; other site 1286170005254 dimerization interface [polypeptide binding]; other site 1286170005255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170005256 DNA binding site [nucleotide binding] 1286170005257 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1286170005258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170005259 dimer interface [polypeptide binding]; other site 1286170005260 phosphorylation site [posttranslational modification] 1286170005261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170005262 ATP binding site [chemical binding]; other site 1286170005263 Mg2+ binding site [ion binding]; other site 1286170005264 G-X-G motif; other site 1286170005265 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1286170005266 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 1286170005267 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1286170005268 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1286170005269 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1286170005270 potential frameshift: common BLAST hit: gi|375257260|ref|YP_005016430.1| flavodoxin 1286170005271 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 1286170005272 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286170005273 catalytic site [active] 1286170005274 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1286170005275 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1286170005276 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170005277 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170005278 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1286170005279 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1286170005280 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170005281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170005282 RibD C-terminal domain; Region: RibD_C; cl17279 1286170005283 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1286170005284 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1286170005285 short chain dehydrogenase; Provisional; Region: PRK06198 1286170005286 classical (c) SDRs; Region: SDR_c; cd05233 1286170005287 NAD(P) binding site [chemical binding]; other site 1286170005288 active site 1286170005289 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170005290 DNA binding site [nucleotide binding] 1286170005291 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1286170005292 putative ligand binding site [chemical binding]; other site 1286170005293 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286170005294 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1286170005295 dimer interface [polypeptide binding]; other site 1286170005296 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286170005297 ligand binding site [chemical binding]; other site 1286170005298 short chain dehydrogenase; Provisional; Region: PRK06500 1286170005299 classical (c) SDRs; Region: SDR_c; cd05233 1286170005300 NAD(P) binding site [chemical binding]; other site 1286170005301 active site 1286170005302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170005303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170005304 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1286170005305 putative effector binding pocket; other site 1286170005306 putative dimerization interface [polypeptide binding]; other site 1286170005307 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286170005308 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286170005309 inhibitor site; inhibition site 1286170005310 active site 1286170005311 dimer interface [polypeptide binding]; other site 1286170005312 catalytic residue [active] 1286170005313 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1286170005314 B3/4 domain; Region: B3_4; pfam03483 1286170005315 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1286170005316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170005317 non-specific DNA binding site [nucleotide binding]; other site 1286170005318 salt bridge; other site 1286170005319 sequence-specific DNA binding site [nucleotide binding]; other site 1286170005320 Cupin domain; Region: Cupin_2; pfam07883 1286170005321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170005322 Coenzyme A binding pocket [chemical binding]; other site 1286170005323 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170005324 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170005325 active site 1286170005326 catalytic tetrad [active] 1286170005327 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170005328 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170005329 active site 1286170005330 catalytic tetrad [active] 1286170005331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170005332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170005333 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286170005334 putative effector binding pocket; other site 1286170005335 putative dimerization interface [polypeptide binding]; other site 1286170005336 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1286170005337 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1286170005338 NAD(P) binding site [chemical binding]; other site 1286170005339 putative active site [active] 1286170005340 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1286170005341 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1286170005342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170005343 short chain dehydrogenase; Validated; Region: PRK06182 1286170005344 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1286170005345 NADP binding site [chemical binding]; other site 1286170005346 active site 1286170005347 steroid binding site; other site 1286170005348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170005349 NAD(P) binding site [chemical binding]; other site 1286170005350 active site 1286170005351 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170005352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170005353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170005354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170005355 dimerization interface [polypeptide binding]; other site 1286170005356 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1286170005357 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1286170005358 potential catalytic triad [active] 1286170005359 conserved cys residue [active] 1286170005360 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1286170005361 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1286170005362 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1286170005363 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1286170005364 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1286170005365 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1286170005366 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1286170005367 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1286170005368 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1286170005369 active site 1286170005370 DNA binding site [nucleotide binding] 1286170005371 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1286170005372 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1286170005373 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1286170005374 Catalytic site [active] 1286170005375 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1286170005376 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170005377 DNA binding residues [nucleotide binding] 1286170005378 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286170005379 dimerization interface [polypeptide binding]; other site 1286170005380 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1286170005381 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286170005382 peptide binding site [polypeptide binding]; other site 1286170005383 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1286170005384 putative active site [active] 1286170005385 Zn binding site [ion binding]; other site 1286170005386 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1286170005387 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1286170005388 active site 1286170005389 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1286170005390 dimer interface [polypeptide binding]; other site 1286170005391 catalytic triad [active] 1286170005392 peroxidatic and resolving cysteines [active] 1286170005393 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1286170005394 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1286170005395 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1286170005396 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1286170005397 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1286170005398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286170005399 putative active site [active] 1286170005400 heme pocket [chemical binding]; other site 1286170005401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170005402 Walker A motif; other site 1286170005403 ATP binding site [chemical binding]; other site 1286170005404 Walker B motif; other site 1286170005405 arginine finger; other site 1286170005406 hypothetical protein; Provisional; Region: PRK05415 1286170005407 Domain of unknown function (DUF697); Region: DUF697; cl12064 1286170005408 Predicted ATPase [General function prediction only]; Region: COG3106 1286170005409 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1286170005410 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1286170005411 phage shock protein C; Region: phageshock_pspC; TIGR02978 1286170005412 phage shock protein B; Provisional; Region: pspB; PRK09458 1286170005413 phage shock protein PspA; Provisional; Region: PRK10698 1286170005414 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1286170005415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170005416 Walker A motif; other site 1286170005417 ATP binding site [chemical binding]; other site 1286170005418 Walker B motif; other site 1286170005419 arginine finger; other site 1286170005420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170005421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170005422 putative substrate translocation pore; other site 1286170005423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170005424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286170005425 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286170005426 Probable transposase; Region: OrfB_IS605; pfam01385 1286170005427 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286170005428 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1286170005429 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286170005430 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1286170005431 metal binding site [ion binding]; metal-binding site 1286170005432 putative dimer interface [polypeptide binding]; other site 1286170005433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170005434 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170005435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170005436 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1286170005437 Helix-turn-helix domain; Region: HTH_31; pfam13560 1286170005438 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286170005439 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1286170005440 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1286170005441 putative NAD(P) binding site [chemical binding]; other site 1286170005442 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1286170005443 active site 1286170005444 P-loop; other site 1286170005445 phosphorylation site [posttranslational modification] 1286170005446 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286170005447 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1286170005448 peptide binding site [polypeptide binding]; other site 1286170005449 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1286170005450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170005451 dimer interface [polypeptide binding]; other site 1286170005452 conserved gate region; other site 1286170005453 putative PBP binding loops; other site 1286170005454 ABC-ATPase subunit interface; other site 1286170005455 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1286170005456 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1286170005457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170005458 dimer interface [polypeptide binding]; other site 1286170005459 conserved gate region; other site 1286170005460 putative PBP binding loops; other site 1286170005461 ABC-ATPase subunit interface; other site 1286170005462 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1286170005463 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170005464 Walker A/P-loop; other site 1286170005465 ATP binding site [chemical binding]; other site 1286170005466 Q-loop/lid; other site 1286170005467 ABC transporter signature motif; other site 1286170005468 Walker B; other site 1286170005469 D-loop; other site 1286170005470 H-loop/switch region; other site 1286170005471 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286170005472 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1286170005473 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170005474 Walker A/P-loop; other site 1286170005475 ATP binding site [chemical binding]; other site 1286170005476 Q-loop/lid; other site 1286170005477 ABC transporter signature motif; other site 1286170005478 Walker B; other site 1286170005479 D-loop; other site 1286170005480 H-loop/switch region; other site 1286170005481 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1286170005482 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1286170005483 Na binding site [ion binding]; other site 1286170005484 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1286170005485 active sites [active] 1286170005486 tetramer interface [polypeptide binding]; other site 1286170005487 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1286170005488 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286170005489 Walker A/P-loop; other site 1286170005490 ATP binding site [chemical binding]; other site 1286170005491 Q-loop/lid; other site 1286170005492 ABC transporter signature motif; other site 1286170005493 Walker B; other site 1286170005494 D-loop; other site 1286170005495 H-loop/switch region; other site 1286170005496 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170005497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170005498 dimer interface [polypeptide binding]; other site 1286170005499 conserved gate region; other site 1286170005500 putative PBP binding loops; other site 1286170005501 ABC-ATPase subunit interface; other site 1286170005502 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170005503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170005504 dimer interface [polypeptide binding]; other site 1286170005505 conserved gate region; other site 1286170005506 putative PBP binding loops; other site 1286170005507 ABC-ATPase subunit interface; other site 1286170005508 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1286170005509 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170005510 substrate binding pocket [chemical binding]; other site 1286170005511 membrane-bound complex binding site; other site 1286170005512 hinge residues; other site 1286170005513 HutD; Region: HutD; pfam05962 1286170005514 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1286170005515 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1286170005516 NAD binding site [chemical binding]; other site 1286170005517 homotetramer interface [polypeptide binding]; other site 1286170005518 homodimer interface [polypeptide binding]; other site 1286170005519 substrate binding site [chemical binding]; other site 1286170005520 active site 1286170005521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1286170005522 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1286170005523 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1286170005524 exoribonuclease II; Provisional; Region: PRK05054 1286170005525 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1286170005526 RNB domain; Region: RNB; pfam00773 1286170005527 S1 RNA binding domain; Region: S1; pfam00575 1286170005528 hypothetical protein; Provisional; Region: PRK13658 1286170005529 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286170005530 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1286170005531 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286170005532 lipoprotein; Provisional; Region: PRK10540 1286170005533 translation initiation factor Sui1; Validated; Region: PRK06824 1286170005534 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1286170005535 putative rRNA binding site [nucleotide binding]; other site 1286170005536 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1286170005537 active site 1286170005538 dimer interface [polypeptide binding]; other site 1286170005539 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1286170005540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1286170005541 TPR motif; other site 1286170005542 binding surface 1286170005543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1286170005544 binding surface 1286170005545 TPR motif; other site 1286170005546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286170005547 binding surface 1286170005548 TPR motif; other site 1286170005549 Predicted membrane protein [Function unknown]; Region: COG3771 1286170005550 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1286170005551 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1286170005552 active site 1286170005553 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1286170005554 dimerization interface [polypeptide binding]; other site 1286170005555 active site 1286170005556 aconitate hydratase; Validated; Region: PRK09277 1286170005557 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1286170005558 substrate binding site [chemical binding]; other site 1286170005559 ligand binding site [chemical binding]; other site 1286170005560 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1286170005561 substrate binding site [chemical binding]; other site 1286170005562 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1286170005563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170005564 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1286170005565 substrate binding site [chemical binding]; other site 1286170005566 putative dimerization interface [polypeptide binding]; other site 1286170005567 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1286170005568 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1286170005569 active site 1286170005570 interdomain interaction site; other site 1286170005571 putative metal-binding site [ion binding]; other site 1286170005572 nucleotide binding site [chemical binding]; other site 1286170005573 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1286170005574 domain I; other site 1286170005575 DNA binding groove [nucleotide binding] 1286170005576 phosphate binding site [ion binding]; other site 1286170005577 domain II; other site 1286170005578 domain III; other site 1286170005579 nucleotide binding site [chemical binding]; other site 1286170005580 catalytic site [active] 1286170005581 domain IV; other site 1286170005582 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1286170005583 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1286170005584 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1286170005585 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1286170005586 hypothetical protein; Provisional; Region: PRK11037 1286170005587 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1286170005588 putative inner membrane peptidase; Provisional; Region: PRK11778 1286170005589 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1286170005590 tandem repeat interface [polypeptide binding]; other site 1286170005591 oligomer interface [polypeptide binding]; other site 1286170005592 active site residues [active] 1286170005593 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1286170005594 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1286170005595 NADP binding site [chemical binding]; other site 1286170005596 homodimer interface [polypeptide binding]; other site 1286170005597 active site 1286170005598 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1286170005599 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1286170005600 homodimer interface [polypeptide binding]; other site 1286170005601 Walker A motif; other site 1286170005602 ATP binding site [chemical binding]; other site 1286170005603 hydroxycobalamin binding site [chemical binding]; other site 1286170005604 Walker B motif; other site 1286170005605 Cupin domain; Region: Cupin_2; pfam07883 1286170005606 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170005607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170005608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170005609 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1286170005610 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1286170005611 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1286170005612 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1286170005613 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1286170005614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170005615 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1286170005616 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286170005617 RNA binding surface [nucleotide binding]; other site 1286170005618 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1286170005619 probable active site [active] 1286170005620 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1286170005621 hypothetical protein; Provisional; Region: PRK11630 1286170005622 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1286170005623 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1286170005624 active site 1286170005625 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1286170005626 anthranilate synthase component I; Provisional; Region: PRK13564 1286170005627 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1286170005628 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1286170005629 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1286170005630 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1286170005631 glutamine binding [chemical binding]; other site 1286170005632 catalytic triad [active] 1286170005633 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1286170005634 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1286170005635 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1286170005636 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1286170005637 active site 1286170005638 ribulose/triose binding site [chemical binding]; other site 1286170005639 phosphate binding site [ion binding]; other site 1286170005640 substrate (anthranilate) binding pocket [chemical binding]; other site 1286170005641 product (indole) binding pocket [chemical binding]; other site 1286170005642 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1286170005643 active site 1286170005644 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1286170005645 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1286170005646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170005647 catalytic residue [active] 1286170005648 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1286170005649 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1286170005650 substrate binding site [chemical binding]; other site 1286170005651 active site 1286170005652 catalytic residues [active] 1286170005653 heterodimer interface [polypeptide binding]; other site 1286170005654 MarR family; Region: MarR_2; pfam12802 1286170005655 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286170005656 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1286170005657 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1286170005658 putative NAD(P) binding site [chemical binding]; other site 1286170005659 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286170005660 NAD(P) binding site [chemical binding]; other site 1286170005661 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170005662 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1286170005663 putative substrate binding pocket [chemical binding]; other site 1286170005664 putative dimerization interface [polypeptide binding]; other site 1286170005665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170005666 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1286170005667 NAD(P) binding site [chemical binding]; other site 1286170005668 active site 1286170005669 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1286170005670 putative metal binding site [ion binding]; other site 1286170005671 putative homodimer interface [polypeptide binding]; other site 1286170005672 putative homotetramer interface [polypeptide binding]; other site 1286170005673 putative homodimer-homodimer interface [polypeptide binding]; other site 1286170005674 putative allosteric switch controlling residues; other site 1286170005675 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1286170005676 High-affinity nickel-transport protein; Region: NicO; cl00964 1286170005677 outer membrane protein W; Provisional; Region: PRK10959 1286170005678 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1286170005679 hypothetical protein; Provisional; Region: PRK02868 1286170005680 intracellular septation protein A; Reviewed; Region: PRK00259 1286170005681 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 1286170005682 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1286170005683 putative Cl- selectivity filter; other site 1286170005684 putative pore gating glutamate residue; other site 1286170005685 outer membrane receptor FepA; Provisional; Region: PRK13528 1286170005686 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170005687 N-terminal plug; other site 1286170005688 ligand-binding site [chemical binding]; other site 1286170005689 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1286170005690 YniB-like protein; Region: YniB; pfam14002 1286170005691 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1286170005692 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1286170005693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170005694 motif II; other site 1286170005695 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1286170005696 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1286170005697 NADP binding site [chemical binding]; other site 1286170005698 homodimer interface [polypeptide binding]; other site 1286170005699 active site 1286170005700 inner membrane protein; Provisional; Region: PRK11648 1286170005701 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1286170005702 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1286170005703 cell division modulator; Provisional; Region: PRK10113 1286170005704 hydroperoxidase II; Provisional; Region: katE; PRK11249 1286170005705 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1286170005706 tetramer interface [polypeptide binding]; other site 1286170005707 heme binding pocket [chemical binding]; other site 1286170005708 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1286170005709 domain interactions; other site 1286170005710 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1286170005711 putative active site [active] 1286170005712 YdjC motif; other site 1286170005713 Mg binding site [ion binding]; other site 1286170005714 putative homodimer interface [polypeptide binding]; other site 1286170005715 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1286170005716 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1286170005717 NAD binding site [chemical binding]; other site 1286170005718 sugar binding site [chemical binding]; other site 1286170005719 divalent metal binding site [ion binding]; other site 1286170005720 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286170005721 dimer interface [polypeptide binding]; other site 1286170005722 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1286170005723 Cupin domain; Region: Cupin_2; pfam07883 1286170005724 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170005725 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1286170005726 methionine cluster; other site 1286170005727 active site 1286170005728 phosphorylation site [posttranslational modification] 1286170005729 metal binding site [ion binding]; metal-binding site 1286170005730 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1286170005731 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1286170005732 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1286170005733 active site 1286170005734 P-loop; other site 1286170005735 phosphorylation site [posttranslational modification] 1286170005736 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1286170005737 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1286170005738 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1286170005739 homodimer interface [polypeptide binding]; other site 1286170005740 NAD binding pocket [chemical binding]; other site 1286170005741 ATP binding pocket [chemical binding]; other site 1286170005742 Mg binding site [ion binding]; other site 1286170005743 active-site loop [active] 1286170005744 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1286170005745 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1286170005746 GIY-YIG motif/motif A; other site 1286170005747 active site 1286170005748 catalytic site [active] 1286170005749 putative DNA binding site [nucleotide binding]; other site 1286170005750 metal binding site [ion binding]; metal-binding site 1286170005751 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1286170005752 dimer interface [polypeptide binding]; other site 1286170005753 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1286170005754 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1286170005755 putative active site [active] 1286170005756 Zn binding site [ion binding]; other site 1286170005757 succinylarginine dihydrolase; Provisional; Region: PRK13281 1286170005758 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1286170005759 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1286170005760 NAD(P) binding site [chemical binding]; other site 1286170005761 catalytic residues [active] 1286170005762 arginine succinyltransferase; Provisional; Region: PRK10456 1286170005763 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1286170005764 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1286170005765 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286170005766 inhibitor-cofactor binding pocket; inhibition site 1286170005767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170005768 catalytic residue [active] 1286170005769 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1286170005770 putative catalytic site [active] 1286170005771 putative phosphate binding site [ion binding]; other site 1286170005772 active site 1286170005773 metal binding site A [ion binding]; metal-binding site 1286170005774 DNA binding site [nucleotide binding] 1286170005775 putative AP binding site [nucleotide binding]; other site 1286170005776 putative metal binding site B [ion binding]; other site 1286170005777 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1286170005778 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286170005779 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1286170005780 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286170005781 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1286170005782 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1286170005783 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1286170005784 hypothetical protein; Provisional; Region: PRK11622 1286170005785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170005786 ABC-ATPase subunit interface; other site 1286170005787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170005788 Walker A/P-loop; other site 1286170005789 ATP binding site [chemical binding]; other site 1286170005790 ABC transporter; Region: ABC_tran; pfam00005 1286170005791 Q-loop/lid; other site 1286170005792 ABC transporter signature motif; other site 1286170005793 Walker B; other site 1286170005794 D-loop; other site 1286170005795 H-loop/switch region; other site 1286170005796 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1286170005797 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1286170005798 active site residue [active] 1286170005799 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1286170005800 active site residue [active] 1286170005801 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1286170005802 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1286170005803 active site 1286170005804 8-oxo-dGMP binding site [chemical binding]; other site 1286170005805 nudix motif; other site 1286170005806 metal binding site [ion binding]; metal-binding site 1286170005807 glutamate dehydrogenase; Provisional; Region: PRK09414 1286170005808 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1286170005809 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1286170005810 NAD(P) binding site [chemical binding]; other site 1286170005811 DNA topoisomerase III; Provisional; Region: PRK07726 1286170005812 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1286170005813 active site 1286170005814 putative interdomain interaction site [polypeptide binding]; other site 1286170005815 putative metal-binding site [ion binding]; other site 1286170005816 putative nucleotide binding site [chemical binding]; other site 1286170005817 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1286170005818 domain I; other site 1286170005819 DNA binding groove [nucleotide binding] 1286170005820 phosphate binding site [ion binding]; other site 1286170005821 domain II; other site 1286170005822 domain III; other site 1286170005823 nucleotide binding site [chemical binding]; other site 1286170005824 catalytic site [active] 1286170005825 domain IV; other site 1286170005826 selenophosphate synthetase; Provisional; Region: PRK00943 1286170005827 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1286170005828 dimerization interface [polypeptide binding]; other site 1286170005829 putative ATP binding site [chemical binding]; other site 1286170005830 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286170005831 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170005832 DNA-binding site [nucleotide binding]; DNA binding site 1286170005833 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1286170005834 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1286170005835 active site 1286170005836 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1286170005837 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1286170005838 putative FMN binding site [chemical binding]; other site 1286170005839 protease 4; Provisional; Region: PRK10949 1286170005840 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1286170005841 tandem repeat interface [polypeptide binding]; other site 1286170005842 oligomer interface [polypeptide binding]; other site 1286170005843 active site residues [active] 1286170005844 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1286170005845 tandem repeat interface [polypeptide binding]; other site 1286170005846 oligomer interface [polypeptide binding]; other site 1286170005847 active site residues [active] 1286170005848 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1286170005849 active site 1286170005850 homodimer interface [polypeptide binding]; other site 1286170005851 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1286170005852 Isochorismatase family; Region: Isochorismatase; pfam00857 1286170005853 catalytic triad [active] 1286170005854 metal binding site [ion binding]; metal-binding site 1286170005855 conserved cis-peptide bond; other site 1286170005856 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1286170005857 Glyco_18 domain; Region: Glyco_18; smart00636 1286170005858 active site 1286170005859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1286170005860 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1286170005861 SelR domain; Region: SelR; pfam01641 1286170005862 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1286170005863 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1286170005864 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1286170005865 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1286170005866 active site 1286170005867 phosphate binding residues; other site 1286170005868 catalytic residues [active] 1286170005869 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1286170005870 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1286170005871 transmembrane helices; other site 1286170005872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170005873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170005874 active site 1286170005875 catalytic tetrad [active] 1286170005876 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1286170005877 PrkA family serine protein kinase; Provisional; Region: PRK15455 1286170005878 AAA ATPase domain; Region: AAA_16; pfam13191 1286170005879 Walker A motif; other site 1286170005880 ATP binding site [chemical binding]; other site 1286170005881 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1286170005882 hypothetical protein; Provisional; Region: PRK05325 1286170005883 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1286170005884 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1286170005885 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286170005886 active site 1286170005887 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1286170005888 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1286170005889 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1286170005890 putative deacylase active site [active] 1286170005891 Predicted membrane protein [Function unknown]; Region: COG2707 1286170005892 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170005893 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170005894 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1286170005895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170005896 putative substrate translocation pore; other site 1286170005897 hypothetical protein; Validated; Region: PRK06186 1286170005898 conserved cys residue [active] 1286170005899 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1286170005900 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1286170005901 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1286170005902 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1286170005903 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1286170005904 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170005905 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170005906 metal binding site [ion binding]; metal-binding site 1286170005907 active site 1286170005908 I-site; other site 1286170005909 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1286170005910 leucine export protein LeuE; Provisional; Region: PRK10958 1286170005911 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1286170005912 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1286170005913 putative acyl-acceptor binding pocket; other site 1286170005914 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1286170005915 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286170005916 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286170005917 DNA binding residues [nucleotide binding] 1286170005918 fec operon regulator FecR; Reviewed; Region: PRK09774 1286170005919 FecR protein; Region: FecR; pfam04773 1286170005920 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1286170005921 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170005922 N-terminal plug; other site 1286170005923 ligand-binding site [chemical binding]; other site 1286170005924 HD domain; Region: HD; pfam01966 1286170005925 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286170005926 Zn2+ binding site [ion binding]; other site 1286170005927 Mg2+ binding site [ion binding]; other site 1286170005928 HAMP domain; Region: HAMP; pfam00672 1286170005929 dimerization interface [polypeptide binding]; other site 1286170005930 GAF domain; Region: GAF_3; pfam13492 1286170005931 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170005932 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170005933 metal binding site [ion binding]; metal-binding site 1286170005934 active site 1286170005935 I-site; other site 1286170005936 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286170005937 catalytic core [active] 1286170005938 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1286170005939 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286170005940 DNA-binding site [nucleotide binding]; DNA binding site 1286170005941 RNA-binding motif; other site 1286170005942 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1286170005943 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1286170005944 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286170005945 Walker A/P-loop; other site 1286170005946 ATP binding site [chemical binding]; other site 1286170005947 Q-loop/lid; other site 1286170005948 ABC transporter signature motif; other site 1286170005949 Walker B; other site 1286170005950 D-loop; other site 1286170005951 H-loop/switch region; other site 1286170005952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170005953 dimer interface [polypeptide binding]; other site 1286170005954 conserved gate region; other site 1286170005955 putative PBP binding loops; other site 1286170005956 ABC-ATPase subunit interface; other site 1286170005957 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1286170005958 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170005959 substrate binding pocket [chemical binding]; other site 1286170005960 membrane-bound complex binding site; other site 1286170005961 hinge residues; other site 1286170005962 hypothetical protein; Provisional; Region: PRK07483 1286170005963 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286170005964 inhibitor-cofactor binding pocket; inhibition site 1286170005965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170005966 catalytic residue [active] 1286170005967 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286170005968 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170005969 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170005970 putative active site [active] 1286170005971 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1286170005972 methionine synthase; Provisional; Region: PRK01207 1286170005973 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1286170005974 substrate binding site [chemical binding]; other site 1286170005975 THF binding site; other site 1286170005976 zinc-binding site [ion binding]; other site 1286170005977 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286170005978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170005979 Coenzyme A binding pocket [chemical binding]; other site 1286170005980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1286170005981 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170005982 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170005983 metal binding site [ion binding]; metal-binding site 1286170005984 active site 1286170005985 I-site; other site 1286170005986 LysE type translocator; Region: LysE; cl00565 1286170005987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170005988 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170005989 putative substrate translocation pore; other site 1286170005990 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1286170005991 isocitrate dehydrogenase; Validated; Region: PRK07362 1286170005992 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1286170005993 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1286170005994 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1286170005995 probable active site [active] 1286170005996 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1286170005997 nudix motif; other site 1286170005998 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1286170005999 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1286170006000 putative lysogenization regulator; Reviewed; Region: PRK00218 1286170006001 adenylosuccinate lyase; Provisional; Region: PRK09285 1286170006002 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1286170006003 tetramer interface [polypeptide binding]; other site 1286170006004 active site 1286170006005 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1286170006006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170006007 active site 1286170006008 phosphorylation site [posttranslational modification] 1286170006009 intermolecular recognition site; other site 1286170006010 dimerization interface [polypeptide binding]; other site 1286170006011 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170006012 DNA binding site [nucleotide binding] 1286170006013 sensor protein PhoQ; Provisional; Region: PRK10815 1286170006014 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1286170006015 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1286170006016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170006017 ATP binding site [chemical binding]; other site 1286170006018 Mg2+ binding site [ion binding]; other site 1286170006019 G-X-G motif; other site 1286170006020 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1286170006021 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1286170006022 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1286170006023 metal binding site [ion binding]; metal-binding site 1286170006024 dimer interface [polypeptide binding]; other site 1286170006025 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1286170006026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170006027 Walker A/P-loop; other site 1286170006028 ATP binding site [chemical binding]; other site 1286170006029 Q-loop/lid; other site 1286170006030 ABC transporter signature motif; other site 1286170006031 Walker B; other site 1286170006032 D-loop; other site 1286170006033 H-loop/switch region; other site 1286170006034 TOBE domain; Region: TOBE_2; pfam08402 1286170006035 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286170006036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170006037 dimer interface [polypeptide binding]; other site 1286170006038 conserved gate region; other site 1286170006039 putative PBP binding loops; other site 1286170006040 ABC-ATPase subunit interface; other site 1286170006041 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286170006042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170006043 dimer interface [polypeptide binding]; other site 1286170006044 conserved gate region; other site 1286170006045 putative PBP binding loops; other site 1286170006046 ABC-ATPase subunit interface; other site 1286170006047 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1286170006048 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1286170006049 Phospholipid methyltransferase; Region: PEMT; cl17370 1286170006050 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 1286170006051 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1286170006052 dimer interface [polypeptide binding]; other site 1286170006053 acyl-activating enzyme (AAE) consensus motif; other site 1286170006054 putative active site [active] 1286170006055 AMP binding site [chemical binding]; other site 1286170006056 putative CoA binding site [chemical binding]; other site 1286170006057 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286170006058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170006059 active site 1286170006060 phosphorylation site [posttranslational modification] 1286170006061 intermolecular recognition site; other site 1286170006062 dimerization interface [polypeptide binding]; other site 1286170006063 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170006064 DNA binding site [nucleotide binding] 1286170006065 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1286170006066 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1286170006067 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1286170006068 Moco binding site; other site 1286170006069 metal coordination site [ion binding]; other site 1286170006070 transketolase; Reviewed; Region: PRK12753 1286170006071 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1286170006072 TPP-binding site [chemical binding]; other site 1286170006073 dimer interface [polypeptide binding]; other site 1286170006074 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286170006075 PYR/PP interface [polypeptide binding]; other site 1286170006076 dimer interface [polypeptide binding]; other site 1286170006077 TPP binding site [chemical binding]; other site 1286170006078 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286170006079 transaldolase-like protein; Provisional; Region: PTZ00411 1286170006080 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1286170006081 active site 1286170006082 dimer interface [polypeptide binding]; other site 1286170006083 catalytic residue [active] 1286170006084 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1286170006085 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1286170006086 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1286170006087 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1286170006088 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1286170006089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1286170006090 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1286170006091 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1286170006092 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1286170006093 substrate binding site [chemical binding]; other site 1286170006094 dimer interface [polypeptide binding]; other site 1286170006095 triosephosphate isomerase; Provisional; Region: PRK14565 1286170006096 catalytic triad [active] 1286170006097 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286170006098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286170006099 DNA binding residues [nucleotide binding] 1286170006100 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286170006101 NAD-dependent deacetylase; Provisional; Region: PRK00481 1286170006102 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1286170006103 NAD+ binding site [chemical binding]; other site 1286170006104 substrate binding site [chemical binding]; other site 1286170006105 Zn binding site [ion binding]; other site 1286170006106 fructokinase; Reviewed; Region: PRK09557 1286170006107 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286170006108 nucleotide binding site [chemical binding]; other site 1286170006109 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1286170006110 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286170006111 FtsX-like permease family; Region: FtsX; pfam02687 1286170006112 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1286170006113 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286170006114 Walker A/P-loop; other site 1286170006115 ATP binding site [chemical binding]; other site 1286170006116 Q-loop/lid; other site 1286170006117 ABC transporter signature motif; other site 1286170006118 Walker B; other site 1286170006119 D-loop; other site 1286170006120 H-loop/switch region; other site 1286170006121 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1286170006122 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286170006123 FtsX-like permease family; Region: FtsX; pfam02687 1286170006124 transcription-repair coupling factor; Provisional; Region: PRK10689 1286170006125 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1286170006126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286170006127 ATP binding site [chemical binding]; other site 1286170006128 putative Mg++ binding site [ion binding]; other site 1286170006129 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170006130 nucleotide binding region [chemical binding]; other site 1286170006131 ATP-binding site [chemical binding]; other site 1286170006132 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1286170006133 L,D-transpeptidase; Provisional; Region: PRK10190 1286170006134 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286170006135 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286170006136 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1286170006137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286170006138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170006139 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1286170006140 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170006141 N-terminal plug; other site 1286170006142 ligand-binding site [chemical binding]; other site 1286170006143 hypothetical protein; Provisional; Region: PRK11280 1286170006144 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1286170006145 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170006146 hypothetical protein; Provisional; Region: PRK04940 1286170006147 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1286170006148 beta-hexosaminidase; Provisional; Region: PRK05337 1286170006149 thiamine kinase; Region: ycfN_thiK; TIGR02721 1286170006150 active site 1286170006151 substrate binding site [chemical binding]; other site 1286170006152 ATP binding site [chemical binding]; other site 1286170006153 thiamine kinase; Provisional; Region: thiK; PRK10271 1286170006154 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1286170006155 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1286170006156 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1286170006157 putative dimer interface [polypeptide binding]; other site 1286170006158 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1286170006159 nucleotide binding site/active site [active] 1286170006160 HIT family signature motif; other site 1286170006161 catalytic residue [active] 1286170006162 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1286170006163 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170006164 N-terminal plug; other site 1286170006165 ligand-binding site [chemical binding]; other site 1286170006166 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1286170006167 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286170006168 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170006169 active site turn [active] 1286170006170 phosphorylation site [posttranslational modification] 1286170006171 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1286170006172 active site 1286170006173 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1286170006174 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1286170006175 thymidylate kinase; Validated; Region: tmk; PRK00698 1286170006176 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1286170006177 TMP-binding site; other site 1286170006178 ATP-binding site [chemical binding]; other site 1286170006179 conserved hypothetical protein, YceG family; Region: TIGR00247 1286170006180 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1286170006181 dimerization interface [polypeptide binding]; other site 1286170006182 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1286170006183 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1286170006184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170006185 catalytic residue [active] 1286170006186 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1286170006187 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1286170006188 dimer interface [polypeptide binding]; other site 1286170006189 active site 1286170006190 acyl carrier protein; Provisional; Region: acpP; PRK00982 1286170006191 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1286170006192 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1286170006193 NAD(P) binding site [chemical binding]; other site 1286170006194 homotetramer interface [polypeptide binding]; other site 1286170006195 homodimer interface [polypeptide binding]; other site 1286170006196 active site 1286170006197 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1286170006198 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1286170006199 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1286170006200 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1286170006201 dimer interface [polypeptide binding]; other site 1286170006202 active site 1286170006203 CoA binding pocket [chemical binding]; other site 1286170006204 putative phosphate acyltransferase; Provisional; Region: PRK05331 1286170006205 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1286170006206 hypothetical protein; Provisional; Region: PRK11193 1286170006207 Maf-like protein; Region: Maf; pfam02545 1286170006208 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1286170006209 active site 1286170006210 dimer interface [polypeptide binding]; other site 1286170006211 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1286170006212 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286170006213 RNA binding surface [nucleotide binding]; other site 1286170006214 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1286170006215 active site 1286170006216 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1286170006217 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1286170006218 homodimer interface [polypeptide binding]; other site 1286170006219 oligonucleotide binding site [chemical binding]; other site 1286170006220 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1286170006221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170006222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170006223 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170006224 putative effector binding pocket; other site 1286170006225 dimerization interface [polypeptide binding]; other site 1286170006226 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286170006227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170006228 putative substrate translocation pore; other site 1286170006229 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1286170006230 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1286170006231 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286170006232 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286170006233 hypothetical protein; Provisional; Region: PRK11239 1286170006234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1286170006235 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1286170006236 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286170006237 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1286170006238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170006239 putative substrate translocation pore; other site 1286170006240 lipoprotein; Provisional; Region: PRK10598 1286170006241 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1286170006242 active site 1286170006243 substrate binding pocket [chemical binding]; other site 1286170006244 dimer interface [polypeptide binding]; other site 1286170006245 DNA damage-inducible protein I; Provisional; Region: PRK10597 1286170006246 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1286170006247 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1286170006248 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286170006249 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1286170006250 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1286170006251 active site residue [active] 1286170006252 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1286170006253 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1286170006254 putative acyl-acceptor binding pocket; other site 1286170006255 drug efflux system protein MdtG; Provisional; Region: PRK09874 1286170006256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170006257 putative substrate translocation pore; other site 1286170006258 secY/secA suppressor protein; Provisional; Region: PRK11467 1286170006259 lipoprotein; Provisional; Region: PRK10175 1286170006260 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286170006261 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1286170006262 Ligand binding site; other site 1286170006263 DXD motif; other site 1286170006264 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1286170006265 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1286170006266 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1286170006267 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1286170006268 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1286170006269 putative ADP-ribose binding site [chemical binding]; other site 1286170006270 putative active site [active] 1286170006271 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1286170006272 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1286170006273 putative hydrolase; Validated; Region: PRK09248 1286170006274 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1286170006275 active site 1286170006276 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1286170006277 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1286170006278 putative ligand binding site [chemical binding]; other site 1286170006279 NAD binding site [chemical binding]; other site 1286170006280 dimerization interface [polypeptide binding]; other site 1286170006281 catalytic site [active] 1286170006282 LysR family transcriptional regulator; Provisional; Region: PRK14997 1286170006283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170006284 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1286170006285 putative effector binding pocket; other site 1286170006286 putative dimerization interface [polypeptide binding]; other site 1286170006287 Pirin-related protein [General function prediction only]; Region: COG1741 1286170006288 Pirin; Region: Pirin; pfam02678 1286170006289 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1286170006290 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1286170006291 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170006292 N-terminal plug; other site 1286170006293 ligand-binding site [chemical binding]; other site 1286170006294 potential frameshift: common BLAST hit: gi|386311231|ref|YP_006007287.1| periplasmic binding protein 1286170006295 benzoate transport; Region: 2A0115; TIGR00895 1286170006296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170006297 putative substrate translocation pore; other site 1286170006298 hypothetical protein; Provisional; Region: PRK10536 1286170006299 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1286170006300 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1286170006301 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1286170006302 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1286170006303 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1286170006304 Imelysin; Region: Peptidase_M75; pfam09375 1286170006305 FTR1 family protein; Region: TIGR00145 1286170006306 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1286170006307 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1286170006308 Nucleoside recognition; Region: Gate; pfam07670 1286170006309 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1286170006310 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1286170006311 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1286170006312 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1286170006313 Na binding site [ion binding]; other site 1286170006314 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1286170006315 Predicted transcriptional regulator [Transcription]; Region: COG3905 1286170006316 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1286170006317 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1286170006318 Glutamate binding site [chemical binding]; other site 1286170006319 NAD binding site [chemical binding]; other site 1286170006320 catalytic residues [active] 1286170006321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1286170006322 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1286170006323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170006324 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1286170006325 pyrimidine utilization protein A; Region: RutA; TIGR03612 1286170006326 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1286170006327 active site 1286170006328 dimer interface [polypeptide binding]; other site 1286170006329 non-prolyl cis peptide bond; other site 1286170006330 insertion regions; other site 1286170006331 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286170006332 Isochorismatase family; Region: Isochorismatase; pfam00857 1286170006333 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1286170006334 catalytic triad [active] 1286170006335 conserved cis-peptide bond; other site 1286170006336 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286170006337 homotrimer interaction site [polypeptide binding]; other site 1286170006338 putative active site [active] 1286170006339 pyrimidine utilization protein D; Region: RutD; TIGR03611 1286170006340 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1286170006341 putative FMN binding site [chemical binding]; other site 1286170006342 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 1286170006343 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1286170006344 General stress protein [General function prediction only]; Region: GsiB; COG3729 1286170006345 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1286170006346 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286170006347 hypothetical protein; Provisional; Region: PRK10174 1286170006348 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1286170006349 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1286170006350 catalytic core [active] 1286170006351 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1286170006352 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286170006353 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286170006354 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1286170006355 classical (c) SDRs; Region: SDR_c; cd05233 1286170006356 NAD(P) binding site [chemical binding]; other site 1286170006357 active site 1286170006358 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286170006359 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286170006360 short chain dehydrogenase; Provisional; Region: PRK06500 1286170006361 classical (c) SDRs; Region: SDR_c; cd05233 1286170006362 NAD(P) binding site [chemical binding]; other site 1286170006363 active site 1286170006364 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1286170006365 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1286170006366 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1286170006367 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 1286170006368 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1286170006369 catalytic triad [active] 1286170006370 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1286170006371 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170006372 non-specific DNA binding site [nucleotide binding]; other site 1286170006373 salt bridge; other site 1286170006374 sequence-specific DNA binding site [nucleotide binding]; other site 1286170006375 Cupin domain; Region: Cupin_2; pfam07883 1286170006376 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1286170006377 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1286170006378 NAD(P) binding site [chemical binding]; other site 1286170006379 catalytic residues [active] 1286170006380 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286170006381 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286170006382 transcriptional activator TtdR; Provisional; Region: PRK09801 1286170006383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170006384 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1286170006385 putative effector binding pocket; other site 1286170006386 putative dimerization interface [polypeptide binding]; other site 1286170006387 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1286170006388 tartrate dehydrogenase; Region: TTC; TIGR02089 1286170006389 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1286170006390 dimerization domain swap beta strand [polypeptide binding]; other site 1286170006391 regulatory protein interface [polypeptide binding]; other site 1286170006392 active site 1286170006393 regulatory phosphorylation site [posttranslational modification]; other site 1286170006394 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1286170006395 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1286170006396 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1286170006397 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1286170006398 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286170006399 active site 1286170006400 phosphorylation site [posttranslational modification] 1286170006401 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1286170006402 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1286170006403 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1286170006404 active site 1286170006405 P-loop; other site 1286170006406 phosphorylation site [posttranslational modification] 1286170006407 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 1286170006408 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1286170006409 dimer interface [polypeptide binding]; other site 1286170006410 active site 1286170006411 glycine loop; other site 1286170006412 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170006413 FeS/SAM binding site; other site 1286170006414 pyruvate formate lyase II activase; Provisional; Region: PRK10076 1286170006415 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1286170006416 active site 1286170006417 P-loop; other site 1286170006418 phosphorylation site [posttranslational modification] 1286170006419 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1286170006420 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170006421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170006422 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170006423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170006424 metal binding site [ion binding]; metal-binding site 1286170006425 active site 1286170006426 I-site; other site 1286170006427 allantoate amidohydrolase; Reviewed; Region: PRK09290 1286170006428 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1286170006429 active site 1286170006430 metal binding site [ion binding]; metal-binding site 1286170006431 dimer interface [polypeptide binding]; other site 1286170006432 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1286170006433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286170006434 catalytic residue [active] 1286170006435 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286170006436 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286170006437 Walker A/P-loop; other site 1286170006438 ATP binding site [chemical binding]; other site 1286170006439 Q-loop/lid; other site 1286170006440 ABC transporter signature motif; other site 1286170006441 Walker B; other site 1286170006442 D-loop; other site 1286170006443 H-loop/switch region; other site 1286170006444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170006445 dimer interface [polypeptide binding]; other site 1286170006446 conserved gate region; other site 1286170006447 putative PBP binding loops; other site 1286170006448 ABC-ATPase subunit interface; other site 1286170006449 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170006450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170006451 dimer interface [polypeptide binding]; other site 1286170006452 conserved gate region; other site 1286170006453 putative PBP binding loops; other site 1286170006454 ABC-ATPase subunit interface; other site 1286170006455 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170006456 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170006457 substrate binding pocket [chemical binding]; other site 1286170006458 membrane-bound complex binding site; other site 1286170006459 hinge residues; other site 1286170006460 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286170006461 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170006462 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1286170006463 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1286170006464 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1286170006465 amidase; Provisional; Region: PRK09201 1286170006466 Amidase; Region: Amidase; pfam01425 1286170006467 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1286170006468 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1286170006469 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1286170006470 active site 1286170006471 catalytic site [active] 1286170006472 tetramer interface [polypeptide binding]; other site 1286170006473 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1286170006474 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286170006475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170006476 DNA-binding site [nucleotide binding]; DNA binding site 1286170006477 FCD domain; Region: FCD; pfam07729 1286170006478 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1286170006479 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1286170006480 Na binding site [ion binding]; other site 1286170006481 putative substrate binding site [chemical binding]; other site 1286170006482 guanine deaminase; Provisional; Region: PRK09228 1286170006483 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1286170006484 active site 1286170006485 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1286170006486 active site 1286170006487 homotetramer interface [polypeptide binding]; other site 1286170006488 OHCU decarboxylase; Region: UraD_2; TIGR03180 1286170006489 FAD binding domain; Region: FAD_binding_3; pfam01494 1286170006490 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286170006491 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170006492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170006493 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286170006494 dimerization interface [polypeptide binding]; other site 1286170006495 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1286170006496 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1286170006497 iron-sulfur cluster [ion binding]; other site 1286170006498 [2Fe-2S] cluster binding site [ion binding]; other site 1286170006499 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1286170006500 hydrophobic ligand binding site; other site 1286170006501 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1286170006502 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1286170006503 FMN-binding pocket [chemical binding]; other site 1286170006504 flavin binding motif; other site 1286170006505 phosphate binding motif [ion binding]; other site 1286170006506 beta-alpha-beta structure motif; other site 1286170006507 NAD binding pocket [chemical binding]; other site 1286170006508 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286170006509 catalytic loop [active] 1286170006510 iron binding site [ion binding]; other site 1286170006511 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1286170006512 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1286170006513 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1286170006514 Walker A/P-loop; other site 1286170006515 ATP binding site [chemical binding]; other site 1286170006516 Q-loop/lid; other site 1286170006517 ABC transporter signature motif; other site 1286170006518 Walker B; other site 1286170006519 D-loop; other site 1286170006520 H-loop/switch region; other site 1286170006521 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286170006522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170006523 dimer interface [polypeptide binding]; other site 1286170006524 conserved gate region; other site 1286170006525 ABC-ATPase subunit interface; other site 1286170006526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170006527 dimer interface [polypeptide binding]; other site 1286170006528 conserved gate region; other site 1286170006529 putative PBP binding loops; other site 1286170006530 ABC-ATPase subunit interface; other site 1286170006531 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286170006532 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286170006533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1286170006534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170006535 Coenzyme A binding pocket [chemical binding]; other site 1286170006536 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286170006537 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170006538 dimerization interface [polypeptide binding]; other site 1286170006539 DNA binding residues [nucleotide binding] 1286170006540 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286170006541 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286170006542 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170006543 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170006544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286170006545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170006546 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1286170006547 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286170006548 peptide binding site [polypeptide binding]; other site 1286170006549 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1286170006550 YccA-like proteins; Region: YccA_like; cd10433 1286170006551 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1286170006552 sulfur transfer protein TusE; Provisional; Region: PRK11508 1286170006553 acylphosphatase; Provisional; Region: PRK14426 1286170006554 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170006555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170006556 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1286170006557 substrate binding site [chemical binding]; other site 1286170006558 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1286170006559 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1286170006560 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1286170006561 putative RNA binding site [nucleotide binding]; other site 1286170006562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170006563 S-adenosylmethionine binding site [chemical binding]; other site 1286170006564 heat shock protein HspQ; Provisional; Region: PRK14129 1286170006565 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1286170006566 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1286170006567 active site 1286170006568 dimer interfaces [polypeptide binding]; other site 1286170006569 catalytic residues [active] 1286170006570 DNA helicase IV; Provisional; Region: helD; PRK11054 1286170006571 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1286170006572 Part of AAA domain; Region: AAA_19; pfam13245 1286170006573 Family description; Region: UvrD_C_2; pfam13538 1286170006574 Predicted membrane protein [Function unknown]; Region: COG3304 1286170006575 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1286170006576 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1286170006577 TIGR01666 family membrane protein; Region: YCCS 1286170006578 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1286170006579 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1286170006580 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1286170006581 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1286170006582 cell division inhibitor SulA; Region: sula; TIGR00623 1286170006583 outer membrane protein A; Reviewed; Region: PRK10808 1286170006584 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1286170006585 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1286170006586 ligand binding site [chemical binding]; other site 1286170006587 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1286170006588 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1286170006589 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1286170006590 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1286170006591 active site 1 [active] 1286170006592 dimer interface [polypeptide binding]; other site 1286170006593 active site 2 [active] 1286170006594 ribosome modulation factor; Provisional; Region: PRK14563 1286170006595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1286170006596 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1286170006597 paraquat-inducible protein B; Provisional; Region: PRK10807 1286170006598 mce related protein; Region: MCE; pfam02470 1286170006599 mce related protein; Region: MCE; pfam02470 1286170006600 mce related protein; Region: MCE; pfam02470 1286170006601 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1286170006602 Paraquat-inducible protein A; Region: PqiA; pfam04403 1286170006603 Paraquat-inducible protein A; Region: PqiA; pfam04403 1286170006604 ABC transporter ATPase component; Reviewed; Region: PRK11147 1286170006605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170006606 Walker A/P-loop; other site 1286170006607 ATP binding site [chemical binding]; other site 1286170006608 Q-loop/lid; other site 1286170006609 ABC transporter signature motif; other site 1286170006610 Walker B; other site 1286170006611 D-loop; other site 1286170006612 H-loop/switch region; other site 1286170006613 ABC transporter; Region: ABC_tran_2; pfam12848 1286170006614 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170006615 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1286170006616 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1286170006617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170006618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170006619 S-adenosylmethionine binding site [chemical binding]; other site 1286170006620 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1286170006621 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1286170006622 MOSC domain; Region: MOSC; pfam03473 1286170006623 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1286170006624 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286170006625 catalytic loop [active] 1286170006626 iron binding site [ion binding]; other site 1286170006627 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1286170006628 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1286170006629 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1286170006630 quinone interaction residues [chemical binding]; other site 1286170006631 active site 1286170006632 catalytic residues [active] 1286170006633 FMN binding site [chemical binding]; other site 1286170006634 substrate binding site [chemical binding]; other site 1286170006635 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1286170006636 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286170006637 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1286170006638 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170006639 substrate binding pocket [chemical binding]; other site 1286170006640 membrane-bound complex binding site; other site 1286170006641 hinge residues; other site 1286170006642 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1286170006643 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1286170006644 active site 1286170006645 dimer interface [polypeptide binding]; other site 1286170006646 non-prolyl cis peptide bond; other site 1286170006647 insertion regions; other site 1286170006648 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286170006649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170006650 dimer interface [polypeptide binding]; other site 1286170006651 conserved gate region; other site 1286170006652 putative PBP binding loops; other site 1286170006653 ABC-ATPase subunit interface; other site 1286170006654 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1286170006655 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286170006656 Walker A/P-loop; other site 1286170006657 ATP binding site [chemical binding]; other site 1286170006658 Q-loop/lid; other site 1286170006659 ABC transporter signature motif; other site 1286170006660 Walker B; other site 1286170006661 D-loop; other site 1286170006662 H-loop/switch region; other site 1286170006663 aminopeptidase N; Provisional; Region: pepN; PRK14015 1286170006664 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1286170006665 active site 1286170006666 Zn binding site [ion binding]; other site 1286170006667 hypothetical protein; Provisional; Region: PRK09951 1286170006668 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1286170006669 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1286170006670 active site 1286170006671 DNA binding site [nucleotide binding] 1286170006672 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1286170006673 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1286170006674 oxyanion hole [active] 1286170006675 ThiS family; Region: ThiS; pfam02597 1286170006676 NlpC/P60 family; Region: NLPC_P60; cl17555 1286170006677 Immunoglobulin domain; Region: Ig; cl11960 1286170006678 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 1286170006679 Phage-related minor tail protein [Function unknown]; Region: COG5281 1286170006680 tape measure domain; Region: tape_meas_nterm; TIGR02675 1286170006681 KilA-N domain; Region: KilA-N; pfam04383 1286170006682 Immunoglobulin domain; Region: Ig_3; pfam13927 1286170006683 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1286170006684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567 1286170006685 Phage terminase large subunit; Region: Terminase_3; cl12054 1286170006686 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 1286170006687 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1286170006688 catalytic residues [active] 1286170006689 Protein of unknown function (DUF3753); Region: DUF3753; cl17242 1286170006690 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 1286170006691 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1286170006692 prophage protein NinE; Provisional; Region: PRK09689 1286170006693 hypothetical protein; Provisional; Region: PRK09741 1286170006694 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 1286170006695 TIGR04255 family protein; Region: sporadTIGR04255 1286170006696 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1286170006697 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 1286170006698 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286170006699 Walker A motif; other site 1286170006700 ATP binding site [chemical binding]; other site 1286170006701 Walker B motif; other site 1286170006702 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1286170006703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170006704 non-specific DNA binding site [nucleotide binding]; other site 1286170006705 salt bridge; other site 1286170006706 sequence-specific DNA binding site [nucleotide binding]; other site 1286170006707 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1286170006708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170006709 non-specific DNA binding site [nucleotide binding]; other site 1286170006710 salt bridge; other site 1286170006711 sequence-specific DNA binding site [nucleotide binding]; other site 1286170006712 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1286170006713 Catalytic site [active] 1286170006714 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 1286170006715 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1286170006716 exodeoxyribonuclease X; Provisional; Region: PRK07983 1286170006717 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1286170006718 active site 1286170006719 catalytic site [active] 1286170006720 substrate binding site [chemical binding]; other site 1286170006721 AAA domain; Region: AAA_22; pfam13401 1286170006722 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 1286170006723 MT-A70; Region: MT-A70; cl01947 1286170006724 DksA-like zinc finger domain containing protein; Region: PHA00080 1286170006725 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 1286170006726 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1286170006727 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1286170006728 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1286170006729 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1286170006730 Int/Topo IB signature motif; other site 1286170006731 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1286170006732 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1286170006733 active site 1286170006734 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1286170006735 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1286170006736 putative dimer interface [polypeptide binding]; other site 1286170006737 putative anticodon binding site; other site 1286170006738 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1286170006739 homodimer interface [polypeptide binding]; other site 1286170006740 motif 1; other site 1286170006741 motif 2; other site 1286170006742 active site 1286170006743 motif 3; other site 1286170006744 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1286170006745 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1286170006746 eyelet of channel; other site 1286170006747 trimer interface [polypeptide binding]; other site 1286170006748 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1286170006749 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170006750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170006751 homodimer interface [polypeptide binding]; other site 1286170006752 catalytic residue [active] 1286170006753 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1286170006754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1286170006755 Peptidase M15; Region: Peptidase_M15_3; cl01194 1286170006756 murein L,D-transpeptidase; Provisional; Region: PRK10594 1286170006757 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286170006758 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286170006759 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286170006760 cell division protein MukB; Provisional; Region: mukB; PRK04863 1286170006761 MukB N-terminal; Region: MukB; pfam04310 1286170006762 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1286170006763 condesin subunit E; Provisional; Region: PRK05256 1286170006764 condesin subunit F; Provisional; Region: PRK05260 1286170006765 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286170006766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170006767 S-adenosylmethionine binding site [chemical binding]; other site 1286170006768 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1286170006769 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1286170006770 putative active site [active] 1286170006771 hypothetical protein; Provisional; Region: PRK10593 1286170006772 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1286170006773 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1286170006774 Ligand binding site; other site 1286170006775 oligomer interface; other site 1286170006776 Trm112p-like protein; Region: Trm112p; cl01066 1286170006777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1286170006778 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1286170006779 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1286170006780 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1286170006781 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1286170006782 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286170006783 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1286170006784 Walker A/P-loop; other site 1286170006785 ATP binding site [chemical binding]; other site 1286170006786 Q-loop/lid; other site 1286170006787 ABC transporter signature motif; other site 1286170006788 Walker B; other site 1286170006789 D-loop; other site 1286170006790 H-loop/switch region; other site 1286170006791 ComEC family competence protein; Provisional; Region: PRK11539 1286170006792 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1286170006793 Competence protein; Region: Competence; pfam03772 1286170006794 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1286170006795 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286170006796 IHF dimer interface [polypeptide binding]; other site 1286170006797 IHF - DNA interface [nucleotide binding]; other site 1286170006798 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1286170006799 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1286170006800 RNA binding site [nucleotide binding]; other site 1286170006801 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1286170006802 RNA binding site [nucleotide binding]; other site 1286170006803 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1286170006804 RNA binding site [nucleotide binding]; other site 1286170006805 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1286170006806 RNA binding site [nucleotide binding]; other site 1286170006807 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1286170006808 RNA binding site [nucleotide binding]; other site 1286170006809 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1286170006810 RNA binding site [nucleotide binding]; other site 1286170006811 cytidylate kinase; Provisional; Region: cmk; PRK00023 1286170006812 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1286170006813 CMP-binding site; other site 1286170006814 The sites determining sugar specificity; other site 1286170006815 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1286170006816 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1286170006817 hinge; other site 1286170006818 active site 1286170006819 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1286170006820 homodimer interface [polypeptide binding]; other site 1286170006821 substrate-cofactor binding pocket; other site 1286170006822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170006823 catalytic residue [active] 1286170006824 Predicted membrane protein [Function unknown]; Region: COG2323 1286170006825 uncharacterized domain; Region: TIGR00702 1286170006826 YcaO-like family; Region: YcaO; pfam02624 1286170006827 formate transporter; Provisional; Region: PRK10805 1286170006828 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1286170006829 Pyruvate formate lyase 1; Region: PFL1; cd01678 1286170006830 coenzyme A binding site [chemical binding]; other site 1286170006831 active site 1286170006832 catalytic residues [active] 1286170006833 glycine loop; other site 1286170006834 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1286170006835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170006836 FeS/SAM binding site; other site 1286170006837 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286170006838 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170006839 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170006840 putative active site [active] 1286170006841 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1286170006842 active site 1286170006843 P-loop; other site 1286170006844 phosphorylation site [posttranslational modification] 1286170006845 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1286170006846 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1286170006847 TPP-binding site [chemical binding]; other site 1286170006848 dimer interface [polypeptide binding]; other site 1286170006849 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1286170006850 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286170006851 PYR/PP interface [polypeptide binding]; other site 1286170006852 dimer interface [polypeptide binding]; other site 1286170006853 TPP binding site [chemical binding]; other site 1286170006854 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286170006855 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286170006856 active site 1286170006857 phosphorylation site [posttranslational modification] 1286170006858 putative MFS family transporter protein; Provisional; Region: PRK03633 1286170006859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170006860 putative substrate translocation pore; other site 1286170006861 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1286170006862 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1286170006863 4Fe-4S binding domain; Region: Fer4; pfam00037 1286170006864 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1286170006865 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1286170006866 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1286170006867 putative [Fe4-S4] binding site [ion binding]; other site 1286170006868 putative molybdopterin cofactor binding site [chemical binding]; other site 1286170006869 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1286170006870 putative molybdopterin cofactor binding site; other site 1286170006871 seryl-tRNA synthetase; Provisional; Region: PRK05431 1286170006872 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1286170006873 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1286170006874 dimer interface [polypeptide binding]; other site 1286170006875 active site 1286170006876 motif 1; other site 1286170006877 motif 2; other site 1286170006878 motif 3; other site 1286170006879 recombination factor protein RarA; Reviewed; Region: PRK13342 1286170006880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170006881 Walker A motif; other site 1286170006882 ATP binding site [chemical binding]; other site 1286170006883 Walker B motif; other site 1286170006884 arginine finger; other site 1286170006885 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1286170006886 periplasmic chaperone LolA; Region: lolA; TIGR00547 1286170006887 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1286170006888 DNA translocase FtsK; Provisional; Region: PRK10263 1286170006889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170006890 Sporulation related domain; Region: SPOR; cl10051 1286170006891 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1286170006892 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1286170006893 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1286170006894 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286170006895 putative DNA binding site [nucleotide binding]; other site 1286170006896 putative Zn2+ binding site [ion binding]; other site 1286170006897 AsnC family; Region: AsnC_trans_reg; pfam01037 1286170006898 thioredoxin reductase; Provisional; Region: PRK10262 1286170006899 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170006900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170006901 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1286170006902 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286170006903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170006904 Walker A/P-loop; other site 1286170006905 ATP binding site [chemical binding]; other site 1286170006906 Q-loop/lid; other site 1286170006907 ABC transporter signature motif; other site 1286170006908 Walker B; other site 1286170006909 D-loop; other site 1286170006910 H-loop/switch region; other site 1286170006911 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1286170006912 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286170006913 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1286170006914 Walker A/P-loop; other site 1286170006915 ATP binding site [chemical binding]; other site 1286170006916 Q-loop/lid; other site 1286170006917 ABC transporter signature motif; other site 1286170006918 Walker B; other site 1286170006919 D-loop; other site 1286170006920 H-loop/switch region; other site 1286170006921 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1286170006922 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1286170006923 rRNA binding site [nucleotide binding]; other site 1286170006924 predicted 30S ribosome binding site; other site 1286170006925 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1286170006926 Clp amino terminal domain; Region: Clp_N; pfam02861 1286170006927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170006928 Walker A motif; other site 1286170006929 ATP binding site [chemical binding]; other site 1286170006930 Walker B motif; other site 1286170006931 arginine finger; other site 1286170006932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170006933 Walker A motif; other site 1286170006934 ATP binding site [chemical binding]; other site 1286170006935 Walker B motif; other site 1286170006936 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1286170006937 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1286170006938 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286170006939 DNA-binding site [nucleotide binding]; DNA binding site 1286170006940 RNA-binding motif; other site 1286170006941 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1286170006942 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286170006943 Walker A/P-loop; other site 1286170006944 ATP binding site [chemical binding]; other site 1286170006945 Q-loop/lid; other site 1286170006946 ABC transporter signature motif; other site 1286170006947 Walker B; other site 1286170006948 D-loop; other site 1286170006949 H-loop/switch region; other site 1286170006950 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286170006951 FtsX-like permease family; Region: FtsX; pfam02687 1286170006952 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1286170006953 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170006954 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170006955 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1286170006956 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1286170006957 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1286170006958 putative active site [active] 1286170006959 putative metal-binding site [ion binding]; other site 1286170006960 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1286170006961 amphipathic channel; other site 1286170006962 Asn-Pro-Ala signature motifs; other site 1286170006963 Predicted membrane protein [Function unknown]; Region: COG2431 1286170006964 hybrid cluster protein; Provisional; Region: PRK05290 1286170006965 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286170006966 ACS interaction site; other site 1286170006967 CODH interaction site; other site 1286170006968 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1286170006969 hybrid metal cluster; other site 1286170006970 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1286170006971 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1286170006972 FAD binding pocket [chemical binding]; other site 1286170006973 FAD binding motif [chemical binding]; other site 1286170006974 phosphate binding motif [ion binding]; other site 1286170006975 beta-alpha-beta structure motif; other site 1286170006976 NAD binding pocket [chemical binding]; other site 1286170006977 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286170006978 catalytic loop [active] 1286170006979 iron binding site [ion binding]; other site 1286170006980 DoxX; Region: DoxX; pfam07681 1286170006981 pyruvate dehydrogenase; Provisional; Region: PRK09124 1286170006982 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1286170006983 PYR/PP interface [polypeptide binding]; other site 1286170006984 dimer interface [polypeptide binding]; other site 1286170006985 tetramer interface [polypeptide binding]; other site 1286170006986 TPP binding site [chemical binding]; other site 1286170006987 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286170006988 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1286170006989 TPP-binding site [chemical binding]; other site 1286170006990 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1286170006991 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1286170006992 tetramer interface [polypeptide binding]; other site 1286170006993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170006994 catalytic residue [active] 1286170006995 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1286170006996 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1286170006997 putative NAD(P) binding site [chemical binding]; other site 1286170006998 putative active site [active] 1286170006999 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1286170007000 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286170007001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170007002 NAD(P) binding site [chemical binding]; other site 1286170007003 active site 1286170007004 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1286170007005 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286170007006 amidase catalytic site [active] 1286170007007 Zn binding residues [ion binding]; other site 1286170007008 substrate binding site [chemical binding]; other site 1286170007009 hypothetical protein; Provisional; Region: PRK09929 1286170007010 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1286170007011 putative lipoprotein; Provisional; Region: PRK10533 1286170007012 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1286170007013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170007014 Walker A/P-loop; other site 1286170007015 ATP binding site [chemical binding]; other site 1286170007016 Q-loop/lid; other site 1286170007017 ABC transporter signature motif; other site 1286170007018 Walker B; other site 1286170007019 D-loop; other site 1286170007020 H-loop/switch region; other site 1286170007021 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1286170007022 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170007023 substrate binding pocket [chemical binding]; other site 1286170007024 membrane-bound complex binding site; other site 1286170007025 hinge residues; other site 1286170007026 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170007027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170007028 dimer interface [polypeptide binding]; other site 1286170007029 conserved gate region; other site 1286170007030 putative PBP binding loops; other site 1286170007031 ABC-ATPase subunit interface; other site 1286170007032 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170007033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170007034 dimer interface [polypeptide binding]; other site 1286170007035 conserved gate region; other site 1286170007036 putative PBP binding loops; other site 1286170007037 ABC-ATPase subunit interface; other site 1286170007038 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1286170007039 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170007040 substrate binding pocket [chemical binding]; other site 1286170007041 membrane-bound complex binding site; other site 1286170007042 hinge residues; other site 1286170007043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170007044 dimer interface [polypeptide binding]; other site 1286170007045 phosphorylation site [posttranslational modification] 1286170007046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170007047 ATP binding site [chemical binding]; other site 1286170007048 Mg2+ binding site [ion binding]; other site 1286170007049 G-X-G motif; other site 1286170007050 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286170007051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170007052 active site 1286170007053 phosphorylation site [posttranslational modification] 1286170007054 intermolecular recognition site; other site 1286170007055 dimerization interface [polypeptide binding]; other site 1286170007056 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170007057 DNA binding site [nucleotide binding] 1286170007058 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1286170007059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170007060 S-adenosylmethionine binding site [chemical binding]; other site 1286170007061 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1286170007062 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286170007063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170007064 dimer interface [polypeptide binding]; other site 1286170007065 conserved gate region; other site 1286170007066 putative PBP binding loops; other site 1286170007067 ABC-ATPase subunit interface; other site 1286170007068 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286170007069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170007070 dimer interface [polypeptide binding]; other site 1286170007071 conserved gate region; other site 1286170007072 putative PBP binding loops; other site 1286170007073 ABC-ATPase subunit interface; other site 1286170007074 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1286170007075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170007076 Walker A/P-loop; other site 1286170007077 ATP binding site [chemical binding]; other site 1286170007078 Q-loop/lid; other site 1286170007079 ABC transporter signature motif; other site 1286170007080 Walker B; other site 1286170007081 D-loop; other site 1286170007082 H-loop/switch region; other site 1286170007083 TOBE domain; Region: TOBE_2; pfam08402 1286170007084 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1286170007085 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286170007086 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1286170007087 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1286170007088 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1286170007089 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1286170007090 dimer interface [polypeptide binding]; other site 1286170007091 FMN binding site [chemical binding]; other site 1286170007092 NADPH bind site [chemical binding]; other site 1286170007093 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1286170007094 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1286170007095 GSH binding site [chemical binding]; other site 1286170007096 catalytic residues [active] 1286170007097 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1286170007098 putative transporter; Provisional; Region: PRK04972 1286170007099 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1286170007100 TrkA-C domain; Region: TrkA_C; pfam02080 1286170007101 TrkA-C domain; Region: TrkA_C; pfam02080 1286170007102 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1286170007103 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286170007104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170007105 NAD(P) binding site [chemical binding]; other site 1286170007106 active site 1286170007107 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1286170007108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170007109 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1286170007110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170007111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170007112 putative substrate translocation pore; other site 1286170007113 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1286170007114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1286170007115 active site 1286170007116 motif I; other site 1286170007117 motif II; other site 1286170007118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170007119 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1286170007120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170007121 putative substrate translocation pore; other site 1286170007122 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1286170007123 active site 1286170007124 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1286170007125 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1286170007126 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286170007127 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1286170007128 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286170007129 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1286170007130 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286170007131 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1286170007132 putative C-terminal domain interface [polypeptide binding]; other site 1286170007133 putative GSH binding site (G-site) [chemical binding]; other site 1286170007134 putative dimer interface [polypeptide binding]; other site 1286170007135 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1286170007136 N-terminal domain interface [polypeptide binding]; other site 1286170007137 dimer interface [polypeptide binding]; other site 1286170007138 substrate binding pocket (H-site) [chemical binding]; other site 1286170007139 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1286170007140 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1286170007141 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1286170007142 galactoside permease; Reviewed; Region: lacY; PRK09528 1286170007143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170007144 putative substrate translocation pore; other site 1286170007145 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1286170007146 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1286170007147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170007148 FeS/SAM binding site; other site 1286170007149 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1286170007150 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1286170007151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170007152 dimer interface [polypeptide binding]; other site 1286170007153 conserved gate region; other site 1286170007154 putative PBP binding loops; other site 1286170007155 ABC-ATPase subunit interface; other site 1286170007156 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1286170007157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170007158 dimer interface [polypeptide binding]; other site 1286170007159 conserved gate region; other site 1286170007160 putative PBP binding loops; other site 1286170007161 ABC-ATPase subunit interface; other site 1286170007162 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1286170007163 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1286170007164 potential frameshift: common BLAST hit: gi|397656909|ref|YP_006497611.1| glutathione transporter ATP-binding protein 1286170007165 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1286170007166 catalytic nucleophile [active] 1286170007167 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1286170007168 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1286170007169 dimer interface [polypeptide binding]; other site 1286170007170 putative functional site; other site 1286170007171 putative MPT binding site; other site 1286170007172 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1286170007173 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1286170007174 ATP binding site [chemical binding]; other site 1286170007175 substrate interface [chemical binding]; other site 1286170007176 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1286170007177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170007178 FeS/SAM binding site; other site 1286170007179 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1286170007180 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1286170007181 dimer interface [polypeptide binding]; other site 1286170007182 active site 1286170007183 glycine loop; other site 1286170007184 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1286170007185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170007186 active site 1286170007187 motif I; other site 1286170007188 motif II; other site 1286170007189 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170007190 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1286170007191 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170007192 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170007193 DNA binding site [nucleotide binding] 1286170007194 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1286170007195 ligand binding site [chemical binding]; other site 1286170007196 dimerization interface [polypeptide binding]; other site 1286170007197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170007198 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170007199 putative substrate translocation pore; other site 1286170007200 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1286170007201 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1286170007202 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1286170007203 putative active site [active] 1286170007204 putative catalytic site [active] 1286170007205 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1286170007206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170007207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170007208 Walker A/P-loop; other site 1286170007209 ATP binding site [chemical binding]; other site 1286170007210 ABC transporter signature motif; other site 1286170007211 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170007212 Walker B; other site 1286170007213 ABC transporter; Region: ABC_tran_2; pfam12848 1286170007214 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170007215 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1286170007216 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1286170007217 L,D-transpeptidase; Provisional; Region: PRK10260 1286170007218 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286170007219 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286170007220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170007221 DNA-binding site [nucleotide binding]; DNA binding site 1286170007222 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1286170007223 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1286170007224 beta-galactosidase; Region: BGL; TIGR03356 1286170007225 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170007226 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170007227 active site 1286170007228 catalytic tetrad [active] 1286170007229 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1286170007230 transmembrane helices; other site 1286170007231 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1286170007232 manganese transport regulator MntR; Provisional; Region: PRK11050 1286170007233 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1286170007234 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1286170007235 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1286170007236 Sulfatase; Region: Sulfatase; pfam00884 1286170007237 outer membrane protein X; Provisional; Region: ompX; PRK09408 1286170007238 threonine and homoserine efflux system; Provisional; Region: PRK10532 1286170007239 EamA-like transporter family; Region: EamA; pfam00892 1286170007240 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1286170007241 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1286170007242 dimerization interface [polypeptide binding]; other site 1286170007243 DPS ferroxidase diiron center [ion binding]; other site 1286170007244 ion pore; other site 1286170007245 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1286170007246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170007247 substrate binding pocket [chemical binding]; other site 1286170007248 membrane-bound complex binding site; other site 1286170007249 hinge residues; other site 1286170007250 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170007251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170007252 dimer interface [polypeptide binding]; other site 1286170007253 conserved gate region; other site 1286170007254 putative PBP binding loops; other site 1286170007255 ABC-ATPase subunit interface; other site 1286170007256 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1286170007257 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286170007258 Walker A/P-loop; other site 1286170007259 ATP binding site [chemical binding]; other site 1286170007260 Q-loop/lid; other site 1286170007261 ABC transporter signature motif; other site 1286170007262 Walker B; other site 1286170007263 D-loop; other site 1286170007264 H-loop/switch region; other site 1286170007265 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1286170007266 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286170007267 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1286170007268 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1286170007269 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1286170007270 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1286170007271 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 1286170007272 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170007273 N-terminal plug; other site 1286170007274 ligand-binding site [chemical binding]; other site 1286170007275 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1286170007276 hypothetical protein; Provisional; Region: PRK11019 1286170007277 hypothetical protein; Provisional; Region: PRK10259 1286170007278 glycosyl transferase family protein; Provisional; Region: PRK08136 1286170007279 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1286170007280 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1286170007281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1286170007282 DEAD_2; Region: DEAD_2; pfam06733 1286170007283 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1286170007284 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1286170007285 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1286170007286 ATP binding site [chemical binding]; other site 1286170007287 Mg++ binding site [ion binding]; other site 1286170007288 motif III; other site 1286170007289 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170007290 nucleotide binding region [chemical binding]; other site 1286170007291 ATP-binding site [chemical binding]; other site 1286170007292 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1286170007293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170007294 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1286170007295 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1286170007296 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170007297 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170007298 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286170007299 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286170007300 Walker A/P-loop; other site 1286170007301 ATP binding site [chemical binding]; other site 1286170007302 Q-loop/lid; other site 1286170007303 ABC transporter signature motif; other site 1286170007304 Walker B; other site 1286170007305 D-loop; other site 1286170007306 H-loop/switch region; other site 1286170007307 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1286170007308 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286170007309 Walker A/P-loop; other site 1286170007310 ATP binding site [chemical binding]; other site 1286170007311 Q-loop/lid; other site 1286170007312 ABC transporter signature motif; other site 1286170007313 Walker B; other site 1286170007314 D-loop; other site 1286170007315 H-loop/switch region; other site 1286170007316 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1286170007317 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1286170007318 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1286170007319 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1286170007320 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1286170007321 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1286170007322 putative catalytic site [active] 1286170007323 putative metal binding site [ion binding]; other site 1286170007324 putative phosphate binding site [ion binding]; other site 1286170007325 cardiolipin synthase 2; Provisional; Region: PRK11263 1286170007326 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1286170007327 putative active site [active] 1286170007328 catalytic site [active] 1286170007329 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1286170007330 putative active site [active] 1286170007331 catalytic site [active] 1286170007332 Predicted integral membrane protein [Function unknown]; Region: COG0392 1286170007333 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1286170007334 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1286170007335 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1286170007336 MoaE homodimer interface [polypeptide binding]; other site 1286170007337 MoaD interaction [polypeptide binding]; other site 1286170007338 active site residues [active] 1286170007339 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1286170007340 MoaE interaction surface [polypeptide binding]; other site 1286170007341 MoeB interaction surface [polypeptide binding]; other site 1286170007342 thiocarboxylated glycine; other site 1286170007343 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1286170007344 trimer interface [polypeptide binding]; other site 1286170007345 dimer interface [polypeptide binding]; other site 1286170007346 putative active site [active] 1286170007347 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1286170007348 MPT binding site; other site 1286170007349 trimer interface [polypeptide binding]; other site 1286170007350 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1286170007351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170007352 FeS/SAM binding site; other site 1286170007353 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1286170007354 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1286170007355 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1286170007356 phosphate binding site [ion binding]; other site 1286170007357 putative substrate binding pocket [chemical binding]; other site 1286170007358 dimer interface [polypeptide binding]; other site 1286170007359 putative metal dependent hydrolase; Provisional; Region: PRK11598 1286170007360 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1286170007361 Sulfatase; Region: Sulfatase; pfam00884 1286170007362 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1286170007363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170007364 active site 1286170007365 phosphorylation site [posttranslational modification] 1286170007366 intermolecular recognition site; other site 1286170007367 dimerization interface [polypeptide binding]; other site 1286170007368 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170007369 DNA binding site [nucleotide binding] 1286170007370 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1286170007371 HAMP domain; Region: HAMP; pfam00672 1286170007372 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170007373 dimer interface [polypeptide binding]; other site 1286170007374 phosphorylation site [posttranslational modification] 1286170007375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170007376 ATP binding site [chemical binding]; other site 1286170007377 Mg2+ binding site [ion binding]; other site 1286170007378 G-X-G motif; other site 1286170007379 excinuclease ABC subunit B; Provisional; Region: PRK05298 1286170007380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286170007381 ATP binding site [chemical binding]; other site 1286170007382 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170007383 nucleotide binding region [chemical binding]; other site 1286170007384 ATP-binding site [chemical binding]; other site 1286170007385 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1286170007386 UvrB/uvrC motif; Region: UVR; pfam02151 1286170007387 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1286170007388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170007389 Walker A/P-loop; other site 1286170007390 ATP binding site [chemical binding]; other site 1286170007391 Q-loop/lid; other site 1286170007392 ABC transporter signature motif; other site 1286170007393 Walker B; other site 1286170007394 D-loop; other site 1286170007395 H-loop/switch region; other site 1286170007396 AAA domain; Region: AAA_26; pfam13500 1286170007397 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1286170007398 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1286170007399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170007400 S-adenosylmethionine binding site [chemical binding]; other site 1286170007401 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1286170007402 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1286170007403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286170007404 catalytic residue [active] 1286170007405 biotin synthase; Provisional; Region: PRK15108 1286170007406 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170007407 FeS/SAM binding site; other site 1286170007408 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1286170007409 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1286170007410 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286170007411 inhibitor-cofactor binding pocket; inhibition site 1286170007412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170007413 catalytic residue [active] 1286170007414 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1286170007415 substrate binding site [chemical binding]; other site 1286170007416 putative proline-specific permease; Provisional; Region: proY; PRK10580 1286170007417 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1286170007418 active sites [active] 1286170007419 tetramer interface [polypeptide binding]; other site 1286170007420 urocanate hydratase; Provisional; Region: PRK05414 1286170007421 histidine utilization repressor; Provisional; Region: PRK14999 1286170007422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170007423 DNA-binding site [nucleotide binding]; DNA binding site 1286170007424 UTRA domain; Region: UTRA; pfam07702 1286170007425 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1286170007426 putative active site [active] 1286170007427 putative metal binding site [ion binding]; other site 1286170007428 imidazolonepropionase; Validated; Region: PRK09356 1286170007429 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1286170007430 active site 1286170007431 acyl-CoA thioesterase; Provisional; Region: PRK10531 1286170007432 putative pectinesterase; Region: PLN02432; cl01911 1286170007433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286170007434 binding surface 1286170007435 TPR motif; other site 1286170007436 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286170007437 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286170007438 DNA binding residues [nucleotide binding] 1286170007439 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1286170007440 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1286170007441 catalytic triad [active] 1286170007442 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1286170007443 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1286170007444 DsbD alpha interface [polypeptide binding]; other site 1286170007445 catalytic residues [active] 1286170007446 RNA polymerase sigma factor; Provisional; Region: PRK12512 1286170007447 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286170007448 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286170007449 DNA binding residues [nucleotide binding] 1286170007450 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 1286170007451 6-phosphogluconolactonase; Provisional; Region: PRK11028 1286170007452 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1286170007453 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1286170007454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170007455 active site 1286170007456 motif I; other site 1286170007457 motif II; other site 1286170007458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170007459 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1286170007460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170007461 Walker A/P-loop; other site 1286170007462 ATP binding site [chemical binding]; other site 1286170007463 Q-loop/lid; other site 1286170007464 ABC transporter signature motif; other site 1286170007465 Walker B; other site 1286170007466 D-loop; other site 1286170007467 H-loop/switch region; other site 1286170007468 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1286170007469 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1286170007470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170007471 dimer interface [polypeptide binding]; other site 1286170007472 conserved gate region; other site 1286170007473 putative PBP binding loops; other site 1286170007474 ABC-ATPase subunit interface; other site 1286170007475 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1286170007476 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170007477 substrate binding pocket [chemical binding]; other site 1286170007478 membrane-bound complex binding site; other site 1286170007479 hinge residues; other site 1286170007480 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1286170007481 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1286170007482 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1286170007483 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1286170007484 TOBE domain; Region: TOBE; pfam03459 1286170007485 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1286170007486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1286170007487 Walker A/P-loop; other site 1286170007488 ATP binding site [chemical binding]; other site 1286170007489 Q-loop/lid; other site 1286170007490 ABC transporter signature motif; other site 1286170007491 Walker B; other site 1286170007492 D-loop; other site 1286170007493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170007494 Walker A/P-loop; other site 1286170007495 ATP binding site [chemical binding]; other site 1286170007496 Q-loop/lid; other site 1286170007497 ABC transporter signature motif; other site 1286170007498 Walker B; other site 1286170007499 D-loop; other site 1286170007500 H-loop/switch region; other site 1286170007501 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1286170007502 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1286170007503 NAD binding site [chemical binding]; other site 1286170007504 homodimer interface [polypeptide binding]; other site 1286170007505 active site 1286170007506 substrate binding site [chemical binding]; other site 1286170007507 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1286170007508 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1286170007509 dimer interface [polypeptide binding]; other site 1286170007510 active site 1286170007511 galactokinase; Provisional; Region: PRK05101 1286170007512 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1286170007513 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1286170007514 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1286170007515 active site 1286170007516 catalytic residues [active] 1286170007517 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286170007518 catalytic core [active] 1286170007519 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286170007520 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1286170007521 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1286170007522 zinc transporter ZitB; Provisional; Region: PRK03557 1286170007523 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1286170007524 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1286170007525 quinolinate synthetase; Provisional; Region: PRK09375 1286170007526 tol-pal system protein YbgF; Provisional; Region: PRK10803 1286170007527 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1286170007528 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1286170007529 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1286170007530 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1286170007531 ligand binding site [chemical binding]; other site 1286170007532 translocation protein TolB; Provisional; Region: tolB; PRK03629 1286170007533 TolB amino-terminal domain; Region: TolB_N; pfam04052 1286170007534 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1286170007535 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1286170007536 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1286170007537 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1286170007538 TolA C-terminal; Region: TolA; pfam06519 1286170007539 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1286170007540 colicin uptake protein TolR; Provisional; Region: PRK11024 1286170007541 colicin uptake protein TolQ; Provisional; Region: PRK10801 1286170007542 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1286170007543 active site 1286170007544 hypothetical protein; Provisional; Region: PRK10588 1286170007545 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1286170007546 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1286170007547 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1286170007548 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1286170007549 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1286170007550 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1286170007551 CoA binding domain; Region: CoA_binding; smart00881 1286170007552 CoA-ligase; Region: Ligase_CoA; pfam00549 1286170007553 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1286170007554 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1286170007555 CoA-ligase; Region: Ligase_CoA; pfam00549 1286170007556 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1286170007557 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286170007558 E3 interaction surface; other site 1286170007559 lipoyl attachment site [posttranslational modification]; other site 1286170007560 e3 binding domain; Region: E3_binding; pfam02817 1286170007561 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1286170007562 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1286170007563 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1286170007564 TPP-binding site [chemical binding]; other site 1286170007565 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1286170007566 dimer interface [polypeptide binding]; other site 1286170007567 PYR/PP interface [polypeptide binding]; other site 1286170007568 TPP binding site [chemical binding]; other site 1286170007569 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1286170007570 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1286170007571 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286170007572 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1286170007573 L-aspartate oxidase; Provisional; Region: PRK06175 1286170007574 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1286170007575 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1286170007576 SdhC subunit interface [polypeptide binding]; other site 1286170007577 proximal heme binding site [chemical binding]; other site 1286170007578 cardiolipin binding site; other site 1286170007579 Iron-sulfur protein interface; other site 1286170007580 proximal quinone binding site [chemical binding]; other site 1286170007581 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1286170007582 Iron-sulfur protein interface; other site 1286170007583 proximal quinone binding site [chemical binding]; other site 1286170007584 SdhD (CybS) interface [polypeptide binding]; other site 1286170007585 proximal heme binding site [chemical binding]; other site 1286170007586 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1286170007587 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1286170007588 dimer interface [polypeptide binding]; other site 1286170007589 active site 1286170007590 citrylCoA binding site [chemical binding]; other site 1286170007591 NADH binding [chemical binding]; other site 1286170007592 cationic pore residues; other site 1286170007593 oxalacetate/citrate binding site [chemical binding]; other site 1286170007594 coenzyme A binding site [chemical binding]; other site 1286170007595 catalytic triad [active] 1286170007596 endonuclease VIII; Provisional; Region: PRK10445 1286170007597 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1286170007598 DNA binding site [nucleotide binding] 1286170007599 catalytic residue [active] 1286170007600 putative catalytic residues [active] 1286170007601 H2TH interface [polypeptide binding]; other site 1286170007602 intercalation triad [nucleotide binding]; other site 1286170007603 substrate specificity determining residue; other site 1286170007604 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1286170007605 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1286170007606 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1286170007607 putative substrate binding pocket [chemical binding]; other site 1286170007608 AC domain interface; other site 1286170007609 catalytic triad [active] 1286170007610 AB domain interface; other site 1286170007611 interchain disulfide; other site 1286170007612 Predicted membrane protein [Function unknown]; Region: COG3817 1286170007613 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1286170007614 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1286170007615 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1286170007616 putative active site [active] 1286170007617 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1286170007618 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1286170007619 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1286170007620 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1286170007621 metal-binding protein; Provisional; Region: PRK10799 1286170007622 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1286170007623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170007624 putative substrate translocation pore; other site 1286170007625 POT family; Region: PTR2; pfam00854 1286170007626 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1286170007627 DNA photolyase; Region: DNA_photolyase; pfam00875 1286170007628 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1286170007629 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1286170007630 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1286170007631 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286170007632 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1286170007633 sensor protein KdpD; Provisional; Region: PRK10490 1286170007634 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1286170007635 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1286170007636 Ligand Binding Site [chemical binding]; other site 1286170007637 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1286170007638 GAF domain; Region: GAF_3; pfam13492 1286170007639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170007640 dimer interface [polypeptide binding]; other site 1286170007641 phosphorylation site [posttranslational modification] 1286170007642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170007643 ATP binding site [chemical binding]; other site 1286170007644 Mg2+ binding site [ion binding]; other site 1286170007645 G-X-G motif; other site 1286170007646 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1286170007647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170007648 active site 1286170007649 phosphorylation site [posttranslational modification] 1286170007650 intermolecular recognition site; other site 1286170007651 dimerization interface [polypeptide binding]; other site 1286170007652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170007653 DNA binding site [nucleotide binding] 1286170007654 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1286170007655 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1286170007656 active site 1286170007657 substrate binding site [chemical binding]; other site 1286170007658 metal binding site [ion binding]; metal-binding site 1286170007659 replication initiation regulator SeqA; Provisional; Region: PRK11187 1286170007660 acyl-CoA esterase; Provisional; Region: PRK10673 1286170007661 PGAP1-like protein; Region: PGAP1; pfam07819 1286170007662 LexA regulated protein; Provisional; Region: PRK11675 1286170007663 flavodoxin FldA; Validated; Region: PRK09267 1286170007664 ferric uptake regulator; Provisional; Region: fur; PRK09462 1286170007665 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1286170007666 metal binding site 2 [ion binding]; metal-binding site 1286170007667 putative DNA binding helix; other site 1286170007668 metal binding site 1 [ion binding]; metal-binding site 1286170007669 dimer interface [polypeptide binding]; other site 1286170007670 structural Zn2+ binding site [ion binding]; other site 1286170007671 YbfN-like lipoprotein; Region: YbfN; pfam13982 1286170007672 outer membrane porin, OprD family; Region: OprD; pfam03573 1286170007673 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1286170007674 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1286170007675 active site 1286170007676 HIGH motif; other site 1286170007677 nucleotide binding site [chemical binding]; other site 1286170007678 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1286170007679 KMSKS motif; other site 1286170007680 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1286170007681 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1286170007682 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286170007683 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170007684 active site turn [active] 1286170007685 phosphorylation site [posttranslational modification] 1286170007686 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1286170007687 HPr interaction site; other site 1286170007688 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1286170007689 active site 1286170007690 phosphorylation site [posttranslational modification] 1286170007691 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1286170007692 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1286170007693 active site 1286170007694 trimer interface [polypeptide binding]; other site 1286170007695 allosteric site; other site 1286170007696 active site lid [active] 1286170007697 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1286170007698 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1286170007699 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1286170007700 active site 1286170007701 dimer interface [polypeptide binding]; other site 1286170007702 MarR family; Region: MarR; pfam01047 1286170007703 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286170007704 ROK family; Region: ROK; pfam00480 1286170007705 UMP phosphatase; Provisional; Region: PRK10444 1286170007706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170007707 active site 1286170007708 motif I; other site 1286170007709 motif II; other site 1286170007710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170007711 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1286170007712 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1286170007713 active site 1286170007714 dimer interface [polypeptide binding]; other site 1286170007715 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1286170007716 Ligand Binding Site [chemical binding]; other site 1286170007717 Molecular Tunnel; other site 1286170007718 potential protein location (hypothetical protein RORB6_11635 [Raoultella ornithinolytica B6]) that overlaps RNA (tRNA-Q) 1286170007719 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1286170007720 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286170007721 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1286170007722 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1286170007723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170007724 FeS/SAM binding site; other site 1286170007725 TRAM domain; Region: TRAM; pfam01938 1286170007726 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1286170007727 PhoH-like protein; Region: PhoH; pfam02562 1286170007728 metal-binding heat shock protein; Provisional; Region: PRK00016 1286170007729 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1286170007730 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1286170007731 Transporter associated domain; Region: CorC_HlyC; smart01091 1286170007732 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1286170007733 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1286170007734 putative active site [active] 1286170007735 catalytic triad [active] 1286170007736 putative dimer interface [polypeptide binding]; other site 1286170007737 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1286170007738 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170007739 substrate binding pocket [chemical binding]; other site 1286170007740 membrane-bound complex binding site; other site 1286170007741 hinge residues; other site 1286170007742 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170007743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170007744 dimer interface [polypeptide binding]; other site 1286170007745 conserved gate region; other site 1286170007746 putative PBP binding loops; other site 1286170007747 ABC-ATPase subunit interface; other site 1286170007748 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170007749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170007750 dimer interface [polypeptide binding]; other site 1286170007751 conserved gate region; other site 1286170007752 putative PBP binding loops; other site 1286170007753 ABC-ATPase subunit interface; other site 1286170007754 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286170007755 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286170007756 Walker A/P-loop; other site 1286170007757 ATP binding site [chemical binding]; other site 1286170007758 Q-loop/lid; other site 1286170007759 ABC transporter signature motif; other site 1286170007760 Walker B; other site 1286170007761 D-loop; other site 1286170007762 H-loop/switch region; other site 1286170007763 hypothetical protein; Provisional; Region: PRK11032 1286170007764 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1286170007765 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1286170007766 HIGH motif; other site 1286170007767 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1286170007768 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1286170007769 active site 1286170007770 KMSKS motif; other site 1286170007771 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1286170007772 tRNA binding surface [nucleotide binding]; other site 1286170007773 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1286170007774 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1286170007775 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1286170007776 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1286170007777 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1286170007778 active site 1286170007779 (T/H)XGH motif; other site 1286170007780 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286170007781 catalytic core [active] 1286170007782 ribosome-associated protein; Provisional; Region: PRK11538 1286170007783 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1286170007784 penicillin-binding protein 2; Provisional; Region: PRK10795 1286170007785 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286170007786 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286170007787 cell wall shape-determining protein; Provisional; Region: PRK10794 1286170007788 rare lipoprotein A; Provisional; Region: PRK10672 1286170007789 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1286170007790 Sporulation related domain; Region: SPOR; pfam05036 1286170007791 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1286170007792 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286170007793 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1286170007794 hypothetical protein; Provisional; Region: PRK04998 1286170007795 lipoate-protein ligase B; Provisional; Region: PRK14342 1286170007796 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1286170007797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170007798 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1286170007799 substrate binding pocket [chemical binding]; other site 1286170007800 dimerization interface [polypeptide binding]; other site 1286170007801 lipoyl synthase; Provisional; Region: PRK05481 1286170007802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170007803 FeS/SAM binding site; other site 1286170007804 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1286170007805 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1286170007806 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1286170007807 putative active site [active] 1286170007808 catalytic triad [active] 1286170007809 putative dimer interface [polypeptide binding]; other site 1286170007810 chromosome condensation membrane protein; Provisional; Region: PRK14196 1286170007811 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286170007812 DNA-binding site [nucleotide binding]; DNA binding site 1286170007813 RNA-binding motif; other site 1286170007814 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1286170007815 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1286170007816 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1286170007817 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1286170007818 B1 nucleotide binding pocket [chemical binding]; other site 1286170007819 B2 nucleotide binding pocket [chemical binding]; other site 1286170007820 CAS motifs; other site 1286170007821 active site 1286170007822 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286170007823 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286170007824 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286170007825 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1286170007826 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1286170007827 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286170007828 Ligand Binding Site [chemical binding]; other site 1286170007829 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1286170007830 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1286170007831 catalytic residue [active] 1286170007832 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1286170007833 catalytic residues [active] 1286170007834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170007835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170007836 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1286170007837 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1286170007838 dimer interface [polypeptide binding]; other site 1286170007839 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1286170007840 catalytic triad [active] 1286170007841 peroxidatic and resolving cysteines [active] 1286170007842 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1286170007843 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1286170007844 dimerization domain [polypeptide binding]; other site 1286170007845 dimer interface [polypeptide binding]; other site 1286170007846 catalytic residues [active] 1286170007847 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1286170007848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170007849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170007850 dimerization interface [polypeptide binding]; other site 1286170007851 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1286170007852 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1286170007853 Active Sites [active] 1286170007854 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1286170007855 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1286170007856 ParB-like nuclease domain; Region: ParBc; pfam02195 1286170007857 methionine aminotransferase; Validated; Region: PRK09082 1286170007858 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170007859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170007860 homodimer interface [polypeptide binding]; other site 1286170007861 catalytic residue [active] 1286170007862 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 1286170007863 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170007864 motif II; other site 1286170007865 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1286170007866 Cupin domain; Region: Cupin_2; cl17218 1286170007867 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1286170007868 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1286170007869 molybdopterin cofactor binding site [chemical binding]; other site 1286170007870 substrate binding site [chemical binding]; other site 1286170007871 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1286170007872 molybdopterin cofactor binding site; other site 1286170007873 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1286170007874 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286170007875 putative ligand binding site [chemical binding]; other site 1286170007876 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286170007877 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170007878 Walker A/P-loop; other site 1286170007879 ATP binding site [chemical binding]; other site 1286170007880 Q-loop/lid; other site 1286170007881 ABC transporter signature motif; other site 1286170007882 Walker B; other site 1286170007883 D-loop; other site 1286170007884 H-loop/switch region; other site 1286170007885 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170007886 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170007887 TM-ABC transporter signature motif; other site 1286170007888 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170007889 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170007890 TM-ABC transporter signature motif; other site 1286170007891 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170007892 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1286170007893 substrate binding site [chemical binding]; other site 1286170007894 ATP binding site [chemical binding]; other site 1286170007895 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1286170007896 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1286170007897 putative ligand binding site [chemical binding]; other site 1286170007898 putative NAD binding site [chemical binding]; other site 1286170007899 catalytic site [active] 1286170007900 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1286170007901 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1286170007902 putative N- and C-terminal domain interface [polypeptide binding]; other site 1286170007903 putative active site [active] 1286170007904 MgATP binding site [chemical binding]; other site 1286170007905 catalytic site [active] 1286170007906 metal binding site [ion binding]; metal-binding site 1286170007907 putative xylulose binding site [chemical binding]; other site 1286170007908 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1286170007909 intersubunit interface [polypeptide binding]; other site 1286170007910 active site 1286170007911 Zn2+ binding site [ion binding]; other site 1286170007912 cytosine permease; Provisional; Region: codB; PRK11017 1286170007913 Na binding site [ion binding]; other site 1286170007914 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1286170007915 DRTGG domain; Region: DRTGG; pfam07085 1286170007916 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1286170007917 cytosine deaminase; Provisional; Region: PRK09230 1286170007918 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1286170007919 active site 1286170007920 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170007921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170007922 DNA binding site [nucleotide binding] 1286170007923 domain linker motif; other site 1286170007924 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1286170007925 putative dimerization interface [polypeptide binding]; other site 1286170007926 putative ligand binding site [chemical binding]; other site 1286170007927 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286170007928 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1286170007929 active site 1286170007930 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1286170007931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170007932 putative substrate translocation pore; other site 1286170007933 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1286170007934 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1286170007935 catalytic core [active] 1286170007936 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1286170007937 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1286170007938 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1286170007939 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1286170007940 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1286170007941 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1286170007942 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286170007943 putative ligand binding site [chemical binding]; other site 1286170007944 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170007945 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170007946 TM-ABC transporter signature motif; other site 1286170007947 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286170007948 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170007949 Walker A/P-loop; other site 1286170007950 ATP binding site [chemical binding]; other site 1286170007951 Q-loop/lid; other site 1286170007952 ABC transporter signature motif; other site 1286170007953 Walker B; other site 1286170007954 D-loop; other site 1286170007955 H-loop/switch region; other site 1286170007956 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170007957 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1286170007958 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1286170007959 putative active site [active] 1286170007960 metal binding site [ion binding]; metal-binding site 1286170007961 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1286170007962 classical (c) SDRs; Region: SDR_c; cd05233 1286170007963 NAD(P) binding site [chemical binding]; other site 1286170007964 active site 1286170007965 Uncharacterized small protein [Function unknown]; Region: COG2879 1286170007966 carbon starvation protein A; Provisional; Region: PRK15015 1286170007967 Carbon starvation protein CstA; Region: CstA; pfam02554 1286170007968 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1286170007969 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1286170007970 CoenzymeA binding site [chemical binding]; other site 1286170007971 subunit interaction site [polypeptide binding]; other site 1286170007972 PHB binding site; other site 1286170007973 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1286170007974 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1286170007975 putative NAD(P) binding site [chemical binding]; other site 1286170007976 active site 1286170007977 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1286170007978 hydrophobic substrate binding pocket; other site 1286170007979 Isochorismatase family; Region: Isochorismatase; pfam00857 1286170007980 active site 1286170007981 conserved cis-peptide bond; other site 1286170007982 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1286170007983 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1286170007984 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1286170007985 acyl-activating enzyme (AAE) consensus motif; other site 1286170007986 active site 1286170007987 AMP binding site [chemical binding]; other site 1286170007988 substrate binding site [chemical binding]; other site 1286170007989 isochorismate synthase EntC; Provisional; Region: PRK15016 1286170007990 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1286170007991 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1286170007992 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1286170007993 siderophore binding site; other site 1286170007994 enterobactin exporter EntS; Provisional; Region: PRK10489 1286170007995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170007996 putative substrate translocation pore; other site 1286170007997 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286170007998 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1286170007999 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170008000 ABC-ATPase subunit interface; other site 1286170008001 dimer interface [polypeptide binding]; other site 1286170008002 putative PBP binding regions; other site 1286170008003 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1286170008004 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170008005 ABC-ATPase subunit interface; other site 1286170008006 dimer interface [polypeptide binding]; other site 1286170008007 putative PBP binding regions; other site 1286170008008 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1286170008009 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286170008010 Walker A/P-loop; other site 1286170008011 ATP binding site [chemical binding]; other site 1286170008012 Q-loop/lid; other site 1286170008013 ABC transporter signature motif; other site 1286170008014 Walker B; other site 1286170008015 D-loop; other site 1286170008016 H-loop/switch region; other site 1286170008017 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 1286170008018 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1286170008019 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286170008020 acyl-activating enzyme (AAE) consensus motif; other site 1286170008021 AMP binding site [chemical binding]; other site 1286170008022 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286170008023 MbtH-like protein; Region: MbtH; cl01279 1286170008024 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1286170008025 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1286170008026 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1286170008027 outer membrane receptor FepA; Provisional; Region: PRK13524 1286170008028 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170008029 N-terminal plug; other site 1286170008030 ligand-binding site [chemical binding]; other site 1286170008031 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1286170008032 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1286170008033 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1286170008034 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286170008035 PYR/PP interface [polypeptide binding]; other site 1286170008036 dimer interface [polypeptide binding]; other site 1286170008037 TPP binding site [chemical binding]; other site 1286170008038 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286170008039 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1286170008040 TPP-binding site [chemical binding]; other site 1286170008041 dimer interface [polypeptide binding]; other site 1286170008042 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286170008043 MarR family; Region: MarR_2; cl17246 1286170008044 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286170008045 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 1286170008046 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1286170008047 N- and C-terminal domain interface [polypeptide binding]; other site 1286170008048 active site 1286170008049 MgATP binding site [chemical binding]; other site 1286170008050 catalytic site [active] 1286170008051 metal binding site [ion binding]; metal-binding site 1286170008052 putative homotetramer interface [polypeptide binding]; other site 1286170008053 putative homodimer interface [polypeptide binding]; other site 1286170008054 glycerol binding site [chemical binding]; other site 1286170008055 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1286170008056 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286170008057 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 1286170008058 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286170008059 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170008060 Walker A/P-loop; other site 1286170008061 ATP binding site [chemical binding]; other site 1286170008062 Q-loop/lid; other site 1286170008063 ABC transporter signature motif; other site 1286170008064 Walker B; other site 1286170008065 D-loop; other site 1286170008066 H-loop/switch region; other site 1286170008067 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170008068 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170008069 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170008070 TM-ABC transporter signature motif; other site 1286170008071 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286170008072 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1286170008073 NAD binding site [chemical binding]; other site 1286170008074 homotetramer interface [polypeptide binding]; other site 1286170008075 homodimer interface [polypeptide binding]; other site 1286170008076 active site 1286170008077 substrate binding site [chemical binding]; other site 1286170008078 short chain dehydrogenase; Provisional; Region: PRK06114 1286170008079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170008080 NAD(P) binding site [chemical binding]; other site 1286170008081 active site 1286170008082 choline transport protein BetT; Provisional; Region: PRK09928 1286170008083 transcriptional regulator BetI; Validated; Region: PRK00767 1286170008084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170008085 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1286170008086 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1286170008087 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1286170008088 tetrameric interface [polypeptide binding]; other site 1286170008089 NAD binding site [chemical binding]; other site 1286170008090 catalytic residues [active] 1286170008091 choline dehydrogenase; Validated; Region: PRK02106 1286170008092 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1286170008093 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286170008094 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286170008095 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286170008096 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1286170008097 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286170008098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170008099 dimer interface [polypeptide binding]; other site 1286170008100 conserved gate region; other site 1286170008101 putative PBP binding loops; other site 1286170008102 ABC-ATPase subunit interface; other site 1286170008103 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1286170008104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170008105 dimer interface [polypeptide binding]; other site 1286170008106 conserved gate region; other site 1286170008107 ABC-ATPase subunit interface; other site 1286170008108 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1286170008109 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170008110 Walker A/P-loop; other site 1286170008111 ATP binding site [chemical binding]; other site 1286170008112 Q-loop/lid; other site 1286170008113 ABC transporter signature motif; other site 1286170008114 Walker B; other site 1286170008115 D-loop; other site 1286170008116 H-loop/switch region; other site 1286170008117 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170008118 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1286170008119 Walker A/P-loop; other site 1286170008120 ATP binding site [chemical binding]; other site 1286170008121 Q-loop/lid; other site 1286170008122 ABC transporter signature motif; other site 1286170008123 Walker B; other site 1286170008124 D-loop; other site 1286170008125 H-loop/switch region; other site 1286170008126 hypothetical protein; Provisional; Region: PRK06062 1286170008127 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286170008128 inhibitor-cofactor binding pocket; inhibition site 1286170008129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170008130 catalytic residue [active] 1286170008131 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1286170008132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170008133 NAD(P) binding site [chemical binding]; other site 1286170008134 active site 1286170008135 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286170008136 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286170008137 Walker A/P-loop; other site 1286170008138 ATP binding site [chemical binding]; other site 1286170008139 Q-loop/lid; other site 1286170008140 ABC transporter signature motif; other site 1286170008141 Walker B; other site 1286170008142 D-loop; other site 1286170008143 H-loop/switch region; other site 1286170008144 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170008145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170008146 dimer interface [polypeptide binding]; other site 1286170008147 conserved gate region; other site 1286170008148 putative PBP binding loops; other site 1286170008149 ABC-ATPase subunit interface; other site 1286170008150 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170008151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170008152 dimer interface [polypeptide binding]; other site 1286170008153 conserved gate region; other site 1286170008154 putative PBP binding loops; other site 1286170008155 ABC-ATPase subunit interface; other site 1286170008156 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170008157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170008158 substrate binding pocket [chemical binding]; other site 1286170008159 membrane-bound complex binding site; other site 1286170008160 hinge residues; other site 1286170008161 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286170008162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170008163 DNA-binding site [nucleotide binding]; DNA binding site 1286170008164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170008165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170008166 homodimer interface [polypeptide binding]; other site 1286170008167 catalytic residue [active] 1286170008168 allantoate amidohydrolase; Reviewed; Region: PRK12893 1286170008169 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1286170008170 active site 1286170008171 metal binding site [ion binding]; metal-binding site 1286170008172 dimer interface [polypeptide binding]; other site 1286170008173 amidase; Provisional; Region: PRK08310 1286170008174 indole-3-acetamide amidohydrolase; Region: PLN02722 1286170008175 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286170008176 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170008177 Walker A/P-loop; other site 1286170008178 ATP binding site [chemical binding]; other site 1286170008179 Q-loop/lid; other site 1286170008180 ABC transporter signature motif; other site 1286170008181 Walker B; other site 1286170008182 D-loop; other site 1286170008183 H-loop/switch region; other site 1286170008184 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286170008185 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1286170008186 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170008187 Walker A/P-loop; other site 1286170008188 ATP binding site [chemical binding]; other site 1286170008189 Q-loop/lid; other site 1286170008190 ABC transporter signature motif; other site 1286170008191 Walker B; other site 1286170008192 D-loop; other site 1286170008193 H-loop/switch region; other site 1286170008194 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286170008195 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286170008196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170008197 dimer interface [polypeptide binding]; other site 1286170008198 ABC-ATPase subunit interface; other site 1286170008199 putative PBP binding loops; other site 1286170008200 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286170008201 Protein of unknown function (DUF419); Region: DUF419; cl15265 1286170008202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170008203 dimer interface [polypeptide binding]; other site 1286170008204 conserved gate region; other site 1286170008205 putative PBP binding loops; other site 1286170008206 ABC-ATPase subunit interface; other site 1286170008207 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 1286170008208 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1286170008209 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1286170008210 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1286170008211 Predicted periplasmic protein [Function unknown]; Region: COG3698 1286170008212 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1286170008213 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286170008214 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286170008215 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170008216 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170008217 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1286170008218 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1286170008219 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286170008220 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1286170008221 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1286170008222 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1286170008223 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1286170008224 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1286170008225 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1286170008226 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1286170008227 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1286170008228 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1286170008229 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170008230 N-terminal plug; other site 1286170008231 ligand-binding site [chemical binding]; other site 1286170008232 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1286170008233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170008234 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1286170008235 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1286170008236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286170008237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170008238 hypothetical protein; Provisional; Region: PRK10250 1286170008239 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1286170008240 dimer interface [polypeptide binding]; other site 1286170008241 FMN binding site [chemical binding]; other site 1286170008242 Helix-turn-helix domain; Region: HTH_31; pfam13560 1286170008243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170008244 putative substrate translocation pore; other site 1286170008245 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1286170008246 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286170008247 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170008248 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170008249 DNA binding site [nucleotide binding] 1286170008250 domain linker motif; other site 1286170008251 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1286170008252 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286170008253 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286170008254 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286170008255 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286170008256 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1286170008257 Metal-binding active site; metal-binding site 1286170008258 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1286170008259 nucleoside transporter; Region: 2A0110; TIGR00889 1286170008260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170008261 putative substrate translocation pore; other site 1286170008262 phenylalanine transporter; Provisional; Region: PRK10249 1286170008263 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1286170008264 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170008265 N-terminal plug; other site 1286170008266 ligand-binding site [chemical binding]; other site 1286170008267 PQQ-like domain; Region: PQQ_2; pfam13360 1286170008268 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1286170008269 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1286170008270 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286170008271 NAD(P) binding site [chemical binding]; other site 1286170008272 catalytic residues [active] 1286170008273 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286170008274 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286170008275 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1286170008276 Amino acid permease; Region: AA_permease_2; pfam13520 1286170008277 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1286170008278 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 1286170008279 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1286170008280 active site 1286170008281 Zn binding site [ion binding]; other site 1286170008282 benzoate transport; Region: 2A0115; TIGR00895 1286170008283 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286170008284 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170008285 DNA binding residues [nucleotide binding] 1286170008286 dimerization interface [polypeptide binding]; other site 1286170008287 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1286170008288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170008289 FeS/SAM binding site; other site 1286170008290 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1286170008291 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1286170008292 Sulfatase; Region: Sulfatase; pfam00884 1286170008293 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 1286170008294 classical (c) SDRs; Region: SDR_c; cd05233 1286170008295 NAD(P) binding site [chemical binding]; other site 1286170008296 active site 1286170008297 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1286170008298 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170008299 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170008300 active site 1286170008301 catalytic tetrad [active] 1286170008302 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1286170008303 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170008304 substrate binding pocket [chemical binding]; other site 1286170008305 membrane-bound complex binding site; other site 1286170008306 hinge residues; other site 1286170008307 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286170008308 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1286170008309 metal binding site [ion binding]; metal-binding site 1286170008310 putative dimer interface [polypeptide binding]; other site 1286170008311 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 1286170008312 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1286170008313 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1286170008314 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1286170008315 intersubunit interface [polypeptide binding]; other site 1286170008316 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286170008317 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170008318 dimer interface [polypeptide binding]; other site 1286170008319 putative PBP binding regions; other site 1286170008320 ABC-ATPase subunit interface; other site 1286170008321 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1286170008322 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286170008323 Walker A/P-loop; other site 1286170008324 ATP binding site [chemical binding]; other site 1286170008325 Q-loop/lid; other site 1286170008326 ABC transporter signature motif; other site 1286170008327 Walker B; other site 1286170008328 D-loop; other site 1286170008329 H-loop/switch region; other site 1286170008330 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1286170008331 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170008332 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170008333 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1286170008334 Transcriptional regulator; Region: Rrf2; cl17282 1286170008335 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170008336 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1286170008337 putative substrate binding site [chemical binding]; other site 1286170008338 putative ATP binding site [chemical binding]; other site 1286170008339 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1286170008340 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1286170008341 trimer interface; other site 1286170008342 sugar binding site [chemical binding]; other site 1286170008343 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1286170008344 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170008345 active site turn [active] 1286170008346 phosphorylation site [posttranslational modification] 1286170008347 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286170008348 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1286170008349 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1286170008350 substrate binding [chemical binding]; other site 1286170008351 active site 1286170008352 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1286170008353 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1286170008354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170008355 DNA binding site [nucleotide binding] 1286170008356 domain linker motif; other site 1286170008357 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1286170008358 dimerization interface [polypeptide binding]; other site 1286170008359 ligand binding site [chemical binding]; other site 1286170008360 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1286170008361 CAT RNA binding domain; Region: CAT_RBD; smart01061 1286170008362 PRD domain; Region: PRD; pfam00874 1286170008363 PRD domain; Region: PRD; pfam00874 1286170008364 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1286170008365 beta-galactosidase; Region: BGL; TIGR03356 1286170008366 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1286170008367 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170008368 active site turn [active] 1286170008369 phosphorylation site [posttranslational modification] 1286170008370 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286170008371 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1286170008372 HPr interaction site; other site 1286170008373 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1286170008374 active site 1286170008375 phosphorylation site [posttranslational modification] 1286170008376 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286170008377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170008378 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1286170008379 dimerization interface [polypeptide binding]; other site 1286170008380 substrate binding pocket [chemical binding]; other site 1286170008381 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1286170008382 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170008383 TM-ABC transporter signature motif; other site 1286170008384 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1286170008385 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1286170008386 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1286170008387 TM-ABC transporter signature motif; other site 1286170008388 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286170008389 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1286170008390 Walker A/P-loop; other site 1286170008391 ATP binding site [chemical binding]; other site 1286170008392 Q-loop/lid; other site 1286170008393 ABC transporter signature motif; other site 1286170008394 Walker B; other site 1286170008395 D-loop; other site 1286170008396 H-loop/switch region; other site 1286170008397 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1286170008398 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1286170008399 Walker A/P-loop; other site 1286170008400 ATP binding site [chemical binding]; other site 1286170008401 Q-loop/lid; other site 1286170008402 ABC transporter signature motif; other site 1286170008403 Walker B; other site 1286170008404 D-loop; other site 1286170008405 H-loop/switch region; other site 1286170008406 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1286170008407 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1286170008408 dimerization interface [polypeptide binding]; other site 1286170008409 ligand binding site [chemical binding]; other site 1286170008410 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1286170008411 allantoate amidohydrolase; Reviewed; Region: PRK12893 1286170008412 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1286170008413 active site 1286170008414 metal binding site [ion binding]; metal-binding site 1286170008415 dimer interface [polypeptide binding]; other site 1286170008416 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170008417 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170008418 metal binding site [ion binding]; metal-binding site 1286170008419 active site 1286170008420 I-site; other site 1286170008421 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170008422 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170008423 TM-ABC transporter signature motif; other site 1286170008424 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286170008425 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170008426 Walker A/P-loop; other site 1286170008427 ATP binding site [chemical binding]; other site 1286170008428 Q-loop/lid; other site 1286170008429 ABC transporter signature motif; other site 1286170008430 Walker B; other site 1286170008431 D-loop; other site 1286170008432 H-loop/switch region; other site 1286170008433 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170008434 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286170008435 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1286170008436 putative ligand binding site [chemical binding]; other site 1286170008437 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 1286170008438 PLD-like domain; Region: PLDc_2; pfam13091 1286170008439 putative active site [active] 1286170008440 catalytic site [active] 1286170008441 potential frameshift: common BLAST hit: gi|444352713|ref|YP_007388857.1| Putative HTH-type transcriptional regulator yahB 1286170008442 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1286170008443 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1286170008444 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1286170008445 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1286170008446 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1286170008447 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1286170008448 CoA binding domain; Region: CoA_binding; pfam02629 1286170008449 CoA-ligase; Region: Ligase_CoA; pfam00549 1286170008450 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1286170008451 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1286170008452 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1286170008453 putative substrate binding site [chemical binding]; other site 1286170008454 nucleotide binding site [chemical binding]; other site 1286170008455 nucleotide binding site [chemical binding]; other site 1286170008456 homodimer interface [polypeptide binding]; other site 1286170008457 putative deaminase; Validated; Region: PRK06846 1286170008458 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1286170008459 active site 1286170008460 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1286170008461 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1286170008462 dimer interface [polypeptide binding]; other site 1286170008463 putative anticodon binding site; other site 1286170008464 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1286170008465 motif 1; other site 1286170008466 active site 1286170008467 motif 2; other site 1286170008468 motif 3; other site 1286170008469 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1286170008470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170008471 putative substrate translocation pore; other site 1286170008472 POT family; Region: PTR2; pfam00854 1286170008473 lysine decarboxylase CadA; Provisional; Region: PRK15400 1286170008474 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1286170008475 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1286170008476 homodimer interface [polypeptide binding]; other site 1286170008477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170008478 catalytic residue [active] 1286170008479 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1286170008480 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1286170008481 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1286170008482 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1286170008483 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170008484 DNA binding site [nucleotide binding] 1286170008485 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1286170008486 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1286170008487 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1286170008488 trimer interface [polypeptide binding]; other site 1286170008489 active site 1286170008490 substrate binding site [chemical binding]; other site 1286170008491 CoA binding site [chemical binding]; other site 1286170008492 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1286170008493 Spore germination protein; Region: Spore_permease; cl17796 1286170008494 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1286170008495 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170008496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170008497 homodimer interface [polypeptide binding]; other site 1286170008498 catalytic residue [active] 1286170008499 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286170008500 homotrimer interaction site [polypeptide binding]; other site 1286170008501 putative active site [active] 1286170008502 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286170008503 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286170008504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170008505 Coenzyme A binding pocket [chemical binding]; other site 1286170008506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286170008507 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1286170008508 dimer interface [polypeptide binding]; other site 1286170008509 Citrate synthase; Region: Citrate_synt; pfam00285 1286170008510 active site 1286170008511 citrylCoA binding site [chemical binding]; other site 1286170008512 NADH binding [chemical binding]; other site 1286170008513 cationic pore residues; other site 1286170008514 oxalacetate/citrate binding site [chemical binding]; other site 1286170008515 coenzyme A binding site [chemical binding]; other site 1286170008516 catalytic triad [active] 1286170008517 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1286170008518 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 1286170008519 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1286170008520 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1286170008521 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1286170008522 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1286170008523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170008524 S-adenosylmethionine binding site [chemical binding]; other site 1286170008525 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1286170008526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286170008527 dimerization interface [polypeptide binding]; other site 1286170008528 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170008529 dimer interface [polypeptide binding]; other site 1286170008530 phosphorylation site [posttranslational modification] 1286170008531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170008532 ATP binding site [chemical binding]; other site 1286170008533 Mg2+ binding site [ion binding]; other site 1286170008534 G-X-G motif; other site 1286170008535 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1286170008536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170008537 active site 1286170008538 phosphorylation site [posttranslational modification] 1286170008539 intermolecular recognition site; other site 1286170008540 dimerization interface [polypeptide binding]; other site 1286170008541 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170008542 DNA binding site [nucleotide binding] 1286170008543 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286170008544 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286170008545 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170008546 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170008547 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1286170008548 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1286170008549 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1286170008550 homodimer interface [polypeptide binding]; other site 1286170008551 NADP binding site [chemical binding]; other site 1286170008552 substrate binding site [chemical binding]; other site 1286170008553 ribosome-associated protein; Provisional; Region: PRK11507 1286170008554 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1286170008555 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1286170008556 active site 1286170008557 HIGH motif; other site 1286170008558 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1286170008559 KMSKS motif; other site 1286170008560 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1286170008561 tRNA binding surface [nucleotide binding]; other site 1286170008562 anticodon binding site; other site 1286170008563 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1286170008564 substrate binding site [chemical binding]; other site 1286170008565 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1286170008566 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286170008567 putative active site [active] 1286170008568 putative metal binding site [ion binding]; other site 1286170008569 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1286170008570 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1286170008571 ATP-grasp domain; Region: ATP-grasp; pfam02222 1286170008572 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1286170008573 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1286170008574 active site residue [active] 1286170008575 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1286170008576 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1286170008577 putative monooxygenase; Provisional; Region: PRK11118 1286170008578 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1286170008579 FtsX-like permease family; Region: FtsX; pfam02687 1286170008580 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1286170008581 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286170008582 Walker A/P-loop; other site 1286170008583 ATP binding site [chemical binding]; other site 1286170008584 Q-loop/lid; other site 1286170008585 ABC transporter signature motif; other site 1286170008586 Walker B; other site 1286170008587 D-loop; other site 1286170008588 H-loop/switch region; other site 1286170008589 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1286170008590 active site 1286170008591 catalytic triad [active] 1286170008592 oxyanion hole [active] 1286170008593 switch loop; other site 1286170008594 oxidoreductase; Provisional; Region: PRK08017 1286170008595 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1286170008596 NADP binding site [chemical binding]; other site 1286170008597 active site 1286170008598 steroid binding site; other site 1286170008599 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1286170008600 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1286170008601 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1286170008602 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1286170008603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170008604 Walker A/P-loop; other site 1286170008605 ATP binding site [chemical binding]; other site 1286170008606 Q-loop/lid; other site 1286170008607 ABC transporter signature motif; other site 1286170008608 Walker B; other site 1286170008609 D-loop; other site 1286170008610 H-loop/switch region; other site 1286170008611 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1286170008612 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1286170008613 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1286170008614 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1286170008615 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1286170008616 DNA binding residues [nucleotide binding] 1286170008617 dimer interface [polypeptide binding]; other site 1286170008618 copper binding site [ion binding]; other site 1286170008619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170008620 metabolite-proton symporter; Region: 2A0106; TIGR00883 1286170008621 putative substrate translocation pore; other site 1286170008622 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170008623 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170008624 DNA binding site [nucleotide binding] 1286170008625 domain linker motif; other site 1286170008626 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1286170008627 dimerization interface [polypeptide binding]; other site 1286170008628 ligand binding site [chemical binding]; other site 1286170008629 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1286170008630 active site 1286170008631 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1286170008632 MgtC family; Region: MgtC; pfam02308 1286170008633 copper exporting ATPase; Provisional; Region: copA; PRK10671 1286170008634 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286170008635 metal-binding site [ion binding] 1286170008636 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286170008637 metal-binding site [ion binding] 1286170008638 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286170008639 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170008640 motif II; other site 1286170008641 TraB family; Region: TraB; cl12050 1286170008642 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1286170008643 putative deacylase active site [active] 1286170008644 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1286170008645 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1286170008646 active site 1286170008647 metal binding site [ion binding]; metal-binding site 1286170008648 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1286170008649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170008650 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170008651 putative substrate translocation pore; other site 1286170008652 putative cation:proton antiport protein; Provisional; Region: PRK10669 1286170008653 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1286170008654 TrkA-N domain; Region: TrkA_N; pfam02254 1286170008655 inosine/guanosine kinase; Provisional; Region: PRK15074 1286170008656 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170008657 ferrochelatase; Reviewed; Region: hemH; PRK00035 1286170008658 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1286170008659 C-terminal domain interface [polypeptide binding]; other site 1286170008660 active site 1286170008661 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1286170008662 active site 1286170008663 N-terminal domain interface [polypeptide binding]; other site 1286170008664 adenylate kinase; Reviewed; Region: adk; PRK00279 1286170008665 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1286170008666 AMP-binding site [chemical binding]; other site 1286170008667 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1286170008668 heat shock protein 90; Provisional; Region: PRK05218 1286170008669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170008670 ATP binding site [chemical binding]; other site 1286170008671 Mg2+ binding site [ion binding]; other site 1286170008672 G-X-G motif; other site 1286170008673 recombination protein RecR; Reviewed; Region: recR; PRK00076 1286170008674 RecR protein; Region: RecR; pfam02132 1286170008675 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1286170008676 putative active site [active] 1286170008677 putative metal-binding site [ion binding]; other site 1286170008678 tetramer interface [polypeptide binding]; other site 1286170008679 hypothetical protein; Validated; Region: PRK00153 1286170008680 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1286170008681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170008682 Walker A motif; other site 1286170008683 ATP binding site [chemical binding]; other site 1286170008684 Walker B motif; other site 1286170008685 arginine finger; other site 1286170008686 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1286170008687 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1286170008688 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1286170008689 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286170008690 active site 1286170008691 hypothetical protein; Provisional; Region: PRK10527 1286170008692 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 1286170008693 hypothetical protein; Provisional; Region: PRK11038 1286170008694 hypothetical protein; Provisional; Region: PRK11281 1286170008695 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1286170008696 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1286170008697 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286170008698 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1286170008699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170008700 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1286170008701 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1286170008702 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170008703 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1286170008704 Protein export membrane protein; Region: SecD_SecF; cl14618 1286170008705 Protein export membrane protein; Region: SecD_SecF; cl14618 1286170008706 Hha toxicity attenuator; Provisional; Region: PRK10667 1286170008707 gene expression modulator; Provisional; Region: PRK10945 1286170008708 maltose O-acetyltransferase; Provisional; Region: PRK10092 1286170008709 Maltose acetyltransferase; Region: Mac; pfam12464 1286170008710 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1286170008711 trimer interface [polypeptide binding]; other site 1286170008712 active site 1286170008713 substrate binding site [chemical binding]; other site 1286170008714 CoA binding site [chemical binding]; other site 1286170008715 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1286170008716 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286170008717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170008718 DNA-binding site [nucleotide binding]; DNA binding site 1286170008719 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170008720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170008721 homodimer interface [polypeptide binding]; other site 1286170008722 catalytic residue [active] 1286170008723 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286170008724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286170008725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286170008726 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1286170008727 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1286170008728 lac repressor; Reviewed; Region: lacI; PRK09526 1286170008729 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170008730 DNA binding site [nucleotide binding] 1286170008731 domain linker motif; other site 1286170008732 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1286170008733 ligand binding site [chemical binding]; other site 1286170008734 dimerization interface (open form) [polypeptide binding]; other site 1286170008735 dimerization interface (closed form) [polypeptide binding]; other site 1286170008736 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1286170008737 trimer interface; other site 1286170008738 sugar binding site [chemical binding]; other site 1286170008739 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170008740 active site turn [active] 1286170008741 phosphorylation site [posttranslational modification] 1286170008742 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1286170008743 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1286170008744 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1286170008745 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1286170008746 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 1286170008747 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286170008748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170008749 dimer interface [polypeptide binding]; other site 1286170008750 conserved gate region; other site 1286170008751 putative PBP binding loops; other site 1286170008752 ABC-ATPase subunit interface; other site 1286170008753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170008754 dimer interface [polypeptide binding]; other site 1286170008755 conserved gate region; other site 1286170008756 ABC-ATPase subunit interface; other site 1286170008757 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1286170008758 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286170008759 DAK2 domain; Region: Dak2; cl03685 1286170008760 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286170008761 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286170008762 Walker A/P-loop; other site 1286170008763 ATP binding site [chemical binding]; other site 1286170008764 Q-loop/lid; other site 1286170008765 ABC transporter signature motif; other site 1286170008766 Walker B; other site 1286170008767 D-loop; other site 1286170008768 H-loop/switch region; other site 1286170008769 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1286170008770 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1286170008771 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170008772 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1286170008773 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 1286170008774 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286170008775 Predicted membrane protein [Function unknown]; Region: COG2364 1286170008776 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286170008777 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170008778 DNA-binding site [nucleotide binding]; DNA binding site 1286170008779 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286170008780 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170008781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170008782 homodimer interface [polypeptide binding]; other site 1286170008783 catalytic residue [active] 1286170008784 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1286170008785 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1286170008786 DNA binding site [nucleotide binding] 1286170008787 active site 1286170008788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1286170008789 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1286170008790 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1286170008791 active site 1286170008792 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1286170008793 catalytic triad [active] 1286170008794 dimer interface [polypeptide binding]; other site 1286170008795 ammonium transporter; Provisional; Region: PRK10666 1286170008796 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1286170008797 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1286170008798 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1286170008799 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286170008800 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1286170008801 Walker A/P-loop; other site 1286170008802 ATP binding site [chemical binding]; other site 1286170008803 Q-loop/lid; other site 1286170008804 ABC transporter signature motif; other site 1286170008805 Walker B; other site 1286170008806 D-loop; other site 1286170008807 H-loop/switch region; other site 1286170008808 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1286170008809 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286170008810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170008811 Walker A/P-loop; other site 1286170008812 ATP binding site [chemical binding]; other site 1286170008813 Q-loop/lid; other site 1286170008814 ABC transporter signature motif; other site 1286170008815 Walker B; other site 1286170008816 D-loop; other site 1286170008817 H-loop/switch region; other site 1286170008818 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286170008819 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286170008820 putative DNA binding site [nucleotide binding]; other site 1286170008821 putative Zn2+ binding site [ion binding]; other site 1286170008822 AsnC family; Region: AsnC_trans_reg; pfam01037 1286170008823 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1286170008824 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1286170008825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286170008826 catalytic residue [active] 1286170008827 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1286170008828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170008829 active site 1286170008830 motif I; other site 1286170008831 motif II; other site 1286170008832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1286170008833 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1286170008834 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1286170008835 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1286170008836 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1286170008837 Ligand Binding Site [chemical binding]; other site 1286170008838 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1286170008839 active site 1286170008840 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1286170008841 periplasmic folding chaperone; Provisional; Region: PRK10788 1286170008842 SurA N-terminal domain; Region: SurA_N_3; cl07813 1286170008843 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1286170008844 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286170008845 IHF dimer interface [polypeptide binding]; other site 1286170008846 IHF - DNA interface [nucleotide binding]; other site 1286170008847 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1286170008848 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1286170008849 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1286170008850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170008851 Walker A motif; other site 1286170008852 ATP binding site [chemical binding]; other site 1286170008853 Walker B motif; other site 1286170008854 arginine finger; other site 1286170008855 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1286170008856 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1286170008857 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1286170008858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170008859 Walker A motif; other site 1286170008860 ATP binding site [chemical binding]; other site 1286170008861 Walker B motif; other site 1286170008862 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1286170008863 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1286170008864 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1286170008865 oligomer interface [polypeptide binding]; other site 1286170008866 active site residues [active] 1286170008867 trigger factor; Provisional; Region: tig; PRK01490 1286170008868 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1286170008869 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1286170008870 transcriptional regulator BolA; Provisional; Region: PRK11628 1286170008871 hypothetical protein; Provisional; Region: PRK11627 1286170008872 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1286170008873 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1286170008874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170008875 putative substrate translocation pore; other site 1286170008876 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1286170008877 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1286170008878 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1286170008879 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1286170008880 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1286170008881 D-pathway; other site 1286170008882 Putative ubiquinol binding site [chemical binding]; other site 1286170008883 Low-spin heme (heme b) binding site [chemical binding]; other site 1286170008884 Putative water exit pathway; other site 1286170008885 Binuclear center (heme o3/CuB) [ion binding]; other site 1286170008886 K-pathway; other site 1286170008887 Putative proton exit pathway; other site 1286170008888 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1286170008889 Subunit I/III interface [polypeptide binding]; other site 1286170008890 Subunit III/IV interface [polypeptide binding]; other site 1286170008891 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1286170008892 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1286170008893 UbiA prenyltransferase family; Region: UbiA; pfam01040 1286170008894 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1286170008895 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286170008896 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286170008897 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1286170008898 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1286170008899 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1286170008900 shikimate binding site; other site 1286170008901 NAD(P) binding site [chemical binding]; other site 1286170008902 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 1286170008903 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286170008904 NIPSNAP; Region: NIPSNAP; pfam07978 1286170008905 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 1286170008906 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1286170008907 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1286170008908 benzoate transport; Region: 2A0115; TIGR00895 1286170008909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170008910 putative substrate translocation pore; other site 1286170008911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170008912 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286170008913 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286170008914 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286170008915 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286170008916 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286170008917 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286170008918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170008919 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170008920 putative substrate translocation pore; other site 1286170008921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1286170008922 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1286170008923 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1286170008924 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1286170008925 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1286170008926 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1286170008927 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1286170008928 conserved cys residue [active] 1286170008929 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1286170008930 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1286170008931 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1286170008932 Ligand Binding Site [chemical binding]; other site 1286170008933 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1286170008934 active site residue [active] 1286170008935 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1286170008936 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1286170008937 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1286170008938 substrate binding pocket [chemical binding]; other site 1286170008939 chain length determination region; other site 1286170008940 substrate-Mg2+ binding site; other site 1286170008941 catalytic residues [active] 1286170008942 aspartate-rich region 1; other site 1286170008943 active site lid residues [active] 1286170008944 aspartate-rich region 2; other site 1286170008945 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1286170008946 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1286170008947 TPP-binding site; other site 1286170008948 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286170008949 PYR/PP interface [polypeptide binding]; other site 1286170008950 dimer interface [polypeptide binding]; other site 1286170008951 TPP binding site [chemical binding]; other site 1286170008952 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286170008953 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170008954 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170008955 active site 1286170008956 catalytic tetrad [active] 1286170008957 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1286170008958 tetramer interfaces [polypeptide binding]; other site 1286170008959 binuclear metal-binding site [ion binding]; other site 1286170008960 thiamine monophosphate kinase; Provisional; Region: PRK05731 1286170008961 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1286170008962 ATP binding site [chemical binding]; other site 1286170008963 dimerization interface [polypeptide binding]; other site 1286170008964 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1286170008965 putative RNA binding site [nucleotide binding]; other site 1286170008966 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1286170008967 homopentamer interface [polypeptide binding]; other site 1286170008968 active site 1286170008969 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1286170008970 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1286170008971 catalytic motif [active] 1286170008972 Zn binding site [ion binding]; other site 1286170008973 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1286170008974 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1286170008975 ATP cone domain; Region: ATP-cone; pfam03477 1286170008976 hypothetical protein; Provisional; Region: PRK11530 1286170008977 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1286170008978 Predicted transcriptional regulator [Transcription]; Region: COG2378 1286170008979 HTH domain; Region: HTH_11; pfam08279 1286170008980 WYL domain; Region: WYL; pfam13280 1286170008981 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1286170008982 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286170008983 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1286170008984 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1286170008985 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1286170008986 active site 1286170008987 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1286170008988 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1286170008989 Protein export membrane protein; Region: SecD_SecF; pfam02355 1286170008990 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1286170008991 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1286170008992 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1286170008993 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1286170008994 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1286170008995 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1286170008996 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1286170008997 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1286170008998 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1286170008999 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1286170009000 peroxidase; Provisional; Region: PRK15000 1286170009001 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1286170009002 dimer interface [polypeptide binding]; other site 1286170009003 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1286170009004 catalytic triad [active] 1286170009005 peroxidatic and resolving cysteines [active] 1286170009006 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286170009007 active site 1286170009008 phosphorylation site [posttranslational modification] 1286170009009 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1286170009010 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1286170009011 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1286170009012 substrate binding site [chemical binding]; other site 1286170009013 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170009014 ATP binding site [chemical binding]; other site 1286170009015 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1286170009016 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1286170009017 intersubunit interface [polypeptide binding]; other site 1286170009018 active site 1286170009019 zinc binding site [ion binding]; other site 1286170009020 Na+ binding site [ion binding]; other site 1286170009021 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1286170009022 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1286170009023 active site 1286170009024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1286170009025 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1286170009026 Isochorismatase family; Region: Isochorismatase; pfam00857 1286170009027 catalytic triad [active] 1286170009028 dimer interface [polypeptide binding]; other site 1286170009029 conserved cis-peptide bond; other site 1286170009030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170009031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170009032 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170009033 dimerization interface [polypeptide binding]; other site 1286170009034 maltodextrin glucosidase; Provisional; Region: PRK10785 1286170009035 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1286170009036 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1286170009037 active site 1286170009038 homodimer interface [polypeptide binding]; other site 1286170009039 catalytic site [active] 1286170009040 putative proline-specific permease; Provisional; Region: proY; PRK10580 1286170009041 Spore germination protein; Region: Spore_permease; cl17796 1286170009042 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1286170009043 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1286170009044 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1286170009045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286170009046 putative active site [active] 1286170009047 heme pocket [chemical binding]; other site 1286170009048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170009049 dimer interface [polypeptide binding]; other site 1286170009050 phosphorylation site [posttranslational modification] 1286170009051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170009052 ATP binding site [chemical binding]; other site 1286170009053 Mg2+ binding site [ion binding]; other site 1286170009054 G-X-G motif; other site 1286170009055 transcriptional regulator PhoB; Provisional; Region: PRK10161 1286170009056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170009057 active site 1286170009058 phosphorylation site [posttranslational modification] 1286170009059 intermolecular recognition site; other site 1286170009060 dimerization interface [polypeptide binding]; other site 1286170009061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170009062 DNA binding site [nucleotide binding] 1286170009063 exonuclease subunit SbcD; Provisional; Region: PRK10966 1286170009064 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1286170009065 active site 1286170009066 metal binding site [ion binding]; metal-binding site 1286170009067 DNA binding site [nucleotide binding] 1286170009068 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1286170009069 exonuclease subunit SbcC; Provisional; Region: PRK10246 1286170009070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170009071 Walker A/P-loop; other site 1286170009072 ATP binding site [chemical binding]; other site 1286170009073 Q-loop/lid; other site 1286170009074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170009075 ABC transporter signature motif; other site 1286170009076 Walker B; other site 1286170009077 D-loop; other site 1286170009078 H-loop/switch region; other site 1286170009079 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 1286170009080 fructokinase; Reviewed; Region: PRK09557 1286170009081 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286170009082 nucleotide binding site [chemical binding]; other site 1286170009083 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1286170009084 hypothetical protein; Provisional; Region: PRK10579 1286170009085 hypothetical protein; Provisional; Region: PRK10481 1286170009086 hypothetical protein; Provisional; Region: PRK10380 1286170009087 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1286170009088 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1286170009089 ADP binding site [chemical binding]; other site 1286170009090 magnesium binding site [ion binding]; other site 1286170009091 putative shikimate binding site; other site 1286170009092 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1286170009093 hypothetical protein; Validated; Region: PRK00124 1286170009094 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1286170009095 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1286170009096 hypothetical protein; Provisional; Region: PRK11505 1286170009097 psiF repeat; Region: PsiF_repeat; pfam07769 1286170009098 psiF repeat; Region: PsiF_repeat; pfam07769 1286170009099 alkaline phosphatase; Provisional; Region: PRK10518 1286170009100 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1286170009101 active site 1286170009102 dimer interface [polypeptide binding]; other site 1286170009103 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; cl11681 1286170009104 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1286170009105 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170009106 DNA binding site [nucleotide binding] 1286170009107 domain linker motif; other site 1286170009108 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1286170009109 putative dimerization interface [polypeptide binding]; other site 1286170009110 putative ligand binding site [chemical binding]; other site 1286170009111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170009112 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170009113 putative substrate translocation pore; other site 1286170009114 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1286170009115 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1286170009116 NADP binding site [chemical binding]; other site 1286170009117 homodimer interface [polypeptide binding]; other site 1286170009118 active site 1286170009119 drug efflux system protein MdtG; Provisional; Region: PRK09874 1286170009120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170009121 putative substrate translocation pore; other site 1286170009122 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1286170009123 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1286170009124 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1286170009125 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1286170009126 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1286170009127 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1286170009128 microcin B17 transporter; Reviewed; Region: PRK11098 1286170009129 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1286170009130 Isochorismatase family; Region: Isochorismatase; pfam00857 1286170009131 catalytic triad [active] 1286170009132 conserved cis-peptide bond; other site 1286170009133 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1286170009134 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286170009135 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1286170009136 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1286170009137 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1286170009138 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1286170009139 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1286170009140 dimer interface [polypeptide binding]; other site 1286170009141 active site 1286170009142 Schiff base residues; other site 1286170009143 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 1286170009144 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1286170009145 putative acyl-acceptor binding pocket; other site 1286170009146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1286170009147 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1286170009148 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1286170009149 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286170009150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170009151 dimer interface [polypeptide binding]; other site 1286170009152 conserved gate region; other site 1286170009153 putative PBP binding loops; other site 1286170009154 ABC-ATPase subunit interface; other site 1286170009155 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1286170009156 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286170009157 Walker A/P-loop; other site 1286170009158 ATP binding site [chemical binding]; other site 1286170009159 Q-loop/lid; other site 1286170009160 ABC transporter signature motif; other site 1286170009161 Walker B; other site 1286170009162 D-loop; other site 1286170009163 H-loop/switch region; other site 1286170009164 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1286170009165 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170009166 substrate binding pocket [chemical binding]; other site 1286170009167 membrane-bound complex binding site; other site 1286170009168 hinge residues; other site 1286170009169 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286170009170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170009171 active site 1286170009172 phosphorylation site [posttranslational modification] 1286170009173 intermolecular recognition site; other site 1286170009174 dimerization interface [polypeptide binding]; other site 1286170009175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170009176 DNA binding residues [nucleotide binding] 1286170009177 dimerization interface [polypeptide binding]; other site 1286170009178 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 1286170009179 MASE1; Region: MASE1; pfam05231 1286170009180 Histidine kinase; Region: HisKA_3; pfam07730 1286170009181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170009182 ATP binding site [chemical binding]; other site 1286170009183 Mg2+ binding site [ion binding]; other site 1286170009184 G-X-G motif; other site 1286170009185 regulatory protein UhpC; Provisional; Region: PRK11663 1286170009186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170009187 putative substrate translocation pore; other site 1286170009188 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286170009189 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286170009190 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286170009191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170009192 dimer interface [polypeptide binding]; other site 1286170009193 conserved gate region; other site 1286170009194 putative PBP binding loops; other site 1286170009195 ABC-ATPase subunit interface; other site 1286170009196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170009197 dimer interface [polypeptide binding]; other site 1286170009198 conserved gate region; other site 1286170009199 putative PBP binding loops; other site 1286170009200 ABC-ATPase subunit interface; other site 1286170009201 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 1286170009202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170009203 Walker A/P-loop; other site 1286170009204 ATP binding site [chemical binding]; other site 1286170009205 Q-loop/lid; other site 1286170009206 ABC transporter signature motif; other site 1286170009207 Walker B; other site 1286170009208 D-loop; other site 1286170009209 H-loop/switch region; other site 1286170009210 TOBE domain; Region: TOBE_2; pfam08402 1286170009211 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1286170009212 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1286170009213 S-methylmethionine transporter; Provisional; Region: PRK11387 1286170009214 ethanolamine permease; Region: 2A0305; TIGR00908 1286170009215 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1286170009216 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1286170009217 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1286170009218 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170009219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170009220 substrate binding pocket [chemical binding]; other site 1286170009221 membrane-bound complex binding site; other site 1286170009222 hinge residues; other site 1286170009223 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286170009224 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286170009225 Walker A/P-loop; other site 1286170009226 ATP binding site [chemical binding]; other site 1286170009227 Q-loop/lid; other site 1286170009228 ABC transporter signature motif; other site 1286170009229 Walker B; other site 1286170009230 D-loop; other site 1286170009231 H-loop/switch region; other site 1286170009232 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170009233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170009234 dimer interface [polypeptide binding]; other site 1286170009235 conserved gate region; other site 1286170009236 putative PBP binding loops; other site 1286170009237 ABC-ATPase subunit interface; other site 1286170009238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170009239 dimer interface [polypeptide binding]; other site 1286170009240 conserved gate region; other site 1286170009241 putative PBP binding loops; other site 1286170009242 ABC-ATPase subunit interface; other site 1286170009243 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1286170009244 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1286170009245 Walker A/P-loop; other site 1286170009246 ATP binding site [chemical binding]; other site 1286170009247 Q-loop/lid; other site 1286170009248 ABC transporter signature motif; other site 1286170009249 Walker B; other site 1286170009250 D-loop; other site 1286170009251 H-loop/switch region; other site 1286170009252 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1286170009253 Transferrin; Region: Transferrin; cl02460 1286170009254 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1286170009255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170009256 dimer interface [polypeptide binding]; other site 1286170009257 conserved gate region; other site 1286170009258 putative PBP binding loops; other site 1286170009259 ABC-ATPase subunit interface; other site 1286170009260 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1286170009261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170009262 dimer interface [polypeptide binding]; other site 1286170009263 conserved gate region; other site 1286170009264 putative PBP binding loops; other site 1286170009265 ABC-ATPase subunit interface; other site 1286170009266 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1286170009267 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1286170009268 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286170009269 Cupin domain; Region: Cupin_2; cl17218 1286170009270 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170009271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170009272 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1286170009273 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286170009274 catalytic residues [active] 1286170009275 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286170009276 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286170009277 Walker A/P-loop; other site 1286170009278 ATP binding site [chemical binding]; other site 1286170009279 Q-loop/lid; other site 1286170009280 ABC transporter signature motif; other site 1286170009281 Walker B; other site 1286170009282 D-loop; other site 1286170009283 H-loop/switch region; other site 1286170009284 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286170009285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170009286 dimer interface [polypeptide binding]; other site 1286170009287 conserved gate region; other site 1286170009288 putative PBP binding loops; other site 1286170009289 ABC-ATPase subunit interface; other site 1286170009290 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286170009291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170009292 dimer interface [polypeptide binding]; other site 1286170009293 conserved gate region; other site 1286170009294 putative PBP binding loops; other site 1286170009295 ABC-ATPase subunit interface; other site 1286170009296 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1286170009297 membrane-bound complex binding site; other site 1286170009298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170009299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170009300 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286170009301 dimerization interface [polypeptide binding]; other site 1286170009302 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1286170009303 NlpC/P60 family; Region: NLPC_P60; pfam00877 1286170009304 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1286170009305 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1286170009306 trimer interface [polypeptide binding]; other site 1286170009307 eyelet of channel; other site 1286170009308 gamma-glutamyl kinase; Provisional; Region: PRK05429 1286170009309 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1286170009310 nucleotide binding site [chemical binding]; other site 1286170009311 homotetrameric interface [polypeptide binding]; other site 1286170009312 putative phosphate binding site [ion binding]; other site 1286170009313 putative allosteric binding site; other site 1286170009314 PUA domain; Region: PUA; pfam01472 1286170009315 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1286170009316 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1286170009317 putative catalytic cysteine [active] 1286170009318 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1286170009319 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1286170009320 Ligand binding site; other site 1286170009321 Putative Catalytic site; other site 1286170009322 DXD motif; other site 1286170009323 Predicted membrane protein [Function unknown]; Region: COG2246 1286170009324 GtrA-like protein; Region: GtrA; pfam04138 1286170009325 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1286170009326 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1286170009327 substrate binding pocket [chemical binding]; other site 1286170009328 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286170009329 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1286170009330 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286170009331 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1286170009332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286170009333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170009334 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170009335 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170009336 DNA binding site [nucleotide binding] 1286170009337 domain linker motif; other site 1286170009338 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1286170009339 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 1286170009340 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286170009341 classical (c) SDRs; Region: SDR_c; cd05233 1286170009342 NAD(P) binding site [chemical binding]; other site 1286170009343 active site 1286170009344 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1286170009345 DctM-like transporters; Region: DctM; pfam06808 1286170009346 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1286170009347 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286170009348 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1286170009349 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1286170009350 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1286170009351 tetramerization interface [polypeptide binding]; other site 1286170009352 NAD(P) binding site [chemical binding]; other site 1286170009353 catalytic residues [active] 1286170009354 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1286170009355 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1286170009356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286170009357 active site 1286170009358 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1286170009359 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1286170009360 metal binding site [ion binding]; metal-binding site 1286170009361 dimer interface [polypeptide binding]; other site 1286170009362 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286170009363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170009364 Coenzyme A binding pocket [chemical binding]; other site 1286170009365 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1286170009366 active site 1286170009367 DNA polymerase IV; Validated; Region: PRK02406 1286170009368 DNA binding site [nucleotide binding] 1286170009369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 1286170009370 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1286170009371 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286170009372 catalytic loop [active] 1286170009373 iron binding site [ion binding]; other site 1286170009374 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1286170009375 FAD binding pocket [chemical binding]; other site 1286170009376 FAD binding motif [chemical binding]; other site 1286170009377 phosphate binding motif [ion binding]; other site 1286170009378 beta-alpha-beta structure motif; other site 1286170009379 NAD binding pocket [chemical binding]; other site 1286170009380 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1286170009381 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1286170009382 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1286170009383 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1286170009384 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1286170009385 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1286170009386 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286170009387 E3 interaction surface; other site 1286170009388 lipoyl attachment site [posttranslational modification]; other site 1286170009389 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1286170009390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1286170009391 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286170009392 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1286170009393 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1286170009394 putative active site [active] 1286170009395 putative dimer interface [polypeptide binding]; other site 1286170009396 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1286170009397 dimer interface [polypeptide binding]; other site 1286170009398 active site 1286170009399 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1286170009400 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286170009401 active site 1286170009402 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1286170009403 C-N hydrolase family amidase; Provisional; Region: PRK10438 1286170009404 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1286170009405 putative active site [active] 1286170009406 catalytic triad [active] 1286170009407 dimer interface [polypeptide binding]; other site 1286170009408 multimer interface [polypeptide binding]; other site 1286170009409 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286170009410 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1286170009411 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1286170009412 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1286170009413 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170009414 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170009415 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1286170009416 Ion channel; Region: Ion_trans_2; pfam07885 1286170009417 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1286170009418 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1286170009419 active site 1286170009420 catalytic site [active] 1286170009421 substrate binding site [chemical binding]; other site 1286170009422 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1286170009423 RNA/DNA hybrid binding site [nucleotide binding]; other site 1286170009424 active site 1286170009425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170009426 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1286170009427 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1286170009428 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286170009429 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286170009430 catalytic residue [active] 1286170009431 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286170009432 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286170009433 hypothetical protein; Provisional; Region: PRK08317 1286170009434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170009435 S-adenosylmethionine binding site [chemical binding]; other site 1286170009436 hypothetical protein; Provisional; Region: PRK05421 1286170009437 putative catalytic site [active] 1286170009438 putative metal binding site [ion binding]; other site 1286170009439 putative phosphate binding site [ion binding]; other site 1286170009440 putative catalytic site [active] 1286170009441 putative phosphate binding site [ion binding]; other site 1286170009442 putative metal binding site [ion binding]; other site 1286170009443 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286170009444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170009445 putative substrate translocation pore; other site 1286170009446 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170009447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170009448 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1286170009449 putative effector binding pocket; other site 1286170009450 dimerization interface [polypeptide binding]; other site 1286170009451 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170009452 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170009453 active site 1286170009454 catalytic tetrad [active] 1286170009455 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1286170009456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170009457 active site 1286170009458 motif I; other site 1286170009459 motif II; other site 1286170009460 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1286170009461 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1286170009462 Walker A/P-loop; other site 1286170009463 ATP binding site [chemical binding]; other site 1286170009464 Q-loop/lid; other site 1286170009465 ABC transporter signature motif; other site 1286170009466 Walker B; other site 1286170009467 D-loop; other site 1286170009468 H-loop/switch region; other site 1286170009469 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1286170009470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170009471 dimer interface [polypeptide binding]; other site 1286170009472 conserved gate region; other site 1286170009473 ABC-ATPase subunit interface; other site 1286170009474 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1286170009475 lipoprotein, YaeC family; Region: TIGR00363 1286170009476 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1286170009477 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1286170009478 homodimer interaction site [polypeptide binding]; other site 1286170009479 cofactor binding site; other site 1286170009480 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1286170009481 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1286170009482 dimer interface [polypeptide binding]; other site 1286170009483 motif 1; other site 1286170009484 active site 1286170009485 motif 2; other site 1286170009486 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1286170009487 putative deacylase active site [active] 1286170009488 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1286170009489 active site 1286170009490 motif 3; other site 1286170009491 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1286170009492 anticodon binding site; other site 1286170009493 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1286170009494 NlpE N-terminal domain; Region: NlpE; pfam04170 1286170009495 hypothetical protein; Provisional; Region: PRK09256 1286170009496 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1286170009497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1286170009498 hypothetical protein; Provisional; Region: PRK04964 1286170009499 Rho-binding antiterminator; Provisional; Region: PRK11625 1286170009500 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1286170009501 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1286170009502 Ligand Binding Site [chemical binding]; other site 1286170009503 TilS substrate binding domain; Region: TilS; pfam09179 1286170009504 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1286170009505 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1286170009506 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286170009507 putative metal binding site [ion binding]; other site 1286170009508 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1286170009509 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1286170009510 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1286170009511 homodimer interface [polypeptide binding]; other site 1286170009512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170009513 catalytic residue [active] 1286170009514 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1286170009515 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1286170009516 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1286170009517 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1286170009518 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1286170009519 putative active site [active] 1286170009520 putative PHP Thumb interface [polypeptide binding]; other site 1286170009521 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1286170009522 generic binding surface II; other site 1286170009523 generic binding surface I; other site 1286170009524 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1286170009525 RNA/DNA hybrid binding site [nucleotide binding]; other site 1286170009526 active site 1286170009527 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1286170009528 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1286170009529 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1286170009530 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1286170009531 active site 1286170009532 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1286170009533 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1286170009534 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1286170009535 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1286170009536 trimer interface [polypeptide binding]; other site 1286170009537 active site 1286170009538 UDP-GlcNAc binding site [chemical binding]; other site 1286170009539 lipid binding site [chemical binding]; lipid-binding site 1286170009540 periplasmic chaperone; Provisional; Region: PRK10780 1286170009541 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1286170009542 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1286170009543 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286170009544 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286170009545 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286170009546 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286170009547 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286170009548 Surface antigen; Region: Bac_surface_Ag; pfam01103 1286170009549 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1286170009550 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1286170009551 active site 1286170009552 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1286170009553 protein binding site [polypeptide binding]; other site 1286170009554 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1286170009555 protein binding site [polypeptide binding]; other site 1286170009556 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1286170009557 putative substrate binding region [chemical binding]; other site 1286170009558 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1286170009559 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1286170009560 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1286170009561 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1286170009562 catalytic residue [active] 1286170009563 putative FPP diphosphate binding site; other site 1286170009564 putative FPP binding hydrophobic cleft; other site 1286170009565 dimer interface [polypeptide binding]; other site 1286170009566 putative IPP diphosphate binding site; other site 1286170009567 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1286170009568 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1286170009569 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1286170009570 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1286170009571 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1286170009572 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1286170009573 hinge region; other site 1286170009574 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1286170009575 putative nucleotide binding site [chemical binding]; other site 1286170009576 uridine monophosphate binding site [chemical binding]; other site 1286170009577 homohexameric interface [polypeptide binding]; other site 1286170009578 elongation factor Ts; Provisional; Region: tsf; PRK09377 1286170009579 UBA/TS-N domain; Region: UBA; pfam00627 1286170009580 Elongation factor TS; Region: EF_TS; pfam00889 1286170009581 Elongation factor TS; Region: EF_TS; pfam00889 1286170009582 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1286170009583 rRNA interaction site [nucleotide binding]; other site 1286170009584 S8 interaction site; other site 1286170009585 putative laminin-1 binding site; other site 1286170009586 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1286170009587 active site 1286170009588 PII uridylyl-transferase; Provisional; Region: PRK05007 1286170009589 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1286170009590 metal binding triad; other site 1286170009591 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1286170009592 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286170009593 Zn2+ binding site [ion binding]; other site 1286170009594 Mg2+ binding site [ion binding]; other site 1286170009595 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1286170009596 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1286170009597 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1286170009598 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1286170009599 trimer interface [polypeptide binding]; other site 1286170009600 active site 1286170009601 substrate binding site [chemical binding]; other site 1286170009602 CoA binding site [chemical binding]; other site 1286170009603 hypothetical protein; Provisional; Region: PRK13677 1286170009604 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1286170009605 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1286170009606 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1286170009607 serine endoprotease; Provisional; Region: PRK10942 1286170009608 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1286170009609 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286170009610 protein binding site [polypeptide binding]; other site 1286170009611 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286170009612 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1286170009613 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286170009614 Zn2+ binding site [ion binding]; other site 1286170009615 Mg2+ binding site [ion binding]; other site 1286170009616 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1286170009617 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1286170009618 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1286170009619 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1286170009620 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1286170009621 cobalamin binding residues [chemical binding]; other site 1286170009622 putative BtuC binding residues; other site 1286170009623 dimer interface [polypeptide binding]; other site 1286170009624 hypothetical protein; Provisional; Region: PRK10578 1286170009625 UPF0126 domain; Region: UPF0126; pfam03458 1286170009626 UPF0126 domain; Region: UPF0126; pfam03458 1286170009627 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1286170009628 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1286170009629 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1286170009630 Cl- selectivity filter; other site 1286170009631 Cl- binding residues [ion binding]; other site 1286170009632 pore gating glutamate residue; other site 1286170009633 dimer interface [polypeptide binding]; other site 1286170009634 H+/Cl- coupling transport residue; other site 1286170009635 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1286170009636 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286170009637 inhibitor-cofactor binding pocket; inhibition site 1286170009638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170009639 catalytic residue [active] 1286170009640 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286170009641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170009642 ABC-ATPase subunit interface; other site 1286170009643 dimer interface [polypeptide binding]; other site 1286170009644 putative PBP binding regions; other site 1286170009645 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170009646 ABC-ATPase subunit interface; other site 1286170009647 dimer interface [polypeptide binding]; other site 1286170009648 putative PBP binding regions; other site 1286170009649 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1286170009650 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1286170009651 siderophore binding site; other site 1286170009652 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1286170009653 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286170009654 Walker A/P-loop; other site 1286170009655 ATP binding site [chemical binding]; other site 1286170009656 Q-loop/lid; other site 1286170009657 ABC transporter signature motif; other site 1286170009658 Walker B; other site 1286170009659 D-loop; other site 1286170009660 H-loop/switch region; other site 1286170009661 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1286170009662 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170009663 N-terminal plug; other site 1286170009664 ligand-binding site [chemical binding]; other site 1286170009665 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1286170009666 Transglycosylase; Region: Transgly; pfam00912 1286170009667 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1286170009668 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1286170009669 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1286170009670 carbohydrate binding site [chemical binding]; other site 1286170009671 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 1286170009672 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1286170009673 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1286170009674 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1286170009675 active site 1286170009676 catalytic site [active] 1286170009677 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 1286170009678 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 1286170009679 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1286170009680 PDZ domain (Also known as DHR or GLGF); Region: PDZ; pfam00595 1286170009681 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1286170009682 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1286170009683 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1286170009684 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1286170009685 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1286170009686 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1286170009687 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1286170009688 Walker A motif; other site 1286170009689 ATP binding site [chemical binding]; other site 1286170009690 Walker B motif; other site 1286170009691 type II secretion system protein F; Region: GspF; TIGR02120 1286170009692 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1286170009693 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1286170009694 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1286170009695 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1286170009696 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1286170009697 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1286170009698 type II secretion system protein I; Region: gspI; TIGR01707 1286170009699 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1286170009700 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1286170009701 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1286170009702 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1286170009703 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1286170009704 GspL periplasmic domain; Region: GspL_C; pfam12693 1286170009705 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1286170009706 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 1286170009707 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1286170009708 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1286170009709 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1286170009710 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1286170009711 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286170009712 ATP binding site [chemical binding]; other site 1286170009713 putative Mg++ binding site [ion binding]; other site 1286170009714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170009715 nucleotide binding region [chemical binding]; other site 1286170009716 ATP-binding site [chemical binding]; other site 1286170009717 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1286170009718 2'-5' RNA ligase; Provisional; Region: PRK15124 1286170009719 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1286170009720 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1286170009721 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1286170009722 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1286170009723 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1286170009724 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1286170009725 active site 1286170009726 HIGH motif; other site 1286170009727 nucleotide binding site [chemical binding]; other site 1286170009728 KMSKS motif; other site 1286170009729 poly(A) polymerase; Region: pcnB; TIGR01942 1286170009730 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1286170009731 active site 1286170009732 NTP binding site [chemical binding]; other site 1286170009733 metal binding triad [ion binding]; metal-binding site 1286170009734 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1286170009735 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1286170009736 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1286170009737 catalytic center binding site [active] 1286170009738 ATP binding site [chemical binding]; other site 1286170009739 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1286170009740 oligomerization interface [polypeptide binding]; other site 1286170009741 active site 1286170009742 metal binding site [ion binding]; metal-binding site 1286170009743 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1286170009744 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1286170009745 active site 1286170009746 ATP-binding site [chemical binding]; other site 1286170009747 pantoate-binding site; other site 1286170009748 HXXH motif; other site 1286170009749 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1286170009750 tetramerization interface [polypeptide binding]; other site 1286170009751 active site 1286170009752 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 1286170009753 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1286170009754 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286170009755 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1286170009756 putative active site [active] 1286170009757 putative metal binding site [ion binding]; other site 1286170009758 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1286170009759 active pocket/dimerization site; other site 1286170009760 active site 1286170009761 phosphorylation site [posttranslational modification] 1286170009762 inner membrane transport permease; Provisional; Region: PRK15066 1286170009763 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1286170009764 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286170009765 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286170009766 Walker A/P-loop; other site 1286170009767 ATP binding site [chemical binding]; other site 1286170009768 Q-loop/lid; other site 1286170009769 ABC transporter signature motif; other site 1286170009770 Walker B; other site 1286170009771 D-loop; other site 1286170009772 H-loop/switch region; other site 1286170009773 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1286170009774 active site clefts [active] 1286170009775 zinc binding site [ion binding]; other site 1286170009776 dimer interface [polypeptide binding]; other site 1286170009777 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286170009778 active site 1286170009779 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1286170009780 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1286170009781 Trp docking motif [polypeptide binding]; other site 1286170009782 putative active site [active] 1286170009783 multicopper oxidase; Provisional; Region: PRK10965 1286170009784 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1286170009785 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1286170009786 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1286170009787 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1286170009788 spermidine synthase; Provisional; Region: PRK00811 1286170009789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170009790 S-adenosylmethionine binding site [chemical binding]; other site 1286170009791 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1286170009792 hypothetical protein; Provisional; Region: PRK05248 1286170009793 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1286170009794 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1286170009795 substrate binding site [chemical binding]; other site 1286170009796 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1286170009797 substrate binding site [chemical binding]; other site 1286170009798 ligand binding site [chemical binding]; other site 1286170009799 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1286170009800 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1286170009801 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1286170009802 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170009803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170009804 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286170009805 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1286170009806 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286170009807 E3 interaction surface; other site 1286170009808 lipoyl attachment site [posttranslational modification]; other site 1286170009809 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286170009810 E3 interaction surface; other site 1286170009811 lipoyl attachment site [posttranslational modification]; other site 1286170009812 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286170009813 E3 interaction surface; other site 1286170009814 lipoyl attachment site [posttranslational modification]; other site 1286170009815 e3 binding domain; Region: E3_binding; pfam02817 1286170009816 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1286170009817 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1286170009818 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1286170009819 dimer interface [polypeptide binding]; other site 1286170009820 TPP-binding site [chemical binding]; other site 1286170009821 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1286170009822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170009823 DNA-binding site [nucleotide binding]; DNA binding site 1286170009824 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286170009825 aromatic amino acid transporter; Provisional; Region: PRK10238 1286170009826 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1286170009827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170009828 putative substrate translocation pore; other site 1286170009829 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1286170009830 active site 1286170009831 regulatory protein AmpE; Provisional; Region: PRK10987 1286170009832 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1286170009833 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286170009834 amidase catalytic site [active] 1286170009835 substrate binding site [chemical binding]; other site 1286170009836 Zn binding residues [ion binding]; other site 1286170009837 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1286170009838 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1286170009839 dimerization interface [polypeptide binding]; other site 1286170009840 active site 1286170009841 putative major pilin subunit; Provisional; Region: PRK10574 1286170009842 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1286170009843 Protein of unknown function DUF262; Region: DUF262; pfam03235 1286170009844 Protein of unknown function DUF262; Region: DUF262; pfam03235 1286170009845 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1286170009846 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286170009847 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1286170009848 catalytic residues [active] 1286170009849 catalytic nucleophile [active] 1286170009850 Presynaptic Site I dimer interface [polypeptide binding]; other site 1286170009851 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1286170009852 Synaptic Flat tetramer interface [polypeptide binding]; other site 1286170009853 Synaptic Site I dimer interface [polypeptide binding]; other site 1286170009854 DNA binding site [nucleotide binding] 1286170009855 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1286170009856 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286170009857 putative active site [active] 1286170009858 putative NTP binding site [chemical binding]; other site 1286170009859 putative nucleic acid binding site [nucleotide binding]; other site 1286170009860 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 1286170009861 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170009862 sequence-specific DNA binding site [nucleotide binding]; other site 1286170009863 salt bridge; other site 1286170009864 Predicted transcriptional regulator [Transcription]; Region: COG2932 1286170009865 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1286170009866 Catalytic site [active] 1286170009867 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1286170009868 catalytic residues [active] 1286170009869 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1286170009870 putative major pilin subunit; Provisional; Region: PRK10574 1286170009871 Pilin (bacterial filament); Region: Pilin; pfam00114 1286170009872 hypothetical protein; Provisional; Region: PRK10436 1286170009873 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1286170009874 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1286170009875 Walker A motif; other site 1286170009876 ATP binding site [chemical binding]; other site 1286170009877 Walker B motif; other site 1286170009878 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1286170009879 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1286170009880 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1286170009881 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1286170009882 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1286170009883 active site 1286170009884 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1286170009885 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1286170009886 CoA-binding site [chemical binding]; other site 1286170009887 ATP-binding [chemical binding]; other site 1286170009888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1286170009889 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1286170009890 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1286170009891 active site 1286170009892 8-oxo-dGMP binding site [chemical binding]; other site 1286170009893 nudix motif; other site 1286170009894 metal binding site [ion binding]; metal-binding site 1286170009895 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1286170009896 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1286170009897 SEC-C motif; Region: SEC-C; pfam02810 1286170009898 SecA regulator SecM; Provisional; Region: PRK02943 1286170009899 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1286170009900 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1286170009901 cell division protein FtsZ; Validated; Region: PRK09330 1286170009902 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1286170009903 nucleotide binding site [chemical binding]; other site 1286170009904 SulA interaction site; other site 1286170009905 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1286170009906 Cell division protein FtsA; Region: FtsA; pfam14450 1286170009907 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286170009908 Cell division protein FtsA; Region: FtsA; pfam14450 1286170009909 cell division protein FtsQ; Provisional; Region: PRK10775 1286170009910 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1286170009911 Cell division protein FtsQ; Region: FtsQ; pfam03799 1286170009912 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1286170009913 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1286170009914 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1286170009915 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1286170009916 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1286170009917 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286170009918 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286170009919 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1286170009920 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1286170009921 active site 1286170009922 homodimer interface [polypeptide binding]; other site 1286170009923 cell division protein FtsW; Provisional; Region: PRK10774 1286170009924 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1286170009925 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286170009926 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286170009927 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1286170009928 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1286170009929 Mg++ binding site [ion binding]; other site 1286170009930 putative catalytic motif [active] 1286170009931 putative substrate binding site [chemical binding]; other site 1286170009932 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1286170009933 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1286170009934 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286170009935 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286170009936 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1286170009937 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1286170009938 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286170009939 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286170009940 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1286170009941 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286170009942 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286170009943 cell division protein FtsL; Provisional; Region: PRK10772 1286170009944 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1286170009945 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1286170009946 mraZ protein; Region: TIGR00242 1286170009947 MraZ protein; Region: MraZ; pfam02381 1286170009948 MraZ protein; Region: MraZ; pfam02381 1286170009949 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1286170009950 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170009951 DNA binding site [nucleotide binding] 1286170009952 domain linker motif; other site 1286170009953 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1286170009954 dimerization interface [polypeptide binding]; other site 1286170009955 ligand binding site [chemical binding]; other site 1286170009956 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1286170009957 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1286170009958 putative valine binding site [chemical binding]; other site 1286170009959 dimer interface [polypeptide binding]; other site 1286170009960 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1286170009961 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1286170009962 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286170009963 PYR/PP interface [polypeptide binding]; other site 1286170009964 dimer interface [polypeptide binding]; other site 1286170009965 TPP binding site [chemical binding]; other site 1286170009966 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286170009967 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1286170009968 TPP-binding site [chemical binding]; other site 1286170009969 dimer interface [polypeptide binding]; other site 1286170009970 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1286170009971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170009972 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1286170009973 putative substrate binding pocket [chemical binding]; other site 1286170009974 putative dimerization interface [polypeptide binding]; other site 1286170009975 2-isopropylmalate synthase; Validated; Region: PRK00915 1286170009976 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1286170009977 active site 1286170009978 catalytic residues [active] 1286170009979 metal binding site [ion binding]; metal-binding site 1286170009980 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1286170009981 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1286170009982 tartrate dehydrogenase; Region: TTC; TIGR02089 1286170009983 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1286170009984 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1286170009985 substrate binding site [chemical binding]; other site 1286170009986 ligand binding site [chemical binding]; other site 1286170009987 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1286170009988 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1286170009989 substrate binding site [chemical binding]; other site 1286170009990 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1286170009991 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1286170009992 active site 1286170009993 catalytic residue [active] 1286170009994 dimer interface [polypeptide binding]; other site 1286170009995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170009996 sugar efflux transporter; Region: 2A0120; TIGR00899 1286170009997 putative substrate translocation pore; other site 1286170009998 transcriptional regulator SgrR; Provisional; Region: PRK13626 1286170009999 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1286170010000 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1286170010001 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1286170010002 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1286170010003 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1286170010004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170010005 dimer interface [polypeptide binding]; other site 1286170010006 conserved gate region; other site 1286170010007 putative PBP binding loops; other site 1286170010008 ABC-ATPase subunit interface; other site 1286170010009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170010010 dimer interface [polypeptide binding]; other site 1286170010011 conserved gate region; other site 1286170010012 putative PBP binding loops; other site 1286170010013 ABC-ATPase subunit interface; other site 1286170010014 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1286170010015 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1286170010016 Walker A/P-loop; other site 1286170010017 ATP binding site [chemical binding]; other site 1286170010018 Q-loop/lid; other site 1286170010019 ABC transporter signature motif; other site 1286170010020 Walker B; other site 1286170010021 D-loop; other site 1286170010022 H-loop/switch region; other site 1286170010023 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286170010024 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286170010025 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1286170010026 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286170010027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170010028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170010029 ribulokinase; Provisional; Region: PRK04123 1286170010030 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1286170010031 N- and C-terminal domain interface [polypeptide binding]; other site 1286170010032 active site 1286170010033 MgATP binding site [chemical binding]; other site 1286170010034 catalytic site [active] 1286170010035 metal binding site [ion binding]; metal-binding site 1286170010036 carbohydrate binding site [chemical binding]; other site 1286170010037 homodimer interface [polypeptide binding]; other site 1286170010038 L-arabinose isomerase; Provisional; Region: PRK02929 1286170010039 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1286170010040 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1286170010041 trimer interface [polypeptide binding]; other site 1286170010042 putative substrate binding site [chemical binding]; other site 1286170010043 putative metal binding site [ion binding]; other site 1286170010044 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1286170010045 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1286170010046 intersubunit interface [polypeptide binding]; other site 1286170010047 active site 1286170010048 Zn2+ binding site [ion binding]; other site 1286170010049 DNA polymerase II; Reviewed; Region: PRK05762 1286170010050 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1286170010051 active site 1286170010052 catalytic site [active] 1286170010053 substrate binding site [chemical binding]; other site 1286170010054 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1286170010055 active site 1286170010056 metal-binding site 1286170010057 ATP-dependent helicase HepA; Validated; Region: PRK04914 1286170010058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286170010059 ATP binding site [chemical binding]; other site 1286170010060 putative Mg++ binding site [ion binding]; other site 1286170010061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170010062 nucleotide binding region [chemical binding]; other site 1286170010063 ATP-binding site [chemical binding]; other site 1286170010064 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1286170010065 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1286170010066 active site 1286170010067 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 1286170010068 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1286170010069 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1286170010070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286170010071 putative active site [active] 1286170010072 heme pocket [chemical binding]; other site 1286170010073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170010074 ATP binding site [chemical binding]; other site 1286170010075 Mg2+ binding site [ion binding]; other site 1286170010076 G-X-G motif; other site 1286170010077 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1286170010078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170010079 active site 1286170010080 phosphorylation site [posttranslational modification] 1286170010081 intermolecular recognition site; other site 1286170010082 dimerization interface [polypeptide binding]; other site 1286170010083 Transcriptional regulator; Region: CitT; pfam12431 1286170010084 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1286170010085 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1286170010086 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1286170010087 putative metal binding site [ion binding]; other site 1286170010088 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1286170010089 HSP70 interaction site [polypeptide binding]; other site 1286170010090 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1286170010091 OstA-like protein; Region: OstA; pfam03968 1286170010092 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1286170010093 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1286170010094 SurA N-terminal domain; Region: SurA_N; pfam09312 1286170010095 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1286170010096 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1286170010097 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1286170010098 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1286170010099 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1286170010100 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1286170010101 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1286170010102 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1286170010103 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1286170010104 active site 1286170010105 metal binding site [ion binding]; metal-binding site 1286170010106 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1286170010107 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1286170010108 folate binding site [chemical binding]; other site 1286170010109 NADP+ binding site [chemical binding]; other site 1286170010110 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1286170010111 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1286170010112 TrkA-N domain; Region: TrkA_N; pfam02254 1286170010113 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1286170010114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170010115 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170010116 putative substrate translocation pore; other site 1286170010117 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1286170010118 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1286170010119 putative ligand binding site [chemical binding]; other site 1286170010120 NAD binding site [chemical binding]; other site 1286170010121 catalytic site [active] 1286170010122 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1286170010123 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170010124 DNA binding site [nucleotide binding] 1286170010125 domain linker motif; other site 1286170010126 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1286170010127 putative ligand binding site [chemical binding]; other site 1286170010128 putative dimerization interface [polypeptide binding]; other site 1286170010129 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1286170010130 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1286170010131 NADP binding site [chemical binding]; other site 1286170010132 homodimer interface [polypeptide binding]; other site 1286170010133 active site 1286170010134 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1286170010135 ATP-binding site [chemical binding]; other site 1286170010136 Gluconate-6-phosphate binding site [chemical binding]; other site 1286170010137 Shikimate kinase; Region: SKI; pfam01202 1286170010138 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1286170010139 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1286170010140 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1286170010141 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286170010142 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1286170010143 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1286170010144 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286170010145 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1286170010146 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1286170010147 IMP binding site; other site 1286170010148 dimer interface [polypeptide binding]; other site 1286170010149 interdomain contacts; other site 1286170010150 partial ornithine binding site; other site 1286170010151 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1286170010152 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1286170010153 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1286170010154 catalytic site [active] 1286170010155 subunit interface [polypeptide binding]; other site 1286170010156 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1286170010157 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1286170010158 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1286170010159 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170010160 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170010161 DNA binding site [nucleotide binding] 1286170010162 domain linker motif; other site 1286170010163 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1286170010164 putative ligand binding site [chemical binding]; other site 1286170010165 putative dimerization interface [polypeptide binding]; other site 1286170010166 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1286170010167 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1286170010168 active site 1286170010169 active pocket/dimerization site; other site 1286170010170 phosphorylation site [posttranslational modification] 1286170010171 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1286170010172 active site 1286170010173 phosphorylation site [posttranslational modification] 1286170010174 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1286170010175 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1286170010176 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 1286170010177 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 1286170010178 alanine-tRNA ligase; Region: PLN02961 1286170010179 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1286170010180 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170010181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170010182 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170010183 putative effector binding pocket; other site 1286170010184 dimerization interface [polypeptide binding]; other site 1286170010185 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1286170010186 active site 1286170010187 tetramer interface [polypeptide binding]; other site 1286170010188 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1286170010189 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1286170010190 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1286170010191 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1286170010192 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1286170010193 lipoprotein signal peptidase; Provisional; Region: PRK14787 1286170010194 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1286170010195 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1286170010196 active site 1286170010197 HIGH motif; other site 1286170010198 nucleotide binding site [chemical binding]; other site 1286170010199 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1286170010200 active site 1286170010201 KMSKS motif; other site 1286170010202 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1286170010203 tRNA binding surface [nucleotide binding]; other site 1286170010204 anticodon binding site; other site 1286170010205 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1286170010206 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1286170010207 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1286170010208 active site 1286170010209 Riboflavin kinase; Region: Flavokinase; smart00904 1286170010210 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1286170010211 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1286170010212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170010213 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1286170010214 putative dimerization interface [polypeptide binding]; other site 1286170010215 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1286170010216 chaperone protein DnaJ; Provisional; Region: PRK10767 1286170010217 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1286170010218 HSP70 interaction site [polypeptide binding]; other site 1286170010219 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1286170010220 substrate binding site [polypeptide binding]; other site 1286170010221 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1286170010222 Zn binding sites [ion binding]; other site 1286170010223 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1286170010224 dimer interface [polypeptide binding]; other site 1286170010225 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1286170010226 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286170010227 nucleotide binding site [chemical binding]; other site 1286170010228 hypothetical protein; Provisional; Region: PRK10659 1286170010229 metabolite-proton symporter; Region: 2A0106; TIGR00883 1286170010230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170010231 putative substrate translocation pore; other site 1286170010232 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1286170010233 MPT binding site; other site 1286170010234 trimer interface [polypeptide binding]; other site 1286170010235 transaldolase-like protein; Provisional; Region: PTZ00411 1286170010236 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1286170010237 active site 1286170010238 dimer interface [polypeptide binding]; other site 1286170010239 catalytic residue [active] 1286170010240 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1286170010241 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1286170010242 hypothetical protein; Validated; Region: PRK02101 1286170010243 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1286170010244 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1286170010245 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1286170010246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170010247 catalytic residue [active] 1286170010248 homoserine kinase; Provisional; Region: PRK01212 1286170010249 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1286170010250 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1286170010251 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1286170010252 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1286170010253 putative catalytic residues [active] 1286170010254 putative nucleotide binding site [chemical binding]; other site 1286170010255 putative aspartate binding site [chemical binding]; other site 1286170010256 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1286170010257 dimer interface [polypeptide binding]; other site 1286170010258 putative threonine allosteric regulatory site; other site 1286170010259 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1286170010260 putative threonine allosteric regulatory site; other site 1286170010261 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1286170010262 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1286170010263 putative RNA methyltransferase; Provisional; Region: PRK10433 1286170010264 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 1286170010265 two-component response regulator; Provisional; Region: PRK11173 1286170010266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170010267 active site 1286170010268 phosphorylation site [posttranslational modification] 1286170010269 intermolecular recognition site; other site 1286170010270 dimerization interface [polypeptide binding]; other site 1286170010271 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170010272 DNA binding site [nucleotide binding] 1286170010273 hypothetical protein; Provisional; Region: PRK10756 1286170010274 CreA protein; Region: CreA; pfam05981 1286170010275 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1286170010276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170010277 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1286170010278 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286170010279 catalytic core [active] 1286170010280 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1286170010281 Trp operon repressor; Provisional; Region: PRK01381 1286170010282 lytic murein transglycosylase; Provisional; Region: PRK11619 1286170010283 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286170010284 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286170010285 catalytic residue [active] 1286170010286 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1286170010287 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170010288 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170010289 ABC transporter; Region: ABC_tran_2; pfam12848 1286170010290 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170010291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170010292 non-specific DNA binding site [nucleotide binding]; other site 1286170010293 salt bridge; other site 1286170010294 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1286170010295 sequence-specific DNA binding site [nucleotide binding]; other site 1286170010296 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1286170010297 active site 1286170010298 (T/H)XGH motif; other site 1286170010299 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1286170010300 DNA repair protein RadA; Region: sms; TIGR00416 1286170010301 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1286170010302 Walker A motif/ATP binding site; other site 1286170010303 ATP binding site [chemical binding]; other site 1286170010304 Walker B motif; other site 1286170010305 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1286170010306 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1286170010307 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1286170010308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170010309 motif II; other site 1286170010310 hypothetical protein; Provisional; Region: PRK11246 1286170010311 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1286170010312 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1286170010313 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1286170010314 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1286170010315 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1286170010316 phosphopentomutase; Provisional; Region: PRK05362 1286170010317 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1286170010318 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1286170010319 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1286170010320 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1286170010321 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1286170010322 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1286170010323 intersubunit interface [polypeptide binding]; other site 1286170010324 active site 1286170010325 catalytic residue [active] 1286170010326 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1286170010327 active site 1286170010328 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1286170010329 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1286170010330 active site 1286170010331 nucleophile elbow; other site 1286170010332 periplasmic protein; Provisional; Region: PRK10568 1286170010333 BON domain; Region: BON; pfam04972 1286170010334 BON domain; Region: BON; pfam04972 1286170010335 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1286170010336 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1286170010337 G1 box; other site 1286170010338 putative GEF interaction site [polypeptide binding]; other site 1286170010339 GTP/Mg2+ binding site [chemical binding]; other site 1286170010340 Switch I region; other site 1286170010341 G2 box; other site 1286170010342 G3 box; other site 1286170010343 Switch II region; other site 1286170010344 G4 box; other site 1286170010345 G5 box; other site 1286170010346 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1286170010347 dUMP phosphatase; Provisional; Region: PRK09449 1286170010348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170010349 motif II; other site 1286170010350 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1286170010351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170010352 Coenzyme A binding pocket [chemical binding]; other site 1286170010353 DNA polymerase III subunit psi; Validated; Region: PRK06856 1286170010354 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1286170010355 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1286170010356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170010357 S-adenosylmethionine binding site [chemical binding]; other site 1286170010358 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1286170010359 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170010360 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170010361 metal binding site [ion binding]; metal-binding site 1286170010362 active site 1286170010363 I-site; other site 1286170010364 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1286170010365 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1286170010366 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1286170010367 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1286170010368 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1286170010369 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1286170010370 putative deacylase active site [active] 1286170010371 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1286170010372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170010373 DNA binding residues [nucleotide binding] 1286170010374 dimerization interface [polypeptide binding]; other site 1286170010375 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286170010376 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170010377 DNA binding residues [nucleotide binding] 1286170010378 dimerization interface [polypeptide binding]; other site 1286170010379 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1286170010380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170010381 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1286170010382 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286170010383 NAD(P) binding site [chemical binding]; other site 1286170010384 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286170010385 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1286170010386 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1286170010387 hypothetical protein; Provisional; Region: PRK09917 1286170010388 primosomal protein DnaI; Provisional; Region: PRK02854 1286170010389 DNA replication protein DnaC; Validated; Region: PRK07952 1286170010390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170010391 Walker A motif; other site 1286170010392 ATP binding site [chemical binding]; other site 1286170010393 Walker B motif; other site 1286170010394 hypothetical protein; Provisional; Region: PRK11667 1286170010395 phosphoglycerol transferase I; Provisional; Region: PRK03776 1286170010396 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1286170010397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170010398 Coenzyme A binding pocket [chemical binding]; other site 1286170010399 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1286170010400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286170010401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170010402 Coenzyme A binding pocket [chemical binding]; other site 1286170010403 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286170010404 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170010405 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170010406 putative active site [active] 1286170010407 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1286170010408 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1286170010409 active site 1286170010410 intersubunit interface [polypeptide binding]; other site 1286170010411 catalytic residue [active] 1286170010412 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1286170010413 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1286170010414 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1286170010415 Na binding site [ion binding]; other site 1286170010416 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286170010417 homotrimer interaction site [polypeptide binding]; other site 1286170010418 putative active site [active] 1286170010419 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1286170010420 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1286170010421 active site 1286170010422 putative substrate binding pocket [chemical binding]; other site 1286170010423 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1286170010424 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1286170010425 dimer interface [polypeptide binding]; other site 1286170010426 active site 1286170010427 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286170010428 substrate binding site [chemical binding]; other site 1286170010429 catalytic residue [active] 1286170010430 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1286170010431 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1286170010432 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1286170010433 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1286170010434 dimer interface [polypeptide binding]; other site 1286170010435 NADP binding site [chemical binding]; other site 1286170010436 catalytic residues [active] 1286170010437 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286170010438 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286170010439 inhibitor site; inhibition site 1286170010440 active site 1286170010441 dimer interface [polypeptide binding]; other site 1286170010442 catalytic residue [active] 1286170010443 PAS fold; Region: PAS_4; pfam08448 1286170010444 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170010445 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170010446 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 1286170010447 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1286170010448 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286170010449 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286170010450 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286170010451 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1286170010452 catalytic loop [active] 1286170010453 iron binding site [ion binding]; other site 1286170010454 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1286170010455 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1286170010456 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286170010457 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1286170010458 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1286170010459 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1286170010460 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1286170010461 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1286170010462 NAD binding site [chemical binding]; other site 1286170010463 catalytic residues [active] 1286170010464 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1286170010465 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1286170010466 putative active site [active] 1286170010467 putative metal binding site [ion binding]; other site 1286170010468 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1286170010469 putative substrate binding pocket [chemical binding]; other site 1286170010470 trimer interface [polypeptide binding]; other site 1286170010471 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1286170010472 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1286170010473 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1286170010474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170010475 putative substrate translocation pore; other site 1286170010476 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1286170010477 Cupin domain; Region: Cupin_2; pfam07883 1286170010478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170010479 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1286170010480 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1286170010481 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 1286170010482 carbon starvation protein A; Provisional; Region: PRK15015 1286170010483 Carbon starvation protein CstA; Region: CstA; pfam02554 1286170010484 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1286170010485 Uncharacterized small protein [Function unknown]; Region: COG2879 1286170010486 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1286170010487 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1286170010488 P-loop, Walker A motif; other site 1286170010489 Base recognition motif; other site 1286170010490 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1286170010491 YfaZ precursor; Region: YfaZ; pfam07437 1286170010492 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1286170010493 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1286170010494 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1286170010495 NAD(P) binding site [chemical binding]; other site 1286170010496 catalytic residues [active] 1286170010497 putative transposase; Provisional; Region: PRK09857 1286170010498 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1286170010499 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286170010500 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170010501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170010502 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286170010503 Predicted membrane protein [Function unknown]; Region: COG2733 1286170010504 cystathionine beta-lyase; Provisional; Region: PRK08114 1286170010505 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286170010506 homodimer interface [polypeptide binding]; other site 1286170010507 substrate-cofactor binding pocket; other site 1286170010508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170010509 catalytic residue [active] 1286170010510 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1286170010511 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1286170010512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170010513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170010514 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170010515 putative effector binding pocket; other site 1286170010516 dimerization interface [polypeptide binding]; other site 1286170010517 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 1286170010518 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 1286170010519 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1286170010520 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1286170010521 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 1286170010522 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1286170010523 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1286170010524 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1286170010525 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170010526 transcriptional regulator SlyA; Provisional; Region: PRK03573 1286170010527 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1286170010528 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1286170010529 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286170010530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170010531 DNA-binding site [nucleotide binding]; DNA binding site 1286170010532 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170010533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170010534 homodimer interface [polypeptide binding]; other site 1286170010535 catalytic residue [active] 1286170010536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 1286170010537 Protein of unknown function (DUF497); Region: DUF497; cl01108 1286170010538 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1286170010539 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1286170010540 dimer interface [polypeptide binding]; other site 1286170010541 Mn binding site [ion binding]; other site 1286170010542 K binding site [ion binding]; other site 1286170010543 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170010544 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170010545 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 1286170010546 putative substrate binding pocket [chemical binding]; other site 1286170010547 putative dimerization interface [polypeptide binding]; other site 1286170010548 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1286170010549 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286170010550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286170010551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170010552 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1286170010553 DNA binding site [nucleotide binding] 1286170010554 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1286170010555 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1286170010556 Hexamer interface [polypeptide binding]; other site 1286170010557 Hexagonal pore residue; other site 1286170010558 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1286170010559 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1286170010560 Hexamer interface [polypeptide binding]; other site 1286170010561 Hexagonal pore residue; other site 1286170010562 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1286170010563 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1286170010564 Hexamer interface [polypeptide binding]; other site 1286170010565 Hexagonal pore residue; other site 1286170010566 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1286170010567 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1286170010568 putative catalytic cysteine [active] 1286170010569 Ethanolamine utilisation protein EutN/carboxysome; Region: EutN_CcmL; pfam03319 1286170010570 Hexamer/Pentamer interface [polypeptide binding]; other site 1286170010571 central pore; other site 1286170010572 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1286170010573 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1286170010574 putative active site [active] 1286170010575 metal binding site [ion binding]; metal-binding site 1286170010576 Pyruvate formate lyase; Region: PFL; pfam02901 1286170010577 Pyruvate formate lyase; Region: PFL; pfam02901 1286170010578 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1286170010579 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1286170010580 dimer interface [polypeptide binding]; other site 1286170010581 active site 1286170010582 glycine loop; other site 1286170010583 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1286170010584 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286170010585 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1286170010586 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1286170010587 Hexamer interface [polypeptide binding]; other site 1286170010588 Hexagonal pore residue; other site 1286170010589 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1286170010590 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1286170010591 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1286170010592 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1286170010593 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1286170010594 tryptophanase leader peptide; Region: tnaC_leader; TIGR02616 1286170010595 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 1286170010596 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 1286170010597 substrate binding site [chemical binding]; other site 1286170010598 tetramer interface [polypeptide binding]; other site 1286170010599 catalytic residue [active] 1286170010600 tryptophan permease; Provisional; Region: PRK10483 1286170010601 aromatic amino acid transport protein; Region: araaP; TIGR00837 1286170010602 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1286170010603 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1286170010604 active site 1286170010605 HIGH motif; other site 1286170010606 dimer interface [polypeptide binding]; other site 1286170010607 KMSKS motif; other site 1286170010608 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1286170010609 heme-binding site [chemical binding]; other site 1286170010610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170010611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170010612 metal binding site [ion binding]; metal-binding site 1286170010613 active site 1286170010614 I-site; other site 1286170010615 HlyD family secretion protein; Region: HlyD; pfam00529 1286170010616 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170010617 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170010618 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286170010619 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286170010620 Walker A/P-loop; other site 1286170010621 ATP binding site [chemical binding]; other site 1286170010622 Q-loop/lid; other site 1286170010623 ABC transporter signature motif; other site 1286170010624 Walker B; other site 1286170010625 D-loop; other site 1286170010626 H-loop/switch region; other site 1286170010627 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286170010628 Walker A/P-loop; other site 1286170010629 ATP binding site [chemical binding]; other site 1286170010630 Q-loop/lid; other site 1286170010631 ABC transporter signature motif; other site 1286170010632 Walker B; other site 1286170010633 D-loop; other site 1286170010634 H-loop/switch region; other site 1286170010635 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1286170010636 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1286170010637 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1286170010638 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1286170010639 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1286170010640 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1286170010641 sensor kinase CusS; Provisional; Region: PRK09835 1286170010642 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286170010643 dimerization interface [polypeptide binding]; other site 1286170010644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170010645 dimer interface [polypeptide binding]; other site 1286170010646 phosphorylation site [posttranslational modification] 1286170010647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170010648 ATP binding site [chemical binding]; other site 1286170010649 Mg2+ binding site [ion binding]; other site 1286170010650 G-X-G motif; other site 1286170010651 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1286170010652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170010653 active site 1286170010654 phosphorylation site [posttranslational modification] 1286170010655 intermolecular recognition site; other site 1286170010656 dimerization interface [polypeptide binding]; other site 1286170010657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170010658 DNA binding site [nucleotide binding] 1286170010659 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1286170010660 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 1286170010661 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286170010662 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170010663 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1286170010664 Survival protein SurE; Region: SurE; pfam01975 1286170010665 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286170010666 catalytic core [active] 1286170010667 outer membrane porin, OprD family; Region: OprD; pfam03573 1286170010668 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1286170010669 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 1286170010670 putative active site [active] 1286170010671 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286170010672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170010673 Walker A/P-loop; other site 1286170010674 ATP binding site [chemical binding]; other site 1286170010675 Q-loop/lid; other site 1286170010676 ABC transporter signature motif; other site 1286170010677 Walker B; other site 1286170010678 D-loop; other site 1286170010679 H-loop/switch region; other site 1286170010680 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1286170010681 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170010682 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170010683 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1286170010684 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1286170010685 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1286170010686 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1286170010687 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1286170010688 PapC N-terminal domain; Region: PapC_N; pfam13954 1286170010689 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1286170010690 PapC C-terminal domain; Region: PapC_C; pfam13953 1286170010691 Fimbrial protein; Region: Fimbrial; pfam00419 1286170010692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1286170010693 DNA binding site [nucleotide binding] 1286170010694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1286170010695 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1286170010696 DNA binding site [nucleotide binding] 1286170010697 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1286170010698 active site 1 [active] 1286170010699 dimer interface [polypeptide binding]; other site 1286170010700 hexamer interface [polypeptide binding]; other site 1286170010701 active site 2 [active] 1286170010702 LysR family transcriptional regulator; Provisional; Region: PRK14997 1286170010703 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 1286170010704 putative effector binding pocket; other site 1286170010705 putative dimerization interface [polypeptide binding]; other site 1286170010706 mannonate dehydratase; Provisional; Region: PRK03906 1286170010707 mannonate dehydratase; Region: uxuA; TIGR00695 1286170010708 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1286170010709 Glucuronate isomerase; Region: UxaC; pfam02614 1286170010710 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1286170010711 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1286170010712 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1286170010713 active site residue [active] 1286170010714 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1286170010715 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286170010716 DNA-binding site [nucleotide binding]; DNA binding site 1286170010717 RNA-binding motif; other site 1286170010718 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1286170010719 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286170010720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170010721 non-specific DNA binding site [nucleotide binding]; other site 1286170010722 salt bridge; other site 1286170010723 sequence-specific DNA binding site [nucleotide binding]; other site 1286170010724 hypothetical protein; Provisional; Region: PRK13687 1286170010725 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286170010726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170010727 S-adenosylmethionine binding site [chemical binding]; other site 1286170010728 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1286170010729 xylose isomerase; Provisional; Region: PRK05474 1286170010730 xylose isomerase; Region: xylose_isom_A; TIGR02630 1286170010731 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1286170010732 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1286170010733 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1286170010734 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1286170010735 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1286170010736 inhibitor binding site; inhibition site 1286170010737 active site 1286170010738 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1286170010739 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1286170010740 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1286170010741 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 1286170010742 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1286170010743 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1286170010744 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1286170010745 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1286170010746 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1286170010747 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1286170010748 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1286170010749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1286170010750 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1286170010751 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1286170010752 ATP binding site [chemical binding]; other site 1286170010753 putative Mg++ binding site [ion binding]; other site 1286170010754 Uncharacterized conserved protein [Function unknown]; Region: COG4127 1286170010755 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1286170010756 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 1286170010757 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286170010758 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286170010759 DNA binding site [nucleotide binding] 1286170010760 active site 1286170010761 Int/Topo IB signature motif; other site 1286170010762 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1286170010763 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1286170010764 putative NAD(P) binding site [chemical binding]; other site 1286170010765 putative substrate binding site [chemical binding]; other site 1286170010766 catalytic Zn binding site [ion binding]; other site 1286170010767 structural Zn binding site [ion binding]; other site 1286170010768 dimer interface [polypeptide binding]; other site 1286170010769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170010770 dimer interface [polypeptide binding]; other site 1286170010771 conserved gate region; other site 1286170010772 putative PBP binding loops; other site 1286170010773 ABC-ATPase subunit interface; other site 1286170010774 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286170010775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170010776 dimer interface [polypeptide binding]; other site 1286170010777 conserved gate region; other site 1286170010778 putative PBP binding loops; other site 1286170010779 ABC-ATPase subunit interface; other site 1286170010780 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1286170010781 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286170010782 active site 1286170010783 metal binding site [ion binding]; metal-binding site 1286170010784 hexamer interface [polypeptide binding]; other site 1286170010785 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286170010786 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286170010787 Walker A/P-loop; other site 1286170010788 ATP binding site [chemical binding]; other site 1286170010789 Q-loop/lid; other site 1286170010790 ABC transporter signature motif; other site 1286170010791 Walker B; other site 1286170010792 D-loop; other site 1286170010793 H-loop/switch region; other site 1286170010794 TOBE domain; Region: TOBE_2; pfam08402 1286170010795 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286170010796 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286170010797 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286170010798 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286170010799 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286170010800 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1286170010801 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1286170010802 inhibitor binding site; inhibition site 1286170010803 active site 1286170010804 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1286170010805 putative symporter YagG; Provisional; Region: PRK09669 1286170010806 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1286170010807 putative dehydratase; Provisional; Region: PRK08211 1286170010808 Dehydratase family; Region: ILVD_EDD; cl00340 1286170010809 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286170010810 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286170010811 inhibitor site; inhibition site 1286170010812 active site 1286170010813 dimer interface [polypeptide binding]; other site 1286170010814 catalytic residue [active] 1286170010815 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286170010816 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1286170010817 Metal-binding active site; metal-binding site 1286170010818 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1286170010819 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1286170010820 Metal-binding active site; metal-binding site 1286170010821 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286170010822 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286170010823 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286170010824 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1286170010825 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286170010826 PYR/PP interface [polypeptide binding]; other site 1286170010827 dimer interface [polypeptide binding]; other site 1286170010828 TPP binding site [chemical binding]; other site 1286170010829 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286170010830 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1286170010831 TPP-binding site; other site 1286170010832 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170010833 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1286170010834 substrate binding site [chemical binding]; other site 1286170010835 ATP binding site [chemical binding]; other site 1286170010836 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1286170010837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1286170010838 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286170010839 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170010840 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170010841 putative active site [active] 1286170010842 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1286170010843 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1286170010844 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1286170010845 tetrameric interface [polypeptide binding]; other site 1286170010846 NAD binding site [chemical binding]; other site 1286170010847 catalytic residues [active] 1286170010848 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1286170010849 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1286170010850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1286170010851 Walker A motif; other site 1286170010852 ATP binding site [chemical binding]; other site 1286170010853 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1286170010854 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1286170010855 putative substrate binding site [chemical binding]; other site 1286170010856 nucleotide binding site [chemical binding]; other site 1286170010857 nucleotide binding site [chemical binding]; other site 1286170010858 homodimer interface [polypeptide binding]; other site 1286170010859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170010860 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170010861 putative substrate translocation pore; other site 1286170010862 membrane protein FdrA; Validated; Region: PRK06091 1286170010863 CoA binding domain; Region: CoA_binding; pfam02629 1286170010864 CoA-ligase; Region: Ligase_CoA; pfam00549 1286170010865 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1286170010866 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1286170010867 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1286170010868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170010869 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170010870 dimerization interface [polypeptide binding]; other site 1286170010871 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1286170010872 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1286170010873 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1286170010874 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1286170010875 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1286170010876 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1286170010877 interface (dimer of trimers) [polypeptide binding]; other site 1286170010878 Substrate-binding/catalytic site; other site 1286170010879 Zn-binding sites [ion binding]; other site 1286170010880 DNA polymerase III subunit chi; Validated; Region: PRK05728 1286170010881 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1286170010882 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1286170010883 HIGH motif; other site 1286170010884 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1286170010885 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1286170010886 active site 1286170010887 KMSKS motif; other site 1286170010888 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1286170010889 tRNA binding surface [nucleotide binding]; other site 1286170010890 anticodon binding site; other site 1286170010891 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1286170010892 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286170010893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170010894 Coenzyme A binding pocket [chemical binding]; other site 1286170010895 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1286170010896 active site 1286170010897 dinuclear metal binding site [ion binding]; other site 1286170010898 dimerization interface [polypeptide binding]; other site 1286170010899 RNase E inhibitor protein; Provisional; Region: PRK11191 1286170010900 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1286170010901 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1286170010902 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1286170010903 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1286170010904 PyrBI operon leader peptide; Region: PyrBI_leader; cl11578 1286170010905 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1286170010906 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1286170010907 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1286170010908 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1286170010909 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1286170010910 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1286170010911 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286170010912 homotrimer interaction site [polypeptide binding]; other site 1286170010913 putative active site [active] 1286170010914 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1286170010915 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1286170010916 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1286170010917 active site 1286170010918 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1286170010919 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1286170010920 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1286170010921 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286170010922 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1286170010923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170010924 motif II; other site 1286170010925 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1286170010926 trehalose repressor; Provisional; Region: treR; PRK09492 1286170010927 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170010928 DNA binding site [nucleotide binding] 1286170010929 domain linker motif; other site 1286170010930 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1286170010931 dimerization interface [polypeptide binding]; other site 1286170010932 ligand binding site [chemical binding]; other site 1286170010933 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1286170010934 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170010935 active site turn [active] 1286170010936 phosphorylation site [posttranslational modification] 1286170010937 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286170010938 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1286170010939 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1286170010940 Ca binding site [ion binding]; other site 1286170010941 active site 1286170010942 catalytic site [active] 1286170010943 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1286170010944 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1286170010945 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1286170010946 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1286170010947 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1286170010948 NAD binding site [chemical binding]; other site 1286170010949 sugar binding site [chemical binding]; other site 1286170010950 divalent metal binding site [ion binding]; other site 1286170010951 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286170010952 dimer interface [polypeptide binding]; other site 1286170010953 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1286170010954 active site 1286170010955 P-loop; other site 1286170010956 phosphorylation site [posttranslational modification] 1286170010957 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286170010958 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170010959 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170010960 putative active site [active] 1286170010961 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1286170010962 ATP cone domain; Region: ATP-cone; pfam03477 1286170010963 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1286170010964 effector binding site; other site 1286170010965 active site 1286170010966 Zn binding site [ion binding]; other site 1286170010967 glycine loop; other site 1286170010968 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1286170010969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170010970 FeS/SAM binding site; other site 1286170010971 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1286170010972 HTH domain; Region: HTH_11; pfam08279 1286170010973 Mga helix-turn-helix domain; Region: Mga; pfam05043 1286170010974 PRD domain; Region: PRD; pfam00874 1286170010975 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1286170010976 active site 1286170010977 P-loop; other site 1286170010978 phosphorylation site [posttranslational modification] 1286170010979 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286170010980 active site 1286170010981 phosphorylation site [posttranslational modification] 1286170010982 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1286170010983 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1286170010984 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1286170010985 dihydroorotase; Provisional; Region: PRK09237 1286170010986 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1286170010987 active site 1286170010988 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1286170010989 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1286170010990 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1286170010991 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 1286170010992 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1286170010993 cytochrome b562; Provisional; Region: PRK15058 1286170010994 peptidase PmbA; Provisional; Region: PRK11040 1286170010995 hypothetical protein; Provisional; Region: PRK05255 1286170010996 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1286170010997 active site 1286170010998 catalytic residues [active] 1286170010999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170011000 Coenzyme A binding pocket [chemical binding]; other site 1286170011001 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1286170011002 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1286170011003 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286170011004 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286170011005 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1286170011006 AMP binding site [chemical binding]; other site 1286170011007 metal binding site [ion binding]; metal-binding site 1286170011008 active site 1286170011009 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170011010 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170011011 TM-ABC transporter signature motif; other site 1286170011012 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170011013 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170011014 TM-ABC transporter signature motif; other site 1286170011015 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286170011016 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170011017 Walker A/P-loop; other site 1286170011018 ATP binding site [chemical binding]; other site 1286170011019 Q-loop/lid; other site 1286170011020 ABC transporter signature motif; other site 1286170011021 Walker B; other site 1286170011022 D-loop; other site 1286170011023 H-loop/switch region; other site 1286170011024 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170011025 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1286170011026 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286170011027 putative ligand binding site [chemical binding]; other site 1286170011028 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1286170011029 dimer interface [polypeptide binding]; other site 1286170011030 substrate binding site [chemical binding]; other site 1286170011031 metal binding sites [ion binding]; metal-binding site 1286170011032 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1286170011033 putative active site pocket [active] 1286170011034 dimerization interface [polypeptide binding]; other site 1286170011035 putative catalytic residue [active] 1286170011036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1286170011037 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1286170011038 Family of unknown function (DUF490); Region: DUF490; pfam04357 1286170011039 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1286170011040 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286170011041 Surface antigen; Region: Bac_surface_Ag; pfam01103 1286170011042 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1286170011043 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1286170011044 Domain of unknown function DUF21; Region: DUF21; pfam01595 1286170011045 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1286170011046 Transporter associated domain; Region: CorC_HlyC; smart01091 1286170011047 galactoside permease; Reviewed; Region: lacY; PRK09528 1286170011048 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1286170011049 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1286170011050 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1286170011051 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1286170011052 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286170011053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170011054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170011055 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1286170011056 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1286170011057 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1286170011058 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286170011059 active site 1286170011060 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1286170011061 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1286170011062 active site 1286170011063 metal binding site [ion binding]; metal-binding site 1286170011064 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1286170011065 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286170011066 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286170011067 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1286170011068 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1286170011069 NADP binding site [chemical binding]; other site 1286170011070 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286170011071 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170011072 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170011073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170011074 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286170011075 EamA-like transporter family; Region: EamA; pfam00892 1286170011076 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1286170011077 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1286170011078 Hemerythrin-like domain; Region: Hr-like; cd12108 1286170011079 Fe binding site [ion binding]; other site 1286170011080 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1286170011081 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1286170011082 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1286170011083 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1286170011084 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1286170011085 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1286170011086 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1286170011087 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1286170011088 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1286170011089 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1286170011090 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1286170011091 dimer interface [polypeptide binding]; other site 1286170011092 ssDNA binding site [nucleotide binding]; other site 1286170011093 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286170011094 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1286170011095 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1286170011096 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1286170011097 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1286170011098 intersubunit interface [polypeptide binding]; other site 1286170011099 active site 1286170011100 Zn2+ binding site [ion binding]; other site 1286170011101 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1286170011102 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1286170011103 AP (apurinic/apyrimidinic) site pocket; other site 1286170011104 DNA interaction; other site 1286170011105 Metal-binding active site; metal-binding site 1286170011106 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1286170011107 active site 1286170011108 dimer interface [polypeptide binding]; other site 1286170011109 magnesium binding site [ion binding]; other site 1286170011110 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286170011111 active site 1286170011112 phosphorylation site [posttranslational modification] 1286170011113 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1286170011114 active site 1286170011115 P-loop; other site 1286170011116 phosphorylation site [posttranslational modification] 1286170011117 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1286170011118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1286170011119 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1286170011120 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1286170011121 transcriptional repressor UlaR; Provisional; Region: PRK13509 1286170011122 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1286170011123 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286170011124 esterase; Provisional; Region: PRK10566 1286170011125 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286170011126 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1286170011127 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1286170011128 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1286170011129 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1286170011130 FAD binding site [chemical binding]; other site 1286170011131 substrate binding site [chemical binding]; other site 1286170011132 catalytic residues [active] 1286170011133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170011134 metabolite-proton symporter; Region: 2A0106; TIGR00883 1286170011135 putative substrate translocation pore; other site 1286170011136 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1286170011137 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1286170011138 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1286170011139 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286170011140 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286170011141 Walker A/P-loop; other site 1286170011142 ATP binding site [chemical binding]; other site 1286170011143 Q-loop/lid; other site 1286170011144 ABC transporter signature motif; other site 1286170011145 Walker B; other site 1286170011146 D-loop; other site 1286170011147 H-loop/switch region; other site 1286170011148 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286170011149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170011150 dimer interface [polypeptide binding]; other site 1286170011151 conserved gate region; other site 1286170011152 putative PBP binding loops; other site 1286170011153 ABC-ATPase subunit interface; other site 1286170011154 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1286170011155 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170011156 substrate binding pocket [chemical binding]; other site 1286170011157 membrane-bound complex binding site; other site 1286170011158 aspartate racemase; Region: asp_race; TIGR00035 1286170011159 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1286170011160 D-cysteine desulfhydrase; Validated; Region: PRK03910 1286170011161 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1286170011162 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286170011163 catalytic residue [active] 1286170011164 exoribonuclease R; Provisional; Region: PRK11642 1286170011165 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1286170011166 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1286170011167 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1286170011168 RNB domain; Region: RNB; pfam00773 1286170011169 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1286170011170 RNA binding site [nucleotide binding]; other site 1286170011171 Predicted transcriptional regulator [Transcription]; Region: COG1959 1286170011172 transcriptional repressor NsrR; Provisional; Region: PRK11014 1286170011173 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1286170011174 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1286170011175 GDP-binding site [chemical binding]; other site 1286170011176 ACT binding site; other site 1286170011177 IMP binding site; other site 1286170011178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1286170011179 FtsH protease regulator HflC; Provisional; Region: PRK11029 1286170011180 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1286170011181 FtsH protease regulator HflK; Provisional; Region: PRK10930 1286170011182 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1286170011183 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1286170011184 GTPase HflX; Provisional; Region: PRK11058 1286170011185 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1286170011186 HflX GTPase family; Region: HflX; cd01878 1286170011187 G1 box; other site 1286170011188 GTP/Mg2+ binding site [chemical binding]; other site 1286170011189 Switch I region; other site 1286170011190 G2 box; other site 1286170011191 G3 box; other site 1286170011192 Switch II region; other site 1286170011193 G4 box; other site 1286170011194 G5 box; other site 1286170011195 bacterial Hfq-like; Region: Hfq; cd01716 1286170011196 hexamer interface [polypeptide binding]; other site 1286170011197 Sm1 motif; other site 1286170011198 RNA binding site [nucleotide binding]; other site 1286170011199 Sm2 motif; other site 1286170011200 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1286170011201 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1286170011202 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1286170011203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170011204 ATP binding site [chemical binding]; other site 1286170011205 Mg2+ binding site [ion binding]; other site 1286170011206 G-X-G motif; other site 1286170011207 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1286170011208 ATP binding site [chemical binding]; other site 1286170011209 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1286170011210 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1286170011211 AMIN domain; Region: AMIN; pfam11741 1286170011212 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1286170011213 active site 1286170011214 metal binding site [ion binding]; metal-binding site 1286170011215 ADP-binding protein; Provisional; Region: PRK10646 1286170011216 putative carbohydrate kinase; Provisional; Region: PRK10565 1286170011217 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1286170011218 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1286170011219 putative substrate binding site [chemical binding]; other site 1286170011220 putative ATP binding site [chemical binding]; other site 1286170011221 epoxyqueuosine reductase; Region: TIGR00276 1286170011222 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1286170011223 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170011224 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170011225 substrate binding pocket [chemical binding]; other site 1286170011226 membrane-bound complex binding site; other site 1286170011227 hinge residues; other site 1286170011228 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1286170011229 catalytic site [active] 1286170011230 putative active site [active] 1286170011231 putative substrate binding site [chemical binding]; other site 1286170011232 dimer interface [polypeptide binding]; other site 1286170011233 GTPase RsgA; Reviewed; Region: PRK12288 1286170011234 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1286170011235 RNA binding site [nucleotide binding]; other site 1286170011236 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1286170011237 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1286170011238 GTP/Mg2+ binding site [chemical binding]; other site 1286170011239 G4 box; other site 1286170011240 G5 box; other site 1286170011241 G1 box; other site 1286170011242 Switch I region; other site 1286170011243 G2 box; other site 1286170011244 G3 box; other site 1286170011245 Switch II region; other site 1286170011246 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1286170011247 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1286170011248 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1286170011249 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286170011250 poxB regulator PoxA; Provisional; Region: PRK09350 1286170011251 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1286170011252 motif 1; other site 1286170011253 dimer interface [polypeptide binding]; other site 1286170011254 active site 1286170011255 motif 2; other site 1286170011256 motif 3; other site 1286170011257 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1286170011258 L-aspartate oxidase; Provisional; Region: PRK06175 1286170011259 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1286170011260 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1286170011261 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1286170011262 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1286170011263 D-subunit interface [polypeptide binding]; other site 1286170011264 Iron-sulfur protein interface; other site 1286170011265 proximal quinone binding site [chemical binding]; other site 1286170011266 distal quinone binding site [chemical binding]; other site 1286170011267 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1286170011268 Iron-sulfur protein interface; other site 1286170011269 proximal quinone binding site [chemical binding]; other site 1286170011270 C-subunit interface; other site 1286170011271 distal quinone binding site; other site 1286170011272 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1286170011273 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1286170011274 multidrug efflux system protein; Provisional; Region: PRK11431 1286170011275 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1286170011276 Predicted small secreted protein [Function unknown]; Region: COG5510 1286170011277 elongation factor P; Validated; Region: PRK00529 1286170011278 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1286170011279 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1286170011280 RNA binding site [nucleotide binding]; other site 1286170011281 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1286170011282 RNA binding site [nucleotide binding]; other site 1286170011283 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1286170011284 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170011285 FeS/SAM binding site; other site 1286170011286 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1286170011287 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1286170011288 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1286170011289 ring oligomerisation interface [polypeptide binding]; other site 1286170011290 ATP/Mg binding site [chemical binding]; other site 1286170011291 stacking interactions; other site 1286170011292 hinge regions; other site 1286170011293 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1286170011294 oligomerisation interface [polypeptide binding]; other site 1286170011295 mobile loop; other site 1286170011296 roof hairpin; other site 1286170011297 putative transporter; Provisional; Region: PRK11021 1286170011298 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1286170011299 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1286170011300 Aspartase; Region: Aspartase; cd01357 1286170011301 active sites [active] 1286170011302 tetramer interface [polypeptide binding]; other site 1286170011303 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1286170011304 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1286170011305 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1286170011306 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1286170011307 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1286170011308 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1286170011309 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1286170011310 DsbD alpha interface [polypeptide binding]; other site 1286170011311 catalytic residues [active] 1286170011312 putative transcriptional regulator; Provisional; Region: PRK11640 1286170011313 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1286170011314 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1286170011315 D-cysteine desulfhydrase; Validated; Region: PRK03910 1286170011316 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1286170011317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170011318 catalytic residue [active] 1286170011319 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286170011320 homotrimer interaction site [polypeptide binding]; other site 1286170011321 putative active site [active] 1286170011322 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1286170011323 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286170011324 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1286170011325 homodimer interface [polypeptide binding]; other site 1286170011326 substrate-cofactor binding pocket; other site 1286170011327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170011328 catalytic residue [active] 1286170011329 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1286170011330 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1286170011331 catalytic residues [active] 1286170011332 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1286170011333 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1286170011334 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1286170011335 HSP70 interaction site [polypeptide binding]; other site 1286170011336 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1286170011337 substrate binding site [polypeptide binding]; other site 1286170011338 dimer interface [polypeptide binding]; other site 1286170011339 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1286170011340 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1286170011341 alpha-galactosidase; Provisional; Region: PRK15076 1286170011342 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1286170011343 NAD binding site [chemical binding]; other site 1286170011344 sugar binding site [chemical binding]; other site 1286170011345 divalent metal binding site [ion binding]; other site 1286170011346 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286170011347 dimer interface [polypeptide binding]; other site 1286170011348 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1286170011349 proline/glycine betaine transporter; Provisional; Region: PRK10642 1286170011350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170011351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170011352 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1286170011353 hypothetical protein; Provisional; Region: PRK10220 1286170011354 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1286170011355 PhnA protein; Region: PhnA; pfam03831 1286170011356 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1286170011357 dimer interface [polypeptide binding]; other site 1286170011358 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286170011359 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1286170011360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170011361 DNA-binding site [nucleotide binding]; DNA binding site 1286170011362 UTRA domain; Region: UTRA; pfam07702 1286170011363 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1286170011364 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 1286170011365 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 1286170011366 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1286170011367 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1286170011368 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170011369 Walker A/P-loop; other site 1286170011370 ATP binding site [chemical binding]; other site 1286170011371 Q-loop/lid; other site 1286170011372 ABC transporter signature motif; other site 1286170011373 Walker B; other site 1286170011374 D-loop; other site 1286170011375 H-loop/switch region; other site 1286170011376 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286170011377 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1286170011378 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286170011379 Walker A/P-loop; other site 1286170011380 ATP binding site [chemical binding]; other site 1286170011381 Q-loop/lid; other site 1286170011382 ABC transporter signature motif; other site 1286170011383 Walker B; other site 1286170011384 D-loop; other site 1286170011385 H-loop/switch region; other site 1286170011386 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1286170011387 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286170011388 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1286170011389 active site 1286170011390 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 1286170011391 active site 1286170011392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170011393 Coenzyme A binding pocket [chemical binding]; other site 1286170011394 putative hydrolase; Provisional; Region: PRK02113 1286170011395 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1286170011396 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1286170011397 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 1286170011398 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170011399 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170011400 putative active site [active] 1286170011401 D-allose transporter subunit; Provisional; Region: PRK09701 1286170011402 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 1286170011403 ligand binding site [chemical binding]; other site 1286170011404 dimerization interface [polypeptide binding]; other site 1286170011405 zinc binding site [ion binding]; other site 1286170011406 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 1286170011407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170011408 Walker A/P-loop; other site 1286170011409 ATP binding site [chemical binding]; other site 1286170011410 Q-loop/lid; other site 1286170011411 ABC transporter signature motif; other site 1286170011412 Walker B; other site 1286170011413 D-loop; other site 1286170011414 H-loop/switch region; other site 1286170011415 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170011416 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170011417 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170011418 TM-ABC transporter signature motif; other site 1286170011419 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1286170011420 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1286170011421 substrate binding site [chemical binding]; other site 1286170011422 hexamer interface [polypeptide binding]; other site 1286170011423 metal binding site [ion binding]; metal-binding site 1286170011424 D-allose kinase; Provisional; Region: PRK09698 1286170011425 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286170011426 nucleotide binding site [chemical binding]; other site 1286170011427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286170011428 dimerization interface [polypeptide binding]; other site 1286170011429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286170011430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170011431 dimer interface [polypeptide binding]; other site 1286170011432 phosphorylation site [posttranslational modification] 1286170011433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170011434 ATP binding site [chemical binding]; other site 1286170011435 Mg2+ binding site [ion binding]; other site 1286170011436 G-X-G motif; other site 1286170011437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170011438 Response regulator receiver domain; Region: Response_reg; pfam00072 1286170011439 active site 1286170011440 phosphorylation site [posttranslational modification] 1286170011441 intermolecular recognition site; other site 1286170011442 dimerization interface [polypeptide binding]; other site 1286170011443 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286170011444 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170011445 Walker A/P-loop; other site 1286170011446 ATP binding site [chemical binding]; other site 1286170011447 Q-loop/lid; other site 1286170011448 ABC transporter signature motif; other site 1286170011449 Walker B; other site 1286170011450 D-loop; other site 1286170011451 H-loop/switch region; other site 1286170011452 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170011453 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170011454 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170011455 TM-ABC transporter signature motif; other site 1286170011456 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286170011457 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1286170011458 putative ligand binding site [chemical binding]; other site 1286170011459 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286170011460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170011461 active site 1286170011462 phosphorylation site [posttranslational modification] 1286170011463 intermolecular recognition site; other site 1286170011464 dimerization interface [polypeptide binding]; other site 1286170011465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170011466 DNA binding site [nucleotide binding] 1286170011467 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170011468 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170011469 molybdopterin cofactor binding site; other site 1286170011470 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1286170011471 molybdopterin cofactor binding site; other site 1286170011472 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1286170011473 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1286170011474 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1286170011475 acetyl-CoA synthetase; Provisional; Region: PRK00174 1286170011476 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1286170011477 active site 1286170011478 CoA binding site [chemical binding]; other site 1286170011479 acyl-activating enzyme (AAE) consensus motif; other site 1286170011480 AMP binding site [chemical binding]; other site 1286170011481 acetate binding site [chemical binding]; other site 1286170011482 Predicted membrane protein [Function unknown]; Region: COG3162 1286170011483 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1286170011484 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1286170011485 Na binding site [ion binding]; other site 1286170011486 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1286170011487 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1286170011488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170011489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170011490 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1286170011491 putative dimerization interface [polypeptide binding]; other site 1286170011492 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1286170011493 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1286170011494 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1286170011495 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286170011496 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1286170011497 putative C-terminal domain interface [polypeptide binding]; other site 1286170011498 putative GSH binding site (G-site) [chemical binding]; other site 1286170011499 putative dimer interface [polypeptide binding]; other site 1286170011500 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1286170011501 putative N-terminal domain interface [polypeptide binding]; other site 1286170011502 putative dimer interface [polypeptide binding]; other site 1286170011503 putative substrate binding pocket (H-site) [chemical binding]; other site 1286170011504 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1286170011505 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1286170011506 DNA binding residues [nucleotide binding] 1286170011507 dimer interface [polypeptide binding]; other site 1286170011508 [2Fe-2S] cluster binding site [ion binding]; other site 1286170011509 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1286170011510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170011511 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1286170011512 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1286170011513 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170011514 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1286170011515 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1286170011516 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286170011517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170011518 DNA binding residues [nucleotide binding] 1286170011519 dimerization interface [polypeptide binding]; other site 1286170011520 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1286170011521 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286170011522 DNA binding site [nucleotide binding] 1286170011523 anti-adapter protein IraM; Provisional; Region: PRK09919 1286170011524 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1286170011525 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286170011526 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286170011527 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286170011528 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286170011529 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286170011530 Surface antigen; Region: Bac_surface_Ag; pfam01103 1286170011531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170011532 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170011533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170011534 outer membrane receptor FepA; Provisional; Region: PRK13524 1286170011535 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170011536 N-terminal plug; other site 1286170011537 ligand-binding site [chemical binding]; other site 1286170011538 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 1286170011539 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170011540 substrate binding pocket [chemical binding]; other site 1286170011541 membrane-bound complex binding site; other site 1286170011542 hinge residues; other site 1286170011543 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286170011544 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286170011545 catalytic residue [active] 1286170011546 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1286170011547 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1286170011548 dimer interface [polypeptide binding]; other site 1286170011549 ssDNA binding site [nucleotide binding]; other site 1286170011550 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286170011551 putative single-stranded DNA-binding protein; Region: PHA01740 1286170011552 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1286170011553 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1286170011554 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1286170011555 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1286170011556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1286170011557 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1286170011558 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1286170011559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170011560 active site 1286170011561 motif I; other site 1286170011562 motif II; other site 1286170011563 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1286170011564 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170011565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170011566 homodimer interface [polypeptide binding]; other site 1286170011567 catalytic residue [active] 1286170011568 alanine racemase; Reviewed; Region: alr; PRK00053 1286170011569 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1286170011570 active site 1286170011571 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286170011572 substrate binding site [chemical binding]; other site 1286170011573 catalytic residues [active] 1286170011574 dimer interface [polypeptide binding]; other site 1286170011575 replicative DNA helicase; Provisional; Region: PRK08006 1286170011576 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1286170011577 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1286170011578 Walker A motif; other site 1286170011579 ATP binding site [chemical binding]; other site 1286170011580 Walker B motif; other site 1286170011581 DNA binding loops [nucleotide binding] 1286170011582 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1286170011583 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1286170011584 NADP binding site [chemical binding]; other site 1286170011585 dimer interface [polypeptide binding]; other site 1286170011586 phage shock protein G; Reviewed; Region: pspG; PRK09459 1286170011587 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1286170011588 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1286170011589 FMN binding site [chemical binding]; other site 1286170011590 active site 1286170011591 catalytic residues [active] 1286170011592 substrate binding site [chemical binding]; other site 1286170011593 Cupin domain; Region: Cupin_2; cl17218 1286170011594 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1286170011595 metal binding site 2 [ion binding]; metal-binding site 1286170011596 putative DNA binding helix; other site 1286170011597 metal binding site 1 [ion binding]; metal-binding site 1286170011598 dimer interface [polypeptide binding]; other site 1286170011599 structural Zn2+ binding site [ion binding]; other site 1286170011600 hypothetical protein; Provisional; Region: PRK10428 1286170011601 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1286170011602 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1286170011603 LexA repressor; Validated; Region: PRK00215 1286170011604 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1286170011605 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1286170011606 Catalytic site [active] 1286170011607 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1286170011608 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1286170011609 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1286170011610 putative acyl-acceptor binding pocket; other site 1286170011611 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1286170011612 UbiA prenyltransferase family; Region: UbiA; pfam01040 1286170011613 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1286170011614 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1286170011615 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1286170011616 trimer interface; other site 1286170011617 sugar binding site [chemical binding]; other site 1286170011618 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1286170011619 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286170011620 Walker A/P-loop; other site 1286170011621 ATP binding site [chemical binding]; other site 1286170011622 Q-loop/lid; other site 1286170011623 ABC transporter signature motif; other site 1286170011624 Walker B; other site 1286170011625 D-loop; other site 1286170011626 H-loop/switch region; other site 1286170011627 TOBE domain; Region: TOBE_2; pfam08402 1286170011628 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1286170011629 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286170011630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170011631 dimer interface [polypeptide binding]; other site 1286170011632 conserved gate region; other site 1286170011633 putative PBP binding loops; other site 1286170011634 ABC-ATPase subunit interface; other site 1286170011635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286170011636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170011637 dimer interface [polypeptide binding]; other site 1286170011638 conserved gate region; other site 1286170011639 putative PBP binding loops; other site 1286170011640 ABC-ATPase subunit interface; other site 1286170011641 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1286170011642 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286170011643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170011644 Coenzyme A binding pocket [chemical binding]; other site 1286170011645 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1286170011646 putative trimer interface [polypeptide binding]; other site 1286170011647 putative active site [active] 1286170011648 putative substrate binding site [chemical binding]; other site 1286170011649 putative CoA binding site [chemical binding]; other site 1286170011650 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1286170011651 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1286170011652 active site 1286170011653 dimer interface [polypeptide binding]; other site 1286170011654 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1286170011655 dimer interface [polypeptide binding]; other site 1286170011656 active site 1286170011657 aspartate kinase III; Validated; Region: PRK09084 1286170011658 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1286170011659 nucleotide binding site [chemical binding]; other site 1286170011660 substrate binding site [chemical binding]; other site 1286170011661 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1286170011662 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1286170011663 dimer interface [polypeptide binding]; other site 1286170011664 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1286170011665 Sodium Bile acid symporter family; Region: SBF; pfam01758 1286170011666 hypothetical protein; Provisional; Region: PRK10515 1286170011667 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1286170011668 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286170011669 RNA binding surface [nucleotide binding]; other site 1286170011670 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1286170011671 probable active site [active] 1286170011672 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286170011673 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286170011674 DNA binding residues [nucleotide binding] 1286170011675 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286170011676 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 1286170011677 classical (c) SDRs; Region: SDR_c; cd05233 1286170011678 NAD(P) binding site [chemical binding]; other site 1286170011679 active site 1286170011680 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1286170011681 active pocket/dimerization site; other site 1286170011682 active site 1286170011683 phosphorylation site [posttranslational modification] 1286170011684 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1286170011685 active site 1286170011686 phosphorylation site [posttranslational modification] 1286170011687 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1286170011688 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1286170011689 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1286170011690 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286170011691 putative NAD(P) binding site [chemical binding]; other site 1286170011692 catalytic Zn binding site [ion binding]; other site 1286170011693 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1286170011694 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1286170011695 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1286170011696 shikimate binding site; other site 1286170011697 NAD(P) binding site [chemical binding]; other site 1286170011698 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1286170011699 active site pocket [active] 1286170011700 oxyanion hole [active] 1286170011701 catalytic triad [active] 1286170011702 active site nucleophile [active] 1286170011703 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1286170011704 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1286170011705 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1286170011706 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1286170011707 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1286170011708 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1286170011709 substrate binding pocket [chemical binding]; other site 1286170011710 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1286170011711 B12 binding site [chemical binding]; other site 1286170011712 cobalt ligand [ion binding]; other site 1286170011713 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1286170011714 transcriptional repressor IclR; Provisional; Region: PRK11569 1286170011715 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286170011716 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286170011717 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1286170011718 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1286170011719 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1286170011720 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1286170011721 isocitrate lyase; Provisional; Region: PRK15063 1286170011722 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1286170011723 tetramer interface [polypeptide binding]; other site 1286170011724 active site 1286170011725 Mg2+/Mn2+ binding site [ion binding]; other site 1286170011726 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1286170011727 malate synthase A; Region: malate_syn_A; TIGR01344 1286170011728 active site 1286170011729 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1286170011730 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1286170011731 proposed active site lysine [active] 1286170011732 conserved cys residue [active] 1286170011733 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286170011734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170011735 Coenzyme A binding pocket [chemical binding]; other site 1286170011736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286170011737 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1286170011738 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1286170011739 purine monophosphate binding site [chemical binding]; other site 1286170011740 dimer interface [polypeptide binding]; other site 1286170011741 putative catalytic residues [active] 1286170011742 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1286170011743 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1286170011744 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1286170011745 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1286170011746 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1286170011747 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1286170011748 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1286170011749 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286170011750 IHF dimer interface [polypeptide binding]; other site 1286170011751 IHF - DNA interface [nucleotide binding]; other site 1286170011752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1286170011753 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1286170011754 Active_site [active] 1286170011755 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1286170011756 substrate binding site [chemical binding]; other site 1286170011757 active site 1286170011758 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1286170011759 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1286170011760 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1286170011761 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1286170011762 putative NADH binding site [chemical binding]; other site 1286170011763 putative active site [active] 1286170011764 nudix motif; other site 1286170011765 putative metal binding site [ion binding]; other site 1286170011766 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1286170011767 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1286170011768 ThiC-associated domain; Region: ThiC-associated; pfam13667 1286170011769 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1286170011770 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1286170011771 thiamine phosphate binding site [chemical binding]; other site 1286170011772 active site 1286170011773 pyrophosphate binding site [ion binding]; other site 1286170011774 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1286170011775 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1286170011776 ATP binding site [chemical binding]; other site 1286170011777 substrate interface [chemical binding]; other site 1286170011778 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1286170011779 thiS-thiF/thiG interaction site; other site 1286170011780 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1286170011781 ThiS interaction site; other site 1286170011782 putative active site [active] 1286170011783 tetramer interface [polypeptide binding]; other site 1286170011784 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1286170011785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170011786 FeS/SAM binding site; other site 1286170011787 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1286170011788 Cache domain; Region: Cache_1; pfam02743 1286170011789 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286170011790 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170011791 metal binding site [ion binding]; metal-binding site 1286170011792 active site 1286170011793 I-site; other site 1286170011794 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1286170011795 active site 1286170011796 P-loop; other site 1286170011797 phosphorylation site [posttranslational modification] 1286170011798 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1286170011799 methionine cluster; other site 1286170011800 active site 1286170011801 phosphorylation site [posttranslational modification] 1286170011802 metal binding site [ion binding]; metal-binding site 1286170011803 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1286170011804 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1286170011805 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1286170011806 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1286170011807 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1286170011808 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1286170011809 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1286170011810 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1286170011811 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1286170011812 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1286170011813 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1286170011814 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1286170011815 DNA binding site [nucleotide binding] 1286170011816 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1286170011817 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1286170011818 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1286170011819 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1286170011820 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1286170011821 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1286170011822 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1286170011823 RPB3 interaction site [polypeptide binding]; other site 1286170011824 RPB1 interaction site [polypeptide binding]; other site 1286170011825 RPB11 interaction site [polypeptide binding]; other site 1286170011826 RPB10 interaction site [polypeptide binding]; other site 1286170011827 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1286170011828 core dimer interface [polypeptide binding]; other site 1286170011829 peripheral dimer interface [polypeptide binding]; other site 1286170011830 L10 interface [polypeptide binding]; other site 1286170011831 L11 interface [polypeptide binding]; other site 1286170011832 putative EF-Tu interaction site [polypeptide binding]; other site 1286170011833 putative EF-G interaction site [polypeptide binding]; other site 1286170011834 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1286170011835 23S rRNA interface [nucleotide binding]; other site 1286170011836 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1286170011837 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1286170011838 mRNA/rRNA interface [nucleotide binding]; other site 1286170011839 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1286170011840 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1286170011841 23S rRNA interface [nucleotide binding]; other site 1286170011842 L7/L12 interface [polypeptide binding]; other site 1286170011843 putative thiostrepton binding site; other site 1286170011844 L25 interface [polypeptide binding]; other site 1286170011845 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1286170011846 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1286170011847 putative homodimer interface [polypeptide binding]; other site 1286170011848 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1286170011849 heterodimer interface [polypeptide binding]; other site 1286170011850 homodimer interface [polypeptide binding]; other site 1286170011851 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1286170011852 elongation factor Tu; Reviewed; Region: PRK00049 1286170011853 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1286170011854 G1 box; other site 1286170011855 GEF interaction site [polypeptide binding]; other site 1286170011856 GTP/Mg2+ binding site [chemical binding]; other site 1286170011857 Switch I region; other site 1286170011858 G2 box; other site 1286170011859 G3 box; other site 1286170011860 Switch II region; other site 1286170011861 G4 box; other site 1286170011862 G5 box; other site 1286170011863 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1286170011864 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1286170011865 Antibiotic Binding Site [chemical binding]; other site 1286170011866 potential protein location (hypothetical protein RORB6_17640 [Raoultella ornithinolytica B6]) that overlaps RNA (tRNA-G) 1286170011867 potential protein location (hypothetical protein RORB6_17640 [Raoultella ornithinolytica B6]) that overlaps RNA (tRNA-T) 1286170011868 pantothenate kinase; Provisional; Region: PRK05439 1286170011869 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1286170011870 ATP-binding site [chemical binding]; other site 1286170011871 CoA-binding site [chemical binding]; other site 1286170011872 Mg2+-binding site [ion binding]; other site 1286170011873 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1286170011874 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1286170011875 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1286170011876 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1286170011877 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1286170011878 FAD binding domain; Region: FAD_binding_4; pfam01565 1286170011879 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1286170011880 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1286170011881 potassium transporter; Provisional; Region: PRK10750 1286170011882 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1286170011883 hypothetical protein; Provisional; Region: PRK11568 1286170011884 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1286170011885 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1286170011886 proline dipeptidase; Provisional; Region: PRK13607 1286170011887 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1286170011888 active site 1286170011889 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1286170011890 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286170011891 substrate binding site [chemical binding]; other site 1286170011892 oxyanion hole (OAH) forming residues; other site 1286170011893 trimer interface [polypeptide binding]; other site 1286170011894 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1286170011895 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286170011896 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286170011897 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1286170011898 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286170011899 dimer interface [polypeptide binding]; other site 1286170011900 active site 1286170011901 FMN reductase; Validated; Region: fre; PRK08051 1286170011902 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1286170011903 FAD binding pocket [chemical binding]; other site 1286170011904 FAD binding motif [chemical binding]; other site 1286170011905 phosphate binding motif [ion binding]; other site 1286170011906 beta-alpha-beta structure motif; other site 1286170011907 NAD binding pocket [chemical binding]; other site 1286170011908 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1286170011909 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1286170011910 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1286170011911 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1286170011912 active site 1286170011913 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1286170011914 sec-independent translocase; Provisional; Region: PRK01770 1286170011915 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1286170011916 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1286170011917 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1286170011918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1286170011919 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1286170011920 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1286170011921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170011922 S-adenosylmethionine binding site [chemical binding]; other site 1286170011923 DNA recombination protein RmuC; Provisional; Region: PRK10361 1286170011924 RmuC family; Region: RmuC; pfam02646 1286170011925 uridine phosphorylase; Provisional; Region: PRK11178 1286170011926 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1286170011927 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1286170011928 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170011929 substrate binding pocket [chemical binding]; other site 1286170011930 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170011931 membrane-bound complex binding site; other site 1286170011932 hinge residues; other site 1286170011933 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1286170011934 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1286170011935 THF binding site; other site 1286170011936 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1286170011937 substrate binding site [chemical binding]; other site 1286170011938 THF binding site; other site 1286170011939 zinc-binding site [ion binding]; other site 1286170011940 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1286170011941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170011942 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1286170011943 putative dimerization interface [polypeptide binding]; other site 1286170011944 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286170011945 EamA-like transporter family; Region: EamA; pfam00892 1286170011946 putative hydrolase; Provisional; Region: PRK10976 1286170011947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170011948 active site 1286170011949 motif I; other site 1286170011950 motif II; other site 1286170011951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170011952 lysophospholipase L2; Provisional; Region: PRK10749 1286170011953 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286170011954 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1286170011955 threonine efflux system; Provisional; Region: PRK10229 1286170011956 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1286170011957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286170011958 ATP binding site [chemical binding]; other site 1286170011959 putative Mg++ binding site [ion binding]; other site 1286170011960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170011961 nucleotide binding region [chemical binding]; other site 1286170011962 ATP-binding site [chemical binding]; other site 1286170011963 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1286170011964 HRDC domain; Region: HRDC; pfam00570 1286170011965 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1286170011966 dimerization interface [polypeptide binding]; other site 1286170011967 substrate binding site [chemical binding]; other site 1286170011968 active site 1286170011969 calcium binding site [ion binding]; other site 1286170011970 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1286170011971 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1286170011972 CoenzymeA binding site [chemical binding]; other site 1286170011973 subunit interaction site [polypeptide binding]; other site 1286170011974 PHB binding site; other site 1286170011975 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1286170011976 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1286170011977 putative catalytic site [active] 1286170011978 putative metal binding site [ion binding]; other site 1286170011979 putative phosphate binding site [ion binding]; other site 1286170011980 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1286170011981 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1286170011982 Cl binding site [ion binding]; other site 1286170011983 oligomer interface [polypeptide binding]; other site 1286170011984 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1286170011985 Part of AAA domain; Region: AAA_19; pfam13245 1286170011986 Family description; Region: UvrD_C_2; pfam13538 1286170011987 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1286170011988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170011989 motif II; other site 1286170011990 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1286170011991 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1286170011992 active site 1286170011993 Int/Topo IB signature motif; other site 1286170011994 hypothetical protein; Provisional; Region: PRK10963 1286170011995 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1286170011996 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1286170011997 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1286170011998 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1286170011999 hypothetical protein; Provisional; Region: PRK09807 1286170012000 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1286170012001 putative iron binding site [ion binding]; other site 1286170012002 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1286170012003 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1286170012004 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1286170012005 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1286170012006 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1286170012007 domain interfaces; other site 1286170012008 active site 1286170012009 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1286170012010 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1286170012011 active site 1286170012012 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1286170012013 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1286170012014 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1286170012015 HemY protein N-terminus; Region: HemY_N; pfam07219 1286170012016 Tetratricopeptide repeat; Region: TPR_2; pfam07719 1286170012017 putative transport protein YifK; Provisional; Region: PRK10746 1286170012018 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1286170012019 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1286170012020 putative common antigen polymerase; Provisional; Region: PRK02975 1286170012021 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1286170012022 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1286170012023 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1286170012024 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1286170012025 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1286170012026 inhibitor-cofactor binding pocket; inhibition site 1286170012027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170012028 catalytic residue [active] 1286170012029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286170012030 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1286170012031 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1286170012032 substrate binding site; other site 1286170012033 tetramer interface; other site 1286170012034 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1286170012035 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1286170012036 NAD binding site [chemical binding]; other site 1286170012037 substrate binding site [chemical binding]; other site 1286170012038 homodimer interface [polypeptide binding]; other site 1286170012039 active site 1286170012040 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1286170012041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1286170012042 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1286170012043 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1286170012044 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1286170012045 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1286170012046 active site 1286170012047 homodimer interface [polypeptide binding]; other site 1286170012048 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1286170012049 Chain length determinant protein; Region: Wzz; pfam02706 1286170012050 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1286170012051 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1286170012052 Mg++ binding site [ion binding]; other site 1286170012053 putative catalytic motif [active] 1286170012054 substrate binding site [chemical binding]; other site 1286170012055 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1286170012056 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1286170012057 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1286170012058 RNA binding site [nucleotide binding]; other site 1286170012059 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1286170012060 multimer interface [polypeptide binding]; other site 1286170012061 Walker A motif; other site 1286170012062 ATP binding site [chemical binding]; other site 1286170012063 Walker B motif; other site 1286170012064 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286170012065 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286170012066 catalytic residues [active] 1286170012067 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1286170012068 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1286170012069 ATP binding site [chemical binding]; other site 1286170012070 Mg++ binding site [ion binding]; other site 1286170012071 motif III; other site 1286170012072 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170012073 nucleotide binding region [chemical binding]; other site 1286170012074 ATP-binding site [chemical binding]; other site 1286170012075 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1286170012076 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1286170012077 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1286170012078 Part of AAA domain; Region: AAA_19; pfam13245 1286170012079 Family description; Region: UvrD_C_2; pfam13538 1286170012080 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1286170012081 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1286170012082 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1286170012083 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1286170012084 ketol-acid reductoisomerase; Validated; Region: PRK05225 1286170012085 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1286170012086 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1286170012087 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1286170012088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170012089 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1286170012090 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1286170012091 putative dimerization interface [polypeptide binding]; other site 1286170012092 threonine dehydratase; Reviewed; Region: PRK09224 1286170012093 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1286170012094 tetramer interface [polypeptide binding]; other site 1286170012095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170012096 catalytic residue [active] 1286170012097 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1286170012098 putative Ile/Val binding site [chemical binding]; other site 1286170012099 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1286170012100 putative Ile/Val binding site [chemical binding]; other site 1286170012101 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1286170012102 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1286170012103 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1286170012104 homodimer interface [polypeptide binding]; other site 1286170012105 substrate-cofactor binding pocket; other site 1286170012106 catalytic residue [active] 1286170012107 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1286170012108 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1286170012109 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286170012110 PYR/PP interface [polypeptide binding]; other site 1286170012111 dimer interface [polypeptide binding]; other site 1286170012112 TPP binding site [chemical binding]; other site 1286170012113 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286170012114 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1286170012115 TPP-binding site [chemical binding]; other site 1286170012116 dimer interface [polypeptide binding]; other site 1286170012117 putative ATP-dependent protease; Provisional; Region: PRK09862 1286170012118 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1286170012119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170012120 Walker A motif; other site 1286170012121 ATP binding site [chemical binding]; other site 1286170012122 Walker B motif; other site 1286170012123 arginine finger; other site 1286170012124 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1286170012125 hypothetical protein; Provisional; Region: PRK11027 1286170012126 transcriptional regulator HdfR; Provisional; Region: PRK03601 1286170012127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170012128 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1286170012129 glutamate racemase; Provisional; Region: PRK00865 1286170012130 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1286170012131 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170012132 N-terminal plug; other site 1286170012133 ligand-binding site [chemical binding]; other site 1286170012134 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1286170012135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170012136 S-adenosylmethionine binding site [chemical binding]; other site 1286170012137 hypothetical protein; Provisional; Region: PRK11056 1286170012138 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1286170012139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170012140 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1286170012141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170012142 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286170012143 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1286170012144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170012145 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1286170012146 dimerization interface [polypeptide binding]; other site 1286170012147 argininosuccinate lyase; Provisional; Region: PRK04833 1286170012148 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1286170012149 active sites [active] 1286170012150 tetramer interface [polypeptide binding]; other site 1286170012151 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1286170012152 nucleotide binding site [chemical binding]; other site 1286170012153 N-acetyl-L-glutamate binding site [chemical binding]; other site 1286170012154 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1286170012155 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1286170012156 acetylornithine deacetylase; Provisional; Region: PRK05111 1286170012157 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1286170012158 metal binding site [ion binding]; metal-binding site 1286170012159 putative dimer interface [polypeptide binding]; other site 1286170012160 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1286170012161 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1286170012162 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1286170012163 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170012164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170012165 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1286170012166 active site 1286170012167 intersubunit interactions; other site 1286170012168 catalytic residue [active] 1286170012169 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1286170012170 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1286170012171 dimer interface [polypeptide binding]; other site 1286170012172 active site 1286170012173 metal binding site [ion binding]; metal-binding site 1286170012174 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1286170012175 FAD binding site [chemical binding]; other site 1286170012176 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170012177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170012178 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1286170012179 dimerization interface [polypeptide binding]; other site 1286170012180 substrate binding pocket [chemical binding]; other site 1286170012181 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1286170012182 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1286170012183 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1286170012184 putative catalytic residues [active] 1286170012185 putative nucleotide binding site [chemical binding]; other site 1286170012186 putative aspartate binding site [chemical binding]; other site 1286170012187 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1286170012188 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1286170012189 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1286170012190 cystathionine gamma-synthase; Provisional; Region: PRK08045 1286170012191 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286170012192 homodimer interface [polypeptide binding]; other site 1286170012193 substrate-cofactor binding pocket; other site 1286170012194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170012195 catalytic residue [active] 1286170012196 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1286170012197 dimerization interface [polypeptide binding]; other site 1286170012198 DNA binding site [nucleotide binding] 1286170012199 corepressor binding sites; other site 1286170012200 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1286170012201 primosome assembly protein PriA; Validated; Region: PRK05580 1286170012202 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286170012203 ATP binding site [chemical binding]; other site 1286170012204 putative Mg++ binding site [ion binding]; other site 1286170012205 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1286170012206 ATP-binding site [chemical binding]; other site 1286170012207 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170012208 DNA binding site [nucleotide binding] 1286170012209 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1286170012210 domain linker motif; other site 1286170012211 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1286170012212 dimerization interface [polypeptide binding]; other site 1286170012213 ligand binding site [chemical binding]; other site 1286170012214 essential cell division protein FtsN; Provisional; Region: PRK10927 1286170012215 cell division protein FtsN; Provisional; Region: PRK12757 1286170012216 Sporulation related domain; Region: SPOR; cl10051 1286170012217 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1286170012218 active site 1286170012219 HslU subunit interaction site [polypeptide binding]; other site 1286170012220 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1286170012221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170012222 Walker A motif; other site 1286170012223 ATP binding site [chemical binding]; other site 1286170012224 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1286170012225 Walker B motif; other site 1286170012226 arginine finger; other site 1286170012227 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1286170012228 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1286170012229 UbiA prenyltransferase family; Region: UbiA; pfam01040 1286170012230 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1286170012231 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1286170012232 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1286170012233 active site 1286170012234 ADP/pyrophosphate binding site [chemical binding]; other site 1286170012235 dimerization interface [polypeptide binding]; other site 1286170012236 allosteric effector site; other site 1286170012237 fructose-1,6-bisphosphate binding site; other site 1286170012238 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1286170012239 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1286170012240 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1286170012241 dimer interface [polypeptide binding]; other site 1286170012242 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1286170012243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170012244 active site 1286170012245 intermolecular recognition site; other site 1286170012246 dimerization interface [polypeptide binding]; other site 1286170012247 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170012248 DNA binding site [nucleotide binding] 1286170012249 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1286170012250 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286170012251 dimerization interface [polypeptide binding]; other site 1286170012252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170012253 dimer interface [polypeptide binding]; other site 1286170012254 phosphorylation site [posttranslational modification] 1286170012255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170012256 ATP binding site [chemical binding]; other site 1286170012257 Mg2+ binding site [ion binding]; other site 1286170012258 G-X-G motif; other site 1286170012259 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1286170012260 MOSC domain; Region: MOSC; pfam03473 1286170012261 3-alpha domain; Region: 3-alpha; pfam03475 1286170012262 superoxide dismutase; Provisional; Region: PRK10925 1286170012263 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1286170012264 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1286170012265 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1286170012266 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1286170012267 transcriptional activator RhaR; Provisional; Region: PRK13502 1286170012268 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286170012269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170012270 transcriptional activator RhaS; Provisional; Region: PRK13503 1286170012271 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286170012272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170012273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170012274 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1286170012275 N- and C-terminal domain interface [polypeptide binding]; other site 1286170012276 active site 1286170012277 putative catalytic site [active] 1286170012278 metal binding site [ion binding]; metal-binding site 1286170012279 ATP binding site [chemical binding]; other site 1286170012280 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1286170012281 carbohydrate binding site [chemical binding]; other site 1286170012282 L-rhamnose isomerase; Provisional; Region: PRK01076 1286170012283 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1286170012284 intersubunit interface [polypeptide binding]; other site 1286170012285 active site 1286170012286 Zn2+ binding site [ion binding]; other site 1286170012287 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1286170012288 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 1286170012289 ligand binding site [chemical binding]; other site 1286170012290 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286170012291 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170012292 Walker A/P-loop; other site 1286170012293 ATP binding site [chemical binding]; other site 1286170012294 Q-loop/lid; other site 1286170012295 ABC transporter signature motif; other site 1286170012296 Walker B; other site 1286170012297 D-loop; other site 1286170012298 H-loop/switch region; other site 1286170012299 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170012300 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170012301 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170012302 TM-ABC transporter signature motif; other site 1286170012303 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170012304 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170012305 TM-ABC transporter signature motif; other site 1286170012306 lactaldehyde reductase; Region: lactal_redase; TIGR02638 1286170012307 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1286170012308 dimer interface [polypeptide binding]; other site 1286170012309 active site 1286170012310 metal binding site [ion binding]; metal-binding site 1286170012311 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1286170012312 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1286170012313 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1286170012314 putative symporter YagG; Provisional; Region: PRK09669 1286170012315 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170012316 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1286170012317 dimerization interface [polypeptide binding]; other site 1286170012318 ligand binding site [chemical binding]; other site 1286170012319 galactoside permease; Reviewed; Region: lacY; PRK09528 1286170012320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012321 putative substrate translocation pore; other site 1286170012322 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1286170012323 Melibiase; Region: Melibiase; pfam02065 1286170012324 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170012325 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170012326 DNA binding site [nucleotide binding] 1286170012327 domain linker motif; other site 1286170012328 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1286170012329 ligand binding site [chemical binding]; other site 1286170012330 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286170012331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170012332 non-specific DNA binding site [nucleotide binding]; other site 1286170012333 salt bridge; other site 1286170012334 sequence-specific DNA binding site [nucleotide binding]; other site 1286170012335 Cupin domain; Region: Cupin_2; cl17218 1286170012336 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1286170012337 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1286170012338 AAA domain; Region: AAA_17; pfam13207 1286170012339 AAA domain; Region: AAA_18; pfam13238 1286170012340 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286170012341 active site 1286170012342 phosphorylation site [posttranslational modification] 1286170012343 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1286170012344 intersubunit interface [polypeptide binding]; other site 1286170012345 active site 1286170012346 zinc binding site [ion binding]; other site 1286170012347 Na+ binding site [ion binding]; other site 1286170012348 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1286170012349 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1286170012350 active site 1286170012351 P-loop; other site 1286170012352 phosphorylation site [posttranslational modification] 1286170012353 dimerization interface [polypeptide binding]; other site 1286170012354 allosteric effector site; other site 1286170012355 active site 1286170012356 ADP/pyrophosphate binding site [chemical binding]; other site 1286170012357 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1286170012358 fructose-1,6-bisphosphate binding site; other site 1286170012359 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1286170012360 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170012361 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286170012362 molybdopterin cofactor binding site; other site 1286170012363 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1286170012364 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1286170012365 molybdopterin cofactor binding site; other site 1286170012366 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1286170012367 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1286170012368 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1286170012369 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1286170012370 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1286170012371 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1286170012372 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1286170012373 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1286170012374 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1286170012375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170012376 Coenzyme A binding pocket [chemical binding]; other site 1286170012377 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1286170012378 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1286170012379 putative active site [active] 1286170012380 dimerization interface [polypeptide binding]; other site 1286170012381 putative tRNAtyr binding site [nucleotide binding]; other site 1286170012382 hypothetical protein; Reviewed; Region: PRK01637 1286170012383 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1286170012384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170012385 motif II; other site 1286170012386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012387 putative substrate translocation pore; other site 1286170012388 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1286170012389 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1286170012390 transcriptional regulator protein; Region: phnR; TIGR03337 1286170012391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170012392 DNA-binding site [nucleotide binding]; DNA binding site 1286170012393 UTRA domain; Region: UTRA; pfam07702 1286170012394 GTP-binding protein; Provisional; Region: PRK10218 1286170012395 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1286170012396 G1 box; other site 1286170012397 putative GEF interaction site [polypeptide binding]; other site 1286170012398 GTP/Mg2+ binding site [chemical binding]; other site 1286170012399 Switch I region; other site 1286170012400 G2 box; other site 1286170012401 G3 box; other site 1286170012402 Switch II region; other site 1286170012403 G4 box; other site 1286170012404 G5 box; other site 1286170012405 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1286170012406 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1286170012407 glutamine synthetase; Provisional; Region: glnA; PRK09469 1286170012408 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1286170012409 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1286170012410 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1286170012411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1286170012412 putative active site [active] 1286170012413 heme pocket [chemical binding]; other site 1286170012414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170012415 dimer interface [polypeptide binding]; other site 1286170012416 phosphorylation site [posttranslational modification] 1286170012417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170012418 ATP binding site [chemical binding]; other site 1286170012419 Mg2+ binding site [ion binding]; other site 1286170012420 G-X-G motif; other site 1286170012421 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1286170012422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170012423 active site 1286170012424 phosphorylation site [posttranslational modification] 1286170012425 intermolecular recognition site; other site 1286170012426 dimerization interface [polypeptide binding]; other site 1286170012427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170012428 Walker A motif; other site 1286170012429 ATP binding site [chemical binding]; other site 1286170012430 Walker B motif; other site 1286170012431 arginine finger; other site 1286170012432 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286170012433 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1286170012434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170012435 FeS/SAM binding site; other site 1286170012436 HemN C-terminal domain; Region: HemN_C; pfam06969 1286170012437 Der GTPase activator; Provisional; Region: PRK05244 1286170012438 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1286170012439 G1 box; other site 1286170012440 GTP/Mg2+ binding site [chemical binding]; other site 1286170012441 Switch I region; other site 1286170012442 G2 box; other site 1286170012443 G3 box; other site 1286170012444 Switch II region; other site 1286170012445 G4 box; other site 1286170012446 G5 box; other site 1286170012447 DNA polymerase I; Provisional; Region: PRK05755 1286170012448 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1286170012449 active site 1286170012450 metal binding site 1 [ion binding]; metal-binding site 1286170012451 putative 5' ssDNA interaction site; other site 1286170012452 metal binding site 3; metal-binding site 1286170012453 metal binding site 2 [ion binding]; metal-binding site 1286170012454 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1286170012455 putative DNA binding site [nucleotide binding]; other site 1286170012456 putative metal binding site [ion binding]; other site 1286170012457 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1286170012458 active site 1286170012459 catalytic site [active] 1286170012460 substrate binding site [chemical binding]; other site 1286170012461 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1286170012462 active site 1286170012463 DNA binding site [nucleotide binding] 1286170012464 catalytic site [active] 1286170012465 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1286170012466 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1286170012467 putative acyl-acceptor binding pocket; other site 1286170012468 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1286170012469 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1286170012470 catalytic residues [active] 1286170012471 hinge region; other site 1286170012472 alpha helical domain; other site 1286170012473 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1286170012474 serine/threonine protein kinase; Provisional; Region: PRK11768 1286170012475 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1286170012476 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1286170012477 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1286170012478 GTP binding site; other site 1286170012479 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1286170012480 Walker A motif; other site 1286170012481 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286170012482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170012483 DNA-binding site [nucleotide binding]; DNA binding site 1286170012484 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286170012485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012487 transcriptional repressor RbsR; Provisional; Region: PRK10423 1286170012488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170012489 DNA binding site [nucleotide binding] 1286170012490 domain linker motif; other site 1286170012491 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1286170012492 dimerization interface [polypeptide binding]; other site 1286170012493 ligand binding site [chemical binding]; other site 1286170012494 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170012495 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1286170012496 substrate binding site [chemical binding]; other site 1286170012497 dimer interface [polypeptide binding]; other site 1286170012498 ATP binding site [chemical binding]; other site 1286170012499 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1286170012500 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1286170012501 ligand binding site [chemical binding]; other site 1286170012502 dimerization interface [polypeptide binding]; other site 1286170012503 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170012504 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170012505 TM-ABC transporter signature motif; other site 1286170012506 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1286170012507 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170012508 Walker A/P-loop; other site 1286170012509 ATP binding site [chemical binding]; other site 1286170012510 Q-loop/lid; other site 1286170012511 ABC transporter signature motif; other site 1286170012512 Walker B; other site 1286170012513 D-loop; other site 1286170012514 H-loop/switch region; other site 1286170012515 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170012516 D-ribose pyranase; Provisional; Region: PRK11797 1286170012517 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1286170012518 potassium uptake protein; Region: kup; TIGR00794 1286170012519 regulatory ATPase RavA; Provisional; Region: PRK13531 1286170012520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170012521 Walker A motif; other site 1286170012522 ATP binding site [chemical binding]; other site 1286170012523 Walker B motif; other site 1286170012524 arginine finger; other site 1286170012525 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1286170012526 hypothetical protein; Provisional; Region: yieM; PRK10997 1286170012527 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1286170012528 metal ion-dependent adhesion site (MIDAS); other site 1286170012529 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1286170012530 dimer interface [polypeptide binding]; other site 1286170012531 active site 1286170012532 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1286170012533 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286170012534 putative DNA binding site [nucleotide binding]; other site 1286170012535 putative Zn2+ binding site [ion binding]; other site 1286170012536 AsnC family; Region: AsnC_trans_reg; pfam01037 1286170012537 FMN-binding protein MioC; Provisional; Region: PRK09004 1286170012538 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1286170012539 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1286170012540 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1286170012541 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1286170012542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170012543 S-adenosylmethionine binding site [chemical binding]; other site 1286170012544 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1286170012545 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1286170012546 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1286170012547 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1286170012548 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1286170012549 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1286170012550 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1286170012551 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1286170012552 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1286170012553 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1286170012554 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1286170012555 beta subunit interaction interface [polypeptide binding]; other site 1286170012556 Walker A motif; other site 1286170012557 ATP binding site [chemical binding]; other site 1286170012558 Walker B motif; other site 1286170012559 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1286170012560 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1286170012561 core domain interface [polypeptide binding]; other site 1286170012562 delta subunit interface [polypeptide binding]; other site 1286170012563 epsilon subunit interface [polypeptide binding]; other site 1286170012564 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1286170012565 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1286170012566 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1286170012567 alpha subunit interaction interface [polypeptide binding]; other site 1286170012568 Walker A motif; other site 1286170012569 ATP binding site [chemical binding]; other site 1286170012570 Walker B motif; other site 1286170012571 inhibitor binding site; inhibition site 1286170012572 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1286170012573 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1286170012574 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1286170012575 gamma subunit interface [polypeptide binding]; other site 1286170012576 epsilon subunit interface [polypeptide binding]; other site 1286170012577 LBP interface [polypeptide binding]; other site 1286170012578 Right handed beta helix region; Region: Beta_helix; pfam13229 1286170012579 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1286170012580 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1286170012581 Substrate binding site; other site 1286170012582 Mg++ binding site; other site 1286170012583 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1286170012584 active site 1286170012585 substrate binding site [chemical binding]; other site 1286170012586 CoA binding site [chemical binding]; other site 1286170012587 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1286170012588 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1286170012589 glutaminase active site [active] 1286170012590 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1286170012591 dimer interface [polypeptide binding]; other site 1286170012592 active site 1286170012593 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1286170012594 dimer interface [polypeptide binding]; other site 1286170012595 active site 1286170012596 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170012597 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1286170012598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170012599 dimer interface [polypeptide binding]; other site 1286170012600 conserved gate region; other site 1286170012601 putative PBP binding loops; other site 1286170012602 ABC-ATPase subunit interface; other site 1286170012603 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1286170012604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170012605 dimer interface [polypeptide binding]; other site 1286170012606 conserved gate region; other site 1286170012607 putative PBP binding loops; other site 1286170012608 ABC-ATPase subunit interface; other site 1286170012609 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1286170012610 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1286170012611 Walker A/P-loop; other site 1286170012612 ATP binding site [chemical binding]; other site 1286170012613 Q-loop/lid; other site 1286170012614 ABC transporter signature motif; other site 1286170012615 Walker B; other site 1286170012616 D-loop; other site 1286170012617 H-loop/switch region; other site 1286170012618 transcriptional regulator PhoU; Provisional; Region: PRK11115 1286170012619 PhoU domain; Region: PhoU; pfam01895 1286170012620 PhoU domain; Region: PhoU; pfam01895 1286170012621 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1286170012622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170012623 motif II; other site 1286170012624 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1286170012625 Predicted flavoprotein [General function prediction only]; Region: COG0431 1286170012626 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286170012627 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1286170012628 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1286170012629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170012630 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1286170012631 substrate binding pocket [chemical binding]; other site 1286170012632 dimerization interface [polypeptide binding]; other site 1286170012633 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1286170012634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012635 putative substrate translocation pore; other site 1286170012636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170012637 Coenzyme A binding pocket [chemical binding]; other site 1286170012638 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1286170012639 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1286170012640 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1286170012641 G1 box; other site 1286170012642 GTP/Mg2+ binding site [chemical binding]; other site 1286170012643 Switch I region; other site 1286170012644 G2 box; other site 1286170012645 Switch II region; other site 1286170012646 G3 box; other site 1286170012647 G4 box; other site 1286170012648 G5 box; other site 1286170012649 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1286170012650 membrane protein insertase; Provisional; Region: PRK01318 1286170012651 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1286170012652 hypothetical protein; Validated; Region: PRK00041 1286170012653 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1286170012654 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1286170012655 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1286170012656 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1286170012657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170012658 Walker A motif; other site 1286170012659 ATP binding site [chemical binding]; other site 1286170012660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1286170012661 Walker B motif; other site 1286170012662 arginine finger; other site 1286170012663 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1286170012664 DnaA box-binding interface [nucleotide binding]; other site 1286170012665 DNA polymerase III subunit beta; Validated; Region: PRK05643 1286170012666 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1286170012667 putative DNA binding surface [nucleotide binding]; other site 1286170012668 dimer interface [polypeptide binding]; other site 1286170012669 beta-clamp/clamp loader binding surface; other site 1286170012670 beta-clamp/translesion DNA polymerase binding surface; other site 1286170012671 recF protein; Region: recf; TIGR00611 1286170012672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170012673 Walker A/P-loop; other site 1286170012674 ATP binding site [chemical binding]; other site 1286170012675 Q-loop/lid; other site 1286170012676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170012677 ABC transporter signature motif; other site 1286170012678 Walker B; other site 1286170012679 D-loop; other site 1286170012680 H-loop/switch region; other site 1286170012681 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1286170012682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170012683 Mg2+ binding site [ion binding]; other site 1286170012684 G-X-G motif; other site 1286170012685 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1286170012686 anchoring element; other site 1286170012687 dimer interface [polypeptide binding]; other site 1286170012688 ATP binding site [chemical binding]; other site 1286170012689 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1286170012690 active site 1286170012691 putative metal-binding site [ion binding]; other site 1286170012692 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1286170012693 sugar phosphate phosphatase; Provisional; Region: PRK10513 1286170012694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170012695 active site 1286170012696 motif I; other site 1286170012697 motif II; other site 1286170012698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170012699 Surface antigen; Region: Bac_surface_Ag; pfam01103 1286170012700 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170012701 DNA-binding site [nucleotide binding]; DNA binding site 1286170012702 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286170012703 FCD domain; Region: FCD; pfam07729 1286170012704 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1286170012705 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1286170012706 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1286170012707 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1286170012708 active site 1286170012709 intersubunit interface [polypeptide binding]; other site 1286170012710 catalytic residue [active] 1286170012711 galactonate dehydratase; Provisional; Region: PRK14017 1286170012712 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1286170012713 putative active site pocket [active] 1286170012714 putative metal binding site [ion binding]; other site 1286170012715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012716 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170012717 putative substrate translocation pore; other site 1286170012718 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1286170012719 hypothetical protein; Provisional; Region: PRK11616 1286170012720 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1286170012721 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1286170012722 putative dimer interface [polypeptide binding]; other site 1286170012723 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1286170012724 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1286170012725 putative dimer interface [polypeptide binding]; other site 1286170012726 putative transporter; Validated; Region: PRK03818 1286170012727 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1286170012728 TrkA-C domain; Region: TrkA_C; pfam02080 1286170012729 TrkA-C domain; Region: TrkA_C; pfam02080 1286170012730 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1286170012731 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286170012732 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170012733 DNA-binding site [nucleotide binding]; DNA binding site 1286170012734 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1286170012735 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1286170012736 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1286170012737 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170012738 active site turn [active] 1286170012739 phosphorylation site [posttranslational modification] 1286170012740 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1286170012741 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1286170012742 NAD binding site [chemical binding]; other site 1286170012743 sugar binding site [chemical binding]; other site 1286170012744 divalent metal binding site [ion binding]; other site 1286170012745 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286170012746 dimer interface [polypeptide binding]; other site 1286170012747 Predicted membrane protein [Function unknown]; Region: COG2149 1286170012748 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1286170012749 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1286170012750 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1286170012751 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286170012752 catalytic residue [active] 1286170012753 permease DsdX; Provisional; Region: PRK09921 1286170012754 gluconate transporter; Region: gntP; TIGR00791 1286170012755 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1286170012756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170012757 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1286170012758 dimerization interface [polypeptide binding]; other site 1286170012759 substrate binding pocket [chemical binding]; other site 1286170012760 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1286170012761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012762 putative substrate translocation pore; other site 1286170012763 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1286170012764 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286170012765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170012766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286170012767 Coenzyme A binding pocket [chemical binding]; other site 1286170012768 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1286170012769 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286170012770 PYR/PP interface [polypeptide binding]; other site 1286170012771 dimer interface [polypeptide binding]; other site 1286170012772 TPP binding site [chemical binding]; other site 1286170012773 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286170012774 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1286170012775 TPP-binding site [chemical binding]; other site 1286170012776 dimer interface [polypeptide binding]; other site 1286170012777 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1286170012778 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1286170012779 putative valine binding site [chemical binding]; other site 1286170012780 dimer interface [polypeptide binding]; other site 1286170012781 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1286170012782 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1286170012783 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286170012784 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170012785 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1286170012786 substrate binding site [chemical binding]; other site 1286170012787 dimer interface [polypeptide binding]; other site 1286170012788 ATP binding site [chemical binding]; other site 1286170012789 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1286170012790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012791 putative substrate translocation pore; other site 1286170012792 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1286170012793 active site 1286170012794 catalytic residues [active] 1286170012795 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1286170012796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170012797 active site 1286170012798 phosphorylation site [posttranslational modification] 1286170012799 intermolecular recognition site; other site 1286170012800 dimerization interface [polypeptide binding]; other site 1286170012801 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170012802 DNA binding residues [nucleotide binding] 1286170012803 dimerization interface [polypeptide binding]; other site 1286170012804 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1286170012805 MASE1; Region: MASE1; pfam05231 1286170012806 Histidine kinase; Region: HisKA_3; pfam07730 1286170012807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170012808 ATP binding site [chemical binding]; other site 1286170012809 Mg2+ binding site [ion binding]; other site 1286170012810 G-X-G motif; other site 1286170012811 regulatory protein UhpC; Provisional; Region: PRK11663 1286170012812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012813 putative substrate translocation pore; other site 1286170012814 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1286170012815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012816 putative substrate translocation pore; other site 1286170012817 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1286170012818 motif 2; other site 1286170012819 active site 1286170012820 motif 3; other site 1286170012821 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1286170012822 anticodon binding site; other site 1286170012823 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1286170012824 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1286170012825 dimer interface [polypeptide binding]; other site 1286170012826 motif 1; other site 1286170012827 active site 1286170012828 motif 2; other site 1286170012829 motif 3; other site 1286170012830 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1286170012831 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 1286170012832 histidine decarboxylase; Provisional; Region: PRK02769 1286170012833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286170012834 catalytic residue [active] 1286170012835 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 1286170012836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170012837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170012838 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170012839 dimerization interface [polypeptide binding]; other site 1286170012840 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1286170012841 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1286170012842 putative hydrophobic ligand binding site [chemical binding]; other site 1286170012843 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1286170012844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012845 putative substrate translocation pore; other site 1286170012846 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1286170012847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170012848 motif II; other site 1286170012849 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1286170012850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286170012851 catalytic residue [active] 1286170012852 transcriptional regulator protein; Region: phnR; TIGR03337 1286170012853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170012854 DNA-binding site [nucleotide binding]; DNA binding site 1286170012855 UTRA domain; Region: UTRA; pfam07702 1286170012856 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1286170012857 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286170012858 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 1286170012859 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170012860 Walker A/P-loop; other site 1286170012861 ATP binding site [chemical binding]; other site 1286170012862 Q-loop/lid; other site 1286170012863 ABC transporter signature motif; other site 1286170012864 Walker B; other site 1286170012865 D-loop; other site 1286170012866 H-loop/switch region; other site 1286170012867 TOBE domain; Region: TOBE_2; pfam08402 1286170012868 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1286170012869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170012870 dimer interface [polypeptide binding]; other site 1286170012871 conserved gate region; other site 1286170012872 putative PBP binding loops; other site 1286170012873 ABC-ATPase subunit interface; other site 1286170012874 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286170012875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170012876 dimer interface [polypeptide binding]; other site 1286170012877 conserved gate region; other site 1286170012878 putative PBP binding loops; other site 1286170012879 ABC-ATPase subunit interface; other site 1286170012880 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1286170012881 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1286170012882 methionine cluster; other site 1286170012883 active site 1286170012884 phosphorylation site [posttranslational modification] 1286170012885 metal binding site [ion binding]; metal-binding site 1286170012886 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1286170012887 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1286170012888 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1286170012889 active site 1286170012890 P-loop; other site 1286170012891 phosphorylation site [posttranslational modification] 1286170012892 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170012893 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170012894 DNA binding site [nucleotide binding] 1286170012895 domain linker motif; other site 1286170012896 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1286170012897 ligand binding site [chemical binding]; other site 1286170012898 benzoate transport; Region: 2A0115; TIGR00895 1286170012899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012900 putative substrate translocation pore; other site 1286170012901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012902 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 1286170012903 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 1286170012904 putative active site [active] 1286170012905 Fe(II) binding site [ion binding]; other site 1286170012906 putative dimer interface [polypeptide binding]; other site 1286170012907 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 1286170012908 putative dimer interface [polypeptide binding]; other site 1286170012909 putative N- and C-terminal domain interface [polypeptide binding]; other site 1286170012910 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170012911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170012912 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1286170012913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170012914 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1286170012915 putative dimerization interface [polypeptide binding]; other site 1286170012916 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1286170012917 hypothetical protein; Provisional; Region: PRK09262 1286170012918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1286170012919 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1286170012920 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1286170012921 EamA-like transporter family; Region: EamA; pfam00892 1286170012922 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286170012923 CcdB protein; Region: CcdB; cl03380 1286170012924 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1286170012925 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1286170012926 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170012927 active site turn [active] 1286170012928 phosphorylation site [posttranslational modification] 1286170012929 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286170012930 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1286170012931 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1286170012932 putative active site [active] 1286170012933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012934 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170012935 putative substrate translocation pore; other site 1286170012936 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1286170012937 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1286170012938 Protein export membrane protein; Region: SecD_SecF; cl14618 1286170012939 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1286170012940 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170012941 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170012942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286170012943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170012944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170012945 Coenzyme A binding pocket [chemical binding]; other site 1286170012946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286170012947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170012948 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1286170012949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012950 putative substrate translocation pore; other site 1286170012951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170012952 transcriptional regulator; Provisional; Region: PRK10632 1286170012953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170012954 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1286170012955 putative effector binding pocket; other site 1286170012956 putative dimerization interface [polypeptide binding]; other site 1286170012957 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1286170012958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1286170012959 SnoaL-like domain; Region: SnoaL_2; pfam12680 1286170012960 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1286170012961 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1286170012962 Cupin; Region: Cupin_6; pfam12852 1286170012963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170012964 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170012965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170012966 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1286170012967 lipoprotein, YaeC family; Region: TIGR00363 1286170012968 EamA-like transporter family; Region: EamA; pfam00892 1286170012969 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1286170012970 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1286170012971 dimer interface [polypeptide binding]; other site 1286170012972 ADP-ribose binding site [chemical binding]; other site 1286170012973 active site 1286170012974 nudix motif; other site 1286170012975 metal binding site [ion binding]; metal-binding site 1286170012976 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1286170012977 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1286170012978 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1286170012979 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1286170012980 conserved cys residue [active] 1286170012981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170012982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170012983 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1286170012984 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1286170012985 putative NAD(P) binding site [chemical binding]; other site 1286170012986 putative substrate binding site [chemical binding]; other site 1286170012987 catalytic Zn binding site [ion binding]; other site 1286170012988 structural Zn binding site [ion binding]; other site 1286170012989 dimer interface [polypeptide binding]; other site 1286170012990 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1286170012991 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1286170012992 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1286170012993 putative NAD(P) binding site [chemical binding]; other site 1286170012994 dimer interface [polypeptide binding]; other site 1286170012995 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1286170012996 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286170012997 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170012998 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170012999 putative active site [active] 1286170013000 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1286170013001 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1286170013002 NAD(P) binding site [chemical binding]; other site 1286170013003 LDH/MDH dimer interface [polypeptide binding]; other site 1286170013004 substrate binding site [chemical binding]; other site 1286170013005 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286170013006 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1286170013007 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170013008 active site turn [active] 1286170013009 phosphorylation site [posttranslational modification] 1286170013010 AsmA family; Region: AsmA; pfam05170 1286170013011 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1286170013012 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1286170013013 glycerol kinase; Provisional; Region: glpK; PRK00047 1286170013014 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1286170013015 N- and C-terminal domain interface [polypeptide binding]; other site 1286170013016 active site 1286170013017 MgATP binding site [chemical binding]; other site 1286170013018 catalytic site [active] 1286170013019 metal binding site [ion binding]; metal-binding site 1286170013020 glycerol binding site [chemical binding]; other site 1286170013021 homotetramer interface [polypeptide binding]; other site 1286170013022 homodimer interface [polypeptide binding]; other site 1286170013023 FBP binding site [chemical binding]; other site 1286170013024 protein IIAGlc interface [polypeptide binding]; other site 1286170013025 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1286170013026 amphipathic channel; other site 1286170013027 Asn-Pro-Ala signature motifs; other site 1286170013028 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1286170013029 sulfate transporter subunit; Provisional; Region: PRK10752 1286170013030 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286170013031 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 1286170013032 transmembrane helices; other site 1286170013033 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1286170013034 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1286170013035 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1286170013036 triosephosphate isomerase; Provisional; Region: PRK14567 1286170013037 substrate binding site [chemical binding]; other site 1286170013038 dimer interface [polypeptide binding]; other site 1286170013039 catalytic triad [active] 1286170013040 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1286170013041 Predicted membrane protein [Function unknown]; Region: COG3152 1286170013042 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1286170013043 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1286170013044 FAD binding pocket [chemical binding]; other site 1286170013045 FAD binding motif [chemical binding]; other site 1286170013046 phosphate binding motif [ion binding]; other site 1286170013047 beta-alpha-beta structure motif; other site 1286170013048 NAD binding pocket [chemical binding]; other site 1286170013049 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1286170013050 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1286170013051 putative active site [active] 1286170013052 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1286170013053 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1286170013054 generic binding surface II; other site 1286170013055 ssDNA binding site; other site 1286170013056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286170013057 ATP binding site [chemical binding]; other site 1286170013058 putative Mg++ binding site [ion binding]; other site 1286170013059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170013060 nucleotide binding region [chemical binding]; other site 1286170013061 ATP-binding site [chemical binding]; other site 1286170013062 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1286170013063 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1286170013064 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1286170013065 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1286170013066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286170013067 Zn2+ binding site [ion binding]; other site 1286170013068 Mg2+ binding site [ion binding]; other site 1286170013069 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1286170013070 synthetase active site [active] 1286170013071 NTP binding site [chemical binding]; other site 1286170013072 metal binding site [ion binding]; metal-binding site 1286170013073 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1286170013074 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1286170013075 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1286170013076 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1286170013077 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1286170013078 catalytic site [active] 1286170013079 G-X2-G-X-G-K; other site 1286170013080 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1286170013081 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1286170013082 nucleotide binding pocket [chemical binding]; other site 1286170013083 K-X-D-G motif; other site 1286170013084 catalytic site [active] 1286170013085 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1286170013086 Predicted membrane protein [Function unknown]; Region: COG2860 1286170013087 UPF0126 domain; Region: UPF0126; pfam03458 1286170013088 UPF0126 domain; Region: UPF0126; pfam03458 1286170013089 hypothetical protein; Provisional; Region: PRK11820 1286170013090 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1286170013091 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1286170013092 ribonuclease PH; Reviewed; Region: rph; PRK00173 1286170013093 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1286170013094 hexamer interface [polypeptide binding]; other site 1286170013095 active site 1286170013096 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286170013097 active site 1286170013098 division inhibitor protein; Provisional; Region: slmA; PRK09480 1286170013099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286170013100 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1286170013101 trimer interface [polypeptide binding]; other site 1286170013102 active site 1286170013103 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1286170013104 Flavoprotein; Region: Flavoprotein; pfam02441 1286170013105 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1286170013106 hypothetical protein; Reviewed; Region: PRK00024 1286170013107 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1286170013108 MPN+ (JAMM) motif; other site 1286170013109 Zinc-binding site [ion binding]; other site 1286170013110 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1286170013111 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1286170013112 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1286170013113 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1286170013114 DNA binding site [nucleotide binding] 1286170013115 catalytic residue [active] 1286170013116 H2TH interface [polypeptide binding]; other site 1286170013117 putative catalytic residues [active] 1286170013118 turnover-facilitating residue; other site 1286170013119 intercalation triad [nucleotide binding]; other site 1286170013120 8OG recognition residue [nucleotide binding]; other site 1286170013121 putative reading head residues; other site 1286170013122 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1286170013123 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1286170013124 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1286170013125 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1286170013126 active site 1286170013127 (T/H)XGH motif; other site 1286170013128 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286170013129 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1286170013130 putative metal binding site; other site 1286170013131 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1286170013132 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1286170013133 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1286170013134 putative glycosyl transferase; Provisional; Region: PRK10073 1286170013135 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286170013136 active site 1286170013137 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286170013138 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1286170013139 putative ADP-binding pocket [chemical binding]; other site 1286170013140 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286170013141 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286170013142 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1286170013143 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1286170013144 putative active site [active] 1286170013145 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 1286170013146 putative active site [active] 1286170013147 putative catalytic site [active] 1286170013148 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1286170013149 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1286170013150 O-Antigen ligase; Region: Wzy_C; pfam04932 1286170013151 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1286170013152 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1286170013153 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1286170013154 putative active site [active] 1286170013155 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1286170013156 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1286170013157 putative active site [active] 1286170013158 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1286170013159 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1286170013160 NADP binding site [chemical binding]; other site 1286170013161 homopentamer interface [polypeptide binding]; other site 1286170013162 substrate binding site [chemical binding]; other site 1286170013163 active site 1286170013164 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1286170013165 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1286170013166 substrate-cofactor binding pocket; other site 1286170013167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170013168 catalytic residue [active] 1286170013169 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1286170013170 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286170013171 NAD(P) binding site [chemical binding]; other site 1286170013172 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286170013173 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1286170013174 putative metal binding site; other site 1286170013175 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1286170013176 NodB motif; other site 1286170013177 putative active site [active] 1286170013178 putative catalytic site [active] 1286170013179 Zn binding site [ion binding]; other site 1286170013180 AmiB activator; Provisional; Region: PRK11637 1286170013181 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286170013182 phosphoglyceromutase; Provisional; Region: PRK05434 1286170013183 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1286170013184 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1286170013185 active site residue [active] 1286170013186 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1286170013187 GSH binding site [chemical binding]; other site 1286170013188 catalytic residues [active] 1286170013189 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1286170013190 SecA binding site; other site 1286170013191 Preprotein binding site; other site 1286170013192 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1286170013193 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1286170013194 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1286170013195 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1286170013196 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1286170013197 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1286170013198 trimer interface [polypeptide binding]; other site 1286170013199 active site 1286170013200 substrate binding site [chemical binding]; other site 1286170013201 CoA binding site [chemical binding]; other site 1286170013202 putative rRNA methylase; Provisional; Region: PRK10358 1286170013203 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1286170013204 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1286170013205 active site 1286170013206 substrate binding site [chemical binding]; other site 1286170013207 FMN binding site [chemical binding]; other site 1286170013208 putative catalytic residues [active] 1286170013209 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1286170013210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170013211 DNA-binding site [nucleotide binding]; DNA binding site 1286170013212 FCD domain; Region: FCD; pfam07729 1286170013213 L-lactate permease; Provisional; Region: PRK10420 1286170013214 glycolate transporter; Provisional; Region: PRK09695 1286170013215 hypothetical protein; Provisional; Region: PRK11020 1286170013216 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1286170013217 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1286170013218 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1286170013219 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1286170013220 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1286170013221 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1286170013222 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1286170013223 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1286170013224 active site 1286170013225 P-loop; other site 1286170013226 phosphorylation site [posttranslational modification] 1286170013227 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286170013228 active site 1286170013229 phosphorylation site [posttranslational modification] 1286170013230 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1286170013231 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1286170013232 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170013233 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170013234 putative glutathione S-transferase; Provisional; Region: PRK10357 1286170013235 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1286170013236 putative C-terminal domain interface [polypeptide binding]; other site 1286170013237 putative GSH binding site (G-site) [chemical binding]; other site 1286170013238 putative dimer interface [polypeptide binding]; other site 1286170013239 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1286170013240 dimer interface [polypeptide binding]; other site 1286170013241 N-terminal domain interface [polypeptide binding]; other site 1286170013242 putative substrate binding pocket (H-site) [chemical binding]; other site 1286170013243 selenocysteine synthase; Provisional; Region: PRK04311 1286170013244 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1286170013245 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1286170013246 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286170013247 catalytic residue [active] 1286170013248 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1286170013249 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1286170013250 G1 box; other site 1286170013251 putative GEF interaction site [polypeptide binding]; other site 1286170013252 GTP/Mg2+ binding site [chemical binding]; other site 1286170013253 Switch I region; other site 1286170013254 G2 box; other site 1286170013255 G3 box; other site 1286170013256 Switch II region; other site 1286170013257 G4 box; other site 1286170013258 G5 box; other site 1286170013259 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1286170013260 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1286170013261 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1286170013262 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1286170013263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1286170013264 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1286170013265 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1286170013266 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1286170013267 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286170013268 Helix-turn-helix domain; Region: HTH_18; pfam12833 1286170013269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170013270 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1286170013271 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1286170013272 intersubunit interface [polypeptide binding]; other site 1286170013273 active site 1286170013274 Zn2+ binding site [ion binding]; other site 1286170013275 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1286170013276 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1286170013277 AP (apurinic/apyrimidinic) site pocket; other site 1286170013278 DNA interaction; other site 1286170013279 Metal-binding active site; metal-binding site 1286170013280 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1286170013281 active site 1286170013282 dimer interface [polypeptide binding]; other site 1286170013283 magnesium binding site [ion binding]; other site 1286170013284 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1286170013285 putative N- and C-terminal domain interface [polypeptide binding]; other site 1286170013286 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1286170013287 putative active site [active] 1286170013288 MgATP binding site [chemical binding]; other site 1286170013289 catalytic site [active] 1286170013290 metal binding site [ion binding]; metal-binding site 1286170013291 putative xylulose binding site [chemical binding]; other site 1286170013292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170013293 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170013294 putative substrate translocation pore; other site 1286170013295 Domain of unknown function (DUF386); Region: DUF386; pfam04074 1286170013296 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1286170013297 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1286170013298 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 1286170013299 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286170013300 putative ligand binding site [chemical binding]; other site 1286170013301 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170013302 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170013303 TM-ABC transporter signature motif; other site 1286170013304 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286170013305 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170013306 Walker A/P-loop; other site 1286170013307 ATP binding site [chemical binding]; other site 1286170013308 Q-loop/lid; other site 1286170013309 ABC transporter signature motif; other site 1286170013310 Walker B; other site 1286170013311 D-loop; other site 1286170013312 H-loop/switch region; other site 1286170013313 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170013314 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286170013315 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286170013316 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286170013317 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1286170013318 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1286170013319 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170013320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170013321 homodimer interface [polypeptide binding]; other site 1286170013322 catalytic residue [active] 1286170013323 alpha-amylase; Reviewed; Region: malS; PRK09505 1286170013324 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1286170013325 active site 1286170013326 catalytic site [active] 1286170013327 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1286170013328 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1286170013329 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1286170013330 putative dimerization interface [polypeptide binding]; other site 1286170013331 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170013332 putative ligand binding site [chemical binding]; other site 1286170013333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170013334 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286170013335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170013336 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170013337 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170013338 TM-ABC transporter signature motif; other site 1286170013339 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1286170013340 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170013341 Walker A/P-loop; other site 1286170013342 ATP binding site [chemical binding]; other site 1286170013343 Q-loop/lid; other site 1286170013344 ABC transporter signature motif; other site 1286170013345 Walker B; other site 1286170013346 D-loop; other site 1286170013347 H-loop/switch region; other site 1286170013348 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170013349 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1286170013350 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1286170013351 putative ligand binding site [chemical binding]; other site 1286170013352 xylose isomerase; Provisional; Region: PRK05474 1286170013353 xylose isomerase; Region: xylose_isom_A; TIGR02630 1286170013354 xylulokinase; Provisional; Region: PRK15027 1286170013355 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1286170013356 N- and C-terminal domain interface [polypeptide binding]; other site 1286170013357 active site 1286170013358 MgATP binding site [chemical binding]; other site 1286170013359 catalytic site [active] 1286170013360 metal binding site [ion binding]; metal-binding site 1286170013361 xylulose binding site [chemical binding]; other site 1286170013362 homodimer interface [polypeptide binding]; other site 1286170013363 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1286170013364 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1286170013365 YsaB-like lipoprotein; Region: YsaB; pfam13983 1286170013366 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1286170013367 dimer interface [polypeptide binding]; other site 1286170013368 motif 1; other site 1286170013369 active site 1286170013370 motif 2; other site 1286170013371 motif 3; other site 1286170013372 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1286170013373 DALR anticodon binding domain; Region: DALR_1; pfam05746 1286170013374 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1286170013375 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170013376 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286170013377 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170013378 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286170013379 DNA-binding site [nucleotide binding]; DNA binding site 1286170013380 RNA-binding motif; other site 1286170013381 Predicted transcriptional regulator [Transcription]; Region: COG2944 1286170013382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286170013383 salt bridge; other site 1286170013384 non-specific DNA binding site [nucleotide binding]; other site 1286170013385 sequence-specific DNA binding site [nucleotide binding]; other site 1286170013386 benzoate transport; Region: 2A0115; TIGR00895 1286170013387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170013388 putative substrate translocation pore; other site 1286170013389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170013390 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1286170013391 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1286170013392 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1286170013393 dimerization interface [polypeptide binding]; other site 1286170013394 ligand binding site [chemical binding]; other site 1286170013395 NADP binding site [chemical binding]; other site 1286170013396 catalytic site [active] 1286170013397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170013398 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170013399 putative substrate translocation pore; other site 1286170013400 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170013401 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1286170013402 substrate binding site [chemical binding]; other site 1286170013403 ATP binding site [chemical binding]; other site 1286170013404 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1286170013405 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170013406 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170013407 DNA binding site [nucleotide binding] 1286170013408 domain linker motif; other site 1286170013409 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1286170013410 putative dimerization interface [polypeptide binding]; other site 1286170013411 putative ligand binding site [chemical binding]; other site 1286170013412 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1286170013413 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1286170013414 ligand binding site [chemical binding]; other site 1286170013415 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1286170013416 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1286170013417 molybdopterin cofactor binding site [chemical binding]; other site 1286170013418 substrate binding site [chemical binding]; other site 1286170013419 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1286170013420 molybdopterin cofactor binding site; other site 1286170013421 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286170013422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170013423 Coenzyme A binding pocket [chemical binding]; other site 1286170013424 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1286170013425 Autotransporter beta-domain; Region: Autotransporter; cl17461 1286170013426 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1286170013427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170013428 putative substrate translocation pore; other site 1286170013429 phosphoethanolamine transferase; Provisional; Region: PRK11560 1286170013430 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1286170013431 Sulfatase; Region: Sulfatase; pfam00884 1286170013432 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286170013433 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1286170013434 peptide binding site [polypeptide binding]; other site 1286170013435 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286170013436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170013437 dimer interface [polypeptide binding]; other site 1286170013438 conserved gate region; other site 1286170013439 putative PBP binding loops; other site 1286170013440 ABC-ATPase subunit interface; other site 1286170013441 dipeptide transporter; Provisional; Region: PRK10913 1286170013442 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1286170013443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170013444 dimer interface [polypeptide binding]; other site 1286170013445 conserved gate region; other site 1286170013446 putative PBP binding loops; other site 1286170013447 ABC-ATPase subunit interface; other site 1286170013448 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1286170013449 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170013450 Walker A/P-loop; other site 1286170013451 ATP binding site [chemical binding]; other site 1286170013452 Q-loop/lid; other site 1286170013453 ABC transporter signature motif; other site 1286170013454 Walker B; other site 1286170013455 D-loop; other site 1286170013456 H-loop/switch region; other site 1286170013457 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286170013458 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1286170013459 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170013460 Walker A/P-loop; other site 1286170013461 ATP binding site [chemical binding]; other site 1286170013462 Q-loop/lid; other site 1286170013463 ABC transporter signature motif; other site 1286170013464 Walker B; other site 1286170013465 D-loop; other site 1286170013466 H-loop/switch region; other site 1286170013467 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286170013468 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 1286170013469 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1286170013470 P-loop; other site 1286170013471 Magnesium ion binding site [ion binding]; other site 1286170013472 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1286170013473 Cellulose synthase-like protein; Region: PLN02893 1286170013474 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1286170013475 DXD motif; other site 1286170013476 PilZ domain; Region: PilZ; pfam07238 1286170013477 cellulose synthase regulator protein; Provisional; Region: PRK11114 1286170013478 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1286170013479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286170013480 TPR motif; other site 1286170013481 binding surface 1286170013482 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1286170013483 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1286170013484 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 1286170013485 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; pfam01270 1286170013486 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1286170013487 active site 1286170013488 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1286170013489 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1286170013490 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1286170013491 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1286170013492 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1286170013493 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1286170013494 cell division protein; Provisional; Region: PRK10037 1286170013495 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286170013496 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1286170013497 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286170013498 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1286170013499 DXD motif; other site 1286170013500 PilZ domain; Region: PilZ; pfam07238 1286170013501 cellulose synthase regulator protein; Provisional; Region: PRK11114 1286170013502 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1286170013503 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1286170013504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286170013505 TPR motif; other site 1286170013506 binding surface 1286170013507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286170013508 binding surface 1286170013509 TPR motif; other site 1286170013510 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1286170013511 putative diguanylate cyclase; Provisional; Region: PRK13561 1286170013512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286170013513 dimerization interface [polypeptide binding]; other site 1286170013514 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170013515 metal binding site [ion binding]; metal-binding site 1286170013516 active site 1286170013517 I-site; other site 1286170013518 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170013519 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1286170013520 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1286170013521 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1286170013522 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1286170013523 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286170013524 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1286170013525 substrate binding site [chemical binding]; other site 1286170013526 ATP binding site [chemical binding]; other site 1286170013527 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1286170013528 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1286170013529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170013530 metabolite-proton symporter; Region: 2A0106; TIGR00883 1286170013531 putative substrate translocation pore; other site 1286170013532 inner membrane protein YhjD; Region: TIGR00766 1286170013533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170013534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170013535 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1286170013536 putative effector binding pocket; other site 1286170013537 putative dimerization interface [polypeptide binding]; other site 1286170013538 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1286170013539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170013540 NAD(P) binding site [chemical binding]; other site 1286170013541 active site 1286170013542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286170013543 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286170013544 trehalase; Provisional; Region: treF; PRK13270 1286170013545 Trehalase; Region: Trehalase; pfam01204 1286170013546 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1286170013547 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 1286170013548 putative active site [active] 1286170013549 metal binding site [ion binding]; metal-binding site 1286170013550 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286170013551 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1286170013552 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1286170013553 putative N-terminal domain interface [polypeptide binding]; other site 1286170013554 putative dimer interface [polypeptide binding]; other site 1286170013555 putative substrate binding pocket (H-site) [chemical binding]; other site 1286170013556 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286170013557 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286170013558 glutathione reductase; Validated; Region: PRK06116 1286170013559 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170013560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170013561 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286170013562 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1286170013563 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1286170013564 active site 1286170013565 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1286170013566 oligopeptidase A; Provisional; Region: PRK10911 1286170013567 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1286170013568 active site 1286170013569 Zn binding site [ion binding]; other site 1286170013570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170013571 S-adenosylmethionine binding site [chemical binding]; other site 1286170013572 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1286170013573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170013574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170013575 Predicted transcriptional regulator [Transcription]; Region: COG1959 1286170013576 Transcriptional regulator; Region: Rrf2; pfam02082 1286170013577 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1286170013578 POT family; Region: PTR2; cl17359 1286170013579 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286170013580 Ligand Binding Site [chemical binding]; other site 1286170013581 universal stress protein UspB; Provisional; Region: PRK04960 1286170013582 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1286170013583 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1286170013584 Predicted flavoproteins [General function prediction only]; Region: COG2081 1286170013585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170013586 FOG: CBS domain [General function prediction only]; Region: COG0517 1286170013587 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1286170013588 Divalent cation transporter; Region: MgtE; pfam01769 1286170013589 nickel responsive regulator; Provisional; Region: PRK02967 1286170013590 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1286170013591 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 1286170013592 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170013593 Walker A/P-loop; other site 1286170013594 ATP binding site [chemical binding]; other site 1286170013595 Q-loop/lid; other site 1286170013596 ABC transporter signature motif; other site 1286170013597 Walker B; other site 1286170013598 D-loop; other site 1286170013599 H-loop/switch region; other site 1286170013600 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 1286170013601 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170013602 Walker A/P-loop; other site 1286170013603 ATP binding site [chemical binding]; other site 1286170013604 Q-loop/lid; other site 1286170013605 ABC transporter signature motif; other site 1286170013606 Walker B; other site 1286170013607 D-loop; other site 1286170013608 H-loop/switch region; other site 1286170013609 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1286170013610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170013611 dimer interface [polypeptide binding]; other site 1286170013612 conserved gate region; other site 1286170013613 putative PBP binding loops; other site 1286170013614 ABC-ATPase subunit interface; other site 1286170013615 nickel transporter permease NikB; Provisional; Region: PRK10352 1286170013616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170013617 dimer interface [polypeptide binding]; other site 1286170013618 conserved gate region; other site 1286170013619 putative PBP binding loops; other site 1286170013620 ABC-ATPase subunit interface; other site 1286170013621 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1286170013622 substrate binding site [chemical binding]; other site 1286170013623 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1286170013624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170013625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170013626 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170013627 dimerization interface [polypeptide binding]; other site 1286170013628 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 1286170013629 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1286170013630 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1286170013631 inhibitor-cofactor binding pocket; inhibition site 1286170013632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170013633 catalytic residue [active] 1286170013634 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1286170013635 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1286170013636 Ligand binding site; other site 1286170013637 Putative Catalytic site; other site 1286170013638 DXD motif; other site 1286170013639 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1286170013640 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1286170013641 active site 1286170013642 substrate binding site [chemical binding]; other site 1286170013643 cosubstrate binding site; other site 1286170013644 catalytic site [active] 1286170013645 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1286170013646 active site 1286170013647 hexamer interface [polypeptide binding]; other site 1286170013648 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1286170013649 NAD binding site [chemical binding]; other site 1286170013650 substrate binding site [chemical binding]; other site 1286170013651 active site 1286170013652 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1286170013653 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1286170013654 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1286170013655 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1286170013656 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1286170013657 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1286170013658 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1286170013659 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1286170013660 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1286170013661 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1286170013662 dimer interface [polypeptide binding]; other site 1286170013663 active site 1286170013664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170013665 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1286170013666 NAD(P) binding site [chemical binding]; other site 1286170013667 active site 1286170013668 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1286170013669 active site 2 [active] 1286170013670 active site 1 [active] 1286170013671 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1286170013672 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1286170013673 dimer interface [polypeptide binding]; other site 1286170013674 active site 1286170013675 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 1286170013676 Predicted exporter [General function prediction only]; Region: COG4258 1286170013677 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1286170013678 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1286170013679 active site 1286170013680 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286170013681 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1286170013682 Ligand binding site; other site 1286170013683 Putative Catalytic site; other site 1286170013684 DXD motif; other site 1286170013685 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1286170013686 putative acyl-acceptor binding pocket; other site 1286170013687 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1286170013688 active site 2 [active] 1286170013689 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1286170013690 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286170013691 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286170013692 acyl-activating enzyme (AAE) consensus motif; other site 1286170013693 acyl-activating enzyme (AAE) consensus motif; other site 1286170013694 active site 1286170013695 AMP binding site [chemical binding]; other site 1286170013696 CoA binding site [chemical binding]; other site 1286170013697 Predicted membrane protein [Function unknown]; Region: COG4648 1286170013698 acyl carrier protein; Provisional; Region: PRK05350 1286170013699 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1286170013700 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1286170013701 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1286170013702 putative acyl-acceptor binding pocket; other site 1286170013703 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1286170013704 major facilitator superfamily transporter; Provisional; Region: PRK05122 1286170013705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170013706 putative substrate translocation pore; other site 1286170013707 hypothetical protein; Provisional; Region: PRK11615 1286170013708 hypothetical protein; Provisional; Region: PRK11212 1286170013709 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1286170013710 CPxP motif; other site 1286170013711 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1286170013712 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286170013713 metal-binding site [ion binding] 1286170013714 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286170013715 Predicted membrane protein [Function unknown]; Region: COG3714 1286170013716 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1286170013717 hypothetical protein; Provisional; Region: PRK10910 1286170013718 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1286170013719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170013720 S-adenosylmethionine binding site [chemical binding]; other site 1286170013721 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1286170013722 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1286170013723 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1286170013724 P loop; other site 1286170013725 GTP binding site [chemical binding]; other site 1286170013726 cell division protein FtsE; Provisional; Region: PRK10908 1286170013727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170013728 Walker A/P-loop; other site 1286170013729 ATP binding site [chemical binding]; other site 1286170013730 Q-loop/lid; other site 1286170013731 ABC transporter signature motif; other site 1286170013732 Walker B; other site 1286170013733 D-loop; other site 1286170013734 H-loop/switch region; other site 1286170013735 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1286170013736 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1286170013737 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1286170013738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286170013739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286170013740 DNA binding residues [nucleotide binding] 1286170013741 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286170013742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170013743 DNA-binding site [nucleotide binding]; DNA binding site 1286170013744 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170013745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170013746 homodimer interface [polypeptide binding]; other site 1286170013747 catalytic residue [active] 1286170013748 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1286170013749 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286170013750 inhibitor-cofactor binding pocket; inhibition site 1286170013751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170013752 catalytic residue [active] 1286170013753 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1286170013754 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1286170013755 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1286170013756 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1286170013757 dimerization interface [polypeptide binding]; other site 1286170013758 ligand binding site [chemical binding]; other site 1286170013759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170013760 Coenzyme A binding pocket [chemical binding]; other site 1286170013761 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1286170013762 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1286170013763 dimerization interface [polypeptide binding]; other site 1286170013764 ligand binding site [chemical binding]; other site 1286170013765 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170013766 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1286170013767 TM-ABC transporter signature motif; other site 1286170013768 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1286170013769 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1286170013770 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1286170013771 TM-ABC transporter signature motif; other site 1286170013772 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1286170013773 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1286170013774 Walker A/P-loop; other site 1286170013775 ATP binding site [chemical binding]; other site 1286170013776 Q-loop/lid; other site 1286170013777 ABC transporter signature motif; other site 1286170013778 Walker B; other site 1286170013779 D-loop; other site 1286170013780 H-loop/switch region; other site 1286170013781 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1286170013782 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1286170013783 Walker A/P-loop; other site 1286170013784 ATP binding site [chemical binding]; other site 1286170013785 Q-loop/lid; other site 1286170013786 ABC transporter signature motif; other site 1286170013787 Walker B; other site 1286170013788 D-loop; other site 1286170013789 H-loop/switch region; other site 1286170013790 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1286170013791 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1286170013792 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1286170013793 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1286170013794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170013795 putative substrate translocation pore; other site 1286170013796 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286170013797 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286170013798 inhibitor site; inhibition site 1286170013799 active site 1286170013800 dimer interface [polypeptide binding]; other site 1286170013801 catalytic residue [active] 1286170013802 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286170013803 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1286170013804 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286170013805 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1286170013806 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286170013807 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1286170013808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170013809 dimer interface [polypeptide binding]; other site 1286170013810 conserved gate region; other site 1286170013811 putative PBP binding loops; other site 1286170013812 ABC-ATPase subunit interface; other site 1286170013813 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286170013814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170013815 dimer interface [polypeptide binding]; other site 1286170013816 conserved gate region; other site 1286170013817 putative PBP binding loops; other site 1286170013818 ABC-ATPase subunit interface; other site 1286170013819 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286170013820 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286170013821 Walker A/P-loop; other site 1286170013822 ATP binding site [chemical binding]; other site 1286170013823 Q-loop/lid; other site 1286170013824 ABC transporter signature motif; other site 1286170013825 Walker B; other site 1286170013826 D-loop; other site 1286170013827 H-loop/switch region; other site 1286170013828 TOBE domain; Region: TOBE_2; pfam08402 1286170013829 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1286170013830 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1286170013831 putative active site [active] 1286170013832 catalytic site [active] 1286170013833 putative metal binding site [ion binding]; other site 1286170013834 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1286170013835 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1286170013836 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1286170013837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170013838 Coenzyme A binding pocket [chemical binding]; other site 1286170013839 putative oxidoreductase; Provisional; Region: PRK10206 1286170013840 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286170013841 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286170013842 Pirin-related protein [General function prediction only]; Region: COG1741 1286170013843 Pirin; Region: Pirin; pfam02678 1286170013844 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1286170013845 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170013846 DNA binding site [nucleotide binding] 1286170013847 domain linker motif; other site 1286170013848 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1286170013849 putative ligand binding site [chemical binding]; other site 1286170013850 putative dimerization interface [polypeptide binding]; other site 1286170013851 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1286170013852 ATP-binding site [chemical binding]; other site 1286170013853 Gluconate-6-phosphate binding site [chemical binding]; other site 1286170013854 low affinity gluconate transporter; Provisional; Region: PRK10472 1286170013855 gluconate transporter; Region: gntP; TIGR00791 1286170013856 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1286170013857 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1286170013858 glycogen branching enzyme; Provisional; Region: PRK05402 1286170013859 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1286170013860 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1286170013861 active site 1286170013862 catalytic site [active] 1286170013863 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1286170013864 glycogen debranching enzyme; Provisional; Region: PRK03705 1286170013865 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1286170013866 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1286170013867 active site 1286170013868 catalytic site [active] 1286170013869 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1286170013870 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1286170013871 ligand binding site; other site 1286170013872 oligomer interface; other site 1286170013873 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1286170013874 dimer interface [polypeptide binding]; other site 1286170013875 N-terminal domain interface [polypeptide binding]; other site 1286170013876 sulfate 1 binding site; other site 1286170013877 glycogen synthase; Provisional; Region: glgA; PRK00654 1286170013878 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1286170013879 ADP-binding pocket [chemical binding]; other site 1286170013880 homodimer interface [polypeptide binding]; other site 1286170013881 glycogen phosphorylase; Provisional; Region: PRK14986 1286170013882 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1286170013883 homodimer interface [polypeptide binding]; other site 1286170013884 active site pocket [active] 1286170013885 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1286170013886 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1286170013887 active site residue [active] 1286170013888 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1286170013889 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1286170013890 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1286170013891 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1286170013892 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1286170013893 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286170013894 transcriptional regulator MalT; Provisional; Region: PRK04841 1286170013895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1286170013896 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170013897 DNA binding residues [nucleotide binding] 1286170013898 dimerization interface [polypeptide binding]; other site 1286170013899 maltodextrin phosphorylase; Provisional; Region: PRK14985 1286170013900 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1286170013901 homodimer interface [polypeptide binding]; other site 1286170013902 active site pocket [active] 1286170013903 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1286170013904 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1286170013905 high-affinity gluconate transporter; Provisional; Region: PRK14984 1286170013906 gluconate transporter; Region: gntP; TIGR00791 1286170013907 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1286170013908 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1286170013909 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1286170013910 DNA utilization protein GntX; Provisional; Region: PRK11595 1286170013911 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286170013912 active site 1286170013913 carboxylesterase BioH; Provisional; Region: PRK10349 1286170013914 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1286170013915 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1286170013916 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1286170013917 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1286170013918 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1286170013919 G1 box; other site 1286170013920 GTP/Mg2+ binding site [chemical binding]; other site 1286170013921 Switch I region; other site 1286170013922 G2 box; other site 1286170013923 G3 box; other site 1286170013924 Switch II region; other site 1286170013925 G4 box; other site 1286170013926 G5 box; other site 1286170013927 Nucleoside recognition; Region: Gate; pfam07670 1286170013928 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1286170013929 Nucleoside recognition; Region: Gate; pfam07670 1286170013930 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1286170013931 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1286170013932 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1286170013933 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1286170013934 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1286170013935 RNA binding site [nucleotide binding]; other site 1286170013936 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1286170013937 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1286170013938 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1286170013939 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1286170013940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170013941 active site 1286170013942 phosphorylation site [posttranslational modification] 1286170013943 intermolecular recognition site; other site 1286170013944 dimerization interface [polypeptide binding]; other site 1286170013945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170013946 DNA binding site [nucleotide binding] 1286170013947 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1286170013948 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286170013949 dimerization interface [polypeptide binding]; other site 1286170013950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170013951 dimer interface [polypeptide binding]; other site 1286170013952 phosphorylation site [posttranslational modification] 1286170013953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170013954 ATP binding site [chemical binding]; other site 1286170013955 Mg2+ binding site [ion binding]; other site 1286170013956 G-X-G motif; other site 1286170013957 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1286170013958 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1286170013959 active site 1286170013960 substrate-binding site [chemical binding]; other site 1286170013961 metal-binding site [ion binding] 1286170013962 ATP binding site [chemical binding]; other site 1286170013963 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1286170013964 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1286170013965 dimerization interface [polypeptide binding]; other site 1286170013966 domain crossover interface; other site 1286170013967 redox-dependent activation switch; other site 1286170013968 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286170013969 RNA binding surface [nucleotide binding]; other site 1286170013970 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1286170013971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170013972 motif II; other site 1286170013973 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1286170013974 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1286170013975 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1286170013976 ADP-ribose binding site [chemical binding]; other site 1286170013977 dimer interface [polypeptide binding]; other site 1286170013978 active site 1286170013979 nudix motif; other site 1286170013980 metal binding site [ion binding]; metal-binding site 1286170013981 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1286170013982 Transglycosylase; Region: Transgly; pfam00912 1286170013983 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1286170013984 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1286170013985 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1286170013986 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1286170013987 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1286170013988 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1286170013989 Secretin and TonB N terminus short domain; Region: STN; smart00965 1286170013990 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1286170013991 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1286170013992 shikimate kinase; Reviewed; Region: aroK; PRK00131 1286170013993 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1286170013994 ADP binding site [chemical binding]; other site 1286170013995 magnesium binding site [ion binding]; other site 1286170013996 putative shikimate binding site; other site 1286170013997 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1286170013998 active site 1286170013999 dimer interface [polypeptide binding]; other site 1286170014000 metal binding site [ion binding]; metal-binding site 1286170014001 cell division protein DamX; Validated; Region: PRK10905 1286170014002 cell division protein DamX; Validated; Region: PRK10905 1286170014003 DNA adenine methylase; Provisional; Region: PRK10904 1286170014004 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1286170014005 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1286170014006 substrate binding site [chemical binding]; other site 1286170014007 hexamer interface [polypeptide binding]; other site 1286170014008 metal binding site [ion binding]; metal-binding site 1286170014009 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1286170014010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170014011 motif II; other site 1286170014012 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1286170014013 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1286170014014 active site 1286170014015 HIGH motif; other site 1286170014016 dimer interface [polypeptide binding]; other site 1286170014017 KMSKS motif; other site 1286170014018 siroheme synthase; Provisional; Region: cysG; PRK10637 1286170014019 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1286170014020 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1286170014021 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1286170014022 active site 1286170014023 SAM binding site [chemical binding]; other site 1286170014024 homodimer interface [polypeptide binding]; other site 1286170014025 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1286170014026 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1286170014027 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170014028 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286170014029 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286170014030 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1286170014031 cytosine deaminase; Provisional; Region: PRK09230 1286170014032 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1286170014033 active site 1286170014034 putative transporter; Provisional; Region: PRK03699 1286170014035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170014036 putative substrate translocation pore; other site 1286170014037 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1286170014038 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1286170014039 substrate binding site [chemical binding]; other site 1286170014040 hypothetical protein; Provisional; Region: PRK10204 1286170014041 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1286170014042 cell filamentation protein Fic; Provisional; Region: PRK10347 1286170014043 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1286170014044 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1286170014045 glutamine binding [chemical binding]; other site 1286170014046 catalytic triad [active] 1286170014047 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1286170014048 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286170014049 inhibitor-cofactor binding pocket; inhibition site 1286170014050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170014051 catalytic residue [active] 1286170014052 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1286170014053 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1286170014054 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1286170014055 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1286170014056 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286170014057 ligand binding site [chemical binding]; other site 1286170014058 flexible hinge region; other site 1286170014059 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286170014060 putative switch regulator; other site 1286170014061 non-specific DNA interactions [nucleotide binding]; other site 1286170014062 DNA binding site [nucleotide binding] 1286170014063 sequence specific DNA binding site [nucleotide binding]; other site 1286170014064 putative cAMP binding site [chemical binding]; other site 1286170014065 hypothetical protein; Provisional; Region: PRK10738 1286170014066 phosphoribulokinase; Provisional; Region: PRK15453 1286170014067 active site 1286170014068 hypothetical protein; Provisional; Region: PRK04966 1286170014069 putative hydrolase; Provisional; Region: PRK10985 1286170014070 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1286170014071 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1286170014072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170014073 Walker A/P-loop; other site 1286170014074 ATP binding site [chemical binding]; other site 1286170014075 Q-loop/lid; other site 1286170014076 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170014077 ABC transporter; Region: ABC_tran_2; pfam12848 1286170014078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286170014079 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1286170014080 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1286170014081 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1286170014082 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1286170014083 TrkA-N domain; Region: TrkA_N; pfam02254 1286170014084 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1286170014085 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 1286170014086 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1286170014087 phi X174 lysis protein; Provisional; Region: PRK02793 1286170014088 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1286170014089 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1286170014090 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1286170014091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1286170014092 YheO-like PAS domain; Region: PAS_6; pfam08348 1286170014093 HTH domain; Region: HTH_22; pfam13309 1286170014094 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1286170014095 sulfur relay protein TusC; Validated; Region: PRK00211 1286170014096 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1286170014097 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1286170014098 S17 interaction site [polypeptide binding]; other site 1286170014099 S8 interaction site; other site 1286170014100 16S rRNA interaction site [nucleotide binding]; other site 1286170014101 streptomycin interaction site [chemical binding]; other site 1286170014102 23S rRNA interaction site [nucleotide binding]; other site 1286170014103 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1286170014104 30S ribosomal protein S7; Validated; Region: PRK05302 1286170014105 elongation factor G; Reviewed; Region: PRK00007 1286170014106 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1286170014107 G1 box; other site 1286170014108 putative GEF interaction site [polypeptide binding]; other site 1286170014109 GTP/Mg2+ binding site [chemical binding]; other site 1286170014110 Switch I region; other site 1286170014111 G2 box; other site 1286170014112 G3 box; other site 1286170014113 Switch II region; other site 1286170014114 G4 box; other site 1286170014115 G5 box; other site 1286170014116 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1286170014117 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1286170014118 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1286170014119 elongation factor Tu; Reviewed; Region: PRK00049 1286170014120 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1286170014121 G1 box; other site 1286170014122 GEF interaction site [polypeptide binding]; other site 1286170014123 GTP/Mg2+ binding site [chemical binding]; other site 1286170014124 Switch I region; other site 1286170014125 G2 box; other site 1286170014126 G3 box; other site 1286170014127 Switch II region; other site 1286170014128 G4 box; other site 1286170014129 G5 box; other site 1286170014130 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1286170014131 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1286170014132 Antibiotic Binding Site [chemical binding]; other site 1286170014133 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1286170014134 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1286170014135 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1286170014136 heme binding site [chemical binding]; other site 1286170014137 ferroxidase pore; other site 1286170014138 ferroxidase diiron center [ion binding]; other site 1286170014139 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1286170014140 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1286170014141 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1286170014142 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1286170014143 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1286170014144 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1286170014145 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1286170014146 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1286170014147 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1286170014148 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1286170014149 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1286170014150 protein-rRNA interface [nucleotide binding]; other site 1286170014151 putative translocon binding site; other site 1286170014152 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1286170014153 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1286170014154 G-X-X-G motif; other site 1286170014155 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1286170014156 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1286170014157 23S rRNA interface [nucleotide binding]; other site 1286170014158 5S rRNA interface [nucleotide binding]; other site 1286170014159 putative antibiotic binding site [chemical binding]; other site 1286170014160 L25 interface [polypeptide binding]; other site 1286170014161 L27 interface [polypeptide binding]; other site 1286170014162 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1286170014163 23S rRNA interface [nucleotide binding]; other site 1286170014164 putative translocon interaction site; other site 1286170014165 signal recognition particle (SRP54) interaction site; other site 1286170014166 L23 interface [polypeptide binding]; other site 1286170014167 trigger factor interaction site; other site 1286170014168 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1286170014169 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1286170014170 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1286170014171 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1286170014172 RNA binding site [nucleotide binding]; other site 1286170014173 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1286170014174 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1286170014175 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1286170014176 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1286170014177 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1286170014178 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1286170014179 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1286170014180 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1286170014181 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1286170014182 23S rRNA interface [nucleotide binding]; other site 1286170014183 5S rRNA interface [nucleotide binding]; other site 1286170014184 L27 interface [polypeptide binding]; other site 1286170014185 L5 interface [polypeptide binding]; other site 1286170014186 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1286170014187 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1286170014188 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1286170014189 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1286170014190 23S rRNA binding site [nucleotide binding]; other site 1286170014191 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1286170014192 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1286170014193 SecY translocase; Region: SecY; pfam00344 1286170014194 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1286170014195 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1286170014196 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1286170014197 30S ribosomal protein S11; Validated; Region: PRK05309 1286170014198 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1286170014199 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1286170014200 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286170014201 RNA binding surface [nucleotide binding]; other site 1286170014202 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1286170014203 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1286170014204 alphaNTD homodimer interface [polypeptide binding]; other site 1286170014205 alphaNTD - beta interaction site [polypeptide binding]; other site 1286170014206 alphaNTD - beta' interaction site [polypeptide binding]; other site 1286170014207 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1286170014208 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1286170014209 hypothetical protein; Provisional; Region: PRK10203 1286170014210 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1286170014211 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1286170014212 DNA binding residues [nucleotide binding] 1286170014213 dimer interface [polypeptide binding]; other site 1286170014214 metal binding site [ion binding]; metal-binding site 1286170014215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1286170014216 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1286170014217 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1286170014218 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1286170014219 TrkA-N domain; Region: TrkA_N; pfam02254 1286170014220 TrkA-C domain; Region: TrkA_C; pfam02080 1286170014221 TrkA-N domain; Region: TrkA_N; pfam02254 1286170014222 TrkA-C domain; Region: TrkA_C; pfam02080 1286170014223 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1286170014224 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1286170014225 putative RNA binding site [nucleotide binding]; other site 1286170014226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170014227 S-adenosylmethionine binding site [chemical binding]; other site 1286170014228 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1286170014229 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1286170014230 putative active site [active] 1286170014231 substrate binding site [chemical binding]; other site 1286170014232 putative cosubstrate binding site; other site 1286170014233 catalytic site [active] 1286170014234 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1286170014235 substrate binding site [chemical binding]; other site 1286170014236 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1286170014237 active site 1286170014238 catalytic residues [active] 1286170014239 metal binding site [ion binding]; metal-binding site 1286170014240 hypothetical protein; Provisional; Region: PRK10736 1286170014241 DNA protecting protein DprA; Region: dprA; TIGR00732 1286170014242 hypothetical protein; Validated; Region: PRK03430 1286170014243 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1286170014244 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1286170014245 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1286170014246 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1286170014247 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1286170014248 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1286170014249 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1286170014250 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1286170014251 shikimate binding site; other site 1286170014252 NAD(P) binding site [chemical binding]; other site 1286170014253 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1286170014254 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1286170014255 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1286170014256 trimer interface [polypeptide binding]; other site 1286170014257 putative metal binding site [ion binding]; other site 1286170014258 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1286170014259 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1286170014260 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1286170014261 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1286170014262 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1286170014263 FMN binding site [chemical binding]; other site 1286170014264 active site 1286170014265 catalytic residues [active] 1286170014266 substrate binding site [chemical binding]; other site 1286170014267 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1286170014268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1286170014269 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1286170014270 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1286170014271 Na binding site [ion binding]; other site 1286170014272 hypothetical protein; Provisional; Region: PRK10633 1286170014273 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1286170014274 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286170014275 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1286170014276 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1286170014277 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1286170014278 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1286170014279 carboxyltransferase (CT) interaction site; other site 1286170014280 biotinylation site [posttranslational modification]; other site 1286170014281 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1286170014282 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1286170014283 active site 1286170014284 trimer interface [polypeptide binding]; other site 1286170014285 dimer interface [polypeptide binding]; other site 1286170014286 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1286170014287 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1286170014288 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1286170014289 Moco binding site; other site 1286170014290 metal coordination site [ion binding]; other site 1286170014291 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1286170014292 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1286170014293 NADP binding site [chemical binding]; other site 1286170014294 dimer interface [polypeptide binding]; other site 1286170014295 regulatory protein CsrD; Provisional; Region: PRK11059 1286170014296 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170014297 metal binding site [ion binding]; metal-binding site 1286170014298 active site 1286170014299 I-site; other site 1286170014300 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170014301 rod shape-determining protein MreB; Provisional; Region: PRK13927 1286170014302 MreB and similar proteins; Region: MreB_like; cd10225 1286170014303 nucleotide binding site [chemical binding]; other site 1286170014304 Mg binding site [ion binding]; other site 1286170014305 putative protofilament interaction site [polypeptide binding]; other site 1286170014306 RodZ interaction site [polypeptide binding]; other site 1286170014307 rod shape-determining protein MreC; Region: mreC; TIGR00219 1286170014308 rod shape-determining protein MreC; Region: MreC; pfam04085 1286170014309 rod shape-determining protein MreD; Provisional; Region: PRK11060 1286170014310 Maf-like protein; Region: Maf; pfam02545 1286170014311 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1286170014312 active site 1286170014313 dimer interface [polypeptide binding]; other site 1286170014314 ribonuclease G; Provisional; Region: PRK11712 1286170014315 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1286170014316 homodimer interface [polypeptide binding]; other site 1286170014317 oligonucleotide binding site [chemical binding]; other site 1286170014318 hypothetical protein; Provisional; Region: PRK10899 1286170014319 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1286170014320 protease TldD; Provisional; Region: tldD; PRK10735 1286170014321 transcriptional regulator; Provisional; Region: PRK10632 1286170014322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170014323 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170014324 putative effector binding pocket; other site 1286170014325 dimerization interface [polypeptide binding]; other site 1286170014326 efflux system membrane protein; Provisional; Region: PRK11594 1286170014327 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1286170014328 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170014329 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170014330 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1286170014331 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1286170014332 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1286170014333 RNAase interaction site [polypeptide binding]; other site 1286170014334 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1286170014335 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1286170014336 arginine repressor; Provisional; Region: PRK05066 1286170014337 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1286170014338 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1286170014339 malate dehydrogenase; Provisional; Region: PRK05086 1286170014340 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1286170014341 NAD binding site [chemical binding]; other site 1286170014342 dimerization interface [polypeptide binding]; other site 1286170014343 Substrate binding site [chemical binding]; other site 1286170014344 transcriptional activator RhaR; Provisional; Region: PRK13501 1286170014345 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286170014346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170014347 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 1286170014348 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 1286170014349 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1286170014350 substrate binding site [chemical binding]; other site 1286170014351 trimer interface [polypeptide binding]; other site 1286170014352 Mn binding site [ion binding]; other site 1286170014353 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1286170014354 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 1286170014355 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1286170014356 trimer interface [polypeptide binding]; other site 1286170014357 substrate binding site [chemical binding]; other site 1286170014358 Mn binding site [ion binding]; other site 1286170014359 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1286170014360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170014361 putative substrate translocation pore; other site 1286170014362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170014363 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286170014364 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1286170014365 inhibitor binding site; inhibition site 1286170014366 catalytic Zn binding site [ion binding]; other site 1286170014367 structural Zn binding site [ion binding]; other site 1286170014368 NADP binding site [chemical binding]; other site 1286170014369 tetramer interface [polypeptide binding]; other site 1286170014370 serine endoprotease; Provisional; Region: PRK10898 1286170014371 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1286170014372 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286170014373 protein binding site [polypeptide binding]; other site 1286170014374 serine endoprotease; Provisional; Region: PRK10139 1286170014375 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1286170014376 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286170014377 protein binding site [polypeptide binding]; other site 1286170014378 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286170014379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1286170014380 hypothetical protein; Provisional; Region: PRK11677 1286170014381 Predicted ATPase [General function prediction only]; Region: COG1485 1286170014382 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1286170014383 23S rRNA interface [nucleotide binding]; other site 1286170014384 L3 interface [polypeptide binding]; other site 1286170014385 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1286170014386 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1286170014387 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1286170014388 C-terminal domain interface [polypeptide binding]; other site 1286170014389 putative GSH binding site (G-site) [chemical binding]; other site 1286170014390 dimer interface [polypeptide binding]; other site 1286170014391 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1286170014392 dimer interface [polypeptide binding]; other site 1286170014393 N-terminal domain interface [polypeptide binding]; other site 1286170014394 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1286170014395 transcriptional regulator NanR; Provisional; Region: PRK03837 1286170014396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170014397 DNA-binding site [nucleotide binding]; DNA binding site 1286170014398 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286170014399 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1286170014400 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1286170014401 inhibitor site; inhibition site 1286170014402 active site 1286170014403 dimer interface [polypeptide binding]; other site 1286170014404 catalytic residue [active] 1286170014405 putative sialic acid transporter; Provisional; Region: PRK03893 1286170014406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170014407 putative substrate translocation pore; other site 1286170014408 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1286170014409 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1286170014410 putative active site cavity [active] 1286170014411 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1286170014412 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286170014413 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1286170014414 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1286170014415 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286170014416 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170014417 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170014418 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1286170014419 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1286170014420 active site 1286170014421 dimer interface [polypeptide binding]; other site 1286170014422 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1286170014423 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1286170014424 active site 1286170014425 FMN binding site [chemical binding]; other site 1286170014426 substrate binding site [chemical binding]; other site 1286170014427 3Fe-4S cluster binding site [ion binding]; other site 1286170014428 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1286170014429 domain interface; other site 1286170014430 radical SAM protein, TIGR01212 family; Region: TIGR01212 1286170014431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170014432 FeS/SAM binding site; other site 1286170014433 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1286170014434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286170014435 putative active site [active] 1286170014436 heme pocket [chemical binding]; other site 1286170014437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170014438 dimer interface [polypeptide binding]; other site 1286170014439 phosphorylation site [posttranslational modification] 1286170014440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170014441 ATP binding site [chemical binding]; other site 1286170014442 Mg2+ binding site [ion binding]; other site 1286170014443 G-X-G motif; other site 1286170014444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170014445 active site 1286170014446 phosphorylation site [posttranslational modification] 1286170014447 intermolecular recognition site; other site 1286170014448 dimerization interface [polypeptide binding]; other site 1286170014449 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1286170014450 putative binding surface; other site 1286170014451 active site 1286170014452 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1286170014453 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1286170014454 conserved cys residue [active] 1286170014455 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1286170014456 Transglycosylase; Region: Transgly; cl17702 1286170014457 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1286170014458 dimerization domain swap beta strand [polypeptide binding]; other site 1286170014459 regulatory protein interface [polypeptide binding]; other site 1286170014460 active site 1286170014461 regulatory phosphorylation site [posttranslational modification]; other site 1286170014462 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1286170014463 AAA domain; Region: AAA_18; pfam13238 1286170014464 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286170014465 active site 1286170014466 phosphorylation site [posttranslational modification] 1286170014467 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1286170014468 30S subunit binding site; other site 1286170014469 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1286170014470 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1286170014471 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1286170014472 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1286170014473 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1286170014474 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1286170014475 Walker A/P-loop; other site 1286170014476 ATP binding site [chemical binding]; other site 1286170014477 Q-loop/lid; other site 1286170014478 ABC transporter signature motif; other site 1286170014479 Walker B; other site 1286170014480 D-loop; other site 1286170014481 H-loop/switch region; other site 1286170014482 OstA-like protein; Region: OstA; cl00844 1286170014483 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1286170014484 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1286170014485 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1286170014486 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1286170014487 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1286170014488 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1286170014489 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1286170014490 putative active site [active] 1286170014491 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1286170014492 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1286170014493 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1286170014494 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1286170014495 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1286170014496 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1286170014497 Walker A/P-loop; other site 1286170014498 ATP binding site [chemical binding]; other site 1286170014499 Q-loop/lid; other site 1286170014500 ABC transporter signature motif; other site 1286170014501 Walker B; other site 1286170014502 D-loop; other site 1286170014503 H-loop/switch region; other site 1286170014504 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1286170014505 conserved hypothetical integral membrane protein; Region: TIGR00056 1286170014506 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1286170014507 mce related protein; Region: MCE; pfam02470 1286170014508 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1286170014509 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1286170014510 anti sigma factor interaction site; other site 1286170014511 regulatory phosphorylation site [posttranslational modification]; other site 1286170014512 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1286170014513 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1286170014514 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1286170014515 hinge; other site 1286170014516 active site 1286170014517 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1286170014518 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1286170014519 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1286170014520 substrate binding pocket [chemical binding]; other site 1286170014521 chain length determination region; other site 1286170014522 substrate-Mg2+ binding site; other site 1286170014523 catalytic residues [active] 1286170014524 aspartate-rich region 1; other site 1286170014525 active site lid residues [active] 1286170014526 aspartate-rich region 2; other site 1286170014527 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1286170014528 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1286170014529 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1286170014530 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286170014531 EamA-like transporter family; Region: EamA; pfam00892 1286170014532 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1286170014533 GTP1/OBG; Region: GTP1_OBG; pfam01018 1286170014534 Obg GTPase; Region: Obg; cd01898 1286170014535 G1 box; other site 1286170014536 GTP/Mg2+ binding site [chemical binding]; other site 1286170014537 Switch I region; other site 1286170014538 G2 box; other site 1286170014539 G3 box; other site 1286170014540 Switch II region; other site 1286170014541 G4 box; other site 1286170014542 G5 box; other site 1286170014543 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1286170014544 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1286170014545 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1286170014546 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1286170014547 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1286170014548 RNA-binding protein YhbY; Provisional; Region: PRK10343 1286170014549 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1286170014550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170014551 S-adenosylmethionine binding site [chemical binding]; other site 1286170014552 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1286170014553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170014554 Walker A motif; other site 1286170014555 ATP binding site [chemical binding]; other site 1286170014556 Walker B motif; other site 1286170014557 arginine finger; other site 1286170014558 Peptidase family M41; Region: Peptidase_M41; pfam01434 1286170014559 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1286170014560 dihydropteroate synthase; Region: DHPS; TIGR01496 1286170014561 substrate binding pocket [chemical binding]; other site 1286170014562 dimer interface [polypeptide binding]; other site 1286170014563 inhibitor binding site; inhibition site 1286170014564 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1286170014565 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1286170014566 active site 1286170014567 substrate binding site [chemical binding]; other site 1286170014568 metal binding site [ion binding]; metal-binding site 1286170014569 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1286170014570 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1286170014571 YfaZ precursor; Region: YfaZ; pfam07437 1286170014572 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1286170014573 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1286170014574 ligand binding site [chemical binding]; other site 1286170014575 flexible hinge region; other site 1286170014576 argininosuccinate synthase; Validated; Region: PRK05370 1286170014577 argininosuccinate synthase; Provisional; Region: PRK13820 1286170014578 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1286170014579 Sm and related proteins; Region: Sm_like; cl00259 1286170014580 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1286170014581 putative oligomer interface [polypeptide binding]; other site 1286170014582 putative RNA binding site [nucleotide binding]; other site 1286170014583 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1286170014584 NusA N-terminal domain; Region: NusA_N; pfam08529 1286170014585 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1286170014586 RNA binding site [nucleotide binding]; other site 1286170014587 homodimer interface [polypeptide binding]; other site 1286170014588 NusA-like KH domain; Region: KH_5; pfam13184 1286170014589 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1286170014590 G-X-X-G motif; other site 1286170014591 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1286170014592 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1286170014593 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1286170014594 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1286170014595 translation initiation factor IF-2; Region: IF-2; TIGR00487 1286170014596 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1286170014597 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1286170014598 G1 box; other site 1286170014599 putative GEF interaction site [polypeptide binding]; other site 1286170014600 GTP/Mg2+ binding site [chemical binding]; other site 1286170014601 Switch I region; other site 1286170014602 G2 box; other site 1286170014603 G3 box; other site 1286170014604 Switch II region; other site 1286170014605 G4 box; other site 1286170014606 G5 box; other site 1286170014607 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1286170014608 Translation-initiation factor 2; Region: IF-2; pfam11987 1286170014609 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1286170014610 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1286170014611 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1286170014612 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1286170014613 RNA binding site [nucleotide binding]; other site 1286170014614 active site 1286170014615 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1286170014616 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1286170014617 16S/18S rRNA binding site [nucleotide binding]; other site 1286170014618 S13e-L30e interaction site [polypeptide binding]; other site 1286170014619 25S rRNA binding site [nucleotide binding]; other site 1286170014620 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1286170014621 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1286170014622 RNase E interface [polypeptide binding]; other site 1286170014623 trimer interface [polypeptide binding]; other site 1286170014624 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1286170014625 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1286170014626 RNase E interface [polypeptide binding]; other site 1286170014627 trimer interface [polypeptide binding]; other site 1286170014628 active site 1286170014629 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1286170014630 putative nucleic acid binding region [nucleotide binding]; other site 1286170014631 G-X-X-G motif; other site 1286170014632 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1286170014633 RNA binding site [nucleotide binding]; other site 1286170014634 domain interface; other site 1286170014635 lipoprotein NlpI; Provisional; Region: PRK11189 1286170014636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286170014637 binding surface 1286170014638 TPR motif; other site 1286170014639 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1286170014640 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1286170014641 ATP binding site [chemical binding]; other site 1286170014642 Mg++ binding site [ion binding]; other site 1286170014643 motif III; other site 1286170014644 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286170014645 nucleotide binding region [chemical binding]; other site 1286170014646 ATP-binding site [chemical binding]; other site 1286170014647 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1286170014648 putative RNA binding site [nucleotide binding]; other site 1286170014649 tryptophan permease; Provisional; Region: PRK10483 1286170014650 aromatic amino acid transport protein; Region: araaP; TIGR00837 1286170014651 hypothetical protein; Provisional; Region: PRK10508 1286170014652 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1286170014653 putative protease; Provisional; Region: PRK15447 1286170014654 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1286170014655 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1286170014656 Peptidase family U32; Region: Peptidase_U32; pfam01136 1286170014657 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1286170014658 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1286170014659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170014660 Coenzyme A binding pocket [chemical binding]; other site 1286170014661 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1286170014662 GIY-YIG motif/motif A; other site 1286170014663 putative active site [active] 1286170014664 putative metal binding site [ion binding]; other site 1286170014665 hypothetical protein; Provisional; Region: PRK03467 1286170014666 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1286170014667 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1286170014668 NAD binding site [chemical binding]; other site 1286170014669 active site 1286170014670 Predicted permease; Region: DUF318; pfam03773 1286170014671 outer membrane lipoprotein; Provisional; Region: PRK11023 1286170014672 BON domain; Region: BON; pfam04972 1286170014673 BON domain; Region: BON; pfam04972 1286170014674 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1286170014675 dimer interface [polypeptide binding]; other site 1286170014676 active site 1286170014677 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1286170014678 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1286170014679 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1286170014680 putative ligand binding site [chemical binding]; other site 1286170014681 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1286170014682 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1286170014683 putative SAM binding site [chemical binding]; other site 1286170014684 putative homodimer interface [polypeptide binding]; other site 1286170014685 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1286170014686 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1286170014687 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1286170014688 intersubunit interface [polypeptide binding]; other site 1286170014689 active site 1286170014690 zinc binding site [ion binding]; other site 1286170014691 Na+ binding site [ion binding]; other site 1286170014692 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1286170014693 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1286170014694 dimer interface [polypeptide binding]; other site 1286170014695 active site 1286170014696 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1286170014697 putative active site [active] 1286170014698 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1286170014699 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1286170014700 active site 1286170014701 dimer interface [polypeptide binding]; other site 1286170014702 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1286170014703 active pocket/dimerization site; other site 1286170014704 active site 1286170014705 phosphorylation site [posttranslational modification] 1286170014706 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1286170014707 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1286170014708 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1286170014709 active site 1286170014710 phosphorylation site [posttranslational modification] 1286170014711 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 1286170014712 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 1286170014713 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1286170014714 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286170014715 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1286170014716 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1286170014717 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1286170014718 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1286170014719 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1286170014720 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286170014721 Glycerate kinase family; Region: Gly_kinase; cl00841 1286170014722 Pirin-related protein [General function prediction only]; Region: COG1741 1286170014723 Pirin; Region: Pirin; pfam02678 1286170014724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170014725 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1286170014726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170014727 dimerization interface [polypeptide binding]; other site 1286170014728 Predicted membrane protein [Function unknown]; Region: COG3152 1286170014729 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1286170014730 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1286170014731 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1286170014732 putative dimer interface [polypeptide binding]; other site 1286170014733 N-terminal domain interface [polypeptide binding]; other site 1286170014734 putative substrate binding pocket (H-site) [chemical binding]; other site 1286170014735 Predicted membrane protein [Function unknown]; Region: COG2259 1286170014736 YqjK-like protein; Region: YqjK; pfam13997 1286170014737 Predicted membrane protein [Function unknown]; Region: COG5393 1286170014738 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1286170014739 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1286170014740 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1286170014741 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286170014742 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1286170014743 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1286170014744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170014745 DNA-binding site [nucleotide binding]; DNA binding site 1286170014746 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286170014747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170014748 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170014749 putative substrate translocation pore; other site 1286170014750 Glucuronate isomerase; Region: UxaC; pfam02614 1286170014751 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1286170014752 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1286170014753 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1286170014754 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1286170014755 serine/threonine transporter SstT; Provisional; Region: PRK13628 1286170014756 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1286170014757 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1286170014758 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286170014759 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286170014760 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1286170014761 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1286170014762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170014763 S-adenosylmethionine binding site [chemical binding]; other site 1286170014764 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1286170014765 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1286170014766 active site 1286170014767 FMN binding site [chemical binding]; other site 1286170014768 2,4-decadienoyl-CoA binding site; other site 1286170014769 catalytic residue [active] 1286170014770 4Fe-4S cluster binding site [ion binding]; other site 1286170014771 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1286170014772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170014773 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1286170014774 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1286170014775 putative N- and C-terminal domain interface [polypeptide binding]; other site 1286170014776 putative active site [active] 1286170014777 putative MgATP binding site [chemical binding]; other site 1286170014778 catalytic site [active] 1286170014779 metal binding site [ion binding]; metal-binding site 1286170014780 putative carbohydrate binding site [chemical binding]; other site 1286170014781 transcriptional regulator LsrR; Provisional; Region: PRK15418 1286170014782 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286170014783 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1286170014784 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286170014785 Walker A/P-loop; other site 1286170014786 ATP binding site [chemical binding]; other site 1286170014787 Q-loop/lid; other site 1286170014788 ABC transporter signature motif; other site 1286170014789 Walker B; other site 1286170014790 D-loop; other site 1286170014791 H-loop/switch region; other site 1286170014792 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286170014793 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170014794 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170014795 TM-ABC transporter signature motif; other site 1286170014796 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170014797 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170014798 TM-ABC transporter signature motif; other site 1286170014799 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1286170014800 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1286170014801 ligand binding site [chemical binding]; other site 1286170014802 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1286170014803 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1286170014804 putative active site; other site 1286170014805 catalytic residue [active] 1286170014806 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1286170014807 Protein of unknown function (DUF796); Region: DUF796; cl01226 1286170014808 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1286170014809 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286170014810 inhibitor-cofactor binding pocket; inhibition site 1286170014811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170014812 catalytic residue [active] 1286170014813 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286170014814 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1286170014815 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1286170014816 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1286170014817 FAD binding pocket [chemical binding]; other site 1286170014818 FAD binding motif [chemical binding]; other site 1286170014819 phosphate binding motif [ion binding]; other site 1286170014820 NAD binding pocket [chemical binding]; other site 1286170014821 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 1286170014822 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1286170014823 DAK2 domain; Region: Dak2; pfam02734 1286170014824 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1286170014825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 1286170014826 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1286170014827 dimerization domain swap beta strand [polypeptide binding]; other site 1286170014828 regulatory protein interface [polypeptide binding]; other site 1286170014829 active site 1286170014830 regulatory phosphorylation site [posttranslational modification]; other site 1286170014831 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1286170014832 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1286170014833 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 1286170014834 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1286170014835 Dak1 domain; Region: Dak1; pfam02733 1286170014836 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1286170014837 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1286170014838 dimer interface [polypeptide binding]; other site 1286170014839 active site 1286170014840 metal binding site [ion binding]; metal-binding site 1286170014841 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 1286170014842 PAS domain; Region: PAS; smart00091 1286170014843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170014844 Walker A motif; other site 1286170014845 ATP binding site [chemical binding]; other site 1286170014846 Walker B motif; other site 1286170014847 arginine finger; other site 1286170014848 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286170014849 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 1286170014850 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1286170014851 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1286170014852 active site 1286170014853 SUMO-1 interface [polypeptide binding]; other site 1286170014854 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1286170014855 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1286170014856 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1286170014857 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1286170014858 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286170014859 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1286170014860 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286170014861 DNA binding residues [nucleotide binding] 1286170014862 DNA primase; Validated; Region: dnaG; PRK05667 1286170014863 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1286170014864 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1286170014865 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1286170014866 active site 1286170014867 metal binding site [ion binding]; metal-binding site 1286170014868 interdomain interaction site; other site 1286170014869 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1286170014870 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1286170014871 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1286170014872 UGMP family protein; Validated; Region: PRK09604 1286170014873 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1286170014874 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1286170014875 Na binding site [ion binding]; other site 1286170014876 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286170014877 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1286170014878 UreF; Region: UreF; pfam01730 1286170014879 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1286170014880 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1286170014881 dimer interface [polypeptide binding]; other site 1286170014882 catalytic residues [active] 1286170014883 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1286170014884 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1286170014885 subunit interactions [polypeptide binding]; other site 1286170014886 active site 1286170014887 flap region; other site 1286170014888 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1286170014889 gamma-beta subunit interface [polypeptide binding]; other site 1286170014890 alpha-beta subunit interface [polypeptide binding]; other site 1286170014891 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1286170014892 alpha-gamma subunit interface [polypeptide binding]; other site 1286170014893 beta-gamma subunit interface [polypeptide binding]; other site 1286170014894 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1286170014895 benzoate transport; Region: 2A0115; TIGR00895 1286170014896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170014897 putative substrate translocation pore; other site 1286170014898 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1286170014899 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1286170014900 homooctamer interface [polypeptide binding]; other site 1286170014901 active site 1286170014902 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1286170014903 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1286170014904 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1286170014905 active site 1286170014906 NTP binding site [chemical binding]; other site 1286170014907 metal binding triad [ion binding]; metal-binding site 1286170014908 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1286170014909 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286170014910 Zn2+ binding site [ion binding]; other site 1286170014911 Mg2+ binding site [ion binding]; other site 1286170014912 SH3 domain-containing protein; Provisional; Region: PRK10884 1286170014913 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1286170014914 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1286170014915 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1286170014916 putative active site [active] 1286170014917 putative metal binding residues [ion binding]; other site 1286170014918 signature motif; other site 1286170014919 putative triphosphate binding site [ion binding]; other site 1286170014920 CHAD domain; Region: CHAD; pfam05235 1286170014921 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1286170014922 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1286170014923 metal binding triad; other site 1286170014924 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1286170014925 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1286170014926 metal binding triad; other site 1286170014927 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1286170014928 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1286170014929 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1286170014930 putative ribose interaction site [chemical binding]; other site 1286170014931 putative ADP binding site [chemical binding]; other site 1286170014932 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1286170014933 active site 1286170014934 nucleotide binding site [chemical binding]; other site 1286170014935 HIGH motif; other site 1286170014936 KMSKS motif; other site 1286170014937 Glycogen synthesis protein; Region: GlgS; cl11663 1286170014938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1286170014939 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1286170014940 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1286170014941 zinc transporter ZupT; Provisional; Region: PRK04201 1286170014942 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1286170014943 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1286170014944 putative active site [active] 1286170014945 metal binding site [ion binding]; metal-binding site 1286170014946 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1286170014947 hypothetical protein; Provisional; Region: PRK11653 1286170014948 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1286170014949 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1286170014950 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1286170014951 dimer interface [polypeptide binding]; other site 1286170014952 ADP-ribose binding site [chemical binding]; other site 1286170014953 active site 1286170014954 nudix motif; other site 1286170014955 metal binding site [ion binding]; metal-binding site 1286170014956 putative dehydrogenase; Provisional; Region: PRK11039 1286170014957 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1286170014958 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286170014959 active site 1286170014960 metal binding site [ion binding]; metal-binding site 1286170014961 hexamer interface [polypeptide binding]; other site 1286170014962 esterase YqiA; Provisional; Region: PRK11071 1286170014963 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1286170014964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170014965 ATP binding site [chemical binding]; other site 1286170014966 Mg2+ binding site [ion binding]; other site 1286170014967 G-X-G motif; other site 1286170014968 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1286170014969 anchoring element; other site 1286170014970 dimer interface [polypeptide binding]; other site 1286170014971 ATP binding site [chemical binding]; other site 1286170014972 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1286170014973 active site 1286170014974 metal binding site [ion binding]; metal-binding site 1286170014975 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1286170014976 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1286170014977 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1286170014978 sensor protein QseC; Provisional; Region: PRK10337 1286170014979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170014980 dimer interface [polypeptide binding]; other site 1286170014981 phosphorylation site [posttranslational modification] 1286170014982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170014983 ATP binding site [chemical binding]; other site 1286170014984 Mg2+ binding site [ion binding]; other site 1286170014985 G-X-G motif; other site 1286170014986 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1286170014987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170014988 active site 1286170014989 phosphorylation site [posttranslational modification] 1286170014990 intermolecular recognition site; other site 1286170014991 dimerization interface [polypeptide binding]; other site 1286170014992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286170014993 DNA binding site [nucleotide binding] 1286170014994 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1286170014995 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170014996 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1286170014997 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1286170014998 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1286170014999 CAP-like domain; other site 1286170015000 active site 1286170015001 primary dimer interface [polypeptide binding]; other site 1286170015002 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1286170015003 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1286170015004 putative acyl-acceptor binding pocket; other site 1286170015005 FtsI repressor; Provisional; Region: PRK10883 1286170015006 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1286170015007 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1286170015008 hypothetical protein; Provisional; Region: PRK01254 1286170015009 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1286170015010 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1286170015011 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170015012 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170015013 active site 1286170015014 catalytic tetrad [active] 1286170015015 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1286170015016 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1286170015017 dimer interface [polypeptide binding]; other site 1286170015018 active site 1286170015019 metal binding site [ion binding]; metal-binding site 1286170015020 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1286170015021 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170015022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170015023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170015024 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286170015025 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286170015026 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1286170015027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170015028 dimer interface [polypeptide binding]; other site 1286170015029 conserved gate region; other site 1286170015030 putative PBP binding loops; other site 1286170015031 ABC-ATPase subunit interface; other site 1286170015032 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1286170015033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170015034 Walker A/P-loop; other site 1286170015035 ATP binding site [chemical binding]; other site 1286170015036 Q-loop/lid; other site 1286170015037 ABC transporter signature motif; other site 1286170015038 Walker B; other site 1286170015039 D-loop; other site 1286170015040 H-loop/switch region; other site 1286170015041 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286170015042 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1286170015043 cystathionine beta-lyase; Provisional; Region: PRK08114 1286170015044 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286170015045 homodimer interface [polypeptide binding]; other site 1286170015046 substrate-cofactor binding pocket; other site 1286170015047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170015048 catalytic residue [active] 1286170015049 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1286170015050 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1286170015051 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1286170015052 hypothetical protein; Provisional; Region: PRK05208 1286170015053 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170015054 active site 1286170015055 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170015056 catalytic tetrad [active] 1286170015057 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1286170015058 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286170015059 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1286170015060 putative S-transferase; Provisional; Region: PRK11752 1286170015061 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1286170015062 C-terminal domain interface [polypeptide binding]; other site 1286170015063 GSH binding site (G-site) [chemical binding]; other site 1286170015064 dimer interface [polypeptide binding]; other site 1286170015065 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1286170015066 dimer interface [polypeptide binding]; other site 1286170015067 N-terminal domain interface [polypeptide binding]; other site 1286170015068 active site 1286170015069 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1286170015070 Thioredoxin; Region: Thioredoxin_4; cl17273 1286170015071 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1286170015072 CHAP domain; Region: CHAP; pfam05257 1286170015073 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1286170015074 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1286170015075 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170015076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170015077 homodimer interface [polypeptide binding]; other site 1286170015078 catalytic residue [active] 1286170015079 putative aminotransferase; Provisional; Region: PRK12403 1286170015080 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286170015081 inhibitor-cofactor binding pocket; inhibition site 1286170015082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170015083 catalytic residue [active] 1286170015084 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1286170015085 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1286170015086 NAD(P) binding site [chemical binding]; other site 1286170015087 catalytic residues [active] 1286170015088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170015089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170015090 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1286170015091 putative substrate binding pocket [chemical binding]; other site 1286170015092 dimerization interface [polypeptide binding]; other site 1286170015093 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1286170015094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170015095 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286170015096 homotrimer interaction site [polypeptide binding]; other site 1286170015097 putative active site [active] 1286170015098 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1286170015099 acetylornithine deacetylase; Provisional; Region: PRK07522 1286170015100 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1286170015101 metal binding site [ion binding]; metal-binding site 1286170015102 putative dimer interface [polypeptide binding]; other site 1286170015103 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1286170015104 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1286170015105 Na binding site [ion binding]; other site 1286170015106 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1286170015107 putative NAD(P) binding site [chemical binding]; other site 1286170015108 homodimer interface [polypeptide binding]; other site 1286170015109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170015110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170015111 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 1286170015112 putative effector binding pocket; other site 1286170015113 putative dimerization interface [polypeptide binding]; other site 1286170015114 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1286170015115 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286170015116 homodimer interface [polypeptide binding]; other site 1286170015117 substrate-cofactor binding pocket; other site 1286170015118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170015119 catalytic residue [active] 1286170015120 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1286170015121 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1286170015122 dimer interface [polypeptide binding]; other site 1286170015123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170015124 catalytic residue [active] 1286170015125 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1286170015126 FOG: CBS domain [General function prediction only]; Region: COG0517 1286170015127 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286170015128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170015129 dimer interface [polypeptide binding]; other site 1286170015130 conserved gate region; other site 1286170015131 putative PBP binding loops; other site 1286170015132 ABC-ATPase subunit interface; other site 1286170015133 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286170015134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170015135 Walker A/P-loop; other site 1286170015136 ATP binding site [chemical binding]; other site 1286170015137 Q-loop/lid; other site 1286170015138 ABC transporter signature motif; other site 1286170015139 Walker B; other site 1286170015140 D-loop; other site 1286170015141 H-loop/switch region; other site 1286170015142 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170015143 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170015144 substrate binding pocket [chemical binding]; other site 1286170015145 membrane-bound complex binding site; other site 1286170015146 hinge residues; other site 1286170015147 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286170015148 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286170015149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170015150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170015151 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1286170015152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015153 galactoside permease; Reviewed; Region: lacY; PRK09528 1286170015154 putative substrate translocation pore; other site 1286170015155 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1286170015156 DJ-1 family protein; Region: not_thiJ; TIGR01383 1286170015157 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1286170015158 conserved cys residue [active] 1286170015159 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1286170015160 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1286170015161 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1286170015162 PapC N-terminal domain; Region: PapC_N; pfam13954 1286170015163 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1286170015164 PapC C-terminal domain; Region: PapC_C; pfam13953 1286170015165 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1286170015166 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1286170015167 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1286170015168 Fimbrial protein; Region: Fimbrial; cl01416 1286170015169 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286170015170 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170015171 DNA binding residues [nucleotide binding] 1286170015172 dimerization interface [polypeptide binding]; other site 1286170015173 Fimbrial protein; Region: Fimbrial; cl01416 1286170015174 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1286170015175 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1286170015176 PapC N-terminal domain; Region: PapC_N; pfam13954 1286170015177 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1286170015178 PapC C-terminal domain; Region: PapC_C; pfam13953 1286170015179 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 1286170015180 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1286170015181 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1286170015182 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1286170015183 Fimbrial protein; Region: Fimbrial; pfam00419 1286170015184 PapG chaperone-binding domain; Region: PapG_C; pfam03628 1286170015185 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170015186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1286170015187 DNA binding site [nucleotide binding] 1286170015188 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1286170015189 ornithine decarboxylase; Provisional; Region: PRK13578 1286170015190 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1286170015191 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1286170015192 homodimer interface [polypeptide binding]; other site 1286170015193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170015194 catalytic residue [active] 1286170015195 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1286170015196 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1286170015197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170015198 active site 1286170015199 phosphorylation site [posttranslational modification] 1286170015200 intermolecular recognition site; other site 1286170015201 dimerization interface [polypeptide binding]; other site 1286170015202 Transcriptional regulator; Region: CitT; pfam12431 1286170015203 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1286170015204 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1286170015205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286170015206 putative active site [active] 1286170015207 heme pocket [chemical binding]; other site 1286170015208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170015209 ATP binding site [chemical binding]; other site 1286170015210 Mg2+ binding site [ion binding]; other site 1286170015211 G-X-G motif; other site 1286170015212 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1286170015213 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1286170015214 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1286170015215 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1286170015216 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1286170015217 putative active site [active] 1286170015218 (T/H)XGH motif; other site 1286170015219 citrate lyase subunit gamma; Provisional; Region: PRK13253 1286170015220 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1286170015221 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1286170015222 Coenzyme A transferase; Region: CoA_trans; cl17247 1286170015223 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1286170015224 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1286170015225 nucleoside transporter; Region: 2A0110; TIGR00889 1286170015226 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1286170015227 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1286170015228 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286170015229 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286170015230 catalytic residue [active] 1286170015231 oxidative damage protection protein; Provisional; Region: PRK05408 1286170015232 adenine DNA glycosylase; Provisional; Region: PRK10880 1286170015233 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1286170015234 minor groove reading motif; other site 1286170015235 helix-hairpin-helix signature motif; other site 1286170015236 substrate binding pocket [chemical binding]; other site 1286170015237 active site 1286170015238 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1286170015239 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1286170015240 DNA binding and oxoG recognition site [nucleotide binding] 1286170015241 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1286170015242 hypothetical protein; Provisional; Region: PRK11702 1286170015243 hypothetical protein; Provisional; Region: PRK10626 1286170015244 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1286170015245 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1286170015246 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286170015247 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286170015248 TM-ABC transporter signature motif; other site 1286170015249 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286170015250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170015251 Walker A/P-loop; other site 1286170015252 ATP binding site [chemical binding]; other site 1286170015253 Q-loop/lid; other site 1286170015254 ABC transporter signature motif; other site 1286170015255 Walker B; other site 1286170015256 D-loop; other site 1286170015257 H-loop/switch region; other site 1286170015258 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1286170015259 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1286170015260 putative ligand binding site [chemical binding]; other site 1286170015261 HemN family oxidoreductase; Provisional; Region: PRK05660 1286170015262 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286170015263 FeS/SAM binding site; other site 1286170015264 HemN C-terminal domain; Region: HemN_C; pfam06969 1286170015265 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1286170015266 active site 1286170015267 dimerization interface [polypeptide binding]; other site 1286170015268 hypothetical protein; Validated; Region: PRK05090 1286170015269 YGGT family; Region: YGGT; pfam02325 1286170015270 Predicted integral membrane protein [Function unknown]; Region: COG0762 1286170015271 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1286170015272 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286170015273 catalytic residue [active] 1286170015274 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1286170015275 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1286170015276 Walker A motif; other site 1286170015277 ATP binding site [chemical binding]; other site 1286170015278 Walker B motif; other site 1286170015279 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1286170015280 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170015281 DNA binding residues [nucleotide binding] 1286170015282 dimerization interface [polypeptide binding]; other site 1286170015283 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1286170015284 hypothetical protein; Validated; Region: PRK00228 1286170015285 glutathione synthetase; Provisional; Region: PRK05246 1286170015286 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1286170015287 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1286170015288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1286170015289 RNA methyltransferase, RsmE family; Region: TIGR00046 1286170015290 DNA-specific endonuclease I; Provisional; Region: PRK15137 1286170015291 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1286170015292 hypothetical protein; Provisional; Region: PRK04860 1286170015293 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1286170015294 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1286170015295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015296 putative substrate translocation pore; other site 1286170015297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015298 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1286170015299 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1286170015300 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1286170015301 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1286170015302 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 1286170015303 Virulence promoting factor; Region: YqgB; pfam11036 1286170015304 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1286170015305 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1286170015306 dimer interface [polypeptide binding]; other site 1286170015307 active site 1286170015308 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286170015309 catalytic residues [active] 1286170015310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1286170015311 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1286170015312 agmatinase; Region: agmatinase; TIGR01230 1286170015313 oligomer interface [polypeptide binding]; other site 1286170015314 putative active site [active] 1286170015315 Mn binding site [ion binding]; other site 1286170015316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015317 putative substrate translocation pore; other site 1286170015318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170015319 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1286170015320 [2Fe-2S] cluster binding site [ion binding]; other site 1286170015321 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1286170015322 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1286170015323 [2Fe-2S] cluster binding site [ion binding]; other site 1286170015324 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1286170015325 hydrophobic ligand binding site; other site 1286170015326 short chain dehydrogenase; Provisional; Region: PRK12939 1286170015327 classical (c) SDRs; Region: SDR_c; cd05233 1286170015328 NAD(P) binding site [chemical binding]; other site 1286170015329 active site 1286170015330 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286170015331 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286170015332 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286170015333 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286170015334 active site 1286170015335 metal binding site [ion binding]; metal-binding site 1286170015336 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1286170015337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170015338 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170015339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015340 putative substrate translocation pore; other site 1286170015341 Cupin domain; Region: Cupin_2; pfam07883 1286170015342 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1286170015343 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286170015344 short chain dehydrogenase; Provisional; Region: PRK07062 1286170015345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170015346 NAD(P) binding site [chemical binding]; other site 1286170015347 active site 1286170015348 L-aspartate dehydrogenase; Provisional; Region: PRK13303 1286170015349 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1286170015350 Domain of unknown function DUF108; Region: DUF108; pfam01958 1286170015351 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286170015352 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1286170015353 NAD(P) binding site [chemical binding]; other site 1286170015354 catalytic residues [active] 1286170015355 hypothetical protein; Provisional; Region: PRK07064 1286170015356 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286170015357 PYR/PP interface [polypeptide binding]; other site 1286170015358 dimer interface [polypeptide binding]; other site 1286170015359 TPP binding site [chemical binding]; other site 1286170015360 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286170015361 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1286170015362 TPP-binding site [chemical binding]; other site 1286170015363 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1286170015364 transketolase; Reviewed; Region: PRK12753 1286170015365 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1286170015366 TPP-binding site [chemical binding]; other site 1286170015367 dimer interface [polypeptide binding]; other site 1286170015368 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286170015369 PYR/PP interface [polypeptide binding]; other site 1286170015370 dimer interface [polypeptide binding]; other site 1286170015371 TPP binding site [chemical binding]; other site 1286170015372 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286170015373 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1286170015374 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1286170015375 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1286170015376 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1286170015377 Phosphoglycerate kinase; Region: PGK; pfam00162 1286170015378 substrate binding site [chemical binding]; other site 1286170015379 hinge regions; other site 1286170015380 ADP binding site [chemical binding]; other site 1286170015381 catalytic site [active] 1286170015382 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1286170015383 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1286170015384 active site 1286170015385 intersubunit interface [polypeptide binding]; other site 1286170015386 zinc binding site [ion binding]; other site 1286170015387 Na+ binding site [ion binding]; other site 1286170015388 mechanosensitive channel MscS; Provisional; Region: PRK10334 1286170015389 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286170015390 arginine exporter protein; Provisional; Region: PRK09304 1286170015391 oxidative stress defense protein; Provisional; Region: PRK11087 1286170015392 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1286170015393 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1286170015394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170015395 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1286170015396 putative dimerization interface [polypeptide binding]; other site 1286170015397 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1286170015398 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286170015399 active site 1286170015400 dimer interface [polypeptide binding]; other site 1286170015401 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1286170015402 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1286170015403 ligand binding site [chemical binding]; other site 1286170015404 NAD binding site [chemical binding]; other site 1286170015405 tetramer interface [polypeptide binding]; other site 1286170015406 catalytic site [active] 1286170015407 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1286170015408 L-serine binding site [chemical binding]; other site 1286170015409 ACT domain interface; other site 1286170015410 hypothetical protein; Provisional; Region: PRK09867 1286170015411 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1286170015412 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1286170015413 Z-ring-associated protein; Provisional; Region: PRK10972 1286170015414 hypothetical protein; Reviewed; Region: PRK01736 1286170015415 proline aminopeptidase P II; Provisional; Region: PRK10879 1286170015416 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1286170015417 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1286170015418 active site 1286170015419 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1286170015420 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1286170015421 oxidoreductase; Provisional; Region: PRK08013 1286170015422 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1286170015423 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1286170015424 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286170015425 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1286170015426 lipoyl attachment site [posttranslational modification]; other site 1286170015427 glycine dehydrogenase; Provisional; Region: PRK05367 1286170015428 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1286170015429 tetramer interface [polypeptide binding]; other site 1286170015430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170015431 catalytic residue [active] 1286170015432 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1286170015433 tetramer interface [polypeptide binding]; other site 1286170015434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170015435 catalytic residue [active] 1286170015436 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 1286170015437 classical (c) SDRs; Region: SDR_c; cd05233 1286170015438 NAD(P) binding site [chemical binding]; other site 1286170015439 active site 1286170015440 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1286170015441 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286170015442 catalytic residues [active] 1286170015443 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 1286170015444 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1286170015445 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1286170015446 catalytic residues [active] 1286170015447 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1286170015448 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1286170015449 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1286170015450 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1286170015451 DsbD alpha interface [polypeptide binding]; other site 1286170015452 catalytic residues [active] 1286170015453 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1286170015454 beta-galactosidase; Region: BGL; TIGR03356 1286170015455 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286170015456 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170015457 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170015458 putative active site [active] 1286170015459 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1286170015460 hemolysin; Provisional; Region: PRK15087 1286170015461 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1286170015462 putative global regulator; Reviewed; Region: PRK09559 1286170015463 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1286170015464 hypothetical protein; Provisional; Region: PRK10878 1286170015465 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1286170015466 flavodoxin FldB; Provisional; Region: PRK12359 1286170015467 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1286170015468 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1286170015469 active site 1286170015470 Int/Topo IB signature motif; other site 1286170015471 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1286170015472 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1286170015473 dimerization domain [polypeptide binding]; other site 1286170015474 dimer interface [polypeptide binding]; other site 1286170015475 catalytic residues [active] 1286170015476 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1286170015477 DHH family; Region: DHH; pfam01368 1286170015478 DHHA1 domain; Region: DHHA1; pfam02272 1286170015479 peptide chain release factor 2; Provisional; Region: PRK08787 1286170015480 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1286170015481 RF-1 domain; Region: RF-1; pfam00472 1286170015482 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1286170015483 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1286170015484 dimer interface [polypeptide binding]; other site 1286170015485 putative anticodon binding site; other site 1286170015486 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1286170015487 motif 1; other site 1286170015488 active site 1286170015489 motif 2; other site 1286170015490 motif 3; other site 1286170015491 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1286170015492 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1286170015493 active site 1286170015494 metal binding site [ion binding]; metal-binding site 1286170015495 nudix motif; other site 1286170015496 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286170015497 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286170015498 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1286170015499 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286170015500 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286170015501 active site 1286170015502 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286170015503 active site 1286170015504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015505 putative substrate translocation pore; other site 1286170015506 POT family; Region: PTR2; cl17359 1286170015507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170015508 acetoin reductases; Region: 23BDH; TIGR02415 1286170015509 NAD(P) binding site [chemical binding]; other site 1286170015510 active site 1286170015511 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1286170015512 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170015513 DNA binding residues [nucleotide binding] 1286170015514 dimerization interface [polypeptide binding]; other site 1286170015515 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 1286170015516 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1286170015517 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1286170015518 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1286170015519 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170015520 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170015521 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1286170015522 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1286170015523 enterobactin exporter EntS; Provisional; Region: PRK10489 1286170015524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015525 putative substrate translocation pore; other site 1286170015526 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1286170015527 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286170015528 Coenzyme A binding pocket [chemical binding]; other site 1286170015529 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286170015530 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170015531 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1286170015532 mannosyl binding site [chemical binding]; other site 1286170015533 Fimbrial protein; Region: Fimbrial; cl01416 1286170015534 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1286170015535 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1286170015536 outer membrane usher protein; Provisional; Region: PRK15193 1286170015537 PapC N-terminal domain; Region: PapC_N; pfam13954 1286170015538 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1286170015539 PapC C-terminal domain; Region: PapC_C; pfam13953 1286170015540 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1286170015541 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1286170015542 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1286170015543 Fimbrial protein; Region: Fimbrial; cl01416 1286170015544 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 1286170015545 Int/Topo IB signature motif; other site 1286170015546 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 1286170015547 Int/Topo IB signature motif; other site 1286170015548 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286170015549 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286170015550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286170015551 putative DNA binding site [nucleotide binding]; other site 1286170015552 putative Zn2+ binding site [ion binding]; other site 1286170015553 AsnC family; Region: AsnC_trans_reg; pfam01037 1286170015554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015555 metabolite-proton symporter; Region: 2A0106; TIGR00883 1286170015556 putative substrate translocation pore; other site 1286170015557 Flavin Reductases; Region: FlaRed; cl00801 1286170015558 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1286170015559 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1286170015560 FMN-binding pocket [chemical binding]; other site 1286170015561 flavin binding motif; other site 1286170015562 phosphate binding motif [ion binding]; other site 1286170015563 beta-alpha-beta structure motif; other site 1286170015564 NAD binding pocket [chemical binding]; other site 1286170015565 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1286170015566 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286170015567 catalytic loop [active] 1286170015568 iron binding site [ion binding]; other site 1286170015569 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1286170015570 classical (c) SDRs; Region: SDR_c; cd05233 1286170015571 NAD(P) binding site [chemical binding]; other site 1286170015572 active site 1286170015573 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1286170015574 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1286170015575 [2Fe-2S] cluster binding site [ion binding]; other site 1286170015576 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1286170015577 putative alpha subunit interface [polypeptide binding]; other site 1286170015578 putative active site [active] 1286170015579 putative substrate binding site [chemical binding]; other site 1286170015580 Fe binding site [ion binding]; other site 1286170015581 SnoaL-like domain; Region: SnoaL_4; pfam13577 1286170015582 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286170015583 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286170015584 active site 1286170015585 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1286170015586 Amidase; Region: Amidase; cl11426 1286170015587 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286170015588 MarR family; Region: MarR_2; pfam12802 1286170015589 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1286170015590 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286170015591 MarR family; Region: MarR; pfam01047 1286170015592 MarR family; Region: MarR_2; cl17246 1286170015593 EamA-like transporter family; Region: EamA; pfam00892 1286170015594 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286170015595 EamA-like transporter family; Region: EamA; pfam00892 1286170015596 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1286170015597 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1286170015598 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286170015599 dimerization interface [polypeptide binding]; other site 1286170015600 putative DNA binding site [nucleotide binding]; other site 1286170015601 putative Zn2+ binding site [ion binding]; other site 1286170015602 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1286170015603 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1286170015604 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1286170015605 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1286170015606 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1286170015607 PapC N-terminal domain; Region: PapC_N; pfam13954 1286170015608 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1286170015609 PapC C-terminal domain; Region: PapC_C; pfam13953 1286170015610 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1286170015611 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1286170015612 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286170015613 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286170015614 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286170015615 DNA binding residues [nucleotide binding] 1286170015616 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170015617 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170015618 active site 1286170015619 catalytic tetrad [active] 1286170015620 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1286170015621 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1286170015622 Predicted membrane protein [Function unknown]; Region: COG4125 1286170015623 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1286170015624 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1286170015625 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170015626 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170015627 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286170015628 dimerization interface [polypeptide binding]; other site 1286170015629 putative acyltransferase; Provisional; Region: PRK05790 1286170015630 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286170015631 dimer interface [polypeptide binding]; other site 1286170015632 active site 1286170015633 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1286170015634 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1286170015635 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1286170015636 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1286170015637 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1286170015638 NADP binding site [chemical binding]; other site 1286170015639 homodimer interface [polypeptide binding]; other site 1286170015640 active site 1286170015641 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1286170015642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015643 putative substrate translocation pore; other site 1286170015644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015645 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170015646 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170015647 DNA binding site [nucleotide binding] 1286170015648 domain linker motif; other site 1286170015649 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1286170015650 putative dimerization interface [polypeptide binding]; other site 1286170015651 putative ligand binding site [chemical binding]; other site 1286170015652 galactoside permease; Reviewed; Region: lacY; PRK09528 1286170015653 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1286170015654 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1286170015655 substrate binding [chemical binding]; other site 1286170015656 active site 1286170015657 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1286170015658 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1286170015659 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1286170015660 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286170015661 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286170015662 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286170015663 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286170015664 Walker A/P-loop; other site 1286170015665 ATP binding site [chemical binding]; other site 1286170015666 Q-loop/lid; other site 1286170015667 ABC transporter signature motif; other site 1286170015668 Walker B; other site 1286170015669 D-loop; other site 1286170015670 H-loop/switch region; other site 1286170015671 TOBE domain; Region: TOBE_2; pfam08402 1286170015672 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286170015673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170015674 dimer interface [polypeptide binding]; other site 1286170015675 conserved gate region; other site 1286170015676 putative PBP binding loops; other site 1286170015677 ABC-ATPase subunit interface; other site 1286170015678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170015679 dimer interface [polypeptide binding]; other site 1286170015680 conserved gate region; other site 1286170015681 putative PBP binding loops; other site 1286170015682 ABC-ATPase subunit interface; other site 1286170015683 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1286170015684 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1286170015685 aspartate racemase; Region: asp_race; TIGR00035 1286170015686 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1286170015687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170015688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286170015689 dimerization interface [polypeptide binding]; other site 1286170015690 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1286170015691 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1286170015692 active site 1286170015693 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286170015694 substrate binding site [chemical binding]; other site 1286170015695 catalytic residues [active] 1286170015696 dimer interface [polypeptide binding]; other site 1286170015697 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170015698 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170015699 DNA binding site [nucleotide binding] 1286170015700 domain linker motif; other site 1286170015701 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1286170015702 dimerization interface (closed form) [polypeptide binding]; other site 1286170015703 ligand binding site [chemical binding]; other site 1286170015704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286170015705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170015706 Coenzyme A binding pocket [chemical binding]; other site 1286170015707 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1286170015708 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170015709 DNA binding site [nucleotide binding] 1286170015710 domain linker motif; other site 1286170015711 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1286170015712 dimerization interface (closed form) [polypeptide binding]; other site 1286170015713 ligand binding site [chemical binding]; other site 1286170015714 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1286170015715 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1286170015716 putative acyl-acceptor binding pocket; other site 1286170015717 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1286170015718 acyl-activating enzyme (AAE) consensus motif; other site 1286170015719 putative AMP binding site [chemical binding]; other site 1286170015720 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1286170015721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015722 putative substrate translocation pore; other site 1286170015723 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286170015724 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286170015725 active site 1286170015726 catalytic tetrad [active] 1286170015727 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1286170015728 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1286170015729 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1286170015730 putative DNA-binding cleft [nucleotide binding]; other site 1286170015731 putative DNA clevage site; other site 1286170015732 molecular lever; other site 1286170015733 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1286170015734 putative active site [active] 1286170015735 Ap4A binding site [chemical binding]; other site 1286170015736 nudix motif; other site 1286170015737 putative metal binding site [ion binding]; other site 1286170015738 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1286170015739 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1286170015740 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1286170015741 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1286170015742 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1286170015743 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1286170015744 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1286170015745 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1286170015746 dimerization interface [polypeptide binding]; other site 1286170015747 active site 1286170015748 hypothetical protein; Provisional; Region: PRK10506 1286170015749 hypothetical protein; Provisional; Region: PRK10557 1286170015750 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1286170015751 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 1286170015752 hypothetical protein; Provisional; Region: PRK10332 1286170015753 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1286170015754 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1286170015755 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1286170015756 protease3; Provisional; Region: PRK15101 1286170015757 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1286170015758 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1286170015759 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1286170015760 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1286170015761 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1286170015762 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1286170015763 AAA domain; Region: AAA_30; pfam13604 1286170015764 Family description; Region: UvrD_C_2; pfam13538 1286170015765 N-acetylglutamate synthase; Validated; Region: PRK05279 1286170015766 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1286170015767 putative feedback inhibition sensing region; other site 1286170015768 putative nucleotide binding site [chemical binding]; other site 1286170015769 putative substrate binding site [chemical binding]; other site 1286170015770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286170015771 Coenzyme A binding pocket [chemical binding]; other site 1286170015772 AMIN domain; Region: AMIN; pfam11741 1286170015773 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1286170015774 active site 1286170015775 metal binding site [ion binding]; metal-binding site 1286170015776 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 1286170015777 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170015778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170015779 homodimer interface [polypeptide binding]; other site 1286170015780 catalytic residue [active] 1286170015781 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1286170015782 cobyric acid synthase; Provisional; Region: PRK00784 1286170015783 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1286170015784 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1286170015785 catalytic triad [active] 1286170015786 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1286170015787 homotrimer interface [polypeptide binding]; other site 1286170015788 Walker A motif; other site 1286170015789 GTP binding site [chemical binding]; other site 1286170015790 Walker B motif; other site 1286170015791 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1286170015792 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1286170015793 MltA specific insert domain; Region: MltA; pfam03562 1286170015794 3D domain; Region: 3D; pfam06725 1286170015795 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1286170015796 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1286170015797 putative ATP binding site [chemical binding]; other site 1286170015798 putative substrate interface [chemical binding]; other site 1286170015799 Fe-S metabolism associated domain; Region: SufE; cl00951 1286170015800 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1286170015801 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1286170015802 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286170015803 catalytic residue [active] 1286170015804 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286170015805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170015806 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1286170015807 dimerization interface [polypeptide binding]; other site 1286170015808 substrate binding pocket [chemical binding]; other site 1286170015809 hypothetical protein; Provisional; Region: PRK10873 1286170015810 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1286170015811 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1286170015812 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1286170015813 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1286170015814 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286170015815 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1286170015816 L-fuculokinase; Provisional; Region: PRK10331 1286170015817 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286170015818 nucleotide binding site [chemical binding]; other site 1286170015819 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1286170015820 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 1286170015821 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1286170015822 trimer interface [polypeptide binding]; other site 1286170015823 substrate binding site [chemical binding]; other site 1286170015824 Mn binding site [ion binding]; other site 1286170015825 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1286170015826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015827 putative substrate translocation pore; other site 1286170015828 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1286170015829 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1286170015830 intersubunit interface [polypeptide binding]; other site 1286170015831 active site 1286170015832 Zn2+ binding site [ion binding]; other site 1286170015833 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1286170015834 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1286170015835 dimer interface [polypeptide binding]; other site 1286170015836 active site 1286170015837 metal binding site [ion binding]; metal-binding site 1286170015838 flap endonuclease-like protein; Provisional; Region: PRK09482 1286170015839 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1286170015840 active site 1286170015841 metal binding site 1 [ion binding]; metal-binding site 1286170015842 putative 5' ssDNA interaction site; other site 1286170015843 metal binding site 3; metal-binding site 1286170015844 metal binding site 2 [ion binding]; metal-binding site 1286170015845 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1286170015846 putative DNA binding site [nucleotide binding]; other site 1286170015847 putative metal binding site [ion binding]; other site 1286170015848 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1286170015849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170015850 Walker A motif; other site 1286170015851 ATP binding site [chemical binding]; other site 1286170015852 Walker B motif; other site 1286170015853 arginine finger; other site 1286170015854 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1286170015855 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1286170015856 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170015857 substrate binding pocket [chemical binding]; other site 1286170015858 membrane-bound complex binding site; other site 1286170015859 hinge residues; other site 1286170015860 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1286170015861 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1286170015862 active site 1286170015863 dimer interface [polypeptide binding]; other site 1286170015864 non-prolyl cis peptide bond; other site 1286170015865 insertion regions; other site 1286170015866 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 1286170015867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1286170015868 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1286170015869 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1286170015870 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1286170015871 active site 1286170015872 non-prolyl cis peptide bond; other site 1286170015873 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1286170015874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286170015875 Walker A/P-loop; other site 1286170015876 ATP binding site [chemical binding]; other site 1286170015877 Q-loop/lid; other site 1286170015878 ABC transporter signature motif; other site 1286170015879 Walker B; other site 1286170015880 D-loop; other site 1286170015881 H-loop/switch region; other site 1286170015882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170015883 dimer interface [polypeptide binding]; other site 1286170015884 conserved gate region; other site 1286170015885 ABC-ATPase subunit interface; other site 1286170015886 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1286170015887 benzoate transport; Region: 2A0115; TIGR00895 1286170015888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015889 putative substrate translocation pore; other site 1286170015890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015891 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1286170015892 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286170015893 active site 1286170015894 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1286170015895 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170015896 substrate binding pocket [chemical binding]; other site 1286170015897 membrane-bound complex binding site; other site 1286170015898 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1286170015899 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1286170015900 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1286170015901 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1286170015902 serine transporter; Region: stp; TIGR00814 1286170015903 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1286170015904 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1286170015905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1286170015906 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1286170015907 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1286170015908 SecY interacting protein Syd; Provisional; Region: PRK04968 1286170015909 tRNA pseudouridine synthase C; Region: DUF446; cl01187 1286170015910 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1286170015911 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1286170015912 probable active site [active] 1286170015913 flavodoxin; Provisional; Region: PRK08105 1286170015914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170015915 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170015916 putative substrate translocation pore; other site 1286170015917 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1286170015918 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1286170015919 active site 1286170015920 tetramer interface [polypeptide binding]; other site 1286170015921 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1286170015922 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1286170015923 active site 1286170015924 tetramer interface [polypeptide binding]; other site 1286170015925 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1286170015926 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1286170015927 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1286170015928 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286170015929 dimerization interface [polypeptide binding]; other site 1286170015930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286170015931 dimer interface [polypeptide binding]; other site 1286170015932 phosphorylation site [posttranslational modification] 1286170015933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286170015934 ATP binding site [chemical binding]; other site 1286170015935 Mg2+ binding site [ion binding]; other site 1286170015936 G-X-G motif; other site 1286170015937 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1286170015938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286170015939 active site 1286170015940 phosphorylation site [posttranslational modification] 1286170015941 intermolecular recognition site; other site 1286170015942 dimerization interface [polypeptide binding]; other site 1286170015943 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1286170015944 putative binding surface; other site 1286170015945 active site 1286170015946 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1286170015947 TRAM domain; Region: TRAM; pfam01938 1286170015948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170015949 S-adenosylmethionine binding site [chemical binding]; other site 1286170015950 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1286170015951 HD domain; Region: HD_4; pfam13328 1286170015952 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1286170015953 synthetase active site [active] 1286170015954 NTP binding site [chemical binding]; other site 1286170015955 metal binding site [ion binding]; metal-binding site 1286170015956 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1286170015957 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1286170015958 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1286170015959 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1286170015960 homodimer interface [polypeptide binding]; other site 1286170015961 metal binding site [ion binding]; metal-binding site 1286170015962 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1286170015963 homodimer interface [polypeptide binding]; other site 1286170015964 active site 1286170015965 putative chemical substrate binding site [chemical binding]; other site 1286170015966 metal binding site [ion binding]; metal-binding site 1286170015967 CTP synthetase; Validated; Region: pyrG; PRK05380 1286170015968 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1286170015969 Catalytic site [active] 1286170015970 active site 1286170015971 UTP binding site [chemical binding]; other site 1286170015972 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1286170015973 active site 1286170015974 putative oxyanion hole; other site 1286170015975 catalytic triad [active] 1286170015976 enolase; Provisional; Region: eno; PRK00077 1286170015977 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1286170015978 dimer interface [polypeptide binding]; other site 1286170015979 metal binding site [ion binding]; metal-binding site 1286170015980 substrate binding pocket [chemical binding]; other site 1286170015981 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286170015982 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170015983 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286170015984 putative active site [active] 1286170015985 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1286170015986 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286170015987 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170015988 active site turn [active] 1286170015989 phosphorylation site [posttranslational modification] 1286170015990 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1286170015991 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1286170015992 putative active site cavity [active] 1286170015993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170015994 NAD(P) binding site [chemical binding]; other site 1286170015995 active site 1286170015996 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1286170015997 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1286170015998 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1286170015999 active site 1286170016000 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1286170016001 Flavodoxin; Region: Flavodoxin_1; pfam00258 1286170016002 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1286170016003 FAD binding pocket [chemical binding]; other site 1286170016004 FAD binding motif [chemical binding]; other site 1286170016005 catalytic residues [active] 1286170016006 NAD binding pocket [chemical binding]; other site 1286170016007 phosphate binding motif [ion binding]; other site 1286170016008 beta-alpha-beta structure motif; other site 1286170016009 sulfite reductase subunit beta; Provisional; Region: PRK13504 1286170016010 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1286170016011 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1286170016012 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1286170016013 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1286170016014 Active Sites [active] 1286170016015 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1286170016016 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1286170016017 metal binding site [ion binding]; metal-binding site 1286170016018 siroheme synthase; Provisional; Region: cysG; PRK10637 1286170016019 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1286170016020 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1286170016021 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1286170016022 active site 1286170016023 SAM binding site [chemical binding]; other site 1286170016024 homodimer interface [polypeptide binding]; other site 1286170016025 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1286170016026 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1286170016027 Active Sites [active] 1286170016028 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1286170016029 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1286170016030 CysD dimerization site [polypeptide binding]; other site 1286170016031 G1 box; other site 1286170016032 putative GEF interaction site [polypeptide binding]; other site 1286170016033 GTP/Mg2+ binding site [chemical binding]; other site 1286170016034 Switch I region; other site 1286170016035 G2 box; other site 1286170016036 G3 box; other site 1286170016037 Switch II region; other site 1286170016038 G4 box; other site 1286170016039 G5 box; other site 1286170016040 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1286170016041 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1286170016042 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1286170016043 ligand-binding site [chemical binding]; other site 1286170016044 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1286170016045 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1286170016046 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1286170016047 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1286170016048 substrate binding site; other site 1286170016049 dimer interface; other site 1286170016050 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1286170016051 homotrimer interaction site [polypeptide binding]; other site 1286170016052 zinc binding site [ion binding]; other site 1286170016053 CDP-binding sites; other site 1286170016054 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1286170016055 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1286170016056 Permutation of conserved domain; other site 1286170016057 active site 1286170016058 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1286170016059 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1286170016060 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1286170016061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286170016062 S-adenosylmethionine binding site [chemical binding]; other site 1286170016063 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1286170016064 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286170016065 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286170016066 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1286170016067 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1286170016068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286170016069 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1286170016070 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286170016071 DNA binding residues [nucleotide binding] 1286170016072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1286170016073 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286170016074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170016075 putative substrate translocation pore; other site 1286170016076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170016077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170016078 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286170016079 putative effector binding pocket; other site 1286170016080 dimerization interface [polypeptide binding]; other site 1286170016081 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1286170016082 MutS domain I; Region: MutS_I; pfam01624 1286170016083 MutS domain II; Region: MutS_II; pfam05188 1286170016084 MutS domain III; Region: MutS_III; pfam05192 1286170016085 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1286170016086 Walker A/P-loop; other site 1286170016087 ATP binding site [chemical binding]; other site 1286170016088 Q-loop/lid; other site 1286170016089 ABC transporter signature motif; other site 1286170016090 Walker B; other site 1286170016091 D-loop; other site 1286170016092 H-loop/switch region; other site 1286170016093 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1286170016094 mobile mystery protein B; Region: mob_myst_B; TIGR02613 1286170016095 Fic/DOC family; Region: Fic; pfam02661 1286170016096 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1286170016097 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286170016098 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1286170016099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170016100 D-galactonate transporter; Region: 2A0114; TIGR00893 1286170016101 putative substrate translocation pore; other site 1286170016102 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1286170016103 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286170016104 Walker A/P-loop; other site 1286170016105 ATP binding site [chemical binding]; other site 1286170016106 Q-loop/lid; other site 1286170016107 ABC transporter signature motif; other site 1286170016108 Walker B; other site 1286170016109 D-loop; other site 1286170016110 H-loop/switch region; other site 1286170016111 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286170016112 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170016113 ABC-ATPase subunit interface; other site 1286170016114 dimer interface [polypeptide binding]; other site 1286170016115 putative PBP binding regions; other site 1286170016116 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1286170016117 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1286170016118 putative hemin binding site; other site 1286170016119 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1286170016120 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1286170016121 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1286170016122 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1286170016123 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286170016124 N-terminal plug; other site 1286170016125 ligand-binding site [chemical binding]; other site 1286170016126 Rdx family; Region: Rdx; cl01407 1286170016127 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1286170016128 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1286170016129 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170016130 ABC-ATPase subunit interface; other site 1286170016131 dimer interface [polypeptide binding]; other site 1286170016132 putative PBP binding regions; other site 1286170016133 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1286170016134 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170016135 ABC-ATPase subunit interface; other site 1286170016136 dimer interface [polypeptide binding]; other site 1286170016137 putative PBP binding regions; other site 1286170016138 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1286170016139 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1286170016140 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1286170016141 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1286170016142 metal binding site [ion binding]; metal-binding site 1286170016143 TOBE domain; Region: TOBE; cl01440 1286170016144 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1286170016145 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1286170016146 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1286170016147 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1286170016148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170016149 Walker A motif; other site 1286170016150 ATP binding site [chemical binding]; other site 1286170016151 Walker B motif; other site 1286170016152 arginine finger; other site 1286170016153 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1286170016154 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1286170016155 dimerization interface [polypeptide binding]; other site 1286170016156 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1286170016157 ATP binding site [chemical binding]; other site 1286170016158 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1286170016159 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1286170016160 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1286170016161 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1286170016162 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1286170016163 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1286170016164 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1286170016165 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1286170016166 4Fe-4S binding domain; Region: Fer4; cl02805 1286170016167 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1286170016168 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286170016169 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1286170016170 NADH dehydrogenase; Region: NADHdh; cl00469 1286170016171 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1286170016172 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1286170016173 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1286170016174 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1286170016175 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286170016176 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1286170016177 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1286170016178 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1286170016179 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1286170016180 nickel binding site [ion binding]; other site 1286170016181 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1286170016182 beta-galactosidase; Region: BGL; TIGR03356 1286170016183 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1286170016184 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286170016185 active site turn [active] 1286170016186 phosphorylation site [posttranslational modification] 1286170016187 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1286170016188 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286170016189 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286170016190 DNA binding site [nucleotide binding] 1286170016191 domain linker motif; other site 1286170016192 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1286170016193 dimerization interface (closed form) [polypeptide binding]; other site 1286170016194 ligand binding site [chemical binding]; other site 1286170016195 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1286170016196 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1286170016197 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1286170016198 Acylphosphatase; Region: Acylphosphatase; pfam00708 1286170016199 HypF finger; Region: zf-HYPF; pfam07503 1286170016200 HypF finger; Region: zf-HYPF; pfam07503 1286170016201 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1286170016202 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1286170016203 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1286170016204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286170016205 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286170016206 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1286170016207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286170016208 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1286170016209 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1286170016210 iron binding site [ion binding]; other site 1286170016211 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1286170016212 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1286170016213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170016214 Walker A motif; other site 1286170016215 ATP binding site [chemical binding]; other site 1286170016216 Walker B motif; other site 1286170016217 arginine finger; other site 1286170016218 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1286170016219 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1286170016220 putative active site [active] 1286170016221 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1286170016222 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1286170016223 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1286170016224 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286170016225 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1286170016226 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1286170016227 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1286170016228 putative NAD(P) binding site [chemical binding]; other site 1286170016229 active site 1286170016230 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1286170016231 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1286170016232 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1286170016233 Nucleoside recognition; Region: Gate; pfam07670 1286170016234 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1286170016235 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1286170016236 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1286170016237 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286170016238 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286170016239 catalytic residue [active] 1286170016240 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1286170016241 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1286170016242 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1286170016243 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286170016244 ABC-ATPase subunit interface; other site 1286170016245 dimer interface [polypeptide binding]; other site 1286170016246 putative PBP binding regions; other site 1286170016247 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1286170016248 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1286170016249 metal binding site [ion binding]; metal-binding site 1286170016250 hypothetical protein; Validated; Region: PRK03661 1286170016251 recombinase A; Provisional; Region: recA; PRK09354 1286170016252 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1286170016253 hexamer interface [polypeptide binding]; other site 1286170016254 Walker A motif; other site 1286170016255 ATP binding site [chemical binding]; other site 1286170016256 Walker B motif; other site 1286170016257 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1286170016258 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1286170016259 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1286170016260 motif 1; other site 1286170016261 active site 1286170016262 motif 2; other site 1286170016263 motif 3; other site 1286170016264 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1286170016265 DHHA1 domain; Region: DHHA1; pfam02272 1286170016266 carbon storage regulator; Provisional; Region: PRK01712 1286170016267 BON domain; Region: BON; pfam04972 1286170016268 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1286170016269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286170016270 motif II; other site 1286170016271 Predicted membrane protein [Function unknown]; Region: COG1238 1286170016272 glutamate--cysteine ligase; Provisional; Region: PRK02107 1286170016273 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1286170016274 Cupin domain; Region: Cupin_2; pfam07883 1286170016275 Helix-turn-helix domain; Region: HTH_18; pfam12833 1286170016276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170016277 2-isopropylmalate synthase; Validated; Region: PRK03739 1286170016278 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1286170016279 active site 1286170016280 catalytic residues [active] 1286170016281 metal binding site [ion binding]; metal-binding site 1286170016282 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1286170016283 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1286170016284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170016285 putative substrate translocation pore; other site 1286170016286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170016287 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1286170016288 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170016289 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170016290 transcriptional repressor MprA; Provisional; Region: PRK10870 1286170016291 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286170016292 putative L-valine exporter; Provisional; Region: PRK10408 1286170016293 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1286170016294 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1286170016295 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1286170016296 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1286170016297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170016298 dimer interface [polypeptide binding]; other site 1286170016299 conserved gate region; other site 1286170016300 putative PBP binding loops; other site 1286170016301 ABC-ATPase subunit interface; other site 1286170016302 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1286170016303 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1286170016304 Walker A/P-loop; other site 1286170016305 ATP binding site [chemical binding]; other site 1286170016306 Q-loop/lid; other site 1286170016307 ABC transporter signature motif; other site 1286170016308 Walker B; other site 1286170016309 D-loop; other site 1286170016310 H-loop/switch region; other site 1286170016311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1286170016312 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1286170016313 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1286170016314 dimer interface [polypeptide binding]; other site 1286170016315 putative radical transfer pathway; other site 1286170016316 diiron center [ion binding]; other site 1286170016317 tyrosyl radical; other site 1286170016318 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1286170016319 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1286170016320 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1286170016321 active site 1286170016322 dimer interface [polypeptide binding]; other site 1286170016323 catalytic residues [active] 1286170016324 effector binding site; other site 1286170016325 R2 peptide binding site; other site 1286170016326 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1286170016327 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1286170016328 catalytic residues [active] 1286170016329 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1286170016330 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1286170016331 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286170016332 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286170016333 DNA-binding site [nucleotide binding]; DNA binding site 1286170016334 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286170016335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286170016336 homodimer interface [polypeptide binding]; other site 1286170016337 catalytic residue [active] 1286170016338 hypothetical protein; Provisional; Region: PRK10132 1286170016339 hypothetical protein; Provisional; Region: PRK10556 1286170016340 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1286170016341 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1286170016342 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1286170016343 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1286170016344 active site residue [active] 1286170016345 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1286170016346 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286170016347 dimerization interface [polypeptide binding]; other site 1286170016348 putative DNA binding site [nucleotide binding]; other site 1286170016349 putative Zn2+ binding site [ion binding]; other site 1286170016350 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1286170016351 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170016352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170016353 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1286170016354 putative effector binding pocket; other site 1286170016355 putative dimerization interface [polypeptide binding]; other site 1286170016356 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1286170016357 active site 1286170016358 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1286170016359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170016360 Walker A motif; other site 1286170016361 ATP binding site [chemical binding]; other site 1286170016362 Walker B motif; other site 1286170016363 arginine finger; other site 1286170016364 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286170016365 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1286170016366 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286170016367 NAD(P) binding site [chemical binding]; other site 1286170016368 catalytic residues [active] 1286170016369 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1286170016370 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1286170016371 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1286170016372 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1286170016373 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1286170016374 PapC N-terminal domain; Region: PapC_N; pfam13954 1286170016375 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1286170016376 PapC C-terminal domain; Region: PapC_C; pfam13953 1286170016377 Fimbrial protein; Region: Fimbrial; pfam00419 1286170016378 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1286170016379 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170016380 Walker A/P-loop; other site 1286170016381 ATP binding site [chemical binding]; other site 1286170016382 Q-loop/lid; other site 1286170016383 ABC transporter signature motif; other site 1286170016384 Walker B; other site 1286170016385 D-loop; other site 1286170016386 H-loop/switch region; other site 1286170016387 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1286170016388 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286170016389 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286170016390 Walker A/P-loop; other site 1286170016391 ATP binding site [chemical binding]; other site 1286170016392 Q-loop/lid; other site 1286170016393 ABC transporter signature motif; other site 1286170016394 Walker B; other site 1286170016395 D-loop; other site 1286170016396 H-loop/switch region; other site 1286170016397 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286170016398 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1286170016399 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1286170016400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170016401 dimer interface [polypeptide binding]; other site 1286170016402 conserved gate region; other site 1286170016403 putative PBP binding loops; other site 1286170016404 ABC-ATPase subunit interface; other site 1286170016405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286170016406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170016407 dimer interface [polypeptide binding]; other site 1286170016408 conserved gate region; other site 1286170016409 putative PBP binding loops; other site 1286170016410 ABC-ATPase subunit interface; other site 1286170016411 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1286170016412 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286170016413 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 1286170016414 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286170016415 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286170016416 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1286170016417 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170016418 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170016419 substrate binding pocket [chemical binding]; other site 1286170016420 membrane-bound complex binding site; other site 1286170016421 hinge residues; other site 1286170016422 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170016423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170016424 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286170016425 dimerization interface [polypeptide binding]; other site 1286170016426 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1286170016427 agmatinase; Region: agmatinase; TIGR01230 1286170016428 oligomer interface [polypeptide binding]; other site 1286170016429 putative active site [active] 1286170016430 Mn binding site [ion binding]; other site 1286170016431 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170016432 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170016433 substrate binding pocket [chemical binding]; other site 1286170016434 membrane-bound complex binding site; other site 1286170016435 hinge residues; other site 1286170016436 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1286170016437 active site 1286170016438 P-loop; other site 1286170016439 phosphorylation site [posttranslational modification] 1286170016440 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1286170016441 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1286170016442 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286170016443 active site 1286170016444 phosphorylation site [posttranslational modification] 1286170016445 Helix-turn-helix domain; Region: HTH_17; cl17695 1286170016446 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286170016447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286170016448 NAD(P) binding site [chemical binding]; other site 1286170016449 active site 1286170016450 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1286170016451 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1286170016452 putative ligand binding site [chemical binding]; other site 1286170016453 NAD binding site [chemical binding]; other site 1286170016454 dimerization interface [polypeptide binding]; other site 1286170016455 catalytic site [active] 1286170016456 aldolase II superfamily protein; Provisional; Region: PRK07044 1286170016457 intersubunit interface [polypeptide binding]; other site 1286170016458 active site 1286170016459 Zn2+ binding site [ion binding]; other site 1286170016460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286170016461 dimer interface [polypeptide binding]; other site 1286170016462 conserved gate region; other site 1286170016463 ABC-ATPase subunit interface; other site 1286170016464 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286170016465 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286170016466 Walker A/P-loop; other site 1286170016467 ATP binding site [chemical binding]; other site 1286170016468 Q-loop/lid; other site 1286170016469 ABC transporter signature motif; other site 1286170016470 Walker B; other site 1286170016471 D-loop; other site 1286170016472 H-loop/switch region; other site 1286170016473 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286170016474 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286170016475 substrate binding pocket [chemical binding]; other site 1286170016476 membrane-bound complex binding site; other site 1286170016477 hinge residues; other site 1286170016478 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1286170016479 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1286170016480 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1286170016481 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1286170016482 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1286170016483 agmatinase; Region: agmatinase; TIGR01230 1286170016484 oligomer interface [polypeptide binding]; other site 1286170016485 putative active site [active] 1286170016486 Mn binding site [ion binding]; other site 1286170016487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286170016488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286170016489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286170016490 dimerization interface [polypeptide binding]; other site 1286170016491 Predicted transcriptional regulator [Transcription]; Region: COG1959 1286170016492 Transcriptional regulator; Region: Rrf2; pfam02082 1286170016493 Transcriptional regulator; Region: Rrf2; cl17282 1286170016494 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286170016495 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286170016496 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286170016497 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286170016498 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1286170016499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286170016500 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1286170016501 active site 1286170016502 homotetramer interface [polypeptide binding]; other site 1286170016503 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1286170016504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286170016505 putative substrate translocation pore; other site 1286170016506 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286170016507 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286170016508 non-specific DNA interactions [nucleotide binding]; other site 1286170016509 DNA binding site [nucleotide binding] 1286170016510 sequence specific DNA binding site [nucleotide binding]; other site 1286170016511 putative cAMP binding site [chemical binding]; other site 1286170016512 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1286170016513 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286170016514 nucleotide binding site [chemical binding]; other site 1286170016515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1286170016516 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1286170016517 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1286170016518 D5 N terminal like; Region: D5_N; smart00885 1286170016519 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1286170016520 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1286170016521 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1286170016522 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1286170016523 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 1286170016524 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1286170016525 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1286170016526 active site 1286170016527 ATP binding site [chemical binding]; other site 1286170016528 substrate binding site [chemical binding]; other site 1286170016529 activation loop (A-loop); other site 1286170016530 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 1286170016531 integrase; Provisional; Region: PRK09692 1286170016532 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1286170016533 active site 1286170016534 Int/Topo IB signature motif; other site 1286170016535 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1286170016536 SmpB-tmRNA interface; other site 1286170016537 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1286170016538 putative coenzyme Q binding site [chemical binding]; other site 1286170016539 hypothetical protein; Validated; Region: PRK01777 1286170016540 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1286170016541 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1286170016542 recombination and repair protein; Provisional; Region: PRK10869 1286170016543 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1286170016544 Walker A/P-loop; other site 1286170016545 ATP binding site [chemical binding]; other site 1286170016546 Q-loop/lid; other site 1286170016547 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1286170016548 ABC transporter signature motif; other site 1286170016549 Walker B; other site 1286170016550 D-loop; other site 1286170016551 H-loop/switch region; other site 1286170016552 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1286170016553 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1286170016554 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1286170016555 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1286170016556 dimer interface [polypeptide binding]; other site 1286170016557 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1286170016558 hypothetical protein; Provisional; Region: PRK11573 1286170016559 Domain of unknown function DUF21; Region: DUF21; pfam01595 1286170016560 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1286170016561 Transporter associated domain; Region: CorC_HlyC; smart01091 1286170016562 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1286170016563 signal recognition particle protein; Provisional; Region: PRK10867 1286170016564 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1286170016565 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1286170016566 P loop; other site 1286170016567 GTP binding site [chemical binding]; other site 1286170016568 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1286170016569 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1286170016570 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1286170016571 RimM N-terminal domain; Region: RimM; pfam01782 1286170016572 PRC-barrel domain; Region: PRC; pfam05239 1286170016573 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1286170016574 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1286170016575 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1286170016576 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1286170016577 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1286170016578 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1286170016579 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1286170016580 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1286170016581 ligand binding site [chemical binding]; other site 1286170016582 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1286170016583 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286170016584 metal binding site [ion binding]; metal-binding site 1286170016585 active site 1286170016586 I-site; other site 1286170016587 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1286170016588 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1286170016589 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1286170016590 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1286170016591 Chorismate mutase type II; Region: CM_2; cl00693 1286170016592 prephenate dehydrogenase; Validated; Region: PRK08507 1286170016593 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1286170016594 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1286170016595 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1286170016596 Prephenate dehydratase; Region: PDT; pfam00800 1286170016597 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1286170016598 putative L-Phe binding site [chemical binding]; other site 1286170016599 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1286170016600 30S subunit binding site; other site 1286170016601 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1286170016602 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1286170016603 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286170016604 RNA binding surface [nucleotide binding]; other site 1286170016605 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1286170016606 active site 1286170016607 hypothetical protein; Provisional; Region: PRK10723 1286170016608 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1286170016609 protein disaggregation chaperone; Provisional; Region: PRK10865 1286170016610 Clp amino terminal domain; Region: Clp_N; pfam02861 1286170016611 Clp amino terminal domain; Region: Clp_N; pfam02861 1286170016612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170016613 Walker A motif; other site 1286170016614 ATP binding site [chemical binding]; other site 1286170016615 Walker B motif; other site 1286170016616 arginine finger; other site 1286170016617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286170016618 Walker A motif; other site 1286170016619 ATP binding site [chemical binding]; other site 1286170016620 Walker B motif; other site 1286170016621 arginine finger; other site 1286170016622 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431