-- dump date 20140620_024025 -- class Genbank::CDS -- table cds_note -- id note YP_001623177.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate YP_001623178.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001623180.1 negatively supercoils closed circular double-stranded DNA YP_001623181.1 negatively supercoils closed circular double-stranded DNA YP_001623195.1 lipase YP_001623197.1 partial YP_001623200.1 phosphomannomutase YP_001623201.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP YP_001623202.1 partial, N-terminus YP_001623204.1 partial, C-terminus YP_001623208.1 partial, C-terminus YP_001623209.1 partial. N-terminus YP_001623224.1 partial, C-terminus YP_001623225.1 partial, N-terminus YP_001623229.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001623232.1 partial, C-terminus YP_001623233.1 partial, N-terminus YP_001623244.1 partial, N-terminus YP_001623246.1 partial, C-terminus YP_001623252.1 partial, C-terminus YP_001623253.1 partial, N-terminus YP_001623260.1 partial, C-terminus YP_001623261.1 partial, N-terminus YP_001623280.1 partial, C-terminus YP_001623281.1 partial, N-terminus YP_001623282.1 partial, N-terminus YP_001623283.1 partial YP_001623284.1 partial, C-terminus YP_001623285.1 partial YP_001623286.1 partial, C-terminus YP_001623287.1 partial YP_001623288.1 partial YP_001623295.1 iron-binding ferritin-like antioxidant protein; non-specific DNA-binding protein YP_001623300.1 OrfB YP_001623305.1 OrfA YP_001623306.1 OrfB YP_001623308.1 partial YP_001623309.1 partial YP_001623310.1 partial YP_001623311.1 partial YP_001623312.1 partial YP_001623314.1 partial YP_001623326.1 partial, C-terminus YP_001623327.1 partial, N-terminus YP_001623329.1 partial, C-terminus YP_001623330.1 partial, N-terminus YP_001623339.1 partial, C-terminus YP_001623340.1 partial, N-terminus YP_001623347.1 partial, C-terminus YP_001623348.1 partial YP_001623349.1 partial, N-terminus YP_001623350.1 converts acetoacetate to acetone and carbon dioxide YP_001623351.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001623352.1 partial, C-terminus YP_001623353.1 partial YP_001623354.1 partial, N-terminus YP_001623358.1 OrfB YP_001623359.1 OrfA YP_001623362.1 partial, C-terminus YP_001623363.1 partial, N-terminus YP_001623373.1 partial, C-terminus YP_001623374.1 partial YP_001623375.1 partial, N-terminus YP_001623387.1 partial, N-terminus YP_001623388.1 partial, C-terminus YP_001623394.1 partial, C-terminus YP_001623395.1 partial, N-terminus YP_001623398.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_001623400.1 partial, C-terminus YP_001623401.1 partial, N-terminus YP_001623403.1 partial, C-terminus YP_001623404.1 partial, N-terminus YP_001623405.1 partial, C-terminus YP_001623406.1 partial, N-terminus YP_001623407.1 partial, N-terminus YP_001623408.1 partial, C-terminus YP_001623411.1 involved in de novo purine biosynthesis YP_001623414.1 partial YP_001623415.1 Converts isocitrate to alpha ketoglutarate YP_001623418.1 partial, N-terminus YP_001623419.1 partial, C-terminus YP_001623430.1 partial YP_001623435.1 xylose repressor YP_001623438.1 partial YP_001623441.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001623445.1 partial, N-terminus YP_001623446.1 partial, C-terminus YP_001623456.1 partial, C-terminus YP_001623457.1 partial, N-terminus YP_001623470.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001623471.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001623477.1 partial YP_001623478.1 partial YP_001623479.1 partial YP_001623480.1 partial, N-terminus YP_001623481.1 partial, C-terminus YP_001623485.1 partial, N-terminus YP_001623486.1 partial, C-terminus YP_001623487.1 partial, N-terminus YP_001623488.1 partial, C-terminus YP_001623490.1 partial, N-terminus YP_001623491.1 partial, C-terminus YP_001623492.1 partial, N-terminus YP_001623493.1 partial YP_001623494.1 partial YP_001623495.1 partial, C-terminus YP_001623497.1 catalyzes the formation of inosine from adenosine YP_001623499.1 partial, N-terminus YP_001623500.1 partial, C-terminus YP_001623502.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001623521.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001623522.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_001623526.1 partial, N-terminus YP_001623527.1 partial YP_001623528.1 partial, C-terminus YP_001623530.1 partial, N-terminus YP_001623531.1 partial, C-terminus YP_001623532.1 partial, N-terminus YP_001623533.1 partial, C-terminus YP_001623538.1 OrfB YP_001623539.1 OrfA YP_001623540.1 partial, C-terminus YP_001623541.1 partial, N-terminus YP_001623542.1 partial, N-terminus YP_001623543.1 partial, C-terminus YP_001623547.1 partial YP_001623559.1 OrfB YP_001623560.1 OrfB YP_001623561.1 OrfA YP_001623565.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001623568.1 partial, N-terminus YP_001623569.1 partial, C-terminus YP_001623572.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_001623579.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001623584.1 OrfA YP_001623585.1 OrfB YP_001623586.1 OrfB YP_001623589.1 partial, N-terminus YP_001623590.1 partial, C-terminus YP_001623594.1 partial, N-terminus' YP_001623595.1 partial, C-terminus' YP_001623596.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001623599.1 OrfA YP_001623600.1 OrfB YP_001623602.1 partial, N-terminus YP_001623603.1 partial, C-terminus YP_001623604.1 partial, N-terminus YP_001623605.1 partial, C-terminus YP_001623617.1 partial, C-terminus YP_001623618.1 partial, N-terminus YP_001623622.1 partial YP_001623646.2 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001623651.1 partial, C-terminus YP_001623652.1 partial YP_001623653.1 partial, N-terminus YP_001623655.1 partial YP_001623660.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate YP_001623661.1 partial, N-terminus YP_001623667.1 partial, N-terminus YP_001623668.1 partial YP_001623669.1 partial, C-terminus' YP_001623671.1 partial, C-terminus YP_001623672.1 partial YP_001623673.1 partial, N-terminus YP_001623674.1 partial, C-terminus YP_001623675.1 partial, N-terminus YP_001623683.1 partial YP_001623690.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001623691.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001623694.1 Catalyzes the phosphorylation of UMP to UDP YP_001623695.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001623698.1 partial, C-terminus YP_001623699.1 partial, N-terminus YP_001623720.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine YP_001623723.1 partial, N-terminus YP_001623724.1 partial, C-terminus YP_001623728.1 OrfB YP_001623729.1 OrfA YP_001623736.1 partial, N-terminus YP_001623737.1 partial, C-terminus YP_001623741.1 OrfB YP_001623742.1 OrfA YP_001623747.1 partial, C-terminus YP_001623748.1 partial YP_001623749.1 partial YP_001623750.1 partial, N-terminus YP_001623751.1 partial, C-terminus YP_001623752.1 partial, N-terminus YP_001623753.1 partial YP_001623754.1 OrfA YP_001623755.1 OrfB YP_001623756.1 partial YP_001623758.1 partial, C-terminus YP_001623759.1 partial, N-terminus YP_001623770.1 partial, C-terminus YP_001623771.1 partial, N-terminus YP_001623773.1 partial YP_001623778.1 OrfB YP_001623779.1 OrfA YP_001623780.1 partial, N-terminus YP_001623781.1 partial, C-terminus YP_001623790.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001623792.1 OrfB YP_001623793.1 OrfA YP_001623796.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001623802.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001623805.1 partial, C-terminus YP_001623806.1 partial, N-terminus YP_001623809.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001623817.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001623820.1 partial, N-terminus YP_001623821.1 partial, C-terminus YP_001623826.1 OrfA YP_001623827.1 OrfB YP_001623829.1 riboflavin kinase YP_001623835.1 OrfB YP_001623836.1 OrfA YP_001623839.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001623852.1 partial, C-terminus YP_001623853.1 partial, N-terminus YP_001623858.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001623862.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001623870.1 partial, N-terminus YP_001623871.1 partial, C-terminus YP_001623874.1 partial, C-terminus YP_001623875.1 partial, N-terminus YP_001623877.1 partial YP_001623883.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001623884.1 partial, N-terminus YP_001623885.1 partial, C-terminus YP_001623887.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001623889.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001623891.1 partial YP_001623894.1 Represses a number of genes involved in the response to DNA damage YP_001623896.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001623897.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_001623898.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001623900.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis YP_001623914.1 partial, C-terminus YP_001623915.1 partial, N-terminus YP_001623916.1 partial YP_001623917.1 OrfA YP_001623918.1 OrfB YP_001623921.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001623922.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001623924.1 partial, C-terminus YP_001623925.1 partial, N-terminus YP_001623929.1 partial, C-terminus YP_001623930.1 partial, N-terminus YP_001623931.1 partial, C-terminus YP_001623932.1 partial YP_001623933.1 partial, N-terminus YP_001623934.1 partial, C-terminus YP_001623935.1 partial, N-terminus YP_001623938.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001623939.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_001623940.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001623941.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_001623942.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_001623943.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_001623944.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_001623945.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001623948.1 partial, N-terminus YP_001623949.1 partial, C-terminus YP_001623951.1 partial, C-terminus YP_001623952.1 partial, N-terminus YP_001623961.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001623969.1 hemolysin A YP_001623970.1 catalyzes the phosphorylation of NAD to NADP YP_001623972.1 partial YP_001623973.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001623982.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate YP_001623984.1 2-methylisocitrate dehydratase YP_001623987.1 partial YP_001623990.1 partial, N-terminus YP_001623991.1 partial, C-terminus YP_001623992.1 4-Hydroxy-2-oxoglutarate aldolase YP_001623993.1 partial, N-terminus YP_001623994.1 partial, C-terminus YP_001623995.1 partial YP_001623996.1 OrfA YP_001623997.1 OrfB YP_001624005.1 partial, N-terminus YP_001624006.1 partial YP_001624007.1 partial, C-terminus YP_001624015.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_001624018.1 partial YP_001624019.1 partial YP_001624022.1 partial YP_001624025.1 partial, N-terminus YP_001624026.1 partial, C-terminus YP_001624035.1 partial, C-terminus YP_001624036.1 partial, N-terminus YP_001624044.1 partial YP_001624048.1 partial, C-terminus YP_001624049.1 partial, N-terminus YP_001624054.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_001624065.1 partial YP_001624067.1 partial, N-terminus YP_001624068.1 partial YP_001624069.1 partial, C-terminus YP_001624070.1 partial, N-terminus YP_001624071.1 partial, C-terminus YP_001624075.1 partial YP_001624076.1 phenazine biosynthesis fusion protein YP_001624077.1 partial YP_001624078.1 partial YP_001624083.1 partial, N-terminus YP_001624084.1 partial, C-terminus YP_001624086.1 partial, N-terminus YP_001624087.1 partial, C-terminus YP_001624089.1 partial YP_001624101.1 partial, C-terminus YP_001624102.1 partial, N-terminus YP_001624105.1 OrfB YP_001624106.1 OrfA YP_001624111.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001624120.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_001624122.1 partial, C-terminus YP_001624123.1 partial, C-terminus YP_001624136.1 OrfA YP_001624138.1 OrfB YP_001624139.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_001624140.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001624142.1 binds directly to 23S ribosomal RNA YP_001624143.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001624146.1 partial YP_001624147.1 partial YP_001624148.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001624150.1 partial YP_001624152.1 partial YP_001624153.1 OrfB YP_001624154.1 OrfA YP_001624164.1 partial, C-terminus YP_001624165.1 partial, N-terminus YP_001624173.1 partial, N-terminus YP_001624174.1 partial, C-terminus YP_001624176.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_001624177.1 partial, C-terminus YP_001624178.1 partial, N-terminus YP_001624181.1 OrfB YP_001624182.1 OrfB YP_001624183.1 OrfA YP_001624192.1 partial YP_001624194.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001624195.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate YP_001624196.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_001624197.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001624198.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001624199.1 partial, N-terminus YP_001624200.1 partial YP_001624201.1 partial, C-terminus YP_001624206.1 partial, C-terminus YP_001624207.1 partial, N-terminus YP_001624208.1 partial, C-terminus YP_001624209.1 partial, N-terminus YP_001624210.1 partial, C-terminus YP_001624211.1 partial, N-terminus YP_001624212.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001624215.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001624219.1 OrfA YP_001624220.1 OrfB YP_001624222.1 partial, N-terminus YP_001624223.1 partial, C-terminus YP_001624225.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001624230.1 partial YP_001624235.1 Essential for efficient processing of 16S rRNA YP_001624236.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001624237.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001624240.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001624245.1 OrfB YP_001624246.1 OrfA YP_001624247.1 partial, C-terminus YP_001624252.1 carries the fatty acid chain in fatty acid biosynthesis YP_001624253.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001624258.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_001624262.1 partial YP_001624264.1 partial YP_001624265.1 partial YP_001624266.1 partial YP_001624267.1 partial YP_001624269.1 partial, C-terminus YP_001624270.1 partial, N-terminus YP_001624273.1 OrfA YP_001624274.1 OrfB YP_001624278.1 partial YP_001624280.1 partial, N-terminus YP_001624281.1 partial, C-terminus YP_001624289.1 partial, C-terminus; trans-enoyl-CoA reductase YP_001624290.1 partial, N-terminus; trans-enoyl-CoA reductase YP_001624294.1 partial, N-terminus YP_001624295.1 partial, C-terminus YP_001624301.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_001624302.1 OrfA YP_001624303.1 OrfB YP_001624308.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001624310.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001624311.1 partial, N-terminus YP_001624312.1 partial, C-terminus YP_001624323.1 partial, N-terminus YP_001624324.1 partial, C-terminus YP_001624325.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_001624327.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis YP_001624333.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate YP_001624358.1 partial, N-terminus YP_001624359.1 partial, C-terminus YP_001624360.1 partial, N-terminus YP_001624361.1 partial, C-terminus YP_001624363.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_001624370.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001624371.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001624374.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001624375.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001624377.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001624379.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001624384.1 3'-5' exonuclease of DNA polymerase III YP_001624396.1 partial, C-terminus YP_001624397.1 partial, N-terminus YP_001624410.1 partial, C-terminus YP_001624411.1 partial YP_001624412.1 partial, N-terminus YP_001624422.1 OrfB YP_001624423.1 OrfA YP_001624424.1 partial YP_001624427.1 partial, N-terminus YP_001624428.1 partial, C-terminus YP_001624429.1 partial, N-terminus YP_001624430.1 partial, C-terminus YP_001624433.1 partial, N-terminus YP_001624434.1 partial, C-terminus YP_001624439.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_001624440.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001624441.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001624443.1 partial, C-terminus YP_001624444.1 partial, N-terminus YP_001624446.1 OrfB YP_001624447.1 OrfA YP_001624448.1 partial, C-terminus YP_001624449.1 partial, N-terminus YP_001624450.1 partial, C-terminus YP_001624452.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_001624453.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_001624454.1 partial, N-terminus YP_001624455.1 partial, C-terminus YP_001624468.1 partial, N-terminus YP_001624469.1 partial, C-terminus YP_001624472.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_001624473.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_001624474.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_001624476.1 catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_001624477.1 partial, C-terminus YP_001624478.1 partial YP_001624479.1 partial YP_001624480.1 partial, N-terminus YP_001624482.1 xylose repressor YP_001624486.1 partial YP_001624487.1 OrfB YP_001624488.1 OrfA YP_001624494.1 OrfB YP_001624495.1 OrfA YP_001624496.1 partial, C-terminus YP_001624497.1 partial, N-terminus YP_001624498.1 type II secretion system protein E YP_001624500.1 type II secretion system protein YP_001624501.1 partial, N-terminus YP_001624502.1 partial, C-terminus YP_001624511.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001624520.1 OrfA YP_001624521.1 OrfB YP_001624529.1 partial, C-terminus; selenocysteine lyase YP_001624530.1 partial, N-terminus; selenocysteine lyase YP_001624533.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001624542.1 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth YP_001624545.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001624553.1 partial, N-terminus YP_001624554.1 partial, C-terminus YP_001624557.1 partial, N-terminus YP_001624558.1 partial YP_001624562.1 partial YP_001624573.1 partial, N-terminus YP_001624574.1 partial YP_001624575.1 partial, C-terminus YP_001624576.1 partial YP_001624577.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001624579.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_001624580.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001624582.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001624583.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001624588.1 UDP-N-acetylglucosamine 4,6-dehydratase YP_001624592.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001624596.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001624597.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001624598.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001624610.1 partial, N-terminus YP_001624611.1 partial YP_001624612.1 partial, C-terminus YP_001624613.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_001624617.1 pyrazinamidase YP_001624621.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_001624623.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001624626.1 partial, C-terminus YP_001624627.1 partial, N-terminus YP_001624635.1 partial, C-terminus YP_001624636.1 partial, N-terminus YP_001624638.1 OrfA YP_001624639.1 OrfB YP_001624647.1 partial, N-terminus YP_001624648.1 partial, C-terminus YP_001624652.1 partial, C-terminus YP_001624653.1 partial, N-terminus YP_001624664.1 partial, N-terminus YP_001624665.1 partial, C-terminus YP_001624667.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_001624668.1 partial, N-terminus YP_001624669.1 partial, C-terminus YP_001624671.1 selenocysteine lyase YP_001624673.1 partial, N-terminus YP_001624674.1 partial, C-terminus YP_001624689.1 OrfA YP_001624690.1 OrfB YP_001624691.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001624693.1 partial, N-terminus YP_001624696.1 partial, N-terminus YP_001624697.1 partial YP_001624698.1 partial, C-terminus YP_001624701.1 partial, C-terminus YP_001624702.1 partial, N-terminus YP_001624703.1 partial, N-terminus YP_001624704.1 partial, C-terminus YP_001624705.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA YP_001624707.1 partial, C-terminus YP_001624708.1 partial, N-terminus YP_001624712.1 partial, N-terminus YP_001624713.1 partial, C-terminus YP_001624716.1 partial, N-terminus YP_001624717.1 partial, C-terminus YP_001624725.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001624738.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001624742.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_001624745.1 OrfA YP_001624748.1 partial, C-terminus YP_001624749.1 partial, N-terminus YP_001624750.1 partial, C-terminus; O-acetyl-L-serine sulfhydrolase YP_001624751.1 partial, N-terminus; O-acetyl-L-serine sulfhydrolase YP_001624757.1 OrfA YP_001624758.1 OrfB YP_001624779.1 OrfA YP_001624780.1 OrfB YP_001624781.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001624783.1 OrfB YP_001624784.1 OrfA YP_001624786.1 partial, C-terminus YP_001624787.1 partial, N-terminus YP_001624800.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001624807.1 partial, N-terminus YP_001624808.1 partial, C-terminus YP_001624809.1 partial, C-terminus YP_001624810.1 partial, N-terminus YP_001624811.1 partial, C-terminus YP_001624812.1 partial, N-terminus YP_001624813.1 partial, C-terminus YP_001624814.1 partial YP_001624815.1 OrfA YP_001624816.1 OrfB YP_001624817.1 partial, N-terminus YP_001624818.1 partial, C-terminus YP_001624819.1 partial YP_001624820.1 partial YP_001624821.1 partial, N-terminus YP_001624823.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001624824.1 selenocysteine lyase YP_001624829.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_001624837.1 partial, N-terminus YP_001624838.1 partial, C-terminus YP_001624844.1 partial, N-terminus YP_001624845.1 partial, C-terminus YP_001624846.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001624854.1 partial, C-terminus YP_001624855.1 partial, N-terminus YP_001624856.1 partial, C-terminus YP_001624857.1 partial, N-terminus YP_001624860.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_001624861.1 OrfB YP_001624862.1 OrfA YP_001624866.1 partial, C-terminus YP_001624867.1 partial, N-terminus YP_001624871.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_001624872.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001624878.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001624881.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001624882.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_001624885.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001624886.1 forms a direct contact with the tRNA during translation YP_001624887.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001624891.1 OrfA YP_001624892.1 OrfB YP_001624904.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001624910.1 partial, C-terminus YP_001624911.1 partial YP_001624912.1 partial, N-terminus YP_001624913.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001624917.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth YP_001624920.1 OrfB YP_001624921.1 OrfA YP_001624923.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001624925.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001624927.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001624931.1 RecG YP_001624937.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001624939.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001624944.1 OrfB YP_001624945.1 OrfA YP_001624946.1 partial, C-terminus YP_001624950.1 methylmalonate-semialdehyde dehydrogenase (acylating) YP_001624953.1 partial, N-terminus YP_001624954.1 partial, C-terminus YP_001624956.1 partial, N-terminus YP_001624957.1 partial, C-terminus YP_001624960.1 partial, N-terminus YP_001624961.1 partial, C-terminus YP_001624962.1 partial, C-terminus YP_001624963.1 partial, N-terminus YP_001624973.1 partial, C-terminus YP_001624974.1 partial, N-terminus YP_001624983.1 OrfA YP_001624987.1 partial, C-terminus YP_001624988.1 partial, N-terminus YP_001624992.1 partial, N-terminus YP_001624993.1 partial, C-terminus YP_001624997.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA YP_001624998.1 methylmalonate-semialdehyde dehydrogenase (acylating) YP_001624999.1 partial, C-terminus YP_001625000.1 partial, N-terminus YP_001625001.1 partial, C-terminus YP_001625002.1 partial, N-terminus YP_001625005.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001625009.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001625010.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001625025.1 partial YP_001625056.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001625057.1 partial YP_001625059.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_001625061.1 OrfB YP_001625062.1 OrfA YP_001625066.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001625069.1 partial, C-terminus YP_001625070.1 partial, N-terminus YP_001625072.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001625077.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001625078.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001625080.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001625081.1 partial, C-terminus YP_001625082.1 partial, N-terminus YP_001625087.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001625091.1 partial, N-terminus YP_001625092.1 partial, C-terminus YP_001625103.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001625104.1 phosphopantothenoylcysteine decarboxylase YP_001625106.1 Essential for recycling GMP and indirectly, cGMP YP_001625110.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001625111.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001625113.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001625114.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001625115.1 uracil phosphoribosyltransferase YP_001625118.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001625120.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001625122.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001625126.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001625129.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001625136.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001625137.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001625142.1 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase YP_001625143.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001625144.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001625146.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001625147.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001625148.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001625150.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_001625156.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_001625159.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001625164.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001625191.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001625192.1 phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001625195.1 partial, C-terminus YP_001625196.1 partial YP_001625197.1 partial, N-terminus YP_001625210.1 hypothetical membrane protein YP_001625217.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001625218.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001625230.1 partial, C-terminus YP_001625231.1 partial, N-terminus YP_001625237.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001625254.1 similar to cobalt permease or related transporter YP_001625259.1 OrfA YP_001625260.1 OrfB YP_001625263.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001625264.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001625265.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001625266.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_001625267.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001625271.1 partial, N-terminus YP_001625272.1 partial, C-terminus YP_001625279.1 partial, C-terminus YP_001625280.1 partial, N-terminus; thiolase YP_001625282.1 OrfB YP_001625283.1 OrfA YP_001625285.1 partial YP_001625286.1 partial, C-terminus YP_001625287.1 partial, N-terminus YP_001625289.1 nucleoside-diphosphate kinase YP_001625290.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001625292.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001625295.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001625296.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001625297.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001625298.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001625299.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001625300.1 partial, C-terminus YP_001625301.1 partial, N-terminus YP_001625304.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001625306.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001625307.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001625308.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001625309.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001625311.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001625314.1 partial, N-terminus YP_001625315.1 partial, C-terminus YP_001625317.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001625318.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001625319.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001625320.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001625321.1 partial, C-terminus YP_001625322.1 partial, N-terminus YP_001625323.1 partial, N-terminus YP_001625324.1 partial, C-terminus YP_001625326.1 partial, N-terminus YP_001625327.1 partial, C-terminus YP_001625331.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001625332.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001625342.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_001625345.1 OrfA YP_001625346.1 OrfB YP_001625353.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_001625354.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_001625356.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001625357.1 partial, N-terminus YP_001625358.1 partial, C-terminus YP_001625360.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001625371.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001625372.1 partial, N-terminus YP_001625373.1 partial, C-terminus YP_001625377.1 partial YP_001625378.1 OrfA YP_001625379.1 OrfB YP_001625390.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001625391.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001625392.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate YP_001625394.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001625408.1 partial, C-terminus YP_001625409.1 partial, N-terminus YP_001625415.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001625421.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001625424.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001625430.1 beta-lactamase domain protein YP_001625435.1 partial YP_001625437.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001625441.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain YP_001625444.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001625449.1 partial, C-terminus YP_001625450.1 partial, N-terminus YP_001625456.1 OrfA YP_001625457.1 OrfB YP_001625460.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_001625463.1 partial, C-terminus YP_001625464.1 partial, N-terminus YP_001625466.1 partial, C-terminus YP_001625467.1 partial, N-terminus YP_001625472.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_001625473.1 partial, C-terminus YP_001625474.1 partial, N-terminus YP_001625476.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001625477.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001625478.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_001625485.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001625486.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_001625488.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001625491.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001625505.1 partial YP_001625509.1 partial, N-terminus YP_001625510.1 partial, C-terminus YP_001625523.1 hrdc:3'-5' exonuclease YP_001625525.1 delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase; enoyl-CoA hydratase YP_001625529.1 partial, C-terminus YP_001625530.1 partial, N-terminus YP_001625532.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001625540.1 partial; OrfA YP_001625549.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_001625552.1 partial YP_001625553.1 acetyltransferase (GNAT) family protein YP_001625554.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001625563.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001625571.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001625582.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_001625583.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001625588.1 OrfA YP_001625589.1 OrfB YP_001625594.1 partial, C-terminus YP_001625595.1 partial, N-terminus YP_001625602.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_001625604.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001625606.1 OrfA YP_001625607.1 OrfB YP_001625612.1 partial, N-terminus YP_001625613.1 partial, C-terminus YP_001625614.1 polyphosphate glucokinase; transcriptional regulator YP_001625619.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001625621.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001625625.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001625633.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001625634.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001625637.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001625640.1 division specific D,D-transpeptidase YP_001625643.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001625644.1 partial, C-terminus YP_001625645.1 partial, N-terminus YP_001625649.1 geranylgeranyl pyrophosphate synthetase; geranyltranstransferase YP_001625658.1 xylose repressor YP_001625662.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_001625674.1 partial, C-terminus YP_001625675.1 partial, N-terminus YP_001625676.1 partial, C-terminus YP_001625677.1 partial, N-terminus YP_001625688.1 partial, N-terminus YP_001625689.1 partial, C-terminus YP_001625697.1 partial, N-terminus YP_001625698.1 partial YP_001625699.1 partial, C-terminus YP_001625701.1 OrfA YP_001625702.1 OrfB YP_001625720.1 partial, C-terminus YP_001625721.1 partial, N-terminus YP_001625727.1 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001625730.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate YP_001625738.1 OrfA YP_001625739.1 OrfB YP_001625743.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_001625747.1 partial, C-terminus YP_001625748.1 partial, N-terminus; sirohydrochlorin ferrochelatase; uroporphyrin-III C-methyltransferase YP_001625749.1 partial YP_001625750.1 partial, C-terminus YP_001625751.1 partial, N-terminus YP_001625755.1 partial, C-terminus YP_001625756.1 partial, N-terminus YP_001625757.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_001625758.1 partial, C-terminus YP_001625759.1 partial, N-terminus YP_001625761.1 partial, N-terminus YP_001625762.1 OrfB YP_001625763.1 OrfA YP_001625764.1 partial, C-terminus YP_001625765.1 partial, C-terminus YP_001625766.1 partial, N-terminus YP_001625774.1 farnesyltransferase; geranyltranstransferase; solanesyl diphosphate synthase YP_001625775.1 partial, C-terminus YP_001625776.1 partial, N-terminus YP_001625782.1 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase YP_001625800.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation YP_001625801.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA YP_001625802.1 partial YP_001625803.1 partial YP_001625804.1 partial YP_001625805.1 partial YP_001625812.1 phenylacetate-coenzyme A ligase YP_001625819.1 partial, C-terminus YP_001625820.1 partial YP_001625821.1 partial, N-terminus YP_001625832.1 partial, C-terminus YP_001625833.1 partial, N-terminus YP_001625836.1 partial, N-terminus YP_001625838.1 partial, C-terminus YP_001625841.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_001625844.1 heme export protein YP_001625852.1 modulates transcription in response to the NADH/NAD(+) redox state YP_001625869.1 partial, N-terminus YP_001625870.1 partial, C-terminus YP_001625874.1 partial, C-terminus YP_001625875.1 partial, N-terminus YP_001625880.1 partial, N-terminus YP_001625881.1 partial, C-terminus YP_001625886.1 partial, N-terminus YP_001625887.1 partial, C-terminus YP_001625893.1 partial, C-terminus YP_001625894.1 partial, N-terminus YP_001625896.1 partial, N-terminus YP_001625897.1 partial, C-terminus YP_001625901.1 OrfB YP_001625902.1 OrfA YP_001625904.1 partial, N-terminus YP_001625905.1 partial YP_001625906.1 partial YP_001625907.1 partial, C-terminus YP_001625914.1 partial, N-terminus YP_001625915.1 partial, C-terminus YP_001625918.1 partial, N-terminus; xylose repressor YP_001625919.1 partial, C-terminus; xylose repressor YP_001625923.1 partial, N-terminus YP_001625924.1 partial, C-terminus YP_001625928.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001625938.1 OrfB YP_001625939.1 OrfA YP_001625947.1 partial, N-terminus YP_001625948.1 partial, C-terminus YP_001625949.1 partial, N-terminus YP_001625950.1 partial, C-terminus YP_001625952.1 OrfA YP_001625953.1 OrfB YP_001625954.1 partial, C-terminus YP_001625955.1 partial, N-terminus YP_001625963.1 partial, N-terminus YP_001625964.1 partial, C-terminus YP_001625967.1 OrfA YP_001625968.1 OrfB YP_001625972.1 partial, N-terminus YP_001625974.1 partial, C-terminus YP_001625979.1 partial, C-terminus YP_001625980.1 partial, N-terminus YP_001625981.1 partial YP_001625982.1 partial, C-terminus YP_001625983.1 partial, N-terminus YP_001625985.1 partial, N-terminus YP_001625986.1 partial, C-terminus YP_001625994.1 partial, C-terminus YP_001625995.1 partial, N-terminus YP_001625996.1 partial, N-terminus YP_001625997.1 partial YP_001625998.1 partial YP_001625999.1 partial, C-terminus YP_001626007.1 partial, C-terminus YP_001626008.1 partial, N-terminus YP_001626013.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001626014.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001626016.1 OrfA YP_001626017.1 OrfB YP_001626031.1 para-aminobenzoate synthase glutamine amidotransferase component II YP_001626036.1 partial, N-terminus YP_001626037.1 partial YP_001626038.1 partial, C-terminus YP_001626040.1 OrfA YP_001626041.1 OrfB YP_001626042.1 synthesizes RNA primers at the replication forks YP_001626045.1 partial, C-terminus YP_001626046.1 partial, N-terminus YP_001626047.1 partial, C-terminus YP_001626048.1 partial, N-terminus YP_001626058.1 partial, N-terminus YP_001626059.1 partial, C-terminus YP_001626060.1 partial, N-terminus YP_001626061.1 partial, C-terminus YP_001626062.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_001626066.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001626070.1 partial, C-terminus YP_001626071.1 partial, N-terminus YP_001626074.1 partial, C-terminus YP_001626075.1 partial, N-terminus YP_001626079.1 OrfA YP_001626080.1 OrfB YP_001626086.1 biotin--[acetyl-CoA-carboxylase] synthetase YP_001626093.1 propionyl-CoA carboxylase biotin-containing subunit YP_001626095.1 partial, C-terminus YP_001626096.1 partial, N-terminus YP_001626099.1 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity YP_001626100.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_001626101.1 phosphomannomutase YP_001626102.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001626105.1 partial, N-terminus YP_001626106.1 partial, C-terminus YP_001626112.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_001626119.1 selenocysteine lyase YP_001626121.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001626123.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001626124.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001626125.1 partial, N-terminus YP_001626126.1 partial, C-terminus YP_001626128.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis YP_001626129.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001626132.1 partial, N-terminus YP_001626133.1 partial, C-terminus YP_001626139.1 partial, N-terminus YP_001626140.1 partial YP_001626141.1 partial, C-terminus YP_001626146.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_001626163.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_001626167.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001626170.1 partial YP_001626171.1 partial YP_001626187.1 catalyzes the formation of 2-oxobutanoate from L-threonine YP_001626195.1 partial, C-terminus YP_001626196.1 partial, N-terminus YP_001626199.1 OrfA YP_001626201.1 partial, C-terminus YP_001626202.1 partial, N-terminus YP_001626205.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001626212.1 partial, C-terminus YP_001626213.1 partial, N-terminus YP_001626217.1 partial, N-terminus YP_001626218.1 partial, C-terminus YP_001626219.1 partial, N-terminus YP_001626220.1 partial YP_001626221.1 partial, C-terminus YP_001626228.1 partial, C-terminus YP_001626229.1 partial YP_001626230.1 partial YP_001626231.1 partial, N-terminus YP_001626244.1 partial, C-terminus YP_001626245.1 partial, N-terminus YP_001626246.1 partial, C-terminus YP_001626247.1 partial, N-terminus YP_001626251.1 OrfB YP_001626252.1 OrfA YP_001626257.1 partial, C-terminus YP_001626258.1 partial YP_001626259.1 partial, N-terminus YP_001626261.1 partial, C-terminus YP_001626262.1 partial, N-terminus YP_001626267.1 partial, N-terminus YP_001626268.1 partial, C-terminus YP_001626274.1 partial, N-terminus YP_001626275.1 partial, C-terminus YP_001626276.1 partial, N-terminus YP_001626277.1 partial, C-terminus YP_001626280.1 partial, N-terminus YP_001626281.1 partial YP_001626282.1 partial, C-terminus YP_001626300.1 metalloprotease YP_001626304.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001626309.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001626310.1 non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair YP_001626315.1 partial, C-terminus YP_001626316.1 partial, N-terminus YP_001626320.1 catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis YP_001626321.1 partial, C-terminus YP_001626322.1 partial YP_001626323.1 partial, N-terminus YP_001626326.1 negative regulator of genetic competence YP_001626329.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001626334.1 partial, N-terminus YP_001626335.1 partial, C-terminus YP_001626337.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001626356.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001626362.1 OrfB YP_001626363.1 OrfA YP_001626367.1 partial, C-terminus YP_001626368.1 partial, N-terminus YP_001626373.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_001626375.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001626376.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001626377.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001626378.1 involved in the peptidyltransferase reaction during translation YP_001626381.1 phosphomethylpyrimidine kinase YP_001626387.1 folylpolyglutamate synthase YP_001626388.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) YP_001626391.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001626392.1 partial YP_001626396.1 binds and unfolds substrates as part of the ClpXP protease YP_001626397.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001626399.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001626403.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_001626412.1 has some similarity with cytochrome p450 YP_001626415.1 partial, C-terminus YP_001626416.1 partial, N-terminus YP_001626423.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001626426.1 partial, C-terminus YP_001626427.1 partial, N-terminus YP_001626433.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_001626437.1 partial, C-terminus YP_001626438.1 partial, N-terminus YP_001626443.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent YP_001626457.1 OrfA YP_001626458.1 OrfB YP_001626460.1 OrfB YP_001626461.1 OrfA YP_001626464.1 partial, N-terminus YP_001626465.1 partial YP_001626466.1 partial, C-terminus YP_001626474.1 partial, C-terminus YP_001626475.1 partial, N-terminus YP_001626477.1 partial, N-terminus YP_001626478.1 partial, C-terminus YP_001626480.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_001626481.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001626482.1 partial, C-terminus YP_001626483.1 partial, N-terminus YP_001626484.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_001626488.1 partial, N-terminus YP_001626489.1 partial YP_001626490.1 partial, C-terminus YP_001626494.1 partial, C-terminus YP_001626495.1 partial, N-terminus YP_001626500.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001626508.1 OrfB YP_001626509.1 OrfA YP_001626514.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001626518.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_001626519.1 partial, C-terminus YP_001626520.1 partial, N-terminus YP_001626521.1 OrfB YP_001626522.1 OrfA YP_001626527.1 partial, C-terminus YP_001626528.1 partial YP_001626529.1 partial, N-terminus YP_001626530.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001626544.1 partial, C-terminus YP_001626545.1 partial YP_001626548.1 two-component response regulator YP_001626551.1 partial, C-terminus YP_001626552.1 partial, N-terminus YP_001626556.1 OrfA YP_001626557.1 OrfB YP_001626563.1 3-hydroxybutyryl-CoA epimerase; delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase; enoyl-CoA hydratase YP_001626564.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001626569.1 OrfB YP_001626570.1 OrfA YP_001626572.1 partial, C-terminus YP_001626573.1 partial, N-terminus YP_001626574.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_001626575.1 partial, N-terminus YP_001626586.1 partial, N-terminus YP_001626587.1 partial, C-terminus YP_001626592.1 partial YP_001626597.1 OrfA YP_001626598.1 OrfB YP_001626606.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001626607.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_001626610.1 partial YP_001626616.1 OrfB YP_001626617.1 OrfA YP_001626618.1 partial, C-terminus YP_001626626.1 partial, N-terminus YP_001626627.1 partial, C-terminus YP_001626647.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001626648.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001626650.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001626654.1 partial, N-terminus YP_001626655.1 partial, C-terminus YP_001626658.1 OrfB YP_001626659.1 OrfA YP_001626660.1 partial, N-terminus YP_001626661.1 partial, C-terminus YP_001626676.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA