-- dump date 20140620_024025 -- class Genbank::misc_feature -- table misc_feature_note -- id note 288705000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 288705000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705000003 Walker A motif; other site 288705000004 ATP binding site [chemical binding]; other site 288705000005 Walker B motif; other site 288705000006 arginine finger; other site 288705000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 288705000008 DnaA box-binding interface [nucleotide binding]; other site 288705000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 288705000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 288705000011 putative DNA binding surface [nucleotide binding]; other site 288705000012 dimer interface [polypeptide binding]; other site 288705000013 beta-clamp/clamp loader binding surface; other site 288705000014 beta-clamp/translesion DNA polymerase binding surface; other site 288705000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 288705000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 288705000017 recombination protein F; Reviewed; Region: recF; PRK00064 288705000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705000019 Walker A/P-loop; other site 288705000020 ATP binding site [chemical binding]; other site 288705000021 Q-loop/lid; other site 288705000022 ABC transporter signature motif; other site 288705000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705000024 ABC transporter signature motif; other site 288705000025 Walker B; other site 288705000026 D-loop; other site 288705000027 H-loop/switch region; other site 288705000028 Protein of unknown function (DUF721); Region: DUF721; cl02324 288705000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 288705000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 288705000031 anchoring element; other site 288705000032 dimer interface [polypeptide binding]; other site 288705000033 ATP binding site [chemical binding]; other site 288705000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 288705000035 active site 288705000036 putative metal-binding site [ion binding]; other site 288705000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 288705000038 DNA gyrase subunit A; Validated; Region: PRK05560 288705000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 288705000040 CAP-like domain; other site 288705000041 active site 288705000042 primary dimer interface [polypeptide binding]; other site 288705000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288705000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288705000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288705000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288705000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288705000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288705000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 288705000050 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 288705000051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 288705000052 active site 288705000053 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288705000054 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 288705000055 active site 288705000056 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 288705000057 Zn2+ binding site [ion binding]; other site 288705000058 Rhomboid family; Region: Rhomboid; pfam01694 288705000059 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288705000060 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 288705000061 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 288705000062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705000063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705000064 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 288705000065 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 288705000066 dimer interface [polypeptide binding]; other site 288705000067 active site 288705000068 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288705000069 substrate binding site [chemical binding]; other site 288705000070 catalytic residue [active] 288705000071 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 288705000072 FAD binding domain; Region: FAD_binding_4; pfam01565 288705000073 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 288705000074 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 288705000075 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 288705000076 substrate binding pocket [chemical binding]; other site 288705000077 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288705000078 cleavage site 288705000079 active site 288705000080 substrate binding sites [chemical binding]; other site 288705000081 DEAD-like helicases superfamily; Region: DEXDc; smart00487 288705000082 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288705000083 ATP binding site [chemical binding]; other site 288705000084 putative Mg++ binding site [ion binding]; other site 288705000085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705000086 nucleotide binding region [chemical binding]; other site 288705000087 ATP-binding site [chemical binding]; other site 288705000088 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 288705000089 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 288705000090 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 288705000091 active site 288705000092 substrate binding site [chemical binding]; other site 288705000093 metal binding site [ion binding]; metal-binding site 288705000094 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 288705000095 active site 288705000096 substrate-binding site [chemical binding]; other site 288705000097 metal-binding site [ion binding] 288705000098 GTP binding site [chemical binding]; other site 288705000099 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 288705000100 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 288705000101 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 288705000102 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 288705000103 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 288705000104 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 288705000105 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 288705000106 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 288705000107 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 288705000108 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 288705000109 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 288705000110 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 288705000111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288705000112 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 288705000113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288705000114 Coenzyme A binding pocket [chemical binding]; other site 288705000115 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288705000116 Predicted membrane protein [Function unknown]; Region: COG1511 288705000117 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 288705000118 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 288705000119 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 288705000120 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 288705000121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705000122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705000123 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288705000124 EamA-like transporter family; Region: EamA; cl17759 288705000125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288705000126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288705000127 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 288705000128 putative dimerization interface [polypeptide binding]; other site 288705000129 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288705000130 catalytic core [active] 288705000131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288705000132 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288705000133 DNA binding site [nucleotide binding] 288705000134 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288705000135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705000136 active site 288705000137 phosphorylation site [posttranslational modification] 288705000138 intermolecular recognition site; other site 288705000139 dimerization interface [polypeptide binding]; other site 288705000140 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288705000141 DNA binding site [nucleotide binding] 288705000142 HAMP domain; Region: HAMP; pfam00672 288705000143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288705000144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288705000145 dimer interface [polypeptide binding]; other site 288705000146 phosphorylation site [posttranslational modification] 288705000147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288705000148 ATP binding site [chemical binding]; other site 288705000149 Mg2+ binding site [ion binding]; other site 288705000150 G-X-G motif; other site 288705000151 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 288705000152 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288705000153 active site 288705000154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705000155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705000156 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288705000157 MarR family; Region: MarR; pfam01047 288705000158 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 288705000159 N-acetyl-D-glucosamine binding site [chemical binding]; other site 288705000160 catalytic residue [active] 288705000161 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288705000162 active site 288705000163 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 288705000164 nucleoside/Zn binding site; other site 288705000165 dimer interface [polypeptide binding]; other site 288705000166 catalytic motif [active] 288705000167 GtrA-like protein; Region: GtrA; pfam04138 288705000168 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 288705000169 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 288705000170 conserved cys residue [active] 288705000171 Isochorismatase family; Region: Isochorismatase; pfam00857 288705000172 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 288705000173 catalytic triad [active] 288705000174 conserved cis-peptide bond; other site 288705000175 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 288705000176 putative hydrophobic ligand binding site [chemical binding]; other site 288705000177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705000178 dimerization interface [polypeptide binding]; other site 288705000179 putative DNA binding site [nucleotide binding]; other site 288705000180 putative Zn2+ binding site [ion binding]; other site 288705000181 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288705000182 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 288705000183 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 288705000184 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 288705000185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288705000186 ATP binding site [chemical binding]; other site 288705000187 putative Mg++ binding site [ion binding]; other site 288705000188 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705000189 nucleotide binding region [chemical binding]; other site 288705000190 ATP-binding site [chemical binding]; other site 288705000191 DEAD/H associated; Region: DEAD_assoc; pfam08494 288705000192 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 288705000193 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 288705000194 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 288705000195 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 288705000196 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 288705000197 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 288705000198 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 288705000199 active site 288705000200 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 288705000201 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 288705000202 active site 288705000203 acyl-coenzyme A oxidase; Region: PLN02526 288705000204 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705000205 active site 288705000206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705000207 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 288705000208 NAD(P) binding site [chemical binding]; other site 288705000209 active site 288705000210 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 288705000211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 288705000212 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 288705000213 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 288705000214 putative active site [active] 288705000215 catalytic site [active] 288705000216 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 288705000217 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 288705000218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288705000219 active site 288705000220 motif I; other site 288705000221 motif II; other site 288705000222 H+ Antiporter protein; Region: 2A0121; TIGR00900 288705000223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705000224 putative substrate translocation pore; other site 288705000225 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 288705000226 substrate binding site [chemical binding]; other site 288705000227 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 288705000228 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288705000229 putative substrate binding site [chemical binding]; other site 288705000230 putative ATP binding site [chemical binding]; other site 288705000231 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 288705000232 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 288705000233 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705000234 putative Zn2+ binding site [ion binding]; other site 288705000235 putative DNA binding site [nucleotide binding]; other site 288705000236 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288705000237 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288705000238 active site 288705000239 metal binding site [ion binding]; metal-binding site 288705000240 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 288705000241 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 288705000242 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 288705000243 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 288705000244 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 288705000245 synthetase active site [active] 288705000246 NTP binding site [chemical binding]; other site 288705000247 metal binding site [ion binding]; metal-binding site 288705000248 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 288705000249 catalytic residues [active] 288705000250 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 288705000251 putative active site [active] 288705000252 putative catalytic triad [active] 288705000253 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 288705000254 putative active site [active] 288705000255 putative catalytic triad [active] 288705000256 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 288705000257 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288705000258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288705000259 DNA binding site [nucleotide binding] 288705000260 domain linker motif; other site 288705000261 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288705000262 dimerization interface [polypeptide binding]; other site 288705000263 ligand binding site [chemical binding]; other site 288705000264 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 288705000265 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 288705000266 NAD binding site [chemical binding]; other site 288705000267 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 288705000268 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 288705000269 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 288705000270 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 288705000271 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 288705000272 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705000273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705000274 ABC-ATPase subunit interface; other site 288705000275 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705000276 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 288705000277 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 288705000278 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 288705000279 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 288705000280 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 288705000281 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 288705000282 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 288705000283 Sodium Bile acid symporter family; Region: SBF; cl17470 288705000284 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 288705000285 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 288705000286 dimerization interface [polypeptide binding]; other site 288705000287 DPS ferroxidase diiron center [ion binding]; other site 288705000288 ion pore; other site 288705000289 MMPL family; Region: MMPL; pfam03176 288705000290 MMPL family; Region: MMPL; pfam03176 288705000291 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288705000292 dimerization interface [polypeptide binding]; other site 288705000293 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 288705000294 polypeptide substrate binding site [polypeptide binding]; other site 288705000295 active site 288705000296 putative transposase OrfB; Reviewed; Region: PHA02517 288705000297 HTH-like domain; Region: HTH_21; pfam13276 288705000298 Integrase core domain; Region: rve; pfam00665 288705000299 Integrase core domain; Region: rve_3; pfam13683 288705000300 IPT/TIG domain; Region: TIG; pfam01833 288705000301 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 288705000302 Transposase IS200 like; Region: Y1_Tnp; pfam01797 288705000303 Transposase IS200 like; Region: Y1_Tnp; pfam01797 288705000304 Transposase; Region: HTH_Tnp_1; cl17663 288705000305 putative transposase OrfB; Reviewed; Region: PHA02517 288705000306 HTH-like domain; Region: HTH_21; pfam13276 288705000307 Integrase core domain; Region: rve; pfam00665 288705000308 Integrase core domain; Region: rve_3; pfam13683 288705000309 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 288705000310 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 288705000311 acyl-activating enzyme (AAE) consensus motif; other site 288705000312 AMP binding site [chemical binding]; other site 288705000313 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 288705000314 Condensation domain; Region: Condensation; pfam00668 288705000315 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 288705000316 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 288705000317 acyl-activating enzyme (AAE) consensus motif; other site 288705000318 AMP binding site [chemical binding]; other site 288705000319 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 288705000320 enterobactin exporter EntS; Provisional; Region: PRK10489 288705000321 enterobactin exporter EntS; Provisional; Region: PRK10489 288705000322 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 288705000323 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 288705000324 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 288705000325 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 288705000326 active site 288705000327 active site 288705000328 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 288705000329 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 288705000330 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 288705000331 active site 288705000332 catalytic site [active] 288705000333 Melibiase; Region: Melibiase; pfam02065 288705000334 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288705000335 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 288705000336 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 288705000337 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 288705000338 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 288705000339 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 288705000340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288705000341 Putative zinc-finger; Region: zf-HC2; pfam13490 288705000342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705000343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705000344 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288705000345 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 288705000346 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288705000347 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288705000348 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288705000349 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 288705000350 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 288705000351 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288705000352 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288705000353 nucleotide binding site [chemical binding]; other site 288705000354 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705000355 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 288705000356 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 288705000357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705000358 dimer interface [polypeptide binding]; other site 288705000359 conserved gate region; other site 288705000360 putative PBP binding loops; other site 288705000361 ABC-ATPase subunit interface; other site 288705000362 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705000363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705000364 dimer interface [polypeptide binding]; other site 288705000365 conserved gate region; other site 288705000366 putative PBP binding loops; other site 288705000367 ABC-ATPase subunit interface; other site 288705000368 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 288705000369 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 288705000370 catalytic residues [active] 288705000371 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 288705000372 hypothetical protein; Provisional; Region: PRK07236 288705000373 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288705000374 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288705000375 Predicted transcriptional regulators [Transcription]; Region: COG1695 288705000376 Transcriptional regulator PadR-like family; Region: PadR; cl17335 288705000377 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705000378 dimerization interface [polypeptide binding]; other site 288705000379 putative DNA binding site [nucleotide binding]; other site 288705000380 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288705000381 putative Zn2+ binding site [ion binding]; other site 288705000382 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 288705000383 putative hydrophobic ligand binding site [chemical binding]; other site 288705000384 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 288705000385 malate synthase; Validated; Region: PRK09255 288705000386 active site 288705000387 isocitrate lyase; Provisional; Region: PRK15063 288705000388 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 288705000389 tetramer interface [polypeptide binding]; other site 288705000390 active site 288705000391 Mg2+/Mn2+ binding site [ion binding]; other site 288705000392 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288705000393 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288705000394 non-specific DNA binding site [nucleotide binding]; other site 288705000395 salt bridge; other site 288705000396 sequence-specific DNA binding site [nucleotide binding]; other site 288705000397 Domain of unknown function (DUF955); Region: DUF955; pfam06114 288705000398 CAAX protease self-immunity; Region: Abi; pfam02517 288705000399 acyl-coenzyme A oxidase; Region: PLN02526 288705000400 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705000401 active site 288705000402 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 288705000403 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 288705000404 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 288705000405 acetoacetate decarboxylase; Provisional; Region: PRK02265 288705000406 enoyl-CoA hydratase; Provisional; Region: PRK08252 288705000407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288705000408 substrate binding site [chemical binding]; other site 288705000409 oxyanion hole (OAH) forming residues; other site 288705000410 trimer interface [polypeptide binding]; other site 288705000411 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 288705000412 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 288705000413 CoA-transferase family III; Region: CoA_transf_3; pfam02515 288705000414 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 288705000415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288705000416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288705000417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288705000418 dimerization interface [polypeptide binding]; other site 288705000419 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 288705000420 serpin-like protein; Provisional; Region: PHA02660 288705000421 reactive center loop; other site 288705000422 putative transposase OrfB; Reviewed; Region: PHA02517 288705000423 HTH-like domain; Region: HTH_21; pfam13276 288705000424 Integrase core domain; Region: rve; pfam00665 288705000425 Integrase core domain; Region: rve_3; pfam13683 288705000426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705000427 Transposase; Region: HTH_Tnp_1; cl17663 288705000428 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 288705000429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288705000430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288705000431 dimer interface [polypeptide binding]; other site 288705000432 phosphorylation site [posttranslational modification] 288705000433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288705000434 ATP binding site [chemical binding]; other site 288705000435 Mg2+ binding site [ion binding]; other site 288705000436 G-X-G motif; other site 288705000437 sensor protein QseC; Provisional; Region: PRK10337 288705000438 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288705000439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705000440 active site 288705000441 phosphorylation site [posttranslational modification] 288705000442 intermolecular recognition site; other site 288705000443 dimerization interface [polypeptide binding]; other site 288705000444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288705000445 DNA binding site [nucleotide binding] 288705000446 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288705000447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705000448 putative Zn2+ binding site [ion binding]; other site 288705000449 putative DNA binding site [nucleotide binding]; other site 288705000450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705000451 putative substrate translocation pore; other site 288705000452 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 288705000453 hydrophobic ligand binding site; other site 288705000454 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 288705000455 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 288705000456 diiron binding motif [ion binding]; other site 288705000457 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 288705000458 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 288705000459 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 288705000460 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 288705000461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288705000462 non-specific DNA binding site [nucleotide binding]; other site 288705000463 salt bridge; other site 288705000464 sequence-specific DNA binding site [nucleotide binding]; other site 288705000465 Cupin domain; Region: Cupin_2; pfam07883 288705000466 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 288705000467 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288705000468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288705000469 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 288705000470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288705000471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288705000472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288705000473 dimerization interface [polypeptide binding]; other site 288705000474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705000475 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288705000476 magnesium-transporting ATPase; Provisional; Region: PRK15122 288705000477 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 288705000478 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288705000479 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 288705000480 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 288705000481 Soluble P-type ATPase [General function prediction only]; Region: COG4087 288705000482 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 288705000483 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 288705000484 agmatinase; Region: agmatinase; TIGR01230 288705000485 oligomer interface [polypeptide binding]; other site 288705000486 putative active site [active] 288705000487 Mn binding site [ion binding]; other site 288705000488 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 288705000489 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288705000490 PYR/PP interface [polypeptide binding]; other site 288705000491 dimer interface [polypeptide binding]; other site 288705000492 TPP binding site [chemical binding]; other site 288705000493 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 288705000494 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 288705000495 TPP-binding site [chemical binding]; other site 288705000496 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 288705000497 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 288705000498 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 288705000499 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 288705000500 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288705000501 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 288705000502 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 288705000503 Protein of unknown function (DUF805); Region: DUF805; pfam05656 288705000504 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 288705000505 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 288705000506 active site 288705000507 substrate binding site [chemical binding]; other site 288705000508 cosubstrate binding site; other site 288705000509 catalytic site [active] 288705000510 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288705000511 Beta-lactamase; Region: Beta-lactamase; pfam00144 288705000512 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 288705000513 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 288705000514 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 288705000515 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 288705000516 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 288705000517 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 288705000518 putative active site [active] 288705000519 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 288705000520 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 288705000521 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 288705000522 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 288705000523 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 288705000524 putative active site [active] 288705000525 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 288705000526 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 288705000527 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 288705000528 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288705000529 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 288705000530 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 288705000531 purine monophosphate binding site [chemical binding]; other site 288705000532 dimer interface [polypeptide binding]; other site 288705000533 putative catalytic residues [active] 288705000534 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 288705000535 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288705000536 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288705000537 active site 288705000538 catalytic tetrad [active] 288705000539 isocitrate dehydrogenase; Validated; Region: PRK08299 288705000540 Predicted membrane protein [Function unknown]; Region: COG2259 288705000541 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 288705000542 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 288705000543 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 288705000544 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 288705000545 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 288705000546 TM-ABC transporter signature motif; other site 288705000547 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 288705000548 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 288705000549 TM-ABC transporter signature motif; other site 288705000550 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 288705000551 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 288705000552 Walker A/P-loop; other site 288705000553 ATP binding site [chemical binding]; other site 288705000554 Q-loop/lid; other site 288705000555 ABC transporter signature motif; other site 288705000556 Walker B; other site 288705000557 D-loop; other site 288705000558 H-loop/switch region; other site 288705000559 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 288705000560 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 288705000561 Walker A/P-loop; other site 288705000562 ATP binding site [chemical binding]; other site 288705000563 Q-loop/lid; other site 288705000564 ABC transporter signature motif; other site 288705000565 Walker B; other site 288705000566 D-loop; other site 288705000567 H-loop/switch region; other site 288705000568 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288705000569 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288705000570 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288705000571 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288705000572 Walker A/P-loop; other site 288705000573 ATP binding site [chemical binding]; other site 288705000574 Q-loop/lid; other site 288705000575 ABC transporter signature motif; other site 288705000576 Walker B; other site 288705000577 D-loop; other site 288705000578 H-loop/switch region; other site 288705000579 FtsX-like permease family; Region: FtsX; pfam02687 288705000580 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 288705000581 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 288705000582 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 288705000583 putative ligand binding site [chemical binding]; other site 288705000584 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 288705000585 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 288705000586 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 288705000587 TM-ABC transporter signature motif; other site 288705000588 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 288705000589 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 288705000590 Walker A/P-loop; other site 288705000591 ATP binding site [chemical binding]; other site 288705000592 Q-loop/lid; other site 288705000593 ABC transporter signature motif; other site 288705000594 Walker B; other site 288705000595 D-loop; other site 288705000596 H-loop/switch region; other site 288705000597 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 288705000598 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705000599 dimerization interface [polypeptide binding]; other site 288705000600 putative DNA binding site [nucleotide binding]; other site 288705000601 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288705000602 putative Zn2+ binding site [ion binding]; other site 288705000603 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288705000604 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288705000605 nucleotide binding site [chemical binding]; other site 288705000606 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 288705000607 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 288705000608 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 288705000609 trimer interface [polypeptide binding]; other site 288705000610 putative metal binding site [ion binding]; other site 288705000611 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 288705000612 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 288705000613 active site 288705000614 cosubstrate binding site; other site 288705000615 catalytic site [active] 288705000616 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 288705000617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 288705000618 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288705000619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288705000620 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 288705000621 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 288705000622 dimer interface [polypeptide binding]; other site 288705000623 active site 288705000624 glycine-pyridoxal phosphate binding site [chemical binding]; other site 288705000625 folate binding site [chemical binding]; other site 288705000626 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 288705000627 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 288705000628 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 288705000629 homodimer interface [polypeptide binding]; other site 288705000630 NADP binding site [chemical binding]; other site 288705000631 substrate binding site [chemical binding]; other site 288705000632 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 288705000633 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 288705000634 tetramer interface [polypeptide binding]; other site 288705000635 active site 288705000636 Mg2+/Mn2+ binding site [ion binding]; other site 288705000637 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 288705000638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705000639 MMPL family; Region: MMPL; pfam03176 288705000640 MMPL family; Region: MMPL; pfam03176 288705000641 nodulation ABC transporter NodI; Provisional; Region: PRK13537 288705000642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705000643 Walker A/P-loop; other site 288705000644 ATP binding site [chemical binding]; other site 288705000645 Q-loop/lid; other site 288705000646 ABC transporter signature motif; other site 288705000647 Walker B; other site 288705000648 D-loop; other site 288705000649 H-loop/switch region; other site 288705000650 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 288705000651 ABC-2 type transporter; Region: ABC2_membrane; cl17235 288705000652 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 288705000653 ABC-2 type transporter; Region: ABC2_membrane; cl17235 288705000654 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288705000655 active site 288705000656 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288705000657 active site 288705000658 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 288705000659 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 288705000660 active site 288705000661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288705000662 sequence-specific DNA binding site [nucleotide binding]; other site 288705000663 salt bridge; other site 288705000664 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288705000665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 288705000666 intermolecular recognition site; other site 288705000667 active site 288705000668 dimerization interface [polypeptide binding]; other site 288705000669 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288705000670 DNA binding residues [nucleotide binding] 288705000671 dimerization interface [polypeptide binding]; other site 288705000672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705000673 phosphorylation site [posttranslational modification] 288705000674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288705000675 Histidine kinase; Region: HisKA_3; pfam07730 288705000676 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 288705000677 putative active site [active] 288705000678 putative catalytic site [active] 288705000679 putative DNA binding site [nucleotide binding]; other site 288705000680 putative phosphate binding site [ion binding]; other site 288705000681 metal binding site A [ion binding]; metal-binding site 288705000682 putative AP binding site [nucleotide binding]; other site 288705000683 putative metal binding site B [ion binding]; other site 288705000684 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 288705000685 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 288705000686 active site 288705000687 HIGH motif; other site 288705000688 dimer interface [polypeptide binding]; other site 288705000689 KMSKS motif; other site 288705000690 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 288705000691 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 288705000692 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 288705000693 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 288705000694 MgtC family; Region: MgtC; pfam02308 288705000695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288705000696 Coenzyme A binding pocket [chemical binding]; other site 288705000697 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 288705000698 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 288705000699 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 288705000700 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 288705000701 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 288705000702 L-aspartate oxidase; Provisional; Region: PRK06175 288705000703 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 288705000704 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 288705000705 putative Iron-sulfur protein interface [polypeptide binding]; other site 288705000706 putative proximal heme binding site [chemical binding]; other site 288705000707 putative SdhC-like subunit interface [polypeptide binding]; other site 288705000708 putative distal heme binding site [chemical binding]; other site 288705000709 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 288705000710 putative Iron-sulfur protein interface [polypeptide binding]; other site 288705000711 putative proximal heme binding site [chemical binding]; other site 288705000712 putative SdhD-like interface [polypeptide binding]; other site 288705000713 putative distal heme binding site [chemical binding]; other site 288705000714 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 288705000715 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288705000716 active site 288705000717 Cupin domain; Region: Cupin_2; cl17218 288705000718 Tetratrico peptide repeat; Region: TPR_5; pfam12688 288705000719 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 288705000720 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 288705000721 metal binding site [ion binding]; metal-binding site 288705000722 putative dimer interface [polypeptide binding]; other site 288705000723 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 288705000724 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288705000725 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 288705000726 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288705000727 NAD(P) binding site [chemical binding]; other site 288705000728 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288705000729 MarR family; Region: MarR; pfam01047 288705000730 OsmC-like protein; Region: OsmC; cl00767 288705000731 OsmC-like protein; Region: OsmC; cl00767 288705000732 Prostaglandin dehydrogenases; Region: PGDH; cd05288 288705000733 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 288705000734 NAD(P) binding site [chemical binding]; other site 288705000735 substrate binding site [chemical binding]; other site 288705000736 dimer interface [polypeptide binding]; other site 288705000737 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 288705000738 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 288705000739 putative transposase OrfB; Reviewed; Region: PHA02517 288705000740 HTH-like domain; Region: HTH_21; pfam13276 288705000741 Integrase core domain; Region: rve; pfam00665 288705000742 Integrase core domain; Region: rve_3; pfam13683 288705000743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705000744 ABC transporter signature motif; other site 288705000745 Walker B; other site 288705000746 D-loop; other site 288705000747 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705000748 H-loop/switch region; other site 288705000749 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 288705000750 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 288705000751 TM-ABC transporter signature motif; other site 288705000752 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 288705000753 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 288705000754 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 288705000755 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 288705000756 TM-ABC transporter signature motif; other site 288705000757 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 288705000758 active site 288705000759 catalytic motif [active] 288705000760 Zn binding site [ion binding]; other site 288705000761 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 288705000762 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 288705000763 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 288705000764 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 288705000765 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 288705000766 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 288705000767 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 288705000768 adenosine deaminase; Provisional; Region: PRK09358 288705000769 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 288705000770 active site 288705000771 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 288705000772 homodimer interface [polypeptide binding]; other site 288705000773 metal binding site [ion binding]; metal-binding site 288705000774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705000775 Coenzyme A binding pocket [chemical binding]; other site 288705000776 Predicted transcriptional regulators [Transcription]; Region: COG1695 288705000777 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288705000778 enolase; Provisional; Region: eno; PRK00077 288705000779 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 288705000780 dimer interface [polypeptide binding]; other site 288705000781 metal binding site [ion binding]; metal-binding site 288705000782 substrate binding pocket [chemical binding]; other site 288705000783 Septum formation initiator; Region: DivIC; pfam04977 288705000784 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 288705000785 Protein of unknown function (DUF501); Region: DUF501; pfam04417 288705000786 exopolyphosphatase; Region: exo_poly_only; TIGR03706 288705000787 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 288705000788 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 288705000789 active site 288705000790 catalytic residues [active] 288705000791 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 288705000792 Serine hydrolase; Region: Ser_hydrolase; cl17834 288705000793 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288705000794 Trypsin; Region: Trypsin; pfam00089 288705000795 cleavage site 288705000796 active site 288705000797 substrate binding sites [chemical binding]; other site 288705000798 putative transposase OrfB; Reviewed; Region: PHA02517 288705000799 HTH-like domain; Region: HTH_21; pfam13276 288705000800 Integrase core domain; Region: rve; pfam00665 288705000801 Integrase core domain; Region: rve_3; pfam13683 288705000802 Protein of unknown function (DUF998); Region: DUF998; pfam06197 288705000803 Predicted membrane protein [Function unknown]; Region: COG3371 288705000804 Thioredoxin; Region: Thioredoxin_4; pfam13462 288705000805 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 288705000806 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 288705000807 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 288705000808 active site 288705000809 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 288705000810 Part of AAA domain; Region: AAA_19; pfam13245 288705000811 Family description; Region: UvrD_C_2; pfam13538 288705000812 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 288705000813 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 288705000814 CoA-ligase; Region: Ligase_CoA; pfam00549 288705000815 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 288705000816 CoA binding domain; Region: CoA_binding; smart00881 288705000817 CoA binding domain; Region: CoA_binding; cl17356 288705000818 CoA-ligase; Region: Ligase_CoA; pfam00549 288705000819 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288705000820 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705000821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705000822 Walker A/P-loop; other site 288705000823 ATP binding site [chemical binding]; other site 288705000824 Q-loop/lid; other site 288705000825 ABC transporter signature motif; other site 288705000826 Walker B; other site 288705000827 D-loop; other site 288705000828 H-loop/switch region; other site 288705000829 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288705000830 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705000831 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 288705000832 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288705000833 Walker A/P-loop; other site 288705000834 ATP binding site [chemical binding]; other site 288705000835 Q-loop/lid; other site 288705000836 ABC transporter signature motif; other site 288705000837 Walker B; other site 288705000838 D-loop; other site 288705000839 H-loop/switch region; other site 288705000840 Ricin-type beta-trefoil; Region: RICIN; smart00458 288705000841 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 288705000842 putative sugar binding sites [chemical binding]; other site 288705000843 Q-X-W motif; other site 288705000844 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 288705000845 putative sugar binding site [chemical binding]; other site 288705000846 catalytic residues [active] 288705000847 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 288705000848 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 288705000849 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288705000850 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 288705000851 ATP binding site [chemical binding]; other site 288705000852 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288705000853 substrate binding site [chemical binding]; other site 288705000854 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288705000855 PYR/PP interface [polypeptide binding]; other site 288705000856 dimer interface [polypeptide binding]; other site 288705000857 TPP binding site [chemical binding]; other site 288705000858 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 288705000859 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 288705000860 TPP-binding site [chemical binding]; other site 288705000861 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 288705000862 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288705000863 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288705000864 KduI/IolB family; Region: KduI; pfam04962 288705000865 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288705000866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705000867 DNA-binding site [nucleotide binding]; DNA binding site 288705000868 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 288705000869 putative transposase OrfB; Reviewed; Region: PHA02517 288705000870 HTH-like domain; Region: HTH_21; pfam13276 288705000871 Integrase core domain; Region: rve; pfam00665 288705000872 Integrase core domain; Region: rve_3; pfam13683 288705000873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705000874 Transposase; Region: HTH_Tnp_1; cl17663 288705000875 carbon starvation protein A; Provisional; Region: PRK15015 288705000876 Carbon starvation protein CstA; Region: CstA; pfam02554 288705000877 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 288705000878 Protein of unknown function (DUF466); Region: DUF466; pfam04328 288705000879 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 288705000880 classical (c) SDRs; Region: SDR_c; cd05233 288705000881 NAD(P) binding site [chemical binding]; other site 288705000882 active site 288705000883 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288705000884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705000885 ABC transporter signature motif; other site 288705000886 Walker B; other site 288705000887 D-loop; other site 288705000888 H-loop/switch region; other site 288705000889 Histidine kinase; Region: HisKA_3; pfam07730 288705000890 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 288705000891 ATP binding site [chemical binding]; other site 288705000892 Mg2+ binding site [ion binding]; other site 288705000893 G-X-G motif; other site 288705000894 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288705000895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705000896 active site 288705000897 phosphorylation site [posttranslational modification] 288705000898 intermolecular recognition site; other site 288705000899 dimerization interface [polypeptide binding]; other site 288705000900 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288705000901 DNA binding residues [nucleotide binding] 288705000902 dimerization interface [polypeptide binding]; other site 288705000903 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 288705000904 CoenzymeA binding site [chemical binding]; other site 288705000905 subunit interaction site [polypeptide binding]; other site 288705000906 PHB binding site; other site 288705000907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 288705000908 sequence-specific DNA binding site [nucleotide binding]; other site 288705000909 salt bridge; other site 288705000910 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 288705000911 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 288705000912 Uncharacterized conserved protein [Function unknown]; Region: COG3379 288705000913 Integrase core domain; Region: rve_3; pfam13683 288705000914 HTH-like domain; Region: HTH_21; pfam13276 288705000915 Integrase core domain; Region: rve; pfam00665 288705000916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705000917 Transposase; Region: HTH_Tnp_1; cl17663 288705000918 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 288705000919 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 288705000920 Walker A/P-loop; other site 288705000921 ATP binding site [chemical binding]; other site 288705000922 Q-loop/lid; other site 288705000923 ABC transporter signature motif; other site 288705000924 Walker B; other site 288705000925 D-loop; other site 288705000926 H-loop/switch region; other site 288705000927 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 288705000928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705000929 dimer interface [polypeptide binding]; other site 288705000930 conserved gate region; other site 288705000931 putative PBP binding loops; other site 288705000932 ABC-ATPase subunit interface; other site 288705000933 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 288705000934 TAP-like protein; Region: Abhydrolase_4; pfam08386 288705000935 DNA polymerase III subunit delta'; Validated; Region: PRK07940 288705000936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705000937 Walker A motif; other site 288705000938 ATP binding site [chemical binding]; other site 288705000939 Walker B motif; other site 288705000940 arginine finger; other site 288705000941 thymidylate kinase; Validated; Region: tmk; PRK00698 288705000942 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 288705000943 TMP-binding site; other site 288705000944 ATP-binding site [chemical binding]; other site 288705000945 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288705000946 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 288705000947 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705000948 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705000949 catalytic residue [active] 288705000950 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705000951 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 288705000952 Putative methyltransferase; Region: Methyltransf_4; cl17290 288705000953 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288705000954 catalytic core [active] 288705000955 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 288705000956 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 288705000957 PhoU domain; Region: PhoU; pfam01895 288705000958 PhoU domain; Region: PhoU; pfam01895 288705000959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288705000960 dimer interface [polypeptide binding]; other site 288705000961 phosphorylation site [posttranslational modification] 288705000962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288705000963 ATP binding site [chemical binding]; other site 288705000964 Mg2+ binding site [ion binding]; other site 288705000965 G-X-G motif; other site 288705000966 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288705000967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705000968 active site 288705000969 phosphorylation site [posttranslational modification] 288705000970 intermolecular recognition site; other site 288705000971 dimerization interface [polypeptide binding]; other site 288705000972 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288705000973 DNA binding site [nucleotide binding] 288705000974 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 288705000975 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 288705000976 substrate binding site; other site 288705000977 dimer interface; other site 288705000978 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 288705000979 homotrimer interaction site [polypeptide binding]; other site 288705000980 zinc binding site [ion binding]; other site 288705000981 CDP-binding sites; other site 288705000982 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 288705000983 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 288705000984 active site 288705000985 HIGH motif; other site 288705000986 nucleotide binding site [chemical binding]; other site 288705000987 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 288705000988 KMSKS motif; other site 288705000989 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 288705000990 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 288705000991 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 288705000992 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 288705000993 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 288705000994 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 288705000995 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 288705000996 active site 288705000997 catalytic site [active] 288705000998 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 288705000999 active site 288705001000 barstar interaction site; other site 288705001001 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 288705001002 putative RNAase interaction site [polypeptide binding]; other site 288705001003 Transposase; Region: HTH_Tnp_1; cl17663 288705001004 HTH-like domain; Region: HTH_21; pfam13276 288705001005 Integrase core domain; Region: rve; pfam00665 288705001006 Integrase core domain; Region: rve_3; pfam13683 288705001007 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 288705001008 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288705001009 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 288705001010 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705001011 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 288705001012 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705001013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705001014 dimer interface [polypeptide binding]; other site 288705001015 conserved gate region; other site 288705001016 putative PBP binding loops; other site 288705001017 ABC-ATPase subunit interface; other site 288705001018 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705001019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705001020 dimer interface [polypeptide binding]; other site 288705001021 conserved gate region; other site 288705001022 putative PBP binding loops; other site 288705001023 ABC-ATPase subunit interface; other site 288705001024 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 288705001025 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 288705001026 active site 288705001027 homodimer interface [polypeptide binding]; other site 288705001028 catalytic site [active] 288705001029 acceptor binding site [chemical binding]; other site 288705001030 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 288705001031 active site 288705001032 catalytic site [active] 288705001033 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 288705001034 glycogen branching enzyme; Provisional; Region: PRK14705 288705001035 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 288705001036 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 288705001037 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 288705001038 active site 288705001039 catalytic site [active] 288705001040 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 288705001041 Epoxide hydrolase N terminus; Region: EHN; pfam06441 288705001042 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288705001043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705001044 Transposase; Region: HTH_Tnp_1; cl17663 288705001045 putative transposase OrfB; Reviewed; Region: PHA02517 288705001046 HTH-like domain; Region: HTH_21; pfam13276 288705001047 Integrase core domain; Region: rve; pfam00665 288705001048 Integrase core domain; Region: rve_3; pfam13683 288705001049 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288705001050 Beta-lactamase; Region: Beta-lactamase; pfam00144 288705001051 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 288705001052 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 288705001053 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 288705001054 putative catalytic motif [active] 288705001055 putative substrate binding site [chemical binding]; other site 288705001056 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 288705001057 FAD binding domain; Region: FAD_binding_4; pfam01565 288705001058 FAD binding domain; Region: FAD_binding_4; pfam01565 288705001059 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 288705001060 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 288705001061 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 288705001062 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 288705001063 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 288705001064 Walker A/P-loop; other site 288705001065 ATP binding site [chemical binding]; other site 288705001066 Q-loop/lid; other site 288705001067 ABC transporter signature motif; other site 288705001068 Walker B; other site 288705001069 D-loop; other site 288705001070 H-loop/switch region; other site 288705001071 TOBE domain; Region: TOBE_2; pfam08402 288705001072 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 288705001073 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 288705001074 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 288705001075 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 288705001076 active site 288705001077 homotetramer interface [polypeptide binding]; other site 288705001078 Thioredoxin; Region: Thioredoxin_4; cl17273 288705001079 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 288705001080 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 288705001081 catalytic residues [active] 288705001082 Excalibur calcium-binding domain; Region: Excalibur; smart00894 288705001083 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 288705001084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705001085 putative substrate translocation pore; other site 288705001086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705001087 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288705001088 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705001089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705001090 ABC transporter signature motif; other site 288705001091 Walker B; other site 288705001092 D-loop; other site 288705001093 H-loop/switch region; other site 288705001094 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288705001095 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705001096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705001097 Walker A/P-loop; other site 288705001098 ATP binding site [chemical binding]; other site 288705001099 Q-loop/lid; other site 288705001100 ABC transporter signature motif; other site 288705001101 Walker B; other site 288705001102 D-loop; other site 288705001103 H-loop/switch region; other site 288705001104 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 288705001105 CutC family; Region: CutC; cl01218 288705001106 Asp23 family; Region: Asp23; cl00574 288705001107 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 288705001108 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288705001109 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288705001110 DNA binding residues [nucleotide binding] 288705001111 CsbD-like; Region: CsbD; pfam05532 288705001112 Asp23 family; Region: Asp23; pfam03780 288705001113 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 288705001114 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 288705001115 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 288705001116 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 288705001117 putative DNA binding site [nucleotide binding]; other site 288705001118 catalytic residue [active] 288705001119 putative H2TH interface [polypeptide binding]; other site 288705001120 putative catalytic residues [active] 288705001121 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 288705001122 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 288705001123 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 288705001124 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 288705001125 FAD binding pocket [chemical binding]; other site 288705001126 FAD binding motif [chemical binding]; other site 288705001127 phosphate binding motif [ion binding]; other site 288705001128 NAD binding pocket [chemical binding]; other site 288705001129 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 288705001130 ligand binding site [chemical binding]; other site 288705001131 active site 288705001132 UGI interface [polypeptide binding]; other site 288705001133 catalytic site [active] 288705001134 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 288705001135 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 288705001136 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 288705001137 DNA-binding site [nucleotide binding]; DNA binding site 288705001138 RNA-binding motif; other site 288705001139 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 288705001140 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 288705001141 ring oligomerisation interface [polypeptide binding]; other site 288705001142 ATP/Mg binding site [chemical binding]; other site 288705001143 stacking interactions; other site 288705001144 hinge regions; other site 288705001145 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288705001146 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288705001147 DNA binding site [nucleotide binding] 288705001148 domain linker motif; other site 288705001149 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 288705001150 putative dimerization interface [polypeptide binding]; other site 288705001151 putative ligand binding site [chemical binding]; other site 288705001152 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 288705001153 RNA/DNA hybrid binding site [nucleotide binding]; other site 288705001154 active site 288705001155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288705001156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288705001157 dimerization interface [polypeptide binding]; other site 288705001158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288705001159 dimer interface [polypeptide binding]; other site 288705001160 phosphorylation site [posttranslational modification] 288705001161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288705001162 ATP binding site [chemical binding]; other site 288705001163 Mg2+ binding site [ion binding]; other site 288705001164 G-X-G motif; other site 288705001165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288705001166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705001167 active site 288705001168 phosphorylation site [posttranslational modification] 288705001169 intermolecular recognition site; other site 288705001170 dimerization interface [polypeptide binding]; other site 288705001171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288705001172 DNA binding site [nucleotide binding] 288705001173 DNA repair helicase rad25; Region: rad25; TIGR00603 288705001174 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 288705001175 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 288705001176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 288705001177 ATP binding site [chemical binding]; other site 288705001178 putative Mg++ binding site [ion binding]; other site 288705001179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705001180 nucleotide binding region [chemical binding]; other site 288705001181 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 288705001182 WYL domain; Region: WYL; pfam13280 288705001183 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 288705001184 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 288705001185 DNA-binding site [nucleotide binding]; DNA binding site 288705001186 RNA-binding motif; other site 288705001187 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 288705001188 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705001189 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705001190 catalytic residue [active] 288705001191 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705001192 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 288705001193 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 288705001194 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 288705001195 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 288705001196 Peptidase family M23; Region: Peptidase_M23; pfam01551 288705001197 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 288705001198 NlpC/P60 family; Region: NLPC_P60; pfam00877 288705001199 NlpC/P60 family; Region: NLPC_P60; cl17555 288705001200 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 288705001201 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 288705001202 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 288705001203 active site 288705001204 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288705001205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288705001206 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 288705001207 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 288705001208 dimer interface [polypeptide binding]; other site 288705001209 putative functional site; other site 288705001210 putative MPT binding site; other site 288705001211 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 288705001212 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 288705001213 putative molybdopterin cofactor binding site; other site 288705001214 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 288705001215 molybdopterin cofactor binding site; other site 288705001216 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 288705001217 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 288705001218 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 288705001219 active site 288705001220 catalytic site [active] 288705001221 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 288705001222 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 288705001223 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288705001224 active site 288705001225 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288705001226 catalytic tetrad [active] 288705001227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705001228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705001229 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 288705001230 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288705001231 Walker A/P-loop; other site 288705001232 ATP binding site [chemical binding]; other site 288705001233 Q-loop/lid; other site 288705001234 ABC transporter signature motif; other site 288705001235 Walker B; other site 288705001236 D-loop; other site 288705001237 H-loop/switch region; other site 288705001238 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 288705001239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705001240 dimer interface [polypeptide binding]; other site 288705001241 conserved gate region; other site 288705001242 putative PBP binding loops; other site 288705001243 ABC-ATPase subunit interface; other site 288705001244 Integrase core domain; Region: rve; pfam00665 288705001245 Integrase core domain; Region: rve_3; pfam13683 288705001246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705001247 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 288705001248 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 288705001249 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288705001250 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 288705001251 putative ADP-binding pocket [chemical binding]; other site 288705001252 acyl-coenzyme A oxidase; Region: PLN02526 288705001253 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705001254 active site 288705001255 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 288705001256 Peptidase family M23; Region: Peptidase_M23; pfam01551 288705001257 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 288705001258 rRNA interaction site [nucleotide binding]; other site 288705001259 S8 interaction site; other site 288705001260 putative laminin-1 binding site; other site 288705001261 elongation factor Ts; Provisional; Region: tsf; PRK09377 288705001262 UBA/TS-N domain; Region: UBA; pfam00627 288705001263 Elongation factor TS; Region: EF_TS; pfam00889 288705001264 Elongation factor TS; Region: EF_TS; pfam00889 288705001265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705001266 dimerization interface [polypeptide binding]; other site 288705001267 putative DNA binding site [nucleotide binding]; other site 288705001268 putative Zn2+ binding site [ion binding]; other site 288705001269 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 288705001270 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 288705001271 putative nucleotide binding site [chemical binding]; other site 288705001272 uridine monophosphate binding site [chemical binding]; other site 288705001273 homohexameric interface [polypeptide binding]; other site 288705001274 ribosome recycling factor; Reviewed; Region: frr; PRK00083 288705001275 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 288705001276 hinge region; other site 288705001277 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 288705001278 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 288705001279 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 288705001280 DivIVA domain; Region: DivI1A_domain; TIGR03544 288705001281 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 288705001282 Na binding site [ion binding]; other site 288705001283 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 288705001284 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 288705001285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705001286 active site 288705001287 phosphorylation site [posttranslational modification] 288705001288 intermolecular recognition site; other site 288705001289 dimerization interface [polypeptide binding]; other site 288705001290 LytTr DNA-binding domain; Region: LytTR; smart00850 288705001291 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 288705001292 Histidine kinase; Region: His_kinase; pfam06580 288705001293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288705001294 ATP binding site [chemical binding]; other site 288705001295 Mg2+ binding site [ion binding]; other site 288705001296 G-X-G motif; other site 288705001297 Protein of unknown function, DUF485; Region: DUF485; pfam04341 288705001298 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 288705001299 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 288705001300 Na binding site [ion binding]; other site 288705001301 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 288705001302 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 288705001303 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 288705001304 AsnC family; Region: AsnC_trans_reg; pfam01037 288705001305 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 288705001306 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 288705001307 tetramer interface [polypeptide binding]; other site 288705001308 TPP-binding site [chemical binding]; other site 288705001309 heterodimer interface [polypeptide binding]; other site 288705001310 phosphorylation loop region [posttranslational modification] 288705001311 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 288705001312 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 288705001313 alpha subunit interface [polypeptide binding]; other site 288705001314 TPP binding site [chemical binding]; other site 288705001315 heterodimer interface [polypeptide binding]; other site 288705001316 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288705001317 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 288705001318 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288705001319 E3 interaction surface; other site 288705001320 lipoyl attachment site [posttranslational modification]; other site 288705001321 e3 binding domain; Region: E3_binding; pfam02817 288705001322 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 288705001323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705001324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705001325 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 288705001326 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 288705001327 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 288705001328 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 288705001329 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288705001330 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 288705001331 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 288705001332 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 288705001333 carboxyltransferase (CT) interaction site; other site 288705001334 biotinylation site [posttranslational modification]; other site 288705001335 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288705001336 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705001337 active site 288705001338 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 288705001339 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 288705001340 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 288705001341 putative active site [active] 288705001342 putative catalytic site [active] 288705001343 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 288705001344 biotin synthase; Validated; Region: PRK06256 288705001345 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288705001346 FeS/SAM binding site; other site 288705001347 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 288705001348 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288705001349 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 288705001350 inhibitor-cofactor binding pocket; inhibition site 288705001351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705001352 catalytic residue [active] 288705001353 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705001354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705001355 catalytic residue [active] 288705001356 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705001357 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 288705001358 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 288705001359 active site 288705001360 metal binding site [ion binding]; metal-binding site 288705001361 Domain of unknown function (DUF222); Region: DUF222; pfam02720 288705001362 putative transposase OrfB; Reviewed; Region: PHA02517 288705001363 HTH-like domain; Region: HTH_21; pfam13276 288705001364 Integrase core domain; Region: rve; pfam00665 288705001365 Integrase core domain; Region: rve_3; pfam13683 288705001366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705001367 Transposase; Region: HTH_Tnp_1; cl17663 288705001368 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 288705001369 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288705001370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705001371 homodimer interface [polypeptide binding]; other site 288705001372 catalytic residue [active] 288705001373 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 288705001374 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 288705001375 tetramer interface [polypeptide binding]; other site 288705001376 TPP-binding site [chemical binding]; other site 288705001377 heterodimer interface [polypeptide binding]; other site 288705001378 phosphorylation loop region [posttranslational modification] 288705001379 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 288705001380 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 288705001381 alpha subunit interface [polypeptide binding]; other site 288705001382 TPP binding site [chemical binding]; other site 288705001383 heterodimer interface [polypeptide binding]; other site 288705001384 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288705001385 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 288705001386 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288705001387 E3 interaction surface; other site 288705001388 lipoyl attachment site [posttranslational modification]; other site 288705001389 e3 binding domain; Region: E3_binding; pfam02817 288705001390 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 288705001391 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 288705001392 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288705001393 Part of AAA domain; Region: AAA_19; pfam13245 288705001394 Family description; Region: UvrD_C_2; pfam13538 288705001395 benzoate transport; Region: 2A0115; TIGR00895 288705001396 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 288705001397 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288705001398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705001399 homodimer interface [polypeptide binding]; other site 288705001400 catalytic residue [active] 288705001401 putative transposase OrfB; Reviewed; Region: PHA02517 288705001402 HTH-like domain; Region: HTH_21; pfam13276 288705001403 Integrase core domain; Region: rve; pfam00665 288705001404 Integrase core domain; Region: rve_3; pfam13683 288705001405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705001406 Transposase; Region: HTH_Tnp_1; cl17663 288705001407 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 288705001408 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 288705001409 metal-binding site [ion binding] 288705001410 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288705001411 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 288705001412 metal-binding site [ion binding] 288705001413 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 288705001414 putative homodimer interface [polypeptide binding]; other site 288705001415 putative homotetramer interface [polypeptide binding]; other site 288705001416 putative allosteric switch controlling residues; other site 288705001417 putative metal binding site [ion binding]; other site 288705001418 putative homodimer-homodimer interface [polypeptide binding]; other site 288705001419 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 288705001420 DNA-binding interface [nucleotide binding]; DNA binding site 288705001421 tetracycline repressor protein TetR; Provisional; Region: PRK13756 288705001422 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705001423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705001424 ABC-ATPase subunit interface; other site 288705001425 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705001426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288705001427 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 288705001428 ABC-ATPase subunit interface; other site 288705001429 putative PBP binding loops; other site 288705001430 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 288705001431 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 288705001432 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705001433 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705001434 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 288705001435 Helix-turn-helix domain; Region: HTH_28; pfam13518 288705001436 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 288705001437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705001438 Transposase; Region: HTH_Tnp_1; cl17663 288705001439 putative transposase OrfB; Reviewed; Region: PHA02517 288705001440 HTH-like domain; Region: HTH_21; pfam13276 288705001441 Integrase core domain; Region: rve; pfam00665 288705001442 Integrase core domain; Region: rve_3; pfam13683 288705001443 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705001444 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 288705001445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 288705001446 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 288705001447 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288705001448 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 288705001449 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288705001450 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288705001451 ligand binding site [chemical binding]; other site 288705001452 dimerization interface [polypeptide binding]; other site 288705001453 PQQ-like domain; Region: PQQ_2; pfam13360 288705001454 PQQ-like domain; Region: PQQ_2; pfam13360 288705001455 short chain dehydrogenase; Provisional; Region: PRK06057 288705001456 classical (c) SDRs; Region: SDR_c; cd05233 288705001457 NAD(P) binding site [chemical binding]; other site 288705001458 active site 288705001459 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288705001460 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 288705001461 NAD(P) binding site [chemical binding]; other site 288705001462 catalytic residues [active] 288705001463 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 288705001464 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 288705001465 catalytic triad [active] 288705001466 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 288705001467 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 288705001468 ethanolamine permease; Region: 2A0305; TIGR00908 288705001469 Transcriptional regulators [Transcription]; Region: FadR; COG2186 288705001470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705001471 DNA-binding site [nucleotide binding]; DNA binding site 288705001472 FCD domain; Region: FCD; pfam07729 288705001473 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 288705001474 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288705001475 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 288705001476 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 288705001477 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705001478 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288705001479 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 288705001480 FCD domain; Region: FCD; pfam07729 288705001481 putative transposase OrfB; Reviewed; Region: PHA02517 288705001482 HTH-like domain; Region: HTH_21; pfam13276 288705001483 Integrase core domain; Region: rve; pfam00665 288705001484 Integrase core domain; Region: rve_3; pfam13683 288705001485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705001486 Transposase; Region: HTH_Tnp_1; cl17663 288705001487 Phosphoesterase family; Region: Phosphoesterase; pfam04185 288705001488 Phosphoesterase family; Region: Phosphoesterase; pfam04185 288705001489 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 288705001490 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 288705001491 NAD(P) binding site [chemical binding]; other site 288705001492 Predicted transcriptional regulators [Transcription]; Region: COG1695 288705001493 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288705001494 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288705001495 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288705001496 Walker A/P-loop; other site 288705001497 ATP binding site [chemical binding]; other site 288705001498 Q-loop/lid; other site 288705001499 ABC transporter signature motif; other site 288705001500 Walker B; other site 288705001501 D-loop; other site 288705001502 H-loop/switch region; other site 288705001503 adenylosuccinate lyase; Provisional; Region: PRK09285 288705001504 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 288705001505 tetramer interface [polypeptide binding]; other site 288705001506 Membrane protein of unknown function; Region: DUF360; pfam04020 288705001507 putative transposase OrfB; Reviewed; Region: PHA02517 288705001508 HTH-like domain; Region: HTH_21; pfam13276 288705001509 Integrase core domain; Region: rve; pfam00665 288705001510 Integrase core domain; Region: rve_3; pfam13683 288705001511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705001512 Domain of unknown function (DUF222); Region: DUF222; pfam02720 288705001513 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 288705001514 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 288705001515 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 288705001516 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 288705001517 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 288705001518 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 288705001519 active site 288705001520 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 288705001521 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 288705001522 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 288705001523 putative substrate binding region [chemical binding]; other site 288705001524 putative substrate binding region [chemical binding]; other site 288705001525 MarR family; Region: MarR_2; cl17246 288705001526 YCII-related domain; Region: YCII; cl00999 288705001527 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 288705001528 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 288705001529 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 288705001530 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 288705001531 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288705001532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705001533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705001534 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 288705001535 Predicted transcriptional regulators [Transcription]; Region: COG1695 288705001536 Transcriptional regulator PadR-like family; Region: PadR; cl17335 288705001537 prolyl-tRNA synthetase; Provisional; Region: PRK09194 288705001538 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 288705001539 dimer interface [polypeptide binding]; other site 288705001540 motif 1; other site 288705001541 active site 288705001542 motif 2; other site 288705001543 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 288705001544 putative deacylase active site [active] 288705001545 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 288705001546 active site 288705001547 motif 3; other site 288705001548 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 288705001549 anticodon binding site; other site 288705001550 hypothetical protein; Provisional; Region: PRK10621 288705001551 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288705001552 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 288705001553 Sm and related proteins; Region: Sm_like; cl00259 288705001554 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 288705001555 putative oligomer interface [polypeptide binding]; other site 288705001556 putative RNA binding site [nucleotide binding]; other site 288705001557 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 288705001558 NusA N-terminal domain; Region: NusA_N; pfam08529 288705001559 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 288705001560 RNA binding site [nucleotide binding]; other site 288705001561 homodimer interface [polypeptide binding]; other site 288705001562 NusA-like KH domain; Region: KH_5; pfam13184 288705001563 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 288705001564 G-X-X-G motif; other site 288705001565 Protein of unknown function (DUF448); Region: DUF448; pfam04296 288705001566 putative RNA binding cleft [nucleotide binding]; other site 288705001567 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 288705001568 translation initiation factor IF-2; Region: IF-2; TIGR00487 288705001569 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 288705001570 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 288705001571 G1 box; other site 288705001572 putative GEF interaction site [polypeptide binding]; other site 288705001573 GTP/Mg2+ binding site [chemical binding]; other site 288705001574 Switch I region; other site 288705001575 G2 box; other site 288705001576 G3 box; other site 288705001577 Switch II region; other site 288705001578 G4 box; other site 288705001579 G5 box; other site 288705001580 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 288705001581 Translation-initiation factor 2; Region: IF-2; pfam11987 288705001582 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 288705001583 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 288705001584 aspartate aminotransferase; Provisional; Region: PRK05764 288705001585 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288705001586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705001587 homodimer interface [polypeptide binding]; other site 288705001588 catalytic residue [active] 288705001589 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 288705001590 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 288705001591 RNA binding site [nucleotide binding]; other site 288705001592 active site 288705001593 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 288705001594 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288705001595 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 288705001596 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 288705001597 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 288705001598 active site 288705001599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705001600 Transposase; Region: HTH_Tnp_1; cl17663 288705001601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 288705001602 HTH-like domain; Region: HTH_21; pfam13276 288705001603 Integrase core domain; Region: rve; pfam00665 288705001604 Integrase core domain; Region: rve_3; pfam13683 288705001605 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 288705001606 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 288705001607 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 288705001608 active site 288705001609 Riboflavin kinase; Region: Flavokinase; smart00904 288705001610 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 288705001611 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 288705001612 16S/18S rRNA binding site [nucleotide binding]; other site 288705001613 S13e-L30e interaction site [polypeptide binding]; other site 288705001614 25S rRNA binding site [nucleotide binding]; other site 288705001615 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 288705001616 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 288705001617 oligomer interface [polypeptide binding]; other site 288705001618 RNA binding site [nucleotide binding]; other site 288705001619 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 288705001620 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 288705001621 RNase E interface [polypeptide binding]; other site 288705001622 trimer interface [polypeptide binding]; other site 288705001623 active site 288705001624 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 288705001625 putative nucleic acid binding region [nucleotide binding]; other site 288705001626 G-X-X-G motif; other site 288705001627 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 288705001628 RNA binding site [nucleotide binding]; other site 288705001629 domain interface; other site 288705001630 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 288705001631 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 288705001632 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 288705001633 putative transposase OrfB; Reviewed; Region: PHA02517 288705001634 HTH-like domain; Region: HTH_21; pfam13276 288705001635 Integrase core domain; Region: rve; pfam00665 288705001636 Integrase core domain; Region: rve_3; pfam13683 288705001637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705001638 Transposase; Region: HTH_Tnp_1; cl17663 288705001639 Ubiquitin-like proteins; Region: UBQ; cl00155 288705001640 charged pocket; other site 288705001641 hydrophobic patch; other site 288705001642 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 288705001643 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288705001644 FeS/SAM binding site; other site 288705001645 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 288705001646 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 288705001647 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 288705001648 sulfate transport protein; Provisional; Region: cysT; CHL00187 288705001649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705001650 dimer interface [polypeptide binding]; other site 288705001651 conserved gate region; other site 288705001652 putative PBP binding loops; other site 288705001653 ABC-ATPase subunit interface; other site 288705001654 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 288705001655 Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174 288705001656 Moco binding site; other site 288705001657 metal coordination site [ion binding]; other site 288705001658 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 288705001659 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288705001660 active site 288705001661 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288705001662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705001663 active site 288705001664 phosphorylation site [posttranslational modification] 288705001665 intermolecular recognition site; other site 288705001666 dimerization interface [polypeptide binding]; other site 288705001667 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288705001668 DNA binding site [nucleotide binding] 288705001669 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288705001670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288705001671 dimer interface [polypeptide binding]; other site 288705001672 phosphorylation site [posttranslational modification] 288705001673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288705001674 ATP binding site [chemical binding]; other site 288705001675 Mg2+ binding site [ion binding]; other site 288705001676 G-X-G motif; other site 288705001677 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 288705001678 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 288705001679 Moco binding site; other site 288705001680 metal coordination site [ion binding]; other site 288705001681 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288705001682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705001683 NAD(P) binding site [chemical binding]; other site 288705001684 active site 288705001685 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 288705001686 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 288705001687 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 288705001688 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 288705001689 dimer interface [polypeptide binding]; other site 288705001690 putative functional site; other site 288705001691 putative MPT binding site; other site 288705001692 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 288705001693 trimer interface [polypeptide binding]; other site 288705001694 dimer interface [polypeptide binding]; other site 288705001695 putative active site [active] 288705001696 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 288705001697 MPT binding site; other site 288705001698 trimer interface [polypeptide binding]; other site 288705001699 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 288705001700 MoaE homodimer interface [polypeptide binding]; other site 288705001701 MoaD interaction [polypeptide binding]; other site 288705001702 active site residues [active] 288705001703 dihydrodipicolinate reductase; Provisional; Region: PRK00048 288705001704 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 288705001705 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 288705001706 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 288705001707 active site 288705001708 catalytic triad [active] 288705001709 oxyanion hole [active] 288705001710 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 288705001711 N-acetyl-D-glucosamine binding site [chemical binding]; other site 288705001712 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 288705001713 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 288705001714 dimer interface [polypeptide binding]; other site 288705001715 active site 288705001716 catalytic residue [active] 288705001717 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 288705001718 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288705001719 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 288705001720 Epoxide hydrolase N terminus; Region: EHN; pfam06441 288705001721 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288705001722 AzlC protein; Region: AzlC; pfam03591 288705001723 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288705001724 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288705001725 non-specific DNA binding site [nucleotide binding]; other site 288705001726 salt bridge; other site 288705001727 sequence-specific DNA binding site [nucleotide binding]; other site 288705001728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705001729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705001730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705001731 classical (c) SDRs; Region: SDR_c; cd05233 288705001732 NAD(P) binding site [chemical binding]; other site 288705001733 active site 288705001734 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 288705001735 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 288705001736 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 288705001737 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 288705001738 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 288705001739 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 288705001740 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 288705001741 human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c; cd05339 288705001742 putative NAD(P) binding site [chemical binding]; other site 288705001743 homodimer interface [polypeptide binding]; other site 288705001744 active site 288705001745 substrate binding site [chemical binding]; other site 288705001746 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 288705001747 Competence-damaged protein; Region: CinA; pfam02464 288705001748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288705001749 non-specific DNA binding site [nucleotide binding]; other site 288705001750 salt bridge; other site 288705001751 sequence-specific DNA binding site [nucleotide binding]; other site 288705001752 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288705001753 MarR family; Region: MarR; pfam01047 288705001754 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 288705001755 recombinase A; Provisional; Region: recA; PRK09354 288705001756 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 288705001757 hexamer interface [polypeptide binding]; other site 288705001758 Walker A motif; other site 288705001759 ATP binding site [chemical binding]; other site 288705001760 Walker B motif; other site 288705001761 recombination regulator RecX; Reviewed; Region: recX; PRK00117 288705001762 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 288705001763 N-acetyl-D-glucosamine binding site [chemical binding]; other site 288705001764 catalytic residue [active] 288705001765 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 288705001766 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 288705001767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288705001768 FeS/SAM binding site; other site 288705001769 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 288705001770 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 288705001771 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 288705001772 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 288705001773 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 288705001774 L-asparagine permease; Provisional; Region: PRK15049 288705001775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705001776 S-adenosylmethionine binding site [chemical binding]; other site 288705001777 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 288705001778 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 288705001779 HflX GTPase family; Region: HflX; cd01878 288705001780 G1 box; other site 288705001781 GTP/Mg2+ binding site [chemical binding]; other site 288705001782 Switch I region; other site 288705001783 G2 box; other site 288705001784 G3 box; other site 288705001785 Switch II region; other site 288705001786 G4 box; other site 288705001787 G5 box; other site 288705001788 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 288705001789 DEAD/DEAH box helicase; Region: DEAD; pfam00270 288705001790 ATP binding site [chemical binding]; other site 288705001791 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288705001792 putative Mg++ binding site [ion binding]; other site 288705001793 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 288705001794 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 288705001795 LexA repressor; Validated; Region: PRK00215 288705001796 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 288705001797 Catalytic site [active] 288705001798 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288705001799 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 288705001800 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288705001801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705001802 homodimer interface [polypeptide binding]; other site 288705001803 catalytic residue [active] 288705001804 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 288705001805 putative active site pocket [active] 288705001806 4-fold oligomerization interface [polypeptide binding]; other site 288705001807 metal binding residues [ion binding]; metal-binding site 288705001808 3-fold/trimer interface [polypeptide binding]; other site 288705001809 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 288705001810 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 288705001811 putative active site [active] 288705001812 oxyanion strand; other site 288705001813 catalytic triad [active] 288705001814 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 288705001815 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 288705001816 catalytic residues [active] 288705001817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705001818 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288705001819 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705001820 NAD(P) binding site [chemical binding]; other site 288705001821 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288705001822 active site 288705001823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705001824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705001825 translation initiation factor IF-3; Region: infC; TIGR00168 288705001826 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 288705001827 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 288705001828 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 288705001829 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 288705001830 23S rRNA binding site [nucleotide binding]; other site 288705001831 L21 binding site [polypeptide binding]; other site 288705001832 L13 binding site [polypeptide binding]; other site 288705001833 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 288705001834 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 288705001835 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 288705001836 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 288705001837 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288705001838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705001839 putative substrate translocation pore; other site 288705001840 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 288705001841 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 288705001842 dimer interface [polypeptide binding]; other site 288705001843 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288705001844 ligand binding site [chemical binding]; other site 288705001845 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 288705001846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 288705001847 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705001848 acyl-activating enzyme (AAE) consensus motif; other site 288705001849 CoA binding site [chemical binding]; other site 288705001850 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705001851 Transposase; Region: HTH_Tnp_1; cl17663 288705001852 putative transposase OrfB; Reviewed; Region: PHA02517 288705001853 HTH-like domain; Region: HTH_21; pfam13276 288705001854 Integrase core domain; Region: rve; pfam00665 288705001855 Integrase core domain; Region: rve_3; pfam13683 288705001856 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 288705001857 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 288705001858 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 288705001859 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 288705001860 dimer interface [polypeptide binding]; other site 288705001861 motif 1; other site 288705001862 active site 288705001863 motif 2; other site 288705001864 motif 3; other site 288705001865 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 288705001866 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 288705001867 putative tRNA-binding site [nucleotide binding]; other site 288705001868 B3/4 domain; Region: B3_4; pfam03483 288705001869 tRNA synthetase B5 domain; Region: B5; pfam03484 288705001870 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 288705001871 dimer interface [polypeptide binding]; other site 288705001872 motif 1; other site 288705001873 motif 3; other site 288705001874 motif 2; other site 288705001875 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 288705001876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705001877 Coenzyme A binding pocket [chemical binding]; other site 288705001878 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288705001879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705001880 putative substrate translocation pore; other site 288705001881 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288705001882 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288705001883 MarR family; Region: MarR_2; pfam12802 288705001884 MarR family; Region: MarR_2; cl17246 288705001885 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 288705001886 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 288705001887 Zn binding site [ion binding]; other site 288705001888 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 288705001889 putative acyl transferase; Provisional; Region: PRK10502 288705001890 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 288705001891 putative trimer interface [polypeptide binding]; other site 288705001892 putative CoA binding site [chemical binding]; other site 288705001893 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 288705001894 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705001895 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 288705001896 acyl-activating enzyme (AAE) consensus motif; other site 288705001897 AMP binding site [chemical binding]; other site 288705001898 active site 288705001899 CoA binding site [chemical binding]; other site 288705001900 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 288705001901 putative trimer interface [polypeptide binding]; other site 288705001902 putative CoA binding site [chemical binding]; other site 288705001903 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 288705001904 NAD(P) binding site [chemical binding]; other site 288705001905 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288705001906 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 288705001907 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 288705001908 putative hydrophobic ligand binding site [chemical binding]; other site 288705001909 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 288705001910 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 288705001911 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 288705001912 heterotetramer interface [polypeptide binding]; other site 288705001913 active site pocket [active] 288705001914 cleavage site 288705001915 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 288705001916 feedback inhibition sensing region; other site 288705001917 homohexameric interface [polypeptide binding]; other site 288705001918 nucleotide binding site [chemical binding]; other site 288705001919 N-acetyl-L-glutamate binding site [chemical binding]; other site 288705001920 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 288705001921 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288705001922 inhibitor-cofactor binding pocket; inhibition site 288705001923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705001924 catalytic residue [active] 288705001925 ornithine carbamoyltransferase; Provisional; Region: PRK00779 288705001926 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 288705001927 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 288705001928 arginine repressor; Provisional; Region: PRK03341 288705001929 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 288705001930 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 288705001931 argininosuccinate synthase; Provisional; Region: PRK13820 288705001932 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 288705001933 ANP binding site [chemical binding]; other site 288705001934 Substrate Binding Site II [chemical binding]; other site 288705001935 Substrate Binding Site I [chemical binding]; other site 288705001936 argininosuccinate lyase; Provisional; Region: PRK00855 288705001937 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 288705001938 active sites [active] 288705001939 tetramer interface [polypeptide binding]; other site 288705001940 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 288705001941 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 288705001942 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 288705001943 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 288705001944 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 288705001945 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288705001946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705001947 Walker A/P-loop; other site 288705001948 ATP binding site [chemical binding]; other site 288705001949 Q-loop/lid; other site 288705001950 ABC transporter signature motif; other site 288705001951 Walker B; other site 288705001952 D-loop; other site 288705001953 H-loop/switch region; other site 288705001954 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 288705001955 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 288705001956 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 288705001957 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 288705001958 DNA binding site [nucleotide binding] 288705001959 Bacterial transcriptional activator domain; Region: BTAD; smart01043 288705001960 Predicted ATPase [General function prediction only]; Region: COG3903 288705001961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705001962 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 288705001963 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 288705001964 DNA binding site [nucleotide binding] 288705001965 active site 288705001966 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288705001967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288705001968 AlkA N-terminal domain; Region: AlkA_N; pfam06029 288705001969 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 288705001970 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 288705001971 minor groove reading motif; other site 288705001972 helix-hairpin-helix signature motif; other site 288705001973 substrate binding pocket [chemical binding]; other site 288705001974 active site 288705001975 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 288705001976 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 288705001977 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 288705001978 NADH(P)-binding; Region: NAD_binding_10; pfam13460 288705001979 NAD(P) binding site [chemical binding]; other site 288705001980 putative active site [active] 288705001981 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 288705001982 active site 288705001983 DNA binding site [nucleotide binding] 288705001984 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288705001985 active site 288705001986 Part of AAA domain; Region: AAA_19; pfam13245 288705001987 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 288705001988 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 288705001989 active site 288705001990 HIGH motif; other site 288705001991 dimer interface [polypeptide binding]; other site 288705001992 KMSKS motif; other site 288705001993 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288705001994 RNA binding surface [nucleotide binding]; other site 288705001995 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 288705001996 hydrophobic ligand binding site; other site 288705001997 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 288705001998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288705001999 active site 288705002000 motif I; other site 288705002001 motif II; other site 288705002002 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 288705002003 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 288705002004 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288705002005 RNA binding surface [nucleotide binding]; other site 288705002006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705002007 S-adenosylmethionine binding site [chemical binding]; other site 288705002008 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 288705002009 ATP-NAD kinase; Region: NAD_kinase; pfam01513 288705002010 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 288705002011 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 288705002012 Walker A/P-loop; other site 288705002013 ATP binding site [chemical binding]; other site 288705002014 Q-loop/lid; other site 288705002015 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 288705002016 ABC transporter signature motif; other site 288705002017 Walker B; other site 288705002018 D-loop; other site 288705002019 H-loop/switch region; other site 288705002020 Chitin binding domain; Region: Chitin_bind_3; pfam03067 288705002021 CTP synthetase; Validated; Region: pyrG; PRK05380 288705002022 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 288705002023 Catalytic site [active] 288705002024 active site 288705002025 UTP binding site [chemical binding]; other site 288705002026 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 288705002027 active site 288705002028 putative oxyanion hole; other site 288705002029 catalytic triad [active] 288705002030 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 288705002031 dimer interface [polypeptide binding]; other site 288705002032 ADP-ribose binding site [chemical binding]; other site 288705002033 active site 288705002034 nudix motif; other site 288705002035 metal binding site [ion binding]; metal-binding site 288705002036 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 288705002037 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 288705002038 active site 288705002039 Int/Topo IB signature motif; other site 288705002040 FemAB family; Region: FemAB; pfam02388 288705002041 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 288705002042 nudix motif; other site 288705002043 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 288705002044 catalytic Zn binding site [ion binding]; other site 288705002045 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 288705002046 structural Zn binding site [ion binding]; other site 288705002047 tetramer interface [polypeptide binding]; other site 288705002048 citrate synthase; Provisional; Region: PRK14033 288705002049 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 288705002050 oxalacetate binding site [chemical binding]; other site 288705002051 citrylCoA binding site [chemical binding]; other site 288705002052 coenzyme A binding site [chemical binding]; other site 288705002053 catalytic triad [active] 288705002054 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 288705002055 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 288705002056 tetramer interface [polypeptide binding]; other site 288705002057 active site 288705002058 Mg2+/Mn2+ binding site [ion binding]; other site 288705002059 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 288705002060 Transcriptional regulators [Transcription]; Region: FadR; COG2186 288705002061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705002062 DNA-binding site [nucleotide binding]; DNA binding site 288705002063 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 288705002064 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 288705002065 homotrimer interaction site [polypeptide binding]; other site 288705002066 putative active site [active] 288705002067 Bacterial transcriptional regulator; Region: IclR; pfam01614 288705002068 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 288705002069 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288705002070 substrate binding site [chemical binding]; other site 288705002071 ATP binding site [chemical binding]; other site 288705002072 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 288705002073 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 288705002074 dimer interface [polypeptide binding]; other site 288705002075 active site 288705002076 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288705002077 substrate binding site [chemical binding]; other site 288705002078 catalytic residue [active] 288705002079 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 288705002080 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 288705002081 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 288705002082 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 288705002083 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 288705002084 active site 288705002085 intersubunit interface [polypeptide binding]; other site 288705002086 catalytic residue [active] 288705002087 fructuronate transporter; Provisional; Region: PRK10034; cl15264 288705002088 fructuronate transporter; Provisional; Region: PRK10034; cl15264 288705002089 HTH domain; Region: HTH_11; cl17392 288705002090 Transposase; Region: HTH_Tnp_1; cl17663 288705002091 putative transposase OrfB; Reviewed; Region: PHA02517 288705002092 HTH-like domain; Region: HTH_21; pfam13276 288705002093 Integrase core domain; Region: rve; pfam00665 288705002094 Integrase core domain; Region: rve_3; pfam13683 288705002095 amino acid transporter; Region: 2A0306; TIGR00909 288705002096 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 288705002097 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288705002098 Beta-lactamase; Region: Beta-lactamase; pfam00144 288705002099 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 288705002100 metal binding site 2 [ion binding]; metal-binding site 288705002101 putative DNA binding helix; other site 288705002102 metal binding site 1 [ion binding]; metal-binding site 288705002103 dimer interface [polypeptide binding]; other site 288705002104 structural Zn2+ binding site [ion binding]; other site 288705002105 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 288705002106 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 288705002107 tetramer interface [polypeptide binding]; other site 288705002108 heme binding pocket [chemical binding]; other site 288705002109 NADPH binding site [chemical binding]; other site 288705002110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705002111 putative substrate translocation pore; other site 288705002112 enterobactin exporter EntS; Provisional; Region: PRK10489 288705002113 enterobactin exporter EntS; Provisional; Region: PRK10489 288705002114 tetracycline repressor protein TetR; Provisional; Region: PRK13756 288705002115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705002116 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 288705002117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705002118 putative substrate translocation pore; other site 288705002119 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288705002120 catalytic core [active] 288705002121 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288705002122 Histidine kinase; Region: HisKA_3; pfam07730 288705002123 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 288705002124 ATP binding site [chemical binding]; other site 288705002125 Mg2+ binding site [ion binding]; other site 288705002126 G-X-G motif; other site 288705002127 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288705002128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705002129 active site 288705002130 phosphorylation site [posttranslational modification] 288705002131 intermolecular recognition site; other site 288705002132 dimerization interface [polypeptide binding]; other site 288705002133 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288705002134 DNA binding residues [nucleotide binding] 288705002135 dimerization interface [polypeptide binding]; other site 288705002136 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 288705002137 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 288705002138 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288705002139 Acyltransferase family; Region: Acyl_transf_3; pfam01757 288705002140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 288705002141 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 288705002142 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288705002143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288705002144 NlpC/P60 family; Region: NLPC_P60; cl17555 288705002145 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 288705002146 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 288705002147 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 288705002148 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 288705002149 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 288705002150 active site 288705002151 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288705002152 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 288705002153 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 288705002154 Predicted amidohydrolase [General function prediction only]; Region: COG0388 288705002155 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 288705002156 active site 288705002157 catalytic triad [active] 288705002158 dimer interface [polypeptide binding]; other site 288705002159 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 288705002160 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 288705002161 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 288705002162 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 288705002163 ATP-grasp domain; Region: ATP-grasp_4; cl17255 288705002164 alanine racemase; Reviewed; Region: alr; PRK00053 288705002165 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 288705002166 active site 288705002167 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288705002168 dimer interface [polypeptide binding]; other site 288705002169 substrate binding site [chemical binding]; other site 288705002170 catalytic residues [active] 288705002171 MarR family; Region: MarR; pfam01047 288705002172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705002173 putative substrate translocation pore; other site 288705002174 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288705002175 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288705002176 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288705002177 Walker A/P-loop; other site 288705002178 ATP binding site [chemical binding]; other site 288705002179 Q-loop/lid; other site 288705002180 ABC transporter signature motif; other site 288705002181 Walker B; other site 288705002182 D-loop; other site 288705002183 H-loop/switch region; other site 288705002184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705002185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705002186 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 288705002187 MgtC family; Region: MgtC; pfam02308 288705002188 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288705002189 catalytic residues [active] 288705002190 Uncharacterized conserved protein [Function unknown]; Region: COG1359 288705002191 Protein of unknown function (DUF952); Region: DUF952; cl01393 288705002192 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 288705002193 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 288705002194 minor groove reading motif; other site 288705002195 helix-hairpin-helix signature motif; other site 288705002196 substrate binding pocket [chemical binding]; other site 288705002197 active site 288705002198 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 288705002199 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 288705002200 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 288705002201 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 288705002202 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 288705002203 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 288705002204 metal binding site [ion binding]; metal-binding site 288705002205 dimer interface [polypeptide binding]; other site 288705002206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 288705002207 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 288705002208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288705002209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288705002210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288705002211 dimerization interface [polypeptide binding]; other site 288705002212 EamA-like transporter family; Region: EamA; pfam00892 288705002213 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288705002214 EamA-like transporter family; Region: EamA; pfam00892 288705002215 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 288705002216 Fatty acid desaturase; Region: FA_desaturase; pfam00487 288705002217 Di-iron ligands [ion binding]; other site 288705002218 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 288705002219 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 288705002220 dimer interface [polypeptide binding]; other site 288705002221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705002222 catalytic residue [active] 288705002223 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 288705002224 cystathionine gamma-synthase; Provisional; Region: PRK07811 288705002225 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 288705002226 homodimer interface [polypeptide binding]; other site 288705002227 substrate-cofactor binding pocket; other site 288705002228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705002229 catalytic residue [active] 288705002230 Trypsin; Region: Trypsin; pfam00089 288705002231 cleavage site 288705002232 active site 288705002233 substrate binding sites [chemical binding]; other site 288705002234 Trypsin; Region: Trypsin; pfam00089 288705002235 cleavage site 288705002236 active site 288705002237 substrate binding sites [chemical binding]; other site 288705002238 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288705002239 cleavage site 288705002240 active site 288705002241 substrate binding sites [chemical binding]; other site 288705002242 acyl-coenzyme A oxidase; Region: PLN02526 288705002243 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705002244 active site 288705002245 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 288705002246 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 288705002247 active site 288705002248 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 288705002249 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 288705002250 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288705002251 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288705002252 DNA binding site [nucleotide binding] 288705002253 domain linker motif; other site 288705002254 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288705002255 dimerization interface [polypeptide binding]; other site 288705002256 ligand binding site [chemical binding]; other site 288705002257 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288705002258 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288705002259 nucleotide binding site [chemical binding]; other site 288705002260 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 288705002261 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 288705002262 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 288705002263 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 288705002264 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288705002265 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 288705002266 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288705002267 K+-transporting ATPase, c chain; Region: KdpC; cl00944 288705002268 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 288705002269 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 288705002270 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 288705002271 Ligand Binding Site [chemical binding]; other site 288705002272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288705002273 dimer interface [polypeptide binding]; other site 288705002274 phosphorylation site [posttranslational modification] 288705002275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288705002276 ATP binding site [chemical binding]; other site 288705002277 Mg2+ binding site [ion binding]; other site 288705002278 G-X-G motif; other site 288705002279 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 288705002280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705002281 active site 288705002282 phosphorylation site [posttranslational modification] 288705002283 intermolecular recognition site; other site 288705002284 dimerization interface [polypeptide binding]; other site 288705002285 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288705002286 DNA binding site [nucleotide binding] 288705002287 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705002288 dimerization interface [polypeptide binding]; other site 288705002289 putative DNA binding site [nucleotide binding]; other site 288705002290 putative Zn2+ binding site [ion binding]; other site 288705002291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705002292 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288705002293 putative substrate translocation pore; other site 288705002294 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 288705002295 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288705002296 Beta-lactamase; Region: Beta-lactamase; pfam00144 288705002297 Beta-lactamase; Region: Beta-lactamase; pfam00144 288705002298 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288705002299 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 288705002300 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 288705002301 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 288705002302 ATP binding site [chemical binding]; other site 288705002303 Mg++ binding site [ion binding]; other site 288705002304 motif III; other site 288705002305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705002306 nucleotide binding region [chemical binding]; other site 288705002307 ATP-binding site [chemical binding]; other site 288705002308 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 288705002309 putative RNA binding site [nucleotide binding]; other site 288705002310 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288705002311 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 288705002312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705002313 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288705002314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705002315 NAD(P) binding site [chemical binding]; other site 288705002316 active site 288705002317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705002318 Secretory lipase; Region: LIP; pfam03583 288705002319 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 288705002320 active site 288705002321 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 288705002322 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288705002323 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 288705002324 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 288705002325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705002326 putative substrate translocation pore; other site 288705002327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705002328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705002329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705002330 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 288705002331 active site 288705002332 catalytic site [active] 288705002333 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 288705002334 active site 288705002335 catalytic site [active] 288705002336 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 288705002337 FAD binding domain; Region: FAD_binding_4; pfam01565 288705002338 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 288705002339 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 288705002340 Leucine carboxyl methyltransferase; Region: LCM; cl01306 288705002341 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288705002342 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288705002343 Walker A/P-loop; other site 288705002344 ATP binding site [chemical binding]; other site 288705002345 Q-loop/lid; other site 288705002346 ABC transporter signature motif; other site 288705002347 Walker B; other site 288705002348 D-loop; other site 288705002349 H-loop/switch region; other site 288705002350 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 288705002351 putative FMN binding site [chemical binding]; other site 288705002352 NADPH bind site [chemical binding]; other site 288705002353 putative transposase OrfB; Reviewed; Region: PHA02517 288705002354 HTH-like domain; Region: HTH_21; pfam13276 288705002355 Integrase core domain; Region: rve; pfam00665 288705002356 Integrase core domain; Region: rve_3; pfam13683 288705002357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705002358 Transposase; Region: HTH_Tnp_1; cl17663 288705002359 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 288705002360 Fatty acid desaturase; Region: FA_desaturase; pfam00487 288705002361 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 288705002362 putative di-iron ligands [ion binding]; other site 288705002363 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 288705002364 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 288705002365 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 288705002366 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 288705002367 folate binding site [chemical binding]; other site 288705002368 NADP+ binding site [chemical binding]; other site 288705002369 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 288705002370 thymidylate synthase; Reviewed; Region: thyA; PRK01827 288705002371 active site 288705002372 dimerization interface [polypeptide binding]; other site 288705002373 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 288705002374 Predicted membrane protein [General function prediction only]; Region: COG4194 288705002375 Predicted transcriptional regulators [Transcription]; Region: COG1725 288705002376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705002377 DNA-binding site [nucleotide binding]; DNA binding site 288705002378 Poly(A) polymerase [RNA processing and modification]; Region: PAP1; COG5186 288705002379 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 288705002380 active site 288705002381 Ap6A binding site [chemical binding]; other site 288705002382 nudix motif; other site 288705002383 metal binding site [ion binding]; metal-binding site 288705002384 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288705002385 catalytic core [active] 288705002386 polyphosphate kinase; Provisional; Region: PRK05443 288705002387 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 288705002388 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 288705002389 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 288705002390 putative domain interface [polypeptide binding]; other site 288705002391 putative active site [active] 288705002392 catalytic site [active] 288705002393 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 288705002394 putative domain interface [polypeptide binding]; other site 288705002395 putative active site [active] 288705002396 catalytic site [active] 288705002397 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 288705002398 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288705002399 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288705002400 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 288705002401 DNA binding site [nucleotide binding] 288705002402 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288705002403 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 288705002404 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 288705002405 heme-binding site [chemical binding]; other site 288705002406 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 288705002407 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 288705002408 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 288705002409 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288705002410 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 288705002411 phosphofructokinase; Region: PFK_mixed; TIGR02483 288705002412 active site 288705002413 ADP/pyrophosphate binding site [chemical binding]; other site 288705002414 dimerization interface [polypeptide binding]; other site 288705002415 allosteric effector site; other site 288705002416 fructose-1,6-bisphosphate binding site; other site 288705002417 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 288705002418 amphipathic channel; other site 288705002419 Asn-Pro-Ala signature motifs; other site 288705002420 PspC domain; Region: PspC; pfam04024 288705002421 PspC domain; Region: PspC; pfam04024 288705002422 PspC domain; Region: PspC; pfam04024 288705002423 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288705002424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705002425 active site 288705002426 phosphorylation site [posttranslational modification] 288705002427 intermolecular recognition site; other site 288705002428 dimerization interface [polypeptide binding]; other site 288705002429 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288705002430 DNA binding residues [nucleotide binding] 288705002431 dimerization interface [polypeptide binding]; other site 288705002432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705002433 Transposase; Region: HTH_Tnp_1; pfam01527 288705002434 putative transposase OrfB; Reviewed; Region: PHA02517 288705002435 HTH-like domain; Region: HTH_21; pfam13276 288705002436 Integrase core domain; Region: rve; pfam00665 288705002437 Integrase core domain; Region: rve_3; pfam13683 288705002438 putative transposase OrfB; Reviewed; Region: PHA02517 288705002439 HTH-like domain; Region: HTH_21; pfam13276 288705002440 Integrase core domain; Region: rve; pfam00665 288705002441 Integrase core domain; Region: rve_3; pfam13683 288705002442 aspartate aminotransferase; Provisional; Region: PRK05764 288705002443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288705002444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705002445 homodimer interface [polypeptide binding]; other site 288705002446 catalytic residue [active] 288705002447 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 288705002448 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 288705002449 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 288705002450 putative homodimer interface [polypeptide binding]; other site 288705002451 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 288705002452 heterodimer interface [polypeptide binding]; other site 288705002453 homodimer interface [polypeptide binding]; other site 288705002454 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 288705002455 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 288705002456 23S rRNA interface [nucleotide binding]; other site 288705002457 putative thiostrepton binding site; other site 288705002458 L7/L12 interface [polypeptide binding]; other site 288705002459 L25 interface [polypeptide binding]; other site 288705002460 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 288705002461 mRNA/rRNA interface [nucleotide binding]; other site 288705002462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705002463 Coenzyme A binding pocket [chemical binding]; other site 288705002464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288705002465 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705002466 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288705002467 Coenzyme A binding pocket [chemical binding]; other site 288705002468 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288705002469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705002470 Coenzyme A binding pocket [chemical binding]; other site 288705002471 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 288705002472 23S rRNA interface [nucleotide binding]; other site 288705002473 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 288705002474 core dimer interface [polypeptide binding]; other site 288705002475 peripheral dimer interface [polypeptide binding]; other site 288705002476 L10 interface [polypeptide binding]; other site 288705002477 L11 interface [polypeptide binding]; other site 288705002478 putative EF-Tu interaction site [polypeptide binding]; other site 288705002479 putative EF-G interaction site [polypeptide binding]; other site 288705002480 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 288705002481 putative active site [active] 288705002482 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705002483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705002484 dimer interface [polypeptide binding]; other site 288705002485 conserved gate region; other site 288705002486 putative PBP binding loops; other site 288705002487 ABC-ATPase subunit interface; other site 288705002488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705002489 dimer interface [polypeptide binding]; other site 288705002490 ABC-ATPase subunit interface; other site 288705002491 putative PBP binding loops; other site 288705002492 putative transposase OrfB; Reviewed; Region: PHA02517 288705002493 HTH-like domain; Region: HTH_21; pfam13276 288705002494 Integrase core domain; Region: rve; pfam00665 288705002495 Integrase core domain; Region: rve_3; pfam13683 288705002496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705002497 Transposase; Region: HTH_Tnp_1; cl17663 288705002498 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 288705002499 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 288705002500 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 288705002501 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 288705002502 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288705002503 Walker A/P-loop; other site 288705002504 ATP binding site [chemical binding]; other site 288705002505 Q-loop/lid; other site 288705002506 ABC transporter signature motif; other site 288705002507 Walker B; other site 288705002508 D-loop; other site 288705002509 H-loop/switch region; other site 288705002510 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 288705002511 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 288705002512 Walker A/P-loop; other site 288705002513 ATP binding site [chemical binding]; other site 288705002514 Q-loop/lid; other site 288705002515 ABC transporter signature motif; other site 288705002516 Walker B; other site 288705002517 D-loop; other site 288705002518 H-loop/switch region; other site 288705002519 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 288705002520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288705002521 non-specific DNA binding site [nucleotide binding]; other site 288705002522 salt bridge; other site 288705002523 sequence-specific DNA binding site [nucleotide binding]; other site 288705002524 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 288705002525 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 288705002526 putative active site [active] 288705002527 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 288705002528 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 288705002529 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705002530 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705002531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705002532 catalytic residue [active] 288705002533 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 288705002534 active site residue [active] 288705002535 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705002536 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 288705002537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705002538 Walker A/P-loop; other site 288705002539 ATP binding site [chemical binding]; other site 288705002540 Q-loop/lid; other site 288705002541 ABC transporter signature motif; other site 288705002542 Walker B; other site 288705002543 D-loop; other site 288705002544 H-loop/switch region; other site 288705002545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705002546 dimer interface [polypeptide binding]; other site 288705002547 putative PBP binding loops; other site 288705002548 ABC-ATPase subunit interface; other site 288705002549 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705002550 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 288705002551 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705002552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705002553 dimer interface [polypeptide binding]; other site 288705002554 conserved gate region; other site 288705002555 putative PBP binding loops; other site 288705002556 ABC-ATPase subunit interface; other site 288705002557 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 288705002558 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288705002559 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 288705002560 FAD binding pocket [chemical binding]; other site 288705002561 FAD binding motif [chemical binding]; other site 288705002562 phosphate binding motif [ion binding]; other site 288705002563 NAD binding pocket [chemical binding]; other site 288705002564 Siderophore-interacting protein; Region: SIP; pfam04954 288705002565 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288705002566 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 288705002567 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 288705002568 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 288705002569 homodimer interface [polypeptide binding]; other site 288705002570 substrate-cofactor binding pocket; other site 288705002571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705002572 catalytic residue [active] 288705002573 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 288705002574 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 288705002575 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 288705002576 hypothetical protein; Provisional; Region: PRK06547 288705002577 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 288705002578 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 288705002579 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 288705002580 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 288705002581 Low molecular weight phosphatase family; Region: LMWPc; cd00115 288705002582 active site 288705002583 Integrase core domain; Region: rve_3; pfam13683 288705002584 HTH-like domain; Region: HTH_21; pfam13276 288705002585 Integrase core domain; Region: rve; pfam00665 288705002586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705002587 Transposase; Region: HTH_Tnp_1; cl17663 288705002588 threonyl-tRNA synthetase; Validated; Region: PRK03991 288705002589 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 288705002590 active site 288705002591 catalytic triad [active] 288705002592 oxyanion hole [active] 288705002593 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 288705002594 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 288705002595 catalytic triad [active] 288705002596 MarR family; Region: MarR; pfam01047 288705002597 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288705002598 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288705002599 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288705002600 cleavage site 288705002601 active site 288705002602 substrate binding sites [chemical binding]; other site 288705002603 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288705002604 cleavage site 288705002605 active site 288705002606 substrate binding sites [chemical binding]; other site 288705002607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 288705002608 active site 288705002609 motif I; other site 288705002610 motif II; other site 288705002611 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 288705002612 putative ligand binding site [chemical binding]; other site 288705002613 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 288705002614 putative NAD binding site [chemical binding]; other site 288705002615 catalytic site [active] 288705002616 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 288705002617 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 288705002618 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288705002619 PYR/PP interface [polypeptide binding]; other site 288705002620 dimer interface [polypeptide binding]; other site 288705002621 TPP binding site [chemical binding]; other site 288705002622 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 288705002623 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 288705002624 TPP-binding site [chemical binding]; other site 288705002625 dimer interface [polypeptide binding]; other site 288705002626 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 288705002627 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 288705002628 putative valine binding site [chemical binding]; other site 288705002629 dimer interface [polypeptide binding]; other site 288705002630 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 288705002631 ketol-acid reductoisomerase; Provisional; Region: PRK05479 288705002632 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 288705002633 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 288705002634 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 288705002635 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 288705002636 ligand binding site [chemical binding]; other site 288705002637 NAD binding site [chemical binding]; other site 288705002638 dimerization interface [polypeptide binding]; other site 288705002639 catalytic site [active] 288705002640 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 288705002641 putative L-serine binding site [chemical binding]; other site 288705002642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705002643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 288705002644 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705002645 dimerization interface [polypeptide binding]; other site 288705002646 putative DNA binding site [nucleotide binding]; other site 288705002647 putative Zn2+ binding site [ion binding]; other site 288705002648 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 288705002649 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 288705002650 active site 288705002651 HIGH motif; other site 288705002652 KMSKS motif; other site 288705002653 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 288705002654 tRNA binding surface [nucleotide binding]; other site 288705002655 anticodon binding site; other site 288705002656 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288705002657 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288705002658 FtsX-like permease family; Region: FtsX; pfam02687 288705002659 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288705002660 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288705002661 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288705002662 Walker A/P-loop; other site 288705002663 ATP binding site [chemical binding]; other site 288705002664 Q-loop/lid; other site 288705002665 ABC transporter signature motif; other site 288705002666 Walker B; other site 288705002667 D-loop; other site 288705002668 H-loop/switch region; other site 288705002669 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288705002670 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288705002671 DNA binding residues [nucleotide binding] 288705002672 dimerization interface [polypeptide binding]; other site 288705002673 Response regulator receiver domain; Region: Response_reg; pfam00072 288705002674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705002675 active site 288705002676 phosphorylation site [posttranslational modification] 288705002677 intermolecular recognition site; other site 288705002678 dimerization interface [polypeptide binding]; other site 288705002679 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288705002680 Histidine kinase; Region: HisKA_3; pfam07730 288705002681 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 288705002682 tartrate dehydrogenase; Region: TTC; TIGR02089 288705002683 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 288705002684 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 288705002685 homodimer interface [polypeptide binding]; other site 288705002686 substrate-cofactor binding pocket; other site 288705002687 catalytic residue [active] 288705002688 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 288705002689 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 288705002690 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 288705002691 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 288705002692 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 288705002693 HIGH motif; other site 288705002694 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 288705002695 active site 288705002696 KMSKS motif; other site 288705002697 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 288705002698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288705002699 active site 288705002700 motif I; other site 288705002701 motif II; other site 288705002702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705002703 Transposase; Region: HTH_Tnp_1; cl17663 288705002704 putative transposase OrfB; Reviewed; Region: PHA02517 288705002705 HTH-like domain; Region: HTH_21; pfam13276 288705002706 Integrase core domain; Region: rve; pfam00665 288705002707 Integrase core domain; Region: rve_3; pfam13683 288705002708 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 288705002709 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 288705002710 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 288705002711 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 288705002712 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 288705002713 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 288705002714 Nitrogen regulatory protein P-II; Region: P-II; smart00938 288705002715 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 288705002716 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 288705002717 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 288705002718 signal recognition particle protein; Provisional; Region: PRK10867 288705002719 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 288705002720 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 288705002721 P loop; other site 288705002722 GTP binding site [chemical binding]; other site 288705002723 Signal peptide binding domain; Region: SRP_SPB; pfam02978 288705002724 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288705002725 ThiC-associated domain; Region: ThiC-associated; pfam13667 288705002726 ThiC family; Region: ThiC; cl08031 288705002727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705002728 Coenzyme A binding pocket [chemical binding]; other site 288705002729 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 288705002730 hypothetical protein; Provisional; Region: PRK02821 288705002731 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 288705002732 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 288705002733 RimM N-terminal domain; Region: RimM; pfam01782 288705002734 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 288705002735 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 288705002736 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288705002737 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288705002738 Catalytic site [active] 288705002739 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288705002740 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288705002741 Catalytic site [active] 288705002742 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 288705002743 RNA/DNA hybrid binding site [nucleotide binding]; other site 288705002744 active site 288705002745 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 288705002746 hypothetical protein; Reviewed; Region: PRK12497 288705002747 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 288705002748 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 288705002749 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 288705002750 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 288705002751 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 288705002752 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 288705002753 putative transposase OrfB; Reviewed; Region: PHA02517 288705002754 HTH-like domain; Region: HTH_21; pfam13276 288705002755 Integrase core domain; Region: rve; pfam00665 288705002756 Integrase core domain; Region: rve_3; pfam13683 288705002757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705002758 Transposase; Region: HTH_Tnp_1; cl17663 288705002759 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 288705002760 DNA protecting protein DprA; Region: dprA; TIGR00732 288705002761 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 288705002762 RibD C-terminal domain; Region: RibD_C; cl17279 288705002763 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 288705002764 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288705002765 active site 288705002766 DNA binding site [nucleotide binding] 288705002767 Int/Topo IB signature motif; other site 288705002768 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 288705002769 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 288705002770 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 288705002771 dimer interface [polypeptide binding]; other site 288705002772 active site 288705002773 acyl carrier protein; Provisional; Region: acpP; PRK00982 288705002774 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 288705002775 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 288705002776 dimer interface [polypeptide binding]; other site 288705002777 active site 288705002778 CoA binding pocket [chemical binding]; other site 288705002779 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 288705002780 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 288705002781 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 288705002782 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 288705002783 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 288705002784 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 288705002785 dimer interface [polypeptide binding]; other site 288705002786 TPP-binding site [chemical binding]; other site 288705002787 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 288705002788 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 288705002789 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 288705002790 dimer interface [polypeptide binding]; other site 288705002791 catalytic triad [active] 288705002792 putative transposase OrfB; Reviewed; Region: PHA02517 288705002793 HTH-like domain; Region: HTH_21; pfam13276 288705002794 Integrase core domain; Region: rve; pfam00665 288705002795 Integrase core domain; Region: rve_3; pfam13683 288705002796 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 288705002797 ATP binding site [chemical binding]; other site 288705002798 Walker A motif; other site 288705002799 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 288705002800 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 288705002801 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 288705002802 AAA domain; Region: AAA_30; pfam13604 288705002803 IPT/TIG domain; Region: TIG; pfam01833 288705002804 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 288705002805 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 288705002806 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 288705002807 DNA-binding interface [nucleotide binding]; DNA binding site 288705002808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705002809 Transposase; Region: HTH_Tnp_1; cl17663 288705002810 putative transposase OrfB; Reviewed; Region: PHA02517 288705002811 HTH-like domain; Region: HTH_21; pfam13276 288705002812 Integrase core domain; Region: rve; pfam00665 288705002813 Integrase core domain; Region: rve_3; pfam13683 288705002814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705002815 NAD(P) binding site [chemical binding]; other site 288705002816 active site 288705002817 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 288705002818 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 288705002819 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288705002820 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288705002821 active site 288705002822 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288705002823 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288705002824 active site 288705002825 catalytic tetrad [active] 288705002826 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 288705002827 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 288705002828 oligomer interface [polypeptide binding]; other site 288705002829 metal binding site [ion binding]; metal-binding site 288705002830 metal binding site [ion binding]; metal-binding site 288705002831 putative Cl binding site [ion binding]; other site 288705002832 basic sphincter; other site 288705002833 hydrophobic gate; other site 288705002834 periplasmic entrance; other site 288705002835 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 288705002836 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 288705002837 AsnC family; Region: AsnC_trans_reg; pfam01037 288705002838 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705002839 dimerization interface [polypeptide binding]; other site 288705002840 putative DNA binding site [nucleotide binding]; other site 288705002841 putative Zn2+ binding site [ion binding]; other site 288705002842 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 288705002843 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 288705002844 putative DNA binding site [nucleotide binding]; other site 288705002845 putative Zn2+ binding site [ion binding]; other site 288705002846 AsnC family; Region: AsnC_trans_reg; pfam01037 288705002847 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 288705002848 FMN binding site [chemical binding]; other site 288705002849 substrate binding site [chemical binding]; other site 288705002850 putative catalytic residue [active] 288705002851 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 288705002852 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 288705002853 Pirin-related protein [General function prediction only]; Region: COG1741 288705002854 Pirin; Region: Pirin; pfam02678 288705002855 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 288705002856 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 288705002857 nudix motif; other site 288705002858 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288705002859 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 288705002860 GTP/Mg2+ binding site [chemical binding]; other site 288705002861 G4 box; other site 288705002862 G5 box; other site 288705002863 G1 box; other site 288705002864 Switch I region; other site 288705002865 G2 box; other site 288705002866 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288705002867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705002868 Walker A/P-loop; other site 288705002869 ATP binding site [chemical binding]; other site 288705002870 Q-loop/lid; other site 288705002871 ABC transporter signature motif; other site 288705002872 Walker B; other site 288705002873 D-loop; other site 288705002874 H-loop/switch region; other site 288705002875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705002876 dimer interface [polypeptide binding]; other site 288705002877 conserved gate region; other site 288705002878 ABC-ATPase subunit interface; other site 288705002879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705002880 dimer interface [polypeptide binding]; other site 288705002881 conserved gate region; other site 288705002882 putative PBP binding loops; other site 288705002883 ABC-ATPase subunit interface; other site 288705002884 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 288705002885 aminotransferase AlaT; Validated; Region: PRK09265 288705002886 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288705002887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705002888 homodimer interface [polypeptide binding]; other site 288705002889 catalytic residue [active] 288705002890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705002891 Transposase; Region: HTH_Tnp_1; cl17663 288705002892 putative transposase OrfB; Reviewed; Region: PHA02517 288705002893 HTH-like domain; Region: HTH_21; pfam13276 288705002894 Integrase core domain; Region: rve; pfam00665 288705002895 Integrase core domain; Region: rve_3; pfam13683 288705002896 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 288705002897 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 288705002898 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 288705002899 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 288705002900 generic binding surface II; other site 288705002901 generic binding surface I; other site 288705002902 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 288705002903 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 288705002904 RmuC family; Region: RmuC; pfam02646 288705002905 GTP-binding protein YchF; Reviewed; Region: PRK09601 288705002906 YchF GTPase; Region: YchF; cd01900 288705002907 G1 box; other site 288705002908 GTP/Mg2+ binding site [chemical binding]; other site 288705002909 Switch I region; other site 288705002910 G2 box; other site 288705002911 Switch II region; other site 288705002912 G3 box; other site 288705002913 G4 box; other site 288705002914 G5 box; other site 288705002915 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 288705002916 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 288705002917 putative dimer interface [polypeptide binding]; other site 288705002918 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288705002919 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 288705002920 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 288705002921 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 288705002922 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288705002923 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288705002924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705002925 ABC-ATPase subunit interface; other site 288705002926 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288705002927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705002928 dimer interface [polypeptide binding]; other site 288705002929 conserved gate region; other site 288705002930 putative PBP binding loops; other site 288705002931 ABC-ATPase subunit interface; other site 288705002932 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 288705002933 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 288705002934 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288705002935 Walker A/P-loop; other site 288705002936 ATP binding site [chemical binding]; other site 288705002937 Q-loop/lid; other site 288705002938 ABC transporter signature motif; other site 288705002939 Walker B; other site 288705002940 D-loop; other site 288705002941 H-loop/switch region; other site 288705002942 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 288705002943 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288705002944 Walker A/P-loop; other site 288705002945 ATP binding site [chemical binding]; other site 288705002946 Q-loop/lid; other site 288705002947 ABC transporter signature motif; other site 288705002948 Walker B; other site 288705002949 D-loop; other site 288705002950 H-loop/switch region; other site 288705002951 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288705002952 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 288705002953 active site 288705002954 catalytic triad [active] 288705002955 oxyanion hole [active] 288705002956 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 288705002957 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 288705002958 G1 box; other site 288705002959 putative GEF interaction site [polypeptide binding]; other site 288705002960 GTP/Mg2+ binding site [chemical binding]; other site 288705002961 Switch I region; other site 288705002962 G2 box; other site 288705002963 G3 box; other site 288705002964 Switch II region; other site 288705002965 G4 box; other site 288705002966 G5 box; other site 288705002967 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 288705002968 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 288705002969 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 288705002970 H+ Antiporter protein; Region: 2A0121; TIGR00900 288705002971 H+ Antiporter protein; Region: 2A0121; TIGR00900 288705002972 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 288705002973 dimer interface [polypeptide binding]; other site 288705002974 substrate binding site [chemical binding]; other site 288705002975 ATP binding site [chemical binding]; other site 288705002976 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 288705002977 4Fe-4S binding domain; Region: Fer4; pfam00037 288705002978 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 288705002979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288705002980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705002981 homodimer interface [polypeptide binding]; other site 288705002982 catalytic residue [active] 288705002983 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 288705002984 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 288705002985 dimer interface [polypeptide binding]; other site 288705002986 active site 288705002987 citrylCoA binding site [chemical binding]; other site 288705002988 NADH binding [chemical binding]; other site 288705002989 cationic pore residues; other site 288705002990 oxalacetate/citrate binding site [chemical binding]; other site 288705002991 coenzyme A binding site [chemical binding]; other site 288705002992 catalytic triad [active] 288705002993 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 288705002994 UDP-glucose 4-epimerase; Region: PLN02240 288705002995 NAD binding site [chemical binding]; other site 288705002996 homodimer interface [polypeptide binding]; other site 288705002997 active site 288705002998 substrate binding site [chemical binding]; other site 288705002999 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 288705003000 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 288705003001 putative trimer interface [polypeptide binding]; other site 288705003002 putative CoA binding site [chemical binding]; other site 288705003003 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 288705003004 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 288705003005 metal binding site [ion binding]; metal-binding site 288705003006 putative dimer interface [polypeptide binding]; other site 288705003007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705003008 dimer interface [polypeptide binding]; other site 288705003009 conserved gate region; other site 288705003010 putative PBP binding loops; other site 288705003011 ABC-ATPase subunit interface; other site 288705003012 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 288705003013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705003014 dimer interface [polypeptide binding]; other site 288705003015 conserved gate region; other site 288705003016 putative PBP binding loops; other site 288705003017 ABC-ATPase subunit interface; other site 288705003018 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 288705003019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288705003020 substrate binding pocket [chemical binding]; other site 288705003021 membrane-bound complex binding site; other site 288705003022 hinge residues; other site 288705003023 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288705003024 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 288705003025 Walker A/P-loop; other site 288705003026 ATP binding site [chemical binding]; other site 288705003027 Q-loop/lid; other site 288705003028 ABC transporter signature motif; other site 288705003029 Walker B; other site 288705003030 D-loop; other site 288705003031 H-loop/switch region; other site 288705003032 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 288705003033 DivIVA domain; Region: DivI1A_domain; TIGR03544 288705003034 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 288705003035 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 288705003036 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 288705003037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705003038 S-adenosylmethionine binding site [chemical binding]; other site 288705003039 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 288705003040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288705003041 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288705003042 DNA binding residues [nucleotide binding] 288705003043 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 288705003044 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 288705003045 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 288705003046 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 288705003047 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 288705003048 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 288705003049 MgtE intracellular N domain; Region: MgtE_N; smart00924 288705003050 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 288705003051 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 288705003052 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 288705003053 active site 288705003054 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 288705003055 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 288705003056 active site 288705003057 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 288705003058 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 288705003059 DNA methylase; Region: N6_N4_Mtase; pfam01555 288705003060 helicase 45; Provisional; Region: PTZ00424 288705003061 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 288705003062 ATP binding site [chemical binding]; other site 288705003063 Mg++ binding site [ion binding]; other site 288705003064 motif III; other site 288705003065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705003066 nucleotide binding region [chemical binding]; other site 288705003067 ATP-binding site [chemical binding]; other site 288705003068 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 288705003069 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 288705003070 RNB domain; Region: RNB; pfam00773 288705003071 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 288705003072 dinuclear metal binding motif [ion binding]; other site 288705003073 Thiamine monophosphate synthase/TENI; Region: TMP-TENI; cl17228 288705003074 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 288705003075 thiamine phosphate binding site [chemical binding]; other site 288705003076 active site 288705003077 pyrophosphate binding site [ion binding]; other site 288705003078 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 288705003079 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 288705003080 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 288705003081 thiS-thiF/thiG interaction site; other site 288705003082 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 288705003083 ThiS interaction site; other site 288705003084 putative active site [active] 288705003085 tetramer interface [polypeptide binding]; other site 288705003086 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 288705003087 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705003088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705003089 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 288705003090 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 288705003091 ATP binding site [chemical binding]; other site 288705003092 substrate interface [chemical binding]; other site 288705003093 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288705003094 active site residue [active] 288705003095 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 288705003096 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 288705003097 NAD(P) binding pocket [chemical binding]; other site 288705003098 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 288705003099 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 288705003100 substrate binding site [chemical binding]; other site 288705003101 active site 288705003102 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 288705003103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288705003104 Chlorite dismutase; Region: Chlor_dismutase; cl01280 288705003105 ferrochelatase; Reviewed; Region: hemH; PRK00035 288705003106 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 288705003107 C-terminal domain interface [polypeptide binding]; other site 288705003108 active site 288705003109 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 288705003110 active site 288705003111 N-terminal domain interface [polypeptide binding]; other site 288705003112 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 288705003113 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 288705003114 active site 288705003115 domain interfaces; other site 288705003116 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 288705003117 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 288705003118 active site 288705003119 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 288705003120 dimer interface [polypeptide binding]; other site 288705003121 active site 288705003122 Schiff base residues; other site 288705003123 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 288705003124 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 288705003125 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 288705003126 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288705003127 inhibitor-cofactor binding pocket; inhibition site 288705003128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705003129 catalytic residue [active] 288705003130 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288705003131 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288705003132 Coenzyme A binding pocket [chemical binding]; other site 288705003133 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 288705003134 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 288705003135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705003136 dimer interface [polypeptide binding]; other site 288705003137 conserved gate region; other site 288705003138 ABC-ATPase subunit interface; other site 288705003139 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 288705003140 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 288705003141 Walker A/P-loop; other site 288705003142 ATP binding site [chemical binding]; other site 288705003143 Q-loop/lid; other site 288705003144 ABC transporter signature motif; other site 288705003145 Walker B; other site 288705003146 D-loop; other site 288705003147 H-loop/switch region; other site 288705003148 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 288705003149 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 288705003150 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 288705003151 active site 288705003152 catalytic site [active] 288705003153 substrate binding site [chemical binding]; other site 288705003154 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 288705003155 active site 288705003156 DNA binding site [nucleotide binding] 288705003157 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 288705003158 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 288705003159 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 288705003160 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 288705003161 Part of AAA domain; Region: AAA_19; pfam13245 288705003162 Family description; Region: UvrD_C_2; pfam13538 288705003163 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 288705003164 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288705003165 active site 288705003166 substrate binding site [chemical binding]; other site 288705003167 ATP binding site [chemical binding]; other site 288705003168 Phosphotransferase enzyme family; Region: APH; pfam01636 288705003169 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 288705003170 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 288705003171 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 288705003172 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 288705003173 putative NADH binding site [chemical binding]; other site 288705003174 putative active site [active] 288705003175 nudix motif; other site 288705003176 putative metal binding site [ion binding]; other site 288705003177 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 288705003178 Part of AAA domain; Region: AAA_19; pfam13245 288705003179 Family description; Region: UvrD_C_2; pfam13538 288705003180 HRDC domain; Region: HRDC; pfam00570 288705003181 Protein of unknown function DUF45; Region: DUF45; cl00636 288705003182 Methyltransferase domain; Region: Methyltransf_23; pfam13489 288705003183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705003184 S-adenosylmethionine binding site [chemical binding]; other site 288705003185 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 288705003186 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 288705003187 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 288705003188 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 288705003189 protein binding site [polypeptide binding]; other site 288705003190 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 288705003191 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 288705003192 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288705003193 cleavage site 288705003194 active site 288705003195 Predicted transcriptional regulators [Transcription]; Region: COG1733 288705003196 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 288705003197 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 288705003198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705003199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705003200 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288705003201 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288705003202 Catalytic site [active] 288705003203 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 288705003204 AsnC family; Region: AsnC_trans_reg; pfam01037 288705003205 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 288705003206 active site residue [active] 288705003207 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 288705003208 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 288705003209 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 288705003210 DNA photolyase; Region: DNA_photolyase; pfam00875 288705003211 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 288705003212 oxyanion hole [active] 288705003213 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 288705003214 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 288705003215 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 288705003216 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 288705003217 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 288705003218 protein binding site [polypeptide binding]; other site 288705003219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705003220 ABC transporter signature motif; other site 288705003221 Walker B; other site 288705003222 D-loop; other site 288705003223 H-loop/switch region; other site 288705003224 putative transposase OrfB; Reviewed; Region: PHA02517 288705003225 HTH-like domain; Region: HTH_21; pfam13276 288705003226 Integrase core domain; Region: rve; pfam00665 288705003227 Integrase core domain; Region: rve_3; pfam13683 288705003228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705003229 Transposase; Region: HTH_Tnp_1; cl17663 288705003230 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 288705003231 Ligand binding site [chemical binding]; other site 288705003232 Electron transfer flavoprotein domain; Region: ETF; pfam01012 288705003233 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 288705003234 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 288705003235 Ligand Binding Site [chemical binding]; other site 288705003236 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 288705003237 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288705003238 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 288705003239 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 288705003240 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288705003241 DNA binding residues [nucleotide binding] 288705003242 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288705003243 dimer interface [polypeptide binding]; other site 288705003244 Anti-sigma-K factor rskA; Region: RskA; pfam10099 288705003245 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 288705003246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288705003247 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288705003248 DNA binding residues [nucleotide binding] 288705003249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 288705003250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 288705003251 S-adenosylmethionine binding site [chemical binding]; other site 288705003252 Methyltransferase domain; Region: Methyltransf_18; pfam12847 288705003253 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 288705003254 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 288705003255 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 288705003256 HSP70 interaction site [polypeptide binding]; other site 288705003257 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288705003258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705003259 Coenzyme A binding pocket [chemical binding]; other site 288705003260 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 288705003261 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 288705003262 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 288705003263 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 288705003264 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 288705003265 GatB domain; Region: GatB_Yqey; smart00845 288705003266 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288705003267 substrate binding sites [chemical binding]; other site 288705003268 putative transposase OrfB; Reviewed; Region: PHA02517 288705003269 HTH-like domain; Region: HTH_21; pfam13276 288705003270 Integrase core domain; Region: rve; pfam00665 288705003271 Integrase core domain; Region: rve_3; pfam13683 288705003272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705003273 Transposase; Region: HTH_Tnp_1; cl17663 288705003274 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288705003275 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288705003276 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 288705003277 classical (c) SDRs; Region: SDR_c; cd05233 288705003278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705003279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288705003280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288705003281 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 288705003282 putative dimerization interface [polypeptide binding]; other site 288705003283 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 288705003284 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 288705003285 NAD(P) binding site [chemical binding]; other site 288705003286 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 288705003287 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 288705003288 substrate-cofactor binding pocket; other site 288705003289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705003290 catalytic residue [active] 288705003291 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 288705003292 metal binding site [ion binding]; metal-binding site 288705003293 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 288705003294 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 288705003295 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 288705003296 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 288705003297 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288705003298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288705003299 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288705003300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705003301 ABC-ATPase subunit interface; other site 288705003302 putative PBP binding loops; other site 288705003303 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288705003304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705003305 dimer interface [polypeptide binding]; other site 288705003306 conserved gate region; other site 288705003307 putative PBP binding loops; other site 288705003308 ABC-ATPase subunit interface; other site 288705003309 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288705003310 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288705003311 Q-loop/lid; other site 288705003312 ABC transporter signature motif; other site 288705003313 Walker B; other site 288705003314 D-loop; other site 288705003315 H-loop/switch region; other site 288705003316 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288705003317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705003318 Walker A/P-loop; other site 288705003319 ATP binding site [chemical binding]; other site 288705003320 Q-loop/lid; other site 288705003321 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288705003322 ABC transporter signature motif; other site 288705003323 Walker B; other site 288705003324 D-loop; other site 288705003325 H-loop/switch region; other site 288705003326 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288705003327 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 288705003328 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 288705003329 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288705003330 Beta-lactamase; Region: Beta-lactamase; pfam00144 288705003331 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 288705003332 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 288705003333 Uncharacterized conserved protein [Function unknown]; Region: COG3375 288705003334 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 288705003335 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 288705003336 metal binding site [ion binding]; metal-binding site 288705003337 substrate binding pocket [chemical binding]; other site 288705003338 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 288705003339 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 288705003340 active sites [active] 288705003341 tetramer interface [polypeptide binding]; other site 288705003342 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705003343 Transcriptional regulator [Transcription]; Region: IclR; COG1414 288705003344 dimerization interface [polypeptide binding]; other site 288705003345 putative DNA binding site [nucleotide binding]; other site 288705003346 putative Zn2+ binding site [ion binding]; other site 288705003347 urocanate hydratase; Provisional; Region: PRK05414 288705003348 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 288705003349 allantoate amidohydrolase; Reviewed; Region: PRK09290 288705003350 active site 288705003351 metal binding site [ion binding]; metal-binding site 288705003352 dimer interface [polypeptide binding]; other site 288705003353 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 288705003354 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 288705003355 active site 288705003356 imidazolonepropionase; Provisional; Region: PRK14085 288705003357 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 288705003358 active site 288705003359 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 288705003360 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 288705003361 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 288705003362 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 288705003363 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 288705003364 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 288705003365 dimer interface [polypeptide binding]; other site 288705003366 active site 288705003367 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 288705003368 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288705003369 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288705003370 nucleotide binding site [chemical binding]; other site 288705003371 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 288705003372 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288705003373 putative substrate binding site [chemical binding]; other site 288705003374 putative ATP binding site [chemical binding]; other site 288705003375 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 288705003376 active site 288705003377 intersubunit interface [polypeptide binding]; other site 288705003378 zinc binding site [ion binding]; other site 288705003379 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288705003380 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 288705003381 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 288705003382 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 288705003383 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 288705003384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705003385 Transposase; Region: HTH_Tnp_1; cl17663 288705003386 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 288705003387 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 288705003388 NAD(P) binding site [chemical binding]; other site 288705003389 homodimer interface [polypeptide binding]; other site 288705003390 substrate binding site [chemical binding]; other site 288705003391 active site 288705003392 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 288705003393 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 288705003394 putative glycosyl transferase; Provisional; Region: PRK10307 288705003395 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 288705003396 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 288705003397 NADP-binding site; other site 288705003398 homotetramer interface [polypeptide binding]; other site 288705003399 substrate binding site [chemical binding]; other site 288705003400 homodimer interface [polypeptide binding]; other site 288705003401 active site 288705003402 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 288705003403 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 288705003404 NADP-binding site; other site 288705003405 homotetramer interface [polypeptide binding]; other site 288705003406 substrate binding site [chemical binding]; other site 288705003407 homodimer interface [polypeptide binding]; other site 288705003408 active site 288705003409 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 288705003410 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288705003411 putative transposase OrfB; Reviewed; Region: PHA02517 288705003412 HTH-like domain; Region: HTH_21; pfam13276 288705003413 Integrase core domain; Region: rve; pfam00665 288705003414 Integrase core domain; Region: rve_3; pfam13683 288705003415 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705003416 Transposase; Region: HTH_Tnp_1; cl17663 288705003417 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 288705003418 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 288705003419 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 288705003420 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 288705003421 Walker A motif; other site 288705003422 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 288705003423 Walker B motif; other site 288705003424 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 288705003425 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 288705003426 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 288705003427 TadE-like protein; Region: TadE; pfam07811 288705003428 peptide chain release factor 2; Validated; Region: prfB; PRK00578 288705003429 This domain is found in peptide chain release factors; Region: PCRF; smart00937 288705003430 RF-1 domain; Region: RF-1; pfam00472 288705003431 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 288705003432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705003433 Walker A/P-loop; other site 288705003434 ATP binding site [chemical binding]; other site 288705003435 Q-loop/lid; other site 288705003436 ABC transporter signature motif; other site 288705003437 Walker B; other site 288705003438 D-loop; other site 288705003439 H-loop/switch region; other site 288705003440 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 288705003441 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 288705003442 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 288705003443 Peptidase family M23; Region: Peptidase_M23; pfam01551 288705003444 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 288705003445 SmpB-tmRNA interface; other site 288705003446 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 288705003447 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 288705003448 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 288705003449 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 288705003450 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 288705003451 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288705003452 amidase catalytic site [active] 288705003453 Zn binding residues [ion binding]; other site 288705003454 substrate binding site [chemical binding]; other site 288705003455 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288705003456 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288705003457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705003458 Transposase; Region: HTH_Tnp_1; cl17663 288705003459 putative transposase OrfB; Reviewed; Region: PHA02517 288705003460 HTH-like domain; Region: HTH_21; pfam13276 288705003461 Integrase core domain; Region: rve; pfam00665 288705003462 Integrase core domain; Region: rve_3; pfam13683 288705003463 CrcB-like protein; Region: CRCB; cl09114 288705003464 CrcB-like protein; Region: CRCB; cl09114 288705003465 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 288705003466 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 288705003467 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 288705003468 FeoA domain; Region: FeoA; pfam04023 288705003469 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 288705003470 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 288705003471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705003472 S-adenosylmethionine binding site [chemical binding]; other site 288705003473 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 288705003474 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705003475 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705003476 catalytic residue [active] 288705003477 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 288705003478 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 288705003479 active site 288705003480 ribosome small subunit-dependent GTPase A; Region: TIGR00157 288705003481 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 288705003482 GTPase/Zn-binding domain interface [polypeptide binding]; other site 288705003483 GTP/Mg2+ binding site [chemical binding]; other site 288705003484 G4 box; other site 288705003485 G5 box; other site 288705003486 G1 box; other site 288705003487 Switch I region; other site 288705003488 G2 box; other site 288705003489 G3 box; other site 288705003490 Switch II region; other site 288705003491 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 288705003492 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 288705003493 hinge; other site 288705003494 active site 288705003495 Predicted membrane protein [Function unknown]; Region: COG2259 288705003496 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 288705003497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288705003498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288705003499 DNA binding residues [nucleotide binding] 288705003500 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 288705003501 Predicted transcriptional regulators [Transcription]; Region: COG1695 288705003502 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288705003503 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 288705003504 active site 288705003505 catalytic triad [active] 288705003506 oxyanion hole [active] 288705003507 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 288705003508 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 288705003509 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 288705003510 TPP-binding site [chemical binding]; other site 288705003511 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 288705003512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705003513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705003514 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288705003515 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 288705003516 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 288705003517 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 288705003518 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 288705003519 active site 288705003520 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 288705003521 Domain of unknown function DUF21; Region: DUF21; pfam01595 288705003522 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 288705003523 Transporter associated domain; Region: CorC_HlyC; smart01091 288705003524 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 288705003525 Domain of unknown function DUF21; Region: DUF21; pfam01595 288705003526 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 288705003527 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 288705003528 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 288705003529 intersubunit interface [polypeptide binding]; other site 288705003530 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 288705003531 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 288705003532 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 288705003533 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 288705003534 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 288705003535 metal binding site 2 [ion binding]; metal-binding site 288705003536 putative DNA binding helix; other site 288705003537 metal binding site 1 [ion binding]; metal-binding site 288705003538 dimer interface [polypeptide binding]; other site 288705003539 structural Zn2+ binding site [ion binding]; other site 288705003540 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 288705003541 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288705003542 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 288705003543 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 288705003544 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705003545 catalytic residue [active] 288705003546 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 288705003547 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 288705003548 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 288705003549 active site residue [active] 288705003550 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 288705003551 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 288705003552 active site residue [active] 288705003553 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 288705003554 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 288705003555 putative NAD(P) binding site [chemical binding]; other site 288705003556 putative substrate binding site [chemical binding]; other site 288705003557 catalytic Zn binding site [ion binding]; other site 288705003558 structural Zn binding site [ion binding]; other site 288705003559 dimer interface [polypeptide binding]; other site 288705003560 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 288705003561 nucleotide binding site/active site [active] 288705003562 HIT family signature motif; other site 288705003563 catalytic residue [active] 288705003564 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 288705003565 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 288705003566 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 288705003567 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705003568 dimerization interface [polypeptide binding]; other site 288705003569 putative DNA binding site [nucleotide binding]; other site 288705003570 putative Zn2+ binding site [ion binding]; other site 288705003571 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 288705003572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288705003573 ATP binding site [chemical binding]; other site 288705003574 putative Mg++ binding site [ion binding]; other site 288705003575 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705003576 nucleotide binding region [chemical binding]; other site 288705003577 ATP-binding site [chemical binding]; other site 288705003578 Helicase associated domain (HA2); Region: HA2; pfam04408 288705003579 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 288705003580 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 288705003581 Predicted transcriptional regulator [Transcription]; Region: COG2378 288705003582 HTH domain; Region: HTH_11; pfam08279 288705003583 WYL domain; Region: WYL; pfam13280 288705003584 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 288705003585 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 288705003586 conserved cys residue [active] 288705003587 hypothetical protein; Provisional; Region: PRK07758 288705003588 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 288705003589 NAD binding pocket [chemical binding]; other site 288705003590 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 288705003591 FAD binding pocket [chemical binding]; other site 288705003592 conserved FAD binding motif [chemical binding]; other site 288705003593 phosphate binding motif [ion binding]; other site 288705003594 ApbE family; Region: ApbE; pfam02424 288705003595 FMN-binding domain; Region: FMN_bind; cl01081 288705003596 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 288705003597 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 288705003598 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 288705003599 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 288705003600 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 288705003601 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 288705003602 active site 288705003603 HIGH motif; other site 288705003604 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 288705003605 KMSK motif region; other site 288705003606 tRNA binding surface [nucleotide binding]; other site 288705003607 DALR anticodon binding domain; Region: DALR_1; smart00836 288705003608 anticodon binding site; other site 288705003609 diaminopimelate decarboxylase; Region: lysA; TIGR01048 288705003610 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 288705003611 active site 288705003612 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288705003613 substrate binding site [chemical binding]; other site 288705003614 catalytic residues [active] 288705003615 dimer interface [polypeptide binding]; other site 288705003616 homoserine dehydrogenase; Provisional; Region: PRK06349 288705003617 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 288705003618 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 288705003619 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 288705003620 threonine synthase; Reviewed; Region: PRK06721 288705003621 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 288705003622 homodimer interface [polypeptide binding]; other site 288705003623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705003624 catalytic residue [active] 288705003625 homoserine kinase; Provisional; Region: PRK01212 288705003626 transcription termination factor Rho; Provisional; Region: PRK12608 288705003627 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288705003628 RNA binding site [nucleotide binding]; other site 288705003629 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 288705003630 Walker A motif; other site 288705003631 ATP binding site [chemical binding]; other site 288705003632 Walker B motif; other site 288705003633 peptide chain release factor 1; Validated; Region: prfA; PRK00591 288705003634 This domain is found in peptide chain release factors; Region: PCRF; smart00937 288705003635 RF-1 domain; Region: RF-1; pfam00472 288705003636 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 288705003637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705003638 S-adenosylmethionine binding site [chemical binding]; other site 288705003639 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 288705003640 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 288705003641 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288705003642 active site 288705003643 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 288705003644 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288705003645 active site 288705003646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705003647 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288705003648 NAD(P) binding site [chemical binding]; other site 288705003649 active site 288705003650 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 288705003651 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 288705003652 NAD(P) binding site [chemical binding]; other site 288705003653 homodimer interface [polypeptide binding]; other site 288705003654 substrate binding site [chemical binding]; other site 288705003655 active site 288705003656 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 288705003657 Mg++ binding site [ion binding]; other site 288705003658 putative catalytic motif [active] 288705003659 putative substrate binding site [chemical binding]; other site 288705003660 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 288705003661 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 288705003662 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 288705003663 ATP synthase subunit C; Region: ATP-synt_C; cl00466 288705003664 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 288705003665 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 288705003666 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 288705003667 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 288705003668 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 288705003669 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 288705003670 beta subunit interaction interface [polypeptide binding]; other site 288705003671 Walker A motif; other site 288705003672 ATP binding site [chemical binding]; other site 288705003673 Walker B motif; other site 288705003674 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 288705003675 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 288705003676 core domain interface [polypeptide binding]; other site 288705003677 delta subunit interface [polypeptide binding]; other site 288705003678 epsilon subunit interface [polypeptide binding]; other site 288705003679 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 288705003680 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 288705003681 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 288705003682 alpha subunit interaction interface [polypeptide binding]; other site 288705003683 Walker A motif; other site 288705003684 ATP binding site [chemical binding]; other site 288705003685 Walker B motif; other site 288705003686 inhibitor binding site; inhibition site 288705003687 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 288705003688 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 288705003689 gamma subunit interface [polypeptide binding]; other site 288705003690 epsilon subunit interface [polypeptide binding]; other site 288705003691 LBP interface [polypeptide binding]; other site 288705003692 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 288705003693 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 288705003694 DNA-binding site [nucleotide binding]; DNA binding site 288705003695 RNA-binding motif; other site 288705003696 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 288705003697 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 288705003698 active site 288705003699 dimer interface [polypeptide binding]; other site 288705003700 hypothetical protein; Provisional; Region: PRK03298 288705003701 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288705003702 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 288705003703 Domain of unknown function DUF20; Region: UPF0118; pfam01594 288705003704 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 288705003705 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 288705003706 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 288705003707 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 288705003708 active site 288705003709 FMN binding site [chemical binding]; other site 288705003710 substrate binding site [chemical binding]; other site 288705003711 homotetramer interface [polypeptide binding]; other site 288705003712 catalytic residue [active] 288705003713 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288705003714 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288705003715 Walker A/P-loop; other site 288705003716 ATP binding site [chemical binding]; other site 288705003717 Q-loop/lid; other site 288705003718 ABC transporter signature motif; other site 288705003719 Walker B; other site 288705003720 D-loop; other site 288705003721 H-loop/switch region; other site 288705003722 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 288705003723 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 288705003724 active site 288705003725 trimer interface [polypeptide binding]; other site 288705003726 allosteric site; other site 288705003727 active site lid [active] 288705003728 hexamer (dimer of trimers) interface [polypeptide binding]; other site 288705003729 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 288705003730 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 288705003731 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288705003732 ATP binding site [chemical binding]; other site 288705003733 putative Mg++ binding site [ion binding]; other site 288705003734 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 288705003735 active site 288705003736 dimer interface [polypeptide binding]; other site 288705003737 motif 1; other site 288705003738 motif 2; other site 288705003739 motif 3; other site 288705003740 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 288705003741 anticodon binding site; other site 288705003742 Isochorismatase family; Region: Isochorismatase; pfam00857 288705003743 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 288705003744 catalytic triad [active] 288705003745 metal binding site [ion binding]; metal-binding site 288705003746 conserved cis-peptide bond; other site 288705003747 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 288705003748 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 288705003749 active site 288705003750 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 288705003751 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 288705003752 glutamate racemase; Provisional; Region: PRK00865 288705003753 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 288705003754 ribonuclease PH; Reviewed; Region: rph; PRK00173 288705003755 Ribonuclease PH; Region: RNase_PH_bact; cd11362 288705003756 hexamer interface [polypeptide binding]; other site 288705003757 active site 288705003758 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 288705003759 active site 288705003760 dimerization interface [polypeptide binding]; other site 288705003761 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 288705003762 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 288705003763 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 288705003764 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 288705003765 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 288705003766 cardiolipin synthetase; Reviewed; Region: PRK12452 288705003767 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 288705003768 nudix motif; other site 288705003769 Predicted transcriptional regulators [Transcription]; Region: COG1725 288705003770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705003771 DNA-binding site [nucleotide binding]; DNA binding site 288705003772 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288705003773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705003774 ABC transporter signature motif; other site 288705003775 Walker B; other site 288705003776 D-loop; other site 288705003777 H-loop/switch region; other site 288705003778 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 288705003779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288705003780 motif II; other site 288705003781 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 288705003782 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 288705003783 active site 288705003784 catalytic site [active] 288705003785 substrate binding site [chemical binding]; other site 288705003786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705003787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705003788 NAD(P) binding site [chemical binding]; other site 288705003789 Protein of unknown function (DUF419); Region: DUF419; pfam04237 288705003790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705003791 Transposase; Region: HTH_Tnp_1; cl17663 288705003792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 288705003793 HTH-like domain; Region: HTH_21; pfam13276 288705003794 Integrase core domain; Region: rve; pfam00665 288705003795 Integrase core domain; Region: rve_3; pfam13683 288705003796 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 288705003797 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 288705003798 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 288705003799 amphipathic channel; other site 288705003800 Asn-Pro-Ala signature motifs; other site 288705003801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705003802 Walker A/P-loop; other site 288705003803 ATP binding site [chemical binding]; other site 288705003804 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 288705003805 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 288705003806 active site 288705003807 metal binding site [ion binding]; metal-binding site 288705003808 DNA binding site [nucleotide binding] 288705003809 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 288705003810 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 288705003811 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 288705003812 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705003813 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 288705003814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705003815 Coenzyme A binding pocket [chemical binding]; other site 288705003816 metabolite-proton symporter; Region: 2A0106; TIGR00883 288705003817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705003818 putative substrate translocation pore; other site 288705003819 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288705003820 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 288705003821 tetramer interface [polypeptide binding]; other site 288705003822 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288705003823 active site 288705003824 metal binding site [ion binding]; metal-binding site 288705003825 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288705003826 active site 288705003827 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 288705003828 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 288705003829 NAD binding site [chemical binding]; other site 288705003830 catalytic residues [active] 288705003831 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 288705003832 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 288705003833 dimer interface [polypeptide binding]; other site 288705003834 active site 288705003835 catalytic residue [active] 288705003836 Transcriptional regulators [Transcription]; Region: GntR; COG1802 288705003837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705003838 DNA-binding site [nucleotide binding]; DNA binding site 288705003839 FCD domain; Region: FCD; pfam07729 288705003840 hypothetical protein; Provisional; Region: PRK12764 288705003841 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 288705003842 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 288705003843 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 288705003844 Catalytic domain of Protein Kinases; Region: PKc; cd00180 288705003845 active site 288705003846 ATP binding site [chemical binding]; other site 288705003847 substrate binding site [chemical binding]; other site 288705003848 activation loop (A-loop); other site 288705003849 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 288705003850 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288705003851 nucleophilic elbow; other site 288705003852 catalytic triad; other site 288705003853 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288705003854 E3 interaction surface; other site 288705003855 lipoyl attachment site [posttranslational modification]; other site 288705003856 HlyD family secretion protein; Region: HlyD_3; pfam13437 288705003857 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 288705003858 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 288705003859 alpha subunit interface [polypeptide binding]; other site 288705003860 TPP binding site [chemical binding]; other site 288705003861 heterodimer interface [polypeptide binding]; other site 288705003862 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288705003863 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 288705003864 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 288705003865 tetramer interface [polypeptide binding]; other site 288705003866 TPP-binding site [chemical binding]; other site 288705003867 heterodimer interface [polypeptide binding]; other site 288705003868 phosphorylation loop region [posttranslational modification] 288705003869 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 288705003870 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 288705003871 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 288705003872 AsnC family; Region: AsnC_trans_reg; pfam01037 288705003873 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 288705003874 nudix motif; other site 288705003875 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 288705003876 quinolinate synthetase; Provisional; Region: PRK09375 288705003877 L-aspartate oxidase; Provisional; Region: PRK06175 288705003878 L-aspartate oxidase; Provisional; Region: PRK06175 288705003879 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 288705003880 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 288705003881 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705003882 catalytic residue [active] 288705003883 SnoaL-like domain; Region: SnoaL_2; pfam12680 288705003884 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288705003885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288705003886 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288705003887 dimerization interface [polypeptide binding]; other site 288705003888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288705003889 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288705003890 GtrA-like protein; Region: GtrA; pfam04138 288705003891 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 288705003892 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 288705003893 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 288705003894 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 288705003895 putative active site [active] 288705003896 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 288705003897 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 288705003898 active site 288705003899 metal binding site [ion binding]; metal-binding site 288705003900 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 288705003901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705003902 dimer interface [polypeptide binding]; other site 288705003903 conserved gate region; other site 288705003904 ABC-ATPase subunit interface; other site 288705003905 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 288705003906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288705003907 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 288705003908 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 288705003909 Walker A/P-loop; other site 288705003910 ATP binding site [chemical binding]; other site 288705003911 Q-loop/lid; other site 288705003912 ABC transporter signature motif; other site 288705003913 Walker B; other site 288705003914 D-loop; other site 288705003915 H-loop/switch region; other site 288705003916 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 288705003917 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 288705003918 hypothetical protein; Provisional; Region: PRK08262 288705003919 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 288705003920 metal binding site [ion binding]; metal-binding site 288705003921 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 288705003922 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 288705003923 MarR family; Region: MarR_2; pfam12802 288705003924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705003925 Transposase; Region: HTH_Tnp_1; cl17663 288705003926 putative transposase OrfB; Reviewed; Region: PHA02517 288705003927 HTH-like domain; Region: HTH_21; pfam13276 288705003928 Integrase core domain; Region: rve; pfam00665 288705003929 Integrase core domain; Region: rve_3; pfam13683 288705003930 flavodoxin; Provisional; Region: PRK06242 288705003931 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288705003932 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 288705003933 Predicted transcriptional regulator [Transcription]; Region: COG2378 288705003934 HTH domain; Region: HTH_11; pfam08279 288705003935 WYL domain; Region: WYL; pfam13280 288705003936 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 288705003937 active site 288705003938 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 288705003939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705003940 H-loop/switch region; other site 288705003941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705003942 Walker A/P-loop; other site 288705003943 ATP binding site [chemical binding]; other site 288705003944 Q-loop/lid; other site 288705003945 ABC transporter signature motif; other site 288705003946 Walker B; other site 288705003947 D-loop; other site 288705003948 H-loop/switch region; other site 288705003949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705003950 ABC transporter signature motif; other site 288705003951 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 288705003952 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 288705003953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288705003954 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288705003955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288705003956 Cna protein B-type domain; Region: Cna_B; pfam05738 288705003957 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 288705003958 Cna protein B-type domain; Region: Cna_B; pfam05738 288705003959 Cna protein B-type domain; Region: Cna_B; pfam05738 288705003960 Cna protein B-type domain; Region: Cna_B; pfam05738 288705003961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705003962 NAD(P) binding site [chemical binding]; other site 288705003963 active site 288705003964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705003965 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 288705003966 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 288705003967 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 288705003968 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288705003969 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 288705003970 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 288705003971 inhibitor site; inhibition site 288705003972 active site 288705003973 dimer interface [polypeptide binding]; other site 288705003974 catalytic residue [active] 288705003975 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 288705003976 Phosphotransferase enzyme family; Region: APH; pfam01636 288705003977 putative active site [active] 288705003978 ATP binding site [chemical binding]; other site 288705003979 putative substrate binding site [chemical binding]; other site 288705003980 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 288705003981 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288705003982 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288705003983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705003984 S-adenosylmethionine binding site [chemical binding]; other site 288705003985 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 288705003986 dimer interface [polypeptide binding]; other site 288705003987 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 288705003988 dimer interface [polypeptide binding]; other site 288705003989 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 288705003990 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 288705003991 TPP-binding site [chemical binding]; other site 288705003992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288705003993 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 288705003994 motif II; other site 288705003995 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 288705003996 substrate binding site [chemical binding]; other site 288705003997 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 288705003998 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 288705003999 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 288705004000 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 288705004001 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 288705004002 hydrophobic ligand binding site; other site 288705004003 Helix-turn-helix domain; Region: HTH_20; pfam12840 288705004004 dimerization interface [polypeptide binding]; other site 288705004005 putative DNA binding site [nucleotide binding]; other site 288705004006 putative Zn2+ binding site [ion binding]; other site 288705004007 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 288705004008 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288705004009 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288705004010 DNA binding residues [nucleotide binding] 288705004011 Putative zinc-finger; Region: zf-HC2; pfam13490 288705004012 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 288705004013 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 288705004014 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 288705004015 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 288705004016 AsnC family; Region: AsnC_trans_reg; pfam01037 288705004017 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 288705004018 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 288705004019 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 288705004020 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 288705004021 Subunit I/III interface [polypeptide binding]; other site 288705004022 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 288705004023 Cytochrome c; Region: Cytochrom_C; pfam00034 288705004024 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 288705004025 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 288705004026 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 288705004027 iron-sulfur cluster [ion binding]; other site 288705004028 [2Fe-2S] cluster binding site [ion binding]; other site 288705004029 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 288705004030 intrachain domain interface; other site 288705004031 interchain domain interface [polypeptide binding]; other site 288705004032 heme bL binding site [chemical binding]; other site 288705004033 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 288705004034 heme bH binding site [chemical binding]; other site 288705004035 Qo binding site; other site 288705004036 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288705004037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705004038 DNA-binding site [nucleotide binding]; DNA binding site 288705004039 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 288705004040 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 288705004041 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 288705004042 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 288705004043 D-pathway; other site 288705004044 Putative ubiquinol binding site [chemical binding]; other site 288705004045 Low-spin heme (heme b) binding site [chemical binding]; other site 288705004046 Putative water exit pathway; other site 288705004047 Binuclear center (heme o3/CuB) [ion binding]; other site 288705004048 K-pathway; other site 288705004049 Putative proton exit pathway; other site 288705004050 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 288705004051 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 288705004052 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 288705004053 hypothetical protein; Provisional; Region: PRK07907 288705004054 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 288705004055 active site 288705004056 metal binding site [ion binding]; metal-binding site 288705004057 dimer interface [polypeptide binding]; other site 288705004058 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 288705004059 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 288705004060 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 288705004061 quinone interaction residues [chemical binding]; other site 288705004062 active site 288705004063 catalytic residues [active] 288705004064 FMN binding site [chemical binding]; other site 288705004065 substrate binding site [chemical binding]; other site 288705004066 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288705004067 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288705004068 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288705004069 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288705004070 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 288705004071 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 288705004072 catalytic residue [active] 288705004073 putative FPP diphosphate binding site; other site 288705004074 putative FPP binding hydrophobic cleft; other site 288705004075 dimer interface [polypeptide binding]; other site 288705004076 putative IPP diphosphate binding site; other site 288705004077 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 288705004078 Recombination protein O N terminal; Region: RecO_N; pfam11967 288705004079 Recombination protein O C terminal; Region: RecO_C; pfam02565 288705004080 2-isopropylmalate synthase; Validated; Region: PRK03739 288705004081 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 288705004082 active site 288705004083 catalytic residues [active] 288705004084 metal binding site [ion binding]; metal-binding site 288705004085 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 288705004086 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 288705004087 active site 288705004088 Zn binding site [ion binding]; other site 288705004089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705004090 Transposase; Region: HTH_Tnp_1; cl17663 288705004091 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 288705004092 active site 288705004093 catalytic triad [active] 288705004094 oxyanion hole [active] 288705004095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705004096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705004097 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 288705004098 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 288705004099 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 288705004100 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705004101 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705004102 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705004103 catalytic residue [active] 288705004104 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 288705004105 CAAX protease self-immunity; Region: Abi; pfam02517 288705004106 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288705004107 catalytic core [active] 288705004108 Iron permease FTR1 family; Region: FTR1; cl00475 288705004109 Transposase; Region: HTH_Tnp_1; cl17663 288705004110 putative transposase OrfB; Reviewed; Region: PHA02517 288705004111 HTH-like domain; Region: HTH_21; pfam13276 288705004112 Integrase core domain; Region: rve; pfam00665 288705004113 Integrase core domain; Region: rve_3; pfam13683 288705004114 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 288705004115 Ligand binding site; other site 288705004116 Putative Catalytic site; other site 288705004117 DXD motif; other site 288705004118 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 288705004119 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 288705004120 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 288705004121 active site 288705004122 homodimer interface [polypeptide binding]; other site 288705004123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705004124 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 288705004125 NAD(P) binding site [chemical binding]; other site 288705004126 active site 288705004127 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 288705004128 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 288705004129 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 288705004130 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 288705004131 Walker A/P-loop; other site 288705004132 ATP binding site [chemical binding]; other site 288705004133 Q-loop/lid; other site 288705004134 ABC transporter signature motif; other site 288705004135 Walker B; other site 288705004136 D-loop; other site 288705004137 H-loop/switch region; other site 288705004138 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 288705004139 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 288705004140 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288705004141 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 288705004142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288705004143 UDP-galactopyranose mutase; Region: GLF; pfam03275 288705004144 Transcription factor WhiB; Region: Whib; pfam02467 288705004145 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 288705004146 PAS fold; Region: PAS_4; pfam08448 288705004147 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 288705004148 Histidine kinase; Region: HisKA_2; pfam07568 288705004149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288705004150 ATP binding site [chemical binding]; other site 288705004151 Mg2+ binding site [ion binding]; other site 288705004152 G-X-G motif; other site 288705004153 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 288705004154 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 288705004155 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 288705004156 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 288705004157 active site 288705004158 GIY-YIG motif/motif A; other site 288705004159 catalytic site [active] 288705004160 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 288705004161 Helix-turn-helix domain; Region: HTH_17; pfam12728 288705004162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705004163 Transposase; Region: HTH_Tnp_1; cl17663 288705004164 putative transposase OrfB; Reviewed; Region: PHA02517 288705004165 HTH-like domain; Region: HTH_21; pfam13276 288705004166 Integrase core domain; Region: rve; pfam00665 288705004167 Integrase core domain; Region: rve_3; pfam13683 288705004168 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 288705004169 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 288705004170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705004171 nucleotide binding region [chemical binding]; other site 288705004172 putative transposase OrfB; Reviewed; Region: PHA02517 288705004173 HTH-like domain; Region: HTH_21; pfam13276 288705004174 Integrase core domain; Region: rve; pfam00665 288705004175 Integrase core domain; Region: rve_3; pfam13683 288705004176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705004177 Transposase; Region: HTH_Tnp_1; cl17663 288705004178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 288705004179 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 288705004180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 288705004181 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 288705004182 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 288705004183 30S subunit binding site; other site 288705004184 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 288705004185 lipoprotein LpqB; Provisional; Region: PRK13614 288705004186 Sporulation and spore germination; Region: Germane; pfam10646 288705004187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288705004188 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288705004189 dimerization interface [polypeptide binding]; other site 288705004190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288705004191 dimer interface [polypeptide binding]; other site 288705004192 phosphorylation site [posttranslational modification] 288705004193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288705004194 ATP binding site [chemical binding]; other site 288705004195 Mg2+ binding site [ion binding]; other site 288705004196 G-X-G motif; other site 288705004197 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288705004198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705004199 active site 288705004200 phosphorylation site [posttranslational modification] 288705004201 intermolecular recognition site; other site 288705004202 dimerization interface [polypeptide binding]; other site 288705004203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288705004204 DNA binding site [nucleotide binding] 288705004205 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 288705004206 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 288705004207 MoxR-like ATPases [General function prediction only]; Region: COG0714 288705004208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705004209 Walker A motif; other site 288705004210 ATP binding site [chemical binding]; other site 288705004211 Walker B motif; other site 288705004212 arginine finger; other site 288705004213 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 288705004214 Protein of unknown function DUF58; Region: DUF58; pfam01882 288705004215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288705004216 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288705004217 non-specific DNA binding site [nucleotide binding]; other site 288705004218 salt bridge; other site 288705004219 sequence-specific DNA binding site [nucleotide binding]; other site 288705004220 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 288705004221 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 288705004222 oligomer interface [polypeptide binding]; other site 288705004223 active site residues [active] 288705004224 Clp protease; Region: CLP_protease; pfam00574 288705004225 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 288705004226 oligomer interface [polypeptide binding]; other site 288705004227 active site residues [active] 288705004228 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 288705004229 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 288705004230 chorismate mutase; Provisional; Region: PRK09239 288705004231 Helix-turn-helix domain; Region: HTH_31; pfam13560 288705004232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705004233 putative substrate translocation pore; other site 288705004234 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288705004235 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288705004236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705004237 Walker B; other site 288705004238 D-loop; other site 288705004239 H-loop/switch region; other site 288705004240 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288705004241 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 288705004242 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288705004243 Walker A/P-loop; other site 288705004244 ATP binding site [chemical binding]; other site 288705004245 Q-loop/lid; other site 288705004246 ABC transporter signature motif; other site 288705004247 Walker B; other site 288705004248 D-loop; other site 288705004249 H-loop/switch region; other site 288705004250 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288705004251 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288705004252 Walker A/P-loop; other site 288705004253 ATP binding site [chemical binding]; other site 288705004254 Q-loop/lid; other site 288705004255 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288705004256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705004257 dimer interface [polypeptide binding]; other site 288705004258 conserved gate region; other site 288705004259 ABC-ATPase subunit interface; other site 288705004260 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288705004261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705004262 putative PBP binding loops; other site 288705004263 dimer interface [polypeptide binding]; other site 288705004264 ABC-ATPase subunit interface; other site 288705004265 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288705004266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705004267 Transposase; Region: HTH_Tnp_1; cl17663 288705004268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 288705004269 HTH-like domain; Region: HTH_21; pfam13276 288705004270 Integrase core domain; Region: rve; pfam00665 288705004271 Integrase core domain; Region: rve_3; pfam13683 288705004272 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 288705004273 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 288705004274 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 288705004275 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 288705004276 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 288705004277 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 288705004278 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 288705004279 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 288705004280 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 288705004281 catalytic triad [active] 288705004282 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 288705004283 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 288705004284 Ligand Binding Site [chemical binding]; other site 288705004285 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 288705004286 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 288705004287 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705004288 catalytic residue [active] 288705004289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705004290 putative substrate translocation pore; other site 288705004291 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288705004292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705004293 S-adenosylmethionine binding site [chemical binding]; other site 288705004294 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 288705004295 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 288705004296 shikimate binding site; other site 288705004297 NAD(P) binding site [chemical binding]; other site 288705004298 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 288705004299 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 288705004300 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 288705004301 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288705004302 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288705004303 Walker A/P-loop; other site 288705004304 ATP binding site [chemical binding]; other site 288705004305 Q-loop/lid; other site 288705004306 ABC transporter signature motif; other site 288705004307 Walker B; other site 288705004308 D-loop; other site 288705004309 H-loop/switch region; other site 288705004310 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 288705004311 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 288705004312 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288705004313 ABC-ATPase subunit interface; other site 288705004314 dimer interface [polypeptide binding]; other site 288705004315 putative PBP binding regions; other site 288705004316 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 288705004317 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288705004318 ABC-ATPase subunit interface; other site 288705004319 dimer interface [polypeptide binding]; other site 288705004320 putative PBP binding regions; other site 288705004321 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 288705004322 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 288705004323 siderophore binding site; other site 288705004324 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 288705004325 Uncharacterized conserved protein [Function unknown]; Region: COG1434 288705004326 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 288705004327 putative active site [active] 288705004328 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288705004329 cleavage site 288705004330 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288705004331 active site 288705004332 substrate binding sites [chemical binding]; other site 288705004333 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 288705004334 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 288705004335 dimer interface [polypeptide binding]; other site 288705004336 active site 288705004337 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288705004338 catalytic residues [active] 288705004339 substrate binding site [chemical binding]; other site 288705004340 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 288705004341 IucA / IucC family; Region: IucA_IucC; pfam04183 288705004342 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 288705004343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705004344 IucA / IucC family; Region: IucA_IucC; pfam04183 288705004345 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 288705004346 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 288705004347 carboxylate-amine ligase; Provisional; Region: PRK13517 288705004348 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 288705004349 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 288705004350 UGMP family protein; Validated; Region: PRK09604 288705004351 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 288705004352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288705004353 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 288705004354 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288705004355 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 288705004356 Glycoprotease family; Region: Peptidase_M22; pfam00814 288705004357 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 288705004358 alanine racemase; Reviewed; Region: alr; PRK00053 288705004359 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 288705004360 active site 288705004361 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288705004362 dimer interface [polypeptide binding]; other site 288705004363 substrate binding site [chemical binding]; other site 288705004364 catalytic residues [active] 288705004365 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288705004366 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 288705004367 substrate binding site [chemical binding]; other site 288705004368 ATP binding site [chemical binding]; other site 288705004369 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 288705004370 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 288705004371 NAD binding site [chemical binding]; other site 288705004372 sugar binding site [chemical binding]; other site 288705004373 divalent metal binding site [ion binding]; other site 288705004374 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288705004375 dimer interface [polypeptide binding]; other site 288705004376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705004377 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 288705004378 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705004379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705004380 dimer interface [polypeptide binding]; other site 288705004381 ABC-ATPase subunit interface; other site 288705004382 putative PBP binding loops; other site 288705004383 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705004384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288705004385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705004386 putative PBP binding loops; other site 288705004387 ABC-ATPase subunit interface; other site 288705004388 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 288705004389 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 288705004390 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 288705004391 putative ADP-binding pocket [chemical binding]; other site 288705004392 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 288705004393 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 288705004394 Potassium binding sites [ion binding]; other site 288705004395 Cesium cation binding sites [ion binding]; other site 288705004396 putative transposase OrfB; Reviewed; Region: PHA02517 288705004397 HTH-like domain; Region: HTH_21; pfam13276 288705004398 Integrase core domain; Region: rve; pfam00665 288705004399 Integrase core domain; Region: rve_3; pfam13683 288705004400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705004401 Transposase; Region: HTH_Tnp_1; cl17663 288705004402 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 288705004403 putative active site [active] 288705004404 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 288705004405 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 288705004406 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288705004407 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288705004408 active site 288705004409 catalytic tetrad [active] 288705004410 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 288705004411 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 288705004412 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 288705004413 active site 288705004414 catalytic site [active] 288705004415 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 288705004416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705004417 NAD(P) binding site [chemical binding]; other site 288705004418 active site 288705004419 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 288705004420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705004421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705004422 glycine dehydrogenase; Provisional; Region: PRK05367 288705004423 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 288705004424 tetramer interface [polypeptide binding]; other site 288705004425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705004426 catalytic residue [active] 288705004427 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 288705004428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705004429 catalytic residue [active] 288705004430 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 288705004431 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 288705004432 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 288705004433 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 288705004434 lipoyl attachment site [posttranslational modification]; other site 288705004435 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 288705004436 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 288705004437 dimer interface [polypeptide binding]; other site 288705004438 active site 288705004439 glycine-pyridoxal phosphate binding site [chemical binding]; other site 288705004440 folate binding site [chemical binding]; other site 288705004441 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 288705004442 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 288705004443 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 288705004444 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 288705004445 active site clefts [active] 288705004446 zinc binding site [ion binding]; other site 288705004447 dimer interface [polypeptide binding]; other site 288705004448 Uncharacterized conserved protein [Function unknown]; Region: COG0062 288705004449 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 288705004450 putative substrate binding site [chemical binding]; other site 288705004451 putative ATP binding site [chemical binding]; other site 288705004452 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 288705004453 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 288705004454 catalytic triad [active] 288705004455 conserved cis-peptide bond; other site 288705004456 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 288705004457 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 288705004458 glutaminase active site [active] 288705004459 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 288705004460 dimer interface [polypeptide binding]; other site 288705004461 active site 288705004462 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 288705004463 dimer interface [polypeptide binding]; other site 288705004464 active site 288705004465 pantothenate kinase; Provisional; Region: PRK05439 288705004466 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 288705004467 ATP-binding site [chemical binding]; other site 288705004468 CoA-binding site [chemical binding]; other site 288705004469 Mg2+-binding site [ion binding]; other site 288705004470 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 288705004471 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 288705004472 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 288705004473 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 288705004474 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 288705004475 active site 288705004476 substrate binding site [chemical binding]; other site 288705004477 metal binding site [ion binding]; metal-binding site 288705004478 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 288705004479 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 288705004480 23S rRNA interface [nucleotide binding]; other site 288705004481 L3 interface [polypeptide binding]; other site 288705004482 FtsX-like permease family; Region: FtsX; pfam02687 288705004483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705004484 Transposase; Region: HTH_Tnp_1; cl17663 288705004485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 288705004486 HTH-like domain; Region: HTH_21; pfam13276 288705004487 Integrase core domain; Region: rve; pfam00665 288705004488 Integrase core domain; Region: rve_3; pfam13683 288705004489 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 288705004490 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288705004491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288705004492 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288705004493 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 288705004494 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 288705004495 active site 288705004496 tetramer interface; other site 288705004497 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 288705004498 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 288705004499 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 288705004500 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 288705004501 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 288705004502 DEAD-like helicases superfamily; Region: DEXDc; smart00487 288705004503 Part of AAA domain; Region: AAA_19; pfam13245 288705004504 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 288705004505 GMP synthase; Reviewed; Region: guaA; PRK00074 288705004506 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 288705004507 AMP/PPi binding site [chemical binding]; other site 288705004508 candidate oxyanion hole; other site 288705004509 catalytic triad [active] 288705004510 potential glutamine specificity residues [chemical binding]; other site 288705004511 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 288705004512 ATP Binding subdomain [chemical binding]; other site 288705004513 Ligand Binding sites [chemical binding]; other site 288705004514 Dimerization subdomain; other site 288705004515 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 288705004516 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 288705004517 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288705004518 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705004519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705004520 Q-loop/lid; other site 288705004521 ABC transporter signature motif; other site 288705004522 Walker B; other site 288705004523 D-loop; other site 288705004524 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705004525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705004526 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288705004527 Walker A/P-loop; other site 288705004528 ATP binding site [chemical binding]; other site 288705004529 Q-loop/lid; other site 288705004530 ABC transporter signature motif; other site 288705004531 Walker B; other site 288705004532 D-loop; other site 288705004533 H-loop/switch region; other site 288705004534 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 288705004535 active site 288705004536 phosphorylation site [posttranslational modification] 288705004537 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 288705004538 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 288705004539 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 288705004540 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 288705004541 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 288705004542 active site 288705004543 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 288705004544 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 288705004545 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 288705004546 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 288705004547 active site 288705004548 Domain of unknown function (DUF389); Region: DUF389; pfam04087 288705004549 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 288705004550 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 288705004551 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 288705004552 ring oligomerisation interface [polypeptide binding]; other site 288705004553 ATP/Mg binding site [chemical binding]; other site 288705004554 stacking interactions; other site 288705004555 hinge regions; other site 288705004556 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 288705004557 oligomerisation interface [polypeptide binding]; other site 288705004558 mobile loop; other site 288705004559 roof hairpin; other site 288705004560 putative transposase OrfB; Reviewed; Region: PHA02517 288705004561 HTH-like domain; Region: HTH_21; pfam13276 288705004562 Integrase core domain; Region: rve; pfam00665 288705004563 Integrase core domain; Region: rve_3; pfam13683 288705004564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705004565 Transposase; Region: HTH_Tnp_1; cl17663 288705004566 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 288705004567 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 288705004568 Walker A/P-loop; other site 288705004569 ATP binding site [chemical binding]; other site 288705004570 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 288705004571 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 288705004572 ABC transporter signature motif; other site 288705004573 Walker B; other site 288705004574 D-loop; other site 288705004575 H-loop/switch region; other site 288705004576 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 288705004577 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 288705004578 DNA binding site [nucleotide binding] 288705004579 catalytic residue [active] 288705004580 H2TH interface [polypeptide binding]; other site 288705004581 putative catalytic residues [active] 288705004582 turnover-facilitating residue; other site 288705004583 intercalation triad [nucleotide binding]; other site 288705004584 8OG recognition residue [nucleotide binding]; other site 288705004585 putative reading head residues; other site 288705004586 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 288705004587 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 288705004588 ribonuclease III; Reviewed; Region: rnc; PRK00102 288705004589 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 288705004590 dimerization interface [polypeptide binding]; other site 288705004591 active site 288705004592 metal binding site [ion binding]; metal-binding site 288705004593 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 288705004594 dsRNA binding site [nucleotide binding]; other site 288705004595 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 288705004596 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 288705004597 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 288705004598 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 288705004599 active site 288705004600 (T/H)XGH motif; other site 288705004601 aminotransferase; Validated; Region: PRK07777 288705004602 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288705004603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705004604 homodimer interface [polypeptide binding]; other site 288705004605 catalytic residue [active] 288705004606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 288705004607 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 288705004608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705004609 S-adenosylmethionine binding site [chemical binding]; other site 288705004610 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 288705004611 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 288705004612 generic binding surface II; other site 288705004613 ssDNA binding site; other site 288705004614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288705004615 ATP binding site [chemical binding]; other site 288705004616 putative Mg++ binding site [ion binding]; other site 288705004617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 288705004618 nucleotide binding region [chemical binding]; other site 288705004619 ATP-binding site [chemical binding]; other site 288705004620 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 288705004621 DAK2 domain; Region: Dak2; pfam02734 288705004622 thiamine monophosphate kinase; Provisional; Region: PRK05731 288705004623 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 288705004624 ATP binding site [chemical binding]; other site 288705004625 dimerization interface [polypeptide binding]; other site 288705004626 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 288705004627 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 288705004628 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 288705004629 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 288705004630 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 288705004631 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 288705004632 putative acyl-acceptor binding pocket; other site 288705004633 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 288705004634 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 288705004635 hinge; other site 288705004636 active site 288705004637 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 288705004638 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 288705004639 substrate binding site [chemical binding]; other site 288705004640 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 288705004641 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 288705004642 substrate binding site [chemical binding]; other site 288705004643 ligand binding site [chemical binding]; other site 288705004644 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 288705004645 Transcriptional regulator [Transcription]; Region: IclR; COG1414 288705004646 Bacterial transcriptional regulator; Region: IclR; pfam01614 288705004647 Protein of unknown function (DUF805); Region: DUF805; pfam05656 288705004648 RibD C-terminal domain; Region: RibD_C; cl17279 288705004649 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 288705004650 putative transposase OrfB; Reviewed; Region: PHA02517 288705004651 HTH-like domain; Region: HTH_21; pfam13276 288705004652 Integrase core domain; Region: rve; pfam00665 288705004653 Integrase core domain; Region: rve_3; pfam13683 288705004654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705004655 Transposase; Region: HTH_Tnp_1; cl17663 288705004656 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 288705004657 active site 288705004658 catalytic site [active] 288705004659 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 288705004660 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288705004661 active site 288705004662 ATP binding site [chemical binding]; other site 288705004663 activation loop (A-loop); other site 288705004664 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288705004665 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288705004666 putative DNA binding site [nucleotide binding]; other site 288705004667 dimerization interface [polypeptide binding]; other site 288705004668 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 288705004669 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 288705004670 putative Zn2+ binding site [ion binding]; other site 288705004671 hypothetical protein; Provisional; Region: PRK06062 288705004672 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288705004673 inhibitor-cofactor binding pocket; inhibition site 288705004674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705004675 catalytic residue [active] 288705004676 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 288705004677 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 288705004678 tetrameric interface [polypeptide binding]; other site 288705004679 NAD binding site [chemical binding]; other site 288705004680 catalytic residues [active] 288705004681 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 288705004682 CGNR zinc finger; Region: zf-CGNR; pfam11706 288705004683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705004684 classical (c) SDRs; Region: SDR_c; cd05233 288705004685 NAD(P) binding site [chemical binding]; other site 288705004686 active site 288705004687 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 288705004688 active site 288705004689 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 288705004690 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 288705004691 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 288705004692 active site 288705004693 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 288705004694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705004695 DNA-binding site [nucleotide binding]; DNA binding site 288705004696 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 288705004697 FCD domain; Region: FCD; pfam07729 288705004698 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 288705004699 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 288705004700 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 288705004701 NADP binding site [chemical binding]; other site 288705004702 catalytic residues [active] 288705004703 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 288705004704 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 288705004705 hydroxyglutarate oxidase; Provisional; Region: PRK11728 288705004706 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 288705004707 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 288705004708 Proline racemase; Region: Pro_racemase; pfam05544 288705004709 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 288705004710 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 288705004711 inhibitor site; inhibition site 288705004712 active site 288705004713 dimer interface [polypeptide binding]; other site 288705004714 catalytic residue [active] 288705004715 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 288705004716 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 288705004717 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 288705004718 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288705004719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288705004720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705004721 putative substrate translocation pore; other site 288705004722 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288705004723 argininosuccinate lyase; Provisional; Region: PRK06705 288705004724 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 288705004725 tetramer interface [polypeptide binding]; other site 288705004726 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288705004727 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 288705004728 dimer interface [polypeptide binding]; other site 288705004729 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288705004730 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 288705004731 Bacterial transcriptional regulator; Region: IclR; pfam01614 288705004732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288705004733 salt bridge; other site 288705004734 non-specific DNA binding site [nucleotide binding]; other site 288705004735 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288705004736 sequence-specific DNA binding site [nucleotide binding]; other site 288705004737 Predicted transcriptional regulators [Transcription]; Region: COG1733 288705004738 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 288705004739 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 288705004740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705004741 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 288705004742 NAD(P) binding site [chemical binding]; other site 288705004743 active site 288705004744 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 288705004745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705004746 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288705004747 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 288705004748 putative NAD(P) binding site [chemical binding]; other site 288705004749 ABC1 family; Region: ABC1; cl17513 288705004750 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 288705004751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705004752 Transposase; Region: HTH_Tnp_1; cl17663 288705004753 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 288705004754 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 288705004755 acyl-activating enzyme (AAE) consensus motif; other site 288705004756 AMP binding site [chemical binding]; other site 288705004757 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 288705004758 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 288705004759 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 288705004760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705004761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705004762 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 288705004763 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 288705004764 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288705004765 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 288705004766 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705004767 acyl-coenzyme A oxidase; Region: PLN02526 288705004768 active site 288705004769 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705004770 AMP-binding enzyme; Region: AMP-binding; pfam00501 288705004771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705004772 acyl-activating enzyme (AAE) consensus motif; other site 288705004773 AMP binding site [chemical binding]; other site 288705004774 active site 288705004775 CoA binding site [chemical binding]; other site 288705004776 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288705004777 MarR family; Region: MarR_2; pfam12802 288705004778 MarR family; Region: MarR_2; cl17246 288705004779 enoyl-CoA hydratase; Provisional; Region: PRK05862 288705004780 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288705004781 substrate binding site [chemical binding]; other site 288705004782 oxyanion hole (OAH) forming residues; other site 288705004783 trimer interface [polypeptide binding]; other site 288705004784 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 288705004785 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 288705004786 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 288705004787 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288705004788 substrate binding site [chemical binding]; other site 288705004789 oxyanion hole (OAH) forming residues; other site 288705004790 trimer interface [polypeptide binding]; other site 288705004791 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 288705004792 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 288705004793 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 288705004794 tetrameric interface [polypeptide binding]; other site 288705004795 NAD binding site [chemical binding]; other site 288705004796 catalytic residues [active] 288705004797 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 288705004798 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 288705004799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288705004800 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288705004801 Cupin domain; Region: Cupin_2; pfam07883 288705004802 LssY C-terminus; Region: LssY_C; pfam14067 288705004803 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 288705004804 ATP binding site [chemical binding]; other site 288705004805 active site 288705004806 substrate binding site [chemical binding]; other site 288705004807 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 288705004808 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 288705004809 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 288705004810 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 288705004811 L-asparaginase II; Region: Asparaginase_II; pfam06089 288705004812 amidophosphoribosyltransferase; Provisional; Region: PRK07847 288705004813 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 288705004814 active site 288705004815 tetramer interface [polypeptide binding]; other site 288705004816 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288705004817 active site 288705004818 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 288705004819 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 288705004820 dimerization interface [polypeptide binding]; other site 288705004821 putative ATP binding site [chemical binding]; other site 288705004822 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 288705004823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 288705004824 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 288705004825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288705004826 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 288705004827 Septum formation; Region: Septum_form; pfam13845 288705004828 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 288705004829 Clp amino terminal domain; Region: Clp_N; pfam02861 288705004830 Clp amino terminal domain; Region: Clp_N; pfam02861 288705004831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705004832 Walker A motif; other site 288705004833 ATP binding site [chemical binding]; other site 288705004834 Walker B motif; other site 288705004835 arginine finger; other site 288705004836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705004837 Walker A motif; other site 288705004838 ATP binding site [chemical binding]; other site 288705004839 Walker B motif; other site 288705004840 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 288705004841 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 288705004842 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 288705004843 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 288705004844 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 288705004845 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 288705004846 G1 box; other site 288705004847 GTP/Mg2+ binding site [chemical binding]; other site 288705004848 G2 box; other site 288705004849 Switch I region; other site 288705004850 G3 box; other site 288705004851 Switch II region; other site 288705004852 G4 box; other site 288705004853 G5 box; other site 288705004854 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 288705004855 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 288705004856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 288705004857 hypothetical protein; Provisional; Region: PRK11770 288705004858 Domain of unknown function (DUF307); Region: DUF307; pfam03733 288705004859 Domain of unknown function (DUF307); Region: DUF307; pfam03733 288705004860 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 288705004861 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288705004862 putative dimer interface [polypeptide binding]; other site 288705004863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288705004864 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288705004865 active site 288705004866 catalytic tetrad [active] 288705004867 Beta-lactamase; Region: Beta-lactamase; pfam00144 288705004868 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288705004869 amino acid transporter; Region: 2A0306; TIGR00909 288705004870 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 288705004871 HutD; Region: HutD; pfam05962 288705004872 AAA domain; Region: AAA_17; cl17253 288705004873 AAA domain; Region: AAA_18; pfam13238 288705004874 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 288705004875 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 288705004876 Na binding site [ion binding]; other site 288705004877 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 288705004878 DEAD-like helicases superfamily; Region: DEXDc; smart00487 288705004879 ATP binding site [chemical binding]; other site 288705004880 Mg++ binding site [ion binding]; other site 288705004881 motif III; other site 288705004882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705004883 nucleotide binding region [chemical binding]; other site 288705004884 ATP-binding site [chemical binding]; other site 288705004885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705004886 S-adenosylmethionine binding site [chemical binding]; other site 288705004887 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 288705004888 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 288705004889 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 288705004890 putative catalytic site [active] 288705004891 putative metal binding site [ion binding]; other site 288705004892 putative phosphate binding site [ion binding]; other site 288705004893 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 288705004894 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 288705004895 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 288705004896 Walker A/P-loop; other site 288705004897 ATP binding site [chemical binding]; other site 288705004898 Q-loop/lid; other site 288705004899 ABC transporter signature motif; other site 288705004900 Walker B; other site 288705004901 D-loop; other site 288705004902 H-loop/switch region; other site 288705004903 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 288705004904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705004905 dimer interface [polypeptide binding]; other site 288705004906 conserved gate region; other site 288705004907 ABC-ATPase subunit interface; other site 288705004908 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 288705004909 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 288705004910 cleavage site 288705004911 active site 288705004912 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 288705004913 active site 288705004914 substrate binding sites [chemical binding]; other site 288705004915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705004916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705004917 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 288705004918 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288705004919 DNA binding residues [nucleotide binding] 288705004920 putative dimer interface [polypeptide binding]; other site 288705004921 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 288705004922 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 288705004923 HSP70 interaction site [polypeptide binding]; other site 288705004924 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 288705004925 dimer interface [polypeptide binding]; other site 288705004926 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 288705004927 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 288705004928 dimer interface [polypeptide binding]; other site 288705004929 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 288705004930 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 288705004931 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 288705004932 nucleotide binding site [chemical binding]; other site 288705004933 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 288705004934 Protein export membrane protein; Region: SecD_SecF; cl14618 288705004935 malate:quinone oxidoreductase; Validated; Region: PRK05257 288705004936 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 288705004937 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 288705004938 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 288705004939 peptide binding site [polypeptide binding]; other site 288705004940 putative transposase OrfB; Reviewed; Region: PHA02517 288705004941 HTH-like domain; Region: HTH_21; pfam13276 288705004942 Integrase core domain; Region: rve; pfam00665 288705004943 Integrase core domain; Region: rve_3; pfam13683 288705004944 Transposase; Region: HTH_Tnp_1; cl17663 288705004945 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 288705004946 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 288705004947 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 288705004948 catalytic residues [active] 288705004949 catalytic nucleophile [active] 288705004950 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 288705004951 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 288705004952 GTPase Era; Reviewed; Region: era; PRK00089 288705004953 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 288705004954 G1 box; other site 288705004955 GTP/Mg2+ binding site [chemical binding]; other site 288705004956 Switch I region; other site 288705004957 G2 box; other site 288705004958 Switch II region; other site 288705004959 G3 box; other site 288705004960 G4 box; other site 288705004961 G5 box; other site 288705004962 KH domain; Region: KH_2; pfam07650 288705004963 Domain of unknown function DUF21; Region: DUF21; pfam01595 288705004964 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 288705004965 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 288705004966 Transporter associated domain; Region: CorC_HlyC; smart01091 288705004967 metal-binding heat shock protein; Provisional; Region: PRK00016 288705004968 PhoH-like protein; Region: PhoH; pfam02562 288705004969 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 288705004970 PhoH-like protein; Region: PhoH; cl17668 288705004971 Sporulation and spore germination; Region: Germane; pfam10646 288705004972 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 288705004973 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 288705004974 RNA methyltransferase, RsmE family; Region: TIGR00046 288705004975 chaperone protein DnaJ; Provisional; Region: PRK14278 288705004976 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 288705004977 HSP70 interaction site [polypeptide binding]; other site 288705004978 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 288705004979 Zn binding sites [ion binding]; other site 288705004980 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 288705004981 dimer interface [polypeptide binding]; other site 288705004982 HrcA protein C terminal domain; Region: HrcA; pfam01628 288705004983 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 288705004984 Tic20-like protein; Region: Tic20; pfam09685 288705004985 coproporphyrinogen III oxidase; Validated; Region: PRK05628 288705004986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288705004987 FeS/SAM binding site; other site 288705004988 GTP-binding protein LepA; Provisional; Region: PRK05433 288705004989 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 288705004990 G1 box; other site 288705004991 putative GEF interaction site [polypeptide binding]; other site 288705004992 GTP/Mg2+ binding site [chemical binding]; other site 288705004993 Switch I region; other site 288705004994 G2 box; other site 288705004995 G3 box; other site 288705004996 Switch II region; other site 288705004997 G4 box; other site 288705004998 G5 box; other site 288705004999 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 288705005000 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 288705005001 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 288705005002 PemK-like protein; Region: PemK; pfam02452 288705005003 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 288705005004 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 288705005005 catalytic triad [active] 288705005006 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 288705005007 substrate binding pocket [chemical binding]; other site 288705005008 hypothetical protein; Reviewed; Region: PRK07914 288705005009 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 288705005010 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 288705005011 Competence protein; Region: Competence; pfam03772 288705005012 SLBB domain; Region: SLBB; pfam10531 288705005013 comEA protein; Region: comE; TIGR01259 288705005014 Helix-hairpin-helix motif; Region: HHH; pfam00633 288705005015 EDD domain protein, DegV family; Region: DegV; TIGR00762 288705005016 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 288705005017 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 288705005018 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 288705005019 HIGH motif; other site 288705005020 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 288705005021 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 288705005022 active site 288705005023 KMSKS motif; other site 288705005024 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 288705005025 tRNA binding surface [nucleotide binding]; other site 288705005026 Proline dehydrogenase; Region: Pro_dh; cl03282 288705005027 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 288705005028 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288705005029 NAD(P) binding site [chemical binding]; other site 288705005030 catalytic residues [active] 288705005031 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 288705005032 amino acid transporter; Region: 2A0306; TIGR00909 288705005033 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 288705005034 short chain dehydrogenase; Provisional; Region: PRK06180 288705005035 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 288705005036 NADP binding site [chemical binding]; other site 288705005037 active site 288705005038 steroid binding site; other site 288705005039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705005040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705005041 glycerol kinase; Provisional; Region: glpK; PRK00047 288705005042 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 288705005043 N- and C-terminal domain interface [polypeptide binding]; other site 288705005044 active site 288705005045 MgATP binding site [chemical binding]; other site 288705005046 catalytic site [active] 288705005047 metal binding site [ion binding]; metal-binding site 288705005048 putative homotetramer interface [polypeptide binding]; other site 288705005049 glycerol binding site [chemical binding]; other site 288705005050 homodimer interface [polypeptide binding]; other site 288705005051 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 288705005052 amphipathic channel; other site 288705005053 Asn-Pro-Ala signature motifs; other site 288705005054 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 288705005055 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 288705005056 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 288705005057 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288705005058 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288705005059 active site 288705005060 catalytic tetrad [active] 288705005061 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288705005062 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 288705005063 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 288705005064 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288705005065 primosome assembly protein PriA; Provisional; Region: PRK14873 288705005066 S-adenosylmethionine synthetase; Validated; Region: PRK05250 288705005067 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 288705005068 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 288705005069 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 288705005070 Flavoprotein; Region: Flavoprotein; pfam02441 288705005071 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 288705005072 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 288705005073 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 288705005074 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 288705005075 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 288705005076 catalytic site [active] 288705005077 G-X2-G-X-G-K; other site 288705005078 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 288705005079 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 288705005080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705005081 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288705005082 putative substrate translocation pore; other site 288705005083 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 288705005084 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288705005085 ATP-grasp domain; Region: ATP-grasp_4; cl17255 288705005086 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 288705005087 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288705005088 ATP-grasp domain; Region: ATP-grasp_4; cl17255 288705005089 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 288705005090 IMP binding site; other site 288705005091 dimer interface [polypeptide binding]; other site 288705005092 interdomain contacts; other site 288705005093 partial ornithine binding site; other site 288705005094 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 288705005095 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 288705005096 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 288705005097 catalytic site [active] 288705005098 subunit interface [polypeptide binding]; other site 288705005099 dihydroorotase; Validated; Region: pyrC; PRK09357 288705005100 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 288705005101 active site 288705005102 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 288705005103 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 288705005104 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 288705005105 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 288705005106 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288705005107 active site 288705005108 Protease prsW family; Region: PrsW-protease; pfam13367 288705005109 transcription antitermination factor NusB; Region: nusB; TIGR01951 288705005110 putative RNA binding site [nucleotide binding]; other site 288705005111 elongation factor P; Validated; Region: PRK00529 288705005112 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 288705005113 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 288705005114 RNA binding site [nucleotide binding]; other site 288705005115 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 288705005116 RNA binding site [nucleotide binding]; other site 288705005117 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 288705005118 active site 288705005119 dimer interface [polypeptide binding]; other site 288705005120 metal binding site [ion binding]; metal-binding site 288705005121 shikimate kinase; Reviewed; Region: aroK; PRK00131 288705005122 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 288705005123 ADP binding site [chemical binding]; other site 288705005124 magnesium binding site [ion binding]; other site 288705005125 putative shikimate binding site; other site 288705005126 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 288705005127 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 288705005128 Tetramer interface [polypeptide binding]; other site 288705005129 active site 288705005130 FMN-binding site [chemical binding]; other site 288705005131 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 288705005132 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 288705005133 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 288705005134 shikimate binding site; other site 288705005135 NAD(P) binding site [chemical binding]; other site 288705005136 YceG-like family; Region: YceG; pfam02618 288705005137 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 288705005138 dimerization interface [polypeptide binding]; other site 288705005139 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 288705005140 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 288705005141 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 288705005142 motif 1; other site 288705005143 active site 288705005144 motif 2; other site 288705005145 motif 3; other site 288705005146 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 288705005147 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 288705005148 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 288705005149 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 288705005150 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288705005151 RNA binding surface [nucleotide binding]; other site 288705005152 recombination factor protein RarA; Reviewed; Region: PRK13342 288705005153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 288705005154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705005155 Walker A motif; other site 288705005156 ATP binding site [chemical binding]; other site 288705005157 Walker B motif; other site 288705005158 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 288705005159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705005160 Coenzyme A binding pocket [chemical binding]; other site 288705005161 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 288705005162 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 288705005163 dimer interface [polypeptide binding]; other site 288705005164 anticodon binding site; other site 288705005165 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 288705005166 motif 1; other site 288705005167 dimer interface [polypeptide binding]; other site 288705005168 active site 288705005169 motif 2; other site 288705005170 GAD domain; Region: GAD; pfam02938 288705005171 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 288705005172 active site 288705005173 motif 3; other site 288705005174 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 288705005175 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 288705005176 dimer interface [polypeptide binding]; other site 288705005177 motif 1; other site 288705005178 active site 288705005179 motif 2; other site 288705005180 motif 3; other site 288705005181 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 288705005182 anticodon binding site; other site 288705005183 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 288705005184 active site 288705005185 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 288705005186 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 288705005187 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 288705005188 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 288705005189 HD domain; Region: HD_4; pfam13328 288705005190 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 288705005191 synthetase active site [active] 288705005192 NTP binding site [chemical binding]; other site 288705005193 metal binding site [ion binding]; metal-binding site 288705005194 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 288705005195 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 288705005196 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 288705005197 Protein export membrane protein; Region: SecD_SecF; cl14618 288705005198 protein-export membrane protein SecD; Region: secD; TIGR01129 288705005199 Protein export membrane protein; Region: SecD_SecF; cl14618 288705005200 Preprotein translocase subunit; Region: YajC; pfam02699 288705005201 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 288705005202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705005203 Walker A motif; other site 288705005204 ATP binding site [chemical binding]; other site 288705005205 Walker B motif; other site 288705005206 arginine finger; other site 288705005207 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 288705005208 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 288705005209 RuvA N terminal domain; Region: RuvA_N; pfam01330 288705005210 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 288705005211 active site 288705005212 putative DNA-binding cleft [nucleotide binding]; other site 288705005213 dimer interface [polypeptide binding]; other site 288705005214 hypothetical protein; Validated; Region: PRK00110 288705005215 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 288705005216 predicted active site [active] 288705005217 catalytic triad [active] 288705005218 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 288705005219 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 288705005220 active site 288705005221 dimer interface [polypeptide binding]; other site 288705005222 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 288705005223 Ligand Binding Site [chemical binding]; other site 288705005224 Molecular Tunnel; other site 288705005225 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 288705005226 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 288705005227 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 288705005228 active site 288705005229 Zn binding site [ion binding]; other site 288705005230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705005231 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288705005232 Coenzyme A binding pocket [chemical binding]; other site 288705005233 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 288705005234 RibD C-terminal domain; Region: RibD_C; cl17279 288705005235 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 288705005236 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 288705005237 active site 288705005238 multimer interface [polypeptide binding]; other site 288705005239 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 288705005240 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 288705005241 nucleotide binding site/active site [active] 288705005242 HIT family signature motif; other site 288705005243 catalytic residue [active] 288705005244 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 288705005245 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 288705005246 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 288705005247 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 288705005248 active site 288705005249 dimer interface [polypeptide binding]; other site 288705005250 motif 1; other site 288705005251 motif 2; other site 288705005252 motif 3; other site 288705005253 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 288705005254 anticodon binding site; other site 288705005255 Transcriptional regulators [Transcription]; Region: FadR; COG2186 288705005256 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705005257 DNA-binding site [nucleotide binding]; DNA binding site 288705005258 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 288705005259 fructuronate transporter; Provisional; Region: PRK10034; cl15264 288705005260 GntP family permease; Region: GntP_permease; pfam02447 288705005261 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 288705005262 Shikimate kinase; Region: SKI; pfam01202 288705005263 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 288705005264 active site 288705005265 catalytic residues [active] 288705005266 metal binding site [ion binding]; metal-binding site 288705005267 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 288705005268 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 288705005269 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 288705005270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705005271 S-adenosylmethionine binding site [chemical binding]; other site 288705005272 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288705005273 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705005274 DNA-binding site [nucleotide binding]; DNA binding site 288705005275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288705005276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705005277 homodimer interface [polypeptide binding]; other site 288705005278 catalytic residue [active] 288705005279 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 288705005280 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 288705005281 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 288705005282 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 288705005283 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 288705005284 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 288705005285 Ligand binding site; other site 288705005286 Putative Catalytic site; other site 288705005287 DXD motif; other site 288705005288 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 288705005289 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 288705005290 active site 288705005291 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 288705005292 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288705005293 ATP binding site [chemical binding]; other site 288705005294 putative Mg++ binding site [ion binding]; other site 288705005295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705005296 nucleotide binding region [chemical binding]; other site 288705005297 ATP-binding site [chemical binding]; other site 288705005298 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 288705005299 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 288705005300 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 288705005301 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 288705005302 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 288705005303 WYL domain; Region: WYL; pfam13280 288705005304 Predicted transcriptional regulator [Transcription]; Region: COG2378 288705005305 WYL domain; Region: WYL; pfam13280 288705005306 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 288705005307 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 288705005308 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 288705005309 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 288705005310 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 288705005311 active site 288705005312 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 288705005313 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 288705005314 active site 288705005315 Pup-like protein; Region: Pup; pfam05639 288705005316 Pup-ligase protein; Region: Pup_ligase; cl15463 288705005317 proteasome ATPase; Region: pup_AAA; TIGR03689 288705005318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705005319 Walker A motif; other site 288705005320 ATP binding site [chemical binding]; other site 288705005321 Walker B motif; other site 288705005322 arginine finger; other site 288705005323 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 288705005324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705005325 S-adenosylmethionine binding site [chemical binding]; other site 288705005326 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 288705005327 active site 288705005328 Peptidase family M50; Region: Peptidase_M50; pfam02163 288705005329 putative substrate binding region [chemical binding]; other site 288705005330 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 288705005331 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 288705005332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288705005333 motif II; other site 288705005334 PAC2 family; Region: PAC2; pfam09754 288705005335 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 288705005336 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 288705005337 active site 288705005338 HIGH motif; other site 288705005339 nucleotide binding site [chemical binding]; other site 288705005340 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 288705005341 active site 288705005342 KMSKS motif; other site 288705005343 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 288705005344 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288705005345 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288705005346 active site 288705005347 catalytic tetrad [active] 288705005348 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705005349 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705005350 hypothetical protein; Provisional; Region: PRK07906 288705005351 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 288705005352 putative metal binding site [ion binding]; other site 288705005353 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 288705005354 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288705005355 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 288705005356 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 288705005357 putative sugar binding sites [chemical binding]; other site 288705005358 Q-X-W motif; other site 288705005359 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 288705005360 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 288705005361 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 288705005362 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288705005363 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 288705005364 intersubunit interface [polypeptide binding]; other site 288705005365 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 288705005366 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288705005367 dimer interface [polypeptide binding]; other site 288705005368 ABC-ATPase subunit interface; other site 288705005369 putative PBP binding regions; other site 288705005370 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288705005371 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288705005372 Walker A/P-loop; other site 288705005373 ATP binding site [chemical binding]; other site 288705005374 Q-loop/lid; other site 288705005375 ABC transporter signature motif; other site 288705005376 Walker B; other site 288705005377 D-loop; other site 288705005378 H-loop/switch region; other site 288705005379 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 288705005380 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 288705005381 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 288705005382 metal-binding site [ion binding] 288705005383 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288705005384 Soluble P-type ATPase [General function prediction only]; Region: COG4087 288705005385 Cytochrome P450; Region: p450; cl12078 288705005386 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 288705005387 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 288705005388 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705005389 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705005390 catalytic residue [active] 288705005391 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705005392 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 288705005393 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 288705005394 active site 2 [active] 288705005395 active site 1 [active] 288705005396 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 288705005397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705005398 NAD(P) binding site [chemical binding]; other site 288705005399 active site 288705005400 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 288705005401 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288705005402 dimer interface [polypeptide binding]; other site 288705005403 active site 288705005404 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705005405 acyl-coenzyme A oxidase; Region: PLN02636 288705005406 active site 288705005407 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 288705005408 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 288705005409 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705005410 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705005411 catalytic residue [active] 288705005412 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 288705005413 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 288705005414 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 288705005415 ligand binding site; other site 288705005416 oligomer interface; other site 288705005417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705005418 NAD(P) binding site [chemical binding]; other site 288705005419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705005420 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 288705005421 active site 288705005422 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 288705005423 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 288705005424 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 288705005425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 288705005426 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 288705005427 Uncharacterized conserved protein [Function unknown]; Region: COG2308 288705005428 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 288705005429 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 288705005430 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 288705005431 Peptidase family M1; Region: Peptidase_M1; pfam01433 288705005432 Zn binding site [ion binding]; other site 288705005433 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 288705005434 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 288705005435 homotrimer interaction site [polypeptide binding]; other site 288705005436 putative active site [active] 288705005437 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 288705005438 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 288705005439 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 288705005440 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 288705005441 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 288705005442 catalytic triad [active] 288705005443 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 288705005444 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 288705005445 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288705005446 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288705005447 phosphoserine phosphatase SerB; Region: serB; TIGR00338 288705005448 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 288705005449 short chain dehydrogenase; Provisional; Region: PRK07806 288705005450 NAD(P) binding site [chemical binding]; other site 288705005451 active site 288705005452 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 288705005453 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 288705005454 NAD(P) binding site [chemical binding]; other site 288705005455 homotetramer interface [polypeptide binding]; other site 288705005456 homodimer interface [polypeptide binding]; other site 288705005457 active site 288705005458 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 288705005459 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 288705005460 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 288705005461 putative deacylase active site [active] 288705005462 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288705005463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705005464 Walker A/P-loop; other site 288705005465 ATP binding site [chemical binding]; other site 288705005466 Q-loop/lid; other site 288705005467 ABC transporter signature motif; other site 288705005468 Walker B; other site 288705005469 D-loop; other site 288705005470 H-loop/switch region; other site 288705005471 ABC transporter; Region: ABC_tran_2; pfam12848 288705005472 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288705005473 TAP-like protein; Region: Abhydrolase_4; pfam08386 288705005474 BioY family; Region: BioY; pfam02632 288705005475 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 288705005476 Walker A/P-loop; other site 288705005477 ATP binding site [chemical binding]; other site 288705005478 ABC transporter; Region: ABC_tran; pfam00005 288705005479 Q-loop/lid; other site 288705005480 ABC transporter signature motif; other site 288705005481 Walker B; other site 288705005482 D-loop; other site 288705005483 H-loop/switch region; other site 288705005484 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 288705005485 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288705005486 dimer interface [polypeptide binding]; other site 288705005487 active site 288705005488 acyl-CoA synthetase; Validated; Region: PRK07638 288705005489 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 288705005490 acyl-activating enzyme (AAE) consensus motif; other site 288705005491 AMP binding site [chemical binding]; other site 288705005492 active site 288705005493 CoA binding site [chemical binding]; other site 288705005494 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 288705005495 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 288705005496 active site 288705005497 putative transposase OrfB; Reviewed; Region: PHA02517 288705005498 HTH-like domain; Region: HTH_21; pfam13276 288705005499 Integrase core domain; Region: rve; pfam00665 288705005500 Integrase core domain; Region: rve_3; pfam13683 288705005501 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 288705005502 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 288705005503 dimerization interface 3.5A [polypeptide binding]; other site 288705005504 active site 288705005505 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 288705005506 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 288705005507 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 288705005508 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 288705005509 alphaNTD homodimer interface [polypeptide binding]; other site 288705005510 alphaNTD - beta interaction site [polypeptide binding]; other site 288705005511 alphaNTD - beta' interaction site [polypeptide binding]; other site 288705005512 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 288705005513 30S ribosomal protein S11; Validated; Region: PRK05309 288705005514 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 288705005515 30S ribosomal protein S13; Region: bact_S13; TIGR03631 288705005516 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 288705005517 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 288705005518 rRNA binding site [nucleotide binding]; other site 288705005519 predicted 30S ribosome binding site; other site 288705005520 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 288705005521 putative active site pocket [active] 288705005522 cleavage site 288705005523 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 288705005524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705005525 dimer interface [polypeptide binding]; other site 288705005526 conserved gate region; other site 288705005527 putative PBP binding loops; other site 288705005528 ABC-ATPase subunit interface; other site 288705005529 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705005530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705005531 dimer interface [polypeptide binding]; other site 288705005532 conserved gate region; other site 288705005533 putative PBP binding loops; other site 288705005534 ABC-ATPase subunit interface; other site 288705005535 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 288705005536 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705005537 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 288705005538 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 288705005539 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 288705005540 active site 288705005541 Lipase (class 2); Region: Lipase_2; pfam01674 288705005542 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288705005543 acyl-coenzyme A oxidase; Region: PLN02526 288705005544 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705005545 active site 288705005546 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 288705005547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705005548 NAD(P) binding site [chemical binding]; other site 288705005549 active site 288705005550 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 288705005551 active site 2 [active] 288705005552 active site 1 [active] 288705005553 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 288705005554 active site 288705005555 catalytic site [active] 288705005556 lipid-transfer protein; Provisional; Region: PRK08256 288705005557 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 288705005558 active site 288705005559 lipid-transfer protein; Provisional; Region: PRK08256 288705005560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705005561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705005562 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705005563 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705005564 putative transposase OrfB; Reviewed; Region: PHA02517 288705005565 HTH-like domain; Region: HTH_21; pfam13276 288705005566 Integrase core domain; Region: rve; pfam00665 288705005567 Integrase core domain; Region: rve_3; pfam13683 288705005568 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705005569 Transposase; Region: HTH_Tnp_1; cl17663 288705005570 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705005571 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705005572 acyl-activating enzyme (AAE) consensus motif; other site 288705005573 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 288705005574 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 288705005575 CoA-transferase family III; Region: CoA_transf_3; pfam02515 288705005576 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288705005577 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288705005578 active site 288705005579 adenylate kinase; Reviewed; Region: adk; PRK00279 288705005580 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 288705005581 AMP-binding site [chemical binding]; other site 288705005582 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 288705005583 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 288705005584 SecY translocase; Region: SecY; pfam00344 288705005585 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 288705005586 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 288705005587 23S rRNA binding site [nucleotide binding]; other site 288705005588 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 288705005589 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 288705005590 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 288705005591 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 288705005592 5S rRNA interface [nucleotide binding]; other site 288705005593 L27 interface [polypeptide binding]; other site 288705005594 23S rRNA interface [nucleotide binding]; other site 288705005595 L5 interface [polypeptide binding]; other site 288705005596 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 288705005597 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 288705005598 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 288705005599 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 288705005600 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 288705005601 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 288705005602 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 288705005603 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 288705005604 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 288705005605 RNA binding site [nucleotide binding]; other site 288705005606 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 288705005607 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 288705005608 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 288705005609 Moco binding site; other site 288705005610 metal coordination site [ion binding]; other site 288705005611 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 288705005612 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 288705005613 putative translocon interaction site; other site 288705005614 23S rRNA interface [nucleotide binding]; other site 288705005615 signal recognition particle (SRP54) interaction site; other site 288705005616 L23 interface [polypeptide binding]; other site 288705005617 trigger factor interaction site; other site 288705005618 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 288705005619 23S rRNA interface [nucleotide binding]; other site 288705005620 5S rRNA interface [nucleotide binding]; other site 288705005621 putative antibiotic binding site [chemical binding]; other site 288705005622 L25 interface [polypeptide binding]; other site 288705005623 L27 interface [polypeptide binding]; other site 288705005624 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 288705005625 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 288705005626 G-X-X-G motif; other site 288705005627 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 288705005628 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 288705005629 putative translocon binding site; other site 288705005630 protein-rRNA interface [nucleotide binding]; other site 288705005631 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 288705005632 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 288705005633 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 288705005634 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 288705005635 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 288705005636 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 288705005637 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 288705005638 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 288705005639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705005640 elongation factor Tu; Reviewed; Region: PRK00049 288705005641 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 288705005642 G1 box; other site 288705005643 GEF interaction site [polypeptide binding]; other site 288705005644 GTP/Mg2+ binding site [chemical binding]; other site 288705005645 Switch I region; other site 288705005646 G2 box; other site 288705005647 G3 box; other site 288705005648 Switch II region; other site 288705005649 G4 box; other site 288705005650 G5 box; other site 288705005651 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 288705005652 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 288705005653 Antibiotic Binding Site [chemical binding]; other site 288705005654 elongation factor G; Reviewed; Region: PRK00007 288705005655 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 288705005656 G1 box; other site 288705005657 putative GEF interaction site [polypeptide binding]; other site 288705005658 GTP/Mg2+ binding site [chemical binding]; other site 288705005659 Switch I region; other site 288705005660 G2 box; other site 288705005661 G3 box; other site 288705005662 Switch II region; other site 288705005663 G4 box; other site 288705005664 G5 box; other site 288705005665 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 288705005666 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 288705005667 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 288705005668 30S ribosomal protein S7; Validated; Region: PRK05302 288705005669 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 288705005670 S17 interaction site [polypeptide binding]; other site 288705005671 S8 interaction site; other site 288705005672 16S rRNA interaction site [nucleotide binding]; other site 288705005673 streptomycin interaction site [chemical binding]; other site 288705005674 23S rRNA interaction site [nucleotide binding]; other site 288705005675 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 288705005676 fructuronate transporter; Provisional; Region: PRK10034; cl15264 288705005677 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 288705005678 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 288705005679 FAD dependent oxidoreductase; Region: DAO; pfam01266 288705005680 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288705005681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705005682 DNA-binding site [nucleotide binding]; DNA binding site 288705005683 UTRA domain; Region: UTRA; pfam07702 288705005684 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 288705005685 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288705005686 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 288705005687 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 288705005688 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288705005689 Soluble P-type ATPase [General function prediction only]; Region: COG4087 288705005690 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705005691 putative DNA binding site [nucleotide binding]; other site 288705005692 dimerization interface [polypeptide binding]; other site 288705005693 putative Zn2+ binding site [ion binding]; other site 288705005694 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 288705005695 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 288705005696 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 288705005697 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 288705005698 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 288705005699 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 288705005700 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 288705005701 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 288705005702 G-loop; other site 288705005703 DNA binding site [nucleotide binding] 288705005704 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 288705005705 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 288705005706 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 288705005707 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 288705005708 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 288705005709 RPB10 interaction site [polypeptide binding]; other site 288705005710 RPB1 interaction site [polypeptide binding]; other site 288705005711 RPB11 interaction site [polypeptide binding]; other site 288705005712 RPB3 interaction site [polypeptide binding]; other site 288705005713 RPB12 interaction site [polypeptide binding]; other site 288705005714 HSP90 family protein; Provisional; Region: PRK14083 288705005715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288705005716 ATP binding site [chemical binding]; other site 288705005717 Mg2+ binding site [ion binding]; other site 288705005718 G-X-G motif; other site 288705005719 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 288705005720 Short repeats of unknown function; Region: ALF; pfam03752 288705005721 Short repeats of unknown function; Region: ALF; pfam03752 288705005722 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 288705005723 Q-X-W motif; other site 288705005724 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 288705005725 putative acyltransferase; Provisional; Region: PRK05790 288705005726 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288705005727 dimer interface [polypeptide binding]; other site 288705005728 active site 288705005729 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 288705005730 putative deacylase active site [active] 288705005731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705005732 Transposase; Region: HTH_Tnp_1; cl17663 288705005733 putative transposase OrfB; Reviewed; Region: PHA02517 288705005734 HTH-like domain; Region: HTH_21; pfam13276 288705005735 Integrase core domain; Region: rve; pfam00665 288705005736 Integrase core domain; Region: rve_3; pfam13683 288705005737 Domain of unknown function DUF11; Region: DUF11; pfam01345 288705005738 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 288705005739 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 288705005740 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 288705005741 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 288705005742 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 288705005743 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 288705005744 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 288705005745 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 288705005746 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 288705005747 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 288705005748 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 288705005749 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 288705005750 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 288705005751 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 288705005752 trimer interface [polypeptide binding]; other site 288705005753 active site 288705005754 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 288705005755 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705005756 dimerization interface [polypeptide binding]; other site 288705005757 putative DNA binding site [nucleotide binding]; other site 288705005758 putative Zn2+ binding site [ion binding]; other site 288705005759 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 288705005760 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 288705005761 hydrophobic ligand binding site; other site 288705005762 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288705005763 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 288705005764 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 288705005765 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 288705005766 NAD binding site [chemical binding]; other site 288705005767 catalytic Zn binding site [ion binding]; other site 288705005768 substrate binding site [chemical binding]; other site 288705005769 structural Zn binding site [ion binding]; other site 288705005770 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288705005771 H+ Antiporter protein; Region: 2A0121; TIGR00900 288705005772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705005773 putative substrate translocation pore; other site 288705005774 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288705005775 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705005776 putative DNA binding site [nucleotide binding]; other site 288705005777 putative Zn2+ binding site [ion binding]; other site 288705005778 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288705005779 dimerization interface [polypeptide binding]; other site 288705005780 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 288705005781 tetramerization interface [polypeptide binding]; other site 288705005782 active site 288705005783 Predicted permeases [General function prediction only]; Region: COG0679 288705005784 Membrane transport protein; Region: Mem_trans; cl09117 288705005785 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 288705005786 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 288705005787 Ferritin-like domain; Region: Ferritin; pfam00210 288705005788 ferroxidase diiron center [ion binding]; other site 288705005789 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 288705005790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705005791 Transposase; Region: HTH_Tnp_1; cl17663 288705005792 putative transposase OrfB; Reviewed; Region: PHA02517 288705005793 HTH-like domain; Region: HTH_21; pfam13276 288705005794 Integrase core domain; Region: rve; pfam00665 288705005795 Integrase core domain; Region: rve_3; pfam13683 288705005796 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 288705005797 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 288705005798 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 288705005799 Walker A/P-loop; other site 288705005800 ATP binding site [chemical binding]; other site 288705005801 Q-loop/lid; other site 288705005802 ABC transporter signature motif; other site 288705005803 Walker B; other site 288705005804 D-loop; other site 288705005805 H-loop/switch region; other site 288705005806 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 288705005807 [2Fe-2S] cluster binding site [ion binding]; other site 288705005808 FeS assembly protein SufD; Region: sufD; TIGR01981 288705005809 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 288705005810 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 288705005811 FeS assembly protein SufB; Region: sufB; TIGR01980 288705005812 Predicted transcriptional regulator [Transcription]; Region: COG2345 288705005813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705005814 putative DNA binding site [nucleotide binding]; other site 288705005815 putative Zn2+ binding site [ion binding]; other site 288705005816 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 288705005817 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 288705005818 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288705005819 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 288705005820 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288705005821 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288705005822 Walker A/P-loop; other site 288705005823 ATP binding site [chemical binding]; other site 288705005824 Q-loop/lid; other site 288705005825 ABC transporter signature motif; other site 288705005826 Walker B; other site 288705005827 D-loop; other site 288705005828 H-loop/switch region; other site 288705005829 ABC-2 type transporter; Region: ABC2_membrane; cl17235 288705005830 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 288705005831 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 288705005832 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 288705005833 UbiA prenyltransferase family; Region: UbiA; pfam01040 288705005834 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 288705005835 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 288705005836 TPP-binding site [chemical binding]; other site 288705005837 dimer interface [polypeptide binding]; other site 288705005838 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 288705005839 PYR/PP interface [polypeptide binding]; other site 288705005840 dimer interface [polypeptide binding]; other site 288705005841 TPP binding site [chemical binding]; other site 288705005842 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288705005843 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 288705005844 putative active site [active] 288705005845 catalytic residue [active] 288705005846 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 288705005847 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 288705005848 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 288705005849 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 288705005850 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 288705005851 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 288705005852 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 288705005853 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 288705005854 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 288705005855 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 288705005856 putative active site [active] 288705005857 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 288705005858 triosephosphate isomerase; Provisional; Region: PRK14567 288705005859 substrate binding site [chemical binding]; other site 288705005860 dimer interface [polypeptide binding]; other site 288705005861 catalytic triad [active] 288705005862 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 288705005863 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288705005864 substrate binding pocket [chemical binding]; other site 288705005865 membrane-bound complex binding site; other site 288705005866 hinge residues; other site 288705005867 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288705005868 membrane-bound complex binding site; other site 288705005869 hinge residues; other site 288705005870 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288705005871 substrate binding pocket [chemical binding]; other site 288705005872 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288705005873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705005874 Q-loop/lid; other site 288705005875 ABC transporter signature motif; other site 288705005876 Walker B; other site 288705005877 D-loop; other site 288705005878 H-loop/switch region; other site 288705005879 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 288705005880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705005881 dimer interface [polypeptide binding]; other site 288705005882 conserved gate region; other site 288705005883 putative PBP binding loops; other site 288705005884 ABC-ATPase subunit interface; other site 288705005885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705005886 Coenzyme A binding pocket [chemical binding]; other site 288705005887 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 288705005888 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 288705005889 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 288705005890 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 288705005891 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 288705005892 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 288705005893 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 288705005894 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 288705005895 Phosphoglycerate kinase; Region: PGK; pfam00162 288705005896 substrate binding site [chemical binding]; other site 288705005897 hinge regions; other site 288705005898 ADP binding site [chemical binding]; other site 288705005899 catalytic site [active] 288705005900 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 288705005901 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 288705005902 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 288705005903 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 288705005904 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 288705005905 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 288705005906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 288705005907 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 288705005908 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 288705005909 phosphate binding site [ion binding]; other site 288705005910 putative substrate binding pocket [chemical binding]; other site 288705005911 dimer interface [polypeptide binding]; other site 288705005912 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 288705005913 AAA domain; Region: AAA_33; pfam13671 288705005914 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 288705005915 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 288705005916 GIY-YIG motif/motif A; other site 288705005917 active site 288705005918 catalytic site [active] 288705005919 putative DNA binding site [nucleotide binding]; other site 288705005920 metal binding site [ion binding]; metal-binding site 288705005921 UvrB/uvrC motif; Region: UVR; pfam02151 288705005922 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 288705005923 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 288705005924 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 288705005925 putative acyl-acceptor binding pocket; other site 288705005926 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288705005927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288705005928 motif II; other site 288705005929 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 288705005930 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 288705005931 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 288705005932 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 288705005933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705005934 DNA-binding site [nucleotide binding]; DNA binding site 288705005935 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705005936 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288705005937 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 288705005938 Walker A/P-loop; other site 288705005939 ATP binding site [chemical binding]; other site 288705005940 Q-loop/lid; other site 288705005941 ABC transporter signature motif; other site 288705005942 Walker B; other site 288705005943 D-loop; other site 288705005944 H-loop/switch region; other site 288705005945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705005946 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705005947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705005948 Walker A/P-loop; other site 288705005949 ATP binding site [chemical binding]; other site 288705005950 ABC transporter; Region: ABC_tran; pfam00005 288705005951 Q-loop/lid; other site 288705005952 ABC transporter signature motif; other site 288705005953 Walker B; other site 288705005954 D-loop; other site 288705005955 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288705005956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705005957 putative DNA binding site [nucleotide binding]; other site 288705005958 putative Zn2+ binding site [ion binding]; other site 288705005959 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 288705005960 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 288705005961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705005962 S-adenosylmethionine binding site [chemical binding]; other site 288705005963 DEAD-like helicases superfamily; Region: DEXDc; smart00487 288705005964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288705005965 ATP binding site [chemical binding]; other site 288705005966 putative Mg++ binding site [ion binding]; other site 288705005967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705005968 nucleotide binding region [chemical binding]; other site 288705005969 ATP-binding site [chemical binding]; other site 288705005970 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 288705005971 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 288705005972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705005973 Coenzyme A binding pocket [chemical binding]; other site 288705005974 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 288705005975 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 288705005976 excinuclease ABC subunit B; Provisional; Region: PRK05298 288705005977 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288705005978 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705005979 nucleotide binding region [chemical binding]; other site 288705005980 ATP-binding site [chemical binding]; other site 288705005981 Ultra-violet resistance protein B; Region: UvrB; pfam12344 288705005982 UvrB/uvrC motif; Region: UVR; pfam02151 288705005983 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 288705005984 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 288705005985 CoA-binding site [chemical binding]; other site 288705005986 ATP-binding [chemical binding]; other site 288705005987 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 288705005988 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 288705005989 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 288705005990 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 288705005991 RNA binding site [nucleotide binding]; other site 288705005992 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 288705005993 RNA binding site [nucleotide binding]; other site 288705005994 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288705005995 RNA binding site [nucleotide binding]; other site 288705005996 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 288705005997 RNA binding site [nucleotide binding]; other site 288705005998 domain interface; other site 288705005999 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 288705006000 oxidoreductase; Provisional; Region: PRK06196 288705006001 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 288705006002 putative NAD(P) binding site [chemical binding]; other site 288705006003 active site 288705006004 DNA polymerase I; Provisional; Region: PRK05755 288705006005 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 288705006006 active site 288705006007 metal binding site 1 [ion binding]; metal-binding site 288705006008 putative 5' ssDNA interaction site; other site 288705006009 metal binding site 3; metal-binding site 288705006010 metal binding site 2 [ion binding]; metal-binding site 288705006011 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 288705006012 putative DNA binding site [nucleotide binding]; other site 288705006013 putative metal binding site [ion binding]; other site 288705006014 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 288705006015 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 288705006016 active site 288705006017 DNA binding site [nucleotide binding] 288705006018 catalytic site [active] 288705006019 Phosphate transporter family; Region: PHO4; pfam01384 288705006020 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 288705006021 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 288705006022 CoenzymeA binding site [chemical binding]; other site 288705006023 subunit interaction site [polypeptide binding]; other site 288705006024 PHB binding site; other site 288705006025 topology modulation protein; Reviewed; Region: PRK08118 288705006026 AAA domain; Region: AAA_17; pfam13207 288705006027 RibD C-terminal domain; Region: RibD_C; cl17279 288705006028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705006029 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288705006030 putative substrate translocation pore; other site 288705006031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705006032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705006033 Transposase; Region: HTH_Tnp_1; cl17663 288705006034 putative transposase OrfB; Reviewed; Region: PHA02517 288705006035 HTH-like domain; Region: HTH_21; pfam13276 288705006036 Integrase core domain; Region: rve; pfam00665 288705006037 Integrase core domain; Region: rve_3; pfam13683 288705006038 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 288705006039 NAD(P) binding site [chemical binding]; other site 288705006040 catalytic residues [active] 288705006041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705006042 active site 288705006043 amidase; Provisional; Region: PRK07042 288705006044 Amidase; Region: Amidase; cl11426 288705006045 Amidase; Region: Amidase; cl11426 288705006046 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 288705006047 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288705006048 Walker A/P-loop; other site 288705006049 ATP binding site [chemical binding]; other site 288705006050 Q-loop/lid; other site 288705006051 ABC transporter signature motif; other site 288705006052 Walker B; other site 288705006053 D-loop; other site 288705006054 H-loop/switch region; other site 288705006055 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288705006056 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 288705006057 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288705006058 Walker A/P-loop; other site 288705006059 ATP binding site [chemical binding]; other site 288705006060 Q-loop/lid; other site 288705006061 ABC transporter signature motif; other site 288705006062 Walker B; other site 288705006063 D-loop; other site 288705006064 H-loop/switch region; other site 288705006065 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288705006066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705006067 dimer interface [polypeptide binding]; other site 288705006068 conserved gate region; other site 288705006069 putative PBP binding loops; other site 288705006070 ABC-ATPase subunit interface; other site 288705006071 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288705006072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705006073 dimer interface [polypeptide binding]; other site 288705006074 conserved gate region; other site 288705006075 putative PBP binding loops; other site 288705006076 ABC-ATPase subunit interface; other site 288705006077 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 288705006078 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 288705006079 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 288705006080 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 288705006081 Transcriptional regulators [Transcription]; Region: FadR; COG2186 288705006082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705006083 DNA-binding site [nucleotide binding]; DNA binding site 288705006084 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 288705006085 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 288705006086 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 288705006087 putative active site [active] 288705006088 putative FMN binding site [chemical binding]; other site 288705006089 putative substrate binding site [chemical binding]; other site 288705006090 putative catalytic residue [active] 288705006091 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 288705006092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705006093 active site 288705006094 phosphorylation site [posttranslational modification] 288705006095 intermolecular recognition site; other site 288705006096 dimerization interface [polypeptide binding]; other site 288705006097 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 288705006098 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 288705006099 pyruvate kinase; Provisional; Region: PRK06247 288705006100 domain interfaces; other site 288705006101 active site 288705006102 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 288705006103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288705006104 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 288705006105 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 288705006106 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 288705006107 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 288705006108 active site 288705006109 FMN binding site [chemical binding]; other site 288705006110 substrate binding site [chemical binding]; other site 288705006111 3Fe-4S cluster binding site [ion binding]; other site 288705006112 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 288705006113 domain interface; other site 288705006114 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 288705006115 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 288705006116 active site 288705006117 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 288705006118 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 288705006119 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 288705006120 substrate binding site [chemical binding]; other site 288705006121 active site 288705006122 catalytic residues [active] 288705006123 heterodimer interface [polypeptide binding]; other site 288705006124 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 288705006125 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 288705006126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705006127 catalytic residue [active] 288705006128 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 288705006129 active site 288705006130 ribulose/triose binding site [chemical binding]; other site 288705006131 phosphate binding site [ion binding]; other site 288705006132 substrate (anthranilate) binding pocket [chemical binding]; other site 288705006133 product (indole) binding pocket [chemical binding]; other site 288705006134 anthranilate synthase component I; Provisional; Region: PRK13571 288705006135 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 288705006136 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 288705006137 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 288705006138 TIGR03085 family protein; Region: TIGR03085 288705006139 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 288705006140 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 288705006141 substrate binding site [chemical binding]; other site 288705006142 glutamase interaction surface [polypeptide binding]; other site 288705006143 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 288705006144 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 288705006145 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 288705006146 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 288705006147 homodimer interface [polypeptide binding]; other site 288705006148 putative metal binding site [ion binding]; other site 288705006149 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 288705006150 active site 288705006151 homopentamer interface [polypeptide binding]; other site 288705006152 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 288705006153 dimerization interface [polypeptide binding]; other site 288705006154 active site 288705006155 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 288705006156 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 288705006157 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 288705006158 Lumazine binding domain; Region: Lum_binding; pfam00677 288705006159 Lumazine binding domain; Region: Lum_binding; pfam00677 288705006160 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 288705006161 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 288705006162 catalytic motif [active] 288705006163 Zn binding site [ion binding]; other site 288705006164 RibD C-terminal domain; Region: RibD_C; pfam01872 288705006165 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 288705006166 Epoxide hydrolase N terminus; Region: EHN; pfam06441 288705006167 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288705006168 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 288705006169 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 288705006170 substrate binding site [chemical binding]; other site 288705006171 hexamer interface [polypeptide binding]; other site 288705006172 metal binding site [ion binding]; metal-binding site 288705006173 16S rRNA methyltransferase B; Provisional; Region: PRK14902 288705006174 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 288705006175 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 288705006176 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 288705006177 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 288705006178 putative active site [active] 288705006179 substrate binding site [chemical binding]; other site 288705006180 putative cosubstrate binding site; other site 288705006181 catalytic site [active] 288705006182 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 288705006183 substrate binding site [chemical binding]; other site 288705006184 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 288705006185 active site 288705006186 catalytic residues [active] 288705006187 metal binding site [ion binding]; metal-binding site 288705006188 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 288705006189 Dienelactone hydrolase family; Region: DLH; pfam01738 288705006190 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 288705006191 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288705006192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705006193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705006194 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 288705006195 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 288705006196 benzoate transporter; Region: benE; TIGR00843 288705006197 benzoate transporter; Region: benE; TIGR00843 288705006198 Predicted ATPase [General function prediction only]; Region: COG1485 288705006199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 288705006200 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 288705006201 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 288705006202 active site residue [active] 288705006203 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 288705006204 active site residue [active] 288705006205 Fe-S metabolism associated domain; Region: SufE; cl00951 288705006206 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288705006207 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288705006208 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 288705006209 SelR domain; Region: SelR; pfam01641 288705006210 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 288705006211 nucleotide binding site/active site [active] 288705006212 HIT family signature motif; other site 288705006213 catalytic residue [active] 288705006214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705006215 active site 288705006216 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 288705006217 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 288705006218 tetramer interface [polypeptide binding]; other site 288705006219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705006220 catalytic residue [active] 288705006221 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 288705006222 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 288705006223 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 288705006224 catalytic site [active] 288705006225 putative active site [active] 288705006226 putative substrate binding site [chemical binding]; other site 288705006227 HRDC domain; Region: HRDC; pfam00570 288705006228 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288705006229 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 288705006230 dimer interface [polypeptide binding]; other site 288705006231 active site 288705006232 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288705006233 substrate binding site [chemical binding]; other site 288705006234 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 288705006235 oxyanion hole (OAH) forming residues; other site 288705006236 trimer interface [polypeptide binding]; other site 288705006237 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 288705006238 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288705006239 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288705006240 Response regulator receiver domain; Region: Response_reg; pfam00072 288705006241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705006242 active site 288705006243 phosphorylation site [posttranslational modification] 288705006244 intermolecular recognition site; other site 288705006245 dimerization interface [polypeptide binding]; other site 288705006246 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 288705006247 PAS domain; Region: PAS; smart00091 288705006248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288705006249 ATP binding site [chemical binding]; other site 288705006250 Mg2+ binding site [ion binding]; other site 288705006251 G-X-G motif; other site 288705006252 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 288705006253 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 288705006254 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288705006255 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288705006256 catalytic tetrad [active] 288705006257 Protein of unknown function (DUF402); Region: DUF402; pfam04167 288705006258 Protein of unknown function (DUF402); Region: DUF402; cl00979 288705006259 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 288705006260 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 288705006261 TPP-binding site [chemical binding]; other site 288705006262 TPP-binding site [chemical binding]; other site 288705006263 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 288705006264 PYR/PP interface [polypeptide binding]; other site 288705006265 dimer interface [polypeptide binding]; other site 288705006266 TPP binding site [chemical binding]; other site 288705006267 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288705006268 aconitate hydratase; Validated; Region: PRK09277 288705006269 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 288705006270 substrate binding site [chemical binding]; other site 288705006271 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 288705006272 ligand binding site [chemical binding]; other site 288705006273 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 288705006274 substrate binding site [chemical binding]; other site 288705006275 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 288705006276 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288705006277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288705006278 motif II; other site 288705006279 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 288705006280 heterodimer interface [polypeptide binding]; other site 288705006281 homodimer interface [polypeptide binding]; other site 288705006282 Domain of unknown function (DUF222); Region: DUF222; pfam02720 288705006283 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 288705006284 active site 288705006285 TRAM domain; Region: TRAM; cl01282 288705006286 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 288705006287 Amino acid permease; Region: AA_permease_2; pfam13520 288705006288 putative transposase OrfB; Reviewed; Region: PHA02517 288705006289 HTH-like domain; Region: HTH_21; pfam13276 288705006290 Integrase core domain; Region: rve; pfam00665 288705006291 Integrase core domain; Region: rve_3; pfam13683 288705006292 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 288705006293 TrkA-N domain; Region: TrkA_N; pfam02254 288705006294 TrkA-C domain; Region: TrkA_C; pfam02080 288705006295 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 288705006296 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 288705006297 generic binding surface I; other site 288705006298 generic binding surface II; other site 288705006299 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 288705006300 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 288705006301 trimer interface [polypeptide binding]; other site 288705006302 active site 288705006303 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 288705006304 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 288705006305 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 288705006306 thymidine kinase; Provisional; Region: PRK04296 288705006307 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 288705006308 ATP binding site [chemical binding]; other site 288705006309 Walker A motif; other site 288705006310 Walker B motif; other site 288705006311 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 288705006312 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 288705006313 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 288705006314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705006315 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 288705006316 CoA binding domain; Region: CoA_binding; smart00881 288705006317 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 288705006318 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 288705006319 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 288705006320 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 288705006321 CAP-like domain; other site 288705006322 active site 288705006323 primary dimer interface [polypeptide binding]; other site 288705006324 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288705006325 VanW like protein; Region: VanW; pfam04294 288705006326 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 288705006327 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288705006328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705006329 Coenzyme A binding pocket [chemical binding]; other site 288705006330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288705006331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705006332 Coenzyme A binding pocket [chemical binding]; other site 288705006333 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 288705006334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705006335 Walker A/P-loop; other site 288705006336 ATP binding site [chemical binding]; other site 288705006337 Q-loop/lid; other site 288705006338 ABC transporter signature motif; other site 288705006339 Walker B; other site 288705006340 D-loop; other site 288705006341 H-loop/switch region; other site 288705006342 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 288705006343 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 288705006344 Walker A/P-loop; other site 288705006345 ATP binding site [chemical binding]; other site 288705006346 Q-loop/lid; other site 288705006347 ABC transporter signature motif; other site 288705006348 Walker B; other site 288705006349 D-loop; other site 288705006350 H-loop/switch region; other site 288705006351 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 288705006352 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 288705006353 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 288705006354 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 288705006355 Penicillinase repressor; Region: Pencillinase_R; cl17580 288705006356 Peptidase family M48; Region: Peptidase_M48; cl12018 288705006357 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 288705006358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288705006359 ATP binding site [chemical binding]; other site 288705006360 Mg2+ binding site [ion binding]; other site 288705006361 G-X-G motif; other site 288705006362 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 288705006363 anchoring element; other site 288705006364 dimer interface [polypeptide binding]; other site 288705006365 ATP binding site [chemical binding]; other site 288705006366 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 288705006367 active site 288705006368 metal binding site [ion binding]; metal-binding site 288705006369 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 288705006370 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 288705006371 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 288705006372 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288705006373 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 288705006374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288705006375 DNA binding residues [nucleotide binding] 288705006376 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 288705006377 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 288705006378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705006379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288705006380 putative substrate translocation pore; other site 288705006381 PAC2 family; Region: PAC2; pfam09754 288705006382 multifunctional aminopeptidase A; Provisional; Region: PRK00913 288705006383 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 288705006384 interface (dimer of trimers) [polypeptide binding]; other site 288705006385 Substrate-binding/catalytic site; other site 288705006386 Zn-binding sites [ion binding]; other site 288705006387 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 288705006388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288705006389 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 288705006390 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 288705006391 Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226 288705006392 putative active site [active] 288705006393 Zn binding site [ion binding]; other site 288705006394 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 288705006395 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 288705006396 Uncharacterized conserved protein [Function unknown]; Region: COG2128 288705006397 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 288705006398 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 288705006399 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 288705006400 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 288705006401 protein binding site [polypeptide binding]; other site 288705006402 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 288705006403 Domain interface; other site 288705006404 Peptide binding site; other site 288705006405 Active site tetrad [active] 288705006406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705006407 TIGR01777 family protein; Region: yfcH 288705006408 NAD(P) binding site [chemical binding]; other site 288705006409 active site 288705006410 Protein kinase domain; Region: Pkinase; pfam00069 288705006411 Catalytic domain of Protein Kinases; Region: PKc; cd00180 288705006412 active site 288705006413 ATP binding site [chemical binding]; other site 288705006414 substrate binding site [chemical binding]; other site 288705006415 activation loop (A-loop); other site 288705006416 lipoate-protein ligase B; Provisional; Region: PRK14345 288705006417 lipoyl synthase; Provisional; Region: PRK05481 288705006418 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288705006419 FeS/SAM binding site; other site 288705006420 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 288705006421 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 288705006422 Malic enzyme, N-terminal domain; Region: malic; pfam00390 288705006423 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 288705006424 NAD(P) binding pocket [chemical binding]; other site 288705006425 RDD family; Region: RDD; pfam06271 288705006426 glutamine synthetase, type I; Region: GlnA; TIGR00653 288705006427 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 288705006428 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 288705006429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705006430 Transposase; Region: HTH_Tnp_1; cl17663 288705006431 putative transposase OrfB; Reviewed; Region: PHA02517 288705006432 HTH-like domain; Region: HTH_21; pfam13276 288705006433 Integrase core domain; Region: rve; pfam00665 288705006434 Integrase core domain; Region: rve_3; pfam13683 288705006435 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288705006436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288705006437 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288705006438 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 288705006439 Walker A/P-loop; other site 288705006440 ATP binding site [chemical binding]; other site 288705006441 Q-loop/lid; other site 288705006442 ABC transporter signature motif; other site 288705006443 Walker B; other site 288705006444 D-loop; other site 288705006445 H-loop/switch region; other site 288705006446 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 288705006447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288705006448 membrane-bound complex binding site; other site 288705006449 hinge residues; other site 288705006450 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 288705006451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705006452 dimer interface [polypeptide binding]; other site 288705006453 conserved gate region; other site 288705006454 putative PBP binding loops; other site 288705006455 ABC-ATPase subunit interface; other site 288705006456 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288705006457 YCII-related domain; Region: YCII; cl00999 288705006458 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 288705006459 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 288705006460 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 288705006461 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 288705006462 metal binding triad; other site 288705006463 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 288705006464 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 288705006465 metal binding triad; other site 288705006466 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 288705006467 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 288705006468 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 288705006469 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 288705006470 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 288705006471 oligomerization interface [polypeptide binding]; other site 288705006472 active site 288705006473 metal binding site [ion binding]; metal-binding site 288705006474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705006475 Transposase; Region: HTH_Tnp_1; cl17663 288705006476 putative transposase OrfB; Reviewed; Region: PHA02517 288705006477 HTH-like domain; Region: HTH_21; pfam13276 288705006478 Integrase core domain; Region: rve; pfam00665 288705006479 Integrase core domain; Region: rve_3; pfam13683 288705006480 AAA domain; Region: AAA_17; pfam13207 288705006481 AAA domain; Region: AAA_18; pfam13238 288705006482 Sporulation related domain; Region: SPOR; cl10051 288705006483 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 288705006484 active site 288705006485 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 288705006486 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288705006487 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288705006488 classical (c) SDRs; Region: SDR_c; cd05233 288705006489 NAD(P) binding site [chemical binding]; other site 288705006490 active site 288705006491 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 288705006492 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 288705006493 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 288705006494 ATP cone domain; Region: ATP-cone; pfam03477 288705006495 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 288705006496 histidinol dehydrogenase; Region: hisD; TIGR00069 288705006497 NAD binding site [chemical binding]; other site 288705006498 dimerization interface [polypeptide binding]; other site 288705006499 product binding site; other site 288705006500 substrate binding site [chemical binding]; other site 288705006501 zinc binding site [ion binding]; other site 288705006502 catalytic residues [active] 288705006503 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 288705006504 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 288705006505 active site 288705006506 PHP Thumb interface [polypeptide binding]; other site 288705006507 metal binding site [ion binding]; metal-binding site 288705006508 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 288705006509 generic binding surface II; other site 288705006510 generic binding surface I; other site 288705006511 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 288705006512 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 288705006513 active site 288705006514 lipoprotein signal peptidase; Provisional; Region: PRK14772 288705006515 DivIVA protein; Region: DivIVA; pfam05103 288705006516 DivIVA domain; Region: DivI1A_domain; TIGR03544 288705006517 Protein of unknown function (DUF552); Region: DUF552; pfam04472 288705006518 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 288705006519 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288705006520 catalytic residue [active] 288705006521 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 288705006522 cell division protein FtsZ; Validated; Region: PRK09330 288705006523 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 288705006524 nucleotide binding site [chemical binding]; other site 288705006525 SulA interaction site; other site 288705006526 cell division protein FtsQ; Provisional; Region: PRK05529 288705006527 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 288705006528 Cell division protein FtsQ; Region: FtsQ; pfam03799 288705006529 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 288705006530 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288705006531 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288705006532 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288705006533 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 288705006534 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 288705006535 active site 288705006536 homodimer interface [polypeptide binding]; other site 288705006537 cell division protein FtsW; Region: ftsW; TIGR02614 288705006538 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 288705006539 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288705006540 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288705006541 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 288705006542 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 288705006543 Mg++ binding site [ion binding]; other site 288705006544 putative catalytic motif [active] 288705006545 putative substrate binding site [chemical binding]; other site 288705006546 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 288705006547 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288705006548 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288705006549 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288705006550 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 288705006551 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288705006552 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288705006553 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288705006554 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 288705006555 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288705006556 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288705006557 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 288705006558 MraW methylase family; Region: Methyltransf_5; pfam01795 288705006559 cell division protein MraZ; Reviewed; Region: PRK00326 288705006560 MraZ protein; Region: MraZ; pfam02381 288705006561 MraZ protein; Region: MraZ; pfam02381 288705006562 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 288705006563 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 288705006564 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 288705006565 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 288705006566 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 288705006567 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 288705006568 active site 288705006569 DNA polymerase IV; Validated; Region: PRK02406 288705006570 DNA binding site [nucleotide binding] 288705006571 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 288705006572 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 288705006573 substrate binding pocket [chemical binding]; other site 288705006574 chain length determination region; other site 288705006575 substrate-Mg2+ binding site; other site 288705006576 catalytic residues [active] 288705006577 aspartate-rich region 1; other site 288705006578 active site lid residues [active] 288705006579 aspartate-rich region 2; other site 288705006580 Helix-turn-helix domain; Region: HTH_17; cl17695 288705006581 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288705006582 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288705006583 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288705006584 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 288705006585 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 288705006586 N-acetyl-D-glucosamine binding site [chemical binding]; other site 288705006587 catalytic residue [active] 288705006588 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 288705006589 Catalytic domain of Protein Kinases; Region: PKc; cd00180 288705006590 active site 288705006591 ATP binding site [chemical binding]; other site 288705006592 substrate binding site [chemical binding]; other site 288705006593 activation loop (A-loop); other site 288705006594 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 288705006595 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288705006596 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288705006597 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288705006598 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 288705006599 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 288705006600 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 288705006601 putative acyl-acceptor binding pocket; other site 288705006602 Esterase/lipase [General function prediction only]; Region: COG1647 288705006603 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 288705006604 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288705006605 nucleotide binding site [chemical binding]; other site 288705006606 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 288705006607 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 288705006608 acyl-activating enzyme (AAE) consensus motif; other site 288705006609 putative AMP binding site [chemical binding]; other site 288705006610 putative active site [active] 288705006611 putative CoA binding site [chemical binding]; other site 288705006612 pyruvate carboxylase; Reviewed; Region: PRK12999 288705006613 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288705006614 ATP-grasp domain; Region: ATP-grasp_4; cl17255 288705006615 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 288705006616 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 288705006617 active site 288705006618 catalytic residues [active] 288705006619 metal binding site [ion binding]; metal-binding site 288705006620 homodimer binding site [polypeptide binding]; other site 288705006621 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 288705006622 carboxyltransferase (CT) interaction site; other site 288705006623 biotinylation site [posttranslational modification]; other site 288705006624 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 288705006625 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288705006626 P-loop; other site 288705006627 Magnesium ion binding site [ion binding]; other site 288705006628 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288705006629 Magnesium ion binding site [ion binding]; other site 288705006630 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 288705006631 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 288705006632 DNA binding residues [nucleotide binding] 288705006633 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288705006634 putative dimer interface [polypeptide binding]; other site 288705006635 Bifunctional nuclease; Region: DNase-RNase; pfam02577 288705006636 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 288705006637 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288705006638 DNA binding residues [nucleotide binding] 288705006639 dimer interface [polypeptide binding]; other site 288705006640 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 288705006641 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 288705006642 phosphopeptide binding site; other site 288705006643 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 288705006644 lipoyl attachment site [posttranslational modification]; other site 288705006645 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 288705006646 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288705006647 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 288705006648 classical (c) SDRs; Region: SDR_c; cd05233 288705006649 NAD(P) binding site [chemical binding]; other site 288705006650 active site 288705006651 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 288705006652 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 288705006653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 288705006654 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 288705006655 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 288705006656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705006657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705006658 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 288705006659 phosphate binding site [ion binding]; other site 288705006660 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 288705006661 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 288705006662 phosphate binding site [ion binding]; other site 288705006663 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 288705006664 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 288705006665 active site 288705006666 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 288705006667 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 288705006668 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 288705006669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705006670 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 288705006671 putative NADP binding site [chemical binding]; other site 288705006672 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 288705006673 active site 288705006674 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 288705006675 active site 288705006676 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 288705006677 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 288705006678 active site 1 [active] 288705006679 active site 2 [active] 288705006680 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 288705006681 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288705006682 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288705006683 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288705006684 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 288705006685 catalytic site [active] 288705006686 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 288705006687 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 288705006688 homodimer interface [polypeptide binding]; other site 288705006689 active site 288705006690 TDP-binding site; other site 288705006691 acceptor substrate-binding pocket; other site 288705006692 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288705006693 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288705006694 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 288705006695 putative deacylase active site [active] 288705006696 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 288705006697 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 288705006698 heme binding pocket [chemical binding]; other site 288705006699 heme ligand [chemical binding]; other site 288705006700 FecCD transport family; Region: FecCD; pfam01032 288705006701 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 288705006702 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288705006703 Walker A/P-loop; other site 288705006704 ATP binding site [chemical binding]; other site 288705006705 Q-loop/lid; other site 288705006706 ABC transporter signature motif; other site 288705006707 Walker B; other site 288705006708 D-loop; other site 288705006709 H-loop/switch region; other site 288705006710 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 288705006711 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 288705006712 intersubunit interface [polypeptide binding]; other site 288705006713 Htaa; Region: HtaA; pfam04213 288705006714 Htaa; Region: HtaA; pfam04213 288705006715 Htaa; Region: HtaA; pfam04213 288705006716 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 288705006717 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288705006718 putative NAD(P) binding site [chemical binding]; other site 288705006719 Predicted transcriptional regulators [Transcription]; Region: COG1695 288705006720 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288705006721 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 288705006722 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 288705006723 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 288705006724 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 288705006725 active site 288705006726 FMN binding site [chemical binding]; other site 288705006727 2,4-decadienoyl-CoA binding site; other site 288705006728 catalytic residue [active] 288705006729 4Fe-4S cluster binding site [ion binding]; other site 288705006730 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288705006731 Flavin Reductases; Region: FlaRed; cl00801 288705006732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705006733 Transposase; Region: HTH_Tnp_1; cl17663 288705006734 putative transposase OrfB; Reviewed; Region: PHA02517 288705006735 HTH-like domain; Region: HTH_21; pfam13276 288705006736 Integrase core domain; Region: rve; pfam00665 288705006737 Integrase core domain; Region: rve_3; pfam13683 288705006738 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288705006739 amidase catalytic site [active] 288705006740 Zn binding residues [ion binding]; other site 288705006741 substrate binding site [chemical binding]; other site 288705006742 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288705006743 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 288705006744 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288705006745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705006746 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 288705006747 classical (c) SDRs; Region: SDR_c; cd05233 288705006748 NAD(P) binding site [chemical binding]; other site 288705006749 active site 288705006750 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288705006751 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288705006752 Predicted transcriptional regulators [Transcription]; Region: COG1695 288705006753 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288705006754 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 288705006755 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 288705006756 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 288705006757 substrate binding pocket [chemical binding]; other site 288705006758 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 288705006759 membrane-bound complex binding site; other site 288705006760 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 288705006761 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 288705006762 Walker A/P-loop; other site 288705006763 ATP binding site [chemical binding]; other site 288705006764 Q-loop/lid; other site 288705006765 ABC transporter signature motif; other site 288705006766 Walker B; other site 288705006767 D-loop; other site 288705006768 H-loop/switch region; other site 288705006769 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 288705006770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705006771 putative PBP binding loops; other site 288705006772 ABC-ATPase subunit interface; other site 288705006773 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 288705006774 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 288705006775 active site 288705006776 iron coordination sites [ion binding]; other site 288705006777 substrate binding pocket [chemical binding]; other site 288705006778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705006779 S-adenosylmethionine binding site [chemical binding]; other site 288705006780 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288705006781 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288705006782 sequence-specific DNA binding site [nucleotide binding]; other site 288705006783 salt bridge; other site 288705006784 Cupin domain; Region: Cupin_2; pfam07883 288705006785 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 288705006786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705006787 NAD(P) binding site [chemical binding]; other site 288705006788 active site 288705006789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288705006790 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288705006791 salt bridge; other site 288705006792 non-specific DNA binding site [nucleotide binding]; other site 288705006793 sequence-specific DNA binding site [nucleotide binding]; other site 288705006794 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 288705006795 polypeptide substrate binding site [polypeptide binding]; other site 288705006796 active site 288705006797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705006798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705006799 GTP-binding protein Der; Reviewed; Region: PRK03003 288705006800 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 288705006801 G1 box; other site 288705006802 GTP/Mg2+ binding site [chemical binding]; other site 288705006803 Switch I region; other site 288705006804 G2 box; other site 288705006805 Switch II region; other site 288705006806 G3 box; other site 288705006807 G4 box; other site 288705006808 G5 box; other site 288705006809 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 288705006810 G1 box; other site 288705006811 GTP/Mg2+ binding site [chemical binding]; other site 288705006812 Switch I region; other site 288705006813 G2 box; other site 288705006814 G3 box; other site 288705006815 Switch II region; other site 288705006816 G4 box; other site 288705006817 G5 box; other site 288705006818 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 288705006819 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 288705006820 putative acyl-acceptor binding pocket; other site 288705006821 cytidylate kinase; Provisional; Region: cmk; PRK00023 288705006822 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 288705006823 CMP-binding site; other site 288705006824 The sites determining sugar specificity; other site 288705006825 prephenate dehydrogenase; Validated; Region: PRK06545 288705006826 prephenate dehydrogenase; Validated; Region: PRK08507 288705006827 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 288705006828 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 288705006829 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288705006830 RNA binding surface [nucleotide binding]; other site 288705006831 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 288705006832 active site 288705006833 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 288705006834 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 288705006835 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 288705006836 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288705006837 P-loop; other site 288705006838 Magnesium ion binding site [ion binding]; other site 288705006839 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 288705006840 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288705006841 Magnesium ion binding site [ion binding]; other site 288705006842 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 288705006843 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 288705006844 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 288705006845 putative transposase OrfB; Reviewed; Region: PHA02517 288705006846 HTH-like domain; Region: HTH_21; pfam13276 288705006847 Integrase core domain; Region: rve; pfam00665 288705006848 Integrase core domain; Region: rve_3; pfam13683 288705006849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705006850 Transposase; Region: HTH_Tnp_1; cl17663 288705006851 EamA-like transporter family; Region: EamA; cl17759 288705006852 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 288705006853 Ligand Binding Site [chemical binding]; other site 288705006854 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 288705006855 Ligand Binding Site [chemical binding]; other site 288705006856 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 288705006857 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288705006858 inhibitor-cofactor binding pocket; inhibition site 288705006859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705006860 catalytic residue [active] 288705006861 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 288705006862 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 288705006863 tetrameric interface [polypeptide binding]; other site 288705006864 NAD binding site [chemical binding]; other site 288705006865 catalytic residues [active] 288705006866 substrate binding site [chemical binding]; other site 288705006867 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 288705006868 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 288705006869 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 288705006870 ferredoxin-NADP+ reductase; Region: PLN02852 288705006871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288705006872 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 288705006873 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 288705006874 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 288705006875 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 288705006876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705006877 dimer interface [polypeptide binding]; other site 288705006878 conserved gate region; other site 288705006879 ABC-ATPase subunit interface; other site 288705006880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705006881 Walker B; other site 288705006882 D-loop; other site 288705006883 H-loop/switch region; other site 288705006884 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 288705006885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705006886 Walker A/P-loop; other site 288705006887 ATP binding site [chemical binding]; other site 288705006888 Q-loop/lid; other site 288705006889 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 288705006890 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288705006891 substrate binding pocket [chemical binding]; other site 288705006892 membrane-bound complex binding site; other site 288705006893 hinge residues; other site 288705006894 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 288705006895 G4 box; other site 288705006896 G5 box; other site 288705006897 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 288705006898 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 288705006899 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 288705006900 G1 box; other site 288705006901 GTP/Mg2+ binding site [chemical binding]; other site 288705006902 G2 box; other site 288705006903 Switch I region; other site 288705006904 G3 box; other site 288705006905 Switch II region; other site 288705006906 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 288705006907 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 288705006908 Active Sites [active] 288705006909 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 288705006910 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 288705006911 Active Sites [active] 288705006912 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 288705006913 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 288705006914 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 288705006915 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 288705006916 putative transposase OrfB; Reviewed; Region: PHA02517 288705006917 HTH-like domain; Region: HTH_21; pfam13276 288705006918 Integrase core domain; Region: rve; pfam00665 288705006919 Integrase core domain; Region: rve_3; pfam13683 288705006920 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705006921 Transposase; Region: HTH_Tnp_1; cl17663 288705006922 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 288705006923 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 288705006924 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 288705006925 L-aspartate oxidase; Provisional; Region: PRK06175 288705006926 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 288705006927 L-aspartate oxidase; Provisional; Region: PRK06175 288705006928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288705006929 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288705006930 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288705006931 dimerization interface [polypeptide binding]; other site 288705006932 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 288705006933 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 288705006934 putative active site [active] 288705006935 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 288705006936 active site 288705006937 Predicted membrane protein [Function unknown]; Region: COG2860 288705006938 UPF0126 domain; Region: UPF0126; pfam03458 288705006939 UPF0126 domain; Region: UPF0126; pfam03458 288705006940 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 288705006941 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 288705006942 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 288705006943 substrate binding pocket [chemical binding]; other site 288705006944 chain length determination region; other site 288705006945 substrate-Mg2+ binding site; other site 288705006946 catalytic residues [active] 288705006947 aspartate-rich region 1; other site 288705006948 active site lid residues [active] 288705006949 aspartate-rich region 2; other site 288705006950 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 288705006951 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 288705006952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705006953 S-adenosylmethionine binding site [chemical binding]; other site 288705006954 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 288705006955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288705006956 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 288705006957 substrate binding pocket [chemical binding]; other site 288705006958 membrane-bound complex binding site; other site 288705006959 hinge residues; other site 288705006960 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 288705006961 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 288705006962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705006963 dimer interface [polypeptide binding]; other site 288705006964 conserved gate region; other site 288705006965 putative PBP binding loops; other site 288705006966 ABC-ATPase subunit interface; other site 288705006967 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288705006968 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 288705006969 Walker A/P-loop; other site 288705006970 ATP binding site [chemical binding]; other site 288705006971 Q-loop/lid; other site 288705006972 ABC transporter signature motif; other site 288705006973 Walker B; other site 288705006974 D-loop; other site 288705006975 H-loop/switch region; other site 288705006976 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 288705006977 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 288705006978 dimer interface [polypeptide binding]; other site 288705006979 tetramer interface [polypeptide binding]; other site 288705006980 PYR/PP interface [polypeptide binding]; other site 288705006981 TPP binding site [chemical binding]; other site 288705006982 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 288705006983 TPP-binding site; other site 288705006984 O-succinylbenzoate synthase; Provisional; Region: PRK02901 288705006985 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 288705006986 active site 288705006987 active site 288705006988 PAP2 superfamily; Region: PAP2; pfam01569 288705006989 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288705006990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705006991 putative substrate translocation pore; other site 288705006992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705006993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288705006994 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288705006995 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 288705006996 E3 interaction surface; other site 288705006997 lipoyl attachment site [posttranslational modification]; other site 288705006998 e3 binding domain; Region: E3_binding; pfam02817 288705006999 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 288705007000 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 288705007001 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 288705007002 alpha subunit interface [polypeptide binding]; other site 288705007003 TPP binding site [chemical binding]; other site 288705007004 heterodimer interface [polypeptide binding]; other site 288705007005 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288705007006 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 288705007007 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 288705007008 tetramer interface [polypeptide binding]; other site 288705007009 TPP-binding site [chemical binding]; other site 288705007010 heterodimer interface [polypeptide binding]; other site 288705007011 phosphorylation loop region [posttranslational modification] 288705007012 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 288705007013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705007014 putative DNA binding site [nucleotide binding]; other site 288705007015 putative Zn2+ binding site [ion binding]; other site 288705007016 AsnC family; Region: AsnC_trans_reg; pfam01037 288705007017 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288705007018 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288705007019 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 288705007020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288705007021 substrate binding site [chemical binding]; other site 288705007022 oxyanion hole (OAH) forming residues; other site 288705007023 trimer interface [polypeptide binding]; other site 288705007024 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 288705007025 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 288705007026 FAD binding pocket [chemical binding]; other site 288705007027 FAD binding motif [chemical binding]; other site 288705007028 phosphate binding motif [ion binding]; other site 288705007029 beta-alpha-beta structure motif; other site 288705007030 NAD(p) ribose binding residues [chemical binding]; other site 288705007031 NAD binding pocket [chemical binding]; other site 288705007032 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 288705007033 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 288705007034 catalytic loop [active] 288705007035 iron binding site [ion binding]; other site 288705007036 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 288705007037 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 288705007038 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 288705007039 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 288705007040 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 288705007041 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 288705007042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705007043 active site 288705007044 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 288705007045 Transcriptional regulator PadR-like family; Region: PadR; cl17335 288705007046 Predicted transcriptional regulators [Transcription]; Region: COG1695 288705007047 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 288705007048 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 288705007049 propionate/acetate kinase; Provisional; Region: PRK12379 288705007050 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 288705007051 Transcriptional regulator [Transcription]; Region: LytR; COG1316 288705007052 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462 288705007053 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 288705007054 CoenzymeA binding site [chemical binding]; other site 288705007055 subunit interaction site [polypeptide binding]; other site 288705007056 PHB binding site; other site 288705007057 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705007058 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 288705007059 acyl-activating enzyme (AAE) consensus motif; other site 288705007060 AMP binding site [chemical binding]; other site 288705007061 active site 288705007062 CoA binding site [chemical binding]; other site 288705007063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705007064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705007065 benzoate transport; Region: 2A0115; TIGR00895 288705007066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705007067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705007068 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 288705007069 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 288705007070 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 288705007071 active site 2 [active] 288705007072 active site 1 [active] 288705007073 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 288705007074 NAD(P) binding site [chemical binding]; other site 288705007075 catalytic residues [active] 288705007076 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 288705007077 Methyltransferase domain; Region: Methyltransf_11; pfam08241 288705007078 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 288705007079 CoenzymeA binding site [chemical binding]; other site 288705007080 subunit interaction site [polypeptide binding]; other site 288705007081 PHB binding site; other site 288705007082 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288705007083 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288705007084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288705007085 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 288705007086 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 288705007087 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 288705007088 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 288705007089 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288705007090 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 288705007091 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288705007092 substrate binding site [chemical binding]; other site 288705007093 oxyanion hole (OAH) forming residues; other site 288705007094 trimer interface [polypeptide binding]; other site 288705007095 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288705007096 Thiolase, N-terminal domain; Region: Thiolase_N; pfam00108 288705007097 dimer interface [polypeptide binding]; other site 288705007098 CAAX protease self-immunity; Region: Abi; pfam02517 288705007099 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288705007100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705007101 Walker A/P-loop; other site 288705007102 ATP binding site [chemical binding]; other site 288705007103 Q-loop/lid; other site 288705007104 ABC transporter signature motif; other site 288705007105 Walker B; other site 288705007106 D-loop; other site 288705007107 H-loop/switch region; other site 288705007108 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288705007109 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 288705007110 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 288705007111 Ligand Binding Site [chemical binding]; other site 288705007112 Molecular Tunnel; other site 288705007113 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288705007114 active site 288705007115 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288705007116 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 288705007117 substrate binding site [chemical binding]; other site 288705007118 oxyanion hole (OAH) forming residues; other site 288705007119 trimer interface [polypeptide binding]; other site 288705007120 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 288705007121 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705007122 acyl-activating enzyme (AAE) consensus motif; other site 288705007123 AMP binding site [chemical binding]; other site 288705007124 active site 288705007125 CoA binding site [chemical binding]; other site 288705007126 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 288705007127 UbiA prenyltransferase family; Region: UbiA; pfam01040 288705007128 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 288705007129 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 288705007130 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 288705007131 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 288705007132 ResB-like family; Region: ResB; pfam05140 288705007133 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 288705007134 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 288705007135 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 288705007136 catalytic residues [active] 288705007137 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288705007138 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 288705007139 catalytic core [active] 288705007140 YceI-like domain; Region: YceI; smart00867 288705007141 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 288705007142 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 288705007143 CoA binding domain; Region: CoA_binding; pfam02629 288705007144 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 288705007145 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 288705007146 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 288705007147 DNA binding domain, excisionase family; Region: excise; TIGR01764 288705007148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288705007149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288705007150 DNA binding residues [nucleotide binding] 288705007151 dimerization interface [polypeptide binding]; other site 288705007152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 288705007153 Transcriptional regulators [Transcription]; Region: FadR; COG2186 288705007154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288705007155 DNA-binding site [nucleotide binding]; DNA binding site 288705007156 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 288705007157 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 288705007158 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 288705007159 active site 288705007160 substrate binding site [chemical binding]; other site 288705007161 FMN binding site [chemical binding]; other site 288705007162 putative catalytic residues [active] 288705007163 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705007164 dimerization interface [polypeptide binding]; other site 288705007165 putative DNA binding site [nucleotide binding]; other site 288705007166 putative Zn2+ binding site [ion binding]; other site 288705007167 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 288705007168 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 288705007169 active site 288705007170 Zn binding site [ion binding]; other site 288705007171 Cation transport protein; Region: TrkH; cl17365 288705007172 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 288705007173 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 288705007174 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 288705007175 TrkA-N domain; Region: TrkA_N; pfam02254 288705007176 TrkA-C domain; Region: TrkA_C; pfam02080 288705007177 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 288705007178 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 288705007179 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 288705007180 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 288705007181 DNA interaction; other site 288705007182 exopolyphosphatase; Region: exo_poly_only; TIGR03706 288705007183 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 288705007184 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 288705007185 trimer interface [polypeptide binding]; other site 288705007186 active site 288705007187 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 288705007188 Domain of unknown function (DUF305); Region: DUF305; pfam03713 288705007189 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 288705007190 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 288705007191 active site 288705007192 interdomain interaction site; other site 288705007193 putative metal-binding site [ion binding]; other site 288705007194 nucleotide binding site [chemical binding]; other site 288705007195 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 288705007196 domain I; other site 288705007197 phosphate binding site [ion binding]; other site 288705007198 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 288705007199 domain II; other site 288705007200 domain III; other site 288705007201 nucleotide binding site [chemical binding]; other site 288705007202 DNA binding groove [nucleotide binding] 288705007203 catalytic site [active] 288705007204 domain IV; other site 288705007205 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 288705007206 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 288705007207 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288705007208 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288705007209 DNA binding residues [nucleotide binding] 288705007210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705007211 active site 288705007212 phosphorylation site [posttranslational modification] 288705007213 intermolecular recognition site; other site 288705007214 Putative sensor; Region: Sensor; pfam13796 288705007215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288705007216 Histidine kinase; Region: HisKA_3; pfam07730 288705007217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705007218 dimerization interface [polypeptide binding]; other site 288705007219 putative DNA binding site [nucleotide binding]; other site 288705007220 putative Zn2+ binding site [ion binding]; other site 288705007221 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 288705007222 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 288705007223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705007224 S-adenosylmethionine binding site [chemical binding]; other site 288705007225 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 288705007226 active site 288705007227 dimer interface [polypeptide binding]; other site 288705007228 motif 2; other site 288705007229 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 288705007230 motif 3; other site 288705007231 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 288705007232 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288705007233 hypothetical protein; Validated; Region: PRK01415 288705007234 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 288705007235 active site residue [active] 288705007236 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288705007237 cleavage site 288705007238 active site 288705007239 substrate binding sites [chemical binding]; other site 288705007240 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 288705007241 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288705007242 ATP binding site [chemical binding]; other site 288705007243 putative Mg++ binding site [ion binding]; other site 288705007244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705007245 nucleotide binding region [chemical binding]; other site 288705007246 ATP-binding site [chemical binding]; other site 288705007247 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 288705007248 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 288705007249 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 288705007250 Walker B motif; other site 288705007251 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 288705007252 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 288705007253 Walker A motif; other site 288705007254 ATP binding site [chemical binding]; other site 288705007255 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 288705007256 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 288705007257 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 288705007258 DNA binding site [nucleotide binding] 288705007259 active site 288705007260 catalytic site [active] 288705007261 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 288705007262 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 288705007263 putative active site [active] 288705007264 putative CoA binding site [chemical binding]; other site 288705007265 nudix motif; other site 288705007266 metal binding site [ion binding]; metal-binding site 288705007267 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 288705007268 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 288705007269 minor groove reading motif; other site 288705007270 helix-hairpin-helix signature motif; other site 288705007271 substrate binding pocket [chemical binding]; other site 288705007272 active site 288705007273 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 288705007274 putative transposase OrfB; Reviewed; Region: PHA02517 288705007275 HTH-like domain; Region: HTH_21; pfam13276 288705007276 Integrase core domain; Region: rve; pfam00665 288705007277 Integrase core domain; Region: rve_3; pfam13683 288705007278 Transposase; Region: HTH_Tnp_1; cl17663 288705007279 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705007280 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705007281 acyl-activating enzyme (AAE) consensus motif; other site 288705007282 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705007283 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705007284 active site 288705007285 CoA binding site [chemical binding]; other site 288705007286 AMP binding site [chemical binding]; other site 288705007287 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288705007288 active site 288705007289 metal binding site [ion binding]; metal-binding site 288705007290 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288705007291 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288705007292 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 288705007293 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 288705007294 Uncharacterized conserved protein [Function unknown]; Region: COG5476 288705007295 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 288705007296 MlrC C-terminus; Region: MlrC_C; pfam07171 288705007297 MlrC C-terminus; Region: MlrC_C; pfam07171 288705007298 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705007299 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 288705007300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705007301 dimer interface [polypeptide binding]; other site 288705007302 conserved gate region; other site 288705007303 putative PBP binding loops; other site 288705007304 ABC-ATPase subunit interface; other site 288705007305 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705007306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705007307 dimer interface [polypeptide binding]; other site 288705007308 conserved gate region; other site 288705007309 putative PBP binding loops; other site 288705007310 ABC-ATPase subunit interface; other site 288705007311 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288705007312 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288705007313 nucleotide binding site [chemical binding]; other site 288705007314 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288705007315 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288705007316 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705007317 putative DNA binding site [nucleotide binding]; other site 288705007318 putative Zn2+ binding site [ion binding]; other site 288705007319 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288705007320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 288705007321 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 288705007322 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 288705007323 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 288705007324 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705007325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705007326 putative PBP binding loops; other site 288705007327 ABC-ATPase subunit interface; other site 288705007328 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705007329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705007330 dimer interface [polypeptide binding]; other site 288705007331 conserved gate region; other site 288705007332 putative PBP binding loops; other site 288705007333 ABC-ATPase subunit interface; other site 288705007334 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288705007335 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 288705007336 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 288705007337 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 288705007338 Dehydroquinase class II; Region: DHquinase_II; pfam01220 288705007339 active site 288705007340 trimer interface [polypeptide binding]; other site 288705007341 dimer interface [polypeptide binding]; other site 288705007342 Colicin V production protein; Region: Colicin_V; pfam02674 288705007343 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 288705007344 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 288705007345 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 288705007346 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 288705007347 ligand binding site [chemical binding]; other site 288705007348 flexible hinge region; other site 288705007349 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 288705007350 putative switch regulator; other site 288705007351 non-specific DNA interactions [nucleotide binding]; other site 288705007352 DNA binding site [nucleotide binding] 288705007353 sequence specific DNA binding site [nucleotide binding]; other site 288705007354 putative cAMP binding site [chemical binding]; other site 288705007355 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 288705007356 nudix motif; other site 288705007357 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 288705007358 homotrimer interaction site [polypeptide binding]; other site 288705007359 putative active site [active] 288705007360 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 288705007361 Transglycosylase; Region: Transgly; pfam00912 288705007362 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 288705007363 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 288705007364 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 288705007365 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288705007366 putative active site [active] 288705007367 putative metal binding site [ion binding]; other site 288705007368 putative transposase OrfB; Reviewed; Region: PHA02517 288705007369 HTH-like domain; Region: HTH_21; pfam13276 288705007370 Integrase core domain; Region: rve; pfam00665 288705007371 Integrase core domain; Region: rve_3; pfam13683 288705007372 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705007373 Transposase; Region: HTH_Tnp_1; cl17663 288705007374 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 288705007375 RHS Repeat; Region: RHS_repeat; cl11982 288705007376 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 288705007377 RHS Repeat; Region: RHS_repeat; pfam05593 288705007378 RHS Repeat; Region: RHS_repeat; cl11982 288705007379 Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236 288705007380 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705007381 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705007382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705007383 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288705007384 Walker A/P-loop; other site 288705007385 ATP binding site [chemical binding]; other site 288705007386 Q-loop/lid; other site 288705007387 ABC transporter signature motif; other site 288705007388 Walker B; other site 288705007389 D-loop; other site 288705007390 H-loop/switch region; other site 288705007391 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705007392 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 288705007393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705007394 Walker A/P-loop; other site 288705007395 ATP binding site [chemical binding]; other site 288705007396 Q-loop/lid; other site 288705007397 ABC transporter signature motif; other site 288705007398 Walker B; other site 288705007399 D-loop; other site 288705007400 H-loop/switch region; other site 288705007401 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 288705007402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705007403 Transposase; Region: HTH_Tnp_1; cl17663 288705007404 putative transposase OrfB; Reviewed; Region: PHA02517 288705007405 HTH-like domain; Region: HTH_21; pfam13276 288705007406 Integrase core domain; Region: rve; pfam00665 288705007407 Integrase core domain; Region: rve_3; cl15866 288705007408 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 288705007409 NHL repeat; Region: NHL; pfam01436 288705007410 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 288705007411 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 288705007412 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 288705007413 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 288705007414 IHF - DNA interface [nucleotide binding]; other site 288705007415 IHF dimer interface [polypeptide binding]; other site 288705007416 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288705007417 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288705007418 active site 288705007419 catalytic tetrad [active] 288705007420 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 288705007421 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 288705007422 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 288705007423 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 288705007424 putative catalytic site [active] 288705007425 putative phosphate binding site [ion binding]; other site 288705007426 putative metal binding site [ion binding]; other site 288705007427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705007428 Transposase; Region: HTH_Tnp_1; cl17663 288705007429 putative transposase OrfB; Reviewed; Region: PHA02517 288705007430 HTH-like domain; Region: HTH_21; pfam13276 288705007431 Integrase core domain; Region: rve; pfam00665 288705007432 Integrase core domain; Region: rve_3; pfam13683 288705007433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705007434 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 288705007435 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 288705007436 hexamer interface [polypeptide binding]; other site 288705007437 ligand binding site [chemical binding]; other site 288705007438 putative active site [active] 288705007439 NAD(P) binding site [chemical binding]; other site 288705007440 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 288705007441 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 288705007442 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 288705007443 phosphate binding site [ion binding]; other site 288705007444 putative oxidoreductase; Provisional; Region: PRK11579 288705007445 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288705007446 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 288705007447 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288705007448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705007449 putative substrate translocation pore; other site 288705007450 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 288705007451 hypothetical protein; Provisional; Region: PRK07236 288705007452 hypothetical protein; Validated; Region: PRK05868 288705007453 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288705007454 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288705007455 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288705007456 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 288705007457 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 288705007458 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 288705007459 active site 288705007460 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705007461 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288705007462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705007463 homodimer interface [polypeptide binding]; other site 288705007464 catalytic residue [active] 288705007465 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 288705007466 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 288705007467 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 288705007468 NAD(P) binding site [chemical binding]; other site 288705007469 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 288705007470 active site 288705007471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705007472 active site 288705007473 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 288705007474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705007475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705007476 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 288705007477 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 288705007478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 288705007479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705007480 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 288705007481 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288705007482 ABC-ATPase subunit interface; other site 288705007483 dimer interface [polypeptide binding]; other site 288705007484 putative PBP binding regions; other site 288705007485 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 288705007486 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 288705007487 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 288705007488 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288705007489 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288705007490 Walker A/P-loop; other site 288705007491 ATP binding site [chemical binding]; other site 288705007492 Q-loop/lid; other site 288705007493 ABC transporter signature motif; other site 288705007494 Walker B; other site 288705007495 D-loop; other site 288705007496 H-loop/switch region; other site 288705007497 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 288705007498 FAD binding pocket [chemical binding]; other site 288705007499 FAD binding motif [chemical binding]; other site 288705007500 phosphate binding motif [ion binding]; other site 288705007501 NAD binding pocket [chemical binding]; other site 288705007502 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 288705007503 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 288705007504 intersubunit interface [polypeptide binding]; other site 288705007505 EVE domain; Region: EVE; cl00728 288705007506 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 288705007507 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 288705007508 catalytic Zn binding site [ion binding]; other site 288705007509 NAD(P) binding site [chemical binding]; other site 288705007510 structural Zn binding site [ion binding]; other site 288705007511 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 288705007512 active site 288705007513 catalytic triad [active] 288705007514 oxyanion hole [active] 288705007515 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 288705007516 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 288705007517 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 288705007518 Citrate transporter; Region: CitMHS; pfam03600 288705007519 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 288705007520 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 288705007521 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 288705007522 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 288705007523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705007524 Transposase; Region: HTH_Tnp_1; cl17663 288705007525 putative transposase OrfB; Reviewed; Region: PHA02517 288705007526 HTH-like domain; Region: HTH_21; pfam13276 288705007527 Integrase core domain; Region: rve; pfam00665 288705007528 Integrase core domain; Region: rve_3; pfam13683 288705007529 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 288705007530 putative transposase OrfB; Reviewed; Region: PHA02517 288705007531 HTH-like domain; Region: HTH_21; pfam13276 288705007532 Integrase core domain; Region: rve; pfam00665 288705007533 Integrase core domain; Region: rve_3; pfam13683 288705007534 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 288705007535 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 288705007536 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288705007537 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 288705007538 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 288705007539 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 288705007540 phosphopeptide binding site; other site 288705007541 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 288705007542 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 288705007543 phosphopeptide binding site; other site 288705007544 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 288705007545 active site 288705007546 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 288705007547 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 288705007548 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288705007549 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 288705007550 Catalytic domain of Protein Kinases; Region: PKc; cd00180 288705007551 active site 288705007552 ATP binding site [chemical binding]; other site 288705007553 substrate binding site [chemical binding]; other site 288705007554 activation loop (A-loop); other site 288705007555 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288705007556 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 288705007557 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288705007558 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 288705007559 active site 288705007560 ATP binding site [chemical binding]; other site 288705007561 substrate binding site [chemical binding]; other site 288705007562 activation loop (A-loop); other site 288705007563 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288705007564 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288705007565 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288705007566 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 288705007567 Glutamine amidotransferase class-I; Region: GATase; pfam00117 288705007568 glutamine binding [chemical binding]; other site 288705007569 catalytic triad [active] 288705007570 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 288705007571 active site 288705007572 catalytic site [active] 288705007573 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 288705007574 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 288705007575 Citrate synthase; Region: Citrate_synt; pfam00285 288705007576 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 288705007577 dimer interface [polypeptide binding]; other site 288705007578 active site 288705007579 oxalacetate/citrate binding site [chemical binding]; other site 288705007580 citrylCoA binding site [chemical binding]; other site 288705007581 coenzyme A binding site [chemical binding]; other site 288705007582 catalytic triad [active] 288705007583 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 288705007584 Citrate synthase; Region: Citrate_synt; pfam00285 288705007585 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 288705007586 Citrate synthase; Region: Citrate_synt; pfam00285 288705007587 oxalacetate binding site [chemical binding]; other site 288705007588 citrylCoA binding site [chemical binding]; other site 288705007589 coenzyme A binding site [chemical binding]; other site 288705007590 catalytic triad [active] 288705007591 Domain of unknown function (DUF756); Region: DUF756; pfam05506 288705007592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705007593 Transposase; Region: HTH_Tnp_1; cl17663 288705007594 putative transposase OrfB; Reviewed; Region: PHA02517 288705007595 HTH-like domain; Region: HTH_21; pfam13276 288705007596 Integrase core domain; Region: rve; pfam00665 288705007597 Integrase core domain; Region: rve_3; pfam13683 288705007598 DNA primase; Validated; Region: dnaG; PRK05667 288705007599 CHC2 zinc finger; Region: zf-CHC2; pfam01807 288705007600 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 288705007601 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 288705007602 active site 288705007603 metal binding site [ion binding]; metal-binding site 288705007604 interdomain interaction site; other site 288705007605 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 288705007606 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 288705007607 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288705007608 Zn2+ binding site [ion binding]; other site 288705007609 Mg2+ binding site [ion binding]; other site 288705007610 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 288705007611 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 288705007612 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 288705007613 FMN binding site [chemical binding]; other site 288705007614 active site 288705007615 catalytic residues [active] 288705007616 substrate binding site [chemical binding]; other site 288705007617 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 288705007618 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 288705007619 putative sugar binding sites [chemical binding]; other site 288705007620 Q-X-W motif; other site 288705007621 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 288705007622 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288705007623 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288705007624 dimerization interface [polypeptide binding]; other site 288705007625 DNA binding residues [nucleotide binding] 288705007626 Response regulator receiver domain; Region: Response_reg; pfam00072 288705007627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705007628 active site 288705007629 phosphorylation site [posttranslational modification] 288705007630 intermolecular recognition site; other site 288705007631 dimerization interface [polypeptide binding]; other site 288705007632 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288705007633 Histidine kinase; Region: HisKA_3; pfam07730 288705007634 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288705007635 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288705007636 Walker A/P-loop; other site 288705007637 ATP binding site [chemical binding]; other site 288705007638 Q-loop/lid; other site 288705007639 ABC transporter signature motif; other site 288705007640 Walker B; other site 288705007641 D-loop; other site 288705007642 H-loop/switch region; other site 288705007643 YibE/F-like protein; Region: YibE_F; pfam07907 288705007644 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 288705007645 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 288705007646 catalytic site [active] 288705007647 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 288705007648 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 288705007649 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 288705007650 putative acyl-acceptor binding pocket; other site 288705007651 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 288705007652 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 288705007653 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 288705007654 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 288705007655 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 288705007656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288705007657 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288705007658 dimerization interface [polypeptide binding]; other site 288705007659 Lysine efflux permease [General function prediction only]; Region: COG1279 288705007660 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 288705007661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705007662 Coenzyme A binding pocket [chemical binding]; other site 288705007663 glycyl-tRNA synthetase; Provisional; Region: PRK04173 288705007664 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 288705007665 motif 1; other site 288705007666 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 288705007667 dimer interface [polypeptide binding]; other site 288705007668 active site 288705007669 motif 2; other site 288705007670 motif 3; other site 288705007671 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 288705007672 anticodon binding site; other site 288705007673 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 288705007674 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 288705007675 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 288705007676 Ligand Binding Site [chemical binding]; other site 288705007677 Molecular Tunnel; other site 288705007678 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 288705007679 active site 288705007680 dimer interface [polypeptide binding]; other site 288705007681 Protein of unknown function, DUF606; Region: DUF606; pfam04657 288705007682 Protein of unknown function, DUF606; Region: DUF606; pfam04657 288705007683 Predicted esterase [General function prediction only]; Region: COG0400 288705007684 putative hydrolase; Provisional; Region: PRK11460 288705007685 Predicted ATPase [General function prediction only]; Region: COG4637 288705007686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705007687 Walker B; other site 288705007688 D-loop; other site 288705007689 H-loop/switch region; other site 288705007690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705007691 Walker A/P-loop; other site 288705007692 ATP binding site [chemical binding]; other site 288705007693 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 288705007694 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 288705007695 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 288705007696 active site 288705007697 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 288705007698 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 288705007699 nucleotide binding pocket [chemical binding]; other site 288705007700 K-X-D-G motif; other site 288705007701 catalytic site [active] 288705007702 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 288705007703 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 288705007704 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 288705007705 Dimer interface [polypeptide binding]; other site 288705007706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705007707 Transposase; Region: HTH_Tnp_1; cl17663 288705007708 putative transposase OrfB; Reviewed; Region: PHA02517 288705007709 HTH-like domain; Region: HTH_21; pfam13276 288705007710 Integrase core domain; Region: rve; pfam00665 288705007711 Integrase core domain; Region: rve_3; pfam13683 288705007712 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 288705007713 cyclase homology domain; Region: CHD; cd07302 288705007714 nucleotidyl binding site; other site 288705007715 metal binding site [ion binding]; metal-binding site 288705007716 dimer interface [polypeptide binding]; other site 288705007717 Bacterial PH domain; Region: DUF304; pfam03703 288705007718 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 288705007719 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 288705007720 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 288705007721 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 288705007722 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 288705007723 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 288705007724 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 288705007725 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 288705007726 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288705007727 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 288705007728 active site 288705007729 metal binding site [ion binding]; metal-binding site 288705007730 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 288705007731 Maf-like protein; Region: Maf; pfam02545 288705007732 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 288705007733 active site 288705007734 dimer interface [polypeptide binding]; other site 288705007735 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 288705007736 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288705007737 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 288705007738 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 288705007739 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 288705007740 carboxyltransferase (CT) interaction site; other site 288705007741 biotinylation site [posttranslational modification]; other site 288705007742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705007743 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288705007744 putative substrate translocation pore; other site 288705007745 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 288705007746 active site 288705007747 TDP-binding site; other site 288705007748 homodimer interface [polypeptide binding]; other site 288705007749 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288705007750 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288705007751 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 288705007752 substrate binding site [chemical binding]; other site 288705007753 oxyanion hole (OAH) forming residues; other site 288705007754 hypothetical protein; Provisional; Region: PRK06834 288705007755 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288705007756 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 288705007757 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288705007758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288705007759 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 288705007760 purine nucleoside phosphorylase; Provisional; Region: PRK08202 288705007761 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 288705007762 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 288705007763 active site 288705007764 substrate binding site [chemical binding]; other site 288705007765 metal binding site [ion binding]; metal-binding site 288705007766 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 288705007767 intersubunit interface [polypeptide binding]; other site 288705007768 active site 288705007769 catalytic residue [active] 288705007770 mycothione reductase; Reviewed; Region: PRK07846 288705007771 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 288705007772 metabolite-proton symporter; Region: 2A0106; TIGR00883 288705007773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705007774 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288705007775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288705007776 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288705007777 dimerization interface [polypeptide binding]; other site 288705007778 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 288705007779 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 288705007780 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 288705007781 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 288705007782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288705007783 ATP binding site [chemical binding]; other site 288705007784 putative Mg++ binding site [ion binding]; other site 288705007785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288705007786 nucleotide binding region [chemical binding]; other site 288705007787 ATP-binding site [chemical binding]; other site 288705007788 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 288705007789 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 288705007790 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 288705007791 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288705007792 Catalytic site [active] 288705007793 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 288705007794 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 288705007795 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288705007796 Catalytic site [active] 288705007797 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 288705007798 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 288705007799 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 288705007800 trimerization site [polypeptide binding]; other site 288705007801 active site 288705007802 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 288705007803 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 288705007804 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705007805 catalytic residue [active] 288705007806 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 288705007807 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 288705007808 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 288705007809 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 288705007810 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 288705007811 putative active site [active] 288705007812 catalytic residue [active] 288705007813 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 288705007814 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 288705007815 5S rRNA interface [nucleotide binding]; other site 288705007816 CTC domain interface [polypeptide binding]; other site 288705007817 L16 interface [polypeptide binding]; other site 288705007818 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 288705007819 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 288705007820 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288705007821 active site 288705007822 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 288705007823 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 288705007824 Substrate binding site; other site 288705007825 Mg++ binding site; other site 288705007826 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 288705007827 active site 288705007828 substrate binding site [chemical binding]; other site 288705007829 CoA binding site [chemical binding]; other site 288705007830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705007831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705007832 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288705007833 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288705007834 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288705007835 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 288705007836 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 288705007837 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 288705007838 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 288705007839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 288705007840 Domain of unknown function (DUF348); Region: DUF348; pfam03990 288705007841 G5 domain; Region: G5; pfam07501 288705007842 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 288705007843 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 288705007844 active site 288705007845 MoxR-like ATPases [General function prediction only]; Region: COG0714 288705007846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705007847 Walker A motif; other site 288705007848 ATP binding site [chemical binding]; other site 288705007849 Walker B motif; other site 288705007850 MoxR-like ATPases [General function prediction only]; Region: COG0714 288705007851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 288705007852 Protein of unknown function DUF58; Region: DUF58; pfam01882 288705007853 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 288705007854 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 288705007855 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 288705007856 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288705007857 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 288705007858 tetramerization interface [polypeptide binding]; other site 288705007859 NAD(P) binding site [chemical binding]; other site 288705007860 catalytic residues [active] 288705007861 Predicted methyltransferases [General function prediction only]; Region: COG0313 288705007862 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 288705007863 putative SAM binding site [chemical binding]; other site 288705007864 putative homodimer interface [polypeptide binding]; other site 288705007865 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 288705007866 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705007867 acyl-activating enzyme (AAE) consensus motif; other site 288705007868 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 288705007869 putative active site [active] 288705007870 putative CoA binding site [chemical binding]; other site 288705007871 putative AMP binding site [chemical binding]; other site 288705007872 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 288705007873 Integral membrane protein DUF95; Region: DUF95; pfam01944 288705007874 RDD family; Region: RDD; pfam06271 288705007875 Bacterial Ig-like domain; Region: Big_5; pfam13205 288705007876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 288705007877 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 288705007878 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 288705007879 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 288705007880 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 288705007881 homotetramer interface [polypeptide binding]; other site 288705007882 ligand binding site [chemical binding]; other site 288705007883 catalytic site [active] 288705007884 NAD binding site [chemical binding]; other site 288705007885 Trm112p-like protein; Region: Trm112p; cl01066 288705007886 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 288705007887 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 288705007888 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 288705007889 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288705007890 active site 288705007891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288705007892 Transcription factor WhiB; Region: Whib; pfam02467 288705007893 TIGR03089 family protein; Region: TIGR03089 288705007894 Predicted membrane protein [Function unknown]; Region: COG2246 288705007895 GtrA-like protein; Region: GtrA; pfam04138 288705007896 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 288705007897 ATP-grasp domain; Region: ATP-grasp; pfam02222 288705007898 AIR carboxylase; Region: AIRC; pfam00731 288705007899 Transcriptional regulator [Transcription]; Region: LytR; COG1316 288705007900 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 288705007901 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 288705007902 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 288705007903 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 288705007904 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 288705007905 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 288705007906 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 288705007907 putative active site [active] 288705007908 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 288705007909 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 288705007910 active site clefts [active] 288705007911 zinc binding site [ion binding]; other site 288705007912 dimer interface [polypeptide binding]; other site 288705007913 fumarate hydratase; Reviewed; Region: fumC; PRK00485 288705007914 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 288705007915 active sites [active] 288705007916 tetramer interface [polypeptide binding]; other site 288705007917 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 288705007918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705007919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705007920 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288705007921 putative substrate translocation pore; other site 288705007922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705007923 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 288705007924 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288705007925 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 288705007926 NAD(P) binding site [chemical binding]; other site 288705007927 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288705007928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288705007929 non-specific DNA binding site [nucleotide binding]; other site 288705007930 salt bridge; other site 288705007931 sequence-specific DNA binding site [nucleotide binding]; other site 288705007932 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 288705007933 nudix motif; other site 288705007934 Cupin domain; Region: Cupin_2; pfam07883 288705007935 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 288705007936 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 288705007937 putative active site [active] 288705007938 PhoH-like protein; Region: PhoH; pfam02562 288705007939 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 288705007940 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 288705007941 catalytic residue [active] 288705007942 putative FPP diphosphate binding site; other site 288705007943 putative FPP binding hydrophobic cleft; other site 288705007944 dimer interface [polypeptide binding]; other site 288705007945 putative IPP diphosphate binding site; other site 288705007946 Haemolysin-III related; Region: HlyIII; pfam03006 288705007947 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 288705007948 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 288705007949 catalytic residues [active] 288705007950 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 288705007951 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 288705007952 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 288705007953 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 288705007954 threonine dehydratase; Provisional; Region: PRK08198 288705007955 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 288705007956 tetramer interface [polypeptide binding]; other site 288705007957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705007958 catalytic residue [active] 288705007959 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 288705007960 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 288705007961 active site 288705007962 catalytic residues [active] 288705007963 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288705007964 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 288705007965 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 288705007966 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 288705007967 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 288705007968 nucleotide binding site/active site [active] 288705007969 HIT family signature motif; other site 288705007970 catalytic residue [active] 288705007971 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 288705007972 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 288705007973 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 288705007974 Bax inhibitor 1 like; Region: BaxI_1; cl17691 288705007975 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 288705007976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705007977 putative substrate translocation pore; other site 288705007978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705007979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705007980 NAD(P) binding site [chemical binding]; other site 288705007981 active site 288705007982 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288705007983 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 288705007984 DNA binding residues [nucleotide binding] 288705007985 putative transposase OrfB; Reviewed; Region: PHA02517 288705007986 HTH-like domain; Region: HTH_21; pfam13276 288705007987 Integrase core domain; Region: rve; pfam00665 288705007988 Integrase core domain; Region: rve_3; pfam13683 288705007989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705007990 dimer interface [polypeptide binding]; other site 288705007991 conserved gate region; other site 288705007992 putative PBP binding loops; other site 288705007993 ABC-ATPase subunit interface; other site 288705007994 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 288705007995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705007996 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 288705007997 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 288705007998 ADP-ribose binding site [chemical binding]; other site 288705007999 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288705008000 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288705008001 DNA binding site [nucleotide binding] 288705008002 domain linker motif; other site 288705008003 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288705008004 ligand binding site [chemical binding]; other site 288705008005 dimerization interface [polypeptide binding]; other site 288705008006 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 288705008007 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 288705008008 homodimer interface [polypeptide binding]; other site 288705008009 NAD binding pocket [chemical binding]; other site 288705008010 ATP binding pocket [chemical binding]; other site 288705008011 Mg binding site [ion binding]; other site 288705008012 active-site loop [active] 288705008013 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 288705008014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705008015 Walker A/P-loop; other site 288705008016 ATP binding site [chemical binding]; other site 288705008017 Q-loop/lid; other site 288705008018 ABC transporter signature motif; other site 288705008019 Walker B; other site 288705008020 D-loop; other site 288705008021 H-loop/switch region; other site 288705008022 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 288705008023 putative catalytic site [active] 288705008024 putative phosphate binding site [ion binding]; other site 288705008025 active site 288705008026 metal binding site A [ion binding]; metal-binding site 288705008027 DNA binding site [nucleotide binding] 288705008028 putative AP binding site [nucleotide binding]; other site 288705008029 putative metal binding site B [ion binding]; other site 288705008030 Predicted membrane protein [Function unknown]; Region: COG2259 288705008031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288705008032 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288705008033 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288705008034 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288705008035 DNA binding site [nucleotide binding] 288705008036 domain linker motif; other site 288705008037 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288705008038 dimerization interface [polypeptide binding]; other site 288705008039 ligand binding site [chemical binding]; other site 288705008040 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705008041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705008042 dimer interface [polypeptide binding]; other site 288705008043 conserved gate region; other site 288705008044 putative PBP binding loops; other site 288705008045 ABC-ATPase subunit interface; other site 288705008046 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 288705008047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705008048 dimer interface [polypeptide binding]; other site 288705008049 conserved gate region; other site 288705008050 putative PBP binding loops; other site 288705008051 ABC-ATPase subunit interface; other site 288705008052 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 288705008053 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705008054 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705008055 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 288705008056 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 288705008057 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 288705008058 active site 288705008059 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 288705008060 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 288705008061 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 288705008062 Asp23 family; Region: Asp23; pfam03780 288705008063 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 288705008064 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 288705008065 active site 288705008066 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 288705008067 active site 288705008068 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 288705008069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705008070 Coenzyme A binding pocket [chemical binding]; other site 288705008071 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 288705008072 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 288705008073 NlpC/P60 family; Region: NLPC_P60; pfam00877 288705008074 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 288705008075 Ligand Binding Site [chemical binding]; other site 288705008076 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 288705008077 Protein of unknown function (DUF664); Region: DUF664; pfam04978 288705008078 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 288705008079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705008080 NAD(P) binding site [chemical binding]; other site 288705008081 active site 288705008082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 288705008083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 288705008084 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 288705008085 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 288705008086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705008087 S-adenosylmethionine binding site [chemical binding]; other site 288705008088 Domain of unknown function DUF77; Region: DUF77; pfam01910 288705008089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705008090 putative transposase OrfB; Reviewed; Region: PHA02517 288705008091 HTH-like domain; Region: HTH_21; pfam13276 288705008092 Integrase core domain; Region: rve; pfam00665 288705008093 Integrase core domain; Region: rve_3; pfam13683 288705008094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705008095 Transposase; Region: HTH_Tnp_1; cl17663 288705008096 Predicted membrane protein [Function unknown]; Region: COG4270 288705008097 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 288705008098 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 288705008099 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288705008100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288705008101 DNA binding site [nucleotide binding] 288705008102 domain linker motif; other site 288705008103 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 288705008104 putative dimerization interface [polypeptide binding]; other site 288705008105 putative ligand binding site [chemical binding]; other site 288705008106 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 288705008107 L-idonate 5-dehydrogenase; Region: PLN02702 288705008108 inhibitor binding site; inhibition site 288705008109 catalytic Zn binding site [ion binding]; other site 288705008110 structural Zn binding site [ion binding]; other site 288705008111 NADP binding site [chemical binding]; other site 288705008112 tetramer interface [polypeptide binding]; other site 288705008113 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 288705008114 active site 288705008115 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 288705008116 catalytic site [active] 288705008117 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 288705008118 catalytic site [active] 288705008119 Protein of unknown function (DUF445); Region: DUF445; pfam04286 288705008120 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 288705008121 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 288705008122 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 288705008123 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 288705008124 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 288705008125 putative active site [active] 288705008126 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 288705008127 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 288705008128 Cation efflux family; Region: Cation_efflux; cl00316 288705008129 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 288705008130 Predicted transcriptional regulator [Transcription]; Region: COG2378 288705008131 HTH domain; Region: HTH_11; pfam08279 288705008132 WYL domain; Region: WYL; pfam13280 288705008133 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 288705008134 catalytic residue [active] 288705008135 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288705008136 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 288705008137 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 288705008138 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 288705008139 putative substrate binding site [chemical binding]; other site 288705008140 putative ATP binding site [chemical binding]; other site 288705008141 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 288705008142 active site 288705008143 phosphorylation site [posttranslational modification] 288705008144 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 288705008145 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 288705008146 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 288705008147 active site 288705008148 P-loop; other site 288705008149 phosphorylation site [posttranslational modification] 288705008150 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 288705008151 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 288705008152 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 288705008153 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 288705008154 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 288705008155 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 288705008156 dimerization domain swap beta strand [polypeptide binding]; other site 288705008157 regulatory protein interface [polypeptide binding]; other site 288705008158 active site 288705008159 regulatory phosphorylation site [posttranslational modification]; other site 288705008160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288705008161 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288705008162 proline/glycine betaine transporter; Provisional; Region: PRK10642 288705008163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705008164 proline/glycine betaine transporter; Provisional; Region: PRK10642 288705008165 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 288705008166 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 288705008167 short chain dehydrogenase; Provisional; Region: PRK06181 288705008168 classical (c) SDRs; Region: SDR_c; cd05233 288705008169 NAD(P) binding site [chemical binding]; other site 288705008170 active site 288705008171 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 288705008172 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 288705008173 DNA binding site [nucleotide binding] 288705008174 active site 288705008175 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 288705008176 Ferredoxin [Energy production and conversion]; Region: COG1146 288705008177 4Fe-4S binding domain; Region: Fer4; pfam00037 288705008178 ferredoxin-NADP+ reductase; Region: PLN02852 288705008179 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288705008180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705008181 putative DNA binding site [nucleotide binding]; other site 288705008182 putative Zn2+ binding site [ion binding]; other site 288705008183 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288705008184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705008185 putative substrate translocation pore; other site 288705008186 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288705008187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705008188 Walker A/P-loop; other site 288705008189 ATP binding site [chemical binding]; other site 288705008190 Q-loop/lid; other site 288705008191 ABC transporter signature motif; other site 288705008192 Walker B; other site 288705008193 D-loop; other site 288705008194 H-loop/switch region; other site 288705008195 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 288705008196 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 288705008197 TM-ABC transporter signature motif; other site 288705008198 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 288705008199 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 288705008200 putative ligand binding site [chemical binding]; other site 288705008201 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288705008202 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288705008203 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 288705008204 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 288705008205 peptidase domain interface [polypeptide binding]; other site 288705008206 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 288705008207 active site 288705008208 catalytic triad [active] 288705008209 calcium binding site [ion binding]; other site 288705008210 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 288705008211 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288705008212 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288705008213 catalytic residue [active] 288705008214 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288705008215 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288705008216 active site 288705008217 Zn binding site [ion binding]; other site 288705008218 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 288705008219 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 288705008220 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 288705008221 Walker A/P-loop; other site 288705008222 ATP binding site [chemical binding]; other site 288705008223 Q-loop/lid; other site 288705008224 ABC transporter signature motif; other site 288705008225 Walker B; other site 288705008226 D-loop; other site 288705008227 H-loop/switch region; other site 288705008228 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 288705008229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705008230 dimer interface [polypeptide binding]; other site 288705008231 conserved gate region; other site 288705008232 putative PBP binding loops; other site 288705008233 ABC-ATPase subunit interface; other site 288705008234 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 288705008235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705008236 dimer interface [polypeptide binding]; other site 288705008237 conserved gate region; other site 288705008238 putative PBP binding loops; other site 288705008239 ABC-ATPase subunit interface; other site 288705008240 PBP superfamily domain; Region: PBP_like_2; cl17296 288705008241 Predicted membrane protein [Function unknown]; Region: COG4129 288705008242 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 288705008243 DNA repair protein RadA; Provisional; Region: PRK11823 288705008244 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 288705008245 Walker A motif; other site 288705008246 ATP binding site [chemical binding]; other site 288705008247 Walker B motif; other site 288705008248 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 288705008249 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 288705008250 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 288705008251 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 288705008252 Helix-hairpin-helix motif; Region: HHH; pfam00633 288705008253 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 288705008254 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 288705008255 minor groove reading motif; other site 288705008256 helix-hairpin-helix signature motif; other site 288705008257 substrate binding pocket [chemical binding]; other site 288705008258 active site 288705008259 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 288705008260 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 288705008261 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 288705008262 regulatory phosphorylation site [posttranslational modification]; other site 288705008263 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 288705008264 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 288705008265 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 288705008266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705008267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705008268 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 288705008269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705008270 Coenzyme A binding pocket [chemical binding]; other site 288705008271 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 288705008272 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 288705008273 translocation protein TolB; Provisional; Region: tolB; PRK02889 288705008274 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 288705008275 Putative esterase; Region: Esterase; pfam00756 288705008276 Clp protease ATP binding subunit; Region: clpC; CHL00095 288705008277 Clp amino terminal domain; Region: Clp_N; pfam02861 288705008278 Clp amino terminal domain; Region: Clp_N; pfam02861 288705008279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705008280 Walker A motif; other site 288705008281 ATP binding site [chemical binding]; other site 288705008282 Walker B motif; other site 288705008283 arginine finger; other site 288705008284 UvrB/uvrC motif; Region: UVR; pfam02151 288705008285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705008286 Walker A motif; other site 288705008287 ATP binding site [chemical binding]; other site 288705008288 Walker B motif; other site 288705008289 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 288705008290 Lsr2; Region: Lsr2; pfam11774 288705008291 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 288705008292 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 288705008293 dimer interface [polypeptide binding]; other site 288705008294 putative anticodon binding site; other site 288705008295 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 288705008296 motif 1; other site 288705008297 dimer interface [polypeptide binding]; other site 288705008298 active site 288705008299 motif 2; other site 288705008300 motif 3; other site 288705008301 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288705008302 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288705008303 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288705008304 DNA binding site [nucleotide binding] 288705008305 domain linker motif; other site 288705008306 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288705008307 ligand binding site [chemical binding]; other site 288705008308 dimerization interface [polypeptide binding]; other site 288705008309 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 288705008310 active site 288705008311 tetramer interface [polypeptide binding]; other site 288705008312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705008313 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288705008314 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 288705008315 substrate binding site [chemical binding]; other site 288705008316 dimer interface [polypeptide binding]; other site 288705008317 ATP binding site [chemical binding]; other site 288705008318 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 288705008319 pantoate--beta-alanine ligase; Region: panC; TIGR00018 288705008320 active site 288705008321 nucleotide binding site [chemical binding]; other site 288705008322 HIGH motif; other site 288705008323 KMSKS motif; other site 288705008324 Rossmann-like domain; Region: Rossmann-like; pfam10727 288705008325 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 288705008326 Bacterial PH domain; Region: DUF304; pfam03703 288705008327 Bacterial PH domain; Region: DUF304; pfam03703 288705008328 Bacterial PH domain; Region: DUF304; pfam03703 288705008329 Uncharacterized conserved protein [Function unknown]; Region: COG3402 288705008330 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 288705008331 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 288705008332 catalytic center binding site [active] 288705008333 ATP binding site [chemical binding]; other site 288705008334 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 288705008335 homooctamer interface [polypeptide binding]; other site 288705008336 active site 288705008337 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 288705008338 dihydropteroate synthase; Region: DHPS; TIGR01496 288705008339 substrate binding pocket [chemical binding]; other site 288705008340 dimer interface [polypeptide binding]; other site 288705008341 inhibitor binding site; inhibition site 288705008342 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 288705008343 homodecamer interface [polypeptide binding]; other site 288705008344 GTP cyclohydrolase I; Provisional; Region: PLN03044 288705008345 active site 288705008346 putative catalytic site residues [active] 288705008347 zinc binding site [ion binding]; other site 288705008348 GTP-CH-I/GFRP interaction surface; other site 288705008349 FtsH Extracellular; Region: FtsH_ext; pfam06480 288705008350 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 288705008351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705008352 Walker A motif; other site 288705008353 ATP binding site [chemical binding]; other site 288705008354 Walker B motif; other site 288705008355 arginine finger; other site 288705008356 Peptidase family M41; Region: Peptidase_M41; pfam01434 288705008357 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 288705008358 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288705008359 active site 288705008360 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 288705008361 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 288705008362 Ligand Binding Site [chemical binding]; other site 288705008363 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 288705008364 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 288705008365 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 288705008366 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 288705008367 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 288705008368 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 288705008369 dimer interface [polypeptide binding]; other site 288705008370 substrate binding site [chemical binding]; other site 288705008371 metal binding sites [ion binding]; metal-binding site 288705008372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288705008373 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288705008374 active site 288705008375 motif I; other site 288705008376 motif II; other site 288705008377 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 288705008378 seryl-tRNA synthetase; Provisional; Region: PRK05431 288705008379 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 288705008380 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 288705008381 dimer interface [polypeptide binding]; other site 288705008382 active site 288705008383 motif 1; other site 288705008384 motif 2; other site 288705008385 motif 3; other site 288705008386 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 288705008387 prephenate dehydratase; Provisional; Region: PRK11898 288705008388 Prephenate dehydratase; Region: PDT; pfam00800 288705008389 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 288705008390 putative L-Phe binding site [chemical binding]; other site 288705008391 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288705008392 active site residue [active] 288705008393 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 288705008394 active site pocket [active] 288705008395 oxyanion hole [active] 288705008396 catalytic triad [active] 288705008397 active site nucleophile [active] 288705008398 putative transposase OrfB; Reviewed; Region: PHA02517 288705008399 HTH-like domain; Region: HTH_21; pfam13276 288705008400 Integrase core domain; Region: rve; pfam00665 288705008401 Integrase core domain; Region: rve_3; pfam13683 288705008402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705008403 Transposase; Region: HTH_Tnp_1; cl17663 288705008404 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705008405 acyl-activating enzyme (AAE) consensus motif; other site 288705008406 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 288705008407 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288705008408 substrate binding pocket [chemical binding]; other site 288705008409 membrane-bound complex binding site; other site 288705008410 hinge residues; other site 288705008411 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 288705008412 active site 288705008413 catalytic triad [active] 288705008414 oxyanion hole [active] 288705008415 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 288705008416 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 288705008417 hypothetical protein; Provisional; Region: PRK08244 288705008418 hypothetical protein; Provisional; Region: PRK07236 288705008419 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288705008420 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288705008421 catalytic core [active] 288705008422 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 288705008423 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 288705008424 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 288705008425 active site 288705008426 (T/H)XGH motif; other site 288705008427 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 288705008428 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 288705008429 putative catalytic cysteine [active] 288705008430 gamma-glutamyl kinase; Provisional; Region: PRK05429 288705008431 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 288705008432 homotetrameric interface [polypeptide binding]; other site 288705008433 putative phosphate binding site [ion binding]; other site 288705008434 putative allosteric binding site; other site 288705008435 nucleotide binding site [chemical binding]; other site 288705008436 PUA domain; Region: PUA; pfam01472 288705008437 GTPase CgtA; Reviewed; Region: obgE; PRK12296 288705008438 GTP1/OBG; Region: GTP1_OBG; pfam01018 288705008439 Obg GTPase; Region: Obg; cd01898 288705008440 G1 box; other site 288705008441 GTP/Mg2+ binding site [chemical binding]; other site 288705008442 Switch I region; other site 288705008443 G2 box; other site 288705008444 G3 box; other site 288705008445 Switch II region; other site 288705008446 G4 box; other site 288705008447 G5 box; other site 288705008448 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 288705008449 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 288705008450 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 288705008451 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 288705008452 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 288705008453 dimer interface [polypeptide binding]; other site 288705008454 substrate binding site [chemical binding]; other site 288705008455 ATP binding site [chemical binding]; other site 288705008456 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 288705008457 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 288705008458 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 288705008459 homodimer interface [polypeptide binding]; other site 288705008460 oligonucleotide binding site [chemical binding]; other site 288705008461 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 288705008462 putative active site [active] 288705008463 redox center [active] 288705008464 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 288705008465 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 288705008466 active site 288705008467 HIGH motif; other site 288705008468 dimer interface [polypeptide binding]; other site 288705008469 KMSKS motif; other site 288705008470 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 288705008471 active site 288705008472 multimer interface [polypeptide binding]; other site 288705008473 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 288705008474 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 288705008475 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288705008476 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288705008477 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 288705008478 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 288705008479 HIGH motif; other site 288705008480 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 288705008481 active site 288705008482 KMSKS motif; other site 288705008483 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 288705008484 tRNA binding surface [nucleotide binding]; other site 288705008485 anticodon binding site; other site 288705008486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705008487 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 288705008488 NAD(P) binding site [chemical binding]; other site 288705008489 active site 288705008490 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 288705008491 putative NAD(P) binding site [chemical binding]; other site 288705008492 homodimer interface [polypeptide binding]; other site 288705008493 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 288705008494 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 288705008495 active site 288705008496 HIGH motif; other site 288705008497 nucleotide binding site [chemical binding]; other site 288705008498 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 288705008499 active site 288705008500 KMSKS motif; other site 288705008501 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 288705008502 tRNA binding surface [nucleotide binding]; other site 288705008503 anticodon binding site; other site 288705008504 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 288705008505 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 288705008506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705008507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705008508 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 288705008509 classical (c) SDRs; Region: SDR_c; cd05233 288705008510 NAD(P) binding site [chemical binding]; other site 288705008511 active site 288705008512 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 288705008513 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 288705008514 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 288705008515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705008516 Walker A motif; other site 288705008517 ATP binding site [chemical binding]; other site 288705008518 Walker B motif; other site 288705008519 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 288705008520 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 288705008521 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 288705008522 oligomer interface [polypeptide binding]; other site 288705008523 active site residues [active] 288705008524 Clp protease; Region: CLP_protease; pfam00574 288705008525 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 288705008526 oligomer interface [polypeptide binding]; other site 288705008527 active site residues [active] 288705008528 trigger factor; Provisional; Region: tig; PRK01490 288705008529 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 288705008530 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 288705008531 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 288705008532 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 288705008533 putative DNA binding site [nucleotide binding]; other site 288705008534 catalytic residue [active] 288705008535 putative H2TH interface [polypeptide binding]; other site 288705008536 putative catalytic residues [active] 288705008537 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 288705008538 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 288705008539 Cna protein B-type domain; Region: Cna_B; pfam05738 288705008540 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 288705008541 Predicted dinucleotide-utilizing enzyme [General function prediction only]; Region: COG1712 288705008542 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 288705008543 Domain of unknown function DUF108; Region: DUF108; pfam01958 288705008544 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 288705008545 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 288705008546 Zn binding site [ion binding]; other site 288705008547 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 288705008548 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 288705008549 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288705008550 ATP-grasp domain; Region: ATP-grasp_4; cl17255 288705008551 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 288705008552 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 288705008553 active site 288705008554 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 288705008555 Cytochrome P450; Region: p450; cl12078 288705008556 Cytochrome P450; Region: p450; cl12078 288705008557 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288705008558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705008559 OsmC-like protein; Region: OsmC; cl00767 288705008560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705008561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705008562 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288705008563 NAD(P) binding site [chemical binding]; other site 288705008564 active site 288705008565 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 288705008566 Mechanosensitive ion channel; Region: MS_channel; pfam00924 288705008567 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 288705008568 apolar tunnel; other site 288705008569 heme binding site [chemical binding]; other site 288705008570 dimerization interface [polypeptide binding]; other site 288705008571 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 288705008572 active site 288705008573 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 288705008574 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 288705008575 active site 288705008576 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 288705008577 catalytic triad [active] 288705008578 dimer interface [polypeptide binding]; other site 288705008579 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 288705008580 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288705008581 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288705008582 ABC transporter; Region: ABC_tran_2; pfam12848 288705008583 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288705008584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705008585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288705008586 putative substrate translocation pore; other site 288705008587 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 288705008588 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 288705008589 dimer interface [polypeptide binding]; other site 288705008590 ssDNA binding site [nucleotide binding]; other site 288705008591 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288705008592 MepB protein; Region: MepB; cl01985 288705008593 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 288705008594 active site 288705008595 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 288705008596 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 288705008597 active site 288705008598 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 288705008599 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 288705008600 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 288705008601 catalytic site [active] 288705008602 putative active site [active] 288705008603 putative substrate binding site [chemical binding]; other site 288705008604 dimer interface [polypeptide binding]; other site 288705008605 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 288705008606 active site 288705008607 catalytic residues [active] 288705008608 metal binding site [ion binding]; metal-binding site 288705008609 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 288705008610 GAF domain; Region: GAF_2; pfam13185 288705008611 GAF domain; Region: GAF; cl17456 288705008612 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 288705008613 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 288705008614 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 288705008615 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 288705008616 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 288705008617 FMN binding site [chemical binding]; other site 288705008618 active site 288705008619 substrate binding site [chemical binding]; other site 288705008620 catalytic residue [active] 288705008621 hypothetical protein; Validated; Region: PRK02101 288705008622 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 288705008623 Putative zinc ribbon domain; Region: DUF164; pfam02591 288705008624 Uncharacterized conserved protein [Function unknown]; Region: COG0327 288705008625 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 288705008626 methionine sulfoxide reductase A; Provisional; Region: PRK14054 288705008627 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 288705008628 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 288705008629 dimer interface [polypeptide binding]; other site 288705008630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288705008631 catalytic residue [active] 288705008632 serine O-acetyltransferase; Region: cysE; TIGR01172 288705008633 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 288705008634 trimer interface [polypeptide binding]; other site 288705008635 active site 288705008636 substrate binding site [chemical binding]; other site 288705008637 CoA binding site [chemical binding]; other site 288705008638 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 288705008639 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 288705008640 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 288705008641 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 288705008642 Transposase; Region: HTH_Tnp_1; cl17663 288705008643 putative transposase OrfB; Reviewed; Region: PHA02517 288705008644 HTH-like domain; Region: HTH_21; pfam13276 288705008645 Integrase core domain; Region: rve; pfam00665 288705008646 Integrase core domain; Region: rve_3; pfam13683 288705008647 putative transposase OrfB; Reviewed; Region: PHA02517 288705008648 HTH-like domain; Region: HTH_21; pfam13276 288705008649 Integrase core domain; Region: rve; pfam00665 288705008650 Integrase core domain; Region: rve_3; pfam13683 288705008651 Transposase; Region: HTH_Tnp_1; cl17663 288705008652 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 288705008653 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705008654 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705008655 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705008656 active site 288705008657 AMP binding site [chemical binding]; other site 288705008658 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 288705008659 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 288705008660 Condensation domain; Region: Condensation; pfam00668 288705008661 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 288705008662 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 288705008663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705008664 Coenzyme A binding pocket [chemical binding]; other site 288705008665 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 288705008666 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 288705008667 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 288705008668 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 288705008669 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 288705008670 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288705008671 ABC-ATPase subunit interface; other site 288705008672 dimer interface [polypeptide binding]; other site 288705008673 putative PBP binding regions; other site 288705008674 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 288705008675 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 288705008676 intersubunit interface [polypeptide binding]; other site 288705008677 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 288705008678 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 288705008679 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 288705008680 active site 288705008681 HIGH motif; other site 288705008682 nucleotide binding site [chemical binding]; other site 288705008683 active site 288705008684 KMSKS motif; other site 288705008685 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 288705008686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705008687 Walker A motif; other site 288705008688 ATP binding site [chemical binding]; other site 288705008689 Walker B motif; other site 288705008690 arginine finger; other site 288705008691 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 288705008692 recombination protein RecR; Reviewed; Region: recR; PRK00076 288705008693 RecR protein; Region: RecR; pfam02132 288705008694 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 288705008695 putative active site [active] 288705008696 putative metal-binding site [ion binding]; other site 288705008697 tetramer interface [polypeptide binding]; other site 288705008698 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 288705008699 dimer interface [polypeptide binding]; other site 288705008700 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288705008701 aspartate kinase; Reviewed; Region: PRK06635 288705008702 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 288705008703 putative nucleotide binding site [chemical binding]; other site 288705008704 putative catalytic residues [active] 288705008705 putative Mg ion binding site [ion binding]; other site 288705008706 putative aspartate binding site [chemical binding]; other site 288705008707 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 288705008708 putative allosteric regulatory site; other site 288705008709 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 288705008710 putative allosteric regulatory residue; other site 288705008711 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 288705008712 Domain of unknown function (DUF718); Region: DUF718; cl01281 288705008713 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 288705008714 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 288705008715 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 288705008716 Amidohydrolase; Region: Amidohydro_2; pfam04909 288705008717 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 288705008718 active site 288705008719 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 288705008720 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 288705008721 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 288705008722 putative active site [active] 288705008723 catalytic triad [active] 288705008724 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 288705008725 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 288705008726 dimerization interface [polypeptide binding]; other site 288705008727 ATP binding site [chemical binding]; other site 288705008728 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 288705008729 dimerization interface [polypeptide binding]; other site 288705008730 ATP binding site [chemical binding]; other site 288705008731 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 288705008732 active site 288705008733 Mn binding site [ion binding]; other site 288705008734 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 288705008735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 288705008736 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 288705008737 NodB motif; other site 288705008738 active site 288705008739 catalytic site [active] 288705008740 metal binding site [ion binding]; metal-binding site 288705008741 CoA binding domain; Region: CoA_binding; cl17356 288705008742 putative transposase OrfB; Reviewed; Region: PHA02517 288705008743 HTH-like domain; Region: HTH_21; pfam13276 288705008744 Integrase core domain; Region: rve; pfam00665 288705008745 Integrase core domain; Region: rve_3; pfam13683 288705008746 Transposase; Region: HTH_Tnp_1; cl17663 288705008747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705008748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705008749 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288705008750 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288705008751 active site 288705008752 Predicted amidohydrolase [General function prediction only]; Region: COG0388 288705008753 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 288705008754 putative active site [active] 288705008755 catalytic triad [active] 288705008756 putative dimer interface [polypeptide binding]; other site 288705008757 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 288705008758 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 288705008759 GDP-binding site [chemical binding]; other site 288705008760 ACT binding site; other site 288705008761 IMP binding site; other site 288705008762 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 288705008763 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 288705008764 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 288705008765 active site 288705008766 intersubunit interface [polypeptide binding]; other site 288705008767 zinc binding site [ion binding]; other site 288705008768 Na+ binding site [ion binding]; other site 288705008769 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 288705008770 catalytic residues [active] 288705008771 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 288705008772 active site 288705008773 catalytic residues [active] 288705008774 putative transposase OrfB; Reviewed; Region: PHA02517 288705008775 HTH-like domain; Region: HTH_21; pfam13276 288705008776 Integrase core domain; Region: rve; pfam00665 288705008777 Integrase core domain; Region: rve_3; pfam13683 288705008778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705008779 Transposase; Region: HTH_Tnp_1; cl17663 288705008780 Histidine kinase; Region: HisKA_3; pfam07730 288705008781 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 288705008782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288705008783 UMP phosphatase; Provisional; Region: PRK10444 288705008784 active site 288705008785 motif I; other site 288705008786 motif II; other site 288705008787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288705008788 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 288705008789 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 288705008790 active site 288705008791 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 288705008792 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 288705008793 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288705008794 active site 288705008795 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 288705008796 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 288705008797 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 288705008798 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 288705008799 active site 288705008800 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 288705008801 catalytic site [active] 288705008802 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288705008803 putative DNA binding site [nucleotide binding]; other site 288705008804 putative Zn2+ binding site [ion binding]; other site 288705008805 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288705008806 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 288705008807 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288705008808 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 288705008809 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 288705008810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705008811 ABC-ATPase subunit interface; other site 288705008812 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288705008813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705008814 dimer interface [polypeptide binding]; other site 288705008815 conserved gate region; other site 288705008816 putative PBP binding loops; other site 288705008817 ABC-ATPase subunit interface; other site 288705008818 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 288705008819 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 288705008820 NAD binding site [chemical binding]; other site 288705008821 sugar binding site [chemical binding]; other site 288705008822 divalent metal binding site [ion binding]; other site 288705008823 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288705008824 dimer interface [polypeptide binding]; other site 288705008825 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 288705008826 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 288705008827 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 288705008828 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 288705008829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705008830 NAD(P) binding site [chemical binding]; other site 288705008831 active site 288705008832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705008833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705008834 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 288705008835 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 288705008836 metal binding site [ion binding]; metal-binding site 288705008837 substrate binding pocket [chemical binding]; other site 288705008838 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 288705008839 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 288705008840 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 288705008841 Glucuronate isomerase; Region: UxaC; cl00829 288705008842 Glucuronate isomerase; Region: UxaC; cl00829 288705008843 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 288705008844 putative transposase OrfB; Reviewed; Region: PHA02517 288705008845 HTH-like domain; Region: HTH_21; pfam13276 288705008846 Integrase core domain; Region: rve; pfam00665 288705008847 Integrase core domain; Region: rve_3; pfam13683 288705008848 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 288705008849 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 288705008850 putative active site [active] 288705008851 putative ligand binding site [chemical binding]; other site 288705008852 putative NAD(P) binding site [chemical binding]; other site 288705008853 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 288705008854 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288705008855 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 288705008856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705008857 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288705008858 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288705008859 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288705008860 Walker A/P-loop; other site 288705008861 ATP binding site [chemical binding]; other site 288705008862 Q-loop/lid; other site 288705008863 ABC transporter signature motif; other site 288705008864 Walker B; other site 288705008865 D-loop; other site 288705008866 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 288705008867 nucleophilic elbow; other site 288705008868 catalytic triad; other site 288705008869 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288705008870 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 288705008871 substrate binding pocket [chemical binding]; other site 288705008872 membrane-bound complex binding site; other site 288705008873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705008874 Transposase; Region: HTH_Tnp_1; cl17663 288705008875 putative transposase OrfB; Reviewed; Region: PHA02517 288705008876 HTH-like domain; Region: HTH_21; pfam13276 288705008877 Integrase core domain; Region: rve; pfam00665 288705008878 Integrase core domain; Region: rve_3; pfam13683 288705008879 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705008880 CoA binding site [chemical binding]; other site 288705008881 short chain dehydrogenase; Provisional; Region: PRK08278 288705008882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705008883 NAD(P) binding site [chemical binding]; other site 288705008884 active site 288705008885 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 288705008886 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 288705008887 Ligand Binding Site [chemical binding]; other site 288705008888 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 288705008889 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 288705008890 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 288705008891 Ligand binding site [chemical binding]; other site 288705008892 Electron transfer flavoprotein domain; Region: ETF; pfam01012 288705008893 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 288705008894 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288705008895 substrate binding site [chemical binding]; other site 288705008896 oxyanion hole (OAH) forming residues; other site 288705008897 trimer interface [polypeptide binding]; other site 288705008898 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 288705008899 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288705008900 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 288705008901 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288705008902 dimer interface [polypeptide binding]; other site 288705008903 active site 288705008904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288705008905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705008906 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288705008907 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288705008908 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 288705008909 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 288705008910 NAD binding site [chemical binding]; other site 288705008911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 288705008912 HTH-like domain; Region: HTH_21; pfam13276 288705008913 Integrase core domain; Region: rve; pfam00665 288705008914 Integrase core domain; Region: rve_3; pfam13683 288705008915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705008916 Transposase; Region: HTH_Tnp_1; cl17663 288705008917 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288705008918 dimerization interface [polypeptide binding]; other site 288705008919 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 288705008920 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 288705008921 NAD(P) binding site [chemical binding]; other site 288705008922 catalytic residues [active] 288705008923 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 288705008924 methionine synthase; Provisional; Region: PRK01207 288705008925 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 288705008926 substrate binding site [chemical binding]; other site 288705008927 THF binding site; other site 288705008928 zinc-binding site [ion binding]; other site 288705008929 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 288705008930 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 288705008931 FAD binding site [chemical binding]; other site 288705008932 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 288705008933 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 288705008934 metal ion-dependent adhesion site (MIDAS); other site 288705008935 von Willebrand factor type A domain; Region: VWA_2; pfam13519 288705008936 metal ion-dependent adhesion site (MIDAS); other site 288705008937 Protein of unknown function DUF58; Region: DUF58; pfam01882 288705008938 MoxR-like ATPases [General function prediction only]; Region: COG0714 288705008939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288705008940 Walker A motif; other site 288705008941 ATP binding site [chemical binding]; other site 288705008942 Walker B motif; other site 288705008943 arginine finger; other site 288705008944 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288705008945 acyl-activating enzyme (AAE) consensus motif; other site 288705008946 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 288705008947 putative active site [active] 288705008948 putative CoA binding site [chemical binding]; other site 288705008949 putative AMP binding site [chemical binding]; other site 288705008950 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 288705008951 non-specific DNA interactions [nucleotide binding]; other site 288705008952 DNA binding site [nucleotide binding] 288705008953 sequence specific DNA binding site [nucleotide binding]; other site 288705008954 putative cAMP binding site [chemical binding]; other site 288705008955 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288705008956 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288705008957 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288705008958 Phosphotransferase enzyme family; Region: APH; pfam01636 288705008959 active site 288705008960 substrate binding site [chemical binding]; other site 288705008961 ATP binding site [chemical binding]; other site 288705008962 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 288705008963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705008964 S-adenosylmethionine binding site [chemical binding]; other site 288705008965 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288705008966 Histidine kinase; Region: HisKA_3; pfam07730 288705008967 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288705008968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288705008969 active site 288705008970 phosphorylation site [posttranslational modification] 288705008971 intermolecular recognition site; other site 288705008972 dimerization interface [polypeptide binding]; other site 288705008973 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288705008974 DNA binding residues [nucleotide binding] 288705008975 dimerization interface [polypeptide binding]; other site 288705008976 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288705008977 active site 288705008978 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288705008979 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 288705008980 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 288705008981 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288705008982 DNA binding residues [nucleotide binding] 288705008983 drug binding residues [chemical binding]; other site 288705008984 dimer interface [polypeptide binding]; other site 288705008985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705008986 Transposase; Region: HTH_Tnp_1; cl17663 288705008987 putative transposase OrfB; Reviewed; Region: PHA02517 288705008988 HTH-like domain; Region: HTH_21; pfam13276 288705008989 Integrase core domain; Region: rve; pfam00665 288705008990 Integrase core domain; Region: rve_3; pfam13683 288705008991 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 288705008992 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 288705008993 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288705008994 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 288705008995 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 288705008996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705008997 S-adenosylmethionine binding site [chemical binding]; other site 288705008998 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 288705008999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288705009000 S-adenosylmethionine binding site [chemical binding]; other site 288705009001 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 288705009002 catalytic residues [active] 288705009003 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 288705009004 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 288705009005 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 288705009006 Class I ribonucleotide reductase; Region: RNR_I; cd01679 288705009007 active site 288705009008 dimer interface [polypeptide binding]; other site 288705009009 catalytic residues [active] 288705009010 effector binding site; other site 288705009011 R2 peptide binding site; other site 288705009012 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 288705009013 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 288705009014 dimer interface [polypeptide binding]; other site 288705009015 putative radical transfer pathway; other site 288705009016 diiron center [ion binding]; other site 288705009017 tyrosyl radical; other site 288705009018 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 288705009019 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 288705009020 Domain of unknown function (DUF427); Region: DUF427; cl00998 288705009021 Domain of unknown function (DUF427); Region: DUF427; cl00998 288705009022 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 288705009023 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 288705009024 catalytic residues [active] 288705009025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288705009026 Coenzyme A binding pocket [chemical binding]; other site 288705009027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 288705009028 HTH-like domain; Region: HTH_21; pfam13276 288705009029 Integrase core domain; Region: rve; pfam00665 288705009030 Integrase core domain; Region: rve_3; pfam13683 288705009031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288705009032 Transposase; Region: HTH_Tnp_1; cl17663 288705009033 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 288705009034 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 288705009035 Spore germination protein; Region: Spore_permease; cl17796 288705009036 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 288705009037 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 288705009038 intersubunit interface [polypeptide binding]; other site 288705009039 NlpC/P60 family; Region: NLPC_P60; cl17555 288705009040 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 288705009041 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 288705009042 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 288705009043 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 288705009044 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 288705009045 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 288705009046 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 288705009047 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 288705009048 Ligand Binding Site [chemical binding]; other site 288705009049 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 288705009050 Ligand Binding Site [chemical binding]; other site 288705009051 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288705009052 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 288705009053 tetracycline repressor protein TetR; Provisional; Region: PRK13756 288705009054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288705009055 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 288705009056 putative transposase OrfB; Reviewed; Region: PHA02517 288705009057 HTH-like domain; Region: HTH_21; pfam13276 288705009058 Integrase core domain; Region: rve; pfam00665 288705009059 Integrase core domain; Region: rve_3; pfam13683 288705009060 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 288705009061 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 288705009062 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 288705009063 putative active site [active] 288705009064 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 288705009065 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 288705009066 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 288705009067 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 288705009068 replicative DNA helicase; Region: DnaB; TIGR00665 288705009069 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 288705009070 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 288705009071 Walker A motif; other site 288705009072 ATP binding site [chemical binding]; other site 288705009073 Walker B motif; other site 288705009074 DNA binding loops [nucleotide binding] 288705009075 hypothetical protein; Provisional; Region: PRK06771 288705009076 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 288705009077 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 288705009078 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 288705009079 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 288705009080 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 288705009081 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 288705009082 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 288705009083 dimer interface [polypeptide binding]; other site 288705009084 ssDNA binding site [nucleotide binding]; other site 288705009085 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288705009086 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 288705009087 metabolite-proton symporter; Region: 2A0106; TIGR00883 288705009088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288705009089 putative substrate translocation pore; other site 288705009090 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288705009091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705009092 dimer interface [polypeptide binding]; other site 288705009093 conserved gate region; other site 288705009094 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288705009095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705009096 ABC-ATPase subunit interface; other site 288705009097 putative PBP binding loops; other site 288705009098 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288705009099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288705009100 dimer interface [polypeptide binding]; other site 288705009101 conserved gate region; other site 288705009102 ABC-ATPase subunit interface; other site 288705009103 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 288705009104 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 288705009105 putative transposase OrfB; Reviewed; Region: PHA02517 288705009106 HTH-like domain; Region: HTH_21; pfam13276 288705009107 Integrase core domain; Region: rve; pfam00665 288705009108 Integrase core domain; Region: rve_3; pfam13683 288705009109 Transposase; Region: HTH_Tnp_1; cl17663 288705009110 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288705009111 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288705009112 DNA binding site [nucleotide binding] 288705009113 domain linker motif; other site 288705009114 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288705009115 ligand binding site [chemical binding]; other site 288705009116 dimerization interface [polypeptide binding]; other site 288705009117 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288705009118 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 288705009119 Predicted transcriptional regulators [Transcription]; Region: COG1733 288705009120 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 288705009121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288705009122 NADH(P)-binding; Region: NAD_binding_10; pfam13460 288705009123 NAD(P) binding site [chemical binding]; other site 288705009124 active site 288705009125 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 288705009126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288705009127 Predicted integral membrane protein [Function unknown]; Region: COG5650 288705009128 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288705009129 catalytic core [active] 288705009130 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 288705009131 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 288705009132 active site 288705009133 NTP binding site [chemical binding]; other site 288705009134 metal binding triad [ion binding]; metal-binding site 288705009135 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 288705009136 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288705009137 Zn2+ binding site [ion binding]; other site 288705009138 Mg2+ binding site [ion binding]; other site 288705009139 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 288705009140 active site 288705009141 Ap6A binding site [chemical binding]; other site 288705009142 nudix motif; other site 288705009143 metal binding site [ion binding]; metal-binding site 288705009144 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 288705009145 MviN-like protein; Region: MVIN; pfam03023 288705009146 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 288705009147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288705009148 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288705009149 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288705009150 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 288705009151 catalytic residues [active] 288705009152 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 288705009153 ParB-like nuclease domain; Region: ParBc; pfam02195 288705009154 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 288705009155 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288705009156 Magnesium ion binding site [ion binding]; other site 288705009157 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 288705009158 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 288705009159 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 288705009160 G-X-X-G motif; other site 288705009161 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 288705009162 RxxxH motif; other site 288705009163 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 288705009164 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 288705009165 Haemolytic domain; Region: Haemolytic; pfam01809 288705009166 Ribonuclease P; Region: Ribonuclease_P; cl00457 288705009167 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399