-- dump date   	20140620_024505
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
395491000001	GAF domain; Region: GAF; cl17456
395491000002	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
395491000003	Histidine kinase; Region: HisKA_3; pfam07730
395491000004	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491000005	ATP binding site [chemical binding]; other site
395491000006	Mg2+ binding site [ion binding]; other site
395491000007	G-X-G motif; other site
395491000008	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
395491000009	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491000010	putative ligand binding site [chemical binding]; other site
395491000011	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491000012	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491000013	Walker A/P-loop; other site
395491000014	ATP binding site [chemical binding]; other site
395491000015	Q-loop/lid; other site
395491000016	ABC transporter signature motif; other site
395491000017	Walker B; other site
395491000018	D-loop; other site
395491000019	H-loop/switch region; other site
395491000020	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491000021	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491000022	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491000023	TM-ABC transporter signature motif; other site
395491000024	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491000025	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491000026	TM-ABC transporter signature motif; other site
395491000027	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
395491000028	Strictosidine synthase; Region: Str_synth; pfam03088
395491000029	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395491000030	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491000031	active site
395491000032	metal binding site [ion binding]; metal-binding site
395491000033	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
395491000034	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
395491000035	Transposase; Region: HTH_Tnp_1; pfam01527
395491000036	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
395491000037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491000038	putative substrate translocation pore; other site
395491000039	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491000040	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491000041	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491000042	Epoxide hydrolase N terminus; Region: EHN; pfam06441
395491000043	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491000044	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
395491000045	Ligand binding site; other site
395491000046	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
395491000047	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
395491000048	XdhC Rossmann domain; Region: XdhC_C; pfam13478
395491000049	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
395491000050	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
395491000051	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395491000052	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
395491000053	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
395491000054	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
395491000055	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395491000056	catalytic loop [active]
395491000057	iron binding site [ion binding]; other site
395491000058	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
395491000059	Creatinine amidohydrolase; Region: Creatininase; pfam02633
395491000060	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
395491000061	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491000062	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491000063	dimerization interface [polypeptide binding]; other site
395491000064	NMT1/THI5 like; Region: NMT1; pfam09084
395491000065	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395491000066	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395491000067	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395491000068	Walker A/P-loop; other site
395491000069	ATP binding site [chemical binding]; other site
395491000070	Q-loop/lid; other site
395491000071	ABC transporter signature motif; other site
395491000072	Walker B; other site
395491000073	D-loop; other site
395491000074	H-loop/switch region; other site
395491000075	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491000076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000077	dimer interface [polypeptide binding]; other site
395491000078	conserved gate region; other site
395491000079	ABC-ATPase subunit interface; other site
395491000080	cytosine deaminase-like protein; Validated; Region: PRK07583
395491000081	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
395491000082	active site
395491000083	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
395491000084	FAD binding domain; Region: FAD_binding_4; pfam01565
395491000085	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
395491000086	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491000087	Putative translation initiation inhibitor, yjgF family [Translation, ribosomal structure and biogenesis]; Region: TdcF; COG0251
395491000088	homotrimer interaction site [polypeptide binding]; other site
395491000089	putative active site [active]
395491000090	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
395491000091	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491000092	dimerization interface [polypeptide binding]; other site
395491000093	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491000094	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491000095	dimer interface [polypeptide binding]; other site
395491000096	putative CheW interface [polypeptide binding]; other site
395491000097	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
395491000098	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
395491000099	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
395491000100	ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049
395491000101	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395491000102	N-terminal plug; other site
395491000103	ligand-binding site [chemical binding]; other site
395491000104	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
395491000105	oligomeric interface; other site
395491000106	putative active site [active]
395491000107	homodimer interface [polypeptide binding]; other site
395491000108	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
395491000109	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491000110	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491000111	Porcine arterivirus-type cysteine proteinase alpha; Region: Peptidase_C31; pfam05410
395491000112	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491000113	Divergent AAA domain; Region: AAA_4; pfam04326
395491000114	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
395491000115	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
395491000116	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491000117	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491000118	metal binding site [ion binding]; metal-binding site
395491000119	active site
395491000120	I-site; other site
395491000121	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491000122	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491000123	DNA-binding site [nucleotide binding]; DNA binding site
395491000124	FCD domain; Region: FCD; pfam07729
395491000125	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491000126	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
395491000127	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491000128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000129	dimer interface [polypeptide binding]; other site
395491000130	conserved gate region; other site
395491000131	putative PBP binding loops; other site
395491000132	ABC-ATPase subunit interface; other site
395491000133	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491000134	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000135	dimer interface [polypeptide binding]; other site
395491000136	conserved gate region; other site
395491000137	putative PBP binding loops; other site
395491000138	ABC-ATPase subunit interface; other site
395491000139	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491000140	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
395491000141	inhibitor site; inhibition site
395491000142	active site
395491000143	dimer interface [polypeptide binding]; other site
395491000144	catalytic residue [active]
395491000145	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
395491000146	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491000147	Walker A/P-loop; other site
395491000148	ATP binding site [chemical binding]; other site
395491000149	Q-loop/lid; other site
395491000150	ABC transporter signature motif; other site
395491000151	Walker B; other site
395491000152	D-loop; other site
395491000153	H-loop/switch region; other site
395491000154	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395491000155	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
395491000156	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491000157	Walker A/P-loop; other site
395491000158	ATP binding site [chemical binding]; other site
395491000159	Q-loop/lid; other site
395491000160	ABC transporter signature motif; other site
395491000161	Walker B; other site
395491000162	D-loop; other site
395491000163	H-loop/switch region; other site
395491000164	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395491000165	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491000166	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
395491000167	inhibitor site; inhibition site
395491000168	active site
395491000169	dimer interface [polypeptide binding]; other site
395491000170	catalytic residue [active]
395491000171	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
395491000172	Transcriptional regulator [Transcription]; Region: IclR; COG1414
395491000173	Bacterial transcriptional regulator; Region: IclR; pfam01614
395491000174	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491000175	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
395491000176	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
395491000177	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
395491000178	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
395491000179	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491000180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000181	dimer interface [polypeptide binding]; other site
395491000182	conserved gate region; other site
395491000183	putative PBP binding loops; other site
395491000184	ABC-ATPase subunit interface; other site
395491000185	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491000186	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
395491000187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000188	dimer interface [polypeptide binding]; other site
395491000189	conserved gate region; other site
395491000190	putative PBP binding loops; other site
395491000191	ABC-ATPase subunit interface; other site
395491000192	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
395491000193	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491000194	Walker A/P-loop; other site
395491000195	ATP binding site [chemical binding]; other site
395491000196	Q-loop/lid; other site
395491000197	ABC transporter signature motif; other site
395491000198	Walker B; other site
395491000199	D-loop; other site
395491000200	H-loop/switch region; other site
395491000201	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491000202	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
395491000203	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491000204	Walker A/P-loop; other site
395491000205	ATP binding site [chemical binding]; other site
395491000206	Q-loop/lid; other site
395491000207	ABC transporter signature motif; other site
395491000208	Walker B; other site
395491000209	D-loop; other site
395491000210	H-loop/switch region; other site
395491000211	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395491000212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395491000213	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491000214	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
395491000215	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395491000216	ligand binding site [chemical binding]; other site
395491000217	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491000218	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491000219	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491000220	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
395491000221	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491000222	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491000223	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491000224	putative effector binding pocket; other site
395491000225	dimerization interface [polypeptide binding]; other site
395491000226	RES domain; Region: RES; pfam08808
395491000227	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
395491000228	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
395491000229	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
395491000230	active site
395491000231	catalytic site [active]
395491000232	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
395491000233	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
395491000234	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491000235	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491000236	DNA binding site [nucleotide binding]
395491000237	domain linker motif; other site
395491000238	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
395491000239	putative dimerization interface [polypeptide binding]; other site
395491000240	putative ligand binding site [chemical binding]; other site
395491000241	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395491000242	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491000243	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491000244	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
395491000245	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000246	dimer interface [polypeptide binding]; other site
395491000247	conserved gate region; other site
395491000248	putative PBP binding loops; other site
395491000249	ABC-ATPase subunit interface; other site
395491000250	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491000251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000252	dimer interface [polypeptide binding]; other site
395491000253	conserved gate region; other site
395491000254	putative PBP binding loops; other site
395491000255	ABC-ATPase subunit interface; other site
395491000256	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491000257	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491000258	Walker A/P-loop; other site
395491000259	ATP binding site [chemical binding]; other site
395491000260	Q-loop/lid; other site
395491000261	ABC transporter signature motif; other site
395491000262	Walker B; other site
395491000263	D-loop; other site
395491000264	H-loop/switch region; other site
395491000265	TOBE domain; Region: TOBE_2; pfam08402
395491000266	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
395491000267	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
395491000268	substrate binding [chemical binding]; other site
395491000269	active site
395491000270	MarR family; Region: MarR_2; pfam12802
395491000271	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491000272	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395491000273	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491000274	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491000275	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491000276	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491000277	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491000278	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000279	dimer interface [polypeptide binding]; other site
395491000280	conserved gate region; other site
395491000281	putative PBP binding loops; other site
395491000282	ABC-ATPase subunit interface; other site
395491000283	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491000284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000285	dimer interface [polypeptide binding]; other site
395491000286	conserved gate region; other site
395491000287	putative PBP binding loops; other site
395491000288	ABC-ATPase subunit interface; other site
395491000289	MarR family; Region: MarR; pfam01047
395491000290	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491000291	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395491000292	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491000293	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491000294	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491000295	Walker A/P-loop; other site
395491000296	ATP binding site [chemical binding]; other site
395491000297	Q-loop/lid; other site
395491000298	ABC transporter signature motif; other site
395491000299	Walker B; other site
395491000300	D-loop; other site
395491000301	H-loop/switch region; other site
395491000302	TOBE domain; Region: TOBE_2; pfam08402
395491000303	ProQ/FINO family; Region: ProQ; pfam04352
395491000304	pantoate--beta-alanine ligase; Region: panC; TIGR00018
395491000305	Pantoate-beta-alanine ligase; Region: PanC; cd00560
395491000306	active site
395491000307	ATP-binding site [chemical binding]; other site
395491000308	pantoate-binding site; other site
395491000309	HXXH motif; other site
395491000310	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
395491000311	active site
395491000312	oligomerization interface [polypeptide binding]; other site
395491000313	metal binding site [ion binding]; metal-binding site
395491000314	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491000315	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491000316	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
395491000317	dimerization interface [polypeptide binding]; other site
395491000318	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
395491000319	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
395491000320	dimer interface [polypeptide binding]; other site
395491000321	active site
395491000322	heme binding site [chemical binding]; other site
395491000323	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
395491000324	Protein of unknown function (DUF3299); Region: DUF3299; cl01387
395491000325	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
395491000326	G-X-G motif; other site
395491000327	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
395491000328	Predicted transcriptional regulators [Transcription]; Region: COG1733
395491000329	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395491000330	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395491000331	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
395491000332	NADP binding site [chemical binding]; other site
395491000333	dimer interface [polypeptide binding]; other site
395491000334	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
395491000335	active site
395491000336	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
395491000337	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
395491000338	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
395491000339	acyl-activating enzyme (AAE) consensus motif; other site
395491000340	AMP binding site [chemical binding]; other site
395491000341	active site
395491000342	CoA binding site [chemical binding]; other site
395491000343	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
395491000344	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
395491000345	dimer interface [polypeptide binding]; other site
395491000346	active site
395491000347	Uncharacterized conserved protein [Function unknown]; Region: COG2128
395491000348	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
395491000349	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491000350	NADH(P)-binding; Region: NAD_binding_10; pfam13460
395491000351	NAD(P) binding site [chemical binding]; other site
395491000352	active site
395491000353	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
395491000354	methionine gamma-lyase; Validated; Region: PRK07049
395491000355	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
395491000356	homodimer interface [polypeptide binding]; other site
395491000357	substrate-cofactor binding pocket; other site
395491000358	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491000359	catalytic residue [active]
395491000360	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
395491000361	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
395491000362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491000363	S-adenosylmethionine binding site [chemical binding]; other site
395491000364	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395491000365	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491000366	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491000367	Walker A/P-loop; other site
395491000368	ATP binding site [chemical binding]; other site
395491000369	Q-loop/lid; other site
395491000370	ABC transporter signature motif; other site
395491000371	Walker B; other site
395491000372	D-loop; other site
395491000373	H-loop/switch region; other site
395491000374	TOBE domain; Region: TOBE_2; pfam08402
395491000375	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
395491000376	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491000377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000378	dimer interface [polypeptide binding]; other site
395491000379	conserved gate region; other site
395491000380	putative PBP binding loops; other site
395491000381	ABC-ATPase subunit interface; other site
395491000382	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491000383	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000384	dimer interface [polypeptide binding]; other site
395491000385	conserved gate region; other site
395491000386	putative PBP binding loops; other site
395491000387	ABC-ATPase subunit interface; other site
395491000388	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491000389	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491000390	DAK2 domain; Region: Dak2; cl03685
395491000391	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
395491000392	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
395491000393	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491000394	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491000395	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491000396	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491000397	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491000398	TM-ABC transporter signature motif; other site
395491000399	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491000400	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491000401	Walker A/P-loop; other site
395491000402	ATP binding site [chemical binding]; other site
395491000403	Q-loop/lid; other site
395491000404	ABC transporter signature motif; other site
395491000405	Walker B; other site
395491000406	D-loop; other site
395491000407	H-loop/switch region; other site
395491000408	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491000409	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054
395491000410	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
395491000411	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491000412	ligand binding site [chemical binding]; other site
395491000413	dimerization interface [polypeptide binding]; other site
395491000414	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
395491000415	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
395491000416	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
395491000417	Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207
395491000418	dimer interface [polypeptide binding]; other site
395491000419	active site
395491000420	catalytic residue [active]
395491000421	metal binding site [ion binding]; metal-binding site
395491000422	transcriptional regulator NanR; Provisional; Region: PRK03837
395491000423	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491000424	DNA-binding site [nucleotide binding]; DNA binding site
395491000425	FCD domain; Region: FCD; pfam07729
395491000426	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
395491000427	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491000428	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
395491000429	ligand binding site [chemical binding]; other site
395491000430	flexible hinge region; other site
395491000431	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491000432	PAS domain S-box; Region: sensory_box; TIGR00229
395491000433	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491000434	putative active site [active]
395491000435	heme pocket [chemical binding]; other site
395491000436	PAS domain S-box; Region: sensory_box; TIGR00229
395491000437	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491000438	putative active site [active]
395491000439	heme pocket [chemical binding]; other site
395491000440	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395491000441	Histidine kinase; Region: HisKA_2; pfam07568
395491000442	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491000443	ATP binding site [chemical binding]; other site
395491000444	Mg2+ binding site [ion binding]; other site
395491000445	G-X-G motif; other site
395491000446	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491000447	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491000448	DNA-binding site [nucleotide binding]; DNA binding site
395491000449	FCD domain; Region: FCD; pfam07729
395491000450	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
395491000451	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
395491000452	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
395491000453	DctM-like transporters; Region: DctM; pfam06808
395491000454	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
395491000455	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
395491000456	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
395491000457	putative NAD(P) binding site [chemical binding]; other site
395491000458	catalytic Zn binding site [ion binding]; other site
395491000459	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491000460	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491000461	DNA-binding site [nucleotide binding]; DNA binding site
395491000462	FCD domain; Region: FCD; pfam07729
395491000463	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491000464	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
395491000465	inhibitor site; inhibition site
395491000466	active site
395491000467	dimer interface [polypeptide binding]; other site
395491000468	catalytic residue [active]
395491000469	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
395491000470	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491000471	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491000472	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
395491000473	putative Zn2+ binding site [ion binding]; other site
395491000474	putative DNA binding site [nucleotide binding]; other site
395491000475	AsnC family; Region: AsnC_trans_reg; pfam01037
395491000476	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
395491000477	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
395491000478	active site
395491000479	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395491000480	dimer interface [polypeptide binding]; other site
395491000481	substrate binding site [chemical binding]; other site
395491000482	catalytic residues [active]
395491000483	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
395491000484	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395491000485	hydroxyglutarate oxidase; Provisional; Region: PRK11728
395491000486	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491000487	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491000488	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
395491000489	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
395491000490	metal binding site [ion binding]; metal-binding site
395491000491	putative dimer interface [polypeptide binding]; other site
395491000492	allantoate amidohydrolase; Reviewed; Region: PRK12890
395491000493	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
395491000494	active site
395491000495	metal binding site [ion binding]; metal-binding site
395491000496	dimer interface [polypeptide binding]; other site
395491000497	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
395491000498	catalytic residue [active]
395491000499	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491000500	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491000501	putative DNA binding site [nucleotide binding]; other site
395491000502	putative Zn2+ binding site [ion binding]; other site
395491000503	AsnC family; Region: AsnC_trans_reg; pfam01037
395491000504	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
395491000505	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395491000506	inhibitor-cofactor binding pocket; inhibition site
395491000507	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491000508	catalytic residue [active]
395491000509	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
395491000510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491000511	non-specific DNA binding site [nucleotide binding]; other site
395491000512	salt bridge; other site
395491000513	sequence-specific DNA binding site [nucleotide binding]; other site
395491000514	Cupin domain; Region: Cupin_2; pfam07883
395491000515	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
395491000516	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476
395491000517	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
395491000518	TadE-like protein; Region: TadE; pfam07811
395491000519	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
395491000520	TadE-like protein; Region: TadE; pfam07811
395491000521	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
395491000522	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
395491000523	RNA polymerase sigma factor; Provisional; Region: PRK11922
395491000524	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491000525	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491000526	DNA binding residues [nucleotide binding]
395491000527	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
395491000528	Predicted outer membrane protein [Function unknown]; Region: COG3652
395491000529	Uncharacterized conserved protein [Function unknown]; Region: COG3189
395491000530	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395491000531	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
395491000532	NAD(P) binding site [chemical binding]; other site
395491000533	catalytic residues [active]
395491000534	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
395491000535	alpha hydroxysteroid dehydrogenase (3alpha_HSD), classical (c) SDRs; Region: 3alpha_HSD_SDR_c; cd05328
395491000536	NAD binding site [chemical binding]; other site
395491000537	active site
395491000538	homodimer interface [polypeptide binding]; other site
395491000539	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395491000540	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395491000541	TM-ABC transporter signature motif; other site
395491000542	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491000543	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395491000544	TM-ABC transporter signature motif; other site
395491000545	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
395491000546	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395491000547	Walker A/P-loop; other site
395491000548	ATP binding site [chemical binding]; other site
395491000549	Q-loop/lid; other site
395491000550	ABC transporter signature motif; other site
395491000551	Walker B; other site
395491000552	D-loop; other site
395491000553	H-loop/switch region; other site
395491000554	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395491000555	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395491000556	Walker A/P-loop; other site
395491000557	ATP binding site [chemical binding]; other site
395491000558	Q-loop/lid; other site
395491000559	ABC transporter signature motif; other site
395491000560	Walker B; other site
395491000561	D-loop; other site
395491000562	H-loop/switch region; other site
395491000563	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395491000564	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337
395491000565	putative ligand binding site [chemical binding]; other site
395491000566	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395491000567	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
395491000568	NAD(P) binding site [chemical binding]; other site
395491000569	catalytic residues [active]
395491000570	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491000571	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491000572	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491000573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491000574	ATP binding site [chemical binding]; other site
395491000575	Mg2+ binding site [ion binding]; other site
395491000576	G-X-G motif; other site
395491000577	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491000578	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491000579	active site
395491000580	phosphorylation site [posttranslational modification]
395491000581	intermolecular recognition site; other site
395491000582	dimerization interface [polypeptide binding]; other site
395491000583	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491000584	DNA binding site [nucleotide binding]
395491000585	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
395491000586	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491000587	cyclase homology domain; Region: CHD; cd07302
395491000588	nucleotidyl binding site; other site
395491000589	metal binding site [ion binding]; metal-binding site
395491000590	dimer interface [polypeptide binding]; other site
395491000591	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491000592	MarR family; Region: MarR_2; pfam12802
395491000593	acyl-CoA synthetase; Validated; Region: PRK09088
395491000594	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
395491000595	acyl-activating enzyme (AAE) consensus motif; other site
395491000596	AMP binding site [chemical binding]; other site
395491000597	active site
395491000598	CoA binding site [chemical binding]; other site
395491000599	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
395491000600	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395491000601	substrate binding site [chemical binding]; other site
395491000602	oxyanion hole (OAH) forming residues; other site
395491000603	trimer interface [polypeptide binding]; other site
395491000604	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
395491000605	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
395491000606	catalytic Zn binding site [ion binding]; other site
395491000607	NAD binding site [chemical binding]; other site
395491000608	structural Zn binding site [ion binding]; other site
395491000609	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
395491000610	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
395491000611	NAD(P) binding site [chemical binding]; other site
395491000612	catalytic residues [active]
395491000613	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
395491000614	PAS fold; Region: PAS_4; pfam08448
395491000615	PAS fold; Region: PAS_7; pfam12860
395491000616	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491000617	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491000618	metal binding site [ion binding]; metal-binding site
395491000619	active site
395491000620	I-site; other site
395491000621	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
395491000622	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
395491000623	putative molybdopterin cofactor binding site [chemical binding]; other site
395491000624	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
395491000625	putative molybdopterin cofactor binding site; other site
395491000626	Helix-turn-helix domain; Region: HTH_18; pfam12833
395491000627	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
395491000628	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
395491000629	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
395491000630	putative active site [active]
395491000631	putative FMN binding site [chemical binding]; other site
395491000632	putative substrate binding site [chemical binding]; other site
395491000633	putative catalytic residue [active]
395491000634	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395491000635	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491000636	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
395491000637	Walker A/P-loop; other site
395491000638	ATP binding site [chemical binding]; other site
395491000639	Q-loop/lid; other site
395491000640	ABC transporter signature motif; other site
395491000641	Walker B; other site
395491000642	D-loop; other site
395491000643	H-loop/switch region; other site
395491000644	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491000645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000646	dimer interface [polypeptide binding]; other site
395491000647	conserved gate region; other site
395491000648	putative PBP binding loops; other site
395491000649	ABC-ATPase subunit interface; other site
395491000650	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
395491000651	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
395491000652	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
395491000653	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491000654	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491000655	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
395491000656	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
395491000657	putative active site [active]
395491000658	putative FMN binding site [chemical binding]; other site
395491000659	putative substrate binding site [chemical binding]; other site
395491000660	putative catalytic residue [active]
395491000661	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
395491000662	Ligand binding site [chemical binding]; other site
395491000663	Electron transfer flavoprotein domain; Region: ETF; pfam01012
395491000664	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
395491000665	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
395491000666	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
395491000667	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
395491000668	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
395491000669	substrate binding site [chemical binding]; other site
395491000670	catalytic Zn binding site [ion binding]; other site
395491000671	NAD binding site [chemical binding]; other site
395491000672	structural Zn binding site [ion binding]; other site
395491000673	dimer interface [polypeptide binding]; other site
395491000674	S-formylglutathione hydrolase; Region: PLN02442
395491000675	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
395491000676	glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417
395491000677	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491000678	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491000679	DNA-binding site [nucleotide binding]; DNA binding site
395491000680	FCD domain; Region: FCD; pfam07729
395491000681	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491000682	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
395491000683	inhibitor site; inhibition site
395491000684	active site
395491000685	dimer interface [polypeptide binding]; other site
395491000686	catalytic residue [active]
395491000687	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395491000688	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
395491000689	NAD(P) binding site [chemical binding]; other site
395491000690	catalytic residues [active]
395491000691	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
395491000692	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491000693	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
395491000694	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
395491000695	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
395491000696	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
395491000697	Walker A/P-loop; other site
395491000698	ATP binding site [chemical binding]; other site
395491000699	Q-loop/lid; other site
395491000700	ABC transporter signature motif; other site
395491000701	Walker B; other site
395491000702	D-loop; other site
395491000703	H-loop/switch region; other site
395491000704	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000705	dimer interface [polypeptide binding]; other site
395491000706	conserved gate region; other site
395491000707	putative PBP binding loops; other site
395491000708	ABC-ATPase subunit interface; other site
395491000709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000710	dimer interface [polypeptide binding]; other site
395491000711	conserved gate region; other site
395491000712	ABC-ATPase subunit interface; other site
395491000713	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
395491000714	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
395491000715	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395491000716	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
395491000717	conserved cys residue [active]
395491000718	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491000719	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
395491000720	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
395491000721	active site
395491000722	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
395491000723	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
395491000724	FAD binding pocket [chemical binding]; other site
395491000725	FAD binding motif [chemical binding]; other site
395491000726	phosphate binding motif [ion binding]; other site
395491000727	beta-alpha-beta structure motif; other site
395491000728	NAD binding pocket [chemical binding]; other site
395491000729	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395491000730	catalytic loop [active]
395491000731	iron binding site [ion binding]; other site
395491000732	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
395491000733	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
395491000734	[2Fe-2S] cluster binding site [ion binding]; other site
395491000735	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
395491000736	putative alpha subunit interface [polypeptide binding]; other site
395491000737	putative active site [active]
395491000738	putative substrate binding site [chemical binding]; other site
395491000739	Fe binding site [ion binding]; other site
395491000740	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491000741	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491000742	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491000743	dimerization interface [polypeptide binding]; other site
395491000744	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395491000745	putative trimer interface [polypeptide binding]; other site
395491000746	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
395491000747	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
395491000748	trimer interface [polypeptide binding]; other site
395491000749	active site
395491000750	substrate binding site [chemical binding]; other site
395491000751	putative CoA binding site [chemical binding]; other site
395491000752	CoA binding site [chemical binding]; other site
395491000753	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491000754	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491000755	metal binding site [ion binding]; metal-binding site
395491000756	active site
395491000757	I-site; other site
395491000758	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491000759	Methyltransferase domain; Region: Methyltransf_25; pfam13649
395491000760	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491000761	NmrA-like family; Region: NmrA; pfam05368
395491000762	NAD(P) binding site [chemical binding]; other site
395491000763	active site
395491000764	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491000765	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491000766	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491000767	putative effector binding pocket; other site
395491000768	dimerization interface [polypeptide binding]; other site
395491000769	Uncharacterized conserved protein [Function unknown]; Region: COG4925
395491000770	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
395491000771	clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934
395491000772	NADP binding site [chemical binding]; other site
395491000773	homotetramer interface [polypeptide binding]; other site
395491000774	homodimer interface [polypeptide binding]; other site
395491000775	active site
395491000776	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
395491000777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491000778	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491000779	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491000780	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395491000781	putative effector binding pocket; other site
395491000782	putative dimerization interface [polypeptide binding]; other site
395491000783	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491000784	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491000785	putative DNA binding site [nucleotide binding]; other site
395491000786	dimerization interface [polypeptide binding]; other site
395491000787	putative Zn2+ binding site [ion binding]; other site
395491000788	AsnC family; Region: AsnC_trans_reg; pfam01037
395491000789	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
395491000790	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
395491000791	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
395491000792	Glutamate binding site [chemical binding]; other site
395491000793	NAD binding site [chemical binding]; other site
395491000794	catalytic residues [active]
395491000795	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
395491000796	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
395491000797	active site pocket [active]
395491000798	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
395491000799	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
395491000800	active site pocket [active]
395491000801	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
395491000802	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
395491000803	active site pocket [active]
395491000804	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491000805	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491000806	DNA-binding site [nucleotide binding]; DNA binding site
395491000807	FCD domain; Region: FCD; pfam07729
395491000808	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491000809	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491000810	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491000811	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000812	dimer interface [polypeptide binding]; other site
395491000813	conserved gate region; other site
395491000814	putative PBP binding loops; other site
395491000815	ABC-ATPase subunit interface; other site
395491000816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395491000817	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491000818	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000819	dimer interface [polypeptide binding]; other site
395491000820	conserved gate region; other site
395491000821	putative PBP binding loops; other site
395491000822	ABC-ATPase subunit interface; other site
395491000823	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491000824	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491000825	Walker A/P-loop; other site
395491000826	ATP binding site [chemical binding]; other site
395491000827	Q-loop/lid; other site
395491000828	ABC transporter signature motif; other site
395491000829	Walker B; other site
395491000830	D-loop; other site
395491000831	H-loop/switch region; other site
395491000832	TOBE domain; Region: TOBE; pfam03459
395491000833	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
395491000834	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
395491000835	active site pocket [active]
395491000836	hypothetical protein; Validated; Region: PRK06201
395491000837	hypothetical protein; Validated; Region: PRK08245
395491000838	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491000839	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491000840	DNA binding site [nucleotide binding]
395491000841	domain linker motif; other site
395491000842	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395491000843	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491000844	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491000845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000846	dimer interface [polypeptide binding]; other site
395491000847	conserved gate region; other site
395491000848	putative PBP binding loops; other site
395491000849	ABC-ATPase subunit interface; other site
395491000850	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491000851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491000852	dimer interface [polypeptide binding]; other site
395491000853	conserved gate region; other site
395491000854	putative PBP binding loops; other site
395491000855	ABC-ATPase subunit interface; other site
395491000856	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
395491000857	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
395491000858	substrate binding [chemical binding]; other site
395491000859	active site
395491000860	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
395491000861	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
395491000862	Transposase; Region: HTH_Tnp_1; pfam01527
395491000863	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
395491000864	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
395491000865	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
395491000866	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
395491000867	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395491000868	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395491000869	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
395491000870	DEAD/DEAH box helicase; Region: DEAD; pfam00270
395491000871	ATP binding site [chemical binding]; other site
395491000872	putative Mg++ binding site [ion binding]; other site
395491000873	helicase superfamily c-terminal domain; Region: HELICc; smart00490
395491000874	nucleotide binding region [chemical binding]; other site
395491000875	ATP-binding site [chemical binding]; other site
395491000876	Domain of unknown function (DUF4297); Region: DUF4297; pfam14130
395491000877	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
395491000878	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
395491000879	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
395491000880	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
395491000881	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
395491000882	HTH-like domain; Region: HTH_21; pfam13276
395491000883	Integrase core domain; Region: rve; pfam00665
395491000884	Integrase core domain; Region: rve_3; pfam13683
395491000885	Transposase; Region: HTH_Tnp_1; pfam01527
395491000886	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491000887	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
395491000888	putative ligand binding site [chemical binding]; other site
395491000889	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491000890	non-specific DNA binding site [nucleotide binding]; other site
395491000891	salt bridge; other site
395491000892	sequence-specific DNA binding site [nucleotide binding]; other site
395491000893	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
395491000894	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
395491000895	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
395491000896	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395491000897	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395491000898	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
395491000899	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
395491000900	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
395491000901	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395491000902	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395491000903	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
395491000904	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
395491000905	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
395491000906	Transposase; Region: HTH_Tnp_1; pfam01527
395491000907	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
395491000908	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395491000909	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
395491000910	putative active site [active]
395491000911	putative catalytic site [active]
395491000912	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
395491000913	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
395491000914	glutaminase active site [active]
395491000915	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
395491000916	dimer interface [polypeptide binding]; other site
395491000917	active site
395491000918	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
395491000919	dimer interface [polypeptide binding]; other site
395491000920	active site
395491000921	maltose O-acetyltransferase; Provisional; Region: PRK10092
395491000922	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
395491000923	active site
395491000924	substrate binding site [chemical binding]; other site
395491000925	trimer interface [polypeptide binding]; other site
395491000926	CoA binding site [chemical binding]; other site
395491000927	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
395491000928	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395491000929	dimer interface [polypeptide binding]; other site
395491000930	active site
395491000931	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
395491000932	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491000933	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491000934	The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462
395491000935	putative substrate binding pocket [chemical binding]; other site
395491000936	putative dimerization interface [polypeptide binding]; other site
395491000937	acyltransferase NodA; Provisional; Region: PRK00756
395491000938	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
395491000939	chitooligosaccharide deacetylase NodB; Region: nodulat_NodB; TIGR04243
395491000940	chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242
395491000941	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
395491000942	DXD motif; other site
395491000943	nodulation factor exporter subunit NodI; Provisional; Region: PRK13536
395491000944	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
395491000945	Walker A/P-loop; other site
395491000946	ATP binding site [chemical binding]; other site
395491000947	Q-loop/lid; other site
395491000948	ABC transporter signature motif; other site
395491000949	Walker B; other site
395491000950	D-loop; other site
395491000951	H-loop/switch region; other site
395491000952	ABC-2 type transporter; Region: ABC2_membrane; cl17235
395491000953	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
395491000954	NifT/FixU protein; Region: NifT; pfam06988
395491000955	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
395491000956	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
395491000957	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395491000958	FeS/SAM binding site; other site
395491000959	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
395491000960	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
395491000961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491000962	Walker A motif; other site
395491000963	ATP binding site [chemical binding]; other site
395491000964	Walker B motif; other site
395491000965	arginine finger; other site
395491000966	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395491000967	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
395491000968	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
395491000969	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395491000970	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
395491000971	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
395491000972	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
395491000973	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
395491000974	Ligand binding site [chemical binding]; other site
395491000975	Electron transfer flavoprotein domain; Region: ETF; pfam01012
395491000976	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
395491000977	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
395491000978	Nucleotide-binding sites [chemical binding]; other site
395491000979	Walker A motif; other site
395491000980	Switch I region of nucleotide binding site; other site
395491000981	Fe4S4 binding sites [ion binding]; other site
395491000982	Switch II region of nucleotide binding site; other site
395491000983	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
395491000984	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
395491000985	MoFe protein alpha/beta subunit interactions; other site
395491000986	Alpha subunit P cluster binding residues; other site
395491000987	FeMoco binding residues [chemical binding]; other site
395491000988	MoFe protein alpha subunit/Fe protein contacts; other site
395491000989	MoFe protein dimer/ dimer interactions; other site
395491000990	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
395491000991	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
395491000992	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
395491000993	MoFe protein beta/alpha subunit interactions; other site
395491000994	Beta subunit P cluster binding residues; other site
395491000995	MoFe protein beta subunit/Fe protein contacts; other site
395491000996	MoFe protein dimer/ dimer interactions; other site
395491000997	nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478
395491000998	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
395491000999	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
395491001000	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
395491001001	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395491001002	MarR family; Region: MarR_2; cl17246
395491001003	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491001004	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
395491001005	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491001006	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491001007	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
395491001008	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001009	dimer interface [polypeptide binding]; other site
395491001010	conserved gate region; other site
395491001011	putative PBP binding loops; other site
395491001012	ABC-ATPase subunit interface; other site
395491001013	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491001014	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001015	dimer interface [polypeptide binding]; other site
395491001016	conserved gate region; other site
395491001017	putative PBP binding loops; other site
395491001018	ABC-ATPase subunit interface; other site
395491001019	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491001020	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491001021	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491001022	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491001023	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491001024	Walker A/P-loop; other site
395491001025	ATP binding site [chemical binding]; other site
395491001026	Q-loop/lid; other site
395491001027	ABC transporter signature motif; other site
395491001028	Walker B; other site
395491001029	D-loop; other site
395491001030	H-loop/switch region; other site
395491001031	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001032	dimerization interface [polypeptide binding]; other site
395491001033	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491001034	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491001035	dimer interface [polypeptide binding]; other site
395491001036	putative CheW interface [polypeptide binding]; other site
395491001037	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491001038	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395491001039	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395491001040	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
395491001041	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395491001042	catalytic residue [active]
395491001043	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
395491001044	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491001045	motif II; other site
395491001046	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491001047	Coenzyme A binding pocket [chemical binding]; other site
395491001048	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
395491001049	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
395491001050	putative active site [active]
395491001051	catalytic site [active]
395491001052	putative metal binding site [ion binding]; other site
395491001053	oligomer interface [polypeptide binding]; other site
395491001054	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
395491001055	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
395491001056	Transposase; Region: DDE_Tnp_ISL3; pfam01610
395491001057	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
395491001058	Transposase; Region: DDE_Tnp_ISL3; pfam01610
395491001059	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491001060	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491001061	ligand binding site [chemical binding]; other site
395491001062	flexible hinge region; other site
395491001063	cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847
395491001064	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395491001065	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
395491001066	metal-binding site [ion binding]
395491001067	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395491001068	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
395491001069	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
395491001070	FixH; Region: FixH; pfam05751
395491001071	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
395491001072	4Fe-4S binding domain; Region: Fer4_5; pfam12801
395491001073	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
395491001074	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
395491001075	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
395491001076	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
395491001077	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
395491001078	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
395491001079	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
395491001080	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
395491001081	Low-spin heme binding site [chemical binding]; other site
395491001082	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
395491001083	Putative water exit pathway; other site
395491001084	Binuclear center (active site) [active]
395491001085	Putative proton exit pathway; other site
395491001086	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491001087	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491001088	DNA-binding site [nucleotide binding]; DNA binding site
395491001089	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
395491001090	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491001091	non-specific DNA binding site [nucleotide binding]; other site
395491001092	salt bridge; other site
395491001093	sequence-specific DNA binding site [nucleotide binding]; other site
395491001094	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491001095	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491001096	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
395491001097	dimerization interface [polypeptide binding]; other site
395491001098	substrate binding pocket [chemical binding]; other site
395491001099	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491001100	non-specific DNA binding site [nucleotide binding]; other site
395491001101	salt bridge; other site
395491001102	sequence-specific DNA binding site [nucleotide binding]; other site
395491001103	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491001104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491001105	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
395491001106	dimerization interface [polypeptide binding]; other site
395491001107	substrate binding pocket [chemical binding]; other site
395491001108	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
395491001109	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
395491001110	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
395491001111	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
395491001112	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395491001113	Walker A motif; other site
395491001114	ATP binding site [chemical binding]; other site
395491001115	Walker B motif; other site
395491001116	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
395491001117	MobA/MobL family; Region: MobA_MobL; pfam03389
395491001118	AAA domain; Region: AAA_30; pfam13604
395491001119	Family description; Region: UvrD_C_2; pfam13538
395491001120	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001121	dimerization interface [polypeptide binding]; other site
395491001122	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491001123	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491001124	dimer interface [polypeptide binding]; other site
395491001125	putative CheW interface [polypeptide binding]; other site
395491001126	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491001127	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
395491001128	DNA interaction; other site
395491001129	Metal-binding active site; metal-binding site
395491001130	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491001131	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
395491001132	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
395491001133	active site pocket [active]
395491001134	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491001135	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491001136	DNA-binding site [nucleotide binding]; DNA binding site
395491001137	FCD domain; Region: FCD; pfam07729
395491001138	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
395491001139	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
395491001140	ligand binding site [chemical binding]; other site
395491001141	NAD binding site [chemical binding]; other site
395491001142	dimerization interface [polypeptide binding]; other site
395491001143	catalytic site [active]
395491001144	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491001145	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491001146	Walker A/P-loop; other site
395491001147	ATP binding site [chemical binding]; other site
395491001148	Q-loop/lid; other site
395491001149	ABC transporter signature motif; other site
395491001150	Walker B; other site
395491001151	D-loop; other site
395491001152	H-loop/switch region; other site
395491001153	TOBE domain; Region: TOBE_2; pfam08402
395491001154	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491001155	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491001156	Walker A/P-loop; other site
395491001157	ATP binding site [chemical binding]; other site
395491001158	Q-loop/lid; other site
395491001159	ABC transporter signature motif; other site
395491001160	Walker B; other site
395491001161	D-loop; other site
395491001162	H-loop/switch region; other site
395491001163	TOBE domain; Region: TOBE_2; pfam08402
395491001164	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491001165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001166	dimer interface [polypeptide binding]; other site
395491001167	conserved gate region; other site
395491001168	putative PBP binding loops; other site
395491001169	ABC-ATPase subunit interface; other site
395491001170	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
395491001171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001172	conserved gate region; other site
395491001173	dimer interface [polypeptide binding]; other site
395491001174	putative PBP binding loops; other site
395491001175	ABC-ATPase subunit interface; other site
395491001176	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491001177	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491001178	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491001179	Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262
395491001180	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
395491001181	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
395491001182	Cupin domain; Region: Cupin_2; pfam07883
395491001183	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
395491001184	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
395491001185	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
395491001186	active site
395491001187	intracellular protease, PfpI family; Region: PfpI; TIGR01382
395491001188	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
395491001189	conserved cys residue [active]
395491001190	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491001191	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491001192	DNA-binding site [nucleotide binding]; DNA binding site
395491001193	FCD domain; Region: FCD; pfam07729
395491001194	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
395491001195	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
395491001196	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
395491001197	active site
395491001198	NAD binding site [chemical binding]; other site
395491001199	metal binding site [ion binding]; metal-binding site
395491001200	succinic semialdehyde dehydrogenase; Region: PLN02278
395491001201	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
395491001202	tetramerization interface [polypeptide binding]; other site
395491001203	NAD(P) binding site [chemical binding]; other site
395491001204	catalytic residues [active]
395491001205	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
395491001206	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
395491001207	nucleophilic elbow; other site
395491001208	catalytic triad; other site
395491001209	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491001210	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
395491001211	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491001212	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491001213	putative DNA binding site [nucleotide binding]; other site
395491001214	putative Zn2+ binding site [ion binding]; other site
395491001215	AsnC family; Region: AsnC_trans_reg; pfam01037
395491001216	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395491001217	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491001218	Walker A/P-loop; other site
395491001219	ATP binding site [chemical binding]; other site
395491001220	Q-loop/lid; other site
395491001221	ABC transporter signature motif; other site
395491001222	Walker B; other site
395491001223	D-loop; other site
395491001224	H-loop/switch region; other site
395491001225	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491001226	Walker A/P-loop; other site
395491001227	ATP binding site [chemical binding]; other site
395491001228	Q-loop/lid; other site
395491001229	ABC transporter signature motif; other site
395491001230	Walker B; other site
395491001231	D-loop; other site
395491001232	H-loop/switch region; other site
395491001233	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491001234	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491001235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001236	dimer interface [polypeptide binding]; other site
395491001237	ABC-ATPase subunit interface; other site
395491001238	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491001239	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001240	dimer interface [polypeptide binding]; other site
395491001241	conserved gate region; other site
395491001242	putative PBP binding loops; other site
395491001243	ABC-ATPase subunit interface; other site
395491001244	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491001245	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
395491001246	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
395491001247	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
395491001248	hypothetical protein; Provisional; Region: PRK05965
395491001249	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395491001250	inhibitor-cofactor binding pocket; inhibition site
395491001251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491001252	catalytic residue [active]
395491001253	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491001254	Coenzyme A binding pocket [chemical binding]; other site
395491001255	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
395491001256	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
395491001257	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
395491001258	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395491001259	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491001260	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491001261	DNA binding site [nucleotide binding]
395491001262	domain linker motif; other site
395491001263	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
395491001264	putative dimerization interface [polypeptide binding]; other site
395491001265	putative ligand binding site [chemical binding]; other site
395491001266	putative aldolase; Validated; Region: PRK08130
395491001267	intersubunit interface [polypeptide binding]; other site
395491001268	active site
395491001269	Zn2+ binding site [ion binding]; other site
395491001270	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
395491001271	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
395491001272	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
395491001273	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491001274	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491001275	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
395491001276	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
395491001277	ATP binding site [chemical binding]; other site
395491001278	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
395491001279	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
395491001280	active site
395491001281	TPR repeat; Region: TPR_11; pfam13414
395491001282	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491001283	TPR motif; other site
395491001284	binding surface
395491001285	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491001286	TPR motif; other site
395491001287	binding surface
395491001288	succinic semialdehyde dehydrogenase; Region: PLN02278
395491001289	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
395491001290	tetramerization interface [polypeptide binding]; other site
395491001291	NAD(P) binding site [chemical binding]; other site
395491001292	catalytic residues [active]
395491001293	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
395491001294	tartrate dehydrogenase; Region: TTC; TIGR02089
395491001295	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
395491001296	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395491001297	NAD(P) binding site [chemical binding]; other site
395491001298	catalytic residues [active]
395491001299	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
395491001300	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
395491001301	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
395491001302	putative ligand binding site [chemical binding]; other site
395491001303	NAD binding site [chemical binding]; other site
395491001304	dimerization interface [polypeptide binding]; other site
395491001305	catalytic site [active]
395491001306	acetylornithine deacetylase; Provisional; Region: PRK07522
395491001307	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
395491001308	metal binding site [ion binding]; metal-binding site
395491001309	putative dimer interface [polypeptide binding]; other site
395491001310	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
395491001311	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
395491001312	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
395491001313	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491001314	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491001315	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491001316	dimerization interface [polypeptide binding]; other site
395491001317	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
395491001318	HPP family; Region: HPP; pfam04982
395491001319	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395491001320	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
395491001321	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
395491001322	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
395491001323	ring oligomerisation interface [polypeptide binding]; other site
395491001324	ATP/Mg binding site [chemical binding]; other site
395491001325	stacking interactions; other site
395491001326	hinge regions; other site
395491001327	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
395491001328	oligomerisation interface [polypeptide binding]; other site
395491001329	mobile loop; other site
395491001330	roof hairpin; other site
395491001331	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
395491001332	HD domain; Region: HD_4; pfam13328
395491001333	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
395491001334	nucleotide binding site/active site [active]
395491001335	HIT family signature motif; other site
395491001336	catalytic residue [active]
395491001337	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752
395491001338	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491001339	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491001340	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395491001341	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491001342	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491001343	Walker A/P-loop; other site
395491001344	ATP binding site [chemical binding]; other site
395491001345	Q-loop/lid; other site
395491001346	ABC transporter signature motif; other site
395491001347	Walker B; other site
395491001348	D-loop; other site
395491001349	H-loop/switch region; other site
395491001350	TOBE domain; Region: TOBE; pfam03459
395491001351	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
395491001352	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
395491001353	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491001354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001355	dimer interface [polypeptide binding]; other site
395491001356	conserved gate region; other site
395491001357	putative PBP binding loops; other site
395491001358	ABC-ATPase subunit interface; other site
395491001359	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
395491001360	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001361	dimer interface [polypeptide binding]; other site
395491001362	conserved gate region; other site
395491001363	putative PBP binding loops; other site
395491001364	ABC-ATPase subunit interface; other site
395491001365	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
395491001366	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
395491001367	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
395491001368	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
395491001369	conserved cys residue [active]
395491001370	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491001371	Helix-turn-helix domain; Region: HTH_18; pfam12833
395491001372	Isochorismatase family; Region: Isochorismatase; pfam00857
395491001373	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
395491001374	catalytic triad [active]
395491001375	conserved cis-peptide bond; other site
395491001376	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
395491001377	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491001378	active site
395491001379	phosphorylation site [posttranslational modification]
395491001380	intermolecular recognition site; other site
395491001381	dimerization interface [polypeptide binding]; other site
395491001382	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491001383	DNA binding site [nucleotide binding]
395491001384	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
395491001385	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491001386	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491001387	dimer interface [polypeptide binding]; other site
395491001388	phosphorylation site [posttranslational modification]
395491001389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491001390	ATP binding site [chemical binding]; other site
395491001391	Mg2+ binding site [ion binding]; other site
395491001392	G-X-G motif; other site
395491001393	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491001394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001395	dimer interface [polypeptide binding]; other site
395491001396	conserved gate region; other site
395491001397	putative PBP binding loops; other site
395491001398	ABC-ATPase subunit interface; other site
395491001399	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395491001400	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395491001401	Walker A/P-loop; other site
395491001402	ATP binding site [chemical binding]; other site
395491001403	Q-loop/lid; other site
395491001404	ABC transporter signature motif; other site
395491001405	Walker B; other site
395491001406	D-loop; other site
395491001407	H-loop/switch region; other site
395491001408	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395491001409	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395491001410	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491001411	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491001412	DNA-binding site [nucleotide binding]; DNA binding site
395491001413	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
395491001414	Predicted transcriptional regulator [Transcription]; Region: COG3905
395491001415	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
395491001416	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491001417	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491001418	ligand binding site [chemical binding]; other site
395491001419	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
395491001420	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491001421	putative ligand binding site [chemical binding]; other site
395491001422	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491001423	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491001424	dimer interface [polypeptide binding]; other site
395491001425	putative CheW interface [polypeptide binding]; other site
395491001426	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
395491001427	benzoate transport; Region: 2A0115; TIGR00895
395491001428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491001429	putative substrate translocation pore; other site
395491001430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491001431	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395491001432	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
395491001433	salicylate hydroxylase; Provisional; Region: PRK08163
395491001434	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491001435	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
395491001436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491001437	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
395491001438	putative dimerization interface [polypeptide binding]; other site
395491001439	putative substrate binding pocket [chemical binding]; other site
395491001440	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491001441	putative substrate translocation pore; other site
395491001442	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491001443	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491001444	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
395491001445	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
395491001446	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
395491001447	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491001448	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491001449	Walker A/P-loop; other site
395491001450	ATP binding site [chemical binding]; other site
395491001451	Q-loop/lid; other site
395491001452	ABC transporter signature motif; other site
395491001453	Walker B; other site
395491001454	D-loop; other site
395491001455	H-loop/switch region; other site
395491001456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001457	dimer interface [polypeptide binding]; other site
395491001458	conserved gate region; other site
395491001459	putative PBP binding loops; other site
395491001460	ABC-ATPase subunit interface; other site
395491001461	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491001462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001463	dimer interface [polypeptide binding]; other site
395491001464	conserved gate region; other site
395491001465	putative PBP binding loops; other site
395491001466	ABC-ATPase subunit interface; other site
395491001467	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395491001468	MarR family; Region: MarR_2; cl17246
395491001469	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491001470	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395491001471	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491001472	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491001473	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491001474	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491001475	DNA binding site [nucleotide binding]
395491001476	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491001477	ligand binding site [chemical binding]; other site
395491001478	dimerization interface [polypeptide binding]; other site
395491001479	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491001480	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491001481	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395491001482	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491001483	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491001484	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395491001485	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491001486	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491001487	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395491001488	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
395491001489	Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953
395491001490	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
395491001491	Na binding site [ion binding]; other site
395491001492	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
395491001493	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491001494	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491001495	dimer interface [polypeptide binding]; other site
395491001496	putative CheW interface [polypeptide binding]; other site
395491001497	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
395491001498	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
395491001499	oligomer interface [polypeptide binding]; other site
395491001500	metal binding site [ion binding]; metal-binding site
395491001501	metal binding site [ion binding]; metal-binding site
395491001502	putative Cl binding site [ion binding]; other site
395491001503	basic sphincter; other site
395491001504	hydrophobic gate; other site
395491001505	periplasmic entrance; other site
395491001506	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395491001507	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
395491001508	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
395491001509	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
395491001510	active site
395491001511	homodimer interface [polypeptide binding]; other site
395491001512	catalytic site [active]
395491001513	acceptor binding site [chemical binding]; other site
395491001514	trehalose synthase; Region: treS_nterm; TIGR02456
395491001515	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
395491001516	active site
395491001517	catalytic site [active]
395491001518	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
395491001519	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
395491001520	glycogen branching enzyme; Provisional; Region: PRK05402
395491001521	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
395491001522	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
395491001523	active site
395491001524	catalytic site [active]
395491001525	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
395491001526	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
395491001527	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
395491001528	Walker A/P-loop; other site
395491001529	ATP binding site [chemical binding]; other site
395491001530	Q-loop/lid; other site
395491001531	ABC transporter signature motif; other site
395491001532	Walker B; other site
395491001533	D-loop; other site
395491001534	H-loop/switch region; other site
395491001535	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
395491001536	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491001537	ABC-ATPase subunit  interface; other site
395491001538	dimer interface [polypeptide binding]; other site
395491001539	putative PBP binding regions; other site
395491001540	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
395491001541	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
395491001542	intersubunit interface [polypeptide binding]; other site
395491001543	Helix-turn-helix domain; Region: HTH_17; cl17695
395491001544	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491001545	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
395491001546	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395491001547	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001548	dimerization interface [polypeptide binding]; other site
395491001549	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001550	dimerization interface [polypeptide binding]; other site
395491001551	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001552	dimerization interface [polypeptide binding]; other site
395491001553	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001554	dimerization interface [polypeptide binding]; other site
395491001555	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395491001556	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001557	dimerization interface [polypeptide binding]; other site
395491001558	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001559	dimerization interface [polypeptide binding]; other site
395491001560	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001561	dimerization interface [polypeptide binding]; other site
395491001562	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395491001563	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001564	dimerization interface [polypeptide binding]; other site
395491001565	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001566	dimerization interface [polypeptide binding]; other site
395491001567	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001568	dimerization interface [polypeptide binding]; other site
395491001569	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001570	dimerization interface [polypeptide binding]; other site
395491001571	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395491001572	GAF domain; Region: GAF; pfam01590
395491001573	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491001574	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491001575	dimer interface [polypeptide binding]; other site
395491001576	phosphorylation site [posttranslational modification]
395491001577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491001578	ATP binding site [chemical binding]; other site
395491001579	Mg2+ binding site [ion binding]; other site
395491001580	G-X-G motif; other site
395491001581	Response regulator receiver domain; Region: Response_reg; pfam00072
395491001582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491001583	active site
395491001584	phosphorylation site [posttranslational modification]
395491001585	intermolecular recognition site; other site
395491001586	dimerization interface [polypeptide binding]; other site
395491001587	Response regulator receiver domain; Region: Response_reg; pfam00072
395491001588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491001589	active site
395491001590	phosphorylation site [posttranslational modification]
395491001591	intermolecular recognition site; other site
395491001592	dimerization interface [polypeptide binding]; other site
395491001593	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491001594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491001595	active site
395491001596	phosphorylation site [posttranslational modification]
395491001597	intermolecular recognition site; other site
395491001598	dimerization interface [polypeptide binding]; other site
395491001599	Response regulator receiver domain; Region: Response_reg; pfam00072
395491001600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491001601	active site
395491001602	phosphorylation site [posttranslational modification]
395491001603	intermolecular recognition site; other site
395491001604	dimerization interface [polypeptide binding]; other site
395491001605	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491001606	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491001607	dimer interface [polypeptide binding]; other site
395491001608	phosphorylation site [posttranslational modification]
395491001609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491001610	ATP binding site [chemical binding]; other site
395491001611	Mg2+ binding site [ion binding]; other site
395491001612	G-X-G motif; other site
395491001613	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491001614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491001615	active site
395491001616	phosphorylation site [posttranslational modification]
395491001617	intermolecular recognition site; other site
395491001618	dimerization interface [polypeptide binding]; other site
395491001619	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
395491001620	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
395491001621	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
395491001622	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
395491001623	catalytic site [active]
395491001624	active site
395491001625	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
395491001626	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
395491001627	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491001628	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491001629	DNA binding site [nucleotide binding]
395491001630	domain linker motif; other site
395491001631	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491001632	dimerization interface [polypeptide binding]; other site
395491001633	ligand binding site [chemical binding]; other site
395491001634	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491001635	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491001636	substrate binding pocket [chemical binding]; other site
395491001637	membrane-bound complex binding site; other site
395491001638	hinge residues; other site
395491001639	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491001640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001641	dimer interface [polypeptide binding]; other site
395491001642	conserved gate region; other site
395491001643	putative PBP binding loops; other site
395491001644	ABC-ATPase subunit interface; other site
395491001645	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395491001646	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491001647	Walker A/P-loop; other site
395491001648	ATP binding site [chemical binding]; other site
395491001649	Q-loop/lid; other site
395491001650	ABC transporter signature motif; other site
395491001651	Walker B; other site
395491001652	D-loop; other site
395491001653	H-loop/switch region; other site
395491001654	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491001655	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
395491001656	putative catalytic site [active]
395491001657	putative metal binding site [ion binding]; other site
395491001658	putative phosphate binding site [ion binding]; other site
395491001659	Predicted integral membrane protein [Function unknown]; Region: COG0392
395491001660	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
395491001661	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
395491001662	putative active site [active]
395491001663	catalytic site [active]
395491001664	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
395491001665	putative active site [active]
395491001666	catalytic site [active]
395491001667	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
395491001668	putative active site [active]
395491001669	Uncharacterized conserved protein [Function unknown]; Region: COG1415
395491001670	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
395491001671	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
395491001672	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395491001673	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395491001674	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
395491001675	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
395491001676	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491001677	motif II; other site
395491001678	Uncharacterized conserved protein [Function unknown]; Region: COG1262
395491001679	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395491001680	Oxygen tolerance; Region: BatD; pfam13584
395491001681	von Willebrand factor type A domain; Region: VWA_2; pfam13519
395491001682	metal ion-dependent adhesion site (MIDAS); other site
395491001683	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491001684	binding surface
395491001685	TPR motif; other site
395491001686	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395491001687	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
395491001688	metal ion-dependent adhesion site (MIDAS); other site
395491001689	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
395491001690	Protein of unknown function DUF58; Region: DUF58; pfam01882
395491001691	MoxR-like ATPases [General function prediction only]; Region: COG0714
395491001692	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491001693	Walker A motif; other site
395491001694	ATP binding site [chemical binding]; other site
395491001695	Walker B motif; other site
395491001696	arginine finger; other site
395491001697	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395491001698	Sulfatase; Region: Sulfatase; pfam00884
395491001699	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
395491001700	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
395491001701	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395491001702	binding surface
395491001703	TPR motif; other site
395491001704	Uncharacterized conserved protein [Function unknown]; Region: COG5361
395491001705	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
395491001706	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
395491001707	EamA-like transporter family; Region: EamA; pfam00892
395491001708	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
395491001709	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491001710	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
395491001711	putative dimerization interface [polypeptide binding]; other site
395491001712	Predicted membrane protein [Function unknown]; Region: COG2855
395491001713	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491001714	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
395491001715	ligand binding site [chemical binding]; other site
395491001716	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491001717	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491001718	Walker A/P-loop; other site
395491001719	ATP binding site [chemical binding]; other site
395491001720	Q-loop/lid; other site
395491001721	ABC transporter signature motif; other site
395491001722	Walker B; other site
395491001723	D-loop; other site
395491001724	H-loop/switch region; other site
395491001725	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491001726	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491001727	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491001728	TM-ABC transporter signature motif; other site
395491001729	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
395491001730	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491001731	DNA binding residues [nucleotide binding]
395491001732	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
395491001733	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491001734	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491001735	active site
395491001736	catalytic tetrad [active]
395491001737	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
395491001738	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395491001739	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
395491001740	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
395491001741	putative active site; other site
395491001742	catalytic residue [active]
395491001743	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
395491001744	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
395491001745	putative N- and C-terminal domain interface [polypeptide binding]; other site
395491001746	putative active site [active]
395491001747	MgATP binding site [chemical binding]; other site
395491001748	catalytic site [active]
395491001749	metal binding site [ion binding]; metal-binding site
395491001750	putative xylulose binding site [chemical binding]; other site
395491001751	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
395491001752	lycopene cyclase; Region: lycopene_cycl; TIGR01789
395491001753	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395491001754	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395491001755	DNA-binding site [nucleotide binding]; DNA binding site
395491001756	RNA-binding motif; other site
395491001757	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491001758	dimerization interface [polypeptide binding]; other site
395491001759	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491001760	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491001761	dimer interface [polypeptide binding]; other site
395491001762	putative CheW interface [polypeptide binding]; other site
395491001763	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491001764	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491001765	TAP-like protein; Region: Abhydrolase_4; pfam08386
395491001766	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491001767	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491001768	Walker A/P-loop; other site
395491001769	ATP binding site [chemical binding]; other site
395491001770	Q-loop/lid; other site
395491001771	ABC transporter signature motif; other site
395491001772	Walker B; other site
395491001773	D-loop; other site
395491001774	H-loop/switch region; other site
395491001775	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491001776	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491001777	Walker A/P-loop; other site
395491001778	ATP binding site [chemical binding]; other site
395491001779	Q-loop/lid; other site
395491001780	ABC transporter signature motif; other site
395491001781	Walker B; other site
395491001782	D-loop; other site
395491001783	H-loop/switch region; other site
395491001784	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491001785	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
395491001786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001787	dimer interface [polypeptide binding]; other site
395491001788	conserved gate region; other site
395491001789	putative PBP binding loops; other site
395491001790	ABC-ATPase subunit interface; other site
395491001791	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491001792	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001793	dimer interface [polypeptide binding]; other site
395491001794	conserved gate region; other site
395491001795	putative PBP binding loops; other site
395491001796	ABC-ATPase subunit interface; other site
395491001797	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
395491001798	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
395491001799	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491001800	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
395491001801	inhibitor site; inhibition site
395491001802	active site
395491001803	dimer interface [polypeptide binding]; other site
395491001804	catalytic residue [active]
395491001805	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
395491001806	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
395491001807	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491001808	NAD(P) binding site [chemical binding]; other site
395491001809	active site
395491001810	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491001811	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491001812	DNA-binding site [nucleotide binding]; DNA binding site
395491001813	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
395491001814	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491001815	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
395491001816	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491001817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001818	dimer interface [polypeptide binding]; other site
395491001819	conserved gate region; other site
395491001820	putative PBP binding loops; other site
395491001821	ABC-ATPase subunit interface; other site
395491001822	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491001823	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001824	dimer interface [polypeptide binding]; other site
395491001825	conserved gate region; other site
395491001826	putative PBP binding loops; other site
395491001827	ABC-ATPase subunit interface; other site
395491001828	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395491001829	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491001830	Walker A/P-loop; other site
395491001831	ATP binding site [chemical binding]; other site
395491001832	Q-loop/lid; other site
395491001833	ABC transporter signature motif; other site
395491001834	Walker B; other site
395491001835	D-loop; other site
395491001836	H-loop/switch region; other site
395491001837	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491001838	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491001839	Walker A/P-loop; other site
395491001840	ATP binding site [chemical binding]; other site
395491001841	Q-loop/lid; other site
395491001842	ABC transporter signature motif; other site
395491001843	Walker B; other site
395491001844	D-loop; other site
395491001845	H-loop/switch region; other site
395491001846	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491001847	galactonate dehydratase; Provisional; Region: PRK14017
395491001848	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
395491001849	active site pocket [active]
395491001850	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
395491001851	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
395491001852	active site pocket [active]
395491001853	Predicted flavoprotein [General function prediction only]; Region: COG0431
395491001854	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491001855	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
395491001856	putative FMN binding site [chemical binding]; other site
395491001857	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491001858	dimerization interface [polypeptide binding]; other site
395491001859	putative DNA binding site [nucleotide binding]; other site
395491001860	putative Zn2+ binding site [ion binding]; other site
395491001861	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
395491001862	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491001863	active site
395491001864	phosphorylation site [posttranslational modification]
395491001865	intermolecular recognition site; other site
395491001866	dimerization interface [polypeptide binding]; other site
395491001867	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491001868	DNA binding residues [nucleotide binding]
395491001869	dimerization interface [polypeptide binding]; other site
395491001870	Response regulator receiver domain; Region: Response_reg; pfam00072
395491001871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491001872	active site
395491001873	phosphorylation site [posttranslational modification]
395491001874	intermolecular recognition site; other site
395491001875	dimerization interface [polypeptide binding]; other site
395491001876	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
395491001877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491001878	active site
395491001879	phosphorylation site [posttranslational modification]
395491001880	intermolecular recognition site; other site
395491001881	dimerization interface [polypeptide binding]; other site
395491001882	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491001883	DNA binding residues [nucleotide binding]
395491001884	dimerization interface [polypeptide binding]; other site
395491001885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491001886	putative substrate translocation pore; other site
395491001887	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491001888	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491001889	putative active site [active]
395491001890	heme pocket [chemical binding]; other site
395491001891	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491001892	putative active site [active]
395491001893	heme pocket [chemical binding]; other site
395491001894	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491001895	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491001896	putative active site [active]
395491001897	heme pocket [chemical binding]; other site
395491001898	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491001899	putative active site [active]
395491001900	heme pocket [chemical binding]; other site
395491001901	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491001902	PAS fold; Region: PAS_3; pfam08447
395491001903	putative active site [active]
395491001904	heme pocket [chemical binding]; other site
395491001905	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491001906	dimer interface [polypeptide binding]; other site
395491001907	phosphorylation site [posttranslational modification]
395491001908	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491001909	ATP binding site [chemical binding]; other site
395491001910	Mg2+ binding site [ion binding]; other site
395491001911	G-X-G motif; other site
395491001912	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
395491001913	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491001914	NAD(P) binding site [chemical binding]; other site
395491001915	active site
395491001916	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
395491001917	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491001918	P-loop; other site
395491001919	Magnesium ion binding site [ion binding]; other site
395491001920	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491001921	Magnesium ion binding site [ion binding]; other site
395491001922	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
395491001923	ParB-like nuclease domain; Region: ParBc; pfam02195
395491001924	replication initiation protein RepC; Provisional; Region: PRK13824
395491001925	Replication protein C N-terminal domain; Region: RP-C; pfam03428
395491001926	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
395491001927	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491001928	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
395491001929	inhibitor site; inhibition site
395491001930	active site
395491001931	dimer interface [polypeptide binding]; other site
395491001932	catalytic residue [active]
395491001933	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491001934	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
395491001935	DNA-binding site [nucleotide binding]; DNA binding site
395491001936	FCD domain; Region: FCD; pfam07729
395491001937	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491001938	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491001939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001940	dimer interface [polypeptide binding]; other site
395491001941	conserved gate region; other site
395491001942	putative PBP binding loops; other site
395491001943	ABC-ATPase subunit interface; other site
395491001944	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491001945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001946	putative PBP binding loops; other site
395491001947	ABC-ATPase subunit interface; other site
395491001948	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491001949	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
395491001950	substrate binding site [chemical binding]; other site
395491001951	ATP binding site [chemical binding]; other site
395491001952	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
395491001953	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
395491001954	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395491001955	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491001956	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
395491001957	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001958	dimer interface [polypeptide binding]; other site
395491001959	conserved gate region; other site
395491001960	putative PBP binding loops; other site
395491001961	ABC-ATPase subunit interface; other site
395491001962	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491001963	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001964	dimer interface [polypeptide binding]; other site
395491001965	conserved gate region; other site
395491001966	putative PBP binding loops; other site
395491001967	ABC-ATPase subunit interface; other site
395491001968	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491001969	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491001970	Walker A/P-loop; other site
395491001971	ATP binding site [chemical binding]; other site
395491001972	Q-loop/lid; other site
395491001973	ABC transporter signature motif; other site
395491001974	Walker B; other site
395491001975	D-loop; other site
395491001976	H-loop/switch region; other site
395491001977	TOBE domain; Region: TOBE_2; pfam08402
395491001978	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
395491001979	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
395491001980	putative active site [active]
395491001981	catalytic site [active]
395491001982	putative metal binding site [ion binding]; other site
395491001983	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
395491001984	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
395491001985	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
395491001986	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
395491001987	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
395491001988	active site
395491001989	motif I; other site
395491001990	motif II; other site
395491001991	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
395491001992	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491001993	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001994	dimer interface [polypeptide binding]; other site
395491001995	conserved gate region; other site
395491001996	putative PBP binding loops; other site
395491001997	ABC-ATPase subunit interface; other site
395491001998	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491001999	dimer interface [polypeptide binding]; other site
395491002000	conserved gate region; other site
395491002001	putative PBP binding loops; other site
395491002002	ABC-ATPase subunit interface; other site
395491002003	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491002004	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491002005	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491002006	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491002007	DNA binding site [nucleotide binding]
395491002008	domain linker motif; other site
395491002009	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491002010	dimerization interface [polypeptide binding]; other site
395491002011	ligand binding site [chemical binding]; other site
395491002012	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
395491002013	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395491002014	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491002015	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491002016	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491002017	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
395491002018	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
395491002019	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
395491002020	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
395491002021	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
395491002022	putative active site; other site
395491002023	catalytic residue [active]
395491002024	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
395491002025	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491002026	substrate binding site [chemical binding]; other site
395491002027	ATP binding site [chemical binding]; other site
395491002028	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491002029	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491002030	Walker A/P-loop; other site
395491002031	ATP binding site [chemical binding]; other site
395491002032	Q-loop/lid; other site
395491002033	ABC transporter signature motif; other site
395491002034	Walker B; other site
395491002035	D-loop; other site
395491002036	H-loop/switch region; other site
395491002037	TOBE domain; Region: TOBE_2; pfam08402
395491002038	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491002039	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491002040	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491002041	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
395491002042	Metal-binding active site; metal-binding site
395491002043	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491002044	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
395491002045	catalytic site [active]
395491002046	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
395491002047	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
395491002048	substrate binding site [chemical binding]; other site
395491002049	hexamer interface [polypeptide binding]; other site
395491002050	metal binding site [ion binding]; metal-binding site
395491002051	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491002052	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395491002053	nucleotide binding site [chemical binding]; other site
395491002054	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491002055	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491002056	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491002057	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
395491002058	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
395491002059	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395491002060	putative NAD(P) binding site [chemical binding]; other site
395491002061	hypothetical protein; Provisional; Region: PRK07482
395491002062	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395491002063	inhibitor-cofactor binding pocket; inhibition site
395491002064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491002065	catalytic residue [active]
395491002066	succinic semialdehyde dehydrogenase; Region: PLN02278
395491002067	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
395491002068	tetramerization interface [polypeptide binding]; other site
395491002069	NAD(P) binding site [chemical binding]; other site
395491002070	catalytic residues [active]
395491002071	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491002072	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491002073	putative DNA binding site [nucleotide binding]; other site
395491002074	putative Zn2+ binding site [ion binding]; other site
395491002075	AsnC family; Region: AsnC_trans_reg; pfam01037
395491002076	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
395491002077	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491002078	DNA-binding site [nucleotide binding]; DNA binding site
395491002079	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491002080	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491002081	homodimer interface [polypeptide binding]; other site
395491002082	catalytic residue [active]
395491002083	ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005
395491002084	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491002085	Walker A/P-loop; other site
395491002086	ATP binding site [chemical binding]; other site
395491002087	Q-loop/lid; other site
395491002088	ABC transporter signature motif; other site
395491002089	Walker B; other site
395491002090	D-loop; other site
395491002091	H-loop/switch region; other site
395491002092	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
395491002093	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491002094	substrate binding pocket [chemical binding]; other site
395491002095	membrane-bound complex binding site; other site
395491002096	hinge residues; other site
395491002097	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491002098	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002099	dimer interface [polypeptide binding]; other site
395491002100	conserved gate region; other site
395491002101	putative PBP binding loops; other site
395491002102	ABC-ATPase subunit interface; other site
395491002103	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491002104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002105	dimer interface [polypeptide binding]; other site
395491002106	conserved gate region; other site
395491002107	putative PBP binding loops; other site
395491002108	ABC-ATPase subunit interface; other site
395491002109	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
395491002110	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
395491002111	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
395491002112	tetramer interface [polypeptide binding]; other site
395491002113	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491002114	catalytic residue [active]
395491002115	ectoine utilization protein EutC; Validated; Region: PRK08291
395491002116	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
395491002117	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
395491002118	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
395491002119	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
395491002120	active site
395491002121	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
395491002122	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
395491002123	putative active site [active]
395491002124	Zn binding site [ion binding]; other site
395491002125	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491002126	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491002127	dimer interface [polypeptide binding]; other site
395491002128	putative CheW interface [polypeptide binding]; other site
395491002129	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
395491002130	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395491002131	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395491002132	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
395491002133	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
395491002134	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
395491002135	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
395491002136	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
395491002137	EF-hand domain pair; Region: EF_hand_5; pfam13499
395491002138	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
395491002139	Ca2+ binding site [ion binding]; other site
395491002140	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491002141	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491002142	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491002143	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491002144	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491002145	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491002146	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491002147	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491002148	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491002149	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491002150	putative active site [active]
395491002151	heme pocket [chemical binding]; other site
395491002152	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491002153	putative active site [active]
395491002154	heme pocket [chemical binding]; other site
395491002155	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491002156	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491002157	dimer interface [polypeptide binding]; other site
395491002158	putative CheW interface [polypeptide binding]; other site
395491002159	enoyl-CoA hydratase; Provisional; Region: PRK05980
395491002160	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395491002161	substrate binding site [chemical binding]; other site
395491002162	oxyanion hole (OAH) forming residues; other site
395491002163	trimer interface [polypeptide binding]; other site
395491002164	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491002165	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491002166	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491002167	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491002168	substrate binding pocket [chemical binding]; other site
395491002169	membrane-bound complex binding site; other site
395491002170	hinge residues; other site
395491002171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002172	dimer interface [polypeptide binding]; other site
395491002173	conserved gate region; other site
395491002174	putative PBP binding loops; other site
395491002175	ABC-ATPase subunit interface; other site
395491002176	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002177	putative PBP binding loops; other site
395491002178	dimer interface [polypeptide binding]; other site
395491002179	ABC-ATPase subunit interface; other site
395491002180	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395491002181	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491002182	Walker A/P-loop; other site
395491002183	ATP binding site [chemical binding]; other site
395491002184	Q-loop/lid; other site
395491002185	ABC transporter signature motif; other site
395491002186	Walker B; other site
395491002187	D-loop; other site
395491002188	H-loop/switch region; other site
395491002189	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
395491002190	oligomeric interface; other site
395491002191	putative active site [active]
395491002192	homodimer interface [polypeptide binding]; other site
395491002193	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
395491002194	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491002195	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491002196	substrate binding pocket [chemical binding]; other site
395491002197	membrane-bound complex binding site; other site
395491002198	hinge residues; other site
395491002199	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002200	dimer interface [polypeptide binding]; other site
395491002201	conserved gate region; other site
395491002202	putative PBP binding loops; other site
395491002203	ABC-ATPase subunit interface; other site
395491002204	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002205	dimer interface [polypeptide binding]; other site
395491002206	conserved gate region; other site
395491002207	putative PBP binding loops; other site
395491002208	ABC-ATPase subunit interface; other site
395491002209	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395491002210	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491002211	Walker A/P-loop; other site
395491002212	ATP binding site [chemical binding]; other site
395491002213	Q-loop/lid; other site
395491002214	ABC transporter signature motif; other site
395491002215	Walker B; other site
395491002216	D-loop; other site
395491002217	H-loop/switch region; other site
395491002218	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
395491002219	Uncharacterized conserved protein [Function unknown]; Region: COG5654
395491002220	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
395491002221	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
395491002222	PspA/IM30 family; Region: PspA_IM30; pfam04012
395491002223	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938
395491002224	Ion channel; Region: Ion_trans_2; pfam07885
395491002225	TrkA-N domain; Region: TrkA_N; pfam02254
395491002226	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
395491002227	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
395491002228	Protein of unknown function (DUF1190); Region: DUF1190; pfam06693
395491002229	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
395491002230	Winged helix-turn helix; Region: HTH_29; pfam13551
395491002231	Homeodomain-like domain; Region: HTH_32; pfam13565
395491002232	Integrase core domain; Region: rve; pfam00665
395491002233	Helix-turn-helix domain; Region: HTH_28; pfam13518
395491002234	Winged helix-turn helix; Region: HTH_29; pfam13551
395491002235	Homeodomain-like domain; Region: HTH_32; pfam13565
395491002236	Integrase core domain; Region: rve; pfam00665
395491002237	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
395491002238	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
395491002239	putative active site pocket [active]
395491002240	metal binding site [ion binding]; metal-binding site
395491002241	cell density-dependent motility repressor; Provisional; Region: PRK10082
395491002242	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491002243	LysR substrate binding domain; Region: LysR_substrate; pfam03466
395491002244	dimerization interface [polypeptide binding]; other site
395491002245	Predicted transcriptional regulators [Transcription]; Region: COG1733
395491002246	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395491002247	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
395491002248	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
395491002249	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491002250	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491002251	DNA binding site [nucleotide binding]
395491002252	domain linker motif; other site
395491002253	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
395491002254	putative ligand binding site [chemical binding]; other site
395491002255	putative dimerization interface [polypeptide binding]; other site
395491002256	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491002257	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491002258	TM-ABC transporter signature motif; other site
395491002259	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491002260	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
395491002261	Walker A/P-loop; other site
395491002262	ATP binding site [chemical binding]; other site
395491002263	Q-loop/lid; other site
395491002264	ABC transporter signature motif; other site
395491002265	Walker B; other site
395491002266	D-loop; other site
395491002267	H-loop/switch region; other site
395491002268	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
395491002269	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491002270	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491002271	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491002272	Helix-turn-helix domain; Region: HTH_36; pfam13730
395491002273	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
395491002274	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
395491002275	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491002276	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491002277	putative substrate translocation pore; other site
395491002278	ribosome small subunit-dependent GTPase A; Region: TIGR00157
395491002279	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
395491002280	GTPase/Zn-binding domain interface [polypeptide binding]; other site
395491002281	GTP/Mg2+ binding site [chemical binding]; other site
395491002282	G4 box; other site
395491002283	G5 box; other site
395491002284	G1 box; other site
395491002285	Switch I region; other site
395491002286	G2 box; other site
395491002287	G3 box; other site
395491002288	Switch II region; other site
395491002289	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491002290	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
395491002291	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
395491002292	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395491002293	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
395491002294	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491002295	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491002296	DNA binding site [nucleotide binding]
395491002297	domain linker motif; other site
395491002298	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
395491002299	dimerization interface [polypeptide binding]; other site
395491002300	ligand binding site [chemical binding]; other site
395491002301	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
395491002302	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491002303	ligand binding site [chemical binding]; other site
395491002304	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491002305	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491002306	Walker A/P-loop; other site
395491002307	ATP binding site [chemical binding]; other site
395491002308	Q-loop/lid; other site
395491002309	ABC transporter signature motif; other site
395491002310	Walker B; other site
395491002311	D-loop; other site
395491002312	H-loop/switch region; other site
395491002313	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491002314	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491002315	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491002316	TM-ABC transporter signature motif; other site
395491002317	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491002318	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491002319	TM-ABC transporter signature motif; other site
395491002320	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491002321	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
395491002322	DNA interaction; other site
395491002323	Metal-binding active site; metal-binding site
395491002324	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
395491002325	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
395491002326	intersubunit interface [polypeptide binding]; other site
395491002327	active site
395491002328	zinc binding site [ion binding]; other site
395491002329	Na+ binding site [ion binding]; other site
395491002330	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
395491002331	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
395491002332	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
395491002333	putative N- and C-terminal domain interface [polypeptide binding]; other site
395491002334	putative active site [active]
395491002335	MgATP binding site [chemical binding]; other site
395491002336	catalytic site [active]
395491002337	metal binding site [ion binding]; metal-binding site
395491002338	putative xylulose binding site [chemical binding]; other site
395491002339	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
395491002340	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
395491002341	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
395491002342	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
395491002343	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491002344	ligand binding site [chemical binding]; other site
395491002345	dimerization interface [polypeptide binding]; other site
395491002346	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491002347	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491002348	TM-ABC transporter signature motif; other site
395491002349	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491002350	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491002351	Walker A/P-loop; other site
395491002352	ATP binding site [chemical binding]; other site
395491002353	Q-loop/lid; other site
395491002354	ABC transporter signature motif; other site
395491002355	Walker B; other site
395491002356	D-loop; other site
395491002357	H-loop/switch region; other site
395491002358	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491002359	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054
395491002360	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
395491002361	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
395491002362	putative N- and C-terminal domain interface [polypeptide binding]; other site
395491002363	putative active site [active]
395491002364	MgATP binding site [chemical binding]; other site
395491002365	catalytic site [active]
395491002366	metal binding site [ion binding]; metal-binding site
395491002367	putative xylulose binding site [chemical binding]; other site
395491002368	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
395491002369	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
395491002370	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
395491002371	PCI domain; Region: PCI; cl02111
395491002372	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
395491002373	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
395491002374	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
395491002375	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
395491002376	triosephosphate isomerase; Provisional; Region: PRK14565
395491002377	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
395491002378	substrate binding site [chemical binding]; other site
395491002379	dimer interface [polypeptide binding]; other site
395491002380	catalytic triad [active]
395491002381	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
395491002382	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
395491002383	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
395491002384	active site
395491002385	DNA binding site [nucleotide binding]
395491002386	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
395491002387	DNA binding site [nucleotide binding]
395491002388	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
395491002389	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491002390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002391	dimer interface [polypeptide binding]; other site
395491002392	conserved gate region; other site
395491002393	putative PBP binding loops; other site
395491002394	ABC-ATPase subunit interface; other site
395491002395	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491002396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002397	dimer interface [polypeptide binding]; other site
395491002398	conserved gate region; other site
395491002399	putative PBP binding loops; other site
395491002400	ABC-ATPase subunit interface; other site
395491002401	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491002402	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491002403	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491002404	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491002405	Walker A/P-loop; other site
395491002406	ATP binding site [chemical binding]; other site
395491002407	Q-loop/lid; other site
395491002408	ABC transporter signature motif; other site
395491002409	Walker B; other site
395491002410	D-loop; other site
395491002411	H-loop/switch region; other site
395491002412	TOBE domain; Region: TOBE; pfam03459
395491002413	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491002414	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
395491002415	putative NAD(P) binding site [chemical binding]; other site
395491002416	active site
395491002417	putative substrate binding site [chemical binding]; other site
395491002418	transcriptional regulator NanR; Provisional; Region: PRK03837
395491002419	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491002420	DNA-binding site [nucleotide binding]; DNA binding site
395491002421	FCD domain; Region: FCD; pfam07729
395491002422	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
395491002423	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
395491002424	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
395491002425	active site
395491002426	DNA binding site [nucleotide binding]
395491002427	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
395491002428	DNA binding site [nucleotide binding]
395491002429	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
395491002430	nucleotide binding site [chemical binding]; other site
395491002431	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
395491002432	transmembrane helices; other site
395491002433	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
395491002434	TrkA-C domain; Region: TrkA_C; pfam02080
395491002435	TrkA-C domain; Region: TrkA_C; pfam02080
395491002436	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
395491002437	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
395491002438	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491002439	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491
395491002440	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
395491002441	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491002442	putative active site [active]
395491002443	catalytic residue [active]
395491002444	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
395491002445	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
395491002446	dimer interface [polypeptide binding]; other site
395491002447	NADP binding site [chemical binding]; other site
395491002448	catalytic residues [active]
395491002449	hypothetical protein; Validated; Region: PRK08245
395491002450	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
395491002451	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
395491002452	active site pocket [active]
395491002453	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
395491002454	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491002455	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491002456	DNA-binding site [nucleotide binding]; DNA binding site
395491002457	FCD domain; Region: FCD; pfam07729
395491002458	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
395491002459	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
395491002460	putative ligand binding site [chemical binding]; other site
395491002461	NAD binding site [chemical binding]; other site
395491002462	catalytic site [active]
395491002463	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395491002464	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491002465	Walker A/P-loop; other site
395491002466	ATP binding site [chemical binding]; other site
395491002467	Q-loop/lid; other site
395491002468	ABC transporter signature motif; other site
395491002469	Walker B; other site
395491002470	D-loop; other site
395491002471	H-loop/switch region; other site
395491002472	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491002473	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491002474	Walker A/P-loop; other site
395491002475	ATP binding site [chemical binding]; other site
395491002476	Q-loop/lid; other site
395491002477	ABC transporter signature motif; other site
395491002478	Walker B; other site
395491002479	D-loop; other site
395491002480	H-loop/switch region; other site
395491002481	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
395491002482	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491002483	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002484	dimer interface [polypeptide binding]; other site
395491002485	conserved gate region; other site
395491002486	putative PBP binding loops; other site
395491002487	ABC-ATPase subunit interface; other site
395491002488	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491002489	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002490	dimer interface [polypeptide binding]; other site
395491002491	conserved gate region; other site
395491002492	putative PBP binding loops; other site
395491002493	ABC-ATPase subunit interface; other site
395491002494	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
395491002495	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
395491002496	nudix motif; other site
395491002497	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
395491002498	putative catalytic residues [active]
395491002499	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491002500	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491002501	Walker A/P-loop; other site
395491002502	ATP binding site [chemical binding]; other site
395491002503	Q-loop/lid; other site
395491002504	ABC transporter signature motif; other site
395491002505	Walker B; other site
395491002506	D-loop; other site
395491002507	H-loop/switch region; other site
395491002508	TOBE domain; Region: TOBE_2; pfam08402
395491002509	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013
395491002510	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
395491002511	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
395491002512	dimer interface [polypeptide binding]; other site
395491002513	active site
395491002514	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
395491002515	active site
395491002516	dimer interface [polypeptide binding]; other site
395491002517	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491002518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002519	dimer interface [polypeptide binding]; other site
395491002520	conserved gate region; other site
395491002521	putative PBP binding loops; other site
395491002522	ABC-ATPase subunit interface; other site
395491002523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002524	dimer interface [polypeptide binding]; other site
395491002525	conserved gate region; other site
395491002526	putative PBP binding loops; other site
395491002527	ABC-ATPase subunit interface; other site
395491002528	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395491002529	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491002530	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
395491002531	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
395491002532	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
395491002533	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
395491002534	alpha-galactosidase; Provisional; Region: PRK15076
395491002535	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
395491002536	NAD binding site [chemical binding]; other site
395491002537	sugar binding site [chemical binding]; other site
395491002538	divalent metal binding site [ion binding]; other site
395491002539	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
395491002540	dimer interface [polypeptide binding]; other site
395491002541	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
395491002542	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491002543	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491002544	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
395491002545	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
395491002546	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
395491002547	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
395491002548	active site
395491002549	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491002550	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002551	dimer interface [polypeptide binding]; other site
395491002552	conserved gate region; other site
395491002553	putative PBP binding loops; other site
395491002554	ABC-ATPase subunit interface; other site
395491002555	ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176
395491002556	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
395491002557	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395491002558	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395491002559	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491002560	Walker A/P-loop; other site
395491002561	ATP binding site [chemical binding]; other site
395491002562	Q-loop/lid; other site
395491002563	ABC transporter signature motif; other site
395491002564	Walker B; other site
395491002565	D-loop; other site
395491002566	H-loop/switch region; other site
395491002567	TOBE domain; Region: TOBE_2; pfam08402
395491002568	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491002569	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491002570	substrate binding pocket [chemical binding]; other site
395491002571	membrane-bound complex binding site; other site
395491002572	hinge residues; other site
395491002573	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491002574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002575	dimer interface [polypeptide binding]; other site
395491002576	conserved gate region; other site
395491002577	putative PBP binding loops; other site
395491002578	ABC-ATPase subunit interface; other site
395491002579	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
395491002580	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491002581	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491002582	DNA-binding site [nucleotide binding]; DNA binding site
395491002583	FCD domain; Region: FCD; pfam07729
395491002584	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
395491002585	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
395491002586	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395491002587	Zn2+ binding site [ion binding]; other site
395491002588	Mg2+ binding site [ion binding]; other site
395491002589	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395491002590	GAF domain; Region: GAF; pfam01590
395491002591	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491002592	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491002593	metal binding site [ion binding]; metal-binding site
395491002594	active site
395491002595	I-site; other site
395491002596	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491002597	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395491002598	Histidine kinase; Region: HisKA_2; pfam07568
395491002599	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491002600	ATP binding site [chemical binding]; other site
395491002601	Mg2+ binding site [ion binding]; other site
395491002602	G-X-G motif; other site
395491002603	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
395491002604	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491002605	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491002606	DNA binding site [nucleotide binding]
395491002607	domain linker motif; other site
395491002608	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
395491002609	ligand binding site [chemical binding]; other site
395491002610	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491002611	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491002612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002613	dimer interface [polypeptide binding]; other site
395491002614	conserved gate region; other site
395491002615	putative PBP binding loops; other site
395491002616	ABC-ATPase subunit interface; other site
395491002617	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491002618	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002619	dimer interface [polypeptide binding]; other site
395491002620	conserved gate region; other site
395491002621	putative PBP binding loops; other site
395491002622	ABC-ATPase subunit interface; other site
395491002623	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491002624	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491002625	Walker A/P-loop; other site
395491002626	ATP binding site [chemical binding]; other site
395491002627	Q-loop/lid; other site
395491002628	ABC transporter signature motif; other site
395491002629	Walker B; other site
395491002630	D-loop; other site
395491002631	H-loop/switch region; other site
395491002632	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
395491002633	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
395491002634	AAA domain; Region: AAA_23; pfam13476
395491002635	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
395491002636	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
395491002637	active site
395491002638	metal binding site [ion binding]; metal-binding site
395491002639	DNA binding site [nucleotide binding]
395491002640	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395491002641	Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_RL0313; cd07148
395491002642	NAD(P) binding site [chemical binding]; other site
395491002643	catalytic residues [active]
395491002644	acetolactate synthase; Reviewed; Region: PRK08322
395491002645	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395491002646	PYR/PP interface [polypeptide binding]; other site
395491002647	dimer interface [polypeptide binding]; other site
395491002648	TPP binding site [chemical binding]; other site
395491002649	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395491002650	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
395491002651	TPP-binding site [chemical binding]; other site
395491002652	dimer interface [polypeptide binding]; other site
395491002653	hypothetical protein; Validated; Region: PRK08245
395491002654	Transcriptional regulator [Transcription]; Region: IclR; COG1414
395491002655	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
395491002656	Bacterial transcriptional regulator; Region: IclR; pfam01614
395491002657	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491002658	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
395491002659	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491002660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395491002661	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491002662	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002663	dimer interface [polypeptide binding]; other site
395491002664	conserved gate region; other site
395491002665	putative PBP binding loops; other site
395491002666	ABC-ATPase subunit interface; other site
395491002667	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
395491002668	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491002669	Walker A/P-loop; other site
395491002670	ATP binding site [chemical binding]; other site
395491002671	Q-loop/lid; other site
395491002672	ABC transporter signature motif; other site
395491002673	Walker B; other site
395491002674	D-loop; other site
395491002675	H-loop/switch region; other site
395491002676	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395491002677	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
395491002678	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491002679	Walker A/P-loop; other site
395491002680	ATP binding site [chemical binding]; other site
395491002681	Q-loop/lid; other site
395491002682	ABC transporter signature motif; other site
395491002683	Walker B; other site
395491002684	D-loop; other site
395491002685	H-loop/switch region; other site
395491002686	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395491002687	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
395491002688	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
395491002689	protein binding site [polypeptide binding]; other site
395491002690	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
395491002691	Catalytic dyad [active]
395491002692	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
395491002693	MEKHLA domain; Region: MEKHLA; pfam08670
395491002694	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
395491002695	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
395491002696	metal binding site [ion binding]; metal-binding site
395491002697	putative dimer interface [polypeptide binding]; other site
395491002698	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395491002699	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491002700	Walker A/P-loop; other site
395491002701	ATP binding site [chemical binding]; other site
395491002702	Q-loop/lid; other site
395491002703	ABC transporter signature motif; other site
395491002704	Walker B; other site
395491002705	D-loop; other site
395491002706	H-loop/switch region; other site
395491002707	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491002708	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491002709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491002710	dimer interface [polypeptide binding]; other site
395491002711	conserved gate region; other site
395491002712	putative PBP binding loops; other site
395491002713	ABC-ATPase subunit interface; other site
395491002714	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491002715	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491002716	substrate binding pocket [chemical binding]; other site
395491002717	membrane-bound complex binding site; other site
395491002718	hinge residues; other site
395491002719	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395491002720	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
395491002721	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491002722	DNA-binding site [nucleotide binding]; DNA binding site
395491002723	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491002724	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491002725	homodimer interface [polypeptide binding]; other site
395491002726	catalytic residue [active]
395491002727	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491002728	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491002729	active site
395491002730	phosphorylation site [posttranslational modification]
395491002731	intermolecular recognition site; other site
395491002732	dimerization interface [polypeptide binding]; other site
395491002733	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
395491002734	DNA binding residues [nucleotide binding]
395491002735	DnaA N-terminal domain; Region: DnaA_N; pfam11638
395491002736	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
395491002737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491002738	Walker A motif; other site
395491002739	ATP binding site [chemical binding]; other site
395491002740	Walker B motif; other site
395491002741	arginine finger; other site
395491002742	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
395491002743	DnaA box-binding interface [nucleotide binding]; other site
395491002744	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
395491002745	TrkA-N domain; Region: TrkA_N; pfam02254
395491002746	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
395491002747	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395491002748	FeS/SAM binding site; other site
395491002749	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
395491002750	active site
395491002751	dimerization interface [polypeptide binding]; other site
395491002752	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
395491002753	putative metal binding site [ion binding]; other site
395491002754	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491002755	ribonuclease PH; Reviewed; Region: rph; PRK00173
395491002756	Ribonuclease PH; Region: RNase_PH_bact; cd11362
395491002757	hexamer interface [polypeptide binding]; other site
395491002758	active site
395491002759	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
395491002760	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
395491002761	DNA-binding site [nucleotide binding]; DNA binding site
395491002762	heat shock protein GrpE; Provisional; Region: PRK14141
395491002763	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
395491002764	dimer interface [polypeptide binding]; other site
395491002765	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
395491002766	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
395491002767	active site
395491002768	tetramer interface [polypeptide binding]; other site
395491002769	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395491002770	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
395491002771	putative dimer interface [polypeptide binding]; other site
395491002772	Uncharacterized small protein [Function unknown]; Region: COG5568
395491002773	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
395491002774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491002775	S-adenosylmethionine binding site [chemical binding]; other site
395491002776	S-adenosylmethionine synthetase; Validated; Region: PRK05250
395491002777	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
395491002778	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
395491002779	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
395491002780	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491002781	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491002782	non-specific DNA binding site [nucleotide binding]; other site
395491002783	salt bridge; other site
395491002784	sequence-specific DNA binding site [nucleotide binding]; other site
395491002785	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
395491002786	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
395491002787	putative active site [active]
395491002788	catalytic triad [active]
395491002789	putative dimer interface [polypeptide binding]; other site
395491002790	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491002791	cyclase homology domain; Region: CHD; cd07302
395491002792	nucleotidyl binding site; other site
395491002793	metal binding site [ion binding]; metal-binding site
395491002794	dimer interface [polypeptide binding]; other site
395491002795	Domain of unknown function DUF302; Region: DUF302; cl01364
395491002796	Predicted amidohydrolase [General function prediction only]; Region: COG0388
395491002797	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
395491002798	putative active site [active]
395491002799	catalytic triad [active]
395491002800	putative dimer interface [polypeptide binding]; other site
395491002801	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
395491002802	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
395491002803	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491002804	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
395491002805	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491002806	DNA-binding site [nucleotide binding]; DNA binding site
395491002807	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491002808	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491002809	homodimer interface [polypeptide binding]; other site
395491002810	catalytic residue [active]
395491002811	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395491002812	Uncharacterized conserved protein [Function unknown]; Region: COG2128
395491002813	chorismate mutase; Provisional; Region: PRK09239
395491002814	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
395491002815	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
395491002816	Transporter associated domain; Region: CorC_HlyC; smart01091
395491002817	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
395491002818	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
395491002819	PhoH-like protein; Region: PhoH; pfam02562
395491002820	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
395491002821	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
395491002822	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395491002823	FeS/SAM binding site; other site
395491002824	TRAM domain; Region: TRAM; cl01282
395491002825	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395491002826	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395491002827	putative acyl-acceptor binding pocket; other site
395491002828	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395491002829	metal binding site 2 [ion binding]; metal-binding site
395491002830	putative DNA binding helix; other site
395491002831	metal binding site 1 [ion binding]; metal-binding site
395491002832	dimer interface [polypeptide binding]; other site
395491002833	structural Zn2+ binding site [ion binding]; other site
395491002834	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395491002835	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491002836	Coenzyme A binding pocket [chemical binding]; other site
395491002837	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
395491002838	Glycoprotease family; Region: Peptidase_M22; pfam00814
395491002839	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
395491002840	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
395491002841	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395491002842	Ligand Binding Site [chemical binding]; other site
395491002843	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
395491002844	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
395491002845	active site
395491002846	HIGH motif; other site
395491002847	dimer interface [polypeptide binding]; other site
395491002848	KMSKS motif; other site
395491002849	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
395491002850	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491002851	Peptidase M15; Region: Peptidase_M15_3; cl01194
395491002852	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491002853	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491002854	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491002855	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491002856	NAD(P) binding site [chemical binding]; other site
395491002857	active site
395491002858	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
395491002859	MviN-like protein; Region: MVIN; pfam03023
395491002860	PII uridylyl-transferase; Provisional; Region: PRK05092
395491002861	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
395491002862	metal binding triad; other site
395491002863	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
395491002864	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395491002865	Zn2+ binding site [ion binding]; other site
395491002866	Mg2+ binding site [ion binding]; other site
395491002867	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
395491002868	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
395491002869	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
395491002870	MutS domain I; Region: MutS_I; pfam01624
395491002871	MutS domain II; Region: MutS_II; pfam05188
395491002872	MutS domain III; Region: MutS_III; pfam05192
395491002873	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
395491002874	Walker A/P-loop; other site
395491002875	ATP binding site [chemical binding]; other site
395491002876	Q-loop/lid; other site
395491002877	ABC transporter signature motif; other site
395491002878	Walker B; other site
395491002879	D-loop; other site
395491002880	H-loop/switch region; other site
395491002881	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
395491002882	Malic enzyme, N-terminal domain; Region: malic; pfam00390
395491002883	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
395491002884	putative NAD(P) binding site [chemical binding]; other site
395491002885	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
395491002886	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491002887	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491002888	Putative hemolysin [General function prediction only]; Region: COG3176
395491002889	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491002890	dimer interface [polypeptide binding]; other site
395491002891	phosphorylation site [posttranslational modification]
395491002892	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491002893	ATP binding site [chemical binding]; other site
395491002894	Mg2+ binding site [ion binding]; other site
395491002895	G-X-G motif; other site
395491002896	Response regulator receiver domain; Region: Response_reg; pfam00072
395491002897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491002898	active site
395491002899	phosphorylation site [posttranslational modification]
395491002900	intermolecular recognition site; other site
395491002901	dimerization interface [polypeptide binding]; other site
395491002902	lipoprotein signal peptidase; Provisional; Region: PRK14795
395491002903	lipoprotein signal peptidase; Provisional; Region: PRK14787
395491002904	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
395491002905	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
395491002906	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
395491002907	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
395491002908	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
395491002909	dimer interface [polypeptide binding]; other site
395491002910	ADP-ribose binding site [chemical binding]; other site
395491002911	active site
395491002912	nudix motif; other site
395491002913	metal binding site [ion binding]; metal-binding site
395491002914	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
395491002915	putative hydrophobic ligand binding site [chemical binding]; other site
395491002916	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395491002917	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491002918	Coenzyme A binding pocket [chemical binding]; other site
395491002919	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
395491002920	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395491002921	IHF dimer interface [polypeptide binding]; other site
395491002922	IHF - DNA interface [nucleotide binding]; other site
395491002923	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
395491002924	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
395491002925	tandem repeat interface [polypeptide binding]; other site
395491002926	oligomer interface [polypeptide binding]; other site
395491002927	active site residues [active]
395491002928	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
395491002929	OstA-like protein; Region: OstA; pfam03968
395491002930	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
395491002931	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
395491002932	Walker A/P-loop; other site
395491002933	ATP binding site [chemical binding]; other site
395491002934	Q-loop/lid; other site
395491002935	ABC transporter signature motif; other site
395491002936	Walker B; other site
395491002937	D-loop; other site
395491002938	H-loop/switch region; other site
395491002939	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
395491002940	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
395491002941	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
395491002942	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
395491002943	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
395491002944	EamA-like transporter family; Region: EamA; pfam00892
395491002945	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
395491002946	30S subunit binding site; other site
395491002947	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
395491002948	active site
395491002949	phosphorylation site [posttranslational modification]
395491002950	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491002951	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
395491002952	substrate binding site [chemical binding]; other site
395491002953	dimer interface [polypeptide binding]; other site
395491002954	ATP binding site [chemical binding]; other site
395491002955	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
395491002956	RmuC family; Region: RmuC; pfam02646
395491002957	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
395491002958	heme-binding site [chemical binding]; other site
395491002959	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491002960	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491002961	dimer interface [polypeptide binding]; other site
395491002962	putative CheW interface [polypeptide binding]; other site
395491002963	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
395491002964	active site
395491002965	catalytic residues [active]
395491002966	metal binding site [ion binding]; metal-binding site
395491002967	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
395491002968	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
395491002969	oligomeric interface; other site
395491002970	putative active site [active]
395491002971	homodimer interface [polypeptide binding]; other site
395491002972	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
395491002973	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
395491002974	putative active site [active]
395491002975	substrate binding site [chemical binding]; other site
395491002976	putative cosubstrate binding site; other site
395491002977	catalytic site [active]
395491002978	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
395491002979	substrate binding site [chemical binding]; other site
395491002980	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
395491002981	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
395491002982	dimerization interface 3.5A [polypeptide binding]; other site
395491002983	active site
395491002984	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
395491002985	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
395491002986	metal binding site [ion binding]; metal-binding site
395491002987	dimer interface [polypeptide binding]; other site
395491002988	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
395491002989	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
395491002990	trimer interface [polypeptide binding]; other site
395491002991	active site
395491002992	substrate binding site [chemical binding]; other site
395491002993	CoA binding site [chemical binding]; other site
395491002994	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
395491002995	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
395491002996	Ca2+ binding site [ion binding]; other site
395491002997	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
395491002998	Ca2+ binding site [ion binding]; other site
395491002999	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
395491003000	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
395491003001	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
395491003002	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
395491003003	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
395491003004	DNA binding site [nucleotide binding]
395491003005	active site
395491003006	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
395491003007	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
395491003008	tetramer interface [polypeptide binding]; other site
395491003009	active site
395491003010	Mg2+/Mn2+ binding site [ion binding]; other site
395491003011	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
395491003012	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395491003013	phosphate binding site [ion binding]; other site
395491003014	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
395491003015	homohexameric interface [polypeptide binding]; other site
395491003016	feedback inhibition sensing region; other site
395491003017	carbamate kinase; Reviewed; Region: PRK12686
395491003018	nucleotide binding site [chemical binding]; other site
395491003019	N-acetyl-L-glutamate binding site [chemical binding]; other site
395491003020	RNA polymerase sigma factor; Provisional; Region: PRK12514
395491003021	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491003022	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491003023	DNA binding residues [nucleotide binding]
395491003024	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
395491003025	Anti-sigma-K factor rskA; Region: RskA; pfam10099
395491003026	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
395491003027	Fasciclin domain; Region: Fasciclin; pfam02469
395491003028	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395491003029	Histidine kinase; Region: HisKA_2; pfam07568
395491003030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491003031	ATP binding site [chemical binding]; other site
395491003032	Mg2+ binding site [ion binding]; other site
395491003033	G-X-G motif; other site
395491003034	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395491003035	DNA-binding site [nucleotide binding]; DNA binding site
395491003036	RNA-binding motif; other site
395491003037	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
395491003038	G1 box; other site
395491003039	GTP/Mg2+ binding site [chemical binding]; other site
395491003040	Switch I region; other site
395491003041	G2 box; other site
395491003042	G3 box; other site
395491003043	Switch II region; other site
395491003044	G4 box; other site
395491003045	G5 box; other site
395491003046	membrane protein insertase; Provisional; Region: PRK01318
395491003047	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
395491003048	ribonuclease P; Reviewed; Region: rnpA; PRK01313
395491003049	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
395491003050	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491003051	dimerization interface [polypeptide binding]; other site
395491003052	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491003053	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491003054	dimer interface [polypeptide binding]; other site
395491003055	putative CheW interface [polypeptide binding]; other site
395491003056	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491003057	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
395491003058	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491003059	ATP binding site [chemical binding]; other site
395491003060	Mg2+ binding site [ion binding]; other site
395491003061	G-X-G motif; other site
395491003062	Predicted integral membrane protein [Function unknown]; Region: COG5616
395491003063	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491003064	TPR motif; other site
395491003065	binding surface
395491003066	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491003067	binding surface
395491003068	TPR motif; other site
395491003069	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491003070	Domain found in IF2B/IF5; Region: eIF-5_eIF-2B; cl17014
395491003071	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395491003072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491003073	S-adenosylmethionine binding site [chemical binding]; other site
395491003074	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491003075	S-adenosylmethionine binding site [chemical binding]; other site
395491003076	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
395491003077	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491003078	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491003079	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491003080	active site
395491003081	catalytic tetrad [active]
395491003082	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
395491003083	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
395491003084	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395491003085	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
395491003086	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
395491003087	putative NAD(P) binding site [chemical binding]; other site
395491003088	putative active site [active]
395491003089	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
395491003090	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
395491003091	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395491003092	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395491003093	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491003094	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491003095	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395491003096	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491003097	NAD(P) binding site [chemical binding]; other site
395491003098	active site
395491003099	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491003100	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491003101	metal binding site [ion binding]; metal-binding site
395491003102	active site
395491003103	I-site; other site
395491003104	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491003105	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
395491003106	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395491003107	putative switch regulator; other site
395491003108	non-specific DNA interactions [nucleotide binding]; other site
395491003109	DNA binding site [nucleotide binding]
395491003110	sequence specific DNA binding site [nucleotide binding]; other site
395491003111	putative cAMP binding site [chemical binding]; other site
395491003112	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491003113	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395491003114	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491003115	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
395491003116	ligand binding site [chemical binding]; other site
395491003117	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491003118	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491003119	TM-ABC transporter signature motif; other site
395491003120	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395491003121	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491003122	Walker A/P-loop; other site
395491003123	ATP binding site [chemical binding]; other site
395491003124	Q-loop/lid; other site
395491003125	ABC transporter signature motif; other site
395491003126	Walker B; other site
395491003127	D-loop; other site
395491003128	H-loop/switch region; other site
395491003129	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
395491003130	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
395491003131	active site
395491003132	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
395491003133	active site
395491003134	substrate binding pocket [chemical binding]; other site
395491003135	dimer interface [polypeptide binding]; other site
395491003136	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491003137	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491003138	metal binding site [ion binding]; metal-binding site
395491003139	active site
395491003140	I-site; other site
395491003141	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
395491003142	dimer interface [polypeptide binding]; other site
395491003143	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491003144	ligand binding site [chemical binding]; other site
395491003145	Transposase; Region: DEDD_Tnp_IS110; pfam01548
395491003146	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
395491003147	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
395491003148	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491003149	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
395491003150	putative C-terminal domain interface [polypeptide binding]; other site
395491003151	putative GSH binding site (G-site) [chemical binding]; other site
395491003152	putative dimer interface [polypeptide binding]; other site
395491003153	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395491003154	N-terminal domain interface [polypeptide binding]; other site
395491003155	dimer interface [polypeptide binding]; other site
395491003156	substrate binding pocket (H-site) [chemical binding]; other site
395491003157	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
395491003158	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491003159	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
395491003160	NAD(P) binding site [chemical binding]; other site
395491003161	active site
395491003162	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491003163	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491003164	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395491003165	active site
395491003166	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491003167	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
395491003168	putative substrate binding site [chemical binding]; other site
395491003169	putative ATP binding site [chemical binding]; other site
395491003170	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491003171	dimerization interface [polypeptide binding]; other site
395491003172	putative DNA binding site [nucleotide binding]; other site
395491003173	putative Zn2+ binding site [ion binding]; other site
395491003174	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
395491003175	Di-iron ligands [ion binding]; other site
395491003176	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
395491003177	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
395491003178	active site
395491003179	homotetramer interface [polypeptide binding]; other site
395491003180	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
395491003181	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
395491003182	active site
395491003183	dimer interface [polypeptide binding]; other site
395491003184	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
395491003185	dimer interface [polypeptide binding]; other site
395491003186	active site
395491003187	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
395491003188	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
395491003189	acyl-activating enzyme (AAE) consensus motif; other site
395491003190	putative AMP binding site [chemical binding]; other site
395491003191	putative active site [active]
395491003192	putative CoA binding site [chemical binding]; other site
395491003193	PRC-barrel domain; Region: PRC; pfam05239
395491003194	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
395491003195	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
395491003196	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
395491003197	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491003198	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395491003199	active site
395491003200	metal binding site [ion binding]; metal-binding site
395491003201	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
395491003202	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
395491003203	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491003204	Walker A/P-loop; other site
395491003205	ATP binding site [chemical binding]; other site
395491003206	Q-loop/lid; other site
395491003207	ABC transporter signature motif; other site
395491003208	Walker B; other site
395491003209	D-loop; other site
395491003210	H-loop/switch region; other site
395491003211	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
395491003212	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
395491003213	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491003214	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491003215	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491003216	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491003217	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395491003218	dimerization interface [polypeptide binding]; other site
395491003219	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
395491003220	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
395491003221	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395491003222	putative NAD(P) binding site [chemical binding]; other site
395491003223	catalytic Zn binding site [ion binding]; other site
395491003224	structural Zn binding site [ion binding]; other site
395491003225	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491003226	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491003227	TM-ABC transporter signature motif; other site
395491003228	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491003229	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491003230	Walker A/P-loop; other site
395491003231	ATP binding site [chemical binding]; other site
395491003232	Q-loop/lid; other site
395491003233	ABC transporter signature motif; other site
395491003234	Walker B; other site
395491003235	D-loop; other site
395491003236	H-loop/switch region; other site
395491003237	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491003238	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491003239	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
395491003240	putative ligand binding site [chemical binding]; other site
395491003241	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
395491003242	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491003243	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491003244	active site
395491003245	catalytic tetrad [active]
395491003246	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
395491003247	galactarate dehydratase; Region: galactar-dH20; TIGR03248
395491003248	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
395491003249	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491003250	DNA-binding site [nucleotide binding]; DNA binding site
395491003251	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491003252	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
395491003253	DNA-binding site [nucleotide binding]; DNA binding site
395491003254	FCD domain; Region: FCD; pfam07729
395491003255	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395491003256	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395491003257	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
395491003258	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
395491003259	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
395491003260	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395491003261	MarR family; Region: MarR_2; pfam12802
395491003262	SnoaL-like domain; Region: SnoaL_2; pfam12680
395491003263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491003264	S-adenosylmethionine binding site [chemical binding]; other site
395491003265	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391
395491003266	AAA domain; Region: AAA_18; pfam13238
395491003267	P-loop motif; other site
395491003268	ATP binding site [chemical binding]; other site
395491003269	Chloramphenicol (Cm) binding site [chemical binding]; other site
395491003270	catalytic residue [active]
395491003271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491003272	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491003273	putative substrate translocation pore; other site
395491003274	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
395491003275	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
395491003276	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
395491003277	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
395491003278	FMN binding site [chemical binding]; other site
395491003279	substrate binding site [chemical binding]; other site
395491003280	putative catalytic residue [active]
395491003281	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
395491003282	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395491003283	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491003284	dimer interface [polypeptide binding]; other site
395491003285	phosphorylation site [posttranslational modification]
395491003286	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491003287	ATP binding site [chemical binding]; other site
395491003288	Mg2+ binding site [ion binding]; other site
395491003289	G-X-G motif; other site
395491003290	PBP superfamily domain; Region: PBP_like_2; pfam12849
395491003291	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
395491003292	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
395491003293	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491003294	dimer interface [polypeptide binding]; other site
395491003295	conserved gate region; other site
395491003296	putative PBP binding loops; other site
395491003297	ABC-ATPase subunit interface; other site
395491003298	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
395491003299	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
395491003300	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491003301	dimer interface [polypeptide binding]; other site
395491003302	conserved gate region; other site
395491003303	putative PBP binding loops; other site
395491003304	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395491003305	ABC-ATPase subunit interface; other site
395491003306	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
395491003307	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
395491003308	Walker A/P-loop; other site
395491003309	ATP binding site [chemical binding]; other site
395491003310	Q-loop/lid; other site
395491003311	ABC transporter signature motif; other site
395491003312	Walker B; other site
395491003313	D-loop; other site
395491003314	H-loop/switch region; other site
395491003315	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
395491003316	PhoU domain; Region: PhoU; pfam01895
395491003317	PhoU domain; Region: PhoU; pfam01895
395491003318	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
395491003319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491003320	active site
395491003321	phosphorylation site [posttranslational modification]
395491003322	intermolecular recognition site; other site
395491003323	dimerization interface [polypeptide binding]; other site
395491003324	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491003325	DNA binding site [nucleotide binding]
395491003326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352
395491003327	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
395491003328	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395491003329	inhibitor-cofactor binding pocket; inhibition site
395491003330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491003331	catalytic residue [active]
395491003332	ornithine carbamoyltransferase; Provisional; Region: PRK00779
395491003333	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
395491003334	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
395491003335	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
395491003336	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
395491003337	dimerization interface [polypeptide binding]; other site
395491003338	domain crossover interface; other site
395491003339	redox-dependent activation switch; other site
395491003340	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
395491003341	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
395491003342	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
395491003343	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
395491003344	homodimer interface [polypeptide binding]; other site
395491003345	substrate-cofactor binding pocket; other site
395491003346	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491003347	catalytic residue [active]
395491003348	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
395491003349	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
395491003350	trimer interface [polypeptide binding]; other site
395491003351	active site
395491003352	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
395491003353	trimer interface [polypeptide binding]; other site
395491003354	active site
395491003355	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395491003356	active site
395491003357	Int/Topo IB signature motif; other site
395491003358	DNA binding site [nucleotide binding]
395491003359	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491003360	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
395491003361	Walker A motif; other site
395491003362	ATP binding site [chemical binding]; other site
395491003363	Walker B motif; other site
395491003364	arginine finger; other site
395491003365	Peptidase family M41; Region: Peptidase_M41; pfam01434
395491003366	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491003367	Walker A/P-loop; other site
395491003368	ATP binding site [chemical binding]; other site
395491003369	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
395491003370	Walker B; other site
395491003371	D-loop; other site
395491003372	H-loop/switch region; other site
395491003373	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
395491003374	Protein of unknown function (DUF499); Region: DUF499; pfam04465
395491003375	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
395491003376	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
395491003377	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
395491003378	TIGR02646 family protein; Region: TIGR02646
395491003379	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
395491003380	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491003381	Walker A/P-loop; other site
395491003382	ATP binding site [chemical binding]; other site
395491003383	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491003384	Q-loop/lid; other site
395491003385	Walker B; other site
395491003386	D-loop; other site
395491003387	H-loop/switch region; other site
395491003388	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395491003389	ATP binding site [chemical binding]; other site
395491003390	putative Mg++ binding site [ion binding]; other site
395491003391	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
395491003392	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491003393	nucleotide binding region [chemical binding]; other site
395491003394	ATP-binding site [chemical binding]; other site
395491003395	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
395491003396	Domain of unknown function DUF87; Region: DUF87; pfam01935
395491003397	HerA helicase [Replication, recombination, and repair]; Region: COG0433
395491003398	SIR2-like domain; Region: SIR2_2; pfam13289
395491003399	Protein of unknown function (DUF995); Region: DUF995; pfam06191
395491003400	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
395491003401	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
395491003402	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395491003403	active site
395491003404	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
395491003405	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
395491003406	NAD binding site [chemical binding]; other site
395491003407	homodimer interface [polypeptide binding]; other site
395491003408	active site
395491003409	substrate binding site [chemical binding]; other site
395491003410	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491003411	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
395491003412	NAD binding site [chemical binding]; other site
395491003413	putative substrate binding site 2 [chemical binding]; other site
395491003414	putative substrate binding site 1 [chemical binding]; other site
395491003415	active site
395491003416	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491003417	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491003418	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491003419	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395491003420	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395491003421	HAMP domain; Region: HAMP; pfam00672
395491003422	dimerization interface [polypeptide binding]; other site
395491003423	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491003424	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491003425	dimer interface [polypeptide binding]; other site
395491003426	putative CheW interface [polypeptide binding]; other site
395491003427	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491003428	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491003429	substrate binding pocket [chemical binding]; other site
395491003430	membrane-bound complex binding site; other site
395491003431	hinge residues; other site
395491003432	tellurite resistance protein terB; Region: terB; cd07176
395491003433	putative metal binding site [ion binding]; other site
395491003434	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
395491003435	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
395491003436	Predicted transcriptional regulator [Transcription]; Region: COG2932
395491003437	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
395491003438	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
395491003439	Catalytic site [active]
395491003440	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491003441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491003442	active site
395491003443	phosphorylation site [posttranslational modification]
395491003444	intermolecular recognition site; other site
395491003445	dimerization interface [polypeptide binding]; other site
395491003446	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491003447	DNA binding residues [nucleotide binding]
395491003448	dimerization interface [polypeptide binding]; other site
395491003449	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
395491003450	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
395491003451	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
395491003452	quinone interaction residues [chemical binding]; other site
395491003453	active site
395491003454	catalytic residues [active]
395491003455	FMN binding site [chemical binding]; other site
395491003456	substrate binding site [chemical binding]; other site
395491003457	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
395491003458	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
395491003459	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
395491003460	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
395491003461	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
395491003462	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395491003463	Methyltransferase domain; Region: Methyltransf_12; pfam08242
395491003464	S-adenosylmethionine binding site [chemical binding]; other site
395491003465	Uncharacterized conserved protein [Function unknown]; Region: COG1284
395491003466	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
395491003467	Uncharacterized conserved protein [Function unknown]; Region: COG2128
395491003468	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395491003469	Predicted transcriptional regulator [Transcription]; Region: COG1959
395491003470	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491003471	dimerization interface [polypeptide binding]; other site
395491003472	putative Zn2+ binding site [ion binding]; other site
395491003473	putative DNA binding site [nucleotide binding]; other site
395491003474	Uncharacterized conserved protein [Function unknown]; Region: COG1284
395491003475	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
395491003476	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
395491003477	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395491003478	ATP binding site [chemical binding]; other site
395491003479	putative Mg++ binding site [ion binding]; other site
395491003480	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491003481	nucleotide binding region [chemical binding]; other site
395491003482	ATP-binding site [chemical binding]; other site
395491003483	DEAD/H associated; Region: DEAD_assoc; pfam08494
395491003484	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395491003485	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
395491003486	putative active site [active]
395491003487	putative metal binding site [ion binding]; other site
395491003488	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395491003489	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395491003490	catalytic residue [active]
395491003491	RibD C-terminal domain; Region: RibD_C; cl17279
395491003492	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
395491003493	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826
395491003494	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395491003495	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395491003496	Sel1-like repeats; Region: SEL1; smart00671
395491003497	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
395491003498	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491003499	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491003500	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
395491003501	dimer interface [polypeptide binding]; other site
395491003502	putative metal binding site [ion binding]; other site
395491003503	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
395491003504	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491003505	NAD(P) binding site [chemical binding]; other site
395491003506	active site
395491003507	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
395491003508	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
395491003509	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
395491003510	FAD binding site [chemical binding]; other site
395491003511	substrate binding site [chemical binding]; other site
395491003512	catalytic residues [active]
395491003513	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
395491003514	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
395491003515	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
395491003516	dimer interface [polypeptide binding]; other site
395491003517	active site
395491003518	Cupin domain; Region: Cupin_2; cl17218
395491003519	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
395491003520	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395491003521	substrate binding site [chemical binding]; other site
395491003522	oxyanion hole (OAH) forming residues; other site
395491003523	trimer interface [polypeptide binding]; other site
395491003524	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
395491003525	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395491003526	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395491003527	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
395491003528	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395491003529	DNA-binding site [nucleotide binding]; DNA binding site
395491003530	RNA-binding motif; other site
395491003531	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491003532	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491003533	dimerization interface [polypeptide binding]; other site
395491003534	putative Zn2+ binding site [ion binding]; other site
395491003535	putative DNA binding site [nucleotide binding]; other site
395491003536	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491003537	SnoaL-like domain; Region: SnoaL_3; pfam13474
395491003538	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
395491003539	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491003540	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491003541	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
395491003542	Na binding site [ion binding]; other site
395491003543	PAS fold; Region: PAS_7; pfam12860
395491003544	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491003545	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491003546	dimer interface [polypeptide binding]; other site
395491003547	phosphorylation site [posttranslational modification]
395491003548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491003549	ATP binding site [chemical binding]; other site
395491003550	Mg2+ binding site [ion binding]; other site
395491003551	G-X-G motif; other site
395491003552	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491003553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491003554	active site
395491003555	phosphorylation site [posttranslational modification]
395491003556	intermolecular recognition site; other site
395491003557	dimerization interface [polypeptide binding]; other site
395491003558	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
395491003559	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
395491003560	aspartate aminotransferase; Provisional; Region: PRK06108
395491003561	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491003562	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491003563	homodimer interface [polypeptide binding]; other site
395491003564	catalytic residue [active]
395491003565	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
395491003566	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
395491003567	NAD binding site [chemical binding]; other site
395491003568	homodimer interface [polypeptide binding]; other site
395491003569	active site
395491003570	substrate binding site [chemical binding]; other site
395491003571	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
395491003572	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491003573	metal binding site [ion binding]; metal-binding site
395491003574	active site
395491003575	I-site; other site
395491003576	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491003577	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
395491003578	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395491003579	substrate binding site [chemical binding]; other site
395491003580	oxyanion hole (OAH) forming residues; other site
395491003581	trimer interface [polypeptide binding]; other site
395491003582	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
395491003583	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
395491003584	Part of AAA domain; Region: AAA_19; pfam13245
395491003585	Family description; Region: UvrD_C_2; pfam13538
395491003586	BON domain; Region: BON; cl02771
395491003587	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491003588	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
395491003589	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
395491003590	hinge; other site
395491003591	active site
395491003592	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
395491003593	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
395491003594	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
395491003595	NAD binding site [chemical binding]; other site
395491003596	dimerization interface [polypeptide binding]; other site
395491003597	product binding site; other site
395491003598	substrate binding site [chemical binding]; other site
395491003599	zinc binding site [ion binding]; other site
395491003600	catalytic residues [active]
395491003601	hypothetical protein; Provisional; Region: PRK02853
395491003602	Low molecular weight phosphatase family; Region: LMWPc; cd00115
395491003603	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
395491003604	active site
395491003605	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
395491003606	rRNA binding site [nucleotide binding]; other site
395491003607	predicted 30S ribosome binding site; other site
395491003608	Maf-like protein; Region: Maf; pfam02545
395491003609	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
395491003610	active site
395491003611	dimer interface [polypeptide binding]; other site
395491003612	zinc-binding protein; Provisional; Region: PRK01343
395491003613	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491003614	non-specific DNA binding site [nucleotide binding]; other site
395491003615	salt bridge; other site
395491003616	sequence-specific DNA binding site [nucleotide binding]; other site
395491003617	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
395491003618	DNA-binding interface [nucleotide binding]; DNA binding site
395491003619	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
395491003620	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
395491003621	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491003622	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
395491003623	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491003624	Walker A/P-loop; other site
395491003625	ATP binding site [chemical binding]; other site
395491003626	Q-loop/lid; other site
395491003627	ABC transporter signature motif; other site
395491003628	Walker B; other site
395491003629	D-loop; other site
395491003630	H-loop/switch region; other site
395491003631	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491003632	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491003633	DNA binding residues [nucleotide binding]
395491003634	dimerization interface [polypeptide binding]; other site
395491003635	short chain dehydrogenase; Provisional; Region: PRK07060
395491003636	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491003637	NAD(P) binding site [chemical binding]; other site
395491003638	active site
395491003639	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491003640	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491003641	Walker A/P-loop; other site
395491003642	ATP binding site [chemical binding]; other site
395491003643	Q-loop/lid; other site
395491003644	ABC transporter signature motif; other site
395491003645	Walker B; other site
395491003646	D-loop; other site
395491003647	H-loop/switch region; other site
395491003648	TOBE domain; Region: TOBE_2; pfam08402
395491003649	Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294
395491003650	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491003651	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491003652	dimer interface [polypeptide binding]; other site
395491003653	conserved gate region; other site
395491003654	putative PBP binding loops; other site
395491003655	ABC-ATPase subunit interface; other site
395491003656	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491003657	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491003658	dimer interface [polypeptide binding]; other site
395491003659	conserved gate region; other site
395491003660	putative PBP binding loops; other site
395491003661	ABC-ATPase subunit interface; other site
395491003662	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491003663	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491003664	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491003665	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
395491003666	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491003667	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
395491003668	nucleotide binding site [chemical binding]; other site
395491003669	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395491003670	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491003671	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
395491003672	substrate binding site [chemical binding]; other site
395491003673	ATP binding site [chemical binding]; other site
395491003674	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013
395491003675	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
395491003676	classical (c) SDRs; Region: SDR_c; cd05233
395491003677	NAD(P) binding site [chemical binding]; other site
395491003678	active site
395491003679	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491003680	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491003681	NAD(P) binding site [chemical binding]; other site
395491003682	active site
395491003683	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
395491003684	Class I aldolases; Region: Aldolase_Class_I; cl17187
395491003685	catalytic residue [active]
395491003686	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491003687	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491003688	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
395491003689	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491003690	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
395491003691	substrate binding site [chemical binding]; other site
395491003692	ATP binding site [chemical binding]; other site
395491003693	sorbitol dehydrogenase; Provisional; Region: PRK07067
395491003694	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491003695	NAD(P) binding site [chemical binding]; other site
395491003696	active site
395491003697	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395491003698	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
395491003699	putative NAD(P) binding site [chemical binding]; other site
395491003700	catalytic Zn binding site [ion binding]; other site
395491003701	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491003702	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491003703	DNA binding site [nucleotide binding]
395491003704	domain linker motif; other site
395491003705	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491003706	dimerization interface [polypeptide binding]; other site
395491003707	ligand binding site [chemical binding]; other site
395491003708	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491003709	Right handed beta helix region; Region: Beta_helix; pfam13229
395491003710	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395491003711	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
395491003712	O-Antigen ligase; Region: Wzy_C; pfam04932
395491003713	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
395491003714	active site
395491003715	catalytic triad [active]
395491003716	oxyanion hole [active]
395491003717	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
395491003718	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
395491003719	DNA binding site [nucleotide binding]
395491003720	heterodimer interface [polypeptide binding]; other site
395491003721	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
395491003722	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
395491003723	putative DNA binding site [nucleotide binding]; other site
395491003724	putative homodimer interface [polypeptide binding]; other site
395491003725	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
395491003726	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
395491003727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
395491003728	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
395491003729	EamA-like transporter family; Region: EamA; pfam00892
395491003730	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
395491003731	EamA-like transporter family; Region: EamA; pfam00892
395491003732	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
395491003733	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491003734	Zn binding site [ion binding]; other site
395491003735	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
395491003736	Zn binding site [ion binding]; other site
395491003737	Predicted esterase [General function prediction only]; Region: COG0400
395491003738	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491003739	Response regulator receiver domain; Region: Response_reg; pfam00072
395491003740	active site
395491003741	phosphorylation site [posttranslational modification]
395491003742	intermolecular recognition site; other site
395491003743	dimerization interface [polypeptide binding]; other site
395491003744	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491003745	dimer interface [polypeptide binding]; other site
395491003746	phosphorylation site [posttranslational modification]
395491003747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491003748	ATP binding site [chemical binding]; other site
395491003749	Mg2+ binding site [ion binding]; other site
395491003750	G-X-G motif; other site
395491003751	Response regulator receiver domain; Region: Response_reg; pfam00072
395491003752	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491003753	active site
395491003754	phosphorylation site [posttranslational modification]
395491003755	intermolecular recognition site; other site
395491003756	dimerization interface [polypeptide binding]; other site
395491003757	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491003758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491003759	active site
395491003760	phosphorylation site [posttranslational modification]
395491003761	intermolecular recognition site; other site
395491003762	dimerization interface [polypeptide binding]; other site
395491003763	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395491003764	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491003765	putative active site [active]
395491003766	heme pocket [chemical binding]; other site
395491003767	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491003768	dimer interface [polypeptide binding]; other site
395491003769	phosphorylation site [posttranslational modification]
395491003770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491003771	ATP binding site [chemical binding]; other site
395491003772	Mg2+ binding site [ion binding]; other site
395491003773	G-X-G motif; other site
395491003774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491003775	active site
395491003776	phosphorylation site [posttranslational modification]
395491003777	intermolecular recognition site; other site
395491003778	dimerization interface [polypeptide binding]; other site
395491003779	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491003780	DNA binding residues [nucleotide binding]
395491003781	dimerization interface [polypeptide binding]; other site
395491003782	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491003783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491003784	active site
395491003785	phosphorylation site [posttranslational modification]
395491003786	intermolecular recognition site; other site
395491003787	dimerization interface [polypeptide binding]; other site
395491003788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
395491003789	dimer interface [polypeptide binding]; other site
395491003790	phosphorylation site [posttranslational modification]
395491003791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491003792	ATP binding site [chemical binding]; other site
395491003793	Mg2+ binding site [ion binding]; other site
395491003794	G-X-G motif; other site
395491003795	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
395491003796	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
395491003797	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
395491003798	Protein export membrane protein; Region: SecD_SecF; pfam02355
395491003799	putative cation:proton antiport protein; Provisional; Region: PRK10669
395491003800	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
395491003801	TrkA-N domain; Region: TrkA_N; pfam02254
395491003802	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491003803	non-specific DNA binding site [nucleotide binding]; other site
395491003804	salt bridge; other site
395491003805	sequence-specific DNA binding site [nucleotide binding]; other site
395491003806	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
395491003807	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
395491003808	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
395491003809	heme-binding site [chemical binding]; other site
395491003810	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491003811	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491003812	dimer interface [polypeptide binding]; other site
395491003813	putative CheW interface [polypeptide binding]; other site
395491003814	STAS domain; Region: STAS_2; pfam13466
395491003815	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491003816	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491003817	active site
395491003818	phosphorylation site [posttranslational modification]
395491003819	intermolecular recognition site; other site
395491003820	dimerization interface [polypeptide binding]; other site
395491003821	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
395491003822	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
395491003823	putative binding surface; other site
395491003824	active site
395491003825	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
395491003826	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491003827	ATP binding site [chemical binding]; other site
395491003828	Mg2+ binding site [ion binding]; other site
395491003829	G-X-G motif; other site
395491003830	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
395491003831	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
395491003832	putative CheA interaction surface; other site
395491003833	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
395491003834	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
395491003835	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
395491003836	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
395491003837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491003838	active site
395491003839	phosphorylation site [posttranslational modification]
395491003840	intermolecular recognition site; other site
395491003841	dimerization interface [polypeptide binding]; other site
395491003842	CheB methylesterase; Region: CheB_methylest; pfam01339
395491003843	Response regulator receiver domain; Region: Response_reg; pfam00072
395491003844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491003845	active site
395491003846	phosphorylation site [posttranslational modification]
395491003847	intermolecular recognition site; other site
395491003848	dimerization interface [polypeptide binding]; other site
395491003849	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13497
395491003850	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
395491003851	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
395491003852	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
395491003853	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491003854	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491003855	DNA binding residues [nucleotide binding]
395491003856	dimerization interface [polypeptide binding]; other site
395491003857	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491003858	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491003859	DNA binding residues [nucleotide binding]
395491003860	dimerization interface [polypeptide binding]; other site
395491003861	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
395491003862	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
395491003863	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
395491003864	FliG C-terminal domain; Region: FliG_C; pfam01706
395491003865	flagellar motor switch protein FliN; Region: fliN; TIGR02480
395491003866	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
395491003867	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
395491003868	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
395491003869	flagellar motor protein MotA; Validated; Region: PRK09110
395491003870	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
395491003871	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
395491003872	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
395491003873	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
395491003874	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395491003875	Walker A motif; other site
395491003876	ATP binding site [chemical binding]; other site
395491003877	Walker B motif; other site
395491003878	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
395491003879	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
395491003880	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
395491003881	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
395491003882	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
395491003883	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
395491003884	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
395491003885	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
395491003886	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
395491003887	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
395491003888	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
395491003889	Uncharacterized conserved protein [Function unknown]; Region: COG3334
395491003890	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
395491003891	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
395491003892	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
395491003893	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
395491003894	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
395491003895	flagellin; Reviewed; Region: PRK12687
395491003896	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395491003897	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395491003898	flagellin; Reviewed; Region: PRK12687
395491003899	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395491003900	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395491003901	flagellin; Reviewed; Region: PRK12687
395491003902	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395491003903	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395491003904	flagellin; Reviewed; Region: PRK12687
395491003905	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395491003906	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395491003907	flagellar motor protein MotB; Validated; Region: motB; PRK05996
395491003908	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
395491003909	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395491003910	ligand binding site [chemical binding]; other site
395491003911	chemotaxis protein; Reviewed; Region: PRK12798
395491003912	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
395491003913	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395491003914	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395491003915	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395491003916	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491003917	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491003918	DNA binding site [nucleotide binding]
395491003919	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
395491003920	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
395491003921	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
395491003922	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
395491003923	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
395491003924	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
395491003925	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395491003926	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395491003927	Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442
395491003928	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
395491003929	Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443
395491003930	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
395491003931	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
395491003932	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
395491003933	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
395491003934	FHIPEP family; Region: FHIPEP; pfam00771
395491003935	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
395491003936	Rod binding protein; Region: Rod-binding; pfam10135
395491003937	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
395491003938	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
395491003939	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
395491003940	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
395491003941	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
395491003942	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
395491003943	homodimer interface [polypeptide binding]; other site
395491003944	NADP binding site [chemical binding]; other site
395491003945	substrate binding site [chemical binding]; other site
395491003946	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491003947	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491003948	DNA binding site [nucleotide binding]
395491003949	domain linker motif; other site
395491003950	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
395491003951	ligand binding site [chemical binding]; other site
395491003952	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491003953	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
395491003954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491003955	putative PBP binding loops; other site
395491003956	dimer interface [polypeptide binding]; other site
395491003957	ABC-ATPase subunit interface; other site
395491003958	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491003959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491003960	dimer interface [polypeptide binding]; other site
395491003961	conserved gate region; other site
395491003962	putative PBP binding loops; other site
395491003963	ABC-ATPase subunit interface; other site
395491003964	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
395491003965	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
395491003966	active site
395491003967	catalytic site [active]
395491003968	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491003969	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491003970	Walker A/P-loop; other site
395491003971	ATP binding site [chemical binding]; other site
395491003972	Q-loop/lid; other site
395491003973	ABC transporter signature motif; other site
395491003974	Walker B; other site
395491003975	D-loop; other site
395491003976	H-loop/switch region; other site
395491003977	TOBE domain; Region: TOBE; pfam03459
395491003978	TOBE domain; Region: TOBE_2; pfam08402
395491003979	phosphogluconate dehydratase; Validated; Region: PRK09054
395491003980	6-phosphogluconate dehydratase; Region: edd; TIGR01196
395491003981	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
395491003982	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
395491003983	putative active site [active]
395491003984	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
395491003985	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
395491003986	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
395491003987	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
395491003988	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491003989	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
395491003990	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
395491003991	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395491003992	Predicted flavoproteins [General function prediction only]; Region: COG2081
395491003993	hydroxyglutarate oxidase; Provisional; Region: PRK11728
395491003994	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491003995	dimerization interface [polypeptide binding]; other site
395491003996	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491003997	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491003998	dimer interface [polypeptide binding]; other site
395491003999	putative CheW interface [polypeptide binding]; other site
395491004000	HAMP domain; Region: HAMP; pfam00672
395491004001	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491004002	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491004003	dimer interface [polypeptide binding]; other site
395491004004	putative CheW interface [polypeptide binding]; other site
395491004005	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491004006	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491004007	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491004008	isocitrate lyase; Provisional; Region: PRK15063
395491004009	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
395491004010	tetramer interface [polypeptide binding]; other site
395491004011	active site
395491004012	Mg2+/Mn2+ binding site [ion binding]; other site
395491004013	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491004014	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491004015	non-specific DNA binding site [nucleotide binding]; other site
395491004016	salt bridge; other site
395491004017	sequence-specific DNA binding site [nucleotide binding]; other site
395491004018	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
395491004019	Domain of unknown function (DUF955); Region: DUF955; pfam06114
395491004020	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
395491004021	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395491004022	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395491004023	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395491004024	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
395491004025	Walker A/P-loop; other site
395491004026	ATP binding site [chemical binding]; other site
395491004027	Q-loop/lid; other site
395491004028	ABC transporter signature motif; other site
395491004029	Walker B; other site
395491004030	D-loop; other site
395491004031	H-loop/switch region; other site
395491004032	TOBE domain; Region: TOBE_2; pfam08402
395491004033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491004034	dimer interface [polypeptide binding]; other site
395491004035	conserved gate region; other site
395491004036	putative PBP binding loops; other site
395491004037	ABC-ATPase subunit interface; other site
395491004038	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491004039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491004040	dimer interface [polypeptide binding]; other site
395491004041	conserved gate region; other site
395491004042	putative PBP binding loops; other site
395491004043	ABC-ATPase subunit interface; other site
395491004044	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
395491004045	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
395491004046	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
395491004047	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
395491004048	acyl-activating enzyme (AAE) consensus motif; other site
395491004049	putative AMP binding site [chemical binding]; other site
395491004050	putative active site [active]
395491004051	putative CoA binding site [chemical binding]; other site
395491004052	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395491004053	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491004054	putative active site [active]
395491004055	heme pocket [chemical binding]; other site
395491004056	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491004057	dimer interface [polypeptide binding]; other site
395491004058	phosphorylation site [posttranslational modification]
395491004059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491004060	ATP binding site [chemical binding]; other site
395491004061	Mg2+ binding site [ion binding]; other site
395491004062	G-X-G motif; other site
395491004063	Phasin protein; Region: Phasin_2; cl11491
395491004064	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
395491004065	adhesin; Provisional; Region: PRK09752
395491004066	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491004067	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491004068	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491004069	dimerization interface [polypeptide binding]; other site
395491004070	Uncharacterized conserved protein [Function unknown]; Region: COG1359
395491004071	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
395491004072	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
395491004073	tetrameric interface [polypeptide binding]; other site
395491004074	NAD binding site [chemical binding]; other site
395491004075	catalytic residues [active]
395491004076	iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920
395491004077	Rrf2 family protein; Region: rrf2_super; TIGR00738
395491004078	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491004079	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
395491004080	peptide binding site [polypeptide binding]; other site
395491004081	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491004082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491004083	dimer interface [polypeptide binding]; other site
395491004084	conserved gate region; other site
395491004085	putative PBP binding loops; other site
395491004086	ABC-ATPase subunit interface; other site
395491004087	dipeptide transporter; Provisional; Region: PRK10913
395491004088	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
395491004089	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491004090	dimer interface [polypeptide binding]; other site
395491004091	conserved gate region; other site
395491004092	putative PBP binding loops; other site
395491004093	ABC-ATPase subunit interface; other site
395491004094	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
395491004095	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491004096	Walker A/P-loop; other site
395491004097	ATP binding site [chemical binding]; other site
395491004098	Q-loop/lid; other site
395491004099	ABC transporter signature motif; other site
395491004100	Walker B; other site
395491004101	D-loop; other site
395491004102	H-loop/switch region; other site
395491004103	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
395491004104	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
395491004105	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491004106	Walker A/P-loop; other site
395491004107	ATP binding site [chemical binding]; other site
395491004108	Q-loop/lid; other site
395491004109	ABC transporter signature motif; other site
395491004110	Walker B; other site
395491004111	D-loop; other site
395491004112	H-loop/switch region; other site
395491004113	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395491004114	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
395491004115	AAA domain; Region: AAA_33; pfam13671
395491004116	ATP-binding site [chemical binding]; other site
395491004117	Gluconate-6-phosphate binding site [chemical binding]; other site
395491004118	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491004119	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395491004120	Phospholipid methyltransferase; Region: PEMT; cl17370
395491004121	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
395491004122	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
395491004123	malonyl-CoA binding site [chemical binding]; other site
395491004124	dimer interface [polypeptide binding]; other site
395491004125	active site
395491004126	product binding site; other site
395491004127	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491004128	TPR motif; other site
395491004129	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395491004130	binding surface
395491004131	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
395491004132	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491004133	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491004134	DNA binding residues [nucleotide binding]
395491004135	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
395491004136	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
395491004137	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
395491004138	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
395491004139	substrate binding site; other site
395491004140	tetramer interface; other site
395491004141	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
395491004142	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
395491004143	NADP binding site [chemical binding]; other site
395491004144	active site
395491004145	putative substrate binding site [chemical binding]; other site
395491004146	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
395491004147	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
395491004148	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
395491004149	NADP binding site [chemical binding]; other site
395491004150	active site
395491004151	putative substrate binding site [chemical binding]; other site
395491004152	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
395491004153	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
395491004154	NADP-binding site; other site
395491004155	homotetramer interface [polypeptide binding]; other site
395491004156	substrate binding site [chemical binding]; other site
395491004157	homodimer interface [polypeptide binding]; other site
395491004158	active site
395491004159	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
395491004160	NeuB family; Region: NeuB; pfam03102
395491004161	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
395491004162	NeuB binding interface [polypeptide binding]; other site
395491004163	putative substrate binding site [chemical binding]; other site
395491004164	short chain dehydrogenase; Provisional; Region: PRK06841
395491004165	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491004166	NAD(P) binding site [chemical binding]; other site
395491004167	active site
395491004168	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395491004169	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
395491004170	NAD(P) binding site [chemical binding]; other site
395491004171	catalytic residues [active]
395491004172	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
395491004173	ligand binding site; other site
395491004174	tetramer interface; other site
395491004175	transketolase; Reviewed; Region: PRK05899
395491004176	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
395491004177	TPP-binding site [chemical binding]; other site
395491004178	dimer interface [polypeptide binding]; other site
395491004179	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
395491004180	PYR/PP interface [polypeptide binding]; other site
395491004181	dimer interface [polypeptide binding]; other site
395491004182	TPP binding site [chemical binding]; other site
395491004183	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395491004184	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
395491004185	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
395491004186	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
395491004187	trimer interface [polypeptide binding]; other site
395491004188	active site
395491004189	substrate binding site [chemical binding]; other site
395491004190	CoA binding site [chemical binding]; other site
395491004191	Methyltransferase domain; Region: Methyltransf_24; pfam13578
395491004192	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491004193	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
395491004194	NAD(P) binding site [chemical binding]; other site
395491004195	active site
395491004196	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491004197	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395491004198	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
395491004199	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395491004200	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
395491004201	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
395491004202	Walker A/P-loop; other site
395491004203	ATP binding site [chemical binding]; other site
395491004204	Q-loop/lid; other site
395491004205	ABC transporter signature motif; other site
395491004206	Walker B; other site
395491004207	D-loop; other site
395491004208	H-loop/switch region; other site
395491004209	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
395491004210	putative carbohydrate binding site [chemical binding]; other site
395491004211	Methyltransferase domain; Region: Methyltransf_24; pfam13578
395491004212	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395491004213	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395491004214	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395491004215	active site
395491004216	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
395491004217	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491004218	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
395491004219	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
395491004220	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
395491004221	Probable Catalytic site; other site
395491004222	metal-binding site
395491004223	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
395491004224	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
395491004225	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
395491004226	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
395491004227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491004228	S-adenosylmethionine binding site [chemical binding]; other site
395491004229	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
395491004230	DNA-binding interface [nucleotide binding]; DNA binding site
395491004231	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
395491004232	MobA/MobL family; Region: MobA_MobL; pfam03389
395491004233	AAA domain; Region: AAA_30; pfam13604
395491004234	Family description; Region: UvrD_C_2; pfam13538
395491004235	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395491004236	active site
395491004237	NTP binding site [chemical binding]; other site
395491004238	metal binding triad [ion binding]; metal-binding site
395491004239	antibiotic binding site [chemical binding]; other site
395491004240	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
395491004241	exopolyphosphatase; Region: exo_poly_only; TIGR03706
395491004242	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
395491004243	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
395491004244	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491004245	S-adenosylmethionine binding site [chemical binding]; other site
395491004246	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
395491004247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491004248	putative substrate translocation pore; other site
395491004249	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
395491004250	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
395491004251	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
395491004252	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395491004253	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
395491004254	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
395491004255	active site
395491004256	MAPEG family; Region: MAPEG; cl09190
395491004257	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
395491004258	Autotransporter beta-domain; Region: Autotransporter; pfam03797
395491004259	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491004260	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491004261	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
395491004262	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491004263	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491004264	dimerization interface [polypeptide binding]; other site
395491004265	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
395491004266	Uncharacterized conserved protein [Function unknown]; Region: COG5403
395491004267	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
395491004268	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
395491004269	RNA methyltransferase, RsmE family; Region: TIGR00046
395491004270	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
395491004271	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
395491004272	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
395491004273	nudix motif; other site
395491004274	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491004275	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491004276	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491004277	dimerization interface [polypeptide binding]; other site
395491004278	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
395491004279	NAD binding site [chemical binding]; other site
395491004280	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
395491004281	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395491004282	putative NAD(P) binding site [chemical binding]; other site
395491004283	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491004284	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491004285	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395491004286	dimerization interface [polypeptide binding]; other site
395491004287	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491004288	transcriptional activator TtdR; Provisional; Region: PRK09801
395491004289	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491004290	putative effector binding pocket; other site
395491004291	dimerization interface [polypeptide binding]; other site
395491004292	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
395491004293	FAD binding domain; Region: FAD_binding_4; pfam01565
395491004294	FAD binding domain; Region: FAD_binding_4; pfam01565
395491004295	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
395491004296	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
395491004297	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
395491004298	Cysteine-rich domain; Region: CCG; pfam02754
395491004299	Cysteine-rich domain; Region: CCG; pfam02754
395491004300	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
395491004301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395491004302	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491004303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395491004304	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491004305	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
395491004306	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
395491004307	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491004308	motif II; other site
395491004309	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491004310	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491004311	active site
395491004312	catalytic tetrad [active]
395491004313	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
395491004314	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
395491004315	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
395491004316	dimer interface [polypeptide binding]; other site
395491004317	motif 1; other site
395491004318	active site
395491004319	motif 2; other site
395491004320	motif 3; other site
395491004321	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
395491004322	anticodon binding site; other site
395491004323	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
395491004324	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395491004325	motif 1; other site
395491004326	dimer interface [polypeptide binding]; other site
395491004327	active site
395491004328	motif 2; other site
395491004329	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395491004330	motif 3; other site
395491004331	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
395491004332	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
395491004333	Predicted membrane protein [Function unknown]; Region: COG2259
395491004334	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
395491004335	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
395491004336	C-terminal domain interface [polypeptide binding]; other site
395491004337	GSH binding site (G-site) [chemical binding]; other site
395491004338	dimer interface [polypeptide binding]; other site
395491004339	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
395491004340	dimer interface [polypeptide binding]; other site
395491004341	N-terminal domain interface [polypeptide binding]; other site
395491004342	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
395491004343	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
395491004344	ring oligomerisation interface [polypeptide binding]; other site
395491004345	ATP/Mg binding site [chemical binding]; other site
395491004346	stacking interactions; other site
395491004347	hinge regions; other site
395491004348	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
395491004349	oligomerisation interface [polypeptide binding]; other site
395491004350	mobile loop; other site
395491004351	roof hairpin; other site
395491004352	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
395491004353	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
395491004354	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
395491004355	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
395491004356	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
395491004357	active site
395491004358	Riboflavin kinase; Region: Flavokinase; smart00904
395491004359	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
395491004360	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395491004361	active site
395491004362	HIGH motif; other site
395491004363	nucleotide binding site [chemical binding]; other site
395491004364	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
395491004365	active site
395491004366	KMSKS motif; other site
395491004367	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
395491004368	tRNA binding surface [nucleotide binding]; other site
395491004369	anticodon binding site; other site
395491004370	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
395491004371	nucleoside/Zn binding site; other site
395491004372	dimer interface [polypeptide binding]; other site
395491004373	catalytic motif [active]
395491004374	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
395491004375	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395491004376	RNA binding surface [nucleotide binding]; other site
395491004377	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
395491004378	active site
395491004379	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
395491004380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491004381	S-adenosylmethionine binding site [chemical binding]; other site
395491004382	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395491004383	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
395491004384	nucleophile elbow; other site
395491004385	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
395491004386	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
395491004387	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
395491004388	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
395491004389	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
395491004390	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
395491004391	TrkA-N domain; Region: TrkA_N; pfam02254
395491004392	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
395491004393	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395491004394	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
395491004395	active site
395491004396	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
395491004397	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
395491004398	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
395491004399	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
395491004400	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491004401	motif II; other site
395491004402	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
395491004403	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
395491004404	cell density-dependent motility repressor; Provisional; Region: PRK10082
395491004405	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491004406	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395491004407	dimerization interface [polypeptide binding]; other site
395491004408	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
395491004409	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
395491004410	homodimer interface [polypeptide binding]; other site
395491004411	substrate-cofactor binding pocket; other site
395491004412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491004413	catalytic residue [active]
395491004414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
395491004415	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
395491004416	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491004417	ATP binding site [chemical binding]; other site
395491004418	Mg2+ binding site [ion binding]; other site
395491004419	G-X-G motif; other site
395491004420	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
395491004421	ATP binding site [chemical binding]; other site
395491004422	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
395491004423	PAS fold; Region: PAS_7; pfam12860
395491004424	PAS fold; Region: PAS_4; pfam08448
395491004425	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491004426	putative active site [active]
395491004427	heme pocket [chemical binding]; other site
395491004428	Response regulator receiver domain; Region: Response_reg; pfam00072
395491004429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491004430	active site
395491004431	phosphorylation site [posttranslational modification]
395491004432	intermolecular recognition site; other site
395491004433	dimerization interface [polypeptide binding]; other site
395491004434	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491004435	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491004436	metal binding site [ion binding]; metal-binding site
395491004437	active site
395491004438	I-site; other site
395491004439	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491004440	PRC-barrel domain; Region: PRC; pfam05239
395491004441	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
395491004442	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
395491004443	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
395491004444	active site
395491004445	intersubunit interface [polypeptide binding]; other site
395491004446	catalytic residue [active]
395491004447	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
395491004448	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
395491004449	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
395491004450	classical (c) SDRs; Region: SDR_c; cd05233
395491004451	NAD(P) binding site [chemical binding]; other site
395491004452	active site
395491004453	Transcriptional regulator [Transcription]; Region: IclR; COG1414
395491004454	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
395491004455	Bacterial transcriptional regulator; Region: IclR; pfam01614
395491004456	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395491004457	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491004458	dimerization interface [polypeptide binding]; other site
395491004459	DNA binding residues [nucleotide binding]
395491004460	Domain of unknown function DUF59; Region: DUF59; pfam01883
395491004461	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
395491004462	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
395491004463	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
395491004464	Cl binding site [ion binding]; other site
395491004465	oligomer interface [polypeptide binding]; other site
395491004466	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
395491004467	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
395491004468	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
395491004469	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
395491004470	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
395491004471	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
395491004472	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
395491004473	F0F1 ATP synthase subunit B'; Validated; Region: PRK09174
395491004474	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
395491004475	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
395491004476	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395491004477	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395491004478	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
395491004479	RNA/DNA hybrid binding site [nucleotide binding]; other site
395491004480	active site
395491004481	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
395491004482	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395491004483	FeS/SAM binding site; other site
395491004484	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
395491004485	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395491004486	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
395491004487	MPT binding site; other site
395491004488	trimer interface [polypeptide binding]; other site
395491004489	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
395491004490	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491004491	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491004492	TPR motif; other site
395491004493	binding surface
395491004494	TPR repeat; Region: TPR_11; pfam13414
395491004495	TPR repeat; Region: TPR_11; pfam13414
395491004496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491004497	binding surface
395491004498	TPR motif; other site
395491004499	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395491004500	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
395491004501	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
395491004502	substrate binding pocket [chemical binding]; other site
395491004503	chain length determination region; other site
395491004504	substrate-Mg2+ binding site; other site
395491004505	catalytic residues [active]
395491004506	aspartate-rich region 1; other site
395491004507	active site lid residues [active]
395491004508	aspartate-rich region 2; other site
395491004509	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
395491004510	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
395491004511	Methyltransferase domain; Region: Methyltransf_26; pfam13659
395491004512	manganese transport protein MntH; Reviewed; Region: PRK00701
395491004513	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
395491004514	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
395491004515	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
395491004516	tandem repeat interface [polypeptide binding]; other site
395491004517	oligomer interface [polypeptide binding]; other site
395491004518	active site residues [active]
395491004519	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
395491004520	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
395491004521	dimer interface [polypeptide binding]; other site
395491004522	motif 1; other site
395491004523	active site
395491004524	motif 2; other site
395491004525	motif 3; other site
395491004526	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
395491004527	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
395491004528	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
395491004529	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
395491004530	hinge; other site
395491004531	active site
395491004532	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
395491004533	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
395491004534	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
395491004535	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
395491004536	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
395491004537	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
395491004538	HAMP domain; Region: HAMP; pfam00672
395491004539	dimerization interface [polypeptide binding]; other site
395491004540	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395491004541	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491004542	dimer interface [polypeptide binding]; other site
395491004543	putative CheW interface [polypeptide binding]; other site
395491004544	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
395491004545	HAMP domain; Region: HAMP; pfam00672
395491004546	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395491004547	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491004548	dimer interface [polypeptide binding]; other site
395491004549	putative CheW interface [polypeptide binding]; other site
395491004550	Uncharacterized conserved protein [Function unknown]; Region: COG1683
395491004551	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
395491004552	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
395491004553	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
395491004554	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
395491004555	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
395491004556	RNA binding site [nucleotide binding]; other site
395491004557	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
395491004558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395491004559	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491004560	S-adenosylmethionine binding site [chemical binding]; other site
395491004561	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395491004562	catalytic core [active]
395491004563	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
395491004564	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
395491004565	UbiA prenyltransferase family; Region: UbiA; pfam01040
395491004566	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
395491004567	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
395491004568	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395491004569	catalytic residue [active]
395491004570	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491004571	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491004572	putative DNA binding site [nucleotide binding]; other site
395491004573	putative Zn2+ binding site [ion binding]; other site
395491004574	AsnC family; Region: AsnC_trans_reg; pfam01037
395491004575	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491004576	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491004577	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491004578	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491004579	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491004580	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491004581	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491004582	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491004583	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491004584	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395491004585	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
395491004586	FAD binding domain; Region: FAD_binding_4; pfam01565
395491004587	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
395491004588	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
395491004589	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
395491004590	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
395491004591	[2Fe-2S] cluster binding site [ion binding]; other site
395491004592	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
395491004593	putative alpha subunit interface [polypeptide binding]; other site
395491004594	putative active site [active]
395491004595	putative substrate binding site [chemical binding]; other site
395491004596	Fe binding site [ion binding]; other site
395491004597	BA14K-like protein; Region: BA14K; pfam07886
395491004598	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
395491004599	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
395491004600	Cl binding site [ion binding]; other site
395491004601	oligomer interface [polypeptide binding]; other site
395491004602	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395491004603	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395491004604	active site
395491004605	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
395491004606	enoyl-CoA hydratase; Provisional; Region: PRK06688
395491004607	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395491004608	substrate binding site [chemical binding]; other site
395491004609	oxyanion hole (OAH) forming residues; other site
395491004610	trimer interface [polypeptide binding]; other site
395491004611	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
395491004612	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
395491004613	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
395491004614	TRAM domain; Region: TRAM; cl01282
395491004615	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491004616	S-adenosylmethionine binding site [chemical binding]; other site
395491004617	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
395491004618	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395491004619	RNA binding surface [nucleotide binding]; other site
395491004620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491004621	S-adenosylmethionine binding site [chemical binding]; other site
395491004622	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
395491004623	CHASE3 domain; Region: CHASE3; cl05000
395491004624	HAMP domain; Region: HAMP; pfam00672
395491004625	dimerization interface [polypeptide binding]; other site
395491004626	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491004627	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491004628	dimer interface [polypeptide binding]; other site
395491004629	putative CheW interface [polypeptide binding]; other site
395491004630	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
395491004631	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
395491004632	TPP-binding site; other site
395491004633	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
395491004634	PYR/PP interface [polypeptide binding]; other site
395491004635	dimer interface [polypeptide binding]; other site
395491004636	TPP binding site [chemical binding]; other site
395491004637	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395491004638	Pirin-related protein [General function prediction only]; Region: COG1741
395491004639	Pirin; Region: Pirin; pfam02678
395491004640	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
395491004641	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491004642	classical (c) SDRs; Region: SDR_c; cd05233
395491004643	NAD(P) binding site [chemical binding]; other site
395491004644	active site
395491004645	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
395491004646	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
395491004647	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
395491004648	putative active site [active]
395491004649	Zn binding site [ion binding]; other site
395491004650	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
395491004651	active site 2 [active]
395491004652	active site 1 [active]
395491004653	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
395491004654	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491004655	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491004656	DNA-binding site [nucleotide binding]; DNA binding site
395491004657	FCD domain; Region: FCD; pfam07729
395491004658	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
395491004659	malonyl-CoA synthase; Validated; Region: PRK07514
395491004660	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
395491004661	acyl-activating enzyme (AAE) consensus motif; other site
395491004662	active site
395491004663	AMP binding site [chemical binding]; other site
395491004664	CoA binding site [chemical binding]; other site
395491004665	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
395491004666	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
395491004667	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
395491004668	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
395491004669	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
395491004670	active site
395491004671	HIGH motif; other site
395491004672	KMSKS motif; other site
395491004673	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
395491004674	anticodon binding site; other site
395491004675	tRNA binding surface [nucleotide binding]; other site
395491004676	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395491004677	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491004678	putative active site [active]
395491004679	heme pocket [chemical binding]; other site
395491004680	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491004681	dimer interface [polypeptide binding]; other site
395491004682	phosphorylation site [posttranslational modification]
395491004683	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491004684	ATP binding site [chemical binding]; other site
395491004685	Mg2+ binding site [ion binding]; other site
395491004686	G-X-G motif; other site
395491004687	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491004688	GXWXG protein; Region: GXWXG; pfam14231
395491004689	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
395491004690	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
395491004691	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
395491004692	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
395491004693	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
395491004694	Walker A/P-loop; other site
395491004695	ATP binding site [chemical binding]; other site
395491004696	Q-loop/lid; other site
395491004697	ABC transporter signature motif; other site
395491004698	Walker B; other site
395491004699	D-loop; other site
395491004700	H-loop/switch region; other site
395491004701	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
395491004702	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
395491004703	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314
395491004704	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
395491004705	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
395491004706	dimerization interface [polypeptide binding]; other site
395491004707	active site
395491004708	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
395491004709	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
395491004710	Tetramer interface [polypeptide binding]; other site
395491004711	active site
395491004712	FMN-binding site [chemical binding]; other site
395491004713	CHASE domain; Region: CHASE; cl01369
395491004714	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491004715	PAS fold; Region: PAS_3; pfam08447
395491004716	putative active site [active]
395491004717	heme pocket [chemical binding]; other site
395491004718	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491004719	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491004720	metal binding site [ion binding]; metal-binding site
395491004721	active site
395491004722	I-site; other site
395491004723	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491004724	Protein of unknown function (DUF1344); Region: DUF1344; pfam07076
395491004725	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395491004726	catalytic core [active]
395491004727	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
395491004728	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
395491004729	NAD binding site [chemical binding]; other site
395491004730	homotetramer interface [polypeptide binding]; other site
395491004731	homodimer interface [polypeptide binding]; other site
395491004732	substrate binding site [chemical binding]; other site
395491004733	active site
395491004734	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
395491004735	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395491004736	HSP70 interaction site [polypeptide binding]; other site
395491004737	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
395491004738	dimer interface [polypeptide binding]; other site
395491004739	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
395491004740	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
395491004741	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
395491004742	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
395491004743	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
395491004744	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
395491004745	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
395491004746	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
395491004747	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538
395491004748	metal binding site [ion binding]; metal-binding site
395491004749	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491004750	Coenzyme A binding pocket [chemical binding]; other site
395491004751	protease TldD; Provisional; Region: tldD; PRK10735
395491004752	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
395491004753	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
395491004754	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
395491004755	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
395491004756	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
395491004757	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
395491004758	Subunit I/III interface [polypeptide binding]; other site
395491004759	D-pathway; other site
395491004760	Subunit I/VIIc interface [polypeptide binding]; other site
395491004761	Subunit I/IV interface [polypeptide binding]; other site
395491004762	Subunit I/II interface [polypeptide binding]; other site
395491004763	Low-spin heme (heme a) binding site [chemical binding]; other site
395491004764	Subunit I/VIIa interface [polypeptide binding]; other site
395491004765	Subunit I/VIa interface [polypeptide binding]; other site
395491004766	Dimer interface; other site
395491004767	Putative water exit pathway; other site
395491004768	Binuclear center (heme a3/CuB) [ion binding]; other site
395491004769	K-pathway; other site
395491004770	Subunit I/Vb interface [polypeptide binding]; other site
395491004771	Putative proton exit pathway; other site
395491004772	Subunit I/VIb interface; other site
395491004773	Subunit I/VIc interface [polypeptide binding]; other site
395491004774	Electron transfer pathway; other site
395491004775	Subunit I/VIIIb interface [polypeptide binding]; other site
395491004776	Subunit I/VIIb interface [polypeptide binding]; other site
395491004777	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
395491004778	UbiA prenyltransferase family; Region: UbiA; pfam01040
395491004779	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
395491004780	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
395491004781	Subunit III/VIIa interface [polypeptide binding]; other site
395491004782	Phospholipid binding site [chemical binding]; other site
395491004783	Subunit I/III interface [polypeptide binding]; other site
395491004784	Subunit III/VIb interface [polypeptide binding]; other site
395491004785	Subunit III/VIa interface; other site
395491004786	Subunit III/Vb interface [polypeptide binding]; other site
395491004787	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391
395491004788	P-loop motif; other site
395491004789	ATP binding site [chemical binding]; other site
395491004790	Chloramphenicol (Cm) binding site [chemical binding]; other site
395491004791	catalytic residue [active]
395491004792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
395491004793	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
395491004794	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
395491004795	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
395491004796	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
395491004797	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
395491004798	putative active site [active]
395491004799	putative substrate binding site [chemical binding]; other site
395491004800	ATP binding site [chemical binding]; other site
395491004801	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
395491004802	RNA/DNA hybrid binding site [nucleotide binding]; other site
395491004803	active site
395491004804	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491004805	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491004806	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395491004807	putative effector binding pocket; other site
395491004808	putative dimerization interface [polypeptide binding]; other site
395491004809	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
395491004810	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
395491004811	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
395491004812	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
395491004813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
395491004814	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
395491004815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
395491004816	hypothetical protein; Validated; Region: PRK00228
395491004817	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
395491004818	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
395491004819	catalytic triad [active]
395491004820	dimer interface [polypeptide binding]; other site
395491004821	DoxX-like family; Region: DoxX_2; pfam13564
395491004822	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
395491004823	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
395491004824	short chain dehydrogenase; Provisional; Region: PRK12939
395491004825	NADP binding site [chemical binding]; other site
395491004826	substrate binding site [chemical binding]; other site
395491004827	active site
395491004828	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491004829	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491004830	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
395491004831	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
395491004832	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
395491004833	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491004834	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
395491004835	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491004836	dimerization interface [polypeptide binding]; other site
395491004837	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
395491004838	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
395491004839	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395491004840	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491004841	Walker A/P-loop; other site
395491004842	ATP binding site [chemical binding]; other site
395491004843	Q-loop/lid; other site
395491004844	ABC transporter signature motif; other site
395491004845	Walker B; other site
395491004846	D-loop; other site
395491004847	H-loop/switch region; other site
395491004848	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491004849	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491004850	substrate binding pocket [chemical binding]; other site
395491004851	membrane-bound complex binding site; other site
395491004852	hinge residues; other site
395491004853	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491004854	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491004855	dimer interface [polypeptide binding]; other site
395491004856	conserved gate region; other site
395491004857	putative PBP binding loops; other site
395491004858	ABC-ATPase subunit interface; other site
395491004859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491004860	dimer interface [polypeptide binding]; other site
395491004861	conserved gate region; other site
395491004862	ABC-ATPase subunit interface; other site
395491004863	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
395491004864	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
395491004865	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
395491004866	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491004867	ABC-ATPase subunit  interface; other site
395491004868	dimer interface [polypeptide binding]; other site
395491004869	putative PBP binding regions; other site
395491004870	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
395491004871	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
395491004872	metal binding site [ion binding]; metal-binding site
395491004873	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
395491004874	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
395491004875	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
395491004876	homotrimer interaction site [polypeptide binding]; other site
395491004877	putative active site [active]
395491004878	tetracycline repressor protein TetR; Provisional; Region: PRK13756
395491004879	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491004880	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
395491004881	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
395491004882	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
395491004883	Protein of unknown function (DUF938); Region: DUF938; pfam06080
395491004884	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
395491004885	Moco binding site; other site
395491004886	metal coordination site [ion binding]; other site
395491004887	dimerization interface [polypeptide binding]; other site
395491004888	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395491004889	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491004890	S-adenosylmethionine binding site [chemical binding]; other site
395491004891	AAA domain; Region: AAA_17; pfam13207
395491004892	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
395491004893	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
395491004894	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
395491004895	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491004896	PAS fold; Region: PAS_3; pfam08447
395491004897	putative active site [active]
395491004898	heme pocket [chemical binding]; other site
395491004899	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491004900	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491004901	metal binding site [ion binding]; metal-binding site
395491004902	active site
395491004903	I-site; other site
395491004904	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491004905	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395491004906	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
395491004907	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
395491004908	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
395491004909	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395491004910	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
395491004911	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
395491004912	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491004913	catalytic residue [active]
395491004914	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
395491004915	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
395491004916	motif I; other site
395491004917	active site
395491004918	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
395491004919	motif II; other site
395491004920	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
395491004921	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491004922	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491004923	dimer interface [polypeptide binding]; other site
395491004924	putative CheW interface [polypeptide binding]; other site
395491004925	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491004926	putative DNA binding site [nucleotide binding]; other site
395491004927	dimerization interface [polypeptide binding]; other site
395491004928	NIPSNAP; Region: NIPSNAP; pfam07978
395491004929	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
395491004930	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
395491004931	DNA methylase; Region: N6_N4_Mtase; pfam01555
395491004932	SnoaL-like domain; Region: SnoaL_2; pfam12680
395491004933	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
395491004934	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
395491004935	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
395491004936	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
395491004937	minor groove reading motif; other site
395491004938	helix-hairpin-helix signature motif; other site
395491004939	substrate binding pocket [chemical binding]; other site
395491004940	active site
395491004941	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
395491004942	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
395491004943	DNA binding and oxoG recognition site [nucleotide binding]
395491004944	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389
395491004945	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
395491004946	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491004947	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491004948	DNA binding site [nucleotide binding]
395491004949	domain linker motif; other site
395491004950	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491004951	ligand binding site [chemical binding]; other site
395491004952	dimerization interface [polypeptide binding]; other site
395491004953	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491004954	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491004955	Walker A/P-loop; other site
395491004956	ATP binding site [chemical binding]; other site
395491004957	Q-loop/lid; other site
395491004958	ABC transporter signature motif; other site
395491004959	Walker B; other site
395491004960	D-loop; other site
395491004961	H-loop/switch region; other site
395491004962	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491004963	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491004964	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491004965	TM-ABC transporter signature motif; other site
395491004966	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395491004967	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491004968	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
395491004969	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
395491004970	catalytic residues [active]
395491004971	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
395491004972	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
395491004973	Walker A/P-loop; other site
395491004974	ATP binding site [chemical binding]; other site
395491004975	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
395491004976	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
395491004977	ABC transporter signature motif; other site
395491004978	Walker B; other site
395491004979	D-loop; other site
395491004980	H-loop/switch region; other site
395491004981	pyruvate phosphate dikinase; Provisional; Region: PRK09279
395491004982	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
395491004983	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
395491004984	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
395491004985	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
395491004986	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
395491004987	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
395491004988	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
395491004989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
395491004990	Transposase; Region: HTH_Tnp_1; pfam01527
395491004991	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
395491004992	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
395491004993	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
395491004994	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
395491004995	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395491004996	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395491004997	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
395491004998	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
395491004999	daunorubicin C-13 ketoreductase (KR), classical (c)-like SDRs; Region: DR_C-13_KR_SDR_c_like; cd08951
395491005000	short chain dehydrogenase; Provisional; Region: PRK06197
395491005001	putative NAD(P) binding site [chemical binding]; other site
395491005002	active site
395491005003	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491005004	WHG domain; Region: WHG; pfam13305
395491005005	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
395491005006	yiaA/B two helix domain; Region: YiaAB; cl01759
395491005007	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
395491005008	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491005009	putative substrate translocation pore; other site
395491005010	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395491005011	putative acyl-acceptor binding pocket; other site
395491005012	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
395491005013	acyl-activating enzyme (AAE) consensus motif; other site
395491005014	putative AMP binding site [chemical binding]; other site
395491005015	Uncharacterized conserved protein [Function unknown]; Region: COG5397
395491005016	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491005017	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
395491005018	ligand binding site [chemical binding]; other site
395491005019	flexible hinge region; other site
395491005020	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491005021	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
395491005022	SnoaL-like domain; Region: SnoaL_3; pfam13474
395491005023	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
395491005024	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491005025	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
395491005026	Catalytic site [active]
395491005027	GcrA cell cycle regulator; Region: GcrA; cl11564
395491005028	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491005029	DNA binding residues [nucleotide binding]
395491005030	dimerization interface [polypeptide binding]; other site
395491005031	NIPSNAP; Region: NIPSNAP; pfam07978
395491005032	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
395491005033	active site
395491005034	substrate binding site [chemical binding]; other site
395491005035	ATP binding site [chemical binding]; other site
395491005036	Phosphotransferase enzyme family; Region: APH; pfam01636
395491005037	Carboxylesterase family; Region: COesterase; pfam00135
395491005038	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395491005039	substrate binding pocket [chemical binding]; other site
395491005040	catalytic triad [active]
395491005041	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
395491005042	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
395491005043	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491005044	dimer interface [polypeptide binding]; other site
395491005045	phosphorylation site [posttranslational modification]
395491005046	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491005047	ATP binding site [chemical binding]; other site
395491005048	Mg2+ binding site [ion binding]; other site
395491005049	G-X-G motif; other site
395491005050	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
395491005051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491005052	active site
395491005053	phosphorylation site [posttranslational modification]
395491005054	intermolecular recognition site; other site
395491005055	dimerization interface [polypeptide binding]; other site
395491005056	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491005057	DNA binding site [nucleotide binding]
395491005058	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
395491005059	Cytochrome c; Region: Cytochrom_C; cl11414
395491005060	Cytochrome c; Region: Cytochrom_C; cl11414
395491005061	hypothetical protein; Provisional; Region: PRK06486
395491005062	intersubunit interface [polypeptide binding]; other site
395491005063	active site
395491005064	Zn2+ binding site [ion binding]; other site
395491005065	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491005066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491005067	active site
395491005068	phosphorylation site [posttranslational modification]
395491005069	intermolecular recognition site; other site
395491005070	dimerization interface [polypeptide binding]; other site
395491005071	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491005072	PAS domain; Region: PAS_9; pfam13426
395491005073	putative active site [active]
395491005074	heme pocket [chemical binding]; other site
395491005075	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395491005076	Histidine kinase; Region: HisKA_2; pfam07568
395491005077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491005078	ATP binding site [chemical binding]; other site
395491005079	Mg2+ binding site [ion binding]; other site
395491005080	G-X-G motif; other site
395491005081	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
395491005082	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
395491005083	iron-sulfur cluster [ion binding]; other site
395491005084	[2Fe-2S] cluster binding site [ion binding]; other site
395491005085	RibD C-terminal domain; Region: RibD_C; cl17279
395491005086	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
395491005087	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
395491005088	homotrimer interaction site [polypeptide binding]; other site
395491005089	putative active site [active]
395491005090	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491005091	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491005092	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395491005093	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395491005094	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491005095	dimerization interface [polypeptide binding]; other site
395491005096	putative DNA binding site [nucleotide binding]; other site
395491005097	putative Zn2+ binding site [ion binding]; other site
395491005098	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
395491005099	putative hydrophobic ligand binding site [chemical binding]; other site
395491005100	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
395491005101	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
395491005102	oligomer interface [polypeptide binding]; other site
395491005103	active site residues [active]
395491005104	Transglycosylase associated protein; Region: Transgly_assoc; pfam04226
395491005105	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
395491005106	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
395491005107	BON domain; Region: BON; cl02771
395491005108	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395491005109	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395491005110	active site
395491005111	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
395491005112	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
395491005113	nucleoside/Zn binding site; other site
395491005114	dimer interface [polypeptide binding]; other site
395491005115	catalytic motif [active]
395491005116	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
395491005117	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
395491005118	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
395491005119	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
395491005120	putative NAD(P) binding site [chemical binding]; other site
395491005121	putative active site [active]
395491005122	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491005123	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491005124	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
395491005125	dimerization interface [polypeptide binding]; other site
395491005126	substrate binding pocket [chemical binding]; other site
395491005127	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
395491005128	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
395491005129	active site
395491005130	ATP binding site [chemical binding]; other site
395491005131	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491005132	dimerization interface [polypeptide binding]; other site
395491005133	putative DNA binding site [nucleotide binding]; other site
395491005134	putative Zn2+ binding site [ion binding]; other site
395491005135	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395491005136	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
395491005137	NADP binding site [chemical binding]; other site
395491005138	homodimer interface [polypeptide binding]; other site
395491005139	active site
395491005140	substrate binding site [chemical binding]; other site
395491005141	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
395491005142	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491005143	Helix-turn-helix domain; Region: HTH_18; pfam12833
395491005144	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
395491005145	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491005146	NAD(P) binding site [chemical binding]; other site
395491005147	active site
395491005148	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491005149	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
395491005150	C-terminal domain interface [polypeptide binding]; other site
395491005151	GSH binding site (G-site) [chemical binding]; other site
395491005152	dimer interface [polypeptide binding]; other site
395491005153	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
395491005154	N-terminal domain interface [polypeptide binding]; other site
395491005155	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
395491005156	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395491005157	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491005158	Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308
395491005159	BA14K-like protein; Region: BA14K; pfam07886
395491005160	LysR family transcriptional regulator; Provisional; Region: PRK14997
395491005161	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491005162	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491005163	putative effector binding pocket; other site
395491005164	dimerization interface [polypeptide binding]; other site
395491005165	NmrA-like family; Region: NmrA; pfam05368
395491005166	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
395491005167	NADP binding site [chemical binding]; other site
395491005168	active site
395491005169	regulatory binding site [polypeptide binding]; other site
395491005170	DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863
395491005171	putative hydrophobic ligand binding site [chemical binding]; other site
395491005172	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
395491005173	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
395491005174	potential catalytic triad [active]
395491005175	conserved cys residue [active]
395491005176	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
395491005177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491005178	The C-terminal substrate binding of LysR-type symbiotic regulator SyrM, which activates expression of nodulation gene NodD3, contains the type 2 periplasmic binding fold; Region: PBP2_SyrM; cd08467
395491005179	putative substrate binding pocket [chemical binding]; other site
395491005180	putative dimerization interface [polypeptide binding]; other site
395491005181	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
395491005182	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491005183	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491005184	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395491005185	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395491005186	N-terminal domain interface [polypeptide binding]; other site
395491005187	dimer interface [polypeptide binding]; other site
395491005188	substrate binding pocket (H-site) [chemical binding]; other site
395491005189	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
395491005190	putative hydrophobic ligand binding site [chemical binding]; other site
395491005191	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491005192	dimerization interface [polypeptide binding]; other site
395491005193	putative DNA binding site [nucleotide binding]; other site
395491005194	putative Zn2+ binding site [ion binding]; other site
395491005195	DoxX-like family; Region: DoxX_2; pfam13564
395491005196	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
395491005197	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491005198	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491005199	WHG domain; Region: WHG; pfam13305
395491005200	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491005201	dimerization interface [polypeptide binding]; other site
395491005202	putative DNA binding site [nucleotide binding]; other site
395491005203	putative Zn2+ binding site [ion binding]; other site
395491005204	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
395491005205	putative hydrophobic ligand binding site [chemical binding]; other site
395491005206	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
395491005207	active site
395491005208	ATP binding site [chemical binding]; other site
395491005209	substrate binding site [chemical binding]; other site
395491005210	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491005211	cyclase homology domain; Region: CHD; cd07302
395491005212	nucleotidyl binding site; other site
395491005213	metal binding site [ion binding]; metal-binding site
395491005214	dimer interface [polypeptide binding]; other site
395491005215	Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549
395491005216	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
395491005217	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491005218	non-specific DNA binding site [nucleotide binding]; other site
395491005219	salt bridge; other site
395491005220	sequence-specific DNA binding site [nucleotide binding]; other site
395491005221	Short repeat of unknown function (DUF308); Region: DUF308; pfam03729
395491005222	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491005223	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491005224	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
395491005225	short chain dehydrogenase; Provisional; Region: PRK06180
395491005226	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395491005227	NADP binding site [chemical binding]; other site
395491005228	active site
395491005229	steroid binding site; other site
395491005230	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
395491005231	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491005232	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491005233	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491005234	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
395491005235	putative dimer interface [polypeptide binding]; other site
395491005236	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491005237	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
395491005238	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
395491005239	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
395491005240	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395491005241	large terminase protein; Provisional; Region: 17; PHA02533
395491005242	Uncharacterized protein conserved in archaea (DUF2286); Region: DUF2286; cl02234
395491005243	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
395491005244	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
395491005245	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
395491005246	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395491005247	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395491005248	protein binding site [polypeptide binding]; other site
395491005249	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395491005250	protein binding site [polypeptide binding]; other site
395491005251	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491005252	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491005253	DNA binding site [nucleotide binding]
395491005254	domain linker motif; other site
395491005255	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
395491005256	putative ligand binding site [chemical binding]; other site
395491005257	putative dimerization interface [polypeptide binding]; other site
395491005258	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491005259	LysR family transcriptional regulator; Provisional; Region: PRK14997
395491005260	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491005261	putative effector binding pocket; other site
395491005262	dimerization interface [polypeptide binding]; other site
395491005263	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
395491005264	NmrA-like family; Region: NmrA; pfam05368
395491005265	NADP binding site [chemical binding]; other site
395491005266	active site
395491005267	regulatory binding site [polypeptide binding]; other site
395491005268	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
395491005269	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
395491005270	NADP binding site [chemical binding]; other site
395491005271	dimer interface [polypeptide binding]; other site
395491005272	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491005273	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491005274	LysR substrate binding domain; Region: LysR_substrate; pfam03466
395491005275	dimerization interface [polypeptide binding]; other site
395491005276	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491005277	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491005278	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
395491005279	putative catalytic residues [active]
395491005280	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
395491005281	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
395491005282	CysD dimerization site [polypeptide binding]; other site
395491005283	G1 box; other site
395491005284	putative GEF interaction site [polypeptide binding]; other site
395491005285	GTP/Mg2+ binding site [chemical binding]; other site
395491005286	Switch I region; other site
395491005287	G2 box; other site
395491005288	G3 box; other site
395491005289	Switch II region; other site
395491005290	G4 box; other site
395491005291	G5 box; other site
395491005292	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
395491005293	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
395491005294	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
395491005295	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
395491005296	Active Sites [active]
395491005297	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
395491005298	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
395491005299	Active Sites [active]
395491005300	Predicted transcriptional regulator [Transcription]; Region: COG1959
395491005301	Transcriptional regulator; Region: Rrf2; pfam02082
395491005302	MarR family; Region: MarR_2; pfam12802
395491005303	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395491005304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491005305	NAD(P) binding site [chemical binding]; other site
395491005306	active site
395491005307	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
395491005308	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
395491005309	active site
395491005310	FMN binding site [chemical binding]; other site
395491005311	substrate binding site [chemical binding]; other site
395491005312	homotetramer interface [polypeptide binding]; other site
395491005313	catalytic residue [active]
395491005314	choline dehydrogenase; Validated; Region: PRK02106
395491005315	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395491005316	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395491005317	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
395491005318	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
395491005319	NAD(P) binding site [chemical binding]; other site
395491005320	catalytic residues [active]
395491005321	transcriptional regulator BetI; Validated; Region: PRK00767
395491005322	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491005323	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
395491005324	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
395491005325	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
395491005326	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
395491005327	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
395491005328	NAD(P) binding site [chemical binding]; other site
395491005329	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491005330	putative substrate translocation pore; other site
395491005331	Predicted transcriptional regulator [Transcription]; Region: COG2345
395491005332	MarR family; Region: MarR_2; cl17246
395491005333	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491005334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491005335	putative substrate translocation pore; other site
395491005336	L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448
395491005337	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
395491005338	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
395491005339	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
395491005340	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198
395491005341	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491005342	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
395491005343	C-terminal domain interface [polypeptide binding]; other site
395491005344	GSH binding site (G-site) [chemical binding]; other site
395491005345	dimer interface [polypeptide binding]; other site
395491005346	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
395491005347	dimer interface [polypeptide binding]; other site
395491005348	N-terminal domain interface [polypeptide binding]; other site
395491005349	substrate binding pocket (H-site) [chemical binding]; other site
395491005350	Protein of unknown function (DUF419); Region: DUF419; cl15265
395491005351	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491005352	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491005353	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
395491005354	dimerization interface [polypeptide binding]; other site
395491005355	substrate binding pocket [chemical binding]; other site
395491005356	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491005357	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
395491005358	putative C-terminal domain interface [polypeptide binding]; other site
395491005359	putative GSH binding site (G-site) [chemical binding]; other site
395491005360	putative dimer interface [polypeptide binding]; other site
395491005361	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
395491005362	dimer interface [polypeptide binding]; other site
395491005363	N-terminal domain interface [polypeptide binding]; other site
395491005364	putative substrate binding pocket (H-site) [chemical binding]; other site
395491005365	twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808
395491005366	PAS fold; Region: PAS_4; pfam08448
395491005367	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491005368	putative active site [active]
395491005369	heme pocket [chemical binding]; other site
395491005370	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395491005371	GAF domain; Region: GAF; pfam01590
395491005372	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491005373	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491005374	metal binding site [ion binding]; metal-binding site
395491005375	active site
395491005376	I-site; other site
395491005377	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491005378	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial  homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613
395491005379	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
395491005380	putative active site [active]
395491005381	catalytic site [active]
395491005382	putative metal binding site [ion binding]; other site
395491005383	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491005384	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491005385	TPR motif; other site
395491005386	binding surface
395491005387	TPR repeat; Region: TPR_11; pfam13414
395491005388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395491005389	S-adenosylmethionine binding site [chemical binding]; other site
395491005390	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
395491005391	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395491005392	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
395491005393	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
395491005394	active site
395491005395	DNA binding site [nucleotide binding]
395491005396	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
395491005397	DNA binding site [nucleotide binding]
395491005398	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395491005399	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
395491005400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395491005401	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491005402	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395491005403	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491005404	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395491005405	DNA-binding site [nucleotide binding]; DNA binding site
395491005406	RNA-binding motif; other site
395491005407	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
395491005408	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491005409	MarR family; Region: MarR; pfam01047
395491005410	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
395491005411	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395491005412	MarR family; Region: MarR_2; pfam12802
395491005413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312
395491005414	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
395491005415	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491005416	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
395491005417	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491005418	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
395491005419	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
395491005420	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
395491005421	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395491005422	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395491005423	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
395491005424	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
395491005425	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491005426	Walker A/P-loop; other site
395491005427	ATP binding site [chemical binding]; other site
395491005428	Q-loop/lid; other site
395491005429	ABC transporter signature motif; other site
395491005430	Walker B; other site
395491005431	D-loop; other site
395491005432	H-loop/switch region; other site
395491005433	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395491005434	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
395491005435	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
395491005436	nudix motif; other site
395491005437	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
395491005438	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
395491005439	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
395491005440	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
395491005441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491005442	S-adenosylmethionine binding site [chemical binding]; other site
395491005443	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
395491005444	Domain of unknown function DUF21; Region: DUF21; pfam01595
395491005445	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
395491005446	Transporter associated domain; Region: CorC_HlyC; smart01091
395491005447	Cache domain; Region: Cache_1; pfam02743
395491005448	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491005449	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491005450	dimer interface [polypeptide binding]; other site
395491005451	putative CheW interface [polypeptide binding]; other site
395491005452	topology modulation protein; Reviewed; Region: PRK08118
395491005453	AAA domain; Region: AAA_17; pfam13207
395491005454	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491005455	Coenzyme A binding pocket [chemical binding]; other site
395491005456	Predicted kinase [General function prediction only]; Region: COG0645
395491005457	AAA domain; Region: AAA_17; pfam13207
395491005458	Cupin domain; Region: Cupin_2; pfam07883
395491005459	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
395491005460	Metal-binding active site; metal-binding site
395491005461	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
395491005462	AP (apurinic/apyrimidinic) site pocket; other site
395491005463	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
395491005464	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260
395491005465	putative NAD(P) binding site [chemical binding]; other site
395491005466	catalytic Zn binding site [ion binding]; other site
395491005467	structural Zn binding site [ion binding]; other site
395491005468	aminotransferase; Provisional; Region: PRK13356
395491005469	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
395491005470	homodimer interface [polypeptide binding]; other site
395491005471	substrate-cofactor binding pocket; other site
395491005472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491005473	catalytic residue [active]
395491005474	transcriptional regulator; Provisional; Region: PRK10632
395491005475	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491005476	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491005477	putative effector binding pocket; other site
395491005478	dimerization interface [polypeptide binding]; other site
395491005479	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
395491005480	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491005481	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491005482	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
395491005483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491005484	putative substrate translocation pore; other site
395491005485	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491005486	cyclase homology domain; Region: CHD; cd07302
395491005487	nucleotidyl binding site; other site
395491005488	metal binding site [ion binding]; metal-binding site
395491005489	dimer interface [polypeptide binding]; other site
395491005490	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
395491005491	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
395491005492	homodimer interface [polypeptide binding]; other site
395491005493	NAD binding pocket [chemical binding]; other site
395491005494	ATP binding pocket [chemical binding]; other site
395491005495	Mg binding site [ion binding]; other site
395491005496	active-site loop [active]
395491005497	glutathionine S-transferase; Provisional; Region: PRK10542
395491005498	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
395491005499	C-terminal domain interface [polypeptide binding]; other site
395491005500	GSH binding site (G-site) [chemical binding]; other site
395491005501	dimer interface [polypeptide binding]; other site
395491005502	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
395491005503	N-terminal domain interface [polypeptide binding]; other site
395491005504	dimer interface [polypeptide binding]; other site
395491005505	substrate binding pocket (H-site) [chemical binding]; other site
395491005506	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491005507	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491005508	drug efflux system protein MdtG; Provisional; Region: PRK09874
395491005509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491005510	putative substrate translocation pore; other site
395491005511	SnoaL-like domain; Region: SnoaL_2; pfam12680
395491005512	Predicted permeases [General function prediction only]; Region: COG0730
395491005513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491005514	S-adenosylmethionine binding site [chemical binding]; other site
395491005515	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
395491005516	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
395491005517	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
395491005518	Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396
395491005519	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395491005520	active site
395491005521	metal binding site [ion binding]; metal-binding site
395491005522	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
395491005523	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491005524	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395491005525	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491005526	NAD(P) binding site [chemical binding]; other site
395491005527	active site
395491005528	Predicted transcriptional regulator [Transcription]; Region: COG2378
395491005529	HTH domain; Region: HTH_11; pfam08279
395491005530	WYL domain; Region: WYL; pfam13280
395491005531	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
395491005532	Cytochrome C' Region: Cytochrom_C_2; cl01610
395491005533	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395491005534	Cytochrome c; Region: Cytochrom_C; pfam00034
395491005535	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491005536	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
395491005537	putative C-terminal domain interface [polypeptide binding]; other site
395491005538	putative GSH binding site (G-site) [chemical binding]; other site
395491005539	putative dimer interface [polypeptide binding]; other site
395491005540	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395491005541	N-terminal domain interface [polypeptide binding]; other site
395491005542	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491005543	Coenzyme A binding pocket [chemical binding]; other site
395491005544	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
395491005545	putative metal binding site [ion binding]; other site
395491005546	putative homodimer interface [polypeptide binding]; other site
395491005547	putative homotetramer interface [polypeptide binding]; other site
395491005548	putative homodimer-homodimer interface [polypeptide binding]; other site
395491005549	putative allosteric switch controlling residues; other site
395491005550	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
395491005551	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
395491005552	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
395491005553	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
395491005554	Trp docking motif [polypeptide binding]; other site
395491005555	putative active site [active]
395491005556	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395491005557	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491005558	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491005559	Walker A/P-loop; other site
395491005560	ATP binding site [chemical binding]; other site
395491005561	Q-loop/lid; other site
395491005562	ABC transporter signature motif; other site
395491005563	Walker B; other site
395491005564	D-loop; other site
395491005565	H-loop/switch region; other site
395491005566	hypothetical protein; Validated; Region: PRK00029
395491005567	Uncharacterized conserved protein [Function unknown]; Region: COG0397
395491005568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491005569	putative substrate translocation pore; other site
395491005570	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
395491005571	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
395491005572	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491005573	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491005574	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
395491005575	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
395491005576	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395491005577	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
395491005578	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
395491005579	Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955
395491005580	NodB motif; other site
395491005581	putative active site [active]
395491005582	putative catalytic site [active]
395491005583	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
395491005584	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491005585	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395491005586	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395491005587	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
395491005588	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
395491005589	putative metal binding site [ion binding]; other site
395491005590	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395491005591	active site
395491005592	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395491005593	Ligand Binding Site [chemical binding]; other site
395491005594	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
395491005595	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
395491005596	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
395491005597	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491005598	Coenzyme A binding pocket [chemical binding]; other site
395491005599	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395491005600	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395491005601	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395491005602	methionine sulfoxide reductase B; Provisional; Region: PRK00222
395491005603	SelR domain; Region: SelR; pfam01641
395491005604	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
395491005605	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395491005606	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
395491005607	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
395491005608	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658
395491005609	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
395491005610	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395491005611	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
395491005612	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
395491005613	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
395491005614	Predicted transcriptional regulator [Transcription]; Region: COG4957
395491005615	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
395491005616	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491005617	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491005618	dimer interface [polypeptide binding]; other site
395491005619	phosphorylation site [posttranslational modification]
395491005620	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491005621	ATP binding site [chemical binding]; other site
395491005622	Mg2+ binding site [ion binding]; other site
395491005623	G-X-G motif; other site
395491005624	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
395491005625	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491005626	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491005627	Cupin; Region: Cupin_6; pfam12852
395491005628	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491005629	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491005630	oxidoreductase; Provisional; Region: PRK06196
395491005631	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
395491005632	putative NAD(P) binding site [chemical binding]; other site
395491005633	active site
395491005634	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491005635	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491005636	dimer interface [polypeptide binding]; other site
395491005637	putative CheW interface [polypeptide binding]; other site
395491005638	Protein of unknown function (DUF1491); Region: DUF1491; cl11568
395491005639	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
395491005640	Predicted integral membrane protein [Function unknown]; Region: COG5436
395491005641	Uncharacterized conserved protein [Function unknown]; Region: COG5402
395491005642	Transglycosylase; Region: Transgly; pfam00912
395491005643	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
395491005644	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395491005645	hypothetical protein; Provisional; Region: PRK05170
395491005646	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
395491005647	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
395491005648	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491005649	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491005650	short chain dehydrogenase; Provisional; Region: PRK08303
395491005651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491005652	NAD(P) binding site [chemical binding]; other site
395491005653	active site
395491005654	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
395491005655	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
395491005656	putative di-iron ligands [ion binding]; other site
395491005657	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491005658	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491005659	putative substrate translocation pore; other site
395491005660	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491005661	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491005662	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491005663	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
395491005664	putative substrate binding pocket [chemical binding]; other site
395491005665	putative dimerization interface [polypeptide binding]; other site
395491005666	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
395491005667	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395491005668	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395491005669	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
395491005670	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
395491005671	oligomerisation interface [polypeptide binding]; other site
395491005672	mobile loop; other site
395491005673	roof hairpin; other site
395491005674	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
395491005675	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
395491005676	ring oligomerisation interface [polypeptide binding]; other site
395491005677	ATP/Mg binding site [chemical binding]; other site
395491005678	stacking interactions; other site
395491005679	hinge regions; other site
395491005680	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491005681	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491005682	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491005683	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491005684	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491005685	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491005686	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491005687	DNA binding site [nucleotide binding]
395491005688	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
395491005689	putative ligand binding site [chemical binding]; other site
395491005690	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395491005691	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395491005692	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395491005693	protein binding site [polypeptide binding]; other site
395491005694	Cupin; Region: Cupin_6; pfam12852
395491005695	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491005696	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491005697	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491005698	oxidoreductase; Provisional; Region: PRK06196
395491005699	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
395491005700	putative NAD(P) binding site [chemical binding]; other site
395491005701	active site
395491005702	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
395491005703	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491005704	DNA-binding site [nucleotide binding]; DNA binding site
395491005705	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491005706	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491005707	homodimer interface [polypeptide binding]; other site
395491005708	catalytic residue [active]
395491005709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
395491005710	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491005711	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491005712	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
395491005713	putative effector binding pocket; other site
395491005714	putative dimerization interface [polypeptide binding]; other site
395491005715	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491005716	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
395491005717	putative C-terminal domain interface [polypeptide binding]; other site
395491005718	putative GSH binding site (G-site) [chemical binding]; other site
395491005719	putative dimer interface [polypeptide binding]; other site
395491005720	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
395491005721	putative N-terminal domain interface [polypeptide binding]; other site
395491005722	putative dimer interface [polypeptide binding]; other site
395491005723	putative substrate binding pocket (H-site) [chemical binding]; other site
395491005724	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
395491005725	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
395491005726	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
395491005727	SnoaL-like domain; Region: SnoaL_2; pfam12680
395491005728	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491005729	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491005730	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
395491005731	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
395491005732	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491005733	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491005734	putative substrate translocation pore; other site
395491005735	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491005736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491005737	active site
395491005738	phosphorylation site [posttranslational modification]
395491005739	intermolecular recognition site; other site
395491005740	dimerization interface [polypeptide binding]; other site
395491005741	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491005742	DNA binding site [nucleotide binding]
395491005743	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491005744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491005745	ATP binding site [chemical binding]; other site
395491005746	Mg2+ binding site [ion binding]; other site
395491005747	G-X-G motif; other site
395491005748	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
395491005749	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
395491005750	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
395491005751	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491005752	TPR motif; other site
395491005753	binding surface
395491005754	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
395491005755	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
395491005756	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
395491005757	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
395491005758	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395491005759	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395491005760	protein binding site [polypeptide binding]; other site
395491005761	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395491005762	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491005763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491005764	active site
395491005765	phosphorylation site [posttranslational modification]
395491005766	intermolecular recognition site; other site
395491005767	dimerization interface [polypeptide binding]; other site
395491005768	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491005769	DNA binding site [nucleotide binding]
395491005770	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491005771	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491005772	dimerization interface [polypeptide binding]; other site
395491005773	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491005774	dimer interface [polypeptide binding]; other site
395491005775	phosphorylation site [posttranslational modification]
395491005776	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491005777	ATP binding site [chemical binding]; other site
395491005778	Mg2+ binding site [ion binding]; other site
395491005779	G-X-G motif; other site
395491005780	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
395491005781	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
395491005782	metal binding triad; other site
395491005783	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
395491005784	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
395491005785	metal binding triad; other site
395491005786	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
395491005787	putative C-terminal domain interface [polypeptide binding]; other site
395491005788	putative GSH binding site (G-site) [chemical binding]; other site
395491005789	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491005790	putative dimer interface [polypeptide binding]; other site
395491005791	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
395491005792	dimer interface [polypeptide binding]; other site
395491005793	N-terminal domain interface [polypeptide binding]; other site
395491005794	putative substrate binding pocket (H-site) [chemical binding]; other site
395491005795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491005796	PAS fold; Region: PAS_3; pfam08447
395491005797	putative active site [active]
395491005798	heme pocket [chemical binding]; other site
395491005799	PAS fold; Region: PAS_7; pfam12860
395491005800	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491005801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491005802	dimer interface [polypeptide binding]; other site
395491005803	phosphorylation site [posttranslational modification]
395491005804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491005805	ATP binding site [chemical binding]; other site
395491005806	Mg2+ binding site [ion binding]; other site
395491005807	G-X-G motif; other site
395491005808	aminopeptidase N; Provisional; Region: pepN; PRK14015
395491005809	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
395491005810	active site
395491005811	Zn binding site [ion binding]; other site
395491005812	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395491005813	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491005814	putative CheW interface [polypeptide binding]; other site
395491005815	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395491005816	EamA-like transporter family; Region: EamA; pfam00892
395491005817	EamA-like transporter family; Region: EamA; pfam00892
395491005818	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
395491005819	Fe-S cluster binding site [ion binding]; other site
395491005820	active site
395491005821	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
395491005822	putative chaperone; Provisional; Region: PRK11678
395491005823	nucleotide binding site [chemical binding]; other site
395491005824	putative NEF/HSP70 interaction site [polypeptide binding]; other site
395491005825	SBD interface [polypeptide binding]; other site
395491005826	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395491005827	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395491005828	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491005829	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491005830	Phosphotransferase enzyme family; Region: APH; pfam01636
395491005831	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
395491005832	active site
395491005833	ATP binding site [chemical binding]; other site
395491005834	short chain dehydrogenase; Provisional; Region: PRK08339
395491005835	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
395491005836	putative NAD(P) binding site [chemical binding]; other site
395491005837	putative active site [active]
395491005838	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
395491005839	hydroxyglutarate oxidase; Provisional; Region: PRK11728
395491005840	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
395491005841	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395491005842	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491005843	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491005844	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491005845	dimerization interface [polypeptide binding]; other site
395491005846	putative DNA binding site [nucleotide binding]; other site
395491005847	putative Zn2+ binding site [ion binding]; other site
395491005848	AsnC family; Region: AsnC_trans_reg; pfam01037
395491005849	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
395491005850	MgtE intracellular N domain; Region: MgtE_N; pfam03448
395491005851	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
395491005852	Divalent cation transporter; Region: MgtE; pfam01769
395491005853	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
395491005854	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
395491005855	putative NAD(P) binding site [chemical binding]; other site
395491005856	dimer interface [polypeptide binding]; other site
395491005857	Predicted transcriptional regulators [Transcription]; Region: COG1733
395491005858	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395491005859	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
395491005860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491005861	putative substrate translocation pore; other site
395491005862	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
395491005863	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
395491005864	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
395491005865	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395491005866	putative aminotransferase; Validated; Region: PRK07480
395491005867	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395491005868	inhibitor-cofactor binding pocket; inhibition site
395491005869	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491005870	catalytic residue [active]
395491005871	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
395491005872	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
395491005873	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
395491005874	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
395491005875	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
395491005876	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
395491005877	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
395491005878	Ligand binding site; other site
395491005879	Putative Catalytic site; other site
395491005880	DXD motif; other site
395491005881	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
395491005882	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
395491005883	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491005884	DNA binding residues [nucleotide binding]
395491005885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
395491005886	YCII-related domain; Region: YCII; cl00999
395491005887	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
395491005888	AMP nucleosidase; Provisional; Region: PRK08292
395491005889	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
395491005890	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
395491005891	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
395491005892	Predicted transcriptional regulator [Transcription]; Region: COG3905
395491005893	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
395491005894	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395491005895	Sel1 repeat; Region: Sel1; cl02723
395491005896	histidinol-phosphate aminotransferase; Provisional; Region: PRK08153
395491005897	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491005898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491005899	homodimer interface [polypeptide binding]; other site
395491005900	catalytic residue [active]
395491005901	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
395491005902	Protein required for attachment to host cells; Region: Host_attach; pfam10116
395491005903	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491005904	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491005905	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491005906	replicative DNA helicase; Provisional; Region: PRK05973
395491005907	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
395491005908	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
395491005909	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395491005910	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491005911	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
395491005912	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
395491005913	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491005914	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
395491005915	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
395491005916	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395491005917	dimer interface [polypeptide binding]; other site
395491005918	PYR/PP interface [polypeptide binding]; other site
395491005919	TPP binding site [chemical binding]; other site
395491005920	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395491005921	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
395491005922	TPP-binding site; other site
395491005923	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491005924	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
395491005925	substrate binding site [chemical binding]; other site
395491005926	ATP binding site [chemical binding]; other site
395491005927	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
395491005928	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
395491005929	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
395491005930	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
395491005931	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
395491005932	putative active site [active]
395491005933	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491005934	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491005935	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491005936	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
395491005937	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395491005938	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395491005939	Porin subfamily; Region: Porin_2; pfam02530
395491005940	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491005941	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395491005942	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395491005943	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395491005944	catalytic residue [active]
395491005945	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491005946	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
395491005947	dimer interface [polypeptide binding]; other site
395491005948	active site
395491005949	catalytic residue [active]
395491005950	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
395491005951	SmpB-tmRNA interface; other site
395491005952	Uncharacterized conserved protein [Function unknown]; Region: COG1432
395491005953	LabA_like proteins; Region: LabA; cd10911
395491005954	putative metal binding site [ion binding]; other site
395491005955	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
395491005956	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
395491005957	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395491005958	Zn2+ binding site [ion binding]; other site
395491005959	Mg2+ binding site [ion binding]; other site
395491005960	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
395491005961	synthetase active site [active]
395491005962	NTP binding site [chemical binding]; other site
395491005963	metal binding site [ion binding]; metal-binding site
395491005964	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
395491005965	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
395491005966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216
395491005967	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
395491005968	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
395491005969	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
395491005970	Catalytic site [active]
395491005971	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
395491005972	ribonuclease III; Reviewed; Region: PRK12371
395491005973	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
395491005974	dimerization interface [polypeptide binding]; other site
395491005975	active site
395491005976	metal binding site [ion binding]; metal-binding site
395491005977	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
395491005978	dsRNA binding site [nucleotide binding]; other site
395491005979	GTPase Era; Reviewed; Region: era; PRK00089
395491005980	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
395491005981	G1 box; other site
395491005982	GTP/Mg2+ binding site [chemical binding]; other site
395491005983	Switch I region; other site
395491005984	G2 box; other site
395491005985	Switch II region; other site
395491005986	G3 box; other site
395491005987	G4 box; other site
395491005988	G5 box; other site
395491005989	KH domain; Region: KH_2; pfam07650
395491005990	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491005991	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491005992	ligand binding site [chemical binding]; other site
395491005993	flexible hinge region; other site
395491005994	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395491005995	putative switch regulator; other site
395491005996	non-specific DNA interactions [nucleotide binding]; other site
395491005997	DNA binding site [nucleotide binding]
395491005998	sequence specific DNA binding site [nucleotide binding]; other site
395491005999	putative cAMP binding site [chemical binding]; other site
395491006000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491006001	active site
395491006002	phosphorylation site [posttranslational modification]
395491006003	intermolecular recognition site; other site
395491006004	dimerization interface [polypeptide binding]; other site
395491006005	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
395491006006	Recombination protein O N terminal; Region: RecO_N; pfam11967
395491006007	Recombination protein O C terminal; Region: RecO_C; pfam02565
395491006008	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491006009	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491006010	active site
395491006011	catalytic tetrad [active]
395491006012	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
395491006013	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
395491006014	MOSC domain; Region: MOSC; pfam03473
395491006015	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
395491006016	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
395491006017	PAS domain; Region: PAS; smart00091
395491006018	PAS fold; Region: PAS_7; pfam12860
395491006019	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491006020	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491006021	metal binding site [ion binding]; metal-binding site
395491006022	active site
395491006023	I-site; other site
395491006024	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491006025	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
395491006026	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
395491006027	E-class dimer interface [polypeptide binding]; other site
395491006028	P-class dimer interface [polypeptide binding]; other site
395491006029	active site
395491006030	Cu2+ binding site [ion binding]; other site
395491006031	Zn2+ binding site [ion binding]; other site
395491006032	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395491006033	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
395491006034	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
395491006035	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
395491006036	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
395491006037	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395491006038	Protein of unknown function (DUF2385); Region: DUF2385; pfam09539
395491006039	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
395491006040	nudix motif; other site
395491006041	Uncharacterized conserved protein [Function unknown]; Region: COG1742
395491006042	Uncharacterized conserved protein [Function unknown]; Region: COG2135
395491006043	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
395491006044	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
395491006045	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
395491006046	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
395491006047	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491006048	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
395491006049	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
395491006050	Walker A/P-loop; other site
395491006051	ATP binding site [chemical binding]; other site
395491006052	Q-loop/lid; other site
395491006053	ABC transporter signature motif; other site
395491006054	Walker B; other site
395491006055	D-loop; other site
395491006056	H-loop/switch region; other site
395491006057	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
395491006058	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
395491006059	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
395491006060	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
395491006061	Predicted permeases [General function prediction only]; Region: RarD; COG2962
395491006062	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
395491006063	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
395491006064	active site
395491006065	catalytic residues [active]
395491006066	metal binding site [ion binding]; metal-binding site
395491006067	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
395491006068	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
395491006069	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491006070	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491006071	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491006072	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
395491006073	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
395491006074	active site
395491006075	HIGH motif; other site
395491006076	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
395491006077	KMSKS motif; other site
395491006078	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
395491006079	tRNA binding surface [nucleotide binding]; other site
395491006080	anticodon binding site; other site
395491006081	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
395491006082	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
395491006083	active site
395491006084	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491006085	classical (c) SDRs; Region: SDR_c; cd05233
395491006086	NAD(P) binding site [chemical binding]; other site
395491006087	active site
395491006088	amidophosphoribosyltransferase; Provisional; Region: PRK09123
395491006089	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
395491006090	active site
395491006091	tetramer interface [polypeptide binding]; other site
395491006092	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395491006093	active site
395491006094	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
395491006095	Colicin V production protein; Region: Colicin_V; pfam02674
395491006096	DNA repair protein RadA; Provisional; Region: PRK11823
395491006097	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395491006098	Walker A motif; other site
395491006099	ATP binding site [chemical binding]; other site
395491006100	Walker B motif; other site
395491006101	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
395491006102	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
395491006103	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
395491006104	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
395491006105	active site
395491006106	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395491006107	dimer interface [polypeptide binding]; other site
395491006108	substrate binding site [chemical binding]; other site
395491006109	catalytic residues [active]
395491006110	replicative DNA helicase; Provisional; Region: PRK09165
395491006111	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
395491006112	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
395491006113	Walker A motif; other site
395491006114	ATP binding site [chemical binding]; other site
395491006115	Walker B motif; other site
395491006116	DNA binding loops [nucleotide binding]
395491006117	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
395491006118	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
395491006119	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
395491006120	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
395491006121	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
395491006122	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491006123	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491006124	active site
395491006125	catalytic tetrad [active]
395491006126	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
395491006127	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
395491006128	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
395491006129	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
395491006130	NAD(P) binding site [chemical binding]; other site
395491006131	homotetramer interface [polypeptide binding]; other site
395491006132	homodimer interface [polypeptide binding]; other site
395491006133	active site
395491006134	acyl carrier protein; Provisional; Region: acpP; PRK00982
395491006135	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
395491006136	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395491006137	dimer interface [polypeptide binding]; other site
395491006138	active site
395491006139	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
395491006140	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
395491006141	dimerization interface [polypeptide binding]; other site
395491006142	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
395491006143	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
395491006144	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
395491006145	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
395491006146	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
395491006147	catalytic site [active]
395491006148	G-X2-G-X-G-K; other site
395491006149	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
395491006150	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491006151	S-adenosylmethionine binding site [chemical binding]; other site
395491006152	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
395491006153	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
395491006154	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
395491006155	SurA N-terminal domain; Region: SurA_N; pfam09312
395491006156	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
395491006157	Organic solvent tolerance protein; Region: OstA_C; pfam04453
395491006158	Predicted permeases [General function prediction only]; Region: COG0795
395491006159	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
395491006160	Predicted permeases [General function prediction only]; Region: COG0795
395491006161	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
395491006162	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
395491006163	active site
395491006164	multifunctional aminopeptidase A; Provisional; Region: PRK00913
395491006165	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
395491006166	interface (dimer of trimers) [polypeptide binding]; other site
395491006167	Substrate-binding/catalytic site; other site
395491006168	Zn-binding sites [ion binding]; other site
395491006169	DNA polymerase III subunit chi; Validated; Region: PRK05728
395491006170	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491006171	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491006172	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
395491006173	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395491006174	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
395491006175	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
395491006176	NodB motif; other site
395491006177	active site
395491006178	catalytic site [active]
395491006179	metal binding site [ion binding]; metal-binding site
395491006180	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
395491006181	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395491006182	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395491006183	ABC transporter; Region: ABC_tran_2; pfam12848
395491006184	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395491006185	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491006186	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491006187	metal binding site [ion binding]; metal-binding site
395491006188	active site
395491006189	I-site; other site
395491006190	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
395491006191	DinB superfamily; Region: DinB_2; pfam12867
395491006192	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
395491006193	glutaredoxin 2; Provisional; Region: PRK10387
395491006194	putative C-terminal domain interface [polypeptide binding]; other site
395491006195	putative GSH binding site (G-site) [chemical binding]; other site
395491006196	putative dimer interface [polypeptide binding]; other site
395491006197	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
395491006198	putative N-terminal domain interface [polypeptide binding]; other site
395491006199	putative dimer interface [polypeptide binding]; other site
395491006200	putative substrate binding pocket (H-site) [chemical binding]; other site
395491006201	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
395491006202	active site
395491006203	multimer interface [polypeptide binding]; other site
395491006204	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
395491006205	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
395491006206	CGNR zinc finger; Region: zf-CGNR; pfam11706
395491006207	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395491006208	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491006209	TM-ABC transporter signature motif; other site
395491006210	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
395491006211	MoaE homodimer interface [polypeptide binding]; other site
395491006212	MoaD interaction [polypeptide binding]; other site
395491006213	active site residues [active]
395491006214	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
395491006215	MoaE interaction surface [polypeptide binding]; other site
395491006216	MoeB interaction surface [polypeptide binding]; other site
395491006217	thiocarboxylated glycine; other site
395491006218	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
395491006219	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
395491006220	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
395491006221	GIY-YIG motif/motif A; other site
395491006222	active site
395491006223	catalytic site [active]
395491006224	putative DNA binding site [nucleotide binding]; other site
395491006225	metal binding site [ion binding]; metal-binding site
395491006226	UvrB/uvrC motif; Region: UVR; pfam02151
395491006227	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
395491006228	short chain dehydrogenase; Provisional; Region: PRK09134
395491006229	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491006230	NAD(P) binding site [chemical binding]; other site
395491006231	active site
395491006232	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
395491006233	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
395491006234	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
395491006235	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
395491006236	putative [4Fe-4S] binding site [ion binding]; other site
395491006237	putative molybdopterin cofactor binding site [chemical binding]; other site
395491006238	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
395491006239	putative molybdopterin cofactor binding site; other site
395491006240	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
395491006241	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
395491006242	dimer interface [polypeptide binding]; other site
395491006243	ADP-ribose binding site [chemical binding]; other site
395491006244	active site
395491006245	nudix motif; other site
395491006246	metal binding site [ion binding]; metal-binding site
395491006247	phosphonate metabolism protein PhnM; Region: phosphono_phnM; TIGR02318
395491006248	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491006249	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491006250	active site
395491006251	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
395491006252	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
395491006253	active site
395491006254	substrate binding site [chemical binding]; other site
395491006255	cosubstrate binding site; other site
395491006256	catalytic site [active]
395491006257	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
395491006258	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
395491006259	dimerization interface [polypeptide binding]; other site
395491006260	putative ATP binding site [chemical binding]; other site
395491006261	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395491006262	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395491006263	hypothetical protein; Validated; Region: PRK09087
395491006264	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
395491006265	polyphosphate kinase; Provisional; Region: PRK05443
395491006266	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
395491006267	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
395491006268	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
395491006269	putative domain interface [polypeptide binding]; other site
395491006270	putative active site [active]
395491006271	catalytic site [active]
395491006272	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
395491006273	putative domain interface [polypeptide binding]; other site
395491006274	putative active site [active]
395491006275	catalytic site [active]
395491006276	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
395491006277	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
395491006278	Helix-turn-helix domain; Region: HTH_28; pfam13518
395491006279	Winged helix-turn helix; Region: HTH_29; pfam13551
395491006280	Homeodomain-like domain; Region: HTH_32; pfam13565
395491006281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
395491006282	Integrase core domain; Region: rve; pfam00665
395491006283	Integrase core domain; Region: rve_3; pfam13683
395491006284	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
395491006285	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491006286	cyclase homology domain; Region: CHD; cd07302
395491006287	nucleotidyl binding site; other site
395491006288	metal binding site [ion binding]; metal-binding site
395491006289	dimer interface [polypeptide binding]; other site
395491006290	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
395491006291	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
395491006292	catalytic site [active]
395491006293	putative active site [active]
395491006294	putative substrate binding site [chemical binding]; other site
395491006295	HRDC domain; Region: HRDC; pfam00570
395491006296	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
395491006297	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
395491006298	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
395491006299	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
395491006300	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
395491006301	dimer interface [polypeptide binding]; other site
395491006302	anticodon binding site; other site
395491006303	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
395491006304	homodimer interface [polypeptide binding]; other site
395491006305	motif 1; other site
395491006306	active site
395491006307	motif 2; other site
395491006308	GAD domain; Region: GAD; pfam02938
395491006309	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395491006310	active site
395491006311	motif 3; other site
395491006312	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395491006313	Beta-lactamase; Region: Beta-lactamase; pfam00144
395491006314	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491006315	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491006316	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
395491006317	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
395491006318	CAP-like domain; other site
395491006319	active site
395491006320	primary dimer interface [polypeptide binding]; other site
395491006321	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395491006322	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
395491006323	putative hydrophobic ligand binding site [chemical binding]; other site
395491006324	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
395491006325	putative addiction module antidote; Region: doc_partner; TIGR02609
395491006326	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
395491006327	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
395491006328	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
395491006329	Predicted membrane protein/domain [Function unknown]; Region: COG1714
395491006330	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
395491006331	dimer interface [polypeptide binding]; other site
395491006332	allosteric magnesium binding site [ion binding]; other site
395491006333	active site
395491006334	aspartate-rich active site metal binding site; other site
395491006335	Schiff base residues; other site
395491006336	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395491006337	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
395491006338	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
395491006339	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491006340	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491006341	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
395491006342	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
395491006343	dimer interface [polypeptide binding]; other site
395491006344	active site
395491006345	glycine-pyridoxal phosphate binding site [chemical binding]; other site
395491006346	folate binding site [chemical binding]; other site
395491006347	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
395491006348	ATP cone domain; Region: ATP-cone; pfam03477
395491006349	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
395491006350	catalytic motif [active]
395491006351	Zn binding site [ion binding]; other site
395491006352	RibD C-terminal domain; Region: RibD_C; cl17279
395491006353	RibD C-terminal domain; Region: RibD_C; cl17279
395491006354	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
395491006355	Lumazine binding domain; Region: Lum_binding; pfam00677
395491006356	Lumazine binding domain; Region: Lum_binding; pfam00677
395491006357	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
395491006358	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
395491006359	substrate binding site; other site
395491006360	tetramer interface; other site
395491006361	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
395491006362	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
395491006363	NADP binding site [chemical binding]; other site
395491006364	active site
395491006365	putative substrate binding site [chemical binding]; other site
395491006366	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
395491006367	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
395491006368	NAD binding site [chemical binding]; other site
395491006369	substrate binding site [chemical binding]; other site
395491006370	homodimer interface [polypeptide binding]; other site
395491006371	active site
395491006372	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
395491006373	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395491006374	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395491006375	Cupin domain; Region: Cupin_2; cl17218
395491006376	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
395491006377	homopentamer interface [polypeptide binding]; other site
395491006378	active site
395491006379	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
395491006380	putative RNA binding site [nucleotide binding]; other site
395491006381	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808
395491006382	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
395491006383	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
395491006384	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
395491006385	Uncharacterized conserved protein [Function unknown]; Region: COG5452
395491006386	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
395491006387	putative phosphate acyltransferase; Provisional; Region: PRK05331
395491006388	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
395491006389	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
395491006390	dimer interface [polypeptide binding]; other site
395491006391	active site
395491006392	CoA binding pocket [chemical binding]; other site
395491006393	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395491006394	IHF dimer interface [polypeptide binding]; other site
395491006395	IHF - DNA interface [nucleotide binding]; other site
395491006396	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
395491006397	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
395491006398	DNA binding residues [nucleotide binding]
395491006399	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491006400	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491006401	active site
395491006402	phosphorylation site [posttranslational modification]
395491006403	intermolecular recognition site; other site
395491006404	dimerization interface [polypeptide binding]; other site
395491006405	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
395491006406	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491006407	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491006408	dimer interface [polypeptide binding]; other site
395491006409	phosphorylation site [posttranslational modification]
395491006410	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491006411	ATP binding site [chemical binding]; other site
395491006412	Mg2+ binding site [ion binding]; other site
395491006413	G-X-G motif; other site
395491006414	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491006415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491006416	active site
395491006417	phosphorylation site [posttranslational modification]
395491006418	intermolecular recognition site; other site
395491006419	dimerization interface [polypeptide binding]; other site
395491006420	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
395491006421	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
395491006422	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
395491006423	DXD motif; other site
395491006424	PilZ domain; Region: PilZ; pfam07238
395491006425	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
395491006426	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
395491006427	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
395491006428	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491006429	motif II; other site
395491006430	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395491006431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491006432	S-adenosylmethionine binding site [chemical binding]; other site
395491006433	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491006434	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
395491006435	non-specific DNA binding site [nucleotide binding]; other site
395491006436	salt bridge; other site
395491006437	sequence-specific DNA binding site [nucleotide binding]; other site
395491006438	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395491006439	non-specific DNA interactions [nucleotide binding]; other site
395491006440	DNA binding site [nucleotide binding]
395491006441	sequence specific DNA binding site [nucleotide binding]; other site
395491006442	putative cAMP binding site [chemical binding]; other site
395491006443	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491006444	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
395491006445	nucleotide binding site [chemical binding]; other site
395491006446	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395491006447	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395491006448	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491006449	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491006450	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
395491006451	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491006452	dimer interface [polypeptide binding]; other site
395491006453	conserved gate region; other site
395491006454	putative PBP binding loops; other site
395491006455	ABC-ATPase subunit interface; other site
395491006456	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491006457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491006458	dimer interface [polypeptide binding]; other site
395491006459	conserved gate region; other site
395491006460	putative PBP binding loops; other site
395491006461	ABC-ATPase subunit interface; other site
395491006462	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
395491006463	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
395491006464	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491006465	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395491006466	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
395491006467	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
395491006468	SLBB domain; Region: SLBB; pfam10531
395491006469	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
395491006470	Chain length determinant protein; Region: Wzz; pfam02706
395491006471	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
395491006472	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
395491006473	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
395491006474	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
395491006475	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
395491006476	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
395491006477	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395491006478	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
395491006479	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
395491006480	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
395491006481	agmatinase; Region: agmatinase; TIGR01230
395491006482	oligomer interface [polypeptide binding]; other site
395491006483	putative active site [active]
395491006484	Mn binding site [ion binding]; other site
395491006485	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
395491006486	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491006487	putative substrate translocation pore; other site
395491006488	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
395491006489	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
395491006490	23S rRNA interface [nucleotide binding]; other site
395491006491	L3 interface [polypeptide binding]; other site
395491006492	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491006493	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491006494	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395491006495	dimerization interface [polypeptide binding]; other site
395491006496	enoyl-CoA hydratase; Validated; Region: PRK08139
395491006497	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395491006498	substrate binding site [chemical binding]; other site
395491006499	oxyanion hole (OAH) forming residues; other site
395491006500	trimer interface [polypeptide binding]; other site
395491006501	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
395491006502	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
395491006503	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
395491006504	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
395491006505	homodimer interface [polypeptide binding]; other site
395491006506	substrate-cofactor binding pocket; other site
395491006507	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491006508	catalytic residue [active]
395491006509	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
395491006510	CHASE4 domain; Region: CHASE4; pfam05228
395491006511	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491006512	metal binding site [ion binding]; metal-binding site
395491006513	active site
395491006514	I-site; other site
395491006515	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491006516	PBP superfamily domain; Region: PBP_like_2; cl17296
395491006517	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
395491006518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491006519	dimer interface [polypeptide binding]; other site
395491006520	conserved gate region; other site
395491006521	putative PBP binding loops; other site
395491006522	ABC-ATPase subunit interface; other site
395491006523	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
395491006524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491006525	dimer interface [polypeptide binding]; other site
395491006526	conserved gate region; other site
395491006527	putative PBP binding loops; other site
395491006528	ABC-ATPase subunit interface; other site
395491006529	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
395491006530	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
395491006531	Walker A/P-loop; other site
395491006532	ATP binding site [chemical binding]; other site
395491006533	Q-loop/lid; other site
395491006534	ABC transporter signature motif; other site
395491006535	Walker B; other site
395491006536	D-loop; other site
395491006537	H-loop/switch region; other site
395491006538	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
395491006539	Cytochrome P450; Region: p450; cl12078
395491006540	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491006541	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491006542	metal binding site [ion binding]; metal-binding site
395491006543	active site
395491006544	I-site; other site
395491006545	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
395491006546	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
395491006547	oligomer interface [polypeptide binding]; other site
395491006548	active site residues [active]
395491006549	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
395491006550	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
395491006551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491006552	Walker A motif; other site
395491006553	ATP binding site [chemical binding]; other site
395491006554	Walker B motif; other site
395491006555	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
395491006556	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
395491006557	Found in ATP-dependent protease La (LON); Region: LON; smart00464
395491006558	Found in ATP-dependent protease La (LON); Region: LON; smart00464
395491006559	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491006560	Walker A motif; other site
395491006561	ATP binding site [chemical binding]; other site
395491006562	Walker B motif; other site
395491006563	arginine finger; other site
395491006564	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
395491006565	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395491006566	IHF dimer interface [polypeptide binding]; other site
395491006567	IHF - DNA interface [nucleotide binding]; other site
395491006568	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395491006569	EamA-like transporter family; Region: EamA; pfam00892
395491006570	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
395491006571	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491006572	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491006573	active site
395491006574	catalytic tetrad [active]
395491006575	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
395491006576	Methyltransferase domain; Region: Methyltransf_24; pfam13578
395491006577	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
395491006578	catalytic residues [active]
395491006579	dimer interface [polypeptide binding]; other site
395491006580	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
395491006581	NADH dehydrogenase subunit B; Validated; Region: PRK06411
395491006582	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
395491006583	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
395491006584	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
395491006585	NADH dehydrogenase subunit D; Validated; Region: PRK06075
395491006586	NADH dehydrogenase subunit E; Provisional; Region: PRK12373
395491006587	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
395491006588	putative dimer interface [polypeptide binding]; other site
395491006589	[2Fe-2S] cluster binding site [ion binding]; other site
395491006590	Uncharacterized conserved protein [Function unknown]; Region: COG3743
395491006591	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
395491006592	SLBB domain; Region: SLBB; pfam10531
395491006593	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
395491006594	Uncharacterized conserved protein [Function unknown]; Region: COG3743
395491006595	NADH dehydrogenase subunit G; Validated; Region: PRK09130
395491006596	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395491006597	catalytic loop [active]
395491006598	iron binding site [ion binding]; other site
395491006599	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
395491006600	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
395491006601	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
395491006602	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
395491006603	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
395491006604	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
395491006605	4Fe-4S binding domain; Region: Fer4; pfam00037
395491006606	4Fe-4S binding domain; Region: Fer4; pfam00037
395491006607	NADH dehydrogenase subunit 6; Validated; Region: ND6; MTH00021
395491006608	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
395491006609	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
395491006610	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
395491006611	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
395491006612	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395491006613	NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
395491006614	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
395491006615	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395491006616	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
395491006617	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395491006618	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
395491006619	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
395491006620	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
395491006621	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
395491006622	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395491006623	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
395491006624	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491006625	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
395491006626	dimer interface [polypeptide binding]; other site
395491006627	substrate binding site [chemical binding]; other site
395491006628	metal binding site [ion binding]; metal-binding site
395491006629	Protein of unknown function (DUF1467); Region: DUF1467; cl11569
395491006630	prolyl-tRNA synthetase; Provisional; Region: PRK12325
395491006631	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
395491006632	dimer interface [polypeptide binding]; other site
395491006633	motif 1; other site
395491006634	active site
395491006635	motif 2; other site
395491006636	motif 3; other site
395491006637	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
395491006638	anticodon binding site; other site
395491006639	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
395491006640	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395491006641	FtsX-like permease family; Region: FtsX; pfam02687
395491006642	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395491006643	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395491006644	Walker A/P-loop; other site
395491006645	ATP binding site [chemical binding]; other site
395491006646	Q-loop/lid; other site
395491006647	ABC transporter signature motif; other site
395491006648	Walker B; other site
395491006649	D-loop; other site
395491006650	H-loop/switch region; other site
395491006651	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
395491006652	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
395491006653	putative active site [active]
395491006654	putative PHP Thumb interface [polypeptide binding]; other site
395491006655	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
395491006656	generic binding surface II; other site
395491006657	generic binding surface I; other site
395491006658	hypothetical protein; Provisional; Region: PRK06132
395491006659	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491006660	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491006661	DNA polymerase IV; Provisional; Region: PRK02794
395491006662	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
395491006663	active site
395491006664	DNA binding site [nucleotide binding]
395491006665	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491006666	Coenzyme A binding pocket [chemical binding]; other site
395491006667	hypothetical protein; Provisional; Region: 30.2; PHA02597
395491006668	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
395491006669	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491006670	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491006671	active site
395491006672	phosphorylation site [posttranslational modification]
395491006673	intermolecular recognition site; other site
395491006674	dimerization interface [polypeptide binding]; other site
395491006675	response regulator PleD; Reviewed; Region: pleD; PRK09581
395491006676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491006677	active site
395491006678	phosphorylation site [posttranslational modification]
395491006679	intermolecular recognition site; other site
395491006680	dimerization interface [polypeptide binding]; other site
395491006681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491006682	active site
395491006683	phosphorylation site [posttranslational modification]
395491006684	intermolecular recognition site; other site
395491006685	dimerization interface [polypeptide binding]; other site
395491006686	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491006687	metal binding site [ion binding]; metal-binding site
395491006688	active site
395491006689	I-site; other site
395491006690	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
395491006691	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491006692	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491006693	putative substrate translocation pore; other site
395491006694	hypothetical protein; Provisional; Region: PRK05978
395491006695	ribonuclease R; Region: RNase_R; TIGR02063
395491006696	RNB domain; Region: RNB; pfam00773
395491006697	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
395491006698	RNA binding site [nucleotide binding]; other site
395491006699	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
395491006700	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
395491006701	active site
395491006702	interdomain interaction site; other site
395491006703	putative metal-binding site [ion binding]; other site
395491006704	nucleotide binding site [chemical binding]; other site
395491006705	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
395491006706	domain I; other site
395491006707	DNA binding groove [nucleotide binding]
395491006708	phosphate binding site [ion binding]; other site
395491006709	domain II; other site
395491006710	domain III; other site
395491006711	nucleotide binding site [chemical binding]; other site
395491006712	catalytic site [active]
395491006713	domain IV; other site
395491006714	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
395491006715	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395491006716	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395491006717	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395491006718	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
395491006719	DNA protecting protein DprA; Region: dprA; TIGR00732
395491006720	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
395491006721	dihydroorotase; Validated; Region: PRK09059
395491006722	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491006723	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
395491006724	active site
395491006725	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
395491006726	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
395491006727	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
395491006728	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395491006729	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395491006730	active site
395491006731	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
395491006732	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
395491006733	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
395491006734	AMIN domain; Region: AMIN; pfam11741
395491006735	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
395491006736	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
395491006737	active site
395491006738	metal binding site [ion binding]; metal-binding site
395491006739	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
395491006740	Transglycosylase; Region: Transgly; pfam00912
395491006741	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395491006742	peptide chain release factor 2; Provisional; Region: PRK07342
395491006743	This domain is found in peptide chain release factors; Region: PCRF; smart00937
395491006744	RF-1 domain; Region: RF-1; pfam00472
395491006745	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491006746	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491006747	Walker A/P-loop; other site
395491006748	ATP binding site [chemical binding]; other site
395491006749	Q-loop/lid; other site
395491006750	ABC transporter signature motif; other site
395491006751	Walker B; other site
395491006752	D-loop; other site
395491006753	H-loop/switch region; other site
395491006754	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491006755	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491006756	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491006757	TM-ABC transporter signature motif; other site
395491006758	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
395491006759	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491006760	putative ligand binding site [chemical binding]; other site
395491006761	short chain dehydrogenase; Provisional; Region: PRK06841
395491006762	classical (c) SDRs; Region: SDR_c; cd05233
395491006763	NAD(P) binding site [chemical binding]; other site
395491006764	active site
395491006765	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
395491006766	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
395491006767	DAK2 domain; Region: Dak2; pfam02734
395491006768	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
395491006769	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491006770	DNA binding residues [nucleotide binding]
395491006771	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
395491006772	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
395491006773	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
395491006774	DAK2 domain; Region: Dak2; cl03685
395491006775	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395491006776	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
395491006777	ATP-NAD kinase; Region: NAD_kinase; pfam01513
395491006778	Protease inhibitor Inh; Region: Inh; pfam02974
395491006779	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
395491006780	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
395491006781	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
395491006782	elongation factor Tu; Reviewed; Region: PRK00049
395491006783	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
395491006784	G1 box; other site
395491006785	GEF interaction site [polypeptide binding]; other site
395491006786	GTP/Mg2+ binding site [chemical binding]; other site
395491006787	Switch I region; other site
395491006788	G2 box; other site
395491006789	G3 box; other site
395491006790	Switch II region; other site
395491006791	G4 box; other site
395491006792	G5 box; other site
395491006793	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
395491006794	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
395491006795	Antibiotic Binding Site [chemical binding]; other site
395491006796	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491006797	extended (e) SDRs; Region: SDR_e; cd08946
395491006798	NAD(P) binding site [chemical binding]; other site
395491006799	active site
395491006800	substrate binding site [chemical binding]; other site
395491006801	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
395491006802	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
395491006803	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
395491006804	putative homodimer interface [polypeptide binding]; other site
395491006805	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
395491006806	heterodimer interface [polypeptide binding]; other site
395491006807	homodimer interface [polypeptide binding]; other site
395491006808	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
395491006809	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
395491006810	23S rRNA interface [nucleotide binding]; other site
395491006811	L7/L12 interface [polypeptide binding]; other site
395491006812	putative thiostrepton binding site; other site
395491006813	L25 interface [polypeptide binding]; other site
395491006814	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
395491006815	mRNA/rRNA interface [nucleotide binding]; other site
395491006816	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
395491006817	23S rRNA interface [nucleotide binding]; other site
395491006818	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
395491006819	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
395491006820	L11 interface [polypeptide binding]; other site
395491006821	putative EF-Tu interaction site [polypeptide binding]; other site
395491006822	putative EF-G interaction site [polypeptide binding]; other site
395491006823	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
395491006824	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
395491006825	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
395491006826	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
395491006827	RPB11 interaction site [polypeptide binding]; other site
395491006828	RPB12 interaction site [polypeptide binding]; other site
395491006829	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
395491006830	RPB1 interaction site [polypeptide binding]; other site
395491006831	RPB11 interaction site [polypeptide binding]; other site
395491006832	RPB10 interaction site [polypeptide binding]; other site
395491006833	RPB3 interaction site [polypeptide binding]; other site
395491006834	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
395491006835	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
395491006836	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
395491006837	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
395491006838	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
395491006839	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
395491006840	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
395491006841	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
395491006842	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
395491006843	DNA binding site [nucleotide binding]
395491006844	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
395491006845	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
395491006846	S17 interaction site [polypeptide binding]; other site
395491006847	S8 interaction site; other site
395491006848	16S rRNA interaction site [nucleotide binding]; other site
395491006849	streptomycin interaction site [chemical binding]; other site
395491006850	23S rRNA interaction site [nucleotide binding]; other site
395491006851	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
395491006852	30S ribosomal protein S7; Validated; Region: PRK05302
395491006853	elongation factor G; Reviewed; Region: PRK00007
395491006854	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
395491006855	G1 box; other site
395491006856	putative GEF interaction site [polypeptide binding]; other site
395491006857	GTP/Mg2+ binding site [chemical binding]; other site
395491006858	Switch I region; other site
395491006859	G2 box; other site
395491006860	G3 box; other site
395491006861	Switch II region; other site
395491006862	G4 box; other site
395491006863	G5 box; other site
395491006864	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
395491006865	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
395491006866	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
395491006867	elongation factor Tu; Reviewed; Region: PRK00049
395491006868	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
395491006869	G1 box; other site
395491006870	GEF interaction site [polypeptide binding]; other site
395491006871	GTP/Mg2+ binding site [chemical binding]; other site
395491006872	Switch I region; other site
395491006873	G2 box; other site
395491006874	G3 box; other site
395491006875	Switch II region; other site
395491006876	G4 box; other site
395491006877	G5 box; other site
395491006878	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
395491006879	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
395491006880	Antibiotic Binding Site [chemical binding]; other site
395491006881	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
395491006882	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
395491006883	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
395491006884	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
395491006885	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
395491006886	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
395491006887	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
395491006888	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
395491006889	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
395491006890	putative translocon binding site; other site
395491006891	protein-rRNA interface [nucleotide binding]; other site
395491006892	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
395491006893	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
395491006894	G-X-X-G motif; other site
395491006895	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
395491006896	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
395491006897	23S rRNA interface [nucleotide binding]; other site
395491006898	5S rRNA interface [nucleotide binding]; other site
395491006899	putative antibiotic binding site [chemical binding]; other site
395491006900	L25 interface [polypeptide binding]; other site
395491006901	L27 interface [polypeptide binding]; other site
395491006902	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
395491006903	23S rRNA interface [nucleotide binding]; other site
395491006904	putative translocon interaction site; other site
395491006905	signal recognition particle (SRP54) interaction site; other site
395491006906	L23 interface [polypeptide binding]; other site
395491006907	trigger factor interaction site; other site
395491006908	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
395491006909	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
395491006910	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
395491006911	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
395491006912	RNA binding site [nucleotide binding]; other site
395491006913	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
395491006914	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
395491006915	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
395491006916	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
395491006917	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
395491006918	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
395491006919	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
395491006920	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
395491006921	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
395491006922	23S rRNA interface [nucleotide binding]; other site
395491006923	L21e interface [polypeptide binding]; other site
395491006924	5S rRNA interface [nucleotide binding]; other site
395491006925	L27 interface [polypeptide binding]; other site
395491006926	L5 interface [polypeptide binding]; other site
395491006927	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
395491006928	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
395491006929	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
395491006930	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
395491006931	23S rRNA binding site [nucleotide binding]; other site
395491006932	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
395491006933	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
395491006934	SecY translocase; Region: SecY; pfam00344
395491006935	adenylate kinase; Reviewed; Region: adk; PRK00279
395491006936	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
395491006937	AMP-binding site [chemical binding]; other site
395491006938	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
395491006939	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
395491006940	30S ribosomal protein S13; Region: bact_S13; TIGR03631
395491006941	30S ribosomal protein S11; Validated; Region: PRK05309
395491006942	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
395491006943	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
395491006944	alphaNTD homodimer interface [polypeptide binding]; other site
395491006945	alphaNTD - beta interaction site [polypeptide binding]; other site
395491006946	alphaNTD - beta' interaction site [polypeptide binding]; other site
395491006947	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
395491006948	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
395491006949	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
395491006950	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
395491006951	TMAO/DMSO reductase; Reviewed; Region: PRK05363
395491006952	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
395491006953	Moco binding site; other site
395491006954	metal coordination site [ion binding]; other site
395491006955	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
395491006956	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
395491006957	Uncharacterized conserved protein [Function unknown]; Region: COG3339
395491006958	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
395491006959	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395491006960	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395491006961	protein binding site [polypeptide binding]; other site
395491006962	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395491006963	protein binding site [polypeptide binding]; other site
395491006964	recombination factor protein RarA; Reviewed; Region: PRK13342
395491006965	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491006966	Walker A motif; other site
395491006967	ATP binding site [chemical binding]; other site
395491006968	Walker B motif; other site
395491006969	arginine finger; other site
395491006970	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
395491006971	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
395491006972	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491006973	Class I aldolases; Region: Aldolase_Class_I; cl17187
395491006974	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
395491006975	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
395491006976	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
395491006977	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
395491006978	short chain dehydrogenase; Provisional; Region: PRK06180
395491006979	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395491006980	NADP binding site [chemical binding]; other site
395491006981	active site
395491006982	steroid binding site; other site
395491006983	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491006984	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491006985	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395491006986	putative effector binding pocket; other site
395491006987	putative dimerization interface [polypeptide binding]; other site
395491006988	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
395491006989	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
395491006990	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
395491006991	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395491006992	PAS domain; Region: PAS; smart00091
395491006993	PAS fold; Region: PAS_7; pfam12860
395491006994	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395491006995	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491006996	dimer interface [polypeptide binding]; other site
395491006997	phosphorylation site [posttranslational modification]
395491006998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491006999	ATP binding site [chemical binding]; other site
395491007000	Mg2+ binding site [ion binding]; other site
395491007001	G-X-G motif; other site
395491007002	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491007003	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491007004	DNA binding site [nucleotide binding]
395491007005	domain linker motif; other site
395491007006	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
395491007007	putative dimerization interface [polypeptide binding]; other site
395491007008	putative ligand binding site [chemical binding]; other site
395491007009	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
395491007010	Coenzyme A transferase; Region: CoA_trans; smart00882
395491007011	Coenzyme A transferase; Region: CoA_trans; cl17247
395491007012	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
395491007013	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395491007014	substrate binding site [chemical binding]; other site
395491007015	oxyanion hole (OAH) forming residues; other site
395491007016	trimer interface [polypeptide binding]; other site
395491007017	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395491007018	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
395491007019	NAD(P) binding site [chemical binding]; other site
395491007020	catalytic residues [active]
395491007021	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491007022	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491007023	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491007024	dimer interface [polypeptide binding]; other site
395491007025	putative PBP binding loops; other site
395491007026	ABC-ATPase subunit interface; other site
395491007027	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491007028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491007029	dimer interface [polypeptide binding]; other site
395491007030	conserved gate region; other site
395491007031	putative PBP binding loops; other site
395491007032	ABC-ATPase subunit interface; other site
395491007033	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491007034	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491007035	Walker A/P-loop; other site
395491007036	ATP binding site [chemical binding]; other site
395491007037	Q-loop/lid; other site
395491007038	ABC transporter signature motif; other site
395491007039	Walker B; other site
395491007040	D-loop; other site
395491007041	H-loop/switch region; other site
395491007042	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
395491007043	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395491007044	choline dehydrogenase; Validated; Region: PRK02106
395491007045	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395491007046	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491007047	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491007048	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491007049	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
395491007050	L-aspartate oxidase; Provisional; Region: PRK06175
395491007051	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
395491007052	putative catalytic site [active]
395491007053	putative phosphate binding site [ion binding]; other site
395491007054	active site
395491007055	metal binding site A [ion binding]; metal-binding site
395491007056	DNA binding site [nucleotide binding]
395491007057	putative AP binding site [nucleotide binding]; other site
395491007058	putative metal binding site B [ion binding]; other site
395491007059	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491007060	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491007061	active site
395491007062	phosphorylation site [posttranslational modification]
395491007063	intermolecular recognition site; other site
395491007064	dimerization interface [polypeptide binding]; other site
395491007065	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491007066	DNA binding residues [nucleotide binding]
395491007067	dimerization interface [polypeptide binding]; other site
395491007068	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
395491007069	Histidine kinase; Region: HisKA_3; pfam07730
395491007070	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491007071	ATP binding site [chemical binding]; other site
395491007072	Mg2+ binding site [ion binding]; other site
395491007073	G-X-G motif; other site
395491007074	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
395491007075	BA14K-like protein; Region: BA14K; pfam07886
395491007076	BA14K-like protein; Region: BA14K; pfam07886
395491007077	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491007078	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491007079	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395491007080	putative effector binding pocket; other site
395491007081	putative dimerization interface [polypeptide binding]; other site
395491007082	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
395491007083	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491007084	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395491007085	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491007086	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
395491007087	cofactor binding site; other site
395491007088	metal binding site [ion binding]; metal-binding site
395491007089	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491007090	putative DNA binding site [nucleotide binding]; other site
395491007091	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491007092	putative Zn2+ binding site [ion binding]; other site
395491007093	AsnC family; Region: AsnC_trans_reg; pfam01037
395491007094	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491007095	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
395491007096	AsnC family; Region: AsnC_trans_reg; pfam01037
395491007097	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
395491007098	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
395491007099	dimer interface [polypeptide binding]; other site
395491007100	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
395491007101	active site
395491007102	Fe binding site [ion binding]; other site
395491007103	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
395491007104	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
395491007105	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
395491007106	maleylacetoacetate isomerase; Region: maiA; TIGR01262
395491007107	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
395491007108	C-terminal domain interface [polypeptide binding]; other site
395491007109	GSH binding site (G-site) [chemical binding]; other site
395491007110	putative dimer interface [polypeptide binding]; other site
395491007111	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
395491007112	dimer interface [polypeptide binding]; other site
395491007113	N-terminal domain interface [polypeptide binding]; other site
395491007114	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
395491007115	Predicted periplasmic protein [Function unknown]; Region: COG3904
395491007116	TniQ; Region: TniQ; pfam06527
395491007117	AAA domain; Region: AAA_22; pfam13401
395491007118	Integrase core domain; Region: rve; pfam00665
395491007119	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
395491007120	putative active site [active]
395491007121	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
395491007122	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
395491007123	active site
395491007124	FMN binding site [chemical binding]; other site
395491007125	substrate binding site [chemical binding]; other site
395491007126	homotetramer interface [polypeptide binding]; other site
395491007127	catalytic residue [active]
395491007128	Predicted transcriptional regulators [Transcription]; Region: COG1733
395491007129	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395491007130	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
395491007131	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
395491007132	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395491007133	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
395491007134	putative dimer interface [polypeptide binding]; other site
395491007135	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395491007136	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395491007137	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491007138	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491007139	ligand binding site [chemical binding]; other site
395491007140	flexible hinge region; other site
395491007141	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
395491007142	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
395491007143	dimerization interface [polypeptide binding]; other site
395491007144	DPS ferroxidase diiron center [ion binding]; other site
395491007145	ion pore; other site
395491007146	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
395491007147	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
395491007148	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
395491007149	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
395491007150	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
395491007151	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
395491007152	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
395491007153	GAF domain; Region: GAF; cl17456
395491007154	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491007155	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491007156	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491007157	putative active site [active]
395491007158	heme pocket [chemical binding]; other site
395491007159	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491007160	putative active site [active]
395491007161	heme pocket [chemical binding]; other site
395491007162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491007163	PAS fold; Region: PAS_3; pfam08447
395491007164	putative active site [active]
395491007165	heme pocket [chemical binding]; other site
395491007166	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491007167	dimer interface [polypeptide binding]; other site
395491007168	phosphorylation site [posttranslational modification]
395491007169	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491007170	ATP binding site [chemical binding]; other site
395491007171	G-X-G motif; other site
395491007172	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
395491007173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491007174	active site
395491007175	phosphorylation site [posttranslational modification]
395491007176	intermolecular recognition site; other site
395491007177	dimerization interface [polypeptide binding]; other site
395491007178	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491007179	DNA binding residues [nucleotide binding]
395491007180	dimerization interface [polypeptide binding]; other site
395491007181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491007182	active site
395491007183	phosphorylation site [posttranslational modification]
395491007184	intermolecular recognition site; other site
395491007185	dimerization interface [polypeptide binding]; other site
395491007186	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
395491007187	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
395491007188	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395491007189	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491007190	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491007191	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491007192	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
395491007193	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491007194	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491007195	DNA binding site [nucleotide binding]
395491007196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491007197	Response regulator receiver domain; Region: Response_reg; pfam00072
395491007198	active site
395491007199	phosphorylation site [posttranslational modification]
395491007200	intermolecular recognition site; other site
395491007201	dimerization interface [polypeptide binding]; other site
395491007202	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491007203	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395491007204	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395491007205	Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576
395491007206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
395491007207	SnoaL-like domain; Region: SnoaL_2; pfam12680
395491007208	Caspase domain; Region: Peptidase_C14; pfam00656
395491007209	active site
395491007210	substrate pocket [chemical binding]; other site
395491007211	proteolytic cleavage site; other site
395491007212	dimer interface [polypeptide binding]; other site
395491007213	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491007214	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491007215	putative active site [active]
395491007216	heme pocket [chemical binding]; other site
395491007217	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491007218	putative active site [active]
395491007219	heme pocket [chemical binding]; other site
395491007220	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395491007221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491007222	putative active site [active]
395491007223	heme pocket [chemical binding]; other site
395491007224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491007225	dimer interface [polypeptide binding]; other site
395491007226	phosphorylation site [posttranslational modification]
395491007227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491007228	ATP binding site [chemical binding]; other site
395491007229	Mg2+ binding site [ion binding]; other site
395491007230	G-X-G motif; other site
395491007231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
395491007232	Domain of unknown function DUF302; Region: DUF302; cl01364
395491007233	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491007234	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395491007235	NAD(P) binding site [chemical binding]; other site
395491007236	active site
395491007237	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491007238	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395491007239	short chain dehydrogenase; Provisional; Region: PRK06500
395491007240	classical (c) SDRs; Region: SDR_c; cd05233
395491007241	NAD(P) binding site [chemical binding]; other site
395491007242	active site
395491007243	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
395491007244	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
395491007245	substrate binding site [chemical binding]; other site
395491007246	activation loop (A-loop); other site
395491007247	Predicted ATPase [General function prediction only]; Region: COG3899
395491007248	AAA ATPase domain; Region: AAA_16; pfam13191
395491007249	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395491007250	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395491007251	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491007252	putative active site [active]
395491007253	PAS fold; Region: PAS_3; pfam08447
395491007254	heme pocket [chemical binding]; other site
395491007255	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491007256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491007257	ATP binding site [chemical binding]; other site
395491007258	G-X-G motif; other site
395491007259	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395491007260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491007261	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
395491007262	Walker A motif; other site
395491007263	ATP binding site [chemical binding]; other site
395491007264	Walker B motif; other site
395491007265	arginine finger; other site
395491007266	Peptidase family M41; Region: Peptidase_M41; pfam01434
395491007267	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
395491007268	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
395491007269	cofactor binding site; other site
395491007270	DNA binding site [nucleotide binding]
395491007271	substrate interaction site [chemical binding]; other site
395491007272	This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901
395491007273	Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172
395491007274	PLD-like domain; Region: PLDc_2; pfam13091
395491007275	putative active site [active]
395491007276	catalytic site [active]
395491007277	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
395491007278	PLD-like domain; Region: PLDc_2; pfam13091
395491007279	putative active site [active]
395491007280	catalytic site [active]
395491007281	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
395491007282	Part of AAA domain; Region: AAA_19; pfam13245
395491007283	Family description; Region: UvrD_C_2; pfam13538
395491007284	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
395491007285	AIPR protein; Region: AIPR; pfam10592
395491007286	hypothetical protein; Provisional; Region: PRK10508
395491007287	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491007288	AAA domain; Region: AAA_23; pfam13476
395491007289	Walker A/P-loop; other site
395491007290	ATP binding site [chemical binding]; other site
395491007291	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491007292	Walker B; other site
395491007293	D-loop; other site
395491007294	H-loop/switch region; other site
395491007295	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395491007296	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395491007297	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
395491007298	active site
395491007299	metal binding site [ion binding]; metal-binding site
395491007300	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395491007301	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
395491007302	active site
395491007303	iron coordination sites [ion binding]; other site
395491007304	substrate binding pocket [chemical binding]; other site
395491007305	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
395491007306	active site
395491007307	NTP binding site [chemical binding]; other site
395491007308	metal binding triad [ion binding]; metal-binding site
395491007309	HNH endonuclease; Region: HNH_2; pfam13391
395491007310	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
395491007311	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
395491007312	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
395491007313	Transcriptional regulator; Region: Transcrip_reg; cl00361
395491007314	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
395491007315	active site
395491007316	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
395491007317	TSCPD domain; Region: TSCPD; pfam12637
395491007318	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395491007319	active site
395491007320	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395491007321	Ligand Binding Site [chemical binding]; other site
395491007322	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
395491007323	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
395491007324	putative MPT binding site; other site
395491007325	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
395491007326	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491007327	threonine dehydratase; Validated; Region: PRK08639
395491007328	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
395491007329	tetramer interface [polypeptide binding]; other site
395491007330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491007331	catalytic residue [active]
395491007332	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
395491007333	Transcriptional activator HlyU; Region: HlyU; pfam10115
395491007334	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491007335	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491007336	metal binding site [ion binding]; metal-binding site
395491007337	active site
395491007338	I-site; other site
395491007339	short chain dehydrogenase; Provisional; Region: PRK06500
395491007340	classical (c) SDRs; Region: SDR_c; cd05233
395491007341	NAD(P) binding site [chemical binding]; other site
395491007342	active site
395491007343	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491007344	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491007345	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
395491007346	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491007347	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491007348	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491007349	LysR substrate binding domain; Region: LysR_substrate; pfam03466
395491007350	dimerization interface [polypeptide binding]; other site
395491007351	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
395491007352	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
395491007353	active site
395491007354	metal binding site [ion binding]; metal-binding site
395491007355	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
395491007356	PilZ domain; Region: PilZ; pfam07238
395491007357	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395491007358	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491007359	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491007360	putative DNA binding site [nucleotide binding]; other site
395491007361	putative Zn2+ binding site [ion binding]; other site
395491007362	AsnC family; Region: AsnC_trans_reg; pfam01037
395491007363	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
395491007364	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
395491007365	hexamer interface [polypeptide binding]; other site
395491007366	ligand binding site [chemical binding]; other site
395491007367	putative active site [active]
395491007368	NAD(P) binding site [chemical binding]; other site
395491007369	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
395491007370	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491007371	S-adenosylmethionine binding site [chemical binding]; other site
395491007372	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395491007373	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
395491007374	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
395491007375	active site residue [active]
395491007376	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
395491007377	active site residue [active]
395491007378	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
395491007379	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
395491007380	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
395491007381	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
395491007382	dimer interface [polypeptide binding]; other site
395491007383	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491007384	catalytic residue [active]
395491007385	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
395491007386	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
395491007387	short chain dehydrogenase; Provisional; Region: PRK06101
395491007388	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491007389	NAD(P) binding site [chemical binding]; other site
395491007390	active site
395491007391	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
395491007392	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395491007393	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491007394	S-adenosylmethionine binding site [chemical binding]; other site
395491007395	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
395491007396	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
395491007397	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395491007398	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
395491007399	DNA photolyase; Region: DNA_photolyase; pfam00875
395491007400	putative phosphatase; Provisional; Region: PRK11587
395491007401	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
395491007402	motif II; other site
395491007403	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
395491007404	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
395491007405	[4Fe-4S] binding site [ion binding]; other site
395491007406	molybdopterin cofactor binding site; other site
395491007407	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
395491007408	molybdopterin cofactor binding site; other site
395491007409	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
395491007410	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
395491007411	[2Fe-2S] cluster binding site [ion binding]; other site
395491007412	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
395491007413	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395491007414	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
395491007415	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
395491007416	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395491007417	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
395491007418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491007419	putative substrate translocation pore; other site
395491007420	NMT1-like family; Region: NMT1_2; pfam13379
395491007421	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395491007422	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
395491007423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491007424	active site
395491007425	phosphorylation site [posttranslational modification]
395491007426	intermolecular recognition site; other site
395491007427	ANTAR domain; Region: ANTAR; pfam03861
395491007428	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
395491007429	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
395491007430	C-terminal domain interface [polypeptide binding]; other site
395491007431	GSH binding site (G-site) [chemical binding]; other site
395491007432	dimer interface [polypeptide binding]; other site
395491007433	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395491007434	N-terminal domain interface [polypeptide binding]; other site
395491007435	dimer interface [polypeptide binding]; other site
395491007436	substrate binding pocket (H-site) [chemical binding]; other site
395491007437	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491007438	dimerization interface [polypeptide binding]; other site
395491007439	putative DNA binding site [nucleotide binding]; other site
395491007440	putative Zn2+ binding site [ion binding]; other site
395491007441	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
395491007442	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491007443	membrane-bound complex binding site; other site
395491007444	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
395491007445	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
395491007446	dimer interface [polypeptide binding]; other site
395491007447	non-prolyl cis peptide bond; other site
395491007448	active site
395491007449	insertion regions; other site
395491007450	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
395491007451	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
395491007452	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
395491007453	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
395491007454	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
395491007455	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
395491007456	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
395491007457	dimer interface [polypeptide binding]; other site
395491007458	decamer (pentamer of dimers) interface [polypeptide binding]; other site
395491007459	catalytic triad [active]
395491007460	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
395491007461	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
395491007462	C-terminal domain interface [polypeptide binding]; other site
395491007463	GSH binding site (G-site) [chemical binding]; other site
395491007464	dimer interface [polypeptide binding]; other site
395491007465	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
395491007466	dimer interface [polypeptide binding]; other site
395491007467	N-terminal domain interface [polypeptide binding]; other site
395491007468	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395491007469	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395491007470	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395491007471	catalytic residue [active]
395491007472	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491007473	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491007474	NAD(P) binding site [chemical binding]; other site
395491007475	active site
395491007476	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491007477	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
395491007478	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
395491007479	MOFRL family; Region: MOFRL; pfam05161
395491007480	hypothetical protein; Validated; Region: PRK09104
395491007481	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
395491007482	metal binding site [ion binding]; metal-binding site
395491007483	putative dimer interface [polypeptide binding]; other site
395491007484	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395491007485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491007486	Walker A/P-loop; other site
395491007487	ATP binding site [chemical binding]; other site
395491007488	Q-loop/lid; other site
395491007489	ABC transporter signature motif; other site
395491007490	Walker B; other site
395491007491	D-loop; other site
395491007492	H-loop/switch region; other site
395491007493	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491007494	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491007495	dimer interface [polypeptide binding]; other site
395491007496	conserved gate region; other site
395491007497	putative PBP binding loops; other site
395491007498	ABC-ATPase subunit interface; other site
395491007499	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
395491007500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491007501	dimer interface [polypeptide binding]; other site
395491007502	conserved gate region; other site
395491007503	putative PBP binding loops; other site
395491007504	ABC-ATPase subunit interface; other site
395491007505	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
395491007506	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
395491007507	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
395491007508	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491007509	active site
395491007510	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
395491007511	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
395491007512	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491007513	Walker A/P-loop; other site
395491007514	ATP binding site [chemical binding]; other site
395491007515	Q-loop/lid; other site
395491007516	ABC transporter signature motif; other site
395491007517	Walker B; other site
395491007518	D-loop; other site
395491007519	H-loop/switch region; other site
395491007520	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
395491007521	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491007522	ABC-ATPase subunit  interface; other site
395491007523	dimer interface [polypeptide binding]; other site
395491007524	putative PBP binding regions; other site
395491007525	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
395491007526	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
395491007527	intersubunit interface [polypeptide binding]; other site
395491007528	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
395491007529	Cupin; Region: Cupin_6; pfam12852
395491007530	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491007531	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491007532	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
395491007533	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395491007534	putative NAD(P) binding site [chemical binding]; other site
395491007535	short chain dehydrogenase; Provisional; Region: PRK06500
395491007536	classical (c) SDRs; Region: SDR_c; cd05233
395491007537	NAD(P) binding site [chemical binding]; other site
395491007538	active site
395491007539	hydroperoxidase II; Provisional; Region: katE; PRK11249
395491007540	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
395491007541	tetramer interface [polypeptide binding]; other site
395491007542	heme binding pocket [chemical binding]; other site
395491007543	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
395491007544	domain interactions; other site
395491007545	KTSC domain; Region: KTSC; pfam13619
395491007546	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
395491007547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491007548	S-adenosylmethionine binding site [chemical binding]; other site
395491007549	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
395491007550	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
395491007551	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
395491007552	HIGH motif; other site
395491007553	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
395491007554	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
395491007555	active site
395491007556	KMSKS motif; other site
395491007557	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
395491007558	tRNA binding surface [nucleotide binding]; other site
395491007559	anticodon binding site; other site
395491007560	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
395491007561	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
395491007562	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395491007563	Sel1-like repeats; Region: SEL1; smart00671
395491007564	Sel1-like repeats; Region: SEL1; smart00671
395491007565	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
395491007566	putative catalytic site [active]
395491007567	putative phosphate binding site [ion binding]; other site
395491007568	active site
395491007569	metal binding site A [ion binding]; metal-binding site
395491007570	DNA binding site [nucleotide binding]
395491007571	putative AP binding site [nucleotide binding]; other site
395491007572	putative metal binding site B [ion binding]; other site
395491007573	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
395491007574	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
395491007575	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395491007576	Zn2+ binding site [ion binding]; other site
395491007577	Mg2+ binding site [ion binding]; other site
395491007578	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
395491007579	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
395491007580	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
395491007581	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
395491007582	active site
395491007583	HIGH motif; other site
395491007584	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395491007585	KMSK motif region; other site
395491007586	tRNA binding surface [nucleotide binding]; other site
395491007587	DALR anticodon binding domain; Region: DALR_1; smart00836
395491007588	anticodon binding site; other site
395491007589	Sporulation related domain; Region: SPOR; pfam05036
395491007590	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
395491007591	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
395491007592	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
395491007593	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
395491007594	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
395491007595	sec-independent translocase; Provisional; Region: PRK00708
395491007596	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
395491007597	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
395491007598	seryl-tRNA synthetase; Provisional; Region: PRK05431
395491007599	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
395491007600	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
395491007601	dimer interface [polypeptide binding]; other site
395491007602	active site
395491007603	motif 1; other site
395491007604	motif 2; other site
395491007605	motif 3; other site
395491007606	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
395491007607	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
395491007608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395491007609	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491007610	S-adenosylmethionine binding site [chemical binding]; other site
395491007611	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
395491007612	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
395491007613	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
395491007614	Peptidase family M23; Region: Peptidase_M23; pfam01551
395491007615	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
395491007616	Protein of unknown function (DUF815); Region: DUF815; pfam05673
395491007617	Walker A motif; other site
395491007618	ATP binding site [chemical binding]; other site
395491007619	Walker B motif; other site
395491007620	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
395491007621	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
395491007622	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
395491007623	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
395491007624	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
395491007625	Protein export membrane protein; Region: SecD_SecF; pfam02355
395491007626	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
395491007627	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
395491007628	substrate binding pocket [chemical binding]; other site
395491007629	substrate-Mg2+ binding site; other site
395491007630	aspartate-rich region 1; other site
395491007631	aspartate-rich region 2; other site
395491007632	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
395491007633	Glucose inhibited division protein A; Region: GIDA; pfam01134
395491007634	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
395491007635	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
395491007636	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
395491007637	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
395491007638	trigger factor; Provisional; Region: tig; PRK01490
395491007639	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
395491007640	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
395491007641	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
395491007642	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
395491007643	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395491007644	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
395491007645	FeS/SAM binding site; other site
395491007646	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
395491007647	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395491007648	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395491007649	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395491007650	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
395491007651	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395491007652	phosphate binding site [ion binding]; other site
395491007653	hypothetical protein; Reviewed; Region: PRK00024
395491007654	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
395491007655	MPN+ (JAMM) motif; other site
395491007656	Zinc-binding site [ion binding]; other site
395491007657	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
395491007658	active site
395491007659	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491007660	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491007661	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
395491007662	metal-dependent hydrolase; Provisional; Region: PRK00685
395491007663	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
395491007664	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
395491007665	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
395491007666	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
395491007667	hypothetical protein; Provisional; Region: PRK13687
395491007668	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395491007669	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491007670	Coenzyme A binding pocket [chemical binding]; other site
395491007671	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
395491007672	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
395491007673	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
395491007674	GatB domain; Region: GatB_Yqey; smart00845
395491007675	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
395491007676	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491007677	Coenzyme A binding pocket [chemical binding]; other site
395491007678	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
395491007679	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
395491007680	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491007681	Coenzyme A binding pocket [chemical binding]; other site
395491007682	NADH dehydrogenase; Validated; Region: PRK08183
395491007683	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
395491007684	Protein of unknown function (DUF2167); Region: DUF2167; cl01938
395491007685	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
395491007686	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
395491007687	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395491007688	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395491007689	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
395491007690	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
395491007691	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395491007692	carboxyltransferase (CT) interaction site; other site
395491007693	biotinylation site [posttranslational modification]; other site
395491007694	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
395491007695	Dehydroquinase class II; Region: DHquinase_II; pfam01220
395491007696	trimer interface [polypeptide binding]; other site
395491007697	active site
395491007698	dimer interface [polypeptide binding]; other site
395491007699	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
395491007700	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
395491007701	catalytic residues [active]
395491007702	aspartate aminotransferase; Provisional; Region: PRK05764
395491007703	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491007704	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491007705	homodimer interface [polypeptide binding]; other site
395491007706	catalytic residue [active]
395491007707	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
395491007708	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
395491007709	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
395491007710	aminotransferase; Validated; Region: PRK09148
395491007711	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491007712	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491007713	homodimer interface [polypeptide binding]; other site
395491007714	catalytic residue [active]
395491007715	homoserine dehydrogenase; Provisional; Region: PRK06349
395491007716	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
395491007717	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
395491007718	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
395491007719	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
395491007720	DHH family; Region: DHH; pfam01368
395491007721	DHHA1 domain; Region: DHHA1; pfam02272
395491007722	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
395491007723	Peptidase M15; Region: Peptidase_M15_3; cl01194
395491007724	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491007725	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
395491007726	dimer interface [polypeptide binding]; other site
395491007727	active site
395491007728	metal binding site [ion binding]; metal-binding site
395491007729	glutathione binding site [chemical binding]; other site
395491007730	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395491007731	DNA-binding site [nucleotide binding]; DNA binding site
395491007732	RNA-binding motif; other site
395491007733	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395491007734	DNA-binding site [nucleotide binding]; DNA binding site
395491007735	RNA-binding motif; other site
395491007736	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
395491007737	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
395491007738	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
395491007739	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
395491007740	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
395491007741	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491007742	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
395491007743	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395491007744	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491007745	Walker A/P-loop; other site
395491007746	ATP binding site [chemical binding]; other site
395491007747	Q-loop/lid; other site
395491007748	ABC transporter signature motif; other site
395491007749	Walker B; other site
395491007750	D-loop; other site
395491007751	H-loop/switch region; other site
395491007752	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491007753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491007754	dimer interface [polypeptide binding]; other site
395491007755	conserved gate region; other site
395491007756	putative PBP binding loops; other site
395491007757	ABC-ATPase subunit interface; other site
395491007758	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
395491007759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491007760	conserved gate region; other site
395491007761	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491007762	dimer interface [polypeptide binding]; other site
395491007763	conserved gate region; other site
395491007764	putative PBP binding loops; other site
395491007765	ABC-ATPase subunit interface; other site
395491007766	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
395491007767	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491007768	substrate binding pocket [chemical binding]; other site
395491007769	membrane-bound complex binding site; other site
395491007770	hinge residues; other site
395491007771	cystathionine beta-lyase; Provisional; Region: PRK05967
395491007772	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
395491007773	homodimer interface [polypeptide binding]; other site
395491007774	substrate-cofactor binding pocket; other site
395491007775	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491007776	catalytic residue [active]
395491007777	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491007778	salicylate hydroxylase; Provisional; Region: PRK08163
395491007779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
395491007780	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491007781	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395491007782	serine acetyltransferase; Provisional; Region: cysE; PRK11132
395491007783	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
395491007784	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
395491007785	trimer interface [polypeptide binding]; other site
395491007786	active site
395491007787	substrate binding site [chemical binding]; other site
395491007788	CoA binding site [chemical binding]; other site
395491007789	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
395491007790	Phasin protein; Region: Phasin_2; pfam09361
395491007791	Uncharacterized conserved protein [Function unknown]; Region: COG2127
395491007792	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
395491007793	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491007794	Walker A motif; other site
395491007795	ATP binding site [chemical binding]; other site
395491007796	Walker B motif; other site
395491007797	arginine finger; other site
395491007798	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491007799	Walker A motif; other site
395491007800	ATP binding site [chemical binding]; other site
395491007801	Walker B motif; other site
395491007802	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
395491007803	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
395491007804	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
395491007805	HIT family signature motif; other site
395491007806	catalytic residue [active]
395491007807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
395491007808	Protein of unknown function, DUF482; Region: DUF482; pfam04339
395491007809	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
395491007810	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
395491007811	putative active site [active]
395491007812	catalytic site [active]
395491007813	putative metal binding site [ion binding]; other site
395491007814	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
395491007815	homotrimer interaction site [polypeptide binding]; other site
395491007816	putative active site [active]
395491007817	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
395491007818	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
395491007819	rRNA interaction site [nucleotide binding]; other site
395491007820	S8 interaction site; other site
395491007821	putative laminin-1 binding site; other site
395491007822	elongation factor Ts; Provisional; Region: tsf; PRK09377
395491007823	UBA/TS-N domain; Region: UBA; pfam00627
395491007824	Elongation factor TS; Region: EF_TS; pfam00889
395491007825	Elongation factor TS; Region: EF_TS; pfam00889
395491007826	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
395491007827	putative nucleotide binding site [chemical binding]; other site
395491007828	uridine monophosphate binding site [chemical binding]; other site
395491007829	homohexameric interface [polypeptide binding]; other site
395491007830	ribosome recycling factor; Reviewed; Region: frr; PRK00083
395491007831	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
395491007832	hinge region; other site
395491007833	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
395491007834	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
395491007835	catalytic residue [active]
395491007836	putative FPP diphosphate  binding site; other site
395491007837	putative FPP binding hydrophobic cleft; other site
395491007838	dimer interface [polypeptide binding]; other site
395491007839	putative IPP diphosphate binding site; other site
395491007840	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
395491007841	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
395491007842	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
395491007843	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
395491007844	active site
395491007845	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
395491007846	protein binding site [polypeptide binding]; other site
395491007847	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
395491007848	putative substrate binding region [chemical binding]; other site
395491007849	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
395491007850	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395491007851	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395491007852	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395491007853	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395491007854	Surface antigen; Region: Bac_surface_Ag; pfam01103
395491007855	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
395491007856	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
395491007857	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
395491007858	trimer interface [polypeptide binding]; other site
395491007859	active site
395491007860	UDP-GlcNAc binding site [chemical binding]; other site
395491007861	lipid binding site [chemical binding]; lipid-binding site
395491007862	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
395491007863	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
395491007864	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
395491007865	active site
395491007866	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
395491007867	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
395491007868	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
395491007869	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
395491007870	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
395491007871	dimer interface [polypeptide binding]; other site
395491007872	active site
395491007873	citrylCoA binding site [chemical binding]; other site
395491007874	NADH binding [chemical binding]; other site
395491007875	cationic pore residues; other site
395491007876	oxalacetate/citrate binding site [chemical binding]; other site
395491007877	coenzyme A binding site [chemical binding]; other site
395491007878	catalytic triad [active]
395491007879	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
395491007880	Competence protein; Region: Competence; pfam03772
395491007881	LexA repressor; Validated; Region: PRK00215
395491007882	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
395491007883	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
395491007884	Catalytic site [active]
395491007885	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
395491007886	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
395491007887	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
395491007888	enolase; Provisional; Region: eno; PRK00077
395491007889	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
395491007890	dimer interface [polypeptide binding]; other site
395491007891	metal binding site [ion binding]; metal-binding site
395491007892	substrate binding pocket [chemical binding]; other site
395491007893	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
395491007894	Septum formation initiator; Region: DivIC; pfam04977
395491007895	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
395491007896	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
395491007897	tetramer interface [polypeptide binding]; other site
395491007898	TPP-binding site [chemical binding]; other site
395491007899	heterodimer interface [polypeptide binding]; other site
395491007900	phosphorylation loop region [posttranslational modification]
395491007901	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
395491007902	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395491007903	E3 interaction surface; other site
395491007904	lipoyl attachment site [posttranslational modification]; other site
395491007905	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
395491007906	alpha subunit interface [polypeptide binding]; other site
395491007907	TPP binding site [chemical binding]; other site
395491007908	heterodimer interface [polypeptide binding]; other site
395491007909	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395491007910	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395491007911	E3 interaction surface; other site
395491007912	lipoyl attachment site [posttranslational modification]; other site
395491007913	e3 binding domain; Region: E3_binding; pfam02817
395491007914	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
395491007915	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
395491007916	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
395491007917	active site
395491007918	catalytic triad [active]
395491007919	oxyanion hole [active]
395491007920	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
395491007921	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
395491007922	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395491007923	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395491007924	Predicted membrane protein [Function unknown]; Region: COG2261
395491007925	lipoyl synthase; Provisional; Region: PRK05481
395491007926	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395491007927	FeS/SAM binding site; other site
395491007928	topology modulation protein; Reviewed; Region: PRK08118
395491007929	AAA domain; Region: AAA_17; pfam13207
395491007930	topology modulation protein; Reviewed; Region: PRK08118
395491007931	AAA domain; Region: AAA_17; pfam13207
395491007932	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
395491007933	putative coenzyme Q binding site [chemical binding]; other site
395491007934	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
395491007935	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
395491007936	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
395491007937	substrate binding site; other site
395491007938	dimer interface; other site
395491007939	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
395491007940	homotrimer interaction site [polypeptide binding]; other site
395491007941	zinc binding site [ion binding]; other site
395491007942	CDP-binding sites; other site
395491007943	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
395491007944	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
395491007945	FMN binding site [chemical binding]; other site
395491007946	active site
395491007947	catalytic residues [active]
395491007948	substrate binding site [chemical binding]; other site
395491007949	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395491007950	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491007951	dimer interface [polypeptide binding]; other site
395491007952	phosphorylation site [posttranslational modification]
395491007953	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491007954	ATP binding site [chemical binding]; other site
395491007955	Mg2+ binding site [ion binding]; other site
395491007956	G-X-G motif; other site
395491007957	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
395491007958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491007959	active site
395491007960	phosphorylation site [posttranslational modification]
395491007961	intermolecular recognition site; other site
395491007962	dimerization interface [polypeptide binding]; other site
395491007963	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491007964	Walker A motif; other site
395491007965	ATP binding site [chemical binding]; other site
395491007966	Walker B motif; other site
395491007967	arginine finger; other site
395491007968	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
395491007969	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
395491007970	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491007971	active site
395491007972	catalytic tetrad [active]
395491007973	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
395491007974	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491007975	dimerization interface [polypeptide binding]; other site
395491007976	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491007977	dimer interface [polypeptide binding]; other site
395491007978	phosphorylation site [posttranslational modification]
395491007979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491007980	ATP binding site [chemical binding]; other site
395491007981	Mg2+ binding site [ion binding]; other site
395491007982	G-X-G motif; other site
395491007983	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
395491007984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491007985	active site
395491007986	phosphorylation site [posttranslational modification]
395491007987	intermolecular recognition site; other site
395491007988	dimerization interface [polypeptide binding]; other site
395491007989	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491007990	Walker A motif; other site
395491007991	ATP binding site [chemical binding]; other site
395491007992	Walker B motif; other site
395491007993	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395491007994	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
395491007995	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
395491007996	homodimer interface [polypeptide binding]; other site
395491007997	substrate-cofactor binding pocket; other site
395491007998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491007999	catalytic residue [active]
395491008000	bacterial Hfq-like; Region: Hfq; cd01716
395491008001	hexamer interface [polypeptide binding]; other site
395491008002	Sm1 motif; other site
395491008003	RNA binding site [nucleotide binding]; other site
395491008004	Sm2 motif; other site
395491008005	GTPases [General function prediction only]; Region: HflX; COG2262
395491008006	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
395491008007	HflX GTPase family; Region: HflX; cd01878
395491008008	G1 box; other site
395491008009	GTP/Mg2+ binding site [chemical binding]; other site
395491008010	Switch I region; other site
395491008011	G2 box; other site
395491008012	G3 box; other site
395491008013	Switch II region; other site
395491008014	G4 box; other site
395491008015	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
395491008016	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
395491008017	homodimer interface [polypeptide binding]; other site
395491008018	metal binding site [ion binding]; metal-binding site
395491008019	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
395491008020	homodimer interface [polypeptide binding]; other site
395491008021	active site
395491008022	putative chemical substrate binding site [chemical binding]; other site
395491008023	metal binding site [ion binding]; metal-binding site
395491008024	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
395491008025	nucleoside/Zn binding site; other site
395491008026	dimer interface [polypeptide binding]; other site
395491008027	catalytic motif [active]
395491008028	siroheme synthase; Provisional; Region: cysG; PRK10637
395491008029	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
395491008030	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
395491008031	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
395491008032	active site
395491008033	SAM binding site [chemical binding]; other site
395491008034	homodimer interface [polypeptide binding]; other site
395491008035	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
395491008036	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
395491008037	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395491008038	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395491008039	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749
395491008040	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
395491008041	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491008042	Predicted permeases [General function prediction only]; Region: COG0679
395491008043	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395491008044	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
395491008045	classical (c) SDRs; Region: SDR_c; cd05233
395491008046	NAD(P) binding site [chemical binding]; other site
395491008047	active site
395491008048	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395491008049	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491008050	Walker A/P-loop; other site
395491008051	ATP binding site [chemical binding]; other site
395491008052	Q-loop/lid; other site
395491008053	ABC transporter signature motif; other site
395491008054	Walker B; other site
395491008055	D-loop; other site
395491008056	H-loop/switch region; other site
395491008057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491008058	dimer interface [polypeptide binding]; other site
395491008059	conserved gate region; other site
395491008060	putative PBP binding loops; other site
395491008061	ABC-ATPase subunit interface; other site
395491008062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491008063	dimer interface [polypeptide binding]; other site
395491008064	conserved gate region; other site
395491008065	putative PBP binding loops; other site
395491008066	ABC-ATPase subunit interface; other site
395491008067	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491008068	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491008069	substrate binding pocket [chemical binding]; other site
395491008070	membrane-bound complex binding site; other site
395491008071	hinge residues; other site
395491008072	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
395491008073	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
395491008074	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491008075	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
395491008076	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395491008077	classical (c) SDRs; Region: SDR_c; cd05233
395491008078	NAD(P) binding site [chemical binding]; other site
395491008079	active site
395491008080	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
395491008081	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
395491008082	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
395491008083	hypothetical protein; Provisional; Region: PRK06834
395491008084	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491008085	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491008086	Protein of unknown function (DUF2956); Region: DUF2956; pfam11169
395491008087	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491008088	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
395491008089	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491008090	cyclase homology domain; Region: CHD; cd07302
395491008091	nucleotidyl binding site; other site
395491008092	metal binding site [ion binding]; metal-binding site
395491008093	dimer interface [polypeptide binding]; other site
395491008094	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491008095	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491008096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491008097	hypothetical protein; Provisional; Region: PRK06184
395491008098	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491008099	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491008100	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395491008101	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491008102	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491008103	putative DNA binding site [nucleotide binding]; other site
395491008104	putative Zn2+ binding site [ion binding]; other site
395491008105	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
395491008106	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
395491008107	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828
395491008108	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491008109	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491008110	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
395491008111	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
395491008112	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395491008113	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491008114	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491008115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491008116	dimer interface [polypeptide binding]; other site
395491008117	conserved gate region; other site
395491008118	putative PBP binding loops; other site
395491008119	ABC-ATPase subunit interface; other site
395491008120	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491008121	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491008122	dimer interface [polypeptide binding]; other site
395491008123	conserved gate region; other site
395491008124	putative PBP binding loops; other site
395491008125	ABC-ATPase subunit interface; other site
395491008126	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491008127	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491008128	Walker A/P-loop; other site
395491008129	ATP binding site [chemical binding]; other site
395491008130	Q-loop/lid; other site
395491008131	ABC transporter signature motif; other site
395491008132	Walker B; other site
395491008133	D-loop; other site
395491008134	H-loop/switch region; other site
395491008135	TOBE domain; Region: TOBE_2; pfam08402
395491008136	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395491008137	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491008138	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
395491008139	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491008140	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
395491008141	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491008142	putative active site [active]
395491008143	catalytic residue [active]
395491008144	D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312
395491008145	mannonate dehydratase; Region: uxuA; TIGR00695
395491008146	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491008147	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491008148	DNA-binding site [nucleotide binding]; DNA binding site
395491008149	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
395491008150	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491008151	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
395491008152	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491008153	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491008154	dimer interface [polypeptide binding]; other site
395491008155	conserved gate region; other site
395491008156	putative PBP binding loops; other site
395491008157	ABC-ATPase subunit interface; other site
395491008158	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
395491008159	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491008160	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491008161	dimer interface [polypeptide binding]; other site
395491008162	conserved gate region; other site
395491008163	putative PBP binding loops; other site
395491008164	ABC-ATPase subunit interface; other site
395491008165	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491008166	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491008167	Walker A/P-loop; other site
395491008168	ATP binding site [chemical binding]; other site
395491008169	Q-loop/lid; other site
395491008170	ABC transporter signature motif; other site
395491008171	Walker B; other site
395491008172	D-loop; other site
395491008173	H-loop/switch region; other site
395491008174	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491008175	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491008176	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491008177	Walker A/P-loop; other site
395491008178	ATP binding site [chemical binding]; other site
395491008179	Q-loop/lid; other site
395491008180	ABC transporter signature motif; other site
395491008181	Walker B; other site
395491008182	D-loop; other site
395491008183	H-loop/switch region; other site
395491008184	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491008185	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491008186	DNA binding site [nucleotide binding]
395491008187	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491008188	ligand binding site [chemical binding]; other site
395491008189	dimerization interface [polypeptide binding]; other site
395491008190	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491008191	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491008192	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491008193	dimer interface [polypeptide binding]; other site
395491008194	ABC-ATPase subunit interface; other site
395491008195	putative PBP binding loops; other site
395491008196	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491008197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491008198	dimer interface [polypeptide binding]; other site
395491008199	conserved gate region; other site
395491008200	putative PBP binding loops; other site
395491008201	ABC-ATPase subunit interface; other site
395491008202	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491008203	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491008204	Walker A/P-loop; other site
395491008205	ATP binding site [chemical binding]; other site
395491008206	Q-loop/lid; other site
395491008207	ABC transporter signature motif; other site
395491008208	Walker B; other site
395491008209	D-loop; other site
395491008210	H-loop/switch region; other site
395491008211	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491008212	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491008213	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
395491008214	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491008215	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395491008216	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395491008217	Walker A/P-loop; other site
395491008218	ATP binding site [chemical binding]; other site
395491008219	Q-loop/lid; other site
395491008220	ABC transporter signature motif; other site
395491008221	Walker B; other site
395491008222	D-loop; other site
395491008223	H-loop/switch region; other site
395491008224	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395491008225	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
395491008226	FtsX-like permease family; Region: FtsX; pfam02687
395491008227	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491008228	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395491008229	active site
395491008230	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491008231	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491008232	DNA-binding site [nucleotide binding]; DNA binding site
395491008233	FCD domain; Region: FCD; pfam07729
395491008234	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
395491008235	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
395491008236	FAD binding pocket [chemical binding]; other site
395491008237	FAD binding motif [chemical binding]; other site
395491008238	phosphate binding motif [ion binding]; other site
395491008239	beta-alpha-beta structure motif; other site
395491008240	NAD binding pocket [chemical binding]; other site
395491008241	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
395491008242	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
395491008243	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
395491008244	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
395491008245	NADP binding site [chemical binding]; other site
395491008246	dimer interface [polypeptide binding]; other site
395491008247	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
395491008248	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491008249	Walker A/P-loop; other site
395491008250	ATP binding site [chemical binding]; other site
395491008251	Q-loop/lid; other site
395491008252	ABC transporter signature motif; other site
395491008253	Walker B; other site
395491008254	D-loop; other site
395491008255	H-loop/switch region; other site
395491008256	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491008257	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491008258	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
395491008259	TM-ABC transporter signature motif; other site
395491008260	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491008261	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
395491008262	TM-ABC transporter signature motif; other site
395491008263	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
395491008264	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
395491008265	putative ligand binding site [chemical binding]; other site
395491008266	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491008267	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
395491008268	putative ligand binding site [chemical binding]; other site
395491008269	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491008270	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491008271	Walker A/P-loop; other site
395491008272	ATP binding site [chemical binding]; other site
395491008273	Q-loop/lid; other site
395491008274	ABC transporter signature motif; other site
395491008275	Walker B; other site
395491008276	D-loop; other site
395491008277	H-loop/switch region; other site
395491008278	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491008279	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491008280	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491008281	TM-ABC transporter signature motif; other site
395491008282	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491008283	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491008284	TM-ABC transporter signature motif; other site
395491008285	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491008286	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491008287	DNA-binding site [nucleotide binding]; DNA binding site
395491008288	FCD domain; Region: FCD; pfam07729
395491008289	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
395491008290	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
395491008291	Substrate binding site; other site
395491008292	Mg++ binding site; other site
395491008293	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
395491008294	active site
395491008295	substrate binding site [chemical binding]; other site
395491008296	CoA binding site [chemical binding]; other site
395491008297	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
395491008298	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
395491008299	glutaminase active site [active]
395491008300	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
395491008301	dimer interface [polypeptide binding]; other site
395491008302	active site
395491008303	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
395491008304	dimer interface [polypeptide binding]; other site
395491008305	active site
395491008306	Uncharacterized conserved protein [Function unknown]; Region: COG2928
395491008307	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
395491008308	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
395491008309	generic binding surface II; other site
395491008310	ssDNA binding site; other site
395491008311	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395491008312	ATP binding site [chemical binding]; other site
395491008313	putative Mg++ binding site [ion binding]; other site
395491008314	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491008315	nucleotide binding region [chemical binding]; other site
395491008316	ATP-binding site [chemical binding]; other site
395491008317	Uncharacterized conserved protein [Function unknown]; Region: COG2938
395491008318	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
395491008319	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
395491008320	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395491008321	ATP binding site [chemical binding]; other site
395491008322	putative Mg++ binding site [ion binding]; other site
395491008323	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491008324	nucleotide binding region [chemical binding]; other site
395491008325	ATP-binding site [chemical binding]; other site
395491008326	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
395491008327	OsmC-like protein; Region: OsmC; cl00767
395491008328	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
395491008329	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
395491008330	catalytic residues [active]
395491008331	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
395491008332	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
395491008333	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
395491008334	Uncharacterized conserved protein [Function unknown]; Region: COG3785
395491008335	glutamine synthetase; Provisional; Region: glnA; PRK09469
395491008336	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
395491008337	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395491008338	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
395491008339	Nitrogen regulatory protein P-II; Region: P-II; smart00938
395491008340	Uncharacterized conserved protein [Function unknown]; Region: COG0062
395491008341	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
395491008342	putative substrate binding site [chemical binding]; other site
395491008343	putative ATP binding site [chemical binding]; other site
395491008344	Protein of unknown function (DUF808); Region: DUF808; cl01002
395491008345	Protein of unknown function DUF72; Region: DUF72; pfam01904
395491008346	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491008347	Coenzyme A binding pocket [chemical binding]; other site
395491008348	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
395491008349	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
395491008350	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
395491008351	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
395491008352	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
395491008353	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
395491008354	dimer interface [polypeptide binding]; other site
395491008355	ssDNA binding site [nucleotide binding]; other site
395491008356	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395491008357	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
395491008358	DNA gyrase subunit A; Validated; Region: PRK05560
395491008359	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
395491008360	CAP-like domain; other site
395491008361	active site
395491008362	primary dimer interface [polypeptide binding]; other site
395491008363	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395491008364	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395491008365	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395491008366	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395491008367	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395491008368	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
395491008369	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
395491008370	active site
395491008371	(T/H)XGH motif; other site
395491008372	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
395491008373	active site
395491008374	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
395491008375	active site
395491008376	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
395491008377	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
395491008378	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
395491008379	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
395491008380	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395491008381	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
395491008382	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395491008383	dimer interface [polypeptide binding]; other site
395491008384	active site
395491008385	Predicted transcriptional regulators [Transcription]; Region: COG1733
395491008386	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395491008387	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
395491008388	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
395491008389	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
395491008390	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395491008391	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
395491008392	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
395491008393	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395491008394	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395491008395	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491008396	Coenzyme A binding pocket [chemical binding]; other site
395491008397	MarR family; Region: MarR_2; pfam12802
395491008398	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491008399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491008400	putative substrate translocation pore; other site
395491008401	agmatinase; Region: agmatinase; TIGR01230
395491008402	Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589
395491008403	oligomer interface [polypeptide binding]; other site
395491008404	active site
395491008405	Mn binding site [ion binding]; other site
395491008406	membrane protein; Provisional; Region: PRK14407
395491008407	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491008408	DNA binding site [nucleotide binding]
395491008409	Predicted integral membrane protein [Function unknown]; Region: COG5616
395491008410	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491008411	TPR motif; other site
395491008412	binding surface
395491008413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491008414	TPR motif; other site
395491008415	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
395491008416	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
395491008417	putative catalytic residues [active]
395491008418	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
395491008419	Double zinc ribbon; Region: DZR; pfam12773
395491008420	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
395491008421	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491008422	cyclase homology domain; Region: CHD; cd07302
395491008423	nucleotidyl binding site; other site
395491008424	metal binding site [ion binding]; metal-binding site
395491008425	dimer interface [polypeptide binding]; other site
395491008426	Predicted ATPase [General function prediction only]; Region: COG3899
395491008427	AAA ATPase domain; Region: AAA_16; pfam13191
395491008428	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491008429	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395491008430	TPR motif; other site
395491008431	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
395491008432	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395491008433	PYR/PP interface [polypeptide binding]; other site
395491008434	dimer interface [polypeptide binding]; other site
395491008435	TPP binding site [chemical binding]; other site
395491008436	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395491008437	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
395491008438	TPP-binding site [chemical binding]; other site
395491008439	dimer interface [polypeptide binding]; other site
395491008440	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491008441	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491008442	DNA binding site [nucleotide binding]
395491008443	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
395491008444	putative dimerization interface [polypeptide binding]; other site
395491008445	putative ligand binding site [chemical binding]; other site
395491008446	Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314
395491008447	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491008448	ligand binding site [chemical binding]; other site
395491008449	dimerization interface [polypeptide binding]; other site
395491008450	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491008451	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491008452	Walker A/P-loop; other site
395491008453	ATP binding site [chemical binding]; other site
395491008454	Q-loop/lid; other site
395491008455	ABC transporter signature motif; other site
395491008456	Walker B; other site
395491008457	D-loop; other site
395491008458	H-loop/switch region; other site
395491008459	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491008460	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491008461	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491008462	TM-ABC transporter signature motif; other site
395491008463	Winged helix-turn helix; Region: HTH_29; pfam13551
395491008464	Homeodomain-like domain; Region: HTH_32; pfam13565
395491008465	Integrase core domain; Region: rve; pfam00665
395491008466	Helix-turn-helix domain; Region: HTH_28; pfam13518
395491008467	Winged helix-turn helix; Region: HTH_29; pfam13551
395491008468	Homeodomain-like domain; Region: HTH_32; pfam13565
395491008469	Integrase core domain; Region: rve; pfam00665
395491008470	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
395491008471	Part of AAA domain; Region: AAA_19; pfam13245
395491008472	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
395491008473	AAA domain; Region: AAA_12; pfam13087
395491008474	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
395491008475	putative active site [active]
395491008476	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
395491008477	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395491008478	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395491008479	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491008480	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
395491008481	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491008482	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395491008483	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491008484	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491008485	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491008486	dimerization interface [polypeptide binding]; other site
395491008487	Protein of unknown function, DUF599; Region: DUF599; pfam04654
395491008488	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
395491008489	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
395491008490	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
395491008491	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
395491008492	putative active site [active]
395491008493	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491008494	PAS fold; Region: PAS_3; pfam08447
395491008495	putative active site [active]
395491008496	heme pocket [chemical binding]; other site
395491008497	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395491008498	Ligand Binding Site [chemical binding]; other site
395491008499	Predicted membrane protein [Function unknown]; Region: COG3174
395491008500	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
395491008501	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
395491008502	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
395491008503	putative hydrolase; Provisional; Region: PRK02113
395491008504	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
395491008505	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
395491008506	active site
395491008507	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
395491008508	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
395491008509	active site
395491008510	HIGH motif; other site
395491008511	KMSKS motif; other site
395491008512	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
395491008513	tRNA binding surface [nucleotide binding]; other site
395491008514	anticodon binding site; other site
395491008515	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395491008516	DNA polymerase III subunit delta'; Validated; Region: PRK09112
395491008517	AAA ATPase domain; Region: AAA_16; pfam13191
395491008518	DNA polymerase III subunit delta'; Validated; Region: PRK08485
395491008519	thymidylate kinase; Region: DTMP_kinase; TIGR00041
395491008520	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
395491008521	TMP-binding site; other site
395491008522	ATP-binding site [chemical binding]; other site
395491008523	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
395491008524	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
395491008525	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
395491008526	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
395491008527	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
395491008528	GYD domain; Region: GYD; pfam08734
395491008529	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491008530	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491008531	metal binding site [ion binding]; metal-binding site
395491008532	active site
395491008533	I-site; other site
395491008534	Uncharacterized conserved protein [Function unknown]; Region: COG3246
395491008535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491008536	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491008537	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491008538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491008539	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
395491008540	putative substrate binding pocket [chemical binding]; other site
395491008541	putative dimerization interface [polypeptide binding]; other site
395491008542	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
395491008543	PhnA protein; Region: PhnA; pfam03831
395491008544	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395491008545	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395491008546	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395491008547	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395491008548	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395491008549	Predicted membrane protein [Function unknown]; Region: COG2261
395491008550	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
395491008551	SurA N-terminal domain; Region: SurA_N_3; cl07813
395491008552	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
395491008553	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
395491008554	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
395491008555	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
395491008556	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
395491008557	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
395491008558	active site
395491008559	ribulose/triose binding site [chemical binding]; other site
395491008560	phosphate binding site [ion binding]; other site
395491008561	substrate (anthranilate) binding pocket [chemical binding]; other site
395491008562	product (indole) binding pocket [chemical binding]; other site
395491008563	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
395491008564	trimer interface [polypeptide binding]; other site
395491008565	dimer interface [polypeptide binding]; other site
395491008566	putative active site [active]
395491008567	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
395491008568	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
395491008569	dimer interface [polypeptide binding]; other site
395491008570	putative functional site; other site
395491008571	putative MPT binding site; other site
395491008572	Predicted methyltransferase [General function prediction only]; Region: COG3897
395491008573	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491008574	Coenzyme A binding pocket [chemical binding]; other site
395491008575	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
395491008576	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
395491008577	ATP binding site [chemical binding]; other site
395491008578	Mg++ binding site [ion binding]; other site
395491008579	motif III; other site
395491008580	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491008581	nucleotide binding region [chemical binding]; other site
395491008582	ATP-binding site [chemical binding]; other site
395491008583	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
395491008584	RNA binding site [nucleotide binding]; other site
395491008585	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
395491008586	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491008587	cyclase homology domain; Region: CHD; cd07302
395491008588	nucleotidyl binding site; other site
395491008589	metal binding site [ion binding]; metal-binding site
395491008590	dimer interface [polypeptide binding]; other site
395491008591	FecR protein; Region: FecR; pfam04773
395491008592	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
395491008593	dimer interface [polypeptide binding]; other site
395491008594	active site
395491008595	coenzyme A binding site [chemical binding]; other site
395491008596	citrylCoA binding site [chemical binding]; other site
395491008597	Citrate synthase; Region: Citrate_synt; pfam00285
395491008598	oxalacetate/citrate binding site [chemical binding]; other site
395491008599	catalytic triad [active]
395491008600	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
395491008601	dimer interface [polypeptide binding]; other site
395491008602	Citrate synthase; Region: Citrate_synt; pfam00285
395491008603	active site
395491008604	citrylCoA binding site [chemical binding]; other site
395491008605	oxalacetate/citrate binding site [chemical binding]; other site
395491008606	coenzyme A binding site [chemical binding]; other site
395491008607	catalytic triad [active]
395491008608	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
395491008609	putative hydrophobic ligand binding site [chemical binding]; other site
395491008610	CTP synthetase; Validated; Region: pyrG; PRK05380
395491008611	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
395491008612	Catalytic site [active]
395491008613	active site
395491008614	UTP binding site [chemical binding]; other site
395491008615	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
395491008616	active site
395491008617	putative oxyanion hole; other site
395491008618	catalytic triad [active]
395491008619	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
395491008620	triosephosphate isomerase; Provisional; Region: PRK14565
395491008621	substrate binding site [chemical binding]; other site
395491008622	dimer interface [polypeptide binding]; other site
395491008623	catalytic triad [active]
395491008624	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395491008625	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
395491008626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491008627	Mg2+ binding site [ion binding]; other site
395491008628	G-X-G motif; other site
395491008629	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
395491008630	anchoring element; other site
395491008631	dimer interface [polypeptide binding]; other site
395491008632	ATP binding site [chemical binding]; other site
395491008633	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
395491008634	active site
395491008635	metal binding site [ion binding]; metal-binding site
395491008636	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
395491008637	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395491008638	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
395491008639	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
395491008640	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395491008641	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395491008642	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491008643	Coenzyme A binding pocket [chemical binding]; other site
395491008644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
395491008645	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
395491008646	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
395491008647	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
395491008648	putative FMN binding site [chemical binding]; other site
395491008649	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
395491008650	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
395491008651	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
395491008652	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
395491008653	active site
395491008654	dimer interface [polypeptide binding]; other site
395491008655	motif 1; other site
395491008656	motif 2; other site
395491008657	motif 3; other site
395491008658	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
395491008659	anticodon binding site; other site
395491008660	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395491008661	Sel1-like repeats; Region: SEL1; smart00671
395491008662	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395491008663	Sel1-like repeats; Region: SEL1; smart00671
395491008664	Sel1 repeat; Region: Sel1; pfam08238
395491008665	Sel1-like repeats; Region: SEL1; smart00671
395491008666	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395491008667	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491008668	TPR motif; other site
395491008669	binding surface
395491008670	Sel1-like repeats; Region: SEL1; smart00671
395491008671	Sel1-like repeats; Region: SEL1; smart00671
395491008672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
395491008673	hypothetical protein; Validated; Region: PRK00041
395491008674	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
395491008675	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
395491008676	trimerization site [polypeptide binding]; other site
395491008677	active site
395491008678	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
395491008679	GTP cyclohydrolase I; Provisional; Region: PLN03044
395491008680	active site
395491008681	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
395491008682	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395491008683	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
395491008684	active site
395491008685	nucleophile elbow; other site
395491008686	FOG: CBS domain [General function prediction only]; Region: COG0517
395491008687	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
395491008688	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
395491008689	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
395491008690	PAS domain; Region: PAS_5; pfam07310
395491008691	PilZ domain; Region: PilZ; pfam07238
395491008692	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
395491008693	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
395491008694	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
395491008695	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
395491008696	Sporulation related domain; Region: SPOR; pfam05036
395491008697	Uncharacterized conserved protein [Function unknown]; Region: COG5458
395491008698	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
395491008699	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
395491008700	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
395491008701	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
395491008702	putative dimer interface [polypeptide binding]; other site
395491008703	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491008704	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395491008705	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
395491008706	Predicted membrane protein [Function unknown]; Region: COG3821
395491008707	Predicted membrane protein [Function unknown]; Region: COG3503
395491008708	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
395491008709	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
395491008710	DNA binding residues [nucleotide binding]
395491008711	putative dimer interface [polypeptide binding]; other site
395491008712	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
395491008713	MgtE intracellular N domain; Region: MgtE_N; smart00924
395491008714	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
395491008715	Divalent cation transporter; Region: MgtE; cl00786
395491008716	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
395491008717	active site
395491008718	catalytic residues [active]
395491008719	metal binding site [ion binding]; metal-binding site
395491008720	BON domain; Region: BON; pfam04972
395491008721	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
395491008722	lipoate-protein ligase B; Provisional; Region: PRK14341
395491008723	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395491008724	EamA-like transporter family; Region: EamA; pfam00892
395491008725	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
395491008726	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395491008727	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395491008728	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
395491008729	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395491008730	carboxyltransferase (CT) interaction site; other site
395491008731	biotinylation site [posttranslational modification]; other site
395491008732	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
395491008733	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491008734	Coenzyme A binding pocket [chemical binding]; other site
395491008735	hypothetical protein; Validated; Region: PRK00124
395491008736	multidrug efflux system protein; Provisional; Region: PRK11431
395491008737	Predicted membrane protein [Function unknown]; Region: COG2259
395491008738	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
395491008739	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
395491008740	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
395491008741	Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387
395491008742	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
395491008743	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491008744	motif II; other site
395491008745	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
395491008746	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
395491008747	RNA binding surface [nucleotide binding]; other site
395491008748	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
395491008749	active site
395491008750	camphor resistance protein CrcB; Provisional; Region: PRK14195
395491008751	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
395491008752	Protein of unknown function (DUF461); Region: DUF461; pfam04314
395491008753	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
395491008754	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395491008755	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
395491008756	lipoyl attachment site [posttranslational modification]; other site
395491008757	glycine dehydrogenase; Provisional; Region: PRK05367
395491008758	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
395491008759	tetramer interface [polypeptide binding]; other site
395491008760	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491008761	catalytic residue [active]
395491008762	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
395491008763	tetramer interface [polypeptide binding]; other site
395491008764	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491008765	catalytic residue [active]
395491008766	oxidoreductase; Provisional; Region: PRK06196
395491008767	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
395491008768	putative NAD(P) binding site [chemical binding]; other site
395491008769	active site
395491008770	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491008771	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491008772	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
395491008773	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
395491008774	active site
395491008775	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
395491008776	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
395491008777	putative molybdopterin cofactor binding site [chemical binding]; other site
395491008778	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
395491008779	putative molybdopterin cofactor binding site; other site
395491008780	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
395491008781	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
395491008782	dimerization interface [polypeptide binding]; other site
395491008783	DPS ferroxidase diiron center [ion binding]; other site
395491008784	ion pore; other site
395491008785	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12632
395491008786	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
395491008787	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
395491008788	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
395491008789	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
395491008790	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
395491008791	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395491008792	catalytic residue [active]
395491008793	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
395491008794	FeS assembly protein SufD; Region: sufD; TIGR01981
395491008795	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
395491008796	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
395491008797	Walker A/P-loop; other site
395491008798	ATP binding site [chemical binding]; other site
395491008799	Q-loop/lid; other site
395491008800	ABC transporter signature motif; other site
395491008801	Walker B; other site
395491008802	D-loop; other site
395491008803	H-loop/switch region; other site
395491008804	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
395491008805	putative ABC transporter; Region: ycf24; CHL00085
395491008806	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
395491008807	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
395491008808	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395491008809	catalytic residue [active]
395491008810	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
395491008811	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395491008812	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395491008813	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395491008814	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
395491008815	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
395491008816	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
395491008817	active site
395491008818	HIGH motif; other site
395491008819	dimer interface [polypeptide binding]; other site
395491008820	KMSKS motif; other site
395491008821	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395491008822	RNA binding surface [nucleotide binding]; other site
395491008823	trehalose synthase; Region: treS_nterm; TIGR02456
395491008824	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
395491008825	active site
395491008826	catalytic site [active]
395491008827	Protein of unknown function; Region: DUF3971; pfam13116
395491008828	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
395491008829	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
395491008830	catalytic triad [active]
395491008831	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
395491008832	dinuclear metal binding motif [ion binding]; other site
395491008833	Synaptobrevin; Region: Synaptobrevin; pfam00957
395491008834	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
395491008835	Peptidase family M23; Region: Peptidase_M23; pfam01551
395491008836	helicase 45; Provisional; Region: PTZ00424
395491008837	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
395491008838	ATP binding site [chemical binding]; other site
395491008839	Mg++ binding site [ion binding]; other site
395491008840	motif III; other site
395491008841	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491008842	nucleotide binding region [chemical binding]; other site
395491008843	ATP-binding site [chemical binding]; other site
395491008844	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
395491008845	nudix motif; other site
395491008846	TfoX N-terminal domain; Region: TfoX_N; pfam04993
395491008847	Flavin Reductases; Region: FlaRed; cl00801
395491008848	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
395491008849	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
395491008850	ligand binding site [chemical binding]; other site
395491008851	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
395491008852	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
395491008853	substrate binding site [chemical binding]; other site
395491008854	hexamer interface [polypeptide binding]; other site
395491008855	metal binding site [ion binding]; metal-binding site
395491008856	Predicted secreted protein (DUF2259); Region: DUF2259; pfam10016
395491008857	adenylosuccinate lyase; Provisional; Region: PRK07492
395491008858	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
395491008859	tetramer interface [polypeptide binding]; other site
395491008860	active site
395491008861	Low affinity iron permease; Region: Iron_permease; cl12096
395491008862	Predicted integral membrane protein [Function unknown]; Region: COG5473
395491008863	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
395491008864	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491008865	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491008866	PAS fold; Region: PAS_3; pfam08447
395491008867	putative active site [active]
395491008868	heme pocket [chemical binding]; other site
395491008869	PAS fold; Region: PAS_3; pfam08447
395491008870	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491008871	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491008872	metal binding site [ion binding]; metal-binding site
395491008873	active site
395491008874	I-site; other site
395491008875	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491008876	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
395491008877	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
395491008878	ATP binding site [chemical binding]; other site
395491008879	active site
395491008880	substrate binding site [chemical binding]; other site
395491008881	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
395491008882	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
395491008883	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
395491008884	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
395491008885	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
395491008886	putative active site [active]
395491008887	catalytic triad [active]
395491008888	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
395491008889	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
395491008890	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491008891	DNA-binding site [nucleotide binding]; DNA binding site
395491008892	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491008893	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491008894	homodimer interface [polypeptide binding]; other site
395491008895	catalytic residue [active]
395491008896	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
395491008897	Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356
395491008898	substrate binding site [chemical binding]; other site
395491008899	Protein of unknown function (DUF521); Region: DUF521; pfam04412
395491008900	Putative Aconitase X catalytic domain; Region: AcnX; cd01355
395491008901	substrate binding site [chemical binding]; other site
395491008902	ligand binding site [chemical binding]; other site
395491008903	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
395491008904	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
395491008905	dimerization interface [polypeptide binding]; other site
395491008906	ATP binding site [chemical binding]; other site
395491008907	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
395491008908	dimerization interface [polypeptide binding]; other site
395491008909	ATP binding site [chemical binding]; other site
395491008910	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
395491008911	Cytochrome c; Region: Cytochrom_C; pfam00034
395491008912	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
395491008913	putative GSH binding site [chemical binding]; other site
395491008914	catalytic residues [active]
395491008915	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491008916	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
395491008917	putative substrate translocation pore; other site
395491008918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491008919	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
395491008920	putative substrate translocation pore; other site
395491008921	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
395491008922	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395491008923	active site
395491008924	putative lithium-binding site [ion binding]; other site
395491008925	substrate binding site [chemical binding]; other site
395491008926	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395491008927	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
395491008928	active site
395491008929	putative lithium-binding site [ion binding]; other site
395491008930	substrate binding site [chemical binding]; other site
395491008931	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
395491008932	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
395491008933	Ligand Binding Site [chemical binding]; other site
395491008934	TIGR00269 family protein; Region: TIGR00269
395491008935	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
395491008936	glutaminase; Provisional; Region: PRK00971
395491008937	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
395491008938	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
395491008939	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395491008940	RNA binding surface [nucleotide binding]; other site
395491008941	Domain of unknown function DUF87; Region: DUF87; pfam01935
395491008942	HerA helicase [Replication, recombination, and repair]; Region: COG0433
395491008943	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491008944	putative substrate translocation pore; other site
395491008945	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491008946	glutamate racemase; Provisional; Region: PRK00865
395491008947	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
395491008948	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
395491008949	Predicted membrane protein [Function unknown]; Region: COG1289
395491008950	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
395491008951	isocitrate dehydrogenase; Validated; Region: PRK08299
395491008952	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395491008953	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491008954	Coenzyme A binding pocket [chemical binding]; other site
395491008955	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491008956	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
395491008957	putative C-terminal domain interface [polypeptide binding]; other site
395491008958	putative GSH binding site (G-site) [chemical binding]; other site
395491008959	putative dimer interface [polypeptide binding]; other site
395491008960	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
395491008961	dimer interface [polypeptide binding]; other site
395491008962	N-terminal domain interface [polypeptide binding]; other site
395491008963	putative substrate binding pocket (H-site) [chemical binding]; other site
395491008964	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491008965	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491008966	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
395491008967	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
395491008968	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
395491008969	motif 1; other site
395491008970	active site
395491008971	motif 2; other site
395491008972	motif 3; other site
395491008973	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
395491008974	DHHA1 domain; Region: DHHA1; pfam02272
395491008975	recombinase A; Provisional; Region: recA; PRK09354
395491008976	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
395491008977	hexamer interface [polypeptide binding]; other site
395491008978	Walker A motif; other site
395491008979	ATP binding site [chemical binding]; other site
395491008980	Walker B motif; other site
395491008981	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491008982	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
395491008983	substrate binding site [chemical binding]; other site
395491008984	ATP binding site [chemical binding]; other site
395491008985	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
395491008986	Helix-turn-helix domain; Region: HTH_28; pfam13518
395491008987	Winged helix-turn helix; Region: HTH_29; pfam13551
395491008988	Homeodomain-like domain; Region: HTH_32; pfam13565
395491008989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
395491008990	Integrase core domain; Region: rve; pfam00665
395491008991	Integrase core domain; Region: rve_3; pfam13683
395491008992	PAS domain S-box; Region: sensory_box; TIGR00229
395491008993	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491008994	putative active site [active]
395491008995	heme pocket [chemical binding]; other site
395491008996	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
395491008997	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491008998	putative active site [active]
395491008999	heme pocket [chemical binding]; other site
395491009000	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395491009001	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491009002	dimer interface [polypeptide binding]; other site
395491009003	phosphorylation site [posttranslational modification]
395491009004	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491009005	ATP binding site [chemical binding]; other site
395491009006	Mg2+ binding site [ion binding]; other site
395491009007	G-X-G motif; other site
395491009008	Response regulator receiver domain; Region: Response_reg; pfam00072
395491009009	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491009010	active site
395491009011	phosphorylation site [posttranslational modification]
395491009012	intermolecular recognition site; other site
395491009013	dimerization interface [polypeptide binding]; other site
395491009014	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
395491009015	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
395491009016	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395491009017	catalytic core [active]
395491009018	YcjX-like family, DUF463; Region: DUF463; pfam04317
395491009019	Predicted membrane protein [Function unknown]; Region: COG3768
395491009020	Domain of unknown function (DUF697); Region: DUF697; cl12064
395491009021	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
395491009022	catalytic center binding site [active]
395491009023	ATP binding site [chemical binding]; other site
395491009024	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
395491009025	homooctamer interface [polypeptide binding]; other site
395491009026	active site
395491009027	dihydropteroate synthase; Region: DHPS; TIGR01496
395491009028	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
395491009029	substrate binding pocket [chemical binding]; other site
395491009030	dimer interface [polypeptide binding]; other site
395491009031	inhibitor binding site; inhibition site
395491009032	Bacterial protein of unknown function (DUF922); Region: DUF922; pfam06037
395491009033	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395491009034	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395491009035	catalytic loop [active]
395491009036	iron binding site [ion binding]; other site
395491009037	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
395491009038	putative binding surface; other site
395491009039	active site
395491009040	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
395491009041	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
395491009042	Isochorismatase family; Region: Isochorismatase; pfam00857
395491009043	catalytic triad [active]
395491009044	conserved cis-peptide bond; other site
395491009045	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395491009046	motif 1; other site
395491009047	dimer interface [polypeptide binding]; other site
395491009048	active site
395491009049	motif 2; other site
395491009050	motif 3; other site
395491009051	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
395491009052	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
395491009053	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395491009054	GAF domain; Region: GAF; pfam01590
395491009055	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491009056	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491009057	metal binding site [ion binding]; metal-binding site
395491009058	active site
395491009059	I-site; other site
395491009060	ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218
395491009061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
395491009062	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
395491009063	mce related protein; Region: MCE; pfam02470
395491009064	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
395491009065	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
395491009066	Walker A/P-loop; other site
395491009067	ATP binding site [chemical binding]; other site
395491009068	Q-loop/lid; other site
395491009069	ABC transporter signature motif; other site
395491009070	Walker B; other site
395491009071	D-loop; other site
395491009072	H-loop/switch region; other site
395491009073	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
395491009074	anti sigma factor interaction site; other site
395491009075	regulatory phosphorylation site [posttranslational modification]; other site
395491009076	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
395491009077	Permease; Region: Permease; pfam02405
395491009078	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
395491009079	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
395491009080	active site
395491009081	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491009082	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
395491009083	putative substrate translocation pore; other site
395491009084	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395491009085	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
395491009086	putative active site [active]
395491009087	putative metal binding site [ion binding]; other site
395491009088	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395491009089	catalytic core [active]
395491009090	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
395491009091	Protein export membrane protein; Region: SecD_SecF; cl14618
395491009092	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
395491009093	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491009094	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491009095	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491009096	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491009097	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
395491009098	FAD binding domain; Region: FAD_binding_4; pfam01565
395491009099	Berberine and berberine like; Region: BBE; pfam08031
395491009100	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491009101	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491009102	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491009103	putative effector binding pocket; other site
395491009104	dimerization interface [polypeptide binding]; other site
395491009105	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
395491009106	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
395491009107	malic enzyme; Reviewed; Region: PRK12862
395491009108	Malic enzyme, N-terminal domain; Region: malic; pfam00390
395491009109	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
395491009110	putative NAD(P) binding site [chemical binding]; other site
395491009111	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
395491009112	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
395491009113	RNA/DNA hybrid binding site [nucleotide binding]; other site
395491009114	active site
395491009115	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
395491009116	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491009117	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491009118	NAD(P) binding site [chemical binding]; other site
395491009119	active site
395491009120	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
395491009121	putative FMN binding site [chemical binding]; other site
395491009122	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491009123	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491009124	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491009125	dimerization interface [polypeptide binding]; other site
395491009126	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
395491009127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491009128	putative transporter; Provisional; Region: PRK10504
395491009129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491009130	putative substrate translocation pore; other site
395491009131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491009132	putative substrate translocation pore; other site
395491009133	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491009134	dimerization interface [polypeptide binding]; other site
395491009135	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491009136	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491009137	dimer interface [polypeptide binding]; other site
395491009138	putative CheW interface [polypeptide binding]; other site
395491009139	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
395491009140	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
395491009141	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
395491009142	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
395491009143	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
395491009144	NAD synthetase; Provisional; Region: PRK13981
395491009145	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
395491009146	multimer interface [polypeptide binding]; other site
395491009147	active site
395491009148	catalytic triad [active]
395491009149	protein interface 1 [polypeptide binding]; other site
395491009150	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
395491009151	homodimer interface [polypeptide binding]; other site
395491009152	NAD binding pocket [chemical binding]; other site
395491009153	ATP binding pocket [chemical binding]; other site
395491009154	Mg binding site [ion binding]; other site
395491009155	active-site loop [active]
395491009156	Predicted membrane protein [Function unknown]; Region: COG4420
395491009157	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
395491009158	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491009159	ligand binding site [chemical binding]; other site
395491009160	dimer interface [polypeptide binding]; other site
395491009161	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491009162	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491009163	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395491009164	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
395491009165	Walker A/P-loop; other site
395491009166	ATP binding site [chemical binding]; other site
395491009167	Q-loop/lid; other site
395491009168	ABC transporter signature motif; other site
395491009169	Walker B; other site
395491009170	D-loop; other site
395491009171	H-loop/switch region; other site
395491009172	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
395491009173	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
395491009174	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
395491009175	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
395491009176	glutathione reductase; Validated; Region: PRK06116
395491009177	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395491009178	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395491009179	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395491009180	acylphosphatase; Provisional; Region: PRK14425
395491009181	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184
395491009182	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
395491009183	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395491009184	active site
395491009185	dimer interface [polypeptide binding]; other site
395491009186	phosphoglycolate phosphatase; Provisional; Region: PRK13222
395491009187	Acid Phosphatase; Region: Acid_PPase; cl17256
395491009188	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491009189	motif II; other site
395491009190	Helix-turn-helix domain; Region: HTH_28; pfam13518
395491009191	Winged helix-turn helix; Region: HTH_29; pfam13551
395491009192	Homeodomain-like domain; Region: HTH_32; pfam13565
395491009193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
395491009194	Integrase core domain; Region: rve; pfam00665
395491009195	Integrase core domain; Region: rve_3; pfam13683
395491009196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
395491009197	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491009198	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491009199	fumarate hydratase; Reviewed; Region: fumC; PRK00485
395491009200	Class II fumarases; Region: Fumarase_classII; cd01362
395491009201	active site
395491009202	tetramer interface [polypeptide binding]; other site
395491009203	VCBS repeat; Region: VCBS_repeat; TIGR01965
395491009204	fumarate hydratase; Provisional; Region: PRK15389
395491009205	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
395491009206	Fumarase C-terminus; Region: Fumerase_C; pfam05683
395491009207	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491009208	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491009209	metal binding site [ion binding]; metal-binding site
395491009210	active site
395491009211	I-site; other site
395491009212	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
395491009213	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395491009214	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491009215	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491009216	MarR family; Region: MarR_2; pfam12802
395491009217	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
395491009218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
395491009219	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
395491009220	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395491009221	FeS/SAM binding site; other site
395491009222	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
395491009223	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395491009224	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491009225	S-adenosylmethionine binding site [chemical binding]; other site
395491009226	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
395491009227	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
395491009228	putative ligand binding residues [chemical binding]; other site
395491009229	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
395491009230	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491009231	ABC-ATPase subunit  interface; other site
395491009232	dimer interface [polypeptide binding]; other site
395491009233	putative PBP binding regions; other site
395491009234	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
395491009235	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
395491009236	Walker A/P-loop; other site
395491009237	ATP binding site [chemical binding]; other site
395491009238	Q-loop/lid; other site
395491009239	ABC transporter signature motif; other site
395491009240	Walker B; other site
395491009241	D-loop; other site
395491009242	H-loop/switch region; other site
395491009243	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
395491009244	MarR family; Region: MarR_2; pfam12802
395491009245	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
395491009246	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
395491009247	bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791
395491009248	N- and C-terminal domain interface [polypeptide binding]; other site
395491009249	active site
395491009250	MgATP binding site [chemical binding]; other site
395491009251	catalytic site [active]
395491009252	metal binding site [ion binding]; metal-binding site
395491009253	putative homotetramer interface [polypeptide binding]; other site
395491009254	putative homodimer interface [polypeptide binding]; other site
395491009255	glycerol binding site [chemical binding]; other site
395491009256	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
395491009257	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
395491009258	PYR/PP interface [polypeptide binding]; other site
395491009259	dimer interface [polypeptide binding]; other site
395491009260	TPP binding site [chemical binding]; other site
395491009261	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395491009262	transketolase; Reviewed; Region: PRK05899
395491009263	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
395491009264	TPP-binding site [chemical binding]; other site
395491009265	dimer interface [polypeptide binding]; other site
395491009266	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491009267	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491009268	TM-ABC transporter signature motif; other site
395491009269	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491009270	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
395491009271	ligand binding site [chemical binding]; other site
395491009272	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491009273	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491009274	Walker A/P-loop; other site
395491009275	ATP binding site [chemical binding]; other site
395491009276	Q-loop/lid; other site
395491009277	ABC transporter signature motif; other site
395491009278	Walker B; other site
395491009279	D-loop; other site
395491009280	H-loop/switch region; other site
395491009281	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491009282	short chain dehydrogenase; Provisional; Region: PRK06114
395491009283	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491009284	NAD(P) binding site [chemical binding]; other site
395491009285	active site
395491009286	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491009287	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491009288	NAD(P) binding site [chemical binding]; other site
395491009289	active site
395491009290	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
395491009291	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
395491009292	short chain dehydrogenase; Provisional; Region: PRK07478
395491009293	classical (c) SDRs; Region: SDR_c; cd05233
395491009294	NAD(P) binding site [chemical binding]; other site
395491009295	active site
395491009296	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395491009297	EamA-like transporter family; Region: EamA; cl17759
395491009298	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
395491009299	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
395491009300	GTP binding site; other site
395491009301	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
395491009302	Walker A motif; other site
395491009303	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491009304	PAS fold; Region: PAS_3; pfam08447
395491009305	putative active site [active]
395491009306	heme pocket [chemical binding]; other site
395491009307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491009308	ATP binding site [chemical binding]; other site
395491009309	G-X-G motif; other site
395491009310	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491009311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491009312	active site
395491009313	phosphorylation site [posttranslational modification]
395491009314	intermolecular recognition site; other site
395491009315	dimerization interface [polypeptide binding]; other site
395491009316	circadian clock protein KaiC; Reviewed; Region: PRK09302
395491009317	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395491009318	Walker A motif; other site
395491009319	ATP binding site [chemical binding]; other site
395491009320	Walker B motif; other site
395491009321	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
395491009322	Walker A motif; other site
395491009323	ATP binding site [chemical binding]; other site
395491009324	Walker B motif; other site
395491009325	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491009326	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491009327	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395491009328	putative effector binding pocket; other site
395491009329	putative dimerization interface [polypeptide binding]; other site
395491009330	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
395491009331	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491009332	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491009333	active site
395491009334	catalytic tetrad [active]
395491009335	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395491009336	maleylacetoacetate isomerase; Region: maiA; TIGR01262
395491009337	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395491009338	N-terminal domain interface [polypeptide binding]; other site
395491009339	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
395491009340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491009341	dimer interface [polypeptide binding]; other site
395491009342	phosphorylation site [posttranslational modification]
395491009343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491009344	ATP binding site [chemical binding]; other site
395491009345	Mg2+ binding site [ion binding]; other site
395491009346	G-X-G motif; other site
395491009347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491009348	osmolarity response regulator; Provisional; Region: ompR; PRK09468
395491009349	active site
395491009350	phosphorylation site [posttranslational modification]
395491009351	intermolecular recognition site; other site
395491009352	dimerization interface [polypeptide binding]; other site
395491009353	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491009354	DNA binding site [nucleotide binding]
395491009355	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491009356	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
395491009357	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
395491009358	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
395491009359	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395491009360	catalytic residues [active]
395491009361	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491009362	Serine hydrolase; Region: Ser_hydrolase; cl17834
395491009363	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
395491009364	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
395491009365	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
395491009366	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
395491009367	intersubunit interface [polypeptide binding]; other site
395491009368	active site
395491009369	catalytic residue [active]
395491009370	Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111
395491009371	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395491009372	NAD(P) binding site [chemical binding]; other site
395491009373	catalytic residues [active]
395491009374	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
395491009375	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
395491009376	NAD(P) binding site [chemical binding]; other site
395491009377	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
395491009378	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
395491009379	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491009380	substrate binding site [chemical binding]; other site
395491009381	dimer interface [polypeptide binding]; other site
395491009382	ATP binding site [chemical binding]; other site
395491009383	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491009384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395491009385	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491009386	dimer interface [polypeptide binding]; other site
395491009387	ABC-ATPase subunit interface; other site
395491009388	putative PBP binding loops; other site
395491009389	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491009390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491009391	dimer interface [polypeptide binding]; other site
395491009392	conserved gate region; other site
395491009393	putative PBP binding loops; other site
395491009394	ABC-ATPase subunit interface; other site
395491009395	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491009396	Src homology 2 (SH2) domain; Region: SH2; cl15255
395491009397	phosphotyrosine binding pocket [polypeptide binding]; other site
395491009398	hydrophobic binding pocket [polypeptide binding]; other site
395491009399	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491009400	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491009401	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491009402	Walker A/P-loop; other site
395491009403	ATP binding site [chemical binding]; other site
395491009404	Q-loop/lid; other site
395491009405	ABC transporter signature motif; other site
395491009406	Walker B; other site
395491009407	D-loop; other site
395491009408	H-loop/switch region; other site
395491009409	TOBE domain; Region: TOBE_2; pfam08402
395491009410	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
395491009411	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395491009412	ligand binding site [chemical binding]; other site
395491009413	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491009414	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491009415	substrate binding pocket [chemical binding]; other site
395491009416	membrane-bound complex binding site; other site
395491009417	hinge residues; other site
395491009418	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491009419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491009420	dimer interface [polypeptide binding]; other site
395491009421	conserved gate region; other site
395491009422	putative PBP binding loops; other site
395491009423	ABC-ATPase subunit interface; other site
395491009424	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491009425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491009426	dimer interface [polypeptide binding]; other site
395491009427	conserved gate region; other site
395491009428	putative PBP binding loops; other site
395491009429	ABC-ATPase subunit interface; other site
395491009430	Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425
395491009431	Predicted integral membrane protein [Function unknown]; Region: COG5530
395491009432	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
395491009433	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491009434	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491009435	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
395491009436	C-terminal domain interface [polypeptide binding]; other site
395491009437	GSH binding site (G-site) [chemical binding]; other site
395491009438	dimer interface [polypeptide binding]; other site
395491009439	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
395491009440	N-terminal domain interface [polypeptide binding]; other site
395491009441	dimer interface [polypeptide binding]; other site
395491009442	substrate binding pocket (H-site) [chemical binding]; other site
395491009443	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491009444	dimerization interface [polypeptide binding]; other site
395491009445	putative DNA binding site [nucleotide binding]; other site
395491009446	putative Zn2+ binding site [ion binding]; other site
395491009447	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900
395491009448	putative hydrophobic ligand binding site [chemical binding]; other site
395491009449	Uncharacterized conserved protein [Function unknown]; Region: COG5649
395491009450	Uncharacterized conserved protein [Function unknown]; Region: COG5649
395491009451	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
395491009452	putative hydrophobic ligand binding site [chemical binding]; other site
395491009453	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491009454	dimerization interface [polypeptide binding]; other site
395491009455	putative DNA binding site [nucleotide binding]; other site
395491009456	putative Zn2+ binding site [ion binding]; other site
395491009457	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395491009458	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395491009459	Walker A/P-loop; other site
395491009460	ATP binding site [chemical binding]; other site
395491009461	Q-loop/lid; other site
395491009462	ABC transporter signature motif; other site
395491009463	Walker B; other site
395491009464	D-loop; other site
395491009465	H-loop/switch region; other site
395491009466	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491009467	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491009468	dimer interface [polypeptide binding]; other site
395491009469	conserved gate region; other site
395491009470	putative PBP binding loops; other site
395491009471	ABC-ATPase subunit interface; other site
395491009472	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
395491009473	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
395491009474	active site
395491009475	dimer interface [polypeptide binding]; other site
395491009476	non-prolyl cis peptide bond; other site
395491009477	insertion regions; other site
395491009478	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395491009479	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491009480	membrane-bound complex binding site; other site
395491009481	hinge residues; other site
395491009482	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
395491009483	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395491009484	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
395491009485	A new structural DNA glycosylase; Region: AlkD_like; cd06561
395491009486	active site
395491009487	LysR family transcriptional regulator; Provisional; Region: PRK14997
395491009488	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491009489	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491009490	dimerization interface [polypeptide binding]; other site
395491009491	Porin subfamily; Region: Porin_2; pfam02530
395491009492	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491009493	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491009494	putative DNA binding site [nucleotide binding]; other site
395491009495	putative Zn2+ binding site [ion binding]; other site
395491009496	AsnC family; Region: AsnC_trans_reg; pfam01037
395491009497	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
395491009498	putative uracil binding site [chemical binding]; other site
395491009499	putative active site [active]
395491009500	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
395491009501	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
395491009502	Catalytic site; other site
395491009503	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491009504	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491009505	dimer interface [polypeptide binding]; other site
395491009506	phosphorylation site [posttranslational modification]
395491009507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491009508	ATP binding site [chemical binding]; other site
395491009509	Mg2+ binding site [ion binding]; other site
395491009510	G-X-G motif; other site
395491009511	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
395491009512	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
395491009513	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
395491009514	putative dimer interface [polypeptide binding]; other site
395491009515	active site pocket [active]
395491009516	putative cataytic base [active]
395491009517	cobalamin synthase; Reviewed; Region: cobS; PRK00235
395491009518	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
395491009519	Predicted aspartyl protease [General function prediction only]; Region: COG3577
395491009520	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
395491009521	catalytic motif [active]
395491009522	Catalytic residue [active]
395491009523	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491009524	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491009525	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395491009526	dimerization interface [polypeptide binding]; other site
395491009527	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
395491009528	short chain dehydrogenase; Provisional; Region: PRK07041
395491009529	putative NAD(P) binding site [chemical binding]; other site
395491009530	homodimer interface [polypeptide binding]; other site
395491009531	ABC-2 type transporter; Region: ABC2_membrane; cl17235
395491009532	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395491009533	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
395491009534	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
395491009535	Walker A/P-loop; other site
395491009536	ATP binding site [chemical binding]; other site
395491009537	Q-loop/lid; other site
395491009538	ABC transporter signature motif; other site
395491009539	Walker B; other site
395491009540	D-loop; other site
395491009541	H-loop/switch region; other site
395491009542	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
395491009543	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
395491009544	inhibitor binding site; inhibition site
395491009545	active site
395491009546	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491009547	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491009548	active site
395491009549	catalytic tetrad [active]
395491009550	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491009551	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491009552	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491009553	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
395491009554	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
395491009555	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
395491009556	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491009557	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491009558	Walker A/P-loop; other site
395491009559	ATP binding site [chemical binding]; other site
395491009560	Q-loop/lid; other site
395491009561	ABC transporter signature motif; other site
395491009562	Walker B; other site
395491009563	D-loop; other site
395491009564	H-loop/switch region; other site
395491009565	TOBE domain; Region: TOBE_2; pfam08402
395491009566	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491009567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491009568	dimer interface [polypeptide binding]; other site
395491009569	conserved gate region; other site
395491009570	putative PBP binding loops; other site
395491009571	ABC-ATPase subunit interface; other site
395491009572	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491009573	dimer interface [polypeptide binding]; other site
395491009574	conserved gate region; other site
395491009575	putative PBP binding loops; other site
395491009576	ABC-ATPase subunit interface; other site
395491009577	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491009578	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491009579	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491009580	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491009581	DNA binding site [nucleotide binding]
395491009582	domain linker motif; other site
395491009583	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
395491009584	ligand binding site [chemical binding]; other site
395491009585	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
395491009586	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
395491009587	HIGH motif; other site
395491009588	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
395491009589	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395491009590	active site
395491009591	KMSKS motif; other site
395491009592	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
395491009593	tRNA binding surface [nucleotide binding]; other site
395491009594	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491009595	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491009596	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
395491009597	putative dimerization interface [polypeptide binding]; other site
395491009598	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
395491009599	putative active site [active]
395491009600	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
395491009601	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
395491009602	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395491009603	Predicted ATPase [General function prediction only]; Region: COG3911
395491009604	AAA domain; Region: AAA_28; pfam13521
395491009605	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395491009606	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491009607	S-adenosylmethionine binding site [chemical binding]; other site
395491009608	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491009609	Coenzyme A binding pocket [chemical binding]; other site
395491009610	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491009611	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
395491009612	ligand binding site [chemical binding]; other site
395491009613	dimer interface [polypeptide binding]; other site
395491009614	Predicted amidohydrolase [General function prediction only]; Region: COG0388
395491009615	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
395491009616	active site
395491009617	catalytic triad [active]
395491009618	dimer interface [polypeptide binding]; other site
395491009619	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
395491009620	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395491009621	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
395491009622	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491009623	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
395491009624	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491009625	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
395491009626	PAS fold; Region: PAS_4; pfam08448
395491009627	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491009628	putative active site [active]
395491009629	heme pocket [chemical binding]; other site
395491009630	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
395491009631	putative acyl-acceptor binding pocket; other site
395491009632	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395491009633	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
395491009634	putative NAD(P) binding site [chemical binding]; other site
395491009635	structural Zn binding site [ion binding]; other site
395491009636	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
395491009637	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395491009638	dimer interface [polypeptide binding]; other site
395491009639	active site
395491009640	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
395491009641	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
395491009642	active site
395491009643	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764
395491009644	active site 2 [active]
395491009645	active site 1 [active]
395491009646	acyl carrier protein; Provisional; Region: PRK06508
395491009647	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491009648	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491009649	ligand binding site [chemical binding]; other site
395491009650	flexible hinge region; other site
395491009651	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395491009652	putative switch regulator; other site
395491009653	non-specific DNA interactions [nucleotide binding]; other site
395491009654	DNA binding site [nucleotide binding]
395491009655	sequence specific DNA binding site [nucleotide binding]; other site
395491009656	putative cAMP binding site [chemical binding]; other site
395491009657	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491009658	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
395491009659	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
395491009660	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491009661	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491009662	homodimer interface [polypeptide binding]; other site
395491009663	catalytic residue [active]
395491009664	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
395491009665	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
395491009666	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
395491009667	active site
395491009668	SAM binding site [chemical binding]; other site
395491009669	homodimer interface [polypeptide binding]; other site
395491009670	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
395491009671	active site
395491009672	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
395491009673	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
395491009674	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
395491009675	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395491009676	Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429
395491009677	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395491009678	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395491009679	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
395491009680	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
395491009681	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395491009682	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
395491009683	homotrimer interface [polypeptide binding]; other site
395491009684	Walker A motif; other site
395491009685	GTP binding site [chemical binding]; other site
395491009686	Walker B motif; other site
395491009687	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395491009688	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
395491009689	Cl- selectivity filter; other site
395491009690	Cl- binding residues [ion binding]; other site
395491009691	pore gating glutamate residue; other site
395491009692	dimer interface [polypeptide binding]; other site
395491009693	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395491009694	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491009695	cyclase homology domain; Region: CHD; cd07302
395491009696	nucleotidyl binding site; other site
395491009697	metal binding site [ion binding]; metal-binding site
395491009698	dimer interface [polypeptide binding]; other site
395491009699	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
395491009700	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
395491009701	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491009702	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491009703	DNA binding residues [nucleotide binding]
395491009704	dimerization interface [polypeptide binding]; other site
395491009705	gluconate 5-dehydrogenase; Provisional; Region: PRK06124
395491009706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491009707	NAD(P) binding site [chemical binding]; other site
395491009708	active site
395491009709	cobyric acid synthase; Provisional; Region: PRK00784
395491009710	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
395491009711	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
395491009712	catalytic triad [active]
395491009713	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
395491009714	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
395491009715	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491009716	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491009717	dimerization interface [polypeptide binding]; other site
395491009718	Lysine efflux permease [General function prediction only]; Region: COG1279
395491009719	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
395491009720	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491009721	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491009722	dimerization interface [polypeptide binding]; other site
395491009723	transcription elongation factor regulatory protein; Validated; Region: PRK06342
395491009724	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
395491009725	Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450
395491009726	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
395491009727	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
395491009728	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
395491009729	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
395491009730	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
395491009731	multidrug resistance protein MdtN; Provisional; Region: PRK10476
395491009732	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491009733	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491009734	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
395491009735	Predicted integral membrane protein [Function unknown]; Region: COG5616
395491009736	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395491009737	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491009738	TPR motif; other site
395491009739	binding surface
395491009740	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
395491009741	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395491009742	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395491009743	MarC family integral membrane protein; Region: MarC; cl00919
395491009744	DEAD-like helicases superfamily; Region: DEXDc; smart00487
395491009745	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395491009746	ATP binding site [chemical binding]; other site
395491009747	putative Mg++ binding site [ion binding]; other site
395491009748	helicase superfamily c-terminal domain; Region: HELICc; smart00490
395491009749	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395491009750	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
395491009751	conserved cys residue [active]
395491009752	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491009753	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491009754	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491009755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491009756	active site
395491009757	phosphorylation site [posttranslational modification]
395491009758	intermolecular recognition site; other site
395491009759	dimerization interface [polypeptide binding]; other site
395491009760	Response regulator receiver domain; Region: Response_reg; pfam00072
395491009761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491009762	active site
395491009763	phosphorylation site [posttranslational modification]
395491009764	intermolecular recognition site; other site
395491009765	dimerization interface [polypeptide binding]; other site
395491009766	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491009767	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491009768	metal binding site [ion binding]; metal-binding site
395491009769	active site
395491009770	I-site; other site
395491009771	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491009772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395491009773	active site
395491009774	phosphorylation site [posttranslational modification]
395491009775	intermolecular recognition site; other site
395491009776	dimerization interface [polypeptide binding]; other site
395491009777	Response regulator receiver domain; Region: Response_reg; pfam00072
395491009778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491009779	active site
395491009780	phosphorylation site [posttranslational modification]
395491009781	intermolecular recognition site; other site
395491009782	dimerization interface [polypeptide binding]; other site
395491009783	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491009784	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491009785	DinB family; Region: DinB; cl17821
395491009786	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491009787	putative DNA binding site [nucleotide binding]; other site
395491009788	putative Zn2+ binding site [ion binding]; other site
395491009789	Low molecular weight phosphatase family; Region: LMWPc; cd00115
395491009790	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
395491009791	active site
395491009792	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395491009793	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
395491009794	amphipathic channel; other site
395491009795	Asn-Pro-Ala signature motifs; other site
395491009796	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
395491009797	ArsC family; Region: ArsC; pfam03960
395491009798	catalytic residues [active]
395491009799	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
395491009800	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491009801	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491009802	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491009803	putative substrate translocation pore; other site
395491009804	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
395491009805	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395491009806	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
395491009807	Response regulator receiver domain; Region: Response_reg; pfam00072
395491009808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491009809	active site
395491009810	phosphorylation site [posttranslational modification]
395491009811	intermolecular recognition site; other site
395491009812	dimerization interface [polypeptide binding]; other site
395491009813	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395491009814	Histidine kinase; Region: HisKA_2; pfam07568
395491009815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491009816	ATP binding site [chemical binding]; other site
395491009817	Mg2+ binding site [ion binding]; other site
395491009818	G-X-G motif; other site
395491009819	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491009820	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491009821	putative substrate translocation pore; other site
395491009822	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491009823	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491009824	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491009825	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
395491009826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491009827	dimer interface [polypeptide binding]; other site
395491009828	conserved gate region; other site
395491009829	putative PBP binding loops; other site
395491009830	ABC-ATPase subunit interface; other site
395491009831	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491009832	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491009833	dimer interface [polypeptide binding]; other site
395491009834	conserved gate region; other site
395491009835	putative PBP binding loops; other site
395491009836	ABC-ATPase subunit interface; other site
395491009837	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491009838	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491009839	Walker A/P-loop; other site
395491009840	ATP binding site [chemical binding]; other site
395491009841	Q-loop/lid; other site
395491009842	ABC transporter signature motif; other site
395491009843	Walker B; other site
395491009844	D-loop; other site
395491009845	H-loop/switch region; other site
395491009846	TOBE domain; Region: TOBE_2; pfam08402
395491009847	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491009848	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491009849	Walker A/P-loop; other site
395491009850	ATP binding site [chemical binding]; other site
395491009851	Q-loop/lid; other site
395491009852	ABC transporter signature motif; other site
395491009853	Walker B; other site
395491009854	D-loop; other site
395491009855	H-loop/switch region; other site
395491009856	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
395491009857	dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361
395491009858	DAK2 domain; Region: Dak2; pfam02734
395491009859	DAK2 domain; Region: Dak2; cl03685
395491009860	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
395491009861	active site
395491009862	active pocket/dimerization site; other site
395491009863	phosphorylation site [posttranslational modification]
395491009864	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
395491009865	dimerization domain swap beta strand [polypeptide binding]; other site
395491009866	regulatory protein interface [polypeptide binding]; other site
395491009867	active site
395491009868	regulatory phosphorylation site [posttranslational modification]; other site
395491009869	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
395491009870	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
395491009871	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
395491009872	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
395491009873	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
395491009874	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
395491009875	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
395491009876	Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458
395491009877	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
395491009878	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491009879	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491009880	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491009881	Epoxide hydrolase N terminus; Region: EHN; pfam06441
395491009882	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491009883	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491009884	Serine hydrolase; Region: Ser_hydrolase; cl17834
395491009885	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491009886	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491009887	DNA-binding site [nucleotide binding]; DNA binding site
395491009888	FCD domain; Region: FCD; pfam07729
395491009889	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
395491009890	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491009891	S-adenosylmethionine binding site [chemical binding]; other site
395491009892	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
395491009893	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
395491009894	FAD binding pocket [chemical binding]; other site
395491009895	FAD binding motif [chemical binding]; other site
395491009896	phosphate binding motif [ion binding]; other site
395491009897	NAD binding pocket [chemical binding]; other site
395491009898	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
395491009899	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
395491009900	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
395491009901	conserved cys residue [active]
395491009902	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
395491009903	homotrimer interaction site [polypeptide binding]; other site
395491009904	putative active site [active]
395491009905	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491009906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491009907	dimer interface [polypeptide binding]; other site
395491009908	conserved gate region; other site
395491009909	putative PBP binding loops; other site
395491009910	ABC-ATPase subunit interface; other site
395491009911	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395491009912	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395491009913	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491009914	Walker A/P-loop; other site
395491009915	ATP binding site [chemical binding]; other site
395491009916	Q-loop/lid; other site
395491009917	ABC transporter signature motif; other site
395491009918	Walker B; other site
395491009919	D-loop; other site
395491009920	H-loop/switch region; other site
395491009921	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491009922	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491009923	substrate binding pocket [chemical binding]; other site
395491009924	membrane-bound complex binding site; other site
395491009925	hinge residues; other site
395491009926	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395491009927	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
395491009928	conserved cys residue [active]
395491009929	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491009930	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491009931	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491009932	MarR family; Region: MarR; pfam01047
395491009933	Epoxide hydrolase N terminus; Region: EHN; pfam06441
395491009934	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491009935	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
395491009936	active site
395491009937	8-oxo-dGMP binding site [chemical binding]; other site
395491009938	nudix motif; other site
395491009939	metal binding site [ion binding]; metal-binding site
395491009940	Protein of unknown function (DUF3095); Region: DUF3095; pfam11294
395491009941	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
395491009942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491009943	S-adenosylmethionine binding site [chemical binding]; other site
395491009944	CAP-Gly domain; Region: CAP_GLY; cl08315
395491009945	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
395491009946	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
395491009947	Cache domain; Region: Cache_2; pfam08269
395491009948	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491009949	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491009950	dimer interface [polypeptide binding]; other site
395491009951	putative CheW interface [polypeptide binding]; other site
395491009952	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
395491009953	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
395491009954	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
395491009955	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
395491009956	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491009957	catalytic site [active]
395491009958	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491009959	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491009960	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395491009961	putative effector binding pocket; other site
395491009962	putative dimerization interface [polypeptide binding]; other site
395491009963	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491009964	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491009965	active site
395491009966	catalytic tetrad [active]
395491009967	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
395491009968	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
395491009969	Protein of unknown function, DUF486; Region: DUF486; cl01236
395491009970	RDD family; Region: RDD; pfam06271
395491009971	putative sialic acid transporter; Region: 2A0112; TIGR00891
395491009972	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491009973	putative substrate translocation pore; other site
395491009974	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491009975	S-adenosylmethionine binding site [chemical binding]; other site
395491009976	Cupin; Region: Cupin_6; pfam12852
395491009977	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491009978	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491009979	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491009980	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
395491009981	classical (c) SDRs; Region: SDR_c; cd05233
395491009982	NAD(P) binding site [chemical binding]; other site
395491009983	active site
395491009984	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
395491009985	NmrA-like family; Region: NmrA; pfam05368
395491009986	NADP binding site [chemical binding]; other site
395491009987	active site
395491009988	regulatory binding site [polypeptide binding]; other site
395491009989	LysR family transcriptional regulator; Provisional; Region: PRK14997
395491009990	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491009991	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491009992	putative effector binding pocket; other site
395491009993	dimerization interface [polypeptide binding]; other site
395491009994	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
395491009995	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
395491009996	Sulfate transporter family; Region: Sulfate_transp; pfam00916
395491009997	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
395491009998	Response regulator receiver domain; Region: Response_reg; pfam00072
395491009999	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395491010000	active site
395491010001	phosphorylation site [posttranslational modification]
395491010002	intermolecular recognition site; other site
395491010003	dimerization interface [polypeptide binding]; other site
395491010004	Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172
395491010005	PLD-like domain; Region: PLDc_2; pfam13091
395491010006	putative active site [active]
395491010007	catalytic site [active]
395491010008	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
395491010009	PLD-like domain; Region: PLDc_2; pfam13091
395491010010	putative active site [active]
395491010011	catalytic site [active]
395491010012	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
395491010013	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395491010014	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
395491010015	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395491010016	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
395491010017	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491010018	cyclase homology domain; Region: CHD; cd07302
395491010019	nucleotidyl binding site; other site
395491010020	metal binding site [ion binding]; metal-binding site
395491010021	dimer interface [polypeptide binding]; other site
395491010022	Predicted integral membrane protein [Function unknown]; Region: COG5616
395491010023	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395491010024	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491010025	TPR motif; other site
395491010026	binding surface
395491010027	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491010028	binding surface
395491010029	TPR motif; other site
395491010030	Rhomboid family; Region: Rhomboid; pfam01694
395491010031	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491010032	cyclase homology domain; Region: CHD; cd07302
395491010033	nucleotidyl binding site; other site
395491010034	metal binding site [ion binding]; metal-binding site
395491010035	dimer interface [polypeptide binding]; other site
395491010036	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491010037	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
395491010038	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
395491010039	excinuclease ABC subunit B; Provisional; Region: PRK05298
395491010040	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395491010041	ATP binding site [chemical binding]; other site
395491010042	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491010043	nucleotide binding region [chemical binding]; other site
395491010044	ATP-binding site [chemical binding]; other site
395491010045	Ultra-violet resistance protein B; Region: UvrB; pfam12344
395491010046	UvrB/uvrC motif; Region: UVR; pfam02151
395491010047	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491010048	Coenzyme A binding pocket [chemical binding]; other site
395491010049	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
395491010050	Ca2+ binding site [ion binding]; other site
395491010051	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
395491010052	Ca2+ binding site [ion binding]; other site
395491010053	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
395491010054	Ca2+ binding site [ion binding]; other site
395491010055	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
395491010056	Ca2+ binding site [ion binding]; other site
395491010057	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
395491010058	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395491010059	DNA-binding site [nucleotide binding]; DNA binding site
395491010060	RNA-binding motif; other site
395491010061	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
395491010062	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
395491010063	FMN binding site [chemical binding]; other site
395491010064	active site
395491010065	catalytic residues [active]
395491010066	substrate binding site [chemical binding]; other site
395491010067	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395491010068	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395491010069	protein binding site [polypeptide binding]; other site
395491010070	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491010071	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395491010072	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
395491010073	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
395491010074	BA14K-like protein; Region: BA14K; pfam07886
395491010075	BA14K-like protein; Region: BA14K; pfam07886
395491010076	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395491010077	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
395491010078	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
395491010079	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491010080	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491010081	dimer interface [polypeptide binding]; other site
395491010082	phosphorylation site [posttranslational modification]
395491010083	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491010084	ATP binding site [chemical binding]; other site
395491010085	Mg2+ binding site [ion binding]; other site
395491010086	G-X-G motif; other site
395491010087	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491010088	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491010089	active site
395491010090	phosphorylation site [posttranslational modification]
395491010091	intermolecular recognition site; other site
395491010092	dimerization interface [polypeptide binding]; other site
395491010093	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491010094	DNA binding site [nucleotide binding]
395491010095	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491010096	Predicted flavoprotein [General function prediction only]; Region: COG0431
395491010097	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
395491010098	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491010099	Walker A/P-loop; other site
395491010100	ATP binding site [chemical binding]; other site
395491010101	Q-loop/lid; other site
395491010102	ABC transporter signature motif; other site
395491010103	Walker B; other site
395491010104	D-loop; other site
395491010105	H-loop/switch region; other site
395491010106	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
395491010107	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
395491010108	Predicted transcriptional regulators [Transcription]; Region: COG1733
395491010109	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395491010110	RibD C-terminal domain; Region: RibD_C; cl17279
395491010111	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491010112	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491010113	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
395491010114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491010115	S-adenosylmethionine binding site [chemical binding]; other site
395491010116	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491010117	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491010118	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491010119	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491010120	active site
395491010121	catalytic tetrad [active]
395491010122	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491010123	Coenzyme A binding pocket [chemical binding]; other site
395491010124	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491010125	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491010126	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
395491010127	dimerization interface [polypeptide binding]; other site
395491010128	substrate binding pocket [chemical binding]; other site
395491010129	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
395491010130	dimer interface [polypeptide binding]; other site
395491010131	short chain dehydrogenase; Provisional; Region: PRK07041
395491010132	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491010133	NAD(P) binding site [chemical binding]; other site
395491010134	active site
395491010135	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
395491010136	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491010137	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491010138	putative DNA binding site [nucleotide binding]; other site
395491010139	putative Zn2+ binding site [ion binding]; other site
395491010140	AsnC family; Region: AsnC_trans_reg; pfam01037
395491010141	argininosuccinate synthase; Provisional; Region: PRK13820
395491010142	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
395491010143	ANP binding site [chemical binding]; other site
395491010144	Substrate Binding Site II [chemical binding]; other site
395491010145	Substrate Binding Site I [chemical binding]; other site
395491010146	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491010147	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491010148	WHG domain; Region: WHG; pfam13305
395491010149	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
395491010150	Leucine carboxyl methyltransferase; Region: LCM; cl01306
395491010151	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
395491010152	Predicted periplasmic protein [Function unknown]; Region: COG3698
395491010153	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
395491010154	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395491010155	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491010156	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491010157	Walker A/P-loop; other site
395491010158	ATP binding site [chemical binding]; other site
395491010159	Q-loop/lid; other site
395491010160	ABC transporter signature motif; other site
395491010161	Walker B; other site
395491010162	D-loop; other site
395491010163	H-loop/switch region; other site
395491010164	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
395491010165	SnoaL-like domain; Region: SnoaL_3; pfam13474
395491010166	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491010167	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491010168	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
395491010169	substrate binding pocket [chemical binding]; other site
395491010170	dimerization interface [polypeptide binding]; other site
395491010171	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491010172	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
395491010173	dimer interface [polypeptide binding]; other site
395491010174	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395491010175	catalytic core [active]
395491010176	Predicted amidohydrolase [General function prediction only]; Region: COG0388
395491010177	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
395491010178	active site
395491010179	catalytic triad [active]
395491010180	dimer interface [polypeptide binding]; other site
395491010181	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491010182	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395491010183	active site
395491010184	metal binding site [ion binding]; metal-binding site
395491010185	dihydrodipicolinate reductase; Provisional; Region: PRK00048
395491010186	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
395491010187	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
395491010188	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
395491010189	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
395491010190	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
395491010191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491010192	Coenzyme A binding pocket [chemical binding]; other site
395491010193	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
395491010194	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395491010195	catalytic residue [active]
395491010196	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551
395491010197	active site
395491010198	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491010199	Coenzyme A binding pocket [chemical binding]; other site
395491010200	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491010201	S-adenosylmethionine binding site [chemical binding]; other site
395491010202	TIGR02594 family protein; Region: TIGR02594
395491010203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491010204	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491010205	putative substrate translocation pore; other site
395491010206	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
395491010207	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
395491010208	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
395491010209	putative active site [active]
395491010210	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
395491010211	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
395491010212	Moco binding site; other site
395491010213	metal coordination site [ion binding]; other site
395491010214	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
395491010215	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
395491010216	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
395491010217	RNA polymerase sigma factor; Provisional; Region: PRK12536
395491010218	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491010219	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
395491010220	DNA binding residues [nucleotide binding]
395491010221	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
395491010222	Right handed beta helix region; Region: Beta_helix; pfam13229
395491010223	Right handed beta helix region; Region: Beta_helix; pfam13229
395491010224	EamA-like transporter family; Region: EamA; pfam00892
395491010225	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
395491010226	EamA-like transporter family; Region: EamA; pfam00892
395491010227	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491010228	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491010229	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
395491010230	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
395491010231	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491010232	NAD(P) binding site [chemical binding]; other site
395491010233	active site
395491010234	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395491010235	FtsX-like permease family; Region: FtsX; pfam02687
395491010236	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395491010237	FtsX-like permease family; Region: FtsX; pfam02687
395491010238	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395491010239	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395491010240	Walker A/P-loop; other site
395491010241	ATP binding site [chemical binding]; other site
395491010242	Q-loop/lid; other site
395491010243	ABC transporter signature motif; other site
395491010244	Walker B; other site
395491010245	D-loop; other site
395491010246	H-loop/switch region; other site
395491010247	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395491010248	E3 interaction surface; other site
395491010249	lipoyl attachment site [posttranslational modification]; other site
395491010250	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491010251	Helix-turn-helix domain; Region: HTH_18; pfam12833
395491010252	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491010253	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491010254	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
395491010255	putative NAD(P) binding site [chemical binding]; other site
395491010256	active site
395491010257	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
395491010258	active site
395491010259	Dienelactone hydrolase family; Region: DLH; pfam01738
395491010260	hypothetical protein; Provisional; Region: PRK06834
395491010261	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491010262	Predicted small integral membrane protein [Function unknown]; Region: COG5605
395491010263	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864
395491010264	Subunit I/III interface [polypeptide binding]; other site
395491010265	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
395491010266	Subunit I/III interface [polypeptide binding]; other site
395491010267	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
395491010268	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
395491010269	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
395491010270	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
395491010271	Cytochrome c2 [Energy production and conversion]; Region: COG3474
395491010272	Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690
395491010273	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
395491010274	nucleotide binding site/active site [active]
395491010275	HIT family signature motif; other site
395491010276	catalytic residue [active]
395491010277	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
395491010278	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
395491010279	Walker A/P-loop; other site
395491010280	ATP binding site [chemical binding]; other site
395491010281	Q-loop/lid; other site
395491010282	ABC transporter signature motif; other site
395491010283	Walker B; other site
395491010284	D-loop; other site
395491010285	H-loop/switch region; other site
395491010286	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
395491010287	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491010288	ABC-ATPase subunit  interface; other site
395491010289	dimer interface [polypeptide binding]; other site
395491010290	putative PBP binding regions; other site
395491010291	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
395491010292	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
395491010293	putative ligand binding residues [chemical binding]; other site
395491010294	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
395491010295	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
395491010296	putative active site [active]
395491010297	Putative phosphatase (DUF442); Region: DUF442; cl17385
395491010298	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
395491010299	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
395491010300	Cupin; Region: Cupin_6; pfam12852
395491010301	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491010302	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491010303	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491010304	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491010305	putative active site [active]
395491010306	heme pocket [chemical binding]; other site
395491010307	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395491010308	HWE histidine kinase; Region: HWE_HK; pfam07536
395491010309	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491010310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491010311	active site
395491010312	phosphorylation site [posttranslational modification]
395491010313	intermolecular recognition site; other site
395491010314	dimerization interface [polypeptide binding]; other site
395491010315	Cupin domain; Region: Cupin_2; pfam07883
395491010316	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
395491010317	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491010318	AAA domain; Region: AAA_33; pfam13671
395491010319	AAA domain; Region: AAA_17; pfam13207
395491010320	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491010321	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491010322	active site
395491010323	catalytic tetrad [active]
395491010324	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491010325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491010326	active site
395491010327	phosphorylation site [posttranslational modification]
395491010328	intermolecular recognition site; other site
395491010329	dimerization interface [polypeptide binding]; other site
395491010330	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491010331	DNA binding site [nucleotide binding]
395491010332	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491010333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491010334	ATP binding site [chemical binding]; other site
395491010335	Mg2+ binding site [ion binding]; other site
395491010336	G-X-G motif; other site
395491010337	cell division protein FtsZ; Validated; Region: PRK09330
395491010338	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
395491010339	nucleotide binding site [chemical binding]; other site
395491010340	SulA interaction site; other site
395491010341	VCBS repeat; Region: VCBS_repeat; TIGR01965
395491010342	VCBS repeat; Region: VCBS_repeat; TIGR01965
395491010343	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491010344	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491010345	salt bridge; other site
395491010346	non-specific DNA binding site [nucleotide binding]; other site
395491010347	sequence-specific DNA binding site [nucleotide binding]; other site
395491010348	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
395491010349	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
395491010350	putative NAD(P) binding site [chemical binding]; other site
395491010351	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
395491010352	putative hydrophobic ligand binding site [chemical binding]; other site
395491010353	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
395491010354	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
395491010355	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
395491010356	potential catalytic triad [active]
395491010357	conserved cys residue [active]
395491010358	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
395491010359	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491010360	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491010361	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
395491010362	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
395491010363	L-ectoine synthase; Reviewed; Region: ectC; PRK13290
395491010364	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491010365	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491010366	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491010367	dimerization interface [polypeptide binding]; other site
395491010368	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491010369	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491010370	metal binding site [ion binding]; metal-binding site
395491010371	active site
395491010372	I-site; other site
395491010373	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491010374	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
395491010375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491010376	S-adenosylmethionine binding site [chemical binding]; other site
395491010377	Cache domain; Region: Cache_1; pfam02743
395491010378	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491010379	dimerization interface [polypeptide binding]; other site
395491010380	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
395491010381	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
395491010382	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
395491010383	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491010384	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
395491010385	anti sigma factor interaction site; other site
395491010386	regulatory phosphorylation site [posttranslational modification]; other site
395491010387	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
395491010388	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
395491010389	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
395491010390	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
395491010391	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491010392	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491010393	Walker A/P-loop; other site
395491010394	ATP binding site [chemical binding]; other site
395491010395	Q-loop/lid; other site
395491010396	ABC transporter signature motif; other site
395491010397	Walker B; other site
395491010398	D-loop; other site
395491010399	H-loop/switch region; other site
395491010400	TOBE domain; Region: TOBE_2; pfam08402
395491010401	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491010402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491010403	dimer interface [polypeptide binding]; other site
395491010404	conserved gate region; other site
395491010405	putative PBP binding loops; other site
395491010406	ABC-ATPase subunit interface; other site
395491010407	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
395491010408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491010409	dimer interface [polypeptide binding]; other site
395491010410	conserved gate region; other site
395491010411	putative PBP binding loops; other site
395491010412	ABC-ATPase subunit interface; other site
395491010413	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
395491010414	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491010415	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491010416	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
395491010417	nucleotide binding site [chemical binding]; other site
395491010418	Cupin domain; Region: Cupin_2; pfam07883
395491010419	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
395491010420	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
395491010421	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491010422	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395491010423	Uncharacterized conserved protein [Function unknown]; Region: COG2128
395491010424	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
395491010425	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
395491010426	active site
395491010427	catalytic site [active]
395491010428	substrate binding site [chemical binding]; other site
395491010429	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395491010430	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
395491010431	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491010432	DNA-binding site [nucleotide binding]; DNA binding site
395491010433	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491010434	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491010435	homodimer interface [polypeptide binding]; other site
395491010436	catalytic residue [active]
395491010437	Transposase; Region: DEDD_Tnp_IS110; pfam01548
395491010438	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
395491010439	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
395491010440	Response regulator receiver domain; Region: Response_reg; pfam00072
395491010441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491010442	active site
395491010443	phosphorylation site [posttranslational modification]
395491010444	intermolecular recognition site; other site
395491010445	dimerization interface [polypeptide binding]; other site
395491010446	CHASE4 domain; Region: CHASE4; pfam05228
395491010447	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491010448	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491010449	dimer interface [polypeptide binding]; other site
395491010450	phosphorylation site [posttranslational modification]
395491010451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491010452	ATP binding site [chemical binding]; other site
395491010453	Mg2+ binding site [ion binding]; other site
395491010454	G-X-G motif; other site
395491010455	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
395491010456	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491010457	Coenzyme A binding pocket [chemical binding]; other site
395491010458	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491010459	active site
395491010460	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
395491010461	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
395491010462	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
395491010463	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395491010464	active site
395491010465	metal binding site [ion binding]; metal-binding site
395491010466	RNA ligase; Region: RNA_ligase; pfam09414
395491010467	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
395491010468	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
395491010469	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
395491010470	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491010471	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491010472	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
395491010473	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491010474	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491010475	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491010476	putative effector binding pocket; other site
395491010477	dimerization interface [polypeptide binding]; other site
395491010478	H+ Antiporter protein; Region: 2A0121; TIGR00900
395491010479	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491010480	dimerization interface [polypeptide binding]; other site
395491010481	putative DNA binding site [nucleotide binding]; other site
395491010482	putative Zn2+ binding site [ion binding]; other site
395491010483	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491010484	cyclase homology domain; Region: CHD; cd07302
395491010485	nucleotidyl binding site; other site
395491010486	metal binding site [ion binding]; metal-binding site
395491010487	dimer interface [polypeptide binding]; other site
395491010488	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
395491010489	putative hydrophobic ligand binding site [chemical binding]; other site
395491010490	riboflavin synthase subunit beta; Provisional; Region: PRK12419
395491010491	active site
395491010492	homopentamer interface [polypeptide binding]; other site
395491010493	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491010494	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
395491010495	putative NAD(P) binding site [chemical binding]; other site
395491010496	putative active site [active]
395491010497	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491010498	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
395491010499	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491010500	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
395491010501	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
395491010502	CGNR zinc finger; Region: zf-CGNR; pfam11706
395491010503	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
395491010504	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491010505	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491010506	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491010507	The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484
395491010508	putative dimerization interface [polypeptide binding]; other site
395491010509	putative substrate binding pocket [chemical binding]; other site
395491010510	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
395491010511	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395491010512	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
395491010513	metal ion-dependent adhesion site (MIDAS); other site
395491010514	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491010515	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491010516	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491010517	putative effector binding pocket; other site
395491010518	dimerization interface [polypeptide binding]; other site
395491010519	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491010520	classical (c) SDRs; Region: SDR_c; cd05233
395491010521	NAD(P) binding site [chemical binding]; other site
395491010522	active site
395491010523	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
395491010524	homotrimer interaction site [polypeptide binding]; other site
395491010525	putative active site [active]
395491010526	FecR protein; Region: FecR; pfam04773
395491010527	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395491010528	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491010529	TPR motif; other site
395491010530	binding surface
395491010531	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491010532	TPR motif; other site
395491010533	binding surface
395491010534	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491010535	binding surface
395491010536	TPR motif; other site
395491010537	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395491010538	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
395491010539	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
395491010540	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
395491010541	cyclase homology domain; Region: CHD; cd07302
395491010542	nucleotidyl binding site; other site
395491010543	metal binding site [ion binding]; metal-binding site
395491010544	dimer interface [polypeptide binding]; other site
395491010545	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491010546	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491010547	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395491010548	dimerization interface [polypeptide binding]; other site
395491010549	EamA-like transporter family; Region: EamA; pfam00892
395491010550	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
395491010551	EamA-like transporter family; Region: EamA; pfam00892
395491010552	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395491010553	active site
395491010554	NTP binding site [chemical binding]; other site
395491010555	metal binding triad [ion binding]; metal-binding site
395491010556	antibiotic binding site [chemical binding]; other site
395491010557	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
395491010558	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
395491010559	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
395491010560	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
395491010561	trimer interface [polypeptide binding]; other site
395491010562	putative metal binding site [ion binding]; other site
395491010563	Transposase; Region: DEDD_Tnp_IS110; pfam01548
395491010564	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
395491010565	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
395491010566	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
395491010567	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
395491010568	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
395491010569	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395491010570	metal binding site 2 [ion binding]; metal-binding site
395491010571	putative DNA binding helix; other site
395491010572	metal binding site 1 [ion binding]; metal-binding site
395491010573	dimer interface [polypeptide binding]; other site
395491010574	structural Zn2+ binding site [ion binding]; other site
395491010575	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
395491010576	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491010577	ABC-ATPase subunit  interface; other site
395491010578	dimer interface [polypeptide binding]; other site
395491010579	putative PBP binding regions; other site
395491010580	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
395491010581	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
395491010582	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
395491010583	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
395491010584	metal binding site [ion binding]; metal-binding site
395491010585	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395491010586	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
395491010587	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
395491010588	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
395491010589	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395491010590	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491010591	active site
395491010592	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
395491010593	Domain of unknown function DUF21; Region: DUF21; pfam01595
395491010594	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
395491010595	Transporter associated domain; Region: CorC_HlyC; smart01091
395491010596	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
395491010597	Chromate transporter; Region: Chromate_transp; pfam02417
395491010598	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
395491010599	active site residue [active]
395491010600	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
395491010601	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
395491010602	NUDIX domain; Region: NUDIX; pfam00293
395491010603	nudix motif; other site
395491010604	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
395491010605	putative catalytic site [active]
395491010606	putative metal binding site [ion binding]; other site
395491010607	putative phosphate binding site [ion binding]; other site
395491010608	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
395491010609	putative metal binding site [ion binding]; other site
395491010610	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
395491010611	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491010612	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
395491010613	Walker A/P-loop; other site
395491010614	ATP binding site [chemical binding]; other site
395491010615	Q-loop/lid; other site
395491010616	ABC transporter signature motif; other site
395491010617	Walker B; other site
395491010618	D-loop; other site
395491010619	H-loop/switch region; other site
395491010620	TOBE domain; Region: TOBE_2; pfam08402
395491010621	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
395491010622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491010623	dimer interface [polypeptide binding]; other site
395491010624	conserved gate region; other site
395491010625	putative PBP binding loops; other site
395491010626	ABC-ATPase subunit interface; other site
395491010627	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491010628	dimer interface [polypeptide binding]; other site
395491010629	conserved gate region; other site
395491010630	putative PBP binding loops; other site
395491010631	ABC-ATPase subunit interface; other site
395491010632	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395491010633	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395491010634	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491010635	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395491010636	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
395491010637	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491010638	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491010639	active site
395491010640	catalytic tetrad [active]
395491010641	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
395491010642	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491010643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491010644	homodimer interface [polypeptide binding]; other site
395491010645	catalytic residue [active]
395491010646	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
395491010647	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
395491010648	homodimer interface [polypeptide binding]; other site
395491010649	substrate-cofactor binding pocket; other site
395491010650	catalytic residue [active]
395491010651	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
395491010652	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
395491010653	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
395491010654	putative active site [active]
395491010655	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
395491010656	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
395491010657	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395491010658	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491010659	S-adenosylmethionine binding site [chemical binding]; other site
395491010660	ketol-acid reductoisomerase; Provisional; Region: PRK05479
395491010661	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
395491010662	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
395491010663	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491010664	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491010665	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
395491010666	Protein of unknown function (DUF4087); Region: DUF4087; pfam13316
395491010667	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
395491010668	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
395491010669	Ligand binding site; other site
395491010670	Putative Catalytic site; other site
395491010671	DXD motif; other site
395491010672	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
395491010673	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395491010674	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
395491010675	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
395491010676	putative NAD(P) binding site [chemical binding]; other site
395491010677	putative substrate binding site [chemical binding]; other site
395491010678	catalytic Zn binding site [ion binding]; other site
395491010679	structural Zn binding site [ion binding]; other site
395491010680	dimer interface [polypeptide binding]; other site
395491010681	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
395491010682	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
395491010683	G1 box; other site
395491010684	GTP/Mg2+ binding site [chemical binding]; other site
395491010685	G2 box; other site
395491010686	Switch I region; other site
395491010687	G3 box; other site
395491010688	Switch II region; other site
395491010689	G4 box; other site
395491010690	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
395491010691	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
395491010692	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
395491010693	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
395491010694	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395491010695	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491010696	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491010697	putative DNA binding site [nucleotide binding]; other site
395491010698	putative Zn2+ binding site [ion binding]; other site
395491010699	AsnC family; Region: AsnC_trans_reg; pfam01037
395491010700	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
395491010701	aspartate racemase; Region: asp_race; TIGR00035
395491010702	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491010703	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491010704	putative DNA binding site [nucleotide binding]; other site
395491010705	putative Zn2+ binding site [ion binding]; other site
395491010706	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491010707	Coenzyme A binding pocket [chemical binding]; other site
395491010708	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491010709	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491010710	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
395491010711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491010712	Predicted transcriptional regulators [Transcription]; Region: COG1733
395491010713	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395491010714	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
395491010715	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
395491010716	NADP binding site [chemical binding]; other site
395491010717	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
395491010718	active site
395491010719	hydrophilic channel; other site
395491010720	dimerization interface [polypeptide binding]; other site
395491010721	catalytic residues [active]
395491010722	active site lid [active]
395491010723	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
395491010724	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
395491010725	dimer interface [polypeptide binding]; other site
395491010726	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491010727	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491010728	DNA binding residues [nucleotide binding]
395491010729	dimerization interface [polypeptide binding]; other site
395491010730	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
395491010731	AAA domain; Region: AAA_30; pfam13604
395491010732	Family description; Region: UvrD_C_2; pfam13538
395491010733	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491010734	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491010735	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491010736	putative effector binding pocket; other site
395491010737	dimerization interface [polypeptide binding]; other site
395491010738	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395491010739	Uncharacterized conserved protein [Function unknown]; Region: COG2128
395491010740	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491010741	NADH(P)-binding; Region: NAD_binding_10; pfam13460
395491010742	NAD(P) binding site [chemical binding]; other site
395491010743	active site
395491010744	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
395491010745	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395491010746	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395491010747	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491010748	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491010749	ligand binding site [chemical binding]; other site
395491010750	flexible hinge region; other site
395491010751	Predicted transcriptional regulator [Transcription]; Region: COG1959
395491010752	Transcriptional regulator; Region: Rrf2; pfam02082
395491010753	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491010754	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491010755	putative Zn2+ binding site [ion binding]; other site
395491010756	putative DNA binding site [nucleotide binding]; other site
395491010757	Cupin domain; Region: Cupin_2; pfam07883
395491010758	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
395491010759	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
395491010760	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
395491010761	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
395491010762	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491010763	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491010764	DNA binding residues [nucleotide binding]
395491010765	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
395491010766	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
395491010767	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
395491010768	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
395491010769	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
395491010770	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
395491010771	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
395491010772	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491010773	putative NAD(P) binding site [chemical binding]; other site
395491010774	active site
395491010775	DoxX-like family; Region: DoxX_3; pfam13781
395491010776	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
395491010777	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
395491010778	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491010779	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491010780	active site
395491010781	catalytic tetrad [active]
395491010782	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
395491010783	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
395491010784	putative valine binding site [chemical binding]; other site
395491010785	dimer interface [polypeptide binding]; other site
395491010786	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
395491010787	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
395491010788	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395491010789	PYR/PP interface [polypeptide binding]; other site
395491010790	dimer interface [polypeptide binding]; other site
395491010791	TPP binding site [chemical binding]; other site
395491010792	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395491010793	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
395491010794	TPP-binding site [chemical binding]; other site
395491010795	dimer interface [polypeptide binding]; other site
395491010796	HerA helicase [Replication, recombination, and repair]; Region: COG0433
395491010797	Domain of unknown function DUF87; Region: DUF87; pfam01935
395491010798	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491010799	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
395491010800	inhibitor site; inhibition site
395491010801	active site
395491010802	dimer interface [polypeptide binding]; other site
395491010803	catalytic residue [active]
395491010804	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
395491010805	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491010806	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
395491010807	DNA-binding site [nucleotide binding]; DNA binding site
395491010808	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491010809	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491010810	homodimer interface [polypeptide binding]; other site
395491010811	catalytic residue [active]
395491010812	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
395491010813	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
395491010814	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
395491010815	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491010816	motif II; other site
395491010817	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
395491010818	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395491010819	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395491010820	protein binding site [polypeptide binding]; other site
395491010821	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395491010822	protein binding site [polypeptide binding]; other site
395491010823	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
395491010824	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
395491010825	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
395491010826	HflK protein; Region: hflK; TIGR01933
395491010827	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
395491010828	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
395491010829	folate binding site [chemical binding]; other site
395491010830	NADP+ binding site [chemical binding]; other site
395491010831	thymidylate synthase; Reviewed; Region: thyA; PRK01827
395491010832	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
395491010833	dimerization interface [polypeptide binding]; other site
395491010834	active site
395491010835	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
395491010836	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
395491010837	Ribbon-helix-helix domain; Region: RHH_4; cl01775
395491010838	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
395491010839	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
395491010840	FAD binding domain; Region: FAD_binding_4; pfam01565
395491010841	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491010842	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491010843	active site
395491010844	catalytic tetrad [active]
395491010845	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491010846	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491010847	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491010848	dimerization interface [polypeptide binding]; other site
395491010849	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
395491010850	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
395491010851	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
395491010852	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
395491010853	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395491010854	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491010855	Protein of unknown function (DUF2000); Region: DUF2000; cl02074
395491010856	putative outer membrane lipoprotein; Provisional; Region: PRK10510
395491010857	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395491010858	ligand binding site [chemical binding]; other site
395491010859	flagellin; Reviewed; Region: PRK12687
395491010860	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395491010861	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395491010862	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395491010863	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395491010864	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491010865	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491010866	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491010867	cyclase homology domain; Region: CHD; cd07302
395491010868	nucleotidyl binding site; other site
395491010869	metal binding site [ion binding]; metal-binding site
395491010870	dimer interface [polypeptide binding]; other site
395491010871	SpoVR family protein; Provisional; Region: PRK11767
395491010872	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
395491010873	hypothetical protein; Provisional; Region: PRK05325
395491010874	PrkA family serine protein kinase; Provisional; Region: PRK15455
395491010875	AAA ATPase domain; Region: AAA_16; pfam13191
395491010876	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
395491010877	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
395491010878	dimer interface [polypeptide binding]; other site
395491010879	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
395491010880	Part of AAA domain; Region: AAA_19; pfam13245
395491010881	Family description; Region: UvrD_C_2; pfam13538
395491010882	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
395491010883	Ca2+ binding site [ion binding]; other site
395491010884	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
395491010885	Isochorismatase family; Region: Isochorismatase; pfam00857
395491010886	catalytic triad [active]
395491010887	metal binding site [ion binding]; metal-binding site
395491010888	conserved cis-peptide bond; other site
395491010889	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
395491010890	RibD C-terminal domain; Region: RibD_C; cl17279
395491010891	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
395491010892	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
395491010893	Predicted membrane protein [Function unknown]; Region: COG4541
395491010894	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
395491010895	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
395491010896	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
395491010897	active site
395491010898	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
395491010899	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491010900	S-adenosylmethionine binding site [chemical binding]; other site
395491010901	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
395491010902	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
395491010903	Cu(I) binding site [ion binding]; other site
395491010904	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
395491010905	putative CheA interaction surface; other site
395491010906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
395491010907	CreA protein; Region: CreA; pfam05981
395491010908	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
395491010909	active site
395491010910	catalytic site [active]
395491010911	substrate binding site [chemical binding]; other site
395491010912	putative acetyltransferase YhhY; Provisional; Region: PRK10140
395491010913	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491010914	Coenzyme A binding pocket [chemical binding]; other site
395491010915	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
395491010916	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
395491010917	nucleotide binding pocket [chemical binding]; other site
395491010918	K-X-D-G motif; other site
395491010919	catalytic site [active]
395491010920	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
395491010921	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
395491010922	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
395491010923	Dimer interface [polypeptide binding]; other site
395491010924	BRCT sequence motif; other site
395491010925	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
395491010926	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
395491010927	Walker A/P-loop; other site
395491010928	ATP binding site [chemical binding]; other site
395491010929	Q-loop/lid; other site
395491010930	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
395491010931	ABC transporter signature motif; other site
395491010932	Walker B; other site
395491010933	D-loop; other site
395491010934	H-loop/switch region; other site
395491010935	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
395491010936	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
395491010937	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
395491010938	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
395491010939	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
395491010940	nucleotide binding site [chemical binding]; other site
395491010941	SulA interaction site; other site
395491010942	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
395491010943	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
395491010944	Cell division protein FtsA; Region: FtsA; smart00842
395491010945	Cell division protein FtsA; Region: FtsA; pfam14450
395491010946	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
395491010947	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
395491010948	Cell division protein FtsQ; Region: FtsQ; pfam03799
395491010949	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
395491010950	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
395491010951	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395491010952	aquaporin Z; Provisional; Region: PRK05420
395491010953	amphipathic channel; other site
395491010954	Asn-Pro-Ala signature motifs; other site
395491010955	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491010956	metabolite-proton symporter; Region: 2A0106; TIGR00883
395491010957	putative substrate translocation pore; other site
395491010958	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491010959	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
395491010960	putative NAD(P) binding site [chemical binding]; other site
395491010961	active site
395491010962	putative substrate binding site [chemical binding]; other site
395491010963	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
395491010964	FAD binding domain; Region: FAD_binding_4; pfam01565
395491010965	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
395491010966	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
395491010967	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
395491010968	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395491010969	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395491010970	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
395491010971	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
395491010972	active site
395491010973	homodimer interface [polypeptide binding]; other site
395491010974	cell division protein FtsW; Region: ftsW; TIGR02614
395491010975	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
395491010976	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395491010977	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395491010978	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
395491010979	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
395491010980	Mg++ binding site [ion binding]; other site
395491010981	putative catalytic motif [active]
395491010982	putative substrate binding site [chemical binding]; other site
395491010983	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
395491010984	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
395491010985	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395491010986	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
395491010987	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395491010988	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395491010989	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
395491010990	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
395491010991	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395491010992	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
395491010993	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
395491010994	MraW methylase family; Region: Methyltransf_5; cl17771
395491010995	cell division protein MraZ; Reviewed; Region: PRK00326
395491010996	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
395491010997	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395491010998	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491010999	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395491011000	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395491011001	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395491011002	catalytic residue [active]
395491011003	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
395491011004	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
395491011005	amidase catalytic site [active]
395491011006	Zn binding residues [ion binding]; other site
395491011007	substrate binding site [chemical binding]; other site
395491011008	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491011009	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
395491011010	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
395491011011	putative metal binding site [ion binding]; other site
395491011012	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395491011013	HSP70 interaction site [polypeptide binding]; other site
395491011014	pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555
395491011015	6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205
395491011016	active site
395491011017	ADP/pyrophosphate binding site [chemical binding]; other site
395491011018	allosteric effector site; other site
395491011019	dimerization interface [polypeptide binding]; other site
395491011020	fructose-1,6-bisphosphate binding site; other site
395491011021	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
395491011022	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395491011023	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395491011024	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395491011025	catalytic residue [active]
395491011026	Beta-lactamase; Region: Beta-lactamase; pfam00144
395491011027	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395491011028	S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379
395491011029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491011030	S-adenosylmethionine binding site [chemical binding]; other site
395491011031	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
395491011032	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
395491011033	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
395491011034	active site
395491011035	lytic murein transglycosylase; Region: MltB_2; TIGR02283
395491011036	murein hydrolase B; Provisional; Region: PRK10760; cl17906
395491011037	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491011038	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
395491011039	EamA-like transporter family; Region: EamA; pfam00892
395491011040	EamA-like transporter family; Region: EamA; pfam00892
395491011041	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
395491011042	FAD binding site [chemical binding]; other site
395491011043	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491011044	putative DNA binding site [nucleotide binding]; other site
395491011045	dimerization interface [polypeptide binding]; other site
395491011046	ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983
395491011047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491011048	S-adenosylmethionine binding site [chemical binding]; other site
395491011049	NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234
395491011050	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
395491011051	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491011052	Walker A/P-loop; other site
395491011053	ATP binding site [chemical binding]; other site
395491011054	Q-loop/lid; other site
395491011055	ABC transporter signature motif; other site
395491011056	Walker B; other site
395491011057	D-loop; other site
395491011058	H-loop/switch region; other site
395491011059	ABC transporter; Region: ABC_tran_2; pfam12848
395491011060	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395491011061	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
395491011062	B1 nucleotide binding pocket [chemical binding]; other site
395491011063	B2 nucleotide binding pocket [chemical binding]; other site
395491011064	CAS motifs; other site
395491011065	active site
395491011066	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
395491011067	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395491011068	Protein of unknown function (DUF2920); Region: DUF2920; pfam11144
395491011069	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395491011070	EamA-like transporter family; Region: EamA; pfam00892
395491011071	EamA-like transporter family; Region: EamA; cl17759
395491011072	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
395491011073	CoA-transferase family III; Region: CoA_transf_3; pfam02515
395491011074	thiamine pyrophosphate protein; Validated; Region: PRK08199
395491011075	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395491011076	PYR/PP interface [polypeptide binding]; other site
395491011077	dimer interface [polypeptide binding]; other site
395491011078	TPP binding site [chemical binding]; other site
395491011079	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395491011080	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
395491011081	TPP-binding site [chemical binding]; other site
395491011082	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
395491011083	homotrimer interaction site [polypeptide binding]; other site
395491011084	putative active site [active]
395491011085	Putative phosphatase (DUF442); Region: DUF442; cl17385
395491011086	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
395491011087	active site
395491011088	catalytic residues [active]
395491011089	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395491011090	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491011091	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491011092	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
395491011093	P-loop; other site
395491011094	Magnesium ion binding site [ion binding]; other site
395491011095	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
395491011096	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
395491011097	putative active site [active]
395491011098	metal binding site [ion binding]; metal-binding site
395491011099	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
395491011100	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
395491011101	NAD(P) binding site [chemical binding]; other site
395491011102	catalytic residues [active]
395491011103	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
395491011104	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395491011105	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
395491011106	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
395491011107	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
395491011108	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
395491011109	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
395491011110	putative active site [active]
395491011111	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395491011112	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395491011113	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4132
395491011114	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491011115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491011116	dimer interface [polypeptide binding]; other site
395491011117	conserved gate region; other site
395491011118	putative PBP binding loops; other site
395491011119	ABC-ATPase subunit interface; other site
395491011120	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395491011121	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491011122	Walker A/P-loop; other site
395491011123	ATP binding site [chemical binding]; other site
395491011124	Q-loop/lid; other site
395491011125	ABC transporter signature motif; other site
395491011126	Walker B; other site
395491011127	D-loop; other site
395491011128	H-loop/switch region; other site
395491011129	TOBE domain; Region: TOBE_2; pfam08402
395491011130	NIPSNAP; Region: NIPSNAP; pfam07978
395491011131	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491011132	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491011133	Walker A/P-loop; other site
395491011134	ATP binding site [chemical binding]; other site
395491011135	Q-loop/lid; other site
395491011136	ABC transporter signature motif; other site
395491011137	Walker B; other site
395491011138	D-loop; other site
395491011139	H-loop/switch region; other site
395491011140	TOBE domain; Region: TOBE_2; pfam08402
395491011141	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491011142	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491011143	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491011144	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491011145	dimer interface [polypeptide binding]; other site
395491011146	conserved gate region; other site
395491011147	putative PBP binding loops; other site
395491011148	ABC-ATPase subunit interface; other site
395491011149	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
395491011150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491011151	dimer interface [polypeptide binding]; other site
395491011152	conserved gate region; other site
395491011153	putative PBP binding loops; other site
395491011154	ABC-ATPase subunit interface; other site
395491011155	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491011156	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491011157	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
395491011158	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
395491011159	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491011160	DNA-binding site [nucleotide binding]; DNA binding site
395491011161	UTRA domain; Region: UTRA; pfam07702
395491011162	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
395491011163	putative active site [active]
395491011164	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
395491011165	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
395491011166	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
395491011167	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
395491011168	substrate binding pocket [chemical binding]; other site
395491011169	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
395491011170	B12 binding site [chemical binding]; other site
395491011171	cobalt ligand [ion binding]; other site
395491011172	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
395491011173	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
395491011174	dimerization interface [polypeptide binding]; other site
395491011175	putative active cleft [active]
395491011176	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
395491011177	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
395491011178	hypothetical protein; Provisional; Region: PRK02487
395491011179	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
395491011180	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
395491011181	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491011182	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491011183	dimer interface [polypeptide binding]; other site
395491011184	conserved gate region; other site
395491011185	putative PBP binding loops; other site
395491011186	ABC-ATPase subunit interface; other site
395491011187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491011188	dimer interface [polypeptide binding]; other site
395491011189	conserved gate region; other site
395491011190	putative PBP binding loops; other site
395491011191	ABC-ATPase subunit interface; other site
395491011192	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
395491011193	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395491011194	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395491011195	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491011196	Walker A/P-loop; other site
395491011197	ATP binding site [chemical binding]; other site
395491011198	Q-loop/lid; other site
395491011199	ABC transporter signature motif; other site
395491011200	Walker B; other site
395491011201	D-loop; other site
395491011202	H-loop/switch region; other site
395491011203	TOBE domain; Region: TOBE_2; pfam08402
395491011204	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491011205	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491011206	DNA-binding site [nucleotide binding]; DNA binding site
395491011207	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
395491011208	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
395491011209	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
395491011210	N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791
395491011211	putative active site [active]
395491011212	catalytic site [active]
395491011213	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395491011214	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491011215	DNA binding residues [nucleotide binding]
395491011216	dimerization interface [polypeptide binding]; other site
395491011217	Autoinducer synthetase; Region: Autoind_synth; cl17404
395491011218	Response regulator receiver domain; Region: Response_reg; pfam00072
395491011219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491011220	active site
395491011221	phosphorylation site [posttranslational modification]
395491011222	intermolecular recognition site; other site
395491011223	dimerization interface [polypeptide binding]; other site
395491011224	Uncharacterized conserved protein [Function unknown]; Region: COG2968
395491011225	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
395491011226	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
395491011227	Protein of unknown function (DUF1428); Region: DUF1428; cl02319
395491011228	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664
395491011229	H+ Antiporter protein; Region: 2A0121; TIGR00900
395491011230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491011231	putative substrate translocation pore; other site
395491011232	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491011233	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491011234	ligand binding site [chemical binding]; other site
395491011235	flexible hinge region; other site
395491011236	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491011237	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
395491011238	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
395491011239	B3/4 domain; Region: B3_4; pfam03483
395491011240	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395491011241	EamA-like transporter family; Region: EamA; pfam00892
395491011242	EamA-like transporter family; Region: EamA; pfam00892
395491011243	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
395491011244	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491011245	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491011246	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
395491011247	Phosphotransferase enzyme family; Region: APH; pfam01636
395491011248	active site
395491011249	ATP binding site [chemical binding]; other site
395491011250	antibiotic binding site [chemical binding]; other site
395491011251	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
395491011252	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
395491011253	Uncharacterized conserved protein [Function unknown]; Region: COG4274
395491011254	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
395491011255	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
395491011256	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
395491011257	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
395491011258	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491011259	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
395491011260	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491011261	DNA binding residues [nucleotide binding]
395491011262	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491011263	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
395491011264	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
395491011265	NAD(P) binding site [chemical binding]; other site
395491011266	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
395491011267	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
395491011268	substrate-cofactor binding pocket; other site
395491011269	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491011270	catalytic residue [active]
395491011271	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491011272	S-adenosylmethionine binding site [chemical binding]; other site
395491011273	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
395491011274	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395491011275	ATP binding site [chemical binding]; other site
395491011276	putative Mg++ binding site [ion binding]; other site
395491011277	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491011278	nucleotide binding region [chemical binding]; other site
395491011279	ATP-binding site [chemical binding]; other site
395491011280	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
395491011281	HRDC domain; Region: HRDC; pfam00570
395491011282	DNA primase; Validated; Region: dnaG; PRK05667
395491011283	CHC2 zinc finger; Region: zf-CHC2; cl17510
395491011284	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
395491011285	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
395491011286	active site
395491011287	metal binding site [ion binding]; metal-binding site
395491011288	interdomain interaction site; other site
395491011289	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
395491011290	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442
395491011291	Yqey-like protein; Region: YqeY; pfam09424
395491011292	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
395491011293	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
395491011294	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
395491011295	catalytic site [active]
395491011296	subunit interface [polypeptide binding]; other site
395491011297	multidrug efflux protein; Reviewed; Region: PRK01766
395491011298	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
395491011299	cation binding site [ion binding]; other site
395491011300	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491011301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491011302	putative substrate translocation pore; other site
395491011303	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491011304	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491011305	active site
395491011306	catalytic tetrad [active]
395491011307	Predicted metalloprotease [General function prediction only]; Region: COG2321
395491011308	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
395491011309	Predicted membrane protein [Function unknown]; Region: COG5395
395491011310	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
395491011311	LytTr DNA-binding domain; Region: LytTR; smart00850
395491011312	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
395491011313	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395491011314	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395491011315	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
395491011316	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395491011317	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395491011318	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
395491011319	IMP binding site; other site
395491011320	dimer interface [polypeptide binding]; other site
395491011321	partial ornithine binding site; other site
395491011322	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
395491011323	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
395491011324	Fe-S cluster binding site [ion binding]; other site
395491011325	active site
395491011326	Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277
395491011327	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395491011328	FeS/SAM binding site; other site
395491011329	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
395491011330	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
395491011331	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
395491011332	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491011333	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395491011334	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
395491011335	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
395491011336	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
395491011337	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491011338	dimer interface [polypeptide binding]; other site
395491011339	phosphorylation site [posttranslational modification]
395491011340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491011341	ATP binding site [chemical binding]; other site
395491011342	Mg2+ binding site [ion binding]; other site
395491011343	G-X-G motif; other site
395491011344	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
395491011345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491011346	active site
395491011347	phosphorylation site [posttranslational modification]
395491011348	intermolecular recognition site; other site
395491011349	dimerization interface [polypeptide binding]; other site
395491011350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491011351	Walker A motif; other site
395491011352	ATP binding site [chemical binding]; other site
395491011353	Walker B motif; other site
395491011354	arginine finger; other site
395491011355	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
395491011356	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491011357	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491011358	putative DNA binding site [nucleotide binding]; other site
395491011359	putative Zn2+ binding site [ion binding]; other site
395491011360	AsnC family; Region: AsnC_trans_reg; pfam01037
395491011361	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
395491011362	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395491011363	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395491011364	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491011365	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491011366	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491011367	putative effector binding pocket; other site
395491011368	dimerization interface [polypeptide binding]; other site
395491011369	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491011370	dimerization interface [polypeptide binding]; other site
395491011371	putative DNA binding site [nucleotide binding]; other site
395491011372	putative Zn2+ binding site [ion binding]; other site
395491011373	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
395491011374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491011375	putative substrate translocation pore; other site
395491011376	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
395491011377	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
395491011378	FMN binding site [chemical binding]; other site
395491011379	active site
395491011380	substrate binding site [chemical binding]; other site
395491011381	catalytic residue [active]
395491011382	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
395491011383	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491011384	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491011385	NAD(P) binding site [chemical binding]; other site
395491011386	active site
395491011387	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491011388	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491011389	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491011390	dimerization interface [polypeptide binding]; other site
395491011391	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
395491011392	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
395491011393	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
395491011394	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
395491011395	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
395491011396	Ligand binding site; other site
395491011397	metal-binding site
395491011398	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744
395491011399	putative active site [active]
395491011400	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
395491011401	aspartate aminotransferase; Provisional; Region: PRK05764
395491011402	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491011403	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491011404	homodimer interface [polypeptide binding]; other site
395491011405	catalytic residue [active]
395491011406	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
395491011407	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
395491011408	vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461
395491011409	metal ion-dependent adhesion site (MIDAS); other site
395491011410	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
395491011411	active site
395491011412	catalytic site [active]
395491011413	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
395491011414	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
395491011415	EamA-like transporter family; Region: EamA; pfam00892
395491011416	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395491011417	DNA-binding site [nucleotide binding]; DNA binding site
395491011418	RNA-binding motif; other site
395491011419	BA14K-like protein; Region: BA14K; pfam07886
395491011420	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
395491011421	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491011422	dimerization interface [polypeptide binding]; other site
395491011423	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491011424	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491011425	dimer interface [polypeptide binding]; other site
395491011426	putative CheW interface [polypeptide binding]; other site
395491011427	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491011428	substrate binding pocket [chemical binding]; other site
395491011429	membrane-bound complex binding site; other site
395491011430	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491011431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491011432	dimer interface [polypeptide binding]; other site
395491011433	conserved gate region; other site
395491011434	putative PBP binding loops; other site
395491011435	ABC-ATPase subunit interface; other site
395491011436	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395491011437	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395491011438	Walker A/P-loop; other site
395491011439	ATP binding site [chemical binding]; other site
395491011440	Q-loop/lid; other site
395491011441	ABC transporter signature motif; other site
395491011442	Walker B; other site
395491011443	D-loop; other site
395491011444	H-loop/switch region; other site
395491011445	HAMP domain; Region: HAMP; pfam00672
395491011446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491011447	ATP binding site [chemical binding]; other site
395491011448	Mg2+ binding site [ion binding]; other site
395491011449	G-X-G motif; other site
395491011450	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491011451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491011452	active site
395491011453	phosphorylation site [posttranslational modification]
395491011454	intermolecular recognition site; other site
395491011455	dimerization interface [polypeptide binding]; other site
395491011456	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491011457	DNA binding site [nucleotide binding]
395491011458	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491011459	MarR family; Region: MarR_2; pfam12802
395491011460	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
395491011461	Bacterial SH3 domain; Region: SH3_3; pfam08239
395491011462	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
395491011463	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
395491011464	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
395491011465	dimer interface [polypeptide binding]; other site
395491011466	putative tRNA-binding site [nucleotide binding]; other site
395491011467	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
395491011468	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
395491011469	Uncharacterized conserved protein [Function unknown]; Region: COG5465
395491011470	Membrane fusogenic activity; Region: BMFP; pfam04380
395491011471	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
395491011472	Uncharacterized conserved protein [Function unknown]; Region: COG1565
395491011473	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
395491011474	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
395491011475	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
395491011476	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
395491011477	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
395491011478	active site
395491011479	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
395491011480	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
395491011481	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395491011482	active site
395491011483	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
395491011484	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
395491011485	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491011486	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491011487	metal binding site [ion binding]; metal-binding site
395491011488	active site
395491011489	I-site; other site
395491011490	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491011491	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
395491011492	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
395491011493	5S rRNA interface [nucleotide binding]; other site
395491011494	CTC domain interface [polypeptide binding]; other site
395491011495	L16 interface [polypeptide binding]; other site
395491011496	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491011497	dimerization interface [polypeptide binding]; other site
395491011498	PAS domain S-box; Region: sensory_box; TIGR00229
395491011499	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491011500	putative active site [active]
395491011501	heme pocket [chemical binding]; other site
395491011502	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491011503	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491011504	metal binding site [ion binding]; metal-binding site
395491011505	active site
395491011506	I-site; other site
395491011507	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491011508	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491011509	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491011510	substrate binding pocket [chemical binding]; other site
395491011511	membrane-bound complex binding site; other site
395491011512	hinge residues; other site
395491011513	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
395491011514	putative active site [active]
395491011515	catalytic residue [active]
395491011516	putative acetyltransferase; Provisional; Region: PRK03624
395491011517	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491011518	Coenzyme A binding pocket [chemical binding]; other site
395491011519	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
395491011520	GTP-binding protein YchF; Reviewed; Region: PRK09601
395491011521	YchF GTPase; Region: YchF; cd01900
395491011522	G1 box; other site
395491011523	GTP/Mg2+ binding site [chemical binding]; other site
395491011524	Switch I region; other site
395491011525	G2 box; other site
395491011526	Switch II region; other site
395491011527	G3 box; other site
395491011528	G4 box; other site
395491011529	G5 box; other site
395491011530	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
395491011531	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
395491011532	putative active site [active]
395491011533	putative catalytic site [active]
395491011534	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
395491011535	putative active site [active]
395491011536	putative catalytic site [active]
395491011537	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395491011538	active site
395491011539	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
395491011540	cytochrome b; Provisional; Region: CYTB; MTH00191
395491011541	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
395491011542	Qi binding site; other site
395491011543	intrachain domain interface; other site
395491011544	interchain domain interface [polypeptide binding]; other site
395491011545	heme bH binding site [chemical binding]; other site
395491011546	heme bL binding site [chemical binding]; other site
395491011547	Qo binding site; other site
395491011548	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
395491011549	interchain domain interface [polypeptide binding]; other site
395491011550	intrachain domain interface; other site
395491011551	Qi binding site; other site
395491011552	Qo binding site; other site
395491011553	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
395491011554	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
395491011555	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
395491011556	[2Fe-2S] cluster binding site [ion binding]; other site
395491011557	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
395491011558	putative catalytic site [active]
395491011559	putative metal binding site [ion binding]; other site
395491011560	putative phosphate binding site [ion binding]; other site
395491011561	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395491011562	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491011563	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491011564	Walker A/P-loop; other site
395491011565	ATP binding site [chemical binding]; other site
395491011566	Q-loop/lid; other site
395491011567	ABC transporter signature motif; other site
395491011568	Walker B; other site
395491011569	D-loop; other site
395491011570	H-loop/switch region; other site
395491011571	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
395491011572	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395491011573	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491011574	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
395491011575	Walker A/P-loop; other site
395491011576	ATP binding site [chemical binding]; other site
395491011577	Q-loop/lid; other site
395491011578	ABC transporter signature motif; other site
395491011579	Walker B; other site
395491011580	D-loop; other site
395491011581	H-loop/switch region; other site
395491011582	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
395491011583	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
395491011584	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
395491011585	PhoU domain; Region: PhoU; pfam01895
395491011586	PhoU domain; Region: PhoU; pfam01895
395491011587	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
395491011588	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
395491011589	Predicted small metal-binding protein [Function unknown]; Region: COG5466
395491011590	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
395491011591	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
395491011592	active site
395491011593	NTP binding site [chemical binding]; other site
395491011594	metal binding triad [ion binding]; metal-binding site
395491011595	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
395491011596	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
395491011597	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
395491011598	putative active site [active]
395491011599	putative CoA binding site [chemical binding]; other site
395491011600	nudix motif; other site
395491011601	metal binding site [ion binding]; metal-binding site
395491011602	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
395491011603	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
395491011604	MoxR-like ATPases [General function prediction only]; Region: COG0714
395491011605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491011606	Walker A motif; other site
395491011607	ATP binding site [chemical binding]; other site
395491011608	Walker B motif; other site
395491011609	arginine finger; other site
395491011610	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
395491011611	Protein of unknown function DUF58; Region: DUF58; pfam01882
395491011612	N-terminal double-transmembrane domain; Region: two_anch; TIGR02226
395491011613	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
395491011614	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
395491011615	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
395491011616	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395491011617	Coenzyme A binding pocket [chemical binding]; other site
395491011618	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395491011619	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491011620	Coenzyme A binding pocket [chemical binding]; other site
395491011621	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
395491011622	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
395491011623	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
395491011624	putative dimer interface [polypeptide binding]; other site
395491011625	N-terminal domain interface [polypeptide binding]; other site
395491011626	putative substrate binding pocket (H-site) [chemical binding]; other site
395491011627	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
395491011628	nudix motif; other site
395491011629	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395491011630	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
395491011631	putative active site [active]
395491011632	putative metal binding site [ion binding]; other site
395491011633	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395491011634	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491011635	binding surface
395491011636	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395491011637	TPR motif; other site
395491011638	RNA polymerase sigma factor; Provisional; Region: PRK12547
395491011639	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491011640	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491011641	DNA binding residues [nucleotide binding]
395491011642	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
395491011643	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395491011644	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
395491011645	NAD(P) binding site [chemical binding]; other site
395491011646	Predicted transcriptional regulators [Transcription]; Region: COG1733
395491011647	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395491011648	2-isopropylmalate synthase; Validated; Region: PRK03739
395491011649	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
395491011650	active site
395491011651	catalytic residues [active]
395491011652	metal binding site [ion binding]; metal-binding site
395491011653	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
395491011654	Benzoate membrane transport protein; Region: BenE; pfam03594
395491011655	benzoate transporter; Region: benE; TIGR00843
395491011656	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
395491011657	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
395491011658	oligomer interface [polypeptide binding]; other site
395491011659	active site residues [active]
395491011660	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
395491011661	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
395491011662	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
395491011663	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
395491011664	Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298
395491011665	anthranilate synthase; Provisional; Region: PRK13566
395491011666	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
395491011667	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
395491011668	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
395491011669	glutamine binding [chemical binding]; other site
395491011670	catalytic triad [active]
395491011671	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
395491011672	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395491011673	N-terminal plug; other site
395491011674	ligand-binding site [chemical binding]; other site
395491011675	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
395491011676	Predicted transcriptional regulator [Transcription]; Region: COG3905
395491011677	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
395491011678	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
395491011679	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
395491011680	Potassium binding sites [ion binding]; other site
395491011681	Cesium cation binding sites [ion binding]; other site
395491011682	hypothetical protein; Provisional; Region: PRK05208
395491011683	Predicted periplasmic protein [Function unknown]; Region: COG3904
395491011684	Predicted periplasmic protein [Function unknown]; Region: COG3904
395491011685	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395491011686	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491011687	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491011688	DNA binding residues [nucleotide binding]
395491011689	dimerization interface [polypeptide binding]; other site
395491011690	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
395491011691	PAS fold; Region: PAS_3; pfam08447
395491011692	putative active site [active]
395491011693	heme pocket [chemical binding]; other site
395491011694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345
395491011695	thymidine kinase; Provisional; Region: PRK04296
395491011696	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
395491011697	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
395491011698	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
395491011699	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491011700	dimer interface [polypeptide binding]; other site
395491011701	conserved gate region; other site
395491011702	ABC-ATPase subunit interface; other site
395491011703	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
395491011704	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491011705	Walker A/P-loop; other site
395491011706	ATP binding site [chemical binding]; other site
395491011707	Q-loop/lid; other site
395491011708	ABC transporter signature motif; other site
395491011709	Walker B; other site
395491011710	D-loop; other site
395491011711	H-loop/switch region; other site
395491011712	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
395491011713	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
395491011714	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491011715	dimerization interface [polypeptide binding]; other site
395491011716	putative DNA binding site [nucleotide binding]; other site
395491011717	putative Zn2+ binding site [ion binding]; other site
395491011718	omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360
395491011719	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395491011720	inhibitor-cofactor binding pocket; inhibition site
395491011721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491011722	catalytic residue [active]
395491011723	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
395491011724	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
395491011725	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395491011726	Zn2+ binding site [ion binding]; other site
395491011727	Mg2+ binding site [ion binding]; other site
395491011728	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
395491011729	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
395491011730	dimerization interface [polypeptide binding]; other site
395491011731	ligand binding site [chemical binding]; other site
395491011732	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
395491011733	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491011734	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
395491011735	active site
395491011736	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
395491011737	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
395491011738	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
395491011739	active site
395491011740	catalytic site [active]
395491011741	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
395491011742	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
395491011743	peptide binding site [polypeptide binding]; other site
395491011744	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
395491011745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491011746	dimer interface [polypeptide binding]; other site
395491011747	conserved gate region; other site
395491011748	putative PBP binding loops; other site
395491011749	ABC-ATPase subunit interface; other site
395491011750	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
395491011751	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
395491011752	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491011753	dimer interface [polypeptide binding]; other site
395491011754	conserved gate region; other site
395491011755	putative PBP binding loops; other site
395491011756	ABC-ATPase subunit interface; other site
395491011757	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
395491011758	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491011759	Walker A/P-loop; other site
395491011760	ATP binding site [chemical binding]; other site
395491011761	Q-loop/lid; other site
395491011762	ABC transporter signature motif; other site
395491011763	Walker B; other site
395491011764	D-loop; other site
395491011765	H-loop/switch region; other site
395491011766	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395491011767	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
395491011768	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491011769	Walker A/P-loop; other site
395491011770	ATP binding site [chemical binding]; other site
395491011771	Q-loop/lid; other site
395491011772	ABC transporter signature motif; other site
395491011773	Walker B; other site
395491011774	D-loop; other site
395491011775	H-loop/switch region; other site
395491011776	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395491011777	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
395491011778	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491011779	substrate binding site [chemical binding]; other site
395491011780	ATP binding site [chemical binding]; other site
395491011781	Protein of unknown function (DUF2735); Region: DUF2735; pfam10931
395491011782	glutamine synthetase; Region: PLN02284
395491011783	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
395491011784	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395491011785	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491011786	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
395491011787	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
395491011788	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
395491011789	MarR family; Region: MarR; pfam01047
395491011790	GTP-binding protein Der; Reviewed; Region: PRK00093
395491011791	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
395491011792	G1 box; other site
395491011793	GTP/Mg2+ binding site [chemical binding]; other site
395491011794	Switch I region; other site
395491011795	G2 box; other site
395491011796	Switch II region; other site
395491011797	G3 box; other site
395491011798	G4 box; other site
395491011799	G5 box; other site
395491011800	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
395491011801	G1 box; other site
395491011802	GTP/Mg2+ binding site [chemical binding]; other site
395491011803	Switch I region; other site
395491011804	G2 box; other site
395491011805	G3 box; other site
395491011806	Switch II region; other site
395491011807	G4 box; other site
395491011808	G5 box; other site
395491011809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
395491011810	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
395491011811	NnrU protein; Region: NnrU; pfam07298
395491011812	Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976
395491011813	NodB motif; other site
395491011814	putative active site [active]
395491011815	putative catalytic site [active]
395491011816	microcin B17 transporter; Reviewed; Region: PRK11098
395491011817	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
395491011818	Predicted transcriptional regulators [Transcription]; Region: COG1695
395491011819	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
395491011820	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
395491011821	active site
395491011822	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
395491011823	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
395491011824	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
395491011825	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
395491011826	GIY-YIG motif/motif A; other site
395491011827	putative active site [active]
395491011828	putative metal binding site [ion binding]; other site
395491011829	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
395491011830	putative hydrophobic ligand binding site [chemical binding]; other site
395491011831	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
395491011832	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491011833	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
395491011834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
395491011835	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
395491011836	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395491011837	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
395491011838	conserved cys residue [active]
395491011839	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491011840	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491011841	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
395491011842	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
395491011843	N- and C-terminal domain interface [polypeptide binding]; other site
395491011844	active site
395491011845	MgATP binding site [chemical binding]; other site
395491011846	catalytic site [active]
395491011847	metal binding site [ion binding]; metal-binding site
395491011848	glycerol binding site [chemical binding]; other site
395491011849	homotetramer interface [polypeptide binding]; other site
395491011850	homodimer interface [polypeptide binding]; other site
395491011851	FBP binding site [chemical binding]; other site
395491011852	protein IIAGlc interface [polypeptide binding]; other site
395491011853	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
395491011854	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
395491011855	NAD binding site [chemical binding]; other site
395491011856	homotetramer interface [polypeptide binding]; other site
395491011857	homodimer interface [polypeptide binding]; other site
395491011858	substrate binding site [chemical binding]; other site
395491011859	active site
395491011860	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
395491011861	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395491011862	catalytic loop [active]
395491011863	iron binding site [ion binding]; other site
395491011864	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
395491011865	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
395491011866	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
395491011867	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
395491011868	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395491011869	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
395491011870	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
395491011871	XdhC Rossmann domain; Region: XdhC_C; pfam13478
395491011872	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491011873	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491011874	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
395491011875	dimerization interface [polypeptide binding]; other site
395491011876	substrate binding pocket [chemical binding]; other site
395491011877	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
395491011878	catalytic triad [active]
395491011879	active site nucleophile [active]
395491011880	Predicted membrane protein [Function unknown]; Region: COG3748
395491011881	Protein of unknown function (DUF989); Region: DUF989; pfam06181
395491011882	Cytochrome c; Region: Cytochrom_C; pfam00034
395491011883	guanine deaminase; Provisional; Region: PRK09228
395491011884	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
395491011885	active site
395491011886	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395491011887	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
395491011888	phosphate binding site [ion binding]; other site
395491011889	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
395491011890	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
395491011891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
395491011892	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
395491011893	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
395491011894	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
395491011895	active site
395491011896	metal binding site [ion binding]; metal-binding site
395491011897	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
395491011898	active site
395491011899	homotetramer interface [polypeptide binding]; other site
395491011900	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
395491011901	ureidoglycolate hydrolase; Provisional; Region: PRK03606
395491011902	Protein of unknown function DUF86; Region: DUF86; cl01031
395491011903	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
395491011904	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
395491011905	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
395491011906	active site
395491011907	catalytic site [active]
395491011908	tetramer interface [polypeptide binding]; other site
395491011909	Protein of unknown function (DUF1045); Region: DUF1045; pfam06299
395491011910	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
395491011911	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491011912	Uncharacterized conserved protein [Function unknown]; Region: COG4121
395491011913	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
395491011914	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
395491011915	PAS domain S-box; Region: sensory_box; TIGR00229
395491011916	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491011917	putative active site [active]
395491011918	heme pocket [chemical binding]; other site
395491011919	PAS domain; Region: PAS; smart00091
395491011920	PAS fold; Region: PAS_7; pfam12860
395491011921	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395491011922	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491011923	dimer interface [polypeptide binding]; other site
395491011924	phosphorylation site [posttranslational modification]
395491011925	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491011926	ATP binding site [chemical binding]; other site
395491011927	Mg2+ binding site [ion binding]; other site
395491011928	G-X-G motif; other site
395491011929	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491011930	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491011931	active site
395491011932	phosphorylation site [posttranslational modification]
395491011933	intermolecular recognition site; other site
395491011934	dimerization interface [polypeptide binding]; other site
395491011935	Response regulator receiver domain; Region: Response_reg; pfam00072
395491011936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491011937	active site
395491011938	phosphorylation site [posttranslational modification]
395491011939	intermolecular recognition site; other site
395491011940	dimerization interface [polypeptide binding]; other site
395491011941	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491011942	benzoate transport; Region: 2A0115; TIGR00895
395491011943	putative substrate translocation pore; other site
395491011944	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491011945	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491011946	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
395491011947	inhibitor site; inhibition site
395491011948	active site
395491011949	dimer interface [polypeptide binding]; other site
395491011950	catalytic residue [active]
395491011951	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491011952	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491011953	DNA binding site [nucleotide binding]
395491011954	domain linker motif; other site
395491011955	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395491011956	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
395491011957	helicase 45; Provisional; Region: PTZ00424
395491011958	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
395491011959	ATP binding site [chemical binding]; other site
395491011960	Mg++ binding site [ion binding]; other site
395491011961	motif III; other site
395491011962	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491011963	nucleotide binding region [chemical binding]; other site
395491011964	ATP-binding site [chemical binding]; other site
395491011965	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395491011966	Uncharacterized conserved protein [Function unknown]; Region: COG2308
395491011967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
395491011968	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
395491011969	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395491011970	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395491011971	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395491011972	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
395491011973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491011974	active site
395491011975	phosphorylation site [posttranslational modification]
395491011976	intermolecular recognition site; other site
395491011977	dimerization interface [polypeptide binding]; other site
395491011978	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395491011979	Zn2+ binding site [ion binding]; other site
395491011980	Mg2+ binding site [ion binding]; other site
395491011981	dihydroxy-acid dehydratase; Validated; Region: PRK06131
395491011982	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
395491011983	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395491011984	NAD(P) binding site [chemical binding]; other site
395491011985	catalytic residues [active]
395491011986	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
395491011987	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
395491011988	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491011989	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491011990	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491011991	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491011992	TM-ABC transporter signature motif; other site
395491011993	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491011994	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491011995	Walker A/P-loop; other site
395491011996	ATP binding site [chemical binding]; other site
395491011997	Q-loop/lid; other site
395491011998	ABC transporter signature motif; other site
395491011999	Walker B; other site
395491012000	D-loop; other site
395491012001	H-loop/switch region; other site
395491012002	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491012003	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
395491012004	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
395491012005	putative ligand binding site [chemical binding]; other site
395491012006	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491012007	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491012008	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
395491012009	putative dimerization interface [polypeptide binding]; other site
395491012010	Hint domain; Region: Hint_2; pfam13403
395491012011	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491012012	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491012013	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491012014	MarR family; Region: MarR_2; cl17246
395491012015	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491012016	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395491012017	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
395491012018	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
395491012019	putative ligand binding site [chemical binding]; other site
395491012020	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491012021	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491012022	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491012023	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491012024	TM-ABC transporter signature motif; other site
395491012025	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395491012026	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491012027	Walker A/P-loop; other site
395491012028	ATP binding site [chemical binding]; other site
395491012029	Q-loop/lid; other site
395491012030	ABC transporter signature motif; other site
395491012031	Walker B; other site
395491012032	D-loop; other site
395491012033	H-loop/switch region; other site
395491012034	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
395491012035	Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951
395491012036	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491012037	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491012038	NAD(P) binding site [chemical binding]; other site
395491012039	active site
395491012040	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395491012041	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395491012042	active site
395491012043	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395491012044	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395491012045	active site
395491012046	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
395491012047	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
395491012048	Walker A/P-loop; other site
395491012049	ATP binding site [chemical binding]; other site
395491012050	Q-loop/lid; other site
395491012051	ABC transporter signature motif; other site
395491012052	Walker B; other site
395491012053	D-loop; other site
395491012054	H-loop/switch region; other site
395491012055	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
395491012056	putative carbohydrate binding site [chemical binding]; other site
395491012057	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
395491012058	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395491012059	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
395491012060	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395491012061	active site
395491012062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491012063	S-adenosylmethionine binding site [chemical binding]; other site
395491012064	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
395491012065	putative active site [active]
395491012066	putative metal binding site [ion binding]; other site
395491012067	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395491012068	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395491012069	active site
395491012070	TfuA-like protein; Region: TfuA; pfam07812
395491012071	Uncharacterized conserved protein [Function unknown]; Region: COG1944
395491012072	YcaO-like family; Region: YcaO; pfam02624
395491012073	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491012074	TPR motif; other site
395491012075	binding surface
395491012076	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491012077	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491012078	non-specific DNA binding site [nucleotide binding]; other site
395491012079	salt bridge; other site
395491012080	sequence-specific DNA binding site [nucleotide binding]; other site
395491012081	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395491012082	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491012083	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
395491012084	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
395491012085	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
395491012086	putative ADP-binding pocket [chemical binding]; other site
395491012087	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
395491012088	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
395491012089	trimer interface [polypeptide binding]; other site
395491012090	active site
395491012091	CoA binding site [chemical binding]; other site
395491012092	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
395491012093	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
395491012094	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
395491012095	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
395491012096	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
395491012097	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395491012098	active site
395491012099	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395491012100	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395491012101	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395491012102	active site
395491012103	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395491012104	active site
395491012105	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
395491012106	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101
395491012107	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
395491012108	active site
395491012109	catalytic triad [active]
395491012110	oxyanion hole [active]
395491012111	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
395491012112	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491012113	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491012114	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
395491012115	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491012116	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
395491012117	Walker A/P-loop; other site
395491012118	ATP binding site [chemical binding]; other site
395491012119	Q-loop/lid; other site
395491012120	ABC transporter signature motif; other site
395491012121	Walker B; other site
395491012122	D-loop; other site
395491012123	H-loop/switch region; other site
395491012124	Right handed beta helix region; Region: Beta_helix; pfam13229
395491012125	Chain length determinant protein; Region: Wzz; pfam02706
395491012126	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
395491012127	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491012128	P-loop; other site
395491012129	Magnesium ion binding site [ion binding]; other site
395491012130	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
395491012131	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
395491012132	SLBB domain; Region: SLBB; pfam10531
395491012133	O-Antigen ligase; Region: Wzy_C; pfam04932
395491012134	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
395491012135	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
395491012136	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
395491012137	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
395491012138	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
395491012139	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395491012140	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
395491012141	active site
395491012142	metal binding site [ion binding]; metal-binding site
395491012143	KTSC domain; Region: KTSC; pfam13619
395491012144	Predicted esterase [General function prediction only]; Region: COG0400
395491012145	Serine hydrolase (FSH1); Region: FSH1; pfam03959
395491012146	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
395491012147	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491012148	Zn binding site [ion binding]; other site
395491012149	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
395491012150	Zn binding site [ion binding]; other site
395491012151	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
395491012152	ligand binding site [chemical binding]; other site
395491012153	active site
395491012154	UGI interface [polypeptide binding]; other site
395491012155	catalytic site [active]
395491012156	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
395491012157	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
395491012158	active site
395491012159	substrate binding site [chemical binding]; other site
395491012160	metal binding site [ion binding]; metal-binding site
395491012161	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
395491012162	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
395491012163	Substrate binding site; other site
395491012164	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
395491012165	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
395491012166	putative catalytic site [active]
395491012167	putative metal binding site [ion binding]; other site
395491012168	putative phosphate binding site [ion binding]; other site
395491012169	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491012170	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
395491012171	putative NAD(P) binding site [chemical binding]; other site
395491012172	active site
395491012173	putative substrate binding site [chemical binding]; other site
395491012174	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
395491012175	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491012176	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
395491012177	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
395491012178	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491012179	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491012180	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
395491012181	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
395491012182	Walker A/P-loop; other site
395491012183	ATP binding site [chemical binding]; other site
395491012184	Q-loop/lid; other site
395491012185	ABC transporter signature motif; other site
395491012186	Walker B; other site
395491012187	D-loop; other site
395491012188	H-loop/switch region; other site
395491012189	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
395491012190	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491012191	Walker A/P-loop; other site
395491012192	ATP binding site [chemical binding]; other site
395491012193	Q-loop/lid; other site
395491012194	ABC transporter signature motif; other site
395491012195	Walker B; other site
395491012196	D-loop; other site
395491012197	H-loop/switch region; other site
395491012198	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395491012199	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
395491012200	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395491012201	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395491012202	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
395491012203	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491012204	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491012205	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491012206	Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813
395491012207	conserved cys residue [active]
395491012208	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
395491012209	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491012210	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491012211	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
395491012212	apolar tunnel; other site
395491012213	heme binding site [chemical binding]; other site
395491012214	dimerization interface [polypeptide binding]; other site
395491012215	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
395491012216	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
395491012217	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
395491012218	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
395491012219	Hemin uptake protein hemP; Region: hemP; pfam10636
395491012220	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
395491012221	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
395491012222	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
395491012223	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
395491012224	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
395491012225	putative hemin binding site; other site
395491012226	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
395491012227	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491012228	ABC-ATPase subunit  interface; other site
395491012229	dimer interface [polypeptide binding]; other site
395491012230	putative PBP binding regions; other site
395491012231	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
395491012232	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
395491012233	Walker A/P-loop; other site
395491012234	ATP binding site [chemical binding]; other site
395491012235	Q-loop/lid; other site
395491012236	ABC transporter signature motif; other site
395491012237	Walker B; other site
395491012238	D-loop; other site
395491012239	H-loop/switch region; other site
395491012240	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395491012241	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395491012242	RNA polymerase sigma factor; Provisional; Region: PRK12516
395491012243	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491012244	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491012245	DNA binding residues [nucleotide binding]
395491012246	two-component response regulator; Provisional; Region: PRK09191
395491012247	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
395491012248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491012249	active site
395491012250	phosphorylation site [posttranslational modification]
395491012251	intermolecular recognition site; other site
395491012252	dimerization interface [polypeptide binding]; other site
395491012253	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395491012254	HWE histidine kinase; Region: HWE_HK; pfam07536
395491012255	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
395491012256	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
395491012257	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
395491012258	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
395491012259	homodimer interface [polypeptide binding]; other site
395491012260	active site
395491012261	FMN binding site [chemical binding]; other site
395491012262	substrate binding site [chemical binding]; other site
395491012263	4Fe-4S binding domain; Region: Fer4_6; pfam12837
395491012264	4Fe-4S binding domain; Region: Fer4; pfam00037
395491012265	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
395491012266	RF-1 domain; Region: RF-1; cl17422
395491012267	hypothetical protein; Reviewed; Region: PRK09588
395491012268	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
395491012269	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
395491012270	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
395491012271	conserved cys residue [active]
395491012272	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491012273	Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521
395491012274	active site residue [active]
395491012275	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
395491012276	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395491012277	putative NAD(P) binding site [chemical binding]; other site
395491012278	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491012279	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491012280	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
395491012281	putative effector binding pocket; other site
395491012282	putative dimerization interface [polypeptide binding]; other site
395491012283	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
395491012284	heme binding pocket [chemical binding]; other site
395491012285	heme ligand [chemical binding]; other site
395491012286	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
395491012287	GAF domain; Region: GAF; pfam01590
395491012288	Phytochrome region; Region: PHY; pfam00360
395491012289	HWE histidine kinase; Region: HWE_HK; pfam07536
395491012290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491012291	active site
395491012292	phosphorylation site [posttranslational modification]
395491012293	intermolecular recognition site; other site
395491012294	dimerization interface [polypeptide binding]; other site
395491012295	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
395491012296	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491012297	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
395491012298	allantoate amidohydrolase; Reviewed; Region: PRK12893
395491012299	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
395491012300	active site
395491012301	metal binding site [ion binding]; metal-binding site
395491012302	dimer interface [polypeptide binding]; other site
395491012303	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
395491012304	RNAase interaction site [polypeptide binding]; other site
395491012305	phenylhydantoinase; Validated; Region: PRK08323
395491012306	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
395491012307	tetramer interface [polypeptide binding]; other site
395491012308	active site
395491012309	Cupin domain; Region: Cupin_2; cl17218
395491012310	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395491012311	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395491012312	Walker A/P-loop; other site
395491012313	ATP binding site [chemical binding]; other site
395491012314	Q-loop/lid; other site
395491012315	ABC transporter signature motif; other site
395491012316	Walker B; other site
395491012317	D-loop; other site
395491012318	H-loop/switch region; other site
395491012319	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491012320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491012321	dimer interface [polypeptide binding]; other site
395491012322	conserved gate region; other site
395491012323	putative PBP binding loops; other site
395491012324	ABC-ATPase subunit interface; other site
395491012325	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491012326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491012327	dimer interface [polypeptide binding]; other site
395491012328	conserved gate region; other site
395491012329	putative PBP binding loops; other site
395491012330	ABC-ATPase subunit interface; other site
395491012331	NMT1/THI5 like; Region: NMT1; pfam09084
395491012332	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395491012333	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395491012334	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491012335	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395491012336	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395491012337	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491012338	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491012339	ligand binding site [chemical binding]; other site
395491012340	flexible hinge region; other site
395491012341	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
395491012342	putative switch regulator; other site
395491012343	non-specific DNA interactions [nucleotide binding]; other site
395491012344	DNA binding site [nucleotide binding]
395491012345	sequence specific DNA binding site [nucleotide binding]; other site
395491012346	putative cAMP binding site [chemical binding]; other site
395491012347	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395491012348	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
395491012349	UreF; Region: UreF; pfam01730
395491012350	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
395491012351	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727
395491012352	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
395491012353	dimer interface [polypeptide binding]; other site
395491012354	catalytic residues [active]
395491012355	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491012356	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491012357	metal binding site [ion binding]; metal-binding site
395491012358	active site
395491012359	I-site; other site
395491012360	Protein of unknown function (DUF2459); Region: DUF2459; cl09819
395491012361	urease subunit alpha; Reviewed; Region: ureC; PRK13207
395491012362	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
395491012363	subunit interactions [polypeptide binding]; other site
395491012364	active site
395491012365	flap region; other site
395491012366	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
395491012367	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
395491012368	gamma-beta subunit interface [polypeptide binding]; other site
395491012369	alpha-beta subunit interface [polypeptide binding]; other site
395491012370	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
395491012371	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
395491012372	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
395491012373	alpha-gamma subunit interface [polypeptide binding]; other site
395491012374	beta-gamma subunit interface [polypeptide binding]; other site
395491012375	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
395491012376	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
395491012377	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395491012378	Walker A/P-loop; other site
395491012379	ATP binding site [chemical binding]; other site
395491012380	Q-loop/lid; other site
395491012381	ABC transporter signature motif; other site
395491012382	Walker B; other site
395491012383	D-loop; other site
395491012384	H-loop/switch region; other site
395491012385	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
395491012386	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395491012387	Walker A/P-loop; other site
395491012388	ATP binding site [chemical binding]; other site
395491012389	Q-loop/lid; other site
395491012390	ABC transporter signature motif; other site
395491012391	Walker B; other site
395491012392	D-loop; other site
395491012393	H-loop/switch region; other site
395491012394	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395491012395	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395491012396	TM-ABC transporter signature motif; other site
395491012397	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395491012398	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491012399	TM-ABC transporter signature motif; other site
395491012400	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395491012401	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
395491012402	putative ligand binding site [chemical binding]; other site
395491012403	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
395491012404	active site
395491012405	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
395491012406	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
395491012407	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
395491012408	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491012409	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491012410	dimer interface [polypeptide binding]; other site
395491012411	phosphorylation site [posttranslational modification]
395491012412	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491012413	ATP binding site [chemical binding]; other site
395491012414	Mg2+ binding site [ion binding]; other site
395491012415	G-X-G motif; other site
395491012416	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491012417	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491012418	active site
395491012419	phosphorylation site [posttranslational modification]
395491012420	intermolecular recognition site; other site
395491012421	dimerization interface [polypeptide binding]; other site
395491012422	Response regulator receiver domain; Region: Response_reg; pfam00072
395491012423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491012424	active site
395491012425	phosphorylation site [posttranslational modification]
395491012426	intermolecular recognition site; other site
395491012427	dimerization interface [polypeptide binding]; other site
395491012428	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491012429	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491012430	DNA binding residues [nucleotide binding]
395491012431	dimerization interface [polypeptide binding]; other site
395491012432	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
395491012433	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
395491012434	dimerization interface [polypeptide binding]; other site
395491012435	ligand binding site [chemical binding]; other site
395491012436	NADP binding site [chemical binding]; other site
395491012437	catalytic site [active]
395491012438	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
395491012439	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
395491012440	dimerization interface [polypeptide binding]; other site
395491012441	ligand binding site [chemical binding]; other site
395491012442	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
395491012443	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395491012444	Walker A/P-loop; other site
395491012445	ATP binding site [chemical binding]; other site
395491012446	Q-loop/lid; other site
395491012447	ABC transporter signature motif; other site
395491012448	Walker B; other site
395491012449	D-loop; other site
395491012450	H-loop/switch region; other site
395491012451	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395491012452	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395491012453	Walker A/P-loop; other site
395491012454	ATP binding site [chemical binding]; other site
395491012455	Q-loop/lid; other site
395491012456	ABC transporter signature motif; other site
395491012457	Walker B; other site
395491012458	D-loop; other site
395491012459	H-loop/switch region; other site
395491012460	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
395491012461	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
395491012462	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395491012463	TM-ABC transporter signature motif; other site
395491012464	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491012465	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395491012466	TM-ABC transporter signature motif; other site
395491012467	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
395491012468	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395491012469	active site
395491012470	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395491012471	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
395491012472	Paraquat-inducible protein A; Region: PqiA; pfam04403
395491012473	Predicted acetyltransferase [General function prediction only]; Region: COG2388
395491012474	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491012475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491012476	active site
395491012477	phosphorylation site [posttranslational modification]
395491012478	intermolecular recognition site; other site
395491012479	dimerization interface [polypeptide binding]; other site
395491012480	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491012481	DNA binding site [nucleotide binding]
395491012482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491012483	Response regulator receiver domain; Region: Response_reg; pfam00072
395491012484	active site
395491012485	phosphorylation site [posttranslational modification]
395491012486	intermolecular recognition site; other site
395491012487	dimerization interface [polypeptide binding]; other site
395491012488	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
395491012489	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
395491012490	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
395491012491	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
395491012492	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
395491012493	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
395491012494	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
395491012495	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395491012496	RNA binding surface [nucleotide binding]; other site
395491012497	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
395491012498	active site
395491012499	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
395491012500	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
395491012501	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491012502	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491012503	DNA binding residues [nucleotide binding]
395491012504	cytoskeletal protein RodZ; Provisional; Region: PRK10856
395491012505	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
395491012506	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
395491012507	GDP-binding site [chemical binding]; other site
395491012508	ACT binding site; other site
395491012509	IMP binding site; other site
395491012510	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395491012511	EamA-like transporter family; Region: EamA; pfam00892
395491012512	EamA-like transporter family; Region: EamA; pfam00892
395491012513	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491012514	Coenzyme A binding pocket [chemical binding]; other site
395491012515	PAS fold; Region: PAS_3; pfam08447
395491012516	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491012517	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491012518	metal binding site [ion binding]; metal-binding site
395491012519	active site
395491012520	I-site; other site
395491012521	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491012522	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
395491012523	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
395491012524	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395491012525	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
395491012526	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395491012527	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491012528	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491012529	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
395491012530	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491012531	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491012532	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
395491012533	putative effector binding pocket; other site
395491012534	putative dimerization interface [polypeptide binding]; other site
395491012535	short chain dehydrogenase; Provisional; Region: PRK12937
395491012536	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395491012537	NADP binding site [chemical binding]; other site
395491012538	active site
395491012539	steroid binding site; other site
395491012540	short chain dehydrogenase; Provisional; Region: PRK12937
395491012541	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
395491012542	NADP binding site [chemical binding]; other site
395491012543	homodimer interface [polypeptide binding]; other site
395491012544	active site
395491012545	substrate binding site [chemical binding]; other site
395491012546	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491012547	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491012548	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
395491012549	putative effector binding pocket; other site
395491012550	putative dimerization interface [polypeptide binding]; other site
395491012551	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
395491012552	active site
395491012553	DNA binding site [nucleotide binding]
395491012554	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491012555	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
395491012556	putative substrate translocation pore; other site
395491012557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491012558	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
395491012559	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491012560	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491012561	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491012562	MarR family; Region: MarR; pfam01047
395491012563	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
395491012564	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395491012565	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491012566	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491012567	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395491012568	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395491012569	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
395491012570	active site
395491012571	metal binding site [ion binding]; metal-binding site
395491012572	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
395491012573	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395491012574	active site
395491012575	Predicted transcriptional regulator [Transcription]; Region: COG1959
395491012576	Transcriptional regulator; Region: Rrf2; pfam02082
395491012577	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
395491012578	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491012579	NAD(P) binding site [chemical binding]; other site
395491012580	active site
395491012581	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
395491012582	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
395491012583	DNA interaction; other site
395491012584	Metal-binding active site; metal-binding site
395491012585	AP (apurinic/apyrimidinic) site pocket; other site
395491012586	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491012587	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491012588	DNA binding site [nucleotide binding]
395491012589	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491012590	ligand binding site [chemical binding]; other site
395491012591	dimerization interface [polypeptide binding]; other site
395491012592	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491012593	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
395491012594	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
395491012595	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
395491012596	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
395491012597	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491012598	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491012599	dimer interface [polypeptide binding]; other site
395491012600	conserved gate region; other site
395491012601	putative PBP binding loops; other site
395491012602	ABC-ATPase subunit interface; other site
395491012603	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
395491012604	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491012605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491012606	dimer interface [polypeptide binding]; other site
395491012607	conserved gate region; other site
395491012608	putative PBP binding loops; other site
395491012609	ABC-ATPase subunit interface; other site
395491012610	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395491012611	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491012612	Walker A/P-loop; other site
395491012613	ATP binding site [chemical binding]; other site
395491012614	Q-loop/lid; other site
395491012615	ABC transporter signature motif; other site
395491012616	Walker B; other site
395491012617	D-loop; other site
395491012618	H-loop/switch region; other site
395491012619	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491012620	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491012621	Walker A/P-loop; other site
395491012622	ATP binding site [chemical binding]; other site
395491012623	Q-loop/lid; other site
395491012624	ABC transporter signature motif; other site
395491012625	Walker B; other site
395491012626	D-loop; other site
395491012627	H-loop/switch region; other site
395491012628	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491012629	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
395491012630	tartronate semialdehyde reductase; Provisional; Region: PRK15059
395491012631	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395491012632	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
395491012633	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
395491012634	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
395491012635	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491012636	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491012637	Walker A/P-loop; other site
395491012638	ATP binding site [chemical binding]; other site
395491012639	Q-loop/lid; other site
395491012640	ABC transporter signature motif; other site
395491012641	Walker B; other site
395491012642	D-loop; other site
395491012643	H-loop/switch region; other site
395491012644	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491012645	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491012646	Walker A/P-loop; other site
395491012647	ATP binding site [chemical binding]; other site
395491012648	Q-loop/lid; other site
395491012649	ABC transporter signature motif; other site
395491012650	Walker B; other site
395491012651	D-loop; other site
395491012652	H-loop/switch region; other site
395491012653	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
395491012654	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491012655	dimer interface [polypeptide binding]; other site
395491012656	conserved gate region; other site
395491012657	ABC-ATPase subunit interface; other site
395491012658	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491012659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491012660	putative PBP binding loops; other site
395491012661	dimer interface [polypeptide binding]; other site
395491012662	ABC-ATPase subunit interface; other site
395491012663	Cupin domain; Region: Cupin_2; cl17218
395491012664	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491012665	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491012666	Walker A/P-loop; other site
395491012667	ATP binding site [chemical binding]; other site
395491012668	Q-loop/lid; other site
395491012669	ABC transporter signature motif; other site
395491012670	Walker B; other site
395491012671	D-loop; other site
395491012672	H-loop/switch region; other site
395491012673	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491012674	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491012675	dimer interface [polypeptide binding]; other site
395491012676	conserved gate region; other site
395491012677	putative PBP binding loops; other site
395491012678	ABC-ATPase subunit interface; other site
395491012679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395491012680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491012681	putative PBP binding loops; other site
395491012682	dimer interface [polypeptide binding]; other site
395491012683	ABC-ATPase subunit interface; other site
395491012684	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491012685	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395491012686	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395491012687	non-specific DNA interactions [nucleotide binding]; other site
395491012688	DNA binding site [nucleotide binding]
395491012689	sequence specific DNA binding site [nucleotide binding]; other site
395491012690	putative cAMP binding site [chemical binding]; other site
395491012691	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491012692	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395491012693	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395491012694	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491012695	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491012696	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491012697	dimer interface [polypeptide binding]; other site
395491012698	conserved gate region; other site
395491012699	putative PBP binding loops; other site
395491012700	ABC-ATPase subunit interface; other site
395491012701	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491012702	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491012703	dimer interface [polypeptide binding]; other site
395491012704	conserved gate region; other site
395491012705	putative PBP binding loops; other site
395491012706	ABC-ATPase subunit interface; other site
395491012707	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
395491012708	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
395491012709	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491012710	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
395491012711	substrate binding site [chemical binding]; other site
395491012712	ATP binding site [chemical binding]; other site
395491012713	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491012714	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491012715	Walker A/P-loop; other site
395491012716	ATP binding site [chemical binding]; other site
395491012717	Q-loop/lid; other site
395491012718	ABC transporter signature motif; other site
395491012719	Walker B; other site
395491012720	D-loop; other site
395491012721	H-loop/switch region; other site
395491012722	TOBE domain; Region: TOBE_2; pfam08402
395491012723	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
395491012724	active site
395491012725	catalytic residues [active]
395491012726	colanic acid exporter; Provisional; Region: PRK10459
395491012727	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
395491012728	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
395491012729	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491012730	putative ADP-binding pocket [chemical binding]; other site
395491012731	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395491012732	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491012733	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491012734	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491012735	ligand binding site [chemical binding]; other site
395491012736	flexible hinge region; other site
395491012737	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491012738	putative switch regulator; other site
395491012739	non-specific DNA interactions [nucleotide binding]; other site
395491012740	DNA binding site [nucleotide binding]
395491012741	sequence specific DNA binding site [nucleotide binding]; other site
395491012742	putative cAMP binding site [chemical binding]; other site
395491012743	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395491012744	Chain length determinant protein; Region: Wzz; cl15801
395491012745	AAA domain; Region: AAA_31; pfam13614
395491012746	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
395491012747	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395491012748	active site
395491012749	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395491012750	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
395491012751	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
395491012752	SLBB domain; Region: SLBB; pfam10531
395491012753	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
395491012754	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395491012755	active site
395491012756	active site
395491012757	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
395491012758	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491012759	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491012760	ligand binding site [chemical binding]; other site
395491012761	flexible hinge region; other site
395491012762	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
395491012763	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395491012764	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395491012765	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
395491012766	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
395491012767	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
395491012768	Trp docking motif [polypeptide binding]; other site
395491012769	putative active site [active]
395491012770	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491012771	cyclase homology domain; Region: CHD; cd07302
395491012772	nucleotidyl binding site; other site
395491012773	metal binding site [ion binding]; metal-binding site
395491012774	dimer interface [polypeptide binding]; other site
395491012775	Predicted integral membrane protein [Function unknown]; Region: COG5616
395491012776	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491012777	TPR motif; other site
395491012778	TPR repeat; Region: TPR_11; pfam13414
395491012779	binding surface
395491012780	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491012781	binding surface
395491012782	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395491012783	TPR motif; other site
395491012784	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395491012785	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491012786	cyclase homology domain; Region: CHD; cd07302
395491012787	nucleotidyl binding site; other site
395491012788	metal binding site [ion binding]; metal-binding site
395491012789	dimer interface [polypeptide binding]; other site
395491012790	Predicted integral membrane protein [Function unknown]; Region: COG5616
395491012791	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491012792	binding surface
395491012793	TPR motif; other site
395491012794	TPR repeat; Region: TPR_11; pfam13414
395491012795	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491012796	binding surface
395491012797	TPR motif; other site
395491012798	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395491012799	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
395491012800	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395491012801	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491012802	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491012803	DNA-binding site [nucleotide binding]; DNA binding site
395491012804	FCD domain; Region: FCD; pfam07729
395491012805	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
395491012806	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491012807	ligand binding site [chemical binding]; other site
395491012808	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491012809	extended (e) SDRs; Region: SDR_e; cd08946
395491012810	NAD(P) binding site [chemical binding]; other site
395491012811	active site
395491012812	substrate binding site [chemical binding]; other site
395491012813	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395491012814	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491012815	Walker A/P-loop; other site
395491012816	ATP binding site [chemical binding]; other site
395491012817	Q-loop/lid; other site
395491012818	ABC transporter signature motif; other site
395491012819	Walker B; other site
395491012820	D-loop; other site
395491012821	H-loop/switch region; other site
395491012822	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491012823	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491012824	TM-ABC transporter signature motif; other site
395491012825	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491012826	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491012827	Walker A/P-loop; other site
395491012828	ATP binding site [chemical binding]; other site
395491012829	Q-loop/lid; other site
395491012830	ABC transporter signature motif; other site
395491012831	Walker B; other site
395491012832	D-loop; other site
395491012833	H-loop/switch region; other site
395491012834	TOBE domain; Region: TOBE_2; pfam08402
395491012835	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491012836	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491012837	dimer interface [polypeptide binding]; other site
395491012838	conserved gate region; other site
395491012839	putative PBP binding loops; other site
395491012840	ABC-ATPase subunit interface; other site
395491012841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491012842	dimer interface [polypeptide binding]; other site
395491012843	putative PBP binding loops; other site
395491012844	ABC-ATPase subunit interface; other site
395491012845	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491012846	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395491012847	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
395491012848	classical (c) SDRs; Region: SDR_c; cd05233
395491012849	NAD(P) binding site [chemical binding]; other site
395491012850	active site
395491012851	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491012852	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491012853	DNA-binding site [nucleotide binding]; DNA binding site
395491012854	FCD domain; Region: FCD; pfam07729
395491012855	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
395491012856	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
395491012857	active site pocket [active]
395491012858	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
395491012859	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491012860	classical (c) SDRs; Region: SDR_c; cd05233
395491012861	NAD(P) binding site [chemical binding]; other site
395491012862	active site
395491012863	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
395491012864	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
395491012865	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395491012866	RNA binding surface [nucleotide binding]; other site
395491012867	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
395491012868	active site
395491012869	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395491012870	active site
395491012871	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
395491012872	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
395491012873	TrkA-C domain; Region: TrkA_C; pfam02080
395491012874	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
395491012875	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
395491012876	ATP binding site [chemical binding]; other site
395491012877	active site
395491012878	substrate binding site [chemical binding]; other site
395491012879	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491012880	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491012881	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395491012882	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491012883	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491012884	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
395491012885	Protein export membrane protein; Region: SecD_SecF; cl14618
395491012886	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
395491012887	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491012888	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491012889	DNA binding site [nucleotide binding]
395491012890	domain linker motif; other site
395491012891	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491012892	dimerization interface [polypeptide binding]; other site
395491012893	ligand binding site [chemical binding]; other site
395491012894	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
395491012895	active site
395491012896	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
395491012897	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491012898	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
395491012899	active site
395491012900	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
395491012901	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
395491012902	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
395491012903	metal binding site [ion binding]; metal-binding site
395491012904	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
395491012905	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
395491012906	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
395491012907	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491012908	ABC-ATPase subunit  interface; other site
395491012909	dimer interface [polypeptide binding]; other site
395491012910	putative PBP binding regions; other site
395491012911	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
395491012912	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491012913	ABC-ATPase subunit  interface; other site
395491012914	dimer interface [polypeptide binding]; other site
395491012915	putative PBP binding regions; other site
395491012916	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
395491012917	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
395491012918	metal binding site [ion binding]; metal-binding site
395491012919	putative dimer interface [polypeptide binding]; other site
395491012920	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
395491012921	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
395491012922	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
395491012923	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
395491012924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491012925	active site
395491012926	phosphorylation site [posttranslational modification]
395491012927	intermolecular recognition site; other site
395491012928	dimerization interface [polypeptide binding]; other site
395491012929	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491012930	Walker A motif; other site
395491012931	ATP binding site [chemical binding]; other site
395491012932	Walker B motif; other site
395491012933	arginine finger; other site
395491012934	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395491012935	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
395491012936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491012937	dimer interface [polypeptide binding]; other site
395491012938	phosphorylation site [posttranslational modification]
395491012939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491012940	ATP binding site [chemical binding]; other site
395491012941	Mg2+ binding site [ion binding]; other site
395491012942	G-X-G motif; other site
395491012943	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
395491012944	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
395491012945	Moco binding site; other site
395491012946	metal coordination site [ion binding]; other site
395491012947	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
395491012948	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
395491012949	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395491012950	catalytic core [active]
395491012951	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491012952	metal binding site [ion binding]; metal-binding site
395491012953	active site
395491012954	I-site; other site
395491012955	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491012956	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
395491012957	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
395491012958	propionate/acetate kinase; Provisional; Region: PRK12379
395491012959	acetate kinase; Provisional; Region: PRK07058
395491012960	putative phosphoketolase; Provisional; Region: PRK05261
395491012961	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
395491012962	TPP-binding site; other site
395491012963	XFP C-terminal domain; Region: XFP_C; pfam09363
395491012964	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
395491012965	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
395491012966	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491012967	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
395491012968	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491012969	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
395491012970	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395491012971	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395491012972	TM-ABC transporter signature motif; other site
395491012973	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395491012974	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395491012975	TM-ABC transporter signature motif; other site
395491012976	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395491012977	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395491012978	Walker A/P-loop; other site
395491012979	ATP binding site [chemical binding]; other site
395491012980	Q-loop/lid; other site
395491012981	ABC transporter signature motif; other site
395491012982	Walker B; other site
395491012983	D-loop; other site
395491012984	H-loop/switch region; other site
395491012985	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
395491012986	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395491012987	Walker A/P-loop; other site
395491012988	ATP binding site [chemical binding]; other site
395491012989	Q-loop/lid; other site
395491012990	ABC transporter signature motif; other site
395491012991	Walker B; other site
395491012992	D-loop; other site
395491012993	H-loop/switch region; other site
395491012994	VCBS repeat; Region: VCBS_repeat; TIGR01965
395491012995	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
395491012996	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
395491012997	Ligand Binding Site [chemical binding]; other site
395491012998	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491012999	PAS domain; Region: PAS_9; pfam13426
395491013000	putative active site [active]
395491013001	heme pocket [chemical binding]; other site
395491013002	PAS fold; Region: PAS_4; pfam08448
395491013003	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491013004	putative active site [active]
395491013005	heme pocket [chemical binding]; other site
395491013006	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491013007	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491013008	metal binding site [ion binding]; metal-binding site
395491013009	active site
395491013010	I-site; other site
395491013011	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491013012	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
395491013013	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
395491013014	ligand binding site [chemical binding]; other site
395491013015	NAD binding site [chemical binding]; other site
395491013016	dimerization interface [polypeptide binding]; other site
395491013017	catalytic site [active]
395491013018	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
395491013019	putative L-serine binding site [chemical binding]; other site
395491013020	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
395491013021	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395491013022	catalytic residue [active]
395491013023	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
395491013024	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
395491013025	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
395491013026	active site
395491013027	substrate binding site [chemical binding]; other site
395491013028	metal binding site [ion binding]; metal-binding site
395491013029	FtsH Extracellular; Region: FtsH_ext; pfam06480
395491013030	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
395491013031	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491013032	Walker A motif; other site
395491013033	ATP binding site [chemical binding]; other site
395491013034	Walker B motif; other site
395491013035	arginine finger; other site
395491013036	Peptidase family M41; Region: Peptidase_M41; pfam01434
395491013037	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
395491013038	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
395491013039	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
395491013040	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491013041	TPR motif; other site
395491013042	binding surface
395491013043	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
395491013044	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395491013045	ligand binding site [chemical binding]; other site
395491013046	translocation protein TolB; Provisional; Region: tolB; PRK05137
395491013047	TolB amino-terminal domain; Region: TolB_N; pfam04052
395491013048	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
395491013049	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
395491013050	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
395491013051	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
395491013052	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
395491013053	TolR protein; Region: tolR; TIGR02801
395491013054	TolQ protein; Region: tolQ; TIGR02796
395491013055	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
395491013056	active site
395491013057	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
395491013058	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491013059	NAD binding site [chemical binding]; other site
395491013060	substrate binding site [chemical binding]; other site
395491013061	active site
395491013062	Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537
395491013063	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
395491013064	substrate binding site; other site
395491013065	Manganese binding site; other site
395491013066	dimer interface; other site
395491013067	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491013068	extended (e) SDRs; Region: SDR_e; cd08946
395491013069	NAD(P) binding site [chemical binding]; other site
395491013070	active site
395491013071	substrate binding site [chemical binding]; other site
395491013072	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
395491013073	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
395491013074	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
395491013075	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395491013076	putative active site [active]
395491013077	metal binding site [ion binding]; metal-binding site
395491013078	homodimer binding site [polypeptide binding]; other site
395491013079	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
395491013080	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
395491013081	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
395491013082	hypothetical protein; Validated; Region: PRK00110
395491013083	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
395491013084	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
395491013085	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
395491013086	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491013087	dimerization interface [polypeptide binding]; other site
395491013088	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395491013089	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
395491013090	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491013091	dimer interface [polypeptide binding]; other site
395491013092	putative CheW interface [polypeptide binding]; other site
395491013093	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
395491013094	active site
395491013095	putative DNA-binding cleft [nucleotide binding]; other site
395491013096	dimer interface [polypeptide binding]; other site
395491013097	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
395491013098	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
395491013099	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
395491013100	putative active site [active]
395491013101	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
395491013102	RuvA N terminal domain; Region: RuvA_N; pfam01330
395491013103	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
395491013104	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491013105	Walker A motif; other site
395491013106	ATP binding site [chemical binding]; other site
395491013107	Walker B motif; other site
395491013108	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
395491013109	phosphodiesterase YaeI; Provisional; Region: PRK11340
395491013110	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
395491013111	putative active site [active]
395491013112	putative metal binding site [ion binding]; other site
395491013113	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
395491013114	nudix motif; other site
395491013115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
395491013116	DinB superfamily; Region: DinB_2; pfam12867
395491013117	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
395491013118	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
395491013119	Predicted integral membrane protein [Function unknown]; Region: COG0392
395491013120	Uncharacterized conserved protein [Function unknown]; Region: COG2898
395491013121	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
395491013122	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395491013123	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395491013124	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
395491013125	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395491013126	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
395491013127	hydrophobic ligand binding site; other site
395491013128	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491013129	dimerization interface [polypeptide binding]; other site
395491013130	putative DNA binding site [nucleotide binding]; other site
395491013131	putative Zn2+ binding site [ion binding]; other site
395491013132	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491013133	non-specific DNA binding site [nucleotide binding]; other site
395491013134	salt bridge; other site
395491013135	sequence-specific DNA binding site [nucleotide binding]; other site
395491013136	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491013137	extended (e) SDRs; Region: SDR_e; cd08946
395491013138	NAD(P) binding site [chemical binding]; other site
395491013139	active site
395491013140	substrate binding site [chemical binding]; other site
395491013141	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491013142	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
395491013143	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
395491013144	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
395491013145	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
395491013146	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
395491013147	TPP-binding site [chemical binding]; other site
395491013148	dimer interface [polypeptide binding]; other site
395491013149	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
395491013150	PYR/PP interface [polypeptide binding]; other site
395491013151	dimer interface [polypeptide binding]; other site
395491013152	TPP binding site [chemical binding]; other site
395491013153	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395491013154	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
395491013155	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
395491013156	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
395491013157	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
395491013158	Transporter associated domain; Region: CorC_HlyC; cl08393
395491013159	Phosphoglycerate kinase; Region: PGK; pfam00162
395491013160	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
395491013161	substrate binding site [chemical binding]; other site
395491013162	hinge regions; other site
395491013163	ADP binding site [chemical binding]; other site
395491013164	catalytic site [active]
395491013165	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
395491013166	active site
395491013167	intersubunit interface [polypeptide binding]; other site
395491013168	catalytic residue [active]
395491013169	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
395491013170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491013171	putative MFS family transporter protein; Provisional; Region: PRK03633
395491013172	putative substrate translocation pore; other site
395491013173	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
395491013174	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317
395491013175	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
395491013176	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
395491013177	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491013178	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
395491013179	Walker A/P-loop; other site
395491013180	ATP binding site [chemical binding]; other site
395491013181	Q-loop/lid; other site
395491013182	ABC transporter signature motif; other site
395491013183	Walker B; other site
395491013184	D-loop; other site
395491013185	H-loop/switch region; other site
395491013186	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
395491013187	Uncharacterized conserved protein [Function unknown]; Region: COG3422
395491013188	YCII-related domain; Region: YCII; cl00999
395491013189	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
395491013190	hypothetical protein; Validated; Region: PRK09039
395491013191	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395491013192	ligand binding site [chemical binding]; other site
395491013193	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395491013194	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
395491013195	active site
395491013196	dimerization interface [polypeptide binding]; other site
395491013197	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491013198	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491013199	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395491013200	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491013201	NAD(P) binding site [chemical binding]; other site
395491013202	active site
395491013203	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
395491013204	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491013205	active site
395491013206	phosphorylation site [posttranslational modification]
395491013207	intermolecular recognition site; other site
395491013208	CheB methylesterase; Region: CheB_methylest; pfam01339
395491013209	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
395491013210	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
395491013211	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
395491013212	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
395491013213	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491013214	dimerization interface [polypeptide binding]; other site
395491013215	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491013216	dimer interface [polypeptide binding]; other site
395491013217	putative CheW interface [polypeptide binding]; other site
395491013218	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
395491013219	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491013220	dimerization interface [polypeptide binding]; other site
395491013221	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395491013222	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491013223	dimer interface [polypeptide binding]; other site
395491013224	putative CheW interface [polypeptide binding]; other site
395491013225	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
395491013226	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491013227	dimerization interface [polypeptide binding]; other site
395491013228	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491013229	dimer interface [polypeptide binding]; other site
395491013230	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
395491013231	putative CheW interface [polypeptide binding]; other site
395491013232	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
395491013233	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
395491013234	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
395491013235	putative binding surface; other site
395491013236	active site
395491013237	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
395491013238	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491013239	ATP binding site [chemical binding]; other site
395491013240	Mg2+ binding site [ion binding]; other site
395491013241	G-X-G motif; other site
395491013242	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
395491013243	Response regulator receiver domain; Region: Response_reg; pfam00072
395491013244	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491013245	active site
395491013246	phosphorylation site [posttranslational modification]
395491013247	intermolecular recognition site; other site
395491013248	dimerization interface [polypeptide binding]; other site
395491013249	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
395491013250	methyl-accepting protein IV; Provisional; Region: PRK09793
395491013251	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395491013252	Sel1-like repeats; Region: SEL1; smart00671
395491013253	Sel1-like repeats; Region: SEL1; smart00671
395491013254	Sel1-like repeats; Region: SEL1; smart00671
395491013255	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
395491013256	thiamine phosphate binding site [chemical binding]; other site
395491013257	active site
395491013258	pyrophosphate binding site [ion binding]; other site
395491013259	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395491013260	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491013261	dimerization interface [polypeptide binding]; other site
395491013262	putative DNA binding site [nucleotide binding]; other site
395491013263	putative Zn2+ binding site [ion binding]; other site
395491013264	Uncharacterized small protein [Function unknown]; Region: COG5570
395491013265	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
395491013266	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
395491013267	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
395491013268	ATP-grasp domain; Region: ATP-grasp; pfam02222
395491013269	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
395491013270	TPR repeat; Region: TPR_11; pfam13414
395491013271	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491013272	TPR motif; other site
395491013273	binding surface
395491013274	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491013275	short chain dehydrogenase; Provisional; Region: PRK07041
395491013276	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491013277	NAD(P) binding site [chemical binding]; other site
395491013278	active site
395491013279	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
395491013280	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
395491013281	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
395491013282	hypothetical protein; Provisional; Region: PRK06815
395491013283	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
395491013284	tetramer interface [polypeptide binding]; other site
395491013285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491013286	catalytic residue [active]
395491013287	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395491013288	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491013289	NAD(P) binding site [chemical binding]; other site
395491013290	active site
395491013291	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395491013292	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
395491013293	conserved cys residue [active]
395491013294	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491013295	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
395491013296	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491013297	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491013298	dimerization interface [polypeptide binding]; other site
395491013299	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395491013300	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395491013301	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
395491013302	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
395491013303	pyruvate kinase; Provisional; Region: PRK06247
395491013304	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
395491013305	domain interfaces; other site
395491013306	active site
395491013307	Predicted integral membrane protein [Function unknown]; Region: COG5480
395491013308	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
395491013309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
395491013310	hypothetical protein; Provisional; Region: PRK13694
395491013311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
395491013312	Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951
395491013313	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
395491013314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491013315	active site
395491013316	phosphorylation site [posttranslational modification]
395491013317	intermolecular recognition site; other site
395491013318	dimerization interface [polypeptide binding]; other site
395491013319	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491013320	Walker A motif; other site
395491013321	ATP binding site [chemical binding]; other site
395491013322	Walker B motif; other site
395491013323	arginine finger; other site
395491013324	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395491013325	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
395491013326	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
395491013327	active site
395491013328	Zn binding site [ion binding]; other site
395491013329	aminodeoxychorismate synthase; Provisional; Region: PRK07508
395491013330	chorismate binding enzyme; Region: Chorismate_bind; cl10555
395491013331	hypothetical protein; Provisional; Region: PRK07546
395491013332	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
395491013333	substrate-cofactor binding pocket; other site
395491013334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491013335	catalytic residue [active]
395491013336	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
395491013337	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
395491013338	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
395491013339	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
395491013340	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
395491013341	active site
395491013342	metal binding site [ion binding]; metal-binding site
395491013343	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
395491013344	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
395491013345	ferrochelatase; Reviewed; Region: hemH; PRK00035
395491013346	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
395491013347	C-terminal domain interface [polypeptide binding]; other site
395491013348	active site
395491013349	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
395491013350	active site
395491013351	N-terminal domain interface [polypeptide binding]; other site
395491013352	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
395491013353	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
395491013354	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
395491013355	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
395491013356	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
395491013357	putative active site [active]
395491013358	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
395491013359	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
395491013360	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
395491013361	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
395491013362	active site
395491013363	tetramer interface; other site
395491013364	Transglycosylase SLT domain; Region: SLT_2; pfam13406
395491013365	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395491013366	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395491013367	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491013368	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
395491013369	active site
395491013370	catalytic triad [active]
395491013371	oxyanion hole [active]
395491013372	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
395491013373	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395491013374	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
395491013375	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
395491013376	active site
395491013377	dimer interface [polypeptide binding]; other site
395491013378	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
395491013379	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
395491013380	active site
395491013381	FMN binding site [chemical binding]; other site
395491013382	substrate binding site [chemical binding]; other site
395491013383	3Fe-4S cluster binding site [ion binding]; other site
395491013384	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
395491013385	domain interface; other site
395491013386	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
395491013387	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
395491013388	tetramer interface [polypeptide binding]; other site
395491013389	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491013390	catalytic residue [active]
395491013391	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491013392	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491013393	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491013394	dimerization interface [polypeptide binding]; other site
395491013395	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
395491013396	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
395491013397	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395491013398	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
395491013399	putative dimer interface [polypeptide binding]; other site
395491013400	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
395491013401	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395491013402	TAP-like protein; Region: Abhydrolase_4; pfam08386
395491013403	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395491013404	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
395491013405	active site
395491013406	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
395491013407	Response regulator receiver domain; Region: Response_reg; pfam00072
395491013408	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491013409	active site
395491013410	phosphorylation site [posttranslational modification]
395491013411	intermolecular recognition site; other site
395491013412	dimerization interface [polypeptide binding]; other site
395491013413	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
395491013414	MgtC family; Region: MgtC; pfam02308
395491013415	hypothetical protein; Provisional; Region: PRK14013
395491013416	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
395491013417	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
395491013418	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
395491013419	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395491013420	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395491013421	Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078
395491013422	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
395491013423	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
395491013424	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491013425	cyclase homology domain; Region: CHD; cd07302
395491013426	nucleotidyl binding site; other site
395491013427	metal binding site [ion binding]; metal-binding site
395491013428	dimer interface [polypeptide binding]; other site
395491013429	Predicted integral membrane protein [Function unknown]; Region: COG5616
395491013430	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395491013431	TPR repeat; Region: TPR_11; pfam13414
395491013432	TPR motif; other site
395491013433	binding surface
395491013434	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491013435	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491013436	active site
395491013437	phosphorylation site [posttranslational modification]
395491013438	intermolecular recognition site; other site
395491013439	dimerization interface [polypeptide binding]; other site
395491013440	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491013441	DNA binding site [nucleotide binding]
395491013442	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
395491013443	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491013444	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491013445	dimer interface [polypeptide binding]; other site
395491013446	phosphorylation site [posttranslational modification]
395491013447	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491013448	ATP binding site [chemical binding]; other site
395491013449	Mg2+ binding site [ion binding]; other site
395491013450	G-X-G motif; other site
395491013451	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395491013452	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395491013453	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395491013454	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
395491013455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
395491013456	Uncharacterized conserved protein [Function unknown]; Region: COG2308
395491013457	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
395491013458	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
395491013459	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395491013460	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395491013461	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395491013462	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
395491013463	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
395491013464	metal ion-dependent adhesion site (MIDAS); other site
395491013465	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
395491013466	homodimer interface [polypeptide binding]; other site
395491013467	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
395491013468	active site pocket [active]
395491013469	glycogen branching enzyme; Provisional; Region: PRK05402
395491013470	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
395491013471	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
395491013472	active site
395491013473	catalytic site [active]
395491013474	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
395491013475	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
395491013476	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
395491013477	ligand binding site; other site
395491013478	oligomer interface; other site
395491013479	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
395491013480	dimer interface [polypeptide binding]; other site
395491013481	N-terminal domain interface [polypeptide binding]; other site
395491013482	sulfate 1 binding site; other site
395491013483	glycogen synthase; Provisional; Region: glgA; PRK00654
395491013484	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
395491013485	ADP-binding pocket [chemical binding]; other site
395491013486	homodimer interface [polypeptide binding]; other site
395491013487	phosphoglucomutase; Region: PLN02307
395491013488	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
395491013489	substrate binding site [chemical binding]; other site
395491013490	dimer interface [polypeptide binding]; other site
395491013491	active site
395491013492	metal binding site [ion binding]; metal-binding site
395491013493	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
395491013494	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
395491013495	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
395491013496	active site
395491013497	catalytic site [active]
395491013498	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
395491013499	putative active site [active]
395491013500	putative catalytic site [active]
395491013501	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
395491013502	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491013503	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
395491013504	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
395491013505	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
395491013506	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395491013507	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
395491013508	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
395491013509	hydroxyglutarate oxidase; Provisional; Region: PRK11728
395491013510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
395491013511	FecR protein; Region: FecR; pfam04773
395491013512	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
395491013513	CHASE2 domain; Region: CHASE2; pfam05226
395491013514	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491013515	cyclase homology domain; Region: CHD; cd07302
395491013516	nucleotidyl binding site; other site
395491013517	metal binding site [ion binding]; metal-binding site
395491013518	dimer interface [polypeptide binding]; other site
395491013519	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
395491013520	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491013521	TPR motif; other site
395491013522	TPR repeat; Region: TPR_11; pfam13414
395491013523	binding surface
395491013524	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491013525	binding surface
395491013526	TPR motif; other site
395491013527	TPR repeat; Region: TPR_11; pfam13414
395491013528	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395491013529	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491013530	binding surface
395491013531	TPR motif; other site
395491013532	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395491013533	HWE histidine kinase; Region: HWE_HK; smart00911
395491013534	Protein of unknown function (DUF992); Region: DUF992; pfam06186
395491013535	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
395491013536	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
395491013537	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
395491013538	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
395491013539	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
395491013540	ligand binding site [chemical binding]; other site
395491013541	homodimer interface [polypeptide binding]; other site
395491013542	NAD(P) binding site [chemical binding]; other site
395491013543	trimer interface B [polypeptide binding]; other site
395491013544	trimer interface A [polypeptide binding]; other site
395491013545	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
395491013546	PAS domain; Region: PAS; smart00091
395491013547	PAS fold; Region: PAS_7; pfam12860
395491013548	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491013549	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491013550	metal binding site [ion binding]; metal-binding site
395491013551	active site
395491013552	I-site; other site
395491013553	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491013554	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
395491013555	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
395491013556	DctM-like transporters; Region: DctM; pfam06808
395491013557	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
395491013558	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
395491013559	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
395491013560	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
395491013561	catalytic triad [active]
395491013562	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
395491013563	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
395491013564	putative ligand binding site [chemical binding]; other site
395491013565	NAD binding site [chemical binding]; other site
395491013566	catalytic site [active]
395491013567	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491013568	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491013569	DNA binding site [nucleotide binding]
395491013570	domain linker motif; other site
395491013571	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
395491013572	putative dimerization interface [polypeptide binding]; other site
395491013573	putative ligand binding site [chemical binding]; other site
395491013574	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491013575	MarR family; Region: MarR; pfam01047
395491013576	Creatinine amidohydrolase; Region: Creatininase; pfam02633
395491013577	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395491013578	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
395491013579	P-loop, Walker A motif; other site
395491013580	Base recognition motif; other site
395491013581	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395491013582	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395491013583	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
395491013584	structural tetrad; other site
395491013585	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395491013586	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491013587	Coenzyme A binding pocket [chemical binding]; other site
395491013588	serine acetyltransferase; Provisional; Region: cysE; PRK11132
395491013589	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
395491013590	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
395491013591	trimer interface [polypeptide binding]; other site
395491013592	active site
395491013593	substrate binding site [chemical binding]; other site
395491013594	CoA binding site [chemical binding]; other site
395491013595	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491013596	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491013597	metal binding site [ion binding]; metal-binding site
395491013598	active site
395491013599	I-site; other site
395491013600	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395491013601	Beta-lactamase; Region: Beta-lactamase; pfam00144
395491013602	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491013603	Coenzyme A binding pocket [chemical binding]; other site
395491013604	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
395491013605	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
395491013606	active site
395491013607	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395491013608	dimer interface [polypeptide binding]; other site
395491013609	catalytic residues [active]
395491013610	substrate binding site [chemical binding]; other site
395491013611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491013612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491013613	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491013614	putative effector binding pocket; other site
395491013615	dimerization interface [polypeptide binding]; other site
395491013616	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
395491013617	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
395491013618	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
395491013619	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395491013620	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
395491013621	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
395491013622	putative metal binding site [ion binding]; other site
395491013623	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
395491013624	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
395491013625	active site
395491013626	intersubunit interface [polypeptide binding]; other site
395491013627	catalytic residue [active]
395491013628	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
395491013629	putative active site [active]
395491013630	putative metal binding residues [ion binding]; other site
395491013631	signature motif; other site
395491013632	putative dimer interface [polypeptide binding]; other site
395491013633	putative phosphate binding site [ion binding]; other site
395491013634	CHAD domain; Region: CHAD; pfam05235
395491013635	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
395491013636	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
395491013637	active site residue [active]
395491013638	CHASE4 domain; Region: CHASE4; pfam05228
395491013639	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491013640	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491013641	metal binding site [ion binding]; metal-binding site
395491013642	active site
395491013643	I-site; other site
395491013644	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491013645	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
395491013646	beta-galactosidase; Region: BGL; TIGR03356
395491013647	Predicted membrane protein [Function unknown]; Region: COG2259
395491013648	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491013649	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491013650	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491013651	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491013652	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
395491013653	AP (apurinic/apyrimidinic) site pocket; other site
395491013654	DNA interaction; other site
395491013655	Metal-binding active site; metal-binding site
395491013656	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
395491013657	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491013658	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
395491013659	putative ligand binding site [chemical binding]; other site
395491013660	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491013661	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491013662	TM-ABC transporter signature motif; other site
395491013663	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491013664	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491013665	Walker A/P-loop; other site
395491013666	ATP binding site [chemical binding]; other site
395491013667	Q-loop/lid; other site
395491013668	ABC transporter signature motif; other site
395491013669	Walker B; other site
395491013670	D-loop; other site
395491013671	H-loop/switch region; other site
395491013672	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491013673	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491013674	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491013675	DNA binding site [nucleotide binding]
395491013676	domain linker motif; other site
395491013677	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
395491013678	dimerization interface [polypeptide binding]; other site
395491013679	ligand binding site [chemical binding]; other site
395491013680	xylose isomerase; Provisional; Region: PRK05474
395491013681	xylose isomerase; Region: xylose_isom_A; TIGR02630
395491013682	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
395491013683	N- and C-terminal domain interface [polypeptide binding]; other site
395491013684	D-xylulose kinase; Region: XylB; TIGR01312
395491013685	active site
395491013686	MgATP binding site [chemical binding]; other site
395491013687	catalytic site [active]
395491013688	metal binding site [ion binding]; metal-binding site
395491013689	xylulose binding site [chemical binding]; other site
395491013690	homodimer interface [polypeptide binding]; other site
395491013691	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491013692	DNA binding site [nucleotide binding]
395491013693	domain linker motif; other site
395491013694	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
395491013695	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491013696	putative ligand binding site [chemical binding]; other site
395491013697	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
395491013698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491013699	putative substrate translocation pore; other site
395491013700	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491013701	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
395491013702	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491013703	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491013704	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491013705	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491013706	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
395491013707	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491013708	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491013709	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491013710	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
395491013711	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
395491013712	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
395491013713	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
395491013714	HIGH motif; other site
395491013715	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
395491013716	active site
395491013717	KMSKS motif; other site
395491013718	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
395491013719	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
395491013720	dimer interface [polypeptide binding]; other site
395491013721	putative anticodon binding site; other site
395491013722	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
395491013723	motif 1; other site
395491013724	active site
395491013725	motif 2; other site
395491013726	motif 3; other site
395491013727	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395491013728	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491013729	NAD(P) binding site [chemical binding]; other site
395491013730	active site
395491013731	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
395491013732	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395491013733	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491013734	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491013735	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
395491013736	putative substrate binding pocket [chemical binding]; other site
395491013737	dimerization interface [polypeptide binding]; other site
395491013738	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395491013739	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395491013740	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395491013741	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491013742	Walker A/P-loop; other site
395491013743	ATP binding site [chemical binding]; other site
395491013744	Q-loop/lid; other site
395491013745	ABC transporter signature motif; other site
395491013746	Walker B; other site
395491013747	D-loop; other site
395491013748	H-loop/switch region; other site
395491013749	TOBE domain; Region: TOBE_2; pfam08402
395491013750	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
395491013751	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491013752	dimer interface [polypeptide binding]; other site
395491013753	conserved gate region; other site
395491013754	putative PBP binding loops; other site
395491013755	ABC-ATPase subunit interface; other site
395491013756	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491013757	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491013758	dimer interface [polypeptide binding]; other site
395491013759	conserved gate region; other site
395491013760	putative PBP binding loops; other site
395491013761	ABC-ATPase subunit interface; other site
395491013762	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
395491013763	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
395491013764	tetrameric interface [polypeptide binding]; other site
395491013765	NAD binding site [chemical binding]; other site
395491013766	catalytic residues [active]
395491013767	substrate binding site [chemical binding]; other site
395491013768	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
395491013769	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491013770	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491013771	dimerization interface [polypeptide binding]; other site
395491013772	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491013773	dimer interface [polypeptide binding]; other site
395491013774	phosphorylation site [posttranslational modification]
395491013775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491013776	ATP binding site [chemical binding]; other site
395491013777	Mg2+ binding site [ion binding]; other site
395491013778	G-X-G motif; other site
395491013779	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491013780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491013781	active site
395491013782	phosphorylation site [posttranslational modification]
395491013783	intermolecular recognition site; other site
395491013784	dimerization interface [polypeptide binding]; other site
395491013785	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491013786	DNA binding site [nucleotide binding]
395491013787	Predicted membrane protein [Function unknown]; Region: COG2259
395491013788	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
395491013789	transaldolase-like protein; Provisional; Region: PTZ00411
395491013790	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
395491013791	active site
395491013792	dimer interface [polypeptide binding]; other site
395491013793	catalytic residue [active]
395491013794	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
395491013795	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491013796	DNA binding residues [nucleotide binding]
395491013797	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
395491013798	Helix-turn-helix domain; Region: HTH_18; pfam12833
395491013799	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
395491013800	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
395491013801	DNA binding site [nucleotide binding]
395491013802	active site
395491013803	Integral membrane protein [Function unknown]; Region: COG5488
395491013804	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
395491013805	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
395491013806	minor groove reading motif; other site
395491013807	helix-hairpin-helix signature motif; other site
395491013808	substrate binding pocket [chemical binding]; other site
395491013809	active site
395491013810	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
395491013811	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491013812	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
395491013813	putative dimer interface [polypeptide binding]; other site
395491013814	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491013815	CysZ-like protein; Reviewed; Region: PRK12768
395491013816	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
395491013817	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
395491013818	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
395491013819	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
395491013820	N- and C-terminal domain interface [polypeptide binding]; other site
395491013821	active site
395491013822	MgATP binding site [chemical binding]; other site
395491013823	catalytic site [active]
395491013824	metal binding site [ion binding]; metal-binding site
395491013825	carbohydrate binding site [chemical binding]; other site
395491013826	putative homodimer interface [polypeptide binding]; other site
395491013827	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
395491013828	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491013829	motif II; other site
395491013830	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
395491013831	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
395491013832	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
395491013833	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
395491013834	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491013835	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491013836	Walker A/P-loop; other site
395491013837	ATP binding site [chemical binding]; other site
395491013838	Q-loop/lid; other site
395491013839	ABC transporter signature motif; other site
395491013840	Walker B; other site
395491013841	D-loop; other site
395491013842	H-loop/switch region; other site
395491013843	TOBE domain; Region: TOBE_2; pfam08402
395491013844	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491013845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491013846	dimer interface [polypeptide binding]; other site
395491013847	conserved gate region; other site
395491013848	putative PBP binding loops; other site
395491013849	ABC-ATPase subunit interface; other site
395491013850	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491013851	dimer interface [polypeptide binding]; other site
395491013852	conserved gate region; other site
395491013853	putative PBP binding loops; other site
395491013854	ABC-ATPase subunit interface; other site
395491013855	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491013856	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491013857	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
395491013858	MarR family; Region: MarR_2; pfam12802
395491013859	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
395491013860	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
395491013861	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491013862	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
395491013863	nucleotide binding site [chemical binding]; other site
395491013864	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
395491013865	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
395491013866	active site
395491013867	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395491013868	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395491013869	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491013870	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491013871	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491013872	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491013873	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
395491013874	short chain dehydrogenase; Provisional; Region: PRK07063
395491013875	classical (c) SDRs; Region: SDR_c; cd05233
395491013876	NAD(P) binding site [chemical binding]; other site
395491013877	active site
395491013878	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
395491013879	active site
395491013880	catalytic residues [active]
395491013881	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491013882	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491013883	TM-ABC transporter signature motif; other site
395491013884	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
395491013885	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491013886	Walker A/P-loop; other site
395491013887	ATP binding site [chemical binding]; other site
395491013888	Q-loop/lid; other site
395491013889	ABC transporter signature motif; other site
395491013890	Walker B; other site
395491013891	D-loop; other site
395491013892	H-loop/switch region; other site
395491013893	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491013894	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
395491013895	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
395491013896	ligand binding site [chemical binding]; other site
395491013897	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491013898	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491013899	DNA-binding site [nucleotide binding]; DNA binding site
395491013900	FCD domain; Region: FCD; pfam07729
395491013901	galactonate dehydratase; Provisional; Region: PRK14017
395491013902	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
395491013903	putative active site pocket [active]
395491013904	putative metal binding site [ion binding]; other site
395491013905	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491013906	classical (c) SDRs; Region: SDR_c; cd05233
395491013907	NAD(P) binding site [chemical binding]; other site
395491013908	active site
395491013909	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491013910	cyclase homology domain; Region: CHD; cd07302
395491013911	nucleotidyl binding site; other site
395491013912	metal binding site [ion binding]; metal-binding site
395491013913	dimer interface [polypeptide binding]; other site
395491013914	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491013915	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491013916	DNA binding site [nucleotide binding]
395491013917	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395491013918	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
395491013919	short chain dehydrogenase; Provisional; Region: PRK06198
395491013920	classical (c) SDRs; Region: SDR_c; cd05233
395491013921	NAD(P) binding site [chemical binding]; other site
395491013922	active site
395491013923	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
395491013924	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
395491013925	conserved cys residue [active]
395491013926	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491013927	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491013928	Walker A/P-loop; other site
395491013929	ATP binding site [chemical binding]; other site
395491013930	Q-loop/lid; other site
395491013931	ABC transporter signature motif; other site
395491013932	Walker B; other site
395491013933	D-loop; other site
395491013934	H-loop/switch region; other site
395491013935	TOBE domain; Region: TOBE_2; pfam08402
395491013936	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491013937	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491013938	dimer interface [polypeptide binding]; other site
395491013939	conserved gate region; other site
395491013940	putative PBP binding loops; other site
395491013941	ABC-ATPase subunit interface; other site
395491013942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491013943	dimer interface [polypeptide binding]; other site
395491013944	conserved gate region; other site
395491013945	putative PBP binding loops; other site
395491013946	ABC-ATPase subunit interface; other site
395491013947	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491013948	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395491013949	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491013950	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491013951	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491013952	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491013953	DNA binding site [nucleotide binding]
395491013954	domain linker motif; other site
395491013955	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395491013956	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
395491013957	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
395491013958	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
395491013959	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
395491013960	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491013961	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491013962	Walker A/P-loop; other site
395491013963	ATP binding site [chemical binding]; other site
395491013964	Q-loop/lid; other site
395491013965	ABC transporter signature motif; other site
395491013966	Walker B; other site
395491013967	D-loop; other site
395491013968	H-loop/switch region; other site
395491013969	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491013970	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491013971	dimer interface [polypeptide binding]; other site
395491013972	conserved gate region; other site
395491013973	putative PBP binding loops; other site
395491013974	ABC-ATPase subunit interface; other site
395491013975	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491013976	dimer interface [polypeptide binding]; other site
395491013977	putative PBP binding loops; other site
395491013978	ABC-ATPase subunit interface; other site
395491013979	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491013980	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491013981	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491013982	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491013983	DNA binding site [nucleotide binding]
395491013984	domain linker motif; other site
395491013985	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
395491013986	ligand binding site [chemical binding]; other site
395491013987	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
395491013988	Ligand Binding Site [chemical binding]; other site
395491013989	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
395491013990	active site
395491013991	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
395491013992	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
395491013993	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491013994	cyclase homology domain; Region: CHD; cd07302
395491013995	nucleotidyl binding site; other site
395491013996	metal binding site [ion binding]; metal-binding site
395491013997	dimer interface [polypeptide binding]; other site
395491013998	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
395491013999	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
395491014000	dimer interface [polypeptide binding]; other site
395491014001	putative radical transfer pathway; other site
395491014002	diiron center [ion binding]; other site
395491014003	tyrosyl radical; other site
395491014004	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
395491014005	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
395491014006	Class I ribonucleotide reductase; Region: RNR_I; cd01679
395491014007	active site
395491014008	dimer interface [polypeptide binding]; other site
395491014009	catalytic residues [active]
395491014010	effector binding site; other site
395491014011	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
395491014012	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
395491014013	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
395491014014	catalytic residues [active]
395491014015	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
395491014016	metal-binding site [ion binding]
395491014017	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
395491014018	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395491014019	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
395491014020	DNA binding residues [nucleotide binding]
395491014021	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
395491014022	dimer interface [polypeptide binding]; other site
395491014023	putative metal binding site [ion binding]; other site
395491014024	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
395491014025	methionine sulfoxide reductase B; Provisional; Region: PRK00222
395491014026	SelR domain; Region: SelR; pfam01641
395491014027	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
395491014028	GAF domain; Region: GAF; cl17456
395491014029	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395491014030	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
395491014031	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395491014032	NAD(P) binding site [chemical binding]; other site
395491014033	catalytic residues [active]
395491014034	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564
395491014035	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
395491014036	intracellular protease, PfpI family; Region: PfpI; TIGR01382
395491014037	conserved cys residue [active]
395491014038	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
395491014039	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
395491014040	classical (c) SDRs; Region: SDR_c; cd05233
395491014041	NAD(P) binding site [chemical binding]; other site
395491014042	active site
395491014043	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
395491014044	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
395491014045	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395491014046	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491014047	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
395491014048	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491014049	dimerization interface [polypeptide binding]; other site
395491014050	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395491014051	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491014052	dimer interface [polypeptide binding]; other site
395491014053	putative CheW interface [polypeptide binding]; other site
395491014054	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
395491014055	Peptidase family M23; Region: Peptidase_M23; pfam01551
395491014056	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
395491014057	Clp amino terminal domain; Region: Clp_N; pfam02861
395491014058	Clp amino terminal domain; Region: Clp_N; pfam02861
395491014059	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491014060	Walker A motif; other site
395491014061	ATP binding site [chemical binding]; other site
395491014062	Walker B motif; other site
395491014063	arginine finger; other site
395491014064	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491014065	Walker A motif; other site
395491014066	ATP binding site [chemical binding]; other site
395491014067	Walker B motif; other site
395491014068	arginine finger; other site
395491014069	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
395491014070	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
395491014071	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
395491014072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491014073	S-adenosylmethionine binding site [chemical binding]; other site
395491014074	peptide chain release factor 1; Validated; Region: prfA; PRK00591
395491014075	This domain is found in peptide chain release factors; Region: PCRF; smart00937
395491014076	RF-1 domain; Region: RF-1; pfam00472
395491014077	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
395491014078	GAF domain; Region: GAF; pfam01590
395491014079	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
395491014080	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
395491014081	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
395491014082	aspartate kinase; Reviewed; Region: PRK06635
395491014083	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
395491014084	putative nucleotide binding site [chemical binding]; other site
395491014085	putative catalytic residues [active]
395491014086	putative Mg ion binding site [ion binding]; other site
395491014087	putative aspartate binding site [chemical binding]; other site
395491014088	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
395491014089	putative allosteric regulatory site; other site
395491014090	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
395491014091	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
395491014092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491014093	S-adenosylmethionine binding site [chemical binding]; other site
395491014094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319
395491014095	Predicted amidohydrolase [General function prediction only]; Region: COG0388
395491014096	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
395491014097	putative active site [active]
395491014098	catalytic triad [active]
395491014099	dimer interface [polypeptide binding]; other site
395491014100	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
395491014101	GSH binding site [chemical binding]; other site
395491014102	catalytic residues [active]
395491014103	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
395491014104	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395491014105	active site
395491014106	Methyltransferase domain; Region: Methyltransf_11; pfam08241
395491014107	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
395491014108	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
395491014109	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
395491014110	active site
395491014111	8-oxo-dGMP binding site [chemical binding]; other site
395491014112	nudix motif; other site
395491014113	metal binding site [ion binding]; metal-binding site
395491014114	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395491014115	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
395491014116	heterotetramer interface [polypeptide binding]; other site
395491014117	active site pocket [active]
395491014118	cleavage site
395491014119	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
395491014120	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
395491014121	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
395491014122	DEAD/DEAH box helicase; Region: DEAD; pfam00270
395491014123	ATP binding site [chemical binding]; other site
395491014124	putative Mg++ binding site [ion binding]; other site
395491014125	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
395491014126	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
395491014127	nucleotide binding region [chemical binding]; other site
395491014128	SEC-C motif; Region: SEC-C; pfam02810
395491014129	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
395491014130	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
395491014131	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
395491014132	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
395491014133	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971
395491014134	active site
395491014135	acyl-activating enzyme (AAE) consensus motif; other site
395491014136	putative CoA binding site [chemical binding]; other site
395491014137	AMP binding site [chemical binding]; other site
395491014138	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491014139	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491014140	active site
395491014141	catalytic tetrad [active]
395491014142	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491014143	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491014144	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491014145	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491014146	putative substrate translocation pore; other site
395491014147	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
395491014148	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491014149	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491014150	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491014151	dimerization interface [polypeptide binding]; other site
395491014152	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
395491014153	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
395491014154	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491014155	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491014156	ligand binding site [chemical binding]; other site
395491014157	flexible hinge region; other site
395491014158	Predicted membrane protein [Function unknown]; Region: COG1238
395491014159	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
395491014160	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
395491014161	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
395491014162	active site
395491014163	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
395491014164	endonuclease III; Region: ENDO3c; smart00478
395491014165	minor groove reading motif; other site
395491014166	helix-hairpin-helix signature motif; other site
395491014167	substrate binding pocket [chemical binding]; other site
395491014168	active site
395491014169	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
395491014170	active site
395491014171	HIGH motif; other site
395491014172	nucleotide binding site [chemical binding]; other site
395491014173	active site
395491014174	KMSKS motif; other site
395491014175	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
395491014176	short chain dehydrogenase; Provisional; Region: PRK05993
395491014177	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395491014178	NADP binding site [chemical binding]; other site
395491014179	active site
395491014180	steroid binding site; other site
395491014181	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
395491014182	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
395491014183	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
395491014184	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
395491014185	Ligand binding site [chemical binding]; other site
395491014186	Electron transfer flavoprotein domain; Region: ETF; pfam01012
395491014187	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
395491014188	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
395491014189	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
395491014190	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
395491014191	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
395491014192	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395491014193	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
395491014194	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395491014195	catalytic residues [active]
395491014196	argininosuccinate lyase; Provisional; Region: PRK00855
395491014197	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
395491014198	active sites [active]
395491014199	tetramer interface [polypeptide binding]; other site
395491014200	diaminopimelate decarboxylase; Region: lysA; TIGR01048
395491014201	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
395491014202	active site
395491014203	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395491014204	substrate binding site [chemical binding]; other site
395491014205	catalytic residues [active]
395491014206	dimer interface [polypeptide binding]; other site
395491014207	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
395491014208	Response regulator receiver domain; Region: Response_reg; pfam00072
395491014209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491014210	active site
395491014211	phosphorylation site [posttranslational modification]
395491014212	intermolecular recognition site; other site
395491014213	dimerization interface [polypeptide binding]; other site
395491014214	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395491014215	active site
395491014216	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
395491014217	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
395491014218	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395491014219	Walker A/P-loop; other site
395491014220	ATP binding site [chemical binding]; other site
395491014221	Q-loop/lid; other site
395491014222	ABC transporter signature motif; other site
395491014223	Walker B; other site
395491014224	D-loop; other site
395491014225	H-loop/switch region; other site
395491014226	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
395491014227	Uncharacterized conserved protein [Function unknown]; Region: COG1434
395491014228	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
395491014229	putative active site [active]
395491014230	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395491014231	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395491014232	putative acyl-acceptor binding pocket; other site
395491014233	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
395491014234	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
395491014235	putative active site pocket [active]
395491014236	dimerization interface [polypeptide binding]; other site
395491014237	putative catalytic residue [active]
395491014238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
395491014239	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
395491014240	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491014241	Coenzyme A binding pocket [chemical binding]; other site
395491014242	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
395491014243	prephenate dehydrogenase; Validated; Region: PRK08507
395491014244	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
395491014245	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491014246	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491014247	homodimer interface [polypeptide binding]; other site
395491014248	catalytic residue [active]
395491014249	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395491014250	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491014251	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
395491014252	Uncharacterized conserved protein [Function unknown]; Region: COG3542
395491014253	aromatic amino acid exporter; Provisional; Region: PRK11689
395491014254	EamA-like transporter family; Region: EamA; pfam00892
395491014255	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
395491014256	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
395491014257	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
395491014258	hypothetical protein; Validated; Region: PRK06217
395491014259	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
395491014260	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
395491014261	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
395491014262	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
395491014263	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
395491014264	metal ion-dependent adhesion site (MIDAS); other site
395491014265	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
395491014266	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
395491014267	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395491014268	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
395491014269	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395491014270	HSP70 interaction site [polypeptide binding]; other site
395491014271	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
395491014272	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
395491014273	Domain of unknown function DUF21; Region: DUF21; pfam01595
395491014274	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
395491014275	Transporter associated domain; Region: CorC_HlyC; smart01091
395491014276	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
395491014277	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
395491014278	active site
395491014279	dimer interface [polypeptide binding]; other site
395491014280	metal binding site [ion binding]; metal-binding site
395491014281	shikimate kinase; Provisional; Region: PRK13946
395491014282	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
395491014283	ADP binding site [chemical binding]; other site
395491014284	magnesium binding site [ion binding]; other site
395491014285	putative shikimate binding site; other site
395491014286	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
395491014287	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395491014288	active site
395491014289	DNA binding site [nucleotide binding]
395491014290	Int/Topo IB signature motif; other site
395491014291	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
395491014292	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
395491014293	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
395491014294	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
395491014295	CPxP  motif; other site
395491014296	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395491014297	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395491014298	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395491014299	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
395491014300	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
395491014301	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
395491014302	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
395491014303	metal binding site [ion binding]; metal-binding site
395491014304	putative dimer interface [polypeptide binding]; other site
395491014305	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395491014306	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
395491014307	BON domain; Region: BON; pfam04972
395491014308	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
395491014309	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
395491014310	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
395491014311	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
395491014312	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
395491014313	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491014314	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491014315	Walker A/P-loop; other site
395491014316	ATP binding site [chemical binding]; other site
395491014317	Q-loop/lid; other site
395491014318	ABC transporter signature motif; other site
395491014319	Walker B; other site
395491014320	D-loop; other site
395491014321	H-loop/switch region; other site
395491014322	TOBE domain; Region: TOBE_2; pfam08402
395491014323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
395491014324	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
395491014325	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491014326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014327	dimer interface [polypeptide binding]; other site
395491014328	conserved gate region; other site
395491014329	putative PBP binding loops; other site
395491014330	ABC-ATPase subunit interface; other site
395491014331	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
395491014332	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014333	putative PBP binding loops; other site
395491014334	ABC-ATPase subunit interface; other site
395491014335	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491014336	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491014337	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491014338	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491014339	DNA binding site [nucleotide binding]
395491014340	domain linker motif; other site
395491014341	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491014342	dimerization interface [polypeptide binding]; other site
395491014343	ligand binding site [chemical binding]; other site
395491014344	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
395491014345	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
395491014346	substrate-cofactor binding pocket; other site
395491014347	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491014348	catalytic residue [active]
395491014349	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
395491014350	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395491014351	Surface antigen; Region: Bac_surface_Ag; pfam01103
395491014352	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
395491014353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
395491014354	Family of unknown function (DUF490); Region: DUF490; pfam04357
395491014355	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491014356	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
395491014357	AsnC family; Region: AsnC_trans_reg; pfam01037
395491014358	Arginase family; Region: Arginase; cd09989
395491014359	active site
395491014360	Mn binding site [ion binding]; other site
395491014361	oligomer interface [polypeptide binding]; other site
395491014362	ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854
395491014363	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395491014364	inhibitor-cofactor binding pocket; inhibition site
395491014365	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491014366	catalytic residue [active]
395491014367	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
395491014368	putative CheA interaction surface; other site
395491014369	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491014370	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491014371	putative active site [active]
395491014372	heme pocket [chemical binding]; other site
395491014373	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491014374	putative active site [active]
395491014375	heme pocket [chemical binding]; other site
395491014376	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491014377	dimer interface [polypeptide binding]; other site
395491014378	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
395491014379	putative CheW interface [polypeptide binding]; other site
395491014380	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491014381	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
395491014382	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
395491014383	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
395491014384	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395491014385	catalytic loop [active]
395491014386	iron binding site [ion binding]; other site
395491014387	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
395491014388	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
395491014389	[4Fe-4S] binding site [ion binding]; other site
395491014390	molybdopterin cofactor binding site; other site
395491014391	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
395491014392	molybdopterin cofactor binding site; other site
395491014393	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
395491014394	putative dimer interface [polypeptide binding]; other site
395491014395	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
395491014396	SLBB domain; Region: SLBB; pfam10531
395491014397	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
395491014398	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
395491014399	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
395491014400	putative dimer interface [polypeptide binding]; other site
395491014401	[2Fe-2S] cluster binding site [ion binding]; other site
395491014402	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491014403	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491014404	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395491014405	dimerization interface [polypeptide binding]; other site
395491014406	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491014407	dimerization interface [polypeptide binding]; other site
395491014408	putative DNA binding site [nucleotide binding]; other site
395491014409	putative Zn2+ binding site [ion binding]; other site
395491014410	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
395491014411	classical (c) SDRs; Region: SDR_c; cd05233
395491014412	NAD(P) binding site [chemical binding]; other site
395491014413	active site
395491014414	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
395491014415	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
395491014416	DNA binding residues [nucleotide binding]
395491014417	dimer interface [polypeptide binding]; other site
395491014418	[2Fe-2S] cluster binding site [ion binding]; other site
395491014419	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491014420	Predicted flavoprotein [General function prediction only]; Region: COG0431
395491014421	YKOF-related Family; Region: Ykof; pfam07615
395491014422	YKOF-related Family; Region: Ykof; pfam07615
395491014423	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491014424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014425	putative PBP binding loops; other site
395491014426	ABC-ATPase subunit interface; other site
395491014427	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395491014428	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395491014429	Walker A/P-loop; other site
395491014430	ATP binding site [chemical binding]; other site
395491014431	Q-loop/lid; other site
395491014432	ABC transporter signature motif; other site
395491014433	Walker B; other site
395491014434	D-loop; other site
395491014435	H-loop/switch region; other site
395491014436	NMT1/THI5 like; Region: NMT1; pfam09084
395491014437	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491014438	substrate binding pocket [chemical binding]; other site
395491014439	membrane-bound complex binding site; other site
395491014440	hinge residues; other site
395491014441	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395491014442	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395491014443	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
395491014444	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
395491014445	gamma subunit interface [polypeptide binding]; other site
395491014446	epsilon subunit interface [polypeptide binding]; other site
395491014447	LBP interface [polypeptide binding]; other site
395491014448	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
395491014449	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
395491014450	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
395491014451	alpha subunit interaction interface [polypeptide binding]; other site
395491014452	Walker A motif; other site
395491014453	ATP binding site [chemical binding]; other site
395491014454	Walker B motif; other site
395491014455	inhibitor binding site; inhibition site
395491014456	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
395491014457	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
395491014458	core domain interface [polypeptide binding]; other site
395491014459	delta subunit interface [polypeptide binding]; other site
395491014460	epsilon subunit interface [polypeptide binding]; other site
395491014461	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
395491014462	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
395491014463	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
395491014464	beta subunit interaction interface [polypeptide binding]; other site
395491014465	Walker A motif; other site
395491014466	ATP binding site [chemical binding]; other site
395491014467	Walker B motif; other site
395491014468	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
395491014469	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
395491014470	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
395491014471	primosome assembly protein PriA; Validated; Region: PRK05580
395491014472	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395491014473	ATP binding site [chemical binding]; other site
395491014474	putative Mg++ binding site [ion binding]; other site
395491014475	helicase superfamily c-terminal domain; Region: HELICc; smart00490
395491014476	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491014477	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491014478	Walker A/P-loop; other site
395491014479	ATP binding site [chemical binding]; other site
395491014480	Q-loop/lid; other site
395491014481	ABC transporter signature motif; other site
395491014482	Walker B; other site
395491014483	D-loop; other site
395491014484	H-loop/switch region; other site
395491014485	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491014486	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
395491014487	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491014488	Walker A/P-loop; other site
395491014489	ATP binding site [chemical binding]; other site
395491014490	Q-loop/lid; other site
395491014491	ABC transporter signature motif; other site
395491014492	Walker B; other site
395491014493	D-loop; other site
395491014494	H-loop/switch region; other site
395491014495	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395491014496	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491014497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014498	dimer interface [polypeptide binding]; other site
395491014499	conserved gate region; other site
395491014500	putative PBP binding loops; other site
395491014501	ABC-ATPase subunit interface; other site
395491014502	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491014503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014504	dimer interface [polypeptide binding]; other site
395491014505	conserved gate region; other site
395491014506	putative PBP binding loops; other site
395491014507	ABC-ATPase subunit interface; other site
395491014508	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491014509	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
395491014510	substrate binding site [chemical binding]; other site
395491014511	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
395491014512	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491014513	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
395491014514	DNA-binding site [nucleotide binding]; DNA binding site
395491014515	FCD domain; Region: FCD; pfam07729
395491014516	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491014517	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491014518	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491014519	dihydroxy-acid dehydratase; Validated; Region: PRK06131
395491014520	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
395491014521	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491014522	active site
395491014523	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491014524	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
395491014525	inhibitor site; inhibition site
395491014526	active site
395491014527	dimer interface [polypeptide binding]; other site
395491014528	catalytic residue [active]
395491014529	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491014530	Coenzyme A binding pocket [chemical binding]; other site
395491014531	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
395491014532	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395491014533	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
395491014534	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395491014535	active site
395491014536	DNA binding site [nucleotide binding]
395491014537	Int/Topo IB signature motif; other site
395491014538	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
395491014539	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
395491014540	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
395491014541	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
395491014542	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395491014543	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395491014544	classical (c) SDRs; Region: SDR_c; cd05233
395491014545	NAD(P) binding site [chemical binding]; other site
395491014546	active site
395491014547	Protein of unknown function (DUF4241); Region: DUF4241; pfam14025
395491014548	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
395491014549	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395491014550	E3 interaction surface; other site
395491014551	lipoyl attachment site [posttranslational modification]; other site
395491014552	e3 binding domain; Region: E3_binding; pfam02817
395491014553	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
395491014554	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
395491014555	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
395491014556	TPP-binding site [chemical binding]; other site
395491014557	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
395491014558	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
395491014559	CoA binding domain; Region: CoA_binding; smart00881
395491014560	CoA-ligase; Region: Ligase_CoA; pfam00549
395491014561	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
395491014562	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
395491014563	CoA-ligase; Region: Ligase_CoA; pfam00549
395491014564	malate dehydrogenase; Reviewed; Region: PRK06223
395491014565	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
395491014566	NAD(P) binding site [chemical binding]; other site
395491014567	dimer interface [polypeptide binding]; other site
395491014568	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395491014569	substrate binding site [chemical binding]; other site
395491014570	Predicted ATPase [General function prediction only]; Region: COG1485
395491014571	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491014572	Walker A/P-loop; other site
395491014573	ATP binding site [chemical binding]; other site
395491014574	ABC transporter signature motif; other site
395491014575	Walker B; other site
395491014576	D-loop; other site
395491014577	H-loop/switch region; other site
395491014578	Protease inhibitor Inh; Region: Inh; pfam02974
395491014579	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
395491014580	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
395491014581	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
395491014582	L-aspartate oxidase; Provisional; Region: PRK06175
395491014583	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
395491014584	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
395491014585	putative SdhC subunit interface [polypeptide binding]; other site
395491014586	putative proximal heme binding site [chemical binding]; other site
395491014587	putative Iron-sulfur protein interface [polypeptide binding]; other site
395491014588	putative proximal quinone binding site; other site
395491014589	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
395491014590	Iron-sulfur protein interface; other site
395491014591	proximal quinone binding site [chemical binding]; other site
395491014592	SdhD (CybS) interface [polypeptide binding]; other site
395491014593	proximal heme binding site [chemical binding]; other site
395491014594	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
395491014595	homotrimer interaction site [polypeptide binding]; other site
395491014596	putative active site [active]
395491014597	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491014598	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491014599	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491014600	dimerization interface [polypeptide binding]; other site
395491014601	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395491014602	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491014603	Walker A/P-loop; other site
395491014604	ATP binding site [chemical binding]; other site
395491014605	Q-loop/lid; other site
395491014606	ABC transporter signature motif; other site
395491014607	Walker B; other site
395491014608	D-loop; other site
395491014609	H-loop/switch region; other site
395491014610	TOBE domain; Region: TOBE_2; pfam08402
395491014611	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491014612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014613	dimer interface [polypeptide binding]; other site
395491014614	conserved gate region; other site
395491014615	putative PBP binding loops; other site
395491014616	ABC-ATPase subunit interface; other site
395491014617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014618	dimer interface [polypeptide binding]; other site
395491014619	conserved gate region; other site
395491014620	putative PBP binding loops; other site
395491014621	ABC-ATPase subunit interface; other site
395491014622	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
395491014623	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395491014624	agmatinase; Region: agmatinase; TIGR01230
395491014625	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
395491014626	oligomer interface [polypeptide binding]; other site
395491014627	putative active site [active]
395491014628	Mn binding site [ion binding]; other site
395491014629	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491014630	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491014631	substrate binding pocket [chemical binding]; other site
395491014632	membrane-bound complex binding site; other site
395491014633	hinge residues; other site
395491014634	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491014635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014636	dimer interface [polypeptide binding]; other site
395491014637	conserved gate region; other site
395491014638	putative PBP binding loops; other site
395491014639	ABC-ATPase subunit interface; other site
395491014640	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491014641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014642	dimer interface [polypeptide binding]; other site
395491014643	conserved gate region; other site
395491014644	putative PBP binding loops; other site
395491014645	ABC-ATPase subunit interface; other site
395491014646	ornithine cyclodeaminase; Validated; Region: PRK06141
395491014647	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
395491014648	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491014649	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491014650	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491014651	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491014652	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395491014653	dimerization interface [polypeptide binding]; other site
395491014654	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
395491014655	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
395491014656	Flavoprotein; Region: Flavoprotein; pfam02441
395491014657	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
395491014658	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
395491014659	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
395491014660	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
395491014661	tetramer interface [polypeptide binding]; other site
395491014662	active site
395491014663	Mg2+/Mn2+ binding site [ion binding]; other site
395491014664	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491014665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014666	dimer interface [polypeptide binding]; other site
395491014667	conserved gate region; other site
395491014668	putative PBP binding loops; other site
395491014669	ABC-ATPase subunit interface; other site
395491014670	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491014671	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014672	dimer interface [polypeptide binding]; other site
395491014673	conserved gate region; other site
395491014674	putative PBP binding loops; other site
395491014675	ABC-ATPase subunit interface; other site
395491014676	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
395491014677	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491014678	Walker A/P-loop; other site
395491014679	ATP binding site [chemical binding]; other site
395491014680	Q-loop/lid; other site
395491014681	ABC transporter signature motif; other site
395491014682	Walker B; other site
395491014683	D-loop; other site
395491014684	H-loop/switch region; other site
395491014685	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491014686	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
395491014687	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491014688	Walker A/P-loop; other site
395491014689	ATP binding site [chemical binding]; other site
395491014690	Q-loop/lid; other site
395491014691	ABC transporter signature motif; other site
395491014692	Walker B; other site
395491014693	D-loop; other site
395491014694	H-loop/switch region; other site
395491014695	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491014696	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
395491014697	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
395491014698	active sites [active]
395491014699	tetramer interface [polypeptide binding]; other site
395491014700	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
395491014701	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491014702	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491014703	homodimer interface [polypeptide binding]; other site
395491014704	catalytic residue [active]
395491014705	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
395491014706	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491014707	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491014708	active site
395491014709	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
395491014710	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
395491014711	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
395491014712	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
395491014713	DctM-like transporters; Region: DctM; pfam06808
395491014714	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
395491014715	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
395491014716	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395491014717	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395491014718	catalytic residue [active]
395491014719	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491014720	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491014721	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491014722	dimerization interface [polypeptide binding]; other site
395491014723	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
395491014724	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
395491014725	Predicted methyltransferase [General function prediction only]; Region: COG3897
395491014726	Putative methyltransferase; Region: Methyltransf_16; pfam10294
395491014727	EVE domain; Region: EVE; cl00728
395491014728	YciI-like protein; Reviewed; Region: PRK12865
395491014729	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
395491014730	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
395491014731	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
395491014732	UGMP family protein; Validated; Region: PRK09604
395491014733	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
395491014734	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
395491014735	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
395491014736	domain interfaces; other site
395491014737	active site
395491014738	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
395491014739	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
395491014740	active site
395491014741	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
395491014742	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
395491014743	HemY protein N-terminus; Region: HemY_N; pfam07219
395491014744	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
395491014745	putative metal binding site [ion binding]; other site
395491014746	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
395491014747	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
395491014748	catalytic triad [active]
395491014749	H+ Antiporter protein; Region: 2A0121; TIGR00900
395491014750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491014751	putative substrate translocation pore; other site
395491014752	YGGT family; Region: YGGT; pfam02325
395491014753	hypothetical protein; Validated; Region: PRK01310
395491014754	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
395491014755	dimer interface [polypeptide binding]; other site
395491014756	substrate binding site [chemical binding]; other site
395491014757	metal binding sites [ion binding]; metal-binding site
395491014758	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
395491014759	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491014760	Coenzyme A binding pocket [chemical binding]; other site
395491014761	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
395491014762	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
395491014763	G1 box; other site
395491014764	putative GEF interaction site [polypeptide binding]; other site
395491014765	GTP/Mg2+ binding site [chemical binding]; other site
395491014766	Switch I region; other site
395491014767	G2 box; other site
395491014768	G3 box; other site
395491014769	Switch II region; other site
395491014770	G4 box; other site
395491014771	G5 box; other site
395491014772	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
395491014773	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
395491014774	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
395491014775	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
395491014776	active site
395491014777	Zn binding site [ion binding]; other site
395491014778	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
395491014779	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491014780	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491014781	DNA binding site [nucleotide binding]
395491014782	Predicted ATPase [General function prediction only]; Region: COG3903
395491014783	OsmC-like protein; Region: OsmC; cl00767
395491014784	Epoxide hydrolase N terminus; Region: EHN; pfam06441
395491014785	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491014786	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
395491014787	Protein of unknown function (DUF3095); Region: DUF3095; pfam11294
395491014788	argininosuccinate synthase; Provisional; Region: PRK13820
395491014789	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
395491014790	ANP binding site [chemical binding]; other site
395491014791	Substrate Binding Site II [chemical binding]; other site
395491014792	Substrate Binding Site I [chemical binding]; other site
395491014793	hypothetical protein; Provisional; Region: PRK06194
395491014794	classical (c) SDRs; Region: SDR_c; cd05233
395491014795	NAD(P) binding site [chemical binding]; other site
395491014796	active site
395491014797	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
395491014798	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
395491014799	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491014800	Walker A/P-loop; other site
395491014801	ATP binding site [chemical binding]; other site
395491014802	Q-loop/lid; other site
395491014803	ABC transporter signature motif; other site
395491014804	Walker B; other site
395491014805	D-loop; other site
395491014806	H-loop/switch region; other site
395491014807	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491014808	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
395491014809	TM-ABC transporter signature motif; other site
395491014810	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
395491014811	zinc binding site [ion binding]; other site
395491014812	putative ligand binding site [chemical binding]; other site
395491014813	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
395491014814	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395491014815	FeS/SAM binding site; other site
395491014816	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
395491014817	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491014818	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491014819	DNA binding residues [nucleotide binding]
395491014820	Uncharacterized conserved protein [Function unknown]; Region: COG3339
395491014821	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
395491014822	aromatic arch; other site
395491014823	DCoH dimer interaction site [polypeptide binding]; other site
395491014824	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
395491014825	DCoH tetramer interaction site [polypeptide binding]; other site
395491014826	substrate binding site [chemical binding]; other site
395491014827	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
395491014828	Low molecular weight phosphatase family; Region: LMWPc; cd00115
395491014829	active site
395491014830	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
395491014831	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
395491014832	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
395491014833	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
395491014834	active site
395491014835	catalytic triad [active]
395491014836	oxyanion hole [active]
395491014837	switch loop; other site
395491014838	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
395491014839	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395491014840	Walker A/P-loop; other site
395491014841	ATP binding site [chemical binding]; other site
395491014842	Q-loop/lid; other site
395491014843	ABC transporter signature motif; other site
395491014844	Walker B; other site
395491014845	D-loop; other site
395491014846	H-loop/switch region; other site
395491014847	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
395491014848	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395491014849	FtsX-like permease family; Region: FtsX; pfam02687
395491014850	FtsX-like permease family; Region: FtsX; pfam02687
395491014851	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
395491014852	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
395491014853	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
395491014854	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491014855	Coenzyme A binding pocket [chemical binding]; other site
395491014856	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
395491014857	Uncharacterized secreted protein [Function unknown]; Region: COG5429
395491014858	aconitate hydratase; Validated; Region: PRK09277
395491014859	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
395491014860	substrate binding site [chemical binding]; other site
395491014861	ligand binding site [chemical binding]; other site
395491014862	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
395491014863	substrate binding site [chemical binding]; other site
395491014864	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
395491014865	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491014866	Walker A/P-loop; other site
395491014867	ATP binding site [chemical binding]; other site
395491014868	Q-loop/lid; other site
395491014869	ABC transporter signature motif; other site
395491014870	Walker B; other site
395491014871	D-loop; other site
395491014872	H-loop/switch region; other site
395491014873	heme exporter protein CcmB; Region: ccmB; TIGR01190
395491014874	heme exporter protein CcmC; Region: ccmC; TIGR01191
395491014875	Heme exporter protein D (CcmD); Region: CcmD; pfam04995
395491014876	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
395491014877	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
395491014878	catalytic residues [active]
395491014879	central insert; other site
395491014880	hypothetical protein; Provisional; Region: PRK00944
395491014881	intracellular septation protein A; Reviewed; Region: PRK00259
395491014882	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
395491014883	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
395491014884	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395491014885	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
395491014886	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
395491014887	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395491014888	FeS/SAM binding site; other site
395491014889	TRAM domain; Region: TRAM; cl01282
395491014890	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
395491014891	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
395491014892	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
395491014893	signal recognition particle protein; Provisional; Region: PRK10867
395491014894	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
395491014895	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
395491014896	P loop; other site
395491014897	GTP binding site [chemical binding]; other site
395491014898	Signal peptide binding domain; Region: SRP_SPB; pfam02978
395491014899	chorismate mutase; Provisional; Region: PRK09239
395491014900	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
395491014901	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
395491014902	RimM N-terminal domain; Region: RimM; pfam01782
395491014903	PRC-barrel domain; Region: PRC; pfam05239
395491014904	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
395491014905	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
395491014906	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491014907	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491014908	substrate binding pocket [chemical binding]; other site
395491014909	membrane-bound complex binding site; other site
395491014910	hinge residues; other site
395491014911	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014912	dimer interface [polypeptide binding]; other site
395491014913	conserved gate region; other site
395491014914	putative PBP binding loops; other site
395491014915	ABC-ATPase subunit interface; other site
395491014916	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
395491014917	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
395491014918	substrate binding site [chemical binding]; other site
395491014919	ligand binding site [chemical binding]; other site
395491014920	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491014921	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491014922	active site
395491014923	catalytic tetrad [active]
395491014924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
395491014925	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491014926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491014927	active site
395491014928	phosphorylation site [posttranslational modification]
395491014929	intermolecular recognition site; other site
395491014930	dimerization interface [polypeptide binding]; other site
395491014931	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491014932	DNA binding site [nucleotide binding]
395491014933	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491014934	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491014935	ligand binding site [chemical binding]; other site
395491014936	flexible hinge region; other site
395491014937	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
395491014938	putative catalytic site [active]
395491014939	putative phosphate binding site [ion binding]; other site
395491014940	active site
395491014941	metal binding site A [ion binding]; metal-binding site
395491014942	DNA binding site [nucleotide binding]
395491014943	putative AP binding site [nucleotide binding]; other site
395491014944	putative metal binding site B [ion binding]; other site
395491014945	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
395491014946	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
395491014947	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
395491014948	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
395491014949	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
395491014950	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
395491014951	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
395491014952	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
395491014953	Nitrogen regulatory protein P-II; Region: P-II; smart00938
395491014954	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
395491014955	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
395491014956	active site
395491014957	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
395491014958	catalytic triad [active]
395491014959	dimer interface [polypeptide binding]; other site
395491014960	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
395491014961	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491014962	Uncharacterized conserved protein [Function unknown]; Region: COG2835
395491014963	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
395491014964	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
395491014965	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
395491014966	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491014967	TPR motif; other site
395491014968	binding surface
395491014969	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
395491014970	putative deacylase active site [active]
395491014971	Uncharacterized conserved protein [Function unknown]; Region: COG5476
395491014972	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
395491014973	MlrC C-terminus; Region: MlrC_C; pfam07171
395491014974	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491014975	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491014976	DNA-binding site [nucleotide binding]; DNA binding site
395491014977	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
395491014978	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491014979	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511
395491014980	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491014981	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014982	dimer interface [polypeptide binding]; other site
395491014983	conserved gate region; other site
395491014984	putative PBP binding loops; other site
395491014985	ABC-ATPase subunit interface; other site
395491014986	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491014987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491014988	dimer interface [polypeptide binding]; other site
395491014989	conserved gate region; other site
395491014990	putative PBP binding loops; other site
395491014991	ABC-ATPase subunit interface; other site
395491014992	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
395491014993	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
395491014994	Uncharacterized conserved protein [Function unknown]; Region: COG3342
395491014995	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
395491014996	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395491014997	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491014998	Walker A/P-loop; other site
395491014999	ATP binding site [chemical binding]; other site
395491015000	Q-loop/lid; other site
395491015001	ABC transporter signature motif; other site
395491015002	Walker B; other site
395491015003	D-loop; other site
395491015004	H-loop/switch region; other site
395491015005	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
395491015006	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491015007	Walker A/P-loop; other site
395491015008	ATP binding site [chemical binding]; other site
395491015009	Q-loop/lid; other site
395491015010	ABC transporter signature motif; other site
395491015011	Walker B; other site
395491015012	D-loop; other site
395491015013	H-loop/switch region; other site
395491015014	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
395491015015	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
395491015016	Putative glucoamylase; Region: Glycoamylase; pfam10091
395491015017	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395491015018	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
395491015019	Walker A/P-loop; other site
395491015020	ATP binding site [chemical binding]; other site
395491015021	Q-loop/lid; other site
395491015022	ABC transporter signature motif; other site
395491015023	Walker B; other site
395491015024	D-loop; other site
395491015025	H-loop/switch region; other site
395491015026	TOBE domain; Region: TOBE_2; pfam08402
395491015027	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
395491015028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491015029	dimer interface [polypeptide binding]; other site
395491015030	conserved gate region; other site
395491015031	putative PBP binding loops; other site
395491015032	ABC-ATPase subunit interface; other site
395491015033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491015034	dimer interface [polypeptide binding]; other site
395491015035	conserved gate region; other site
395491015036	putative PBP binding loops; other site
395491015037	ABC-ATPase subunit interface; other site
395491015038	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395491015039	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395491015040	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
395491015041	aldehyde dehydrogenase family 7 member; Region: PLN02315
395491015042	tetrameric interface [polypeptide binding]; other site
395491015043	NAD binding site [chemical binding]; other site
395491015044	catalytic residues [active]
395491015045	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
395491015046	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491015047	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
395491015048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
395491015049	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491015050	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491015051	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
395491015052	dimerization interface [polypeptide binding]; other site
395491015053	substrate binding pocket [chemical binding]; other site
395491015054	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491015055	AsnC family; Region: AsnC_trans_reg; pfam01037
395491015056	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491015057	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395491015058	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
395491015059	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
395491015060	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
395491015061	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
395491015062	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491015063	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395491015064	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
395491015065	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
395491015066	Domain of unknown function (DUF1839); Region: DUF1839; pfam08893
395491015067	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
395491015068	dimer interface [polypeptide binding]; other site
395491015069	motif 1; other site
395491015070	active site
395491015071	motif 2; other site
395491015072	motif 3; other site
395491015073	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395491015074	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395491015075	active site
395491015076	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395491015077	active site
395491015078	acyl carrier protein; Provisional; Region: PRK07081
395491015079	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
395491015080	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395491015081	FeS/SAM binding site; other site
395491015082	Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269
395491015083	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395491015084	motif 1; other site
395491015085	dimer interface [polypeptide binding]; other site
395491015086	active site
395491015087	motif 2; other site
395491015088	motif 3; other site
395491015089	elongation factor P; Validated; Region: PRK00529
395491015090	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
395491015091	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
395491015092	RNA binding site [nucleotide binding]; other site
395491015093	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
395491015094	RNA binding site [nucleotide binding]; other site
395491015095	hypothetical protein; Provisional; Region: PRK02947
395491015096	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
395491015097	putative active site [active]
395491015098	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
395491015099	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
395491015100	active site
395491015101	dimer interface [polypeptide binding]; other site
395491015102	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
395491015103	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
395491015104	dimer interface [polypeptide binding]; other site
395491015105	active site
395491015106	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
395491015107	dimer interface [polypeptide binding]; other site
395491015108	active site
395491015109	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
395491015110	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491015111	DNA-binding site [nucleotide binding]; DNA binding site
395491015112	UTRA domain; Region: UTRA; pfam07702
395491015113	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
395491015114	active site
395491015115	catalytic residues [active]
395491015116	homoserine O-succinyltransferase; Provisional; Region: PRK05368
395491015117	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
395491015118	proposed active site lysine [active]
395491015119	conserved cys residue [active]
395491015120	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
395491015121	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
395491015122	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
395491015123	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
395491015124	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395491015125	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395491015126	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
395491015127	Thiamine pyrophosphokinase; Region: TPK; cd07995
395491015128	active site
395491015129	dimerization interface [polypeptide binding]; other site
395491015130	thiamine binding site [chemical binding]; other site
395491015131	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491015132	MarR family; Region: MarR_2; pfam12802
395491015133	MarR family; Region: MarR_2; cl17246
395491015134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491015135	putative substrate translocation pore; other site
395491015136	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491015137	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
395491015138	Peptidase family M48; Region: Peptidase_M48; pfam01435
395491015139	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
395491015140	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491015141	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491015142	DNA binding residues [nucleotide binding]
395491015143	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
395491015144	Ferredoxin [Energy production and conversion]; Region: COG1146
395491015145	4Fe-4S binding domain; Region: Fer4; cl02805
395491015146	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
395491015147	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395491015148	RNA binding surface [nucleotide binding]; other site
395491015149	DEAD/DEAH box helicase; Region: DEAD; pfam00270
395491015150	ATP binding site [chemical binding]; other site
395491015151	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
395491015152	putative Mg++ binding site [ion binding]; other site
395491015153	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491015154	nucleotide binding region [chemical binding]; other site
395491015155	ATP-binding site [chemical binding]; other site
395491015156	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
395491015157	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
395491015158	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
395491015159	NAD(P) binding site [chemical binding]; other site
395491015160	homotetramer interface [polypeptide binding]; other site
395491015161	homodimer interface [polypeptide binding]; other site
395491015162	active site
395491015163	putative acyltransferase; Provisional; Region: PRK05790
395491015164	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
395491015165	dimer interface [polypeptide binding]; other site
395491015166	active site
395491015167	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
395491015168	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
395491015169	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
395491015170	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
395491015171	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
395491015172	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491015173	putative C-terminal domain interface [polypeptide binding]; other site
395491015174	putative GSH binding site (G-site) [chemical binding]; other site
395491015175	putative dimer interface [polypeptide binding]; other site
395491015176	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
395491015177	putative N-terminal domain interface [polypeptide binding]; other site
395491015178	putative dimer interface [polypeptide binding]; other site
395491015179	putative substrate binding pocket (H-site) [chemical binding]; other site
395491015180	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
395491015181	Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975
395491015182	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
395491015183	Transglycosylase; Region: Transgly; cl17702
395491015184	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
395491015185	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
395491015186	substrate binding pocket [chemical binding]; other site
395491015187	chain length determination region; other site
395491015188	substrate-Mg2+ binding site; other site
395491015189	catalytic residues [active]
395491015190	aspartate-rich region 1; other site
395491015191	active site lid residues [active]
395491015192	aspartate-rich region 2; other site
395491015193	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
395491015194	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491015195	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491015196	homodimer interface [polypeptide binding]; other site
395491015197	catalytic residue [active]
395491015198	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
395491015199	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
395491015200	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
395491015201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491015202	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491015203	putative substrate translocation pore; other site
395491015204	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
395491015205	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
395491015206	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
395491015207	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395491015208	EamA-like transporter family; Region: EamA; pfam00892
395491015209	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491015210	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491015211	substrate binding pocket [chemical binding]; other site
395491015212	membrane-bound complex binding site; other site
395491015213	hinge residues; other site
395491015214	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491015215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491015216	dimer interface [polypeptide binding]; other site
395491015217	conserved gate region; other site
395491015218	putative PBP binding loops; other site
395491015219	ABC-ATPase subunit interface; other site
395491015220	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395491015221	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491015222	Walker A/P-loop; other site
395491015223	ATP binding site [chemical binding]; other site
395491015224	Q-loop/lid; other site
395491015225	ABC transporter signature motif; other site
395491015226	Walker B; other site
395491015227	D-loop; other site
395491015228	H-loop/switch region; other site
395491015229	Predicted flavoprotein [General function prediction only]; Region: COG0431
395491015230	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491015231	pyruvate carboxylase; Reviewed; Region: PRK12999
395491015232	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395491015233	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395491015234	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
395491015235	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
395491015236	active site
395491015237	catalytic residues [active]
395491015238	metal binding site [ion binding]; metal-binding site
395491015239	homodimer binding site [polypeptide binding]; other site
395491015240	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395491015241	carboxyltransferase (CT) interaction site; other site
395491015242	biotinylation site [posttranslational modification]; other site
395491015243	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
395491015244	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395491015245	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491015246	DNA binding residues [nucleotide binding]
395491015247	dimerization interface [polypeptide binding]; other site
395491015248	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
395491015249	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491015250	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
395491015251	Walker A/P-loop; other site
395491015252	ATP binding site [chemical binding]; other site
395491015253	Q-loop/lid; other site
395491015254	ABC transporter signature motif; other site
395491015255	Walker B; other site
395491015256	D-loop; other site
395491015257	H-loop/switch region; other site
395491015258	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395491015259	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
395491015260	dimer interface [polypeptide binding]; other site
395491015261	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491015262	OpgC protein; Region: OpgC_C; pfam10129
395491015263	Acyltransferase family; Region: Acyl_transf_3; pfam01757
395491015264	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
395491015265	Putative glucoamylase; Region: Glycoamylase; pfam10091
395491015266	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
395491015267	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
395491015268	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
395491015269	Protein of unknown function, DUF608; Region: DUF608; pfam04685
395491015270	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491015271	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491015272	Walker A/P-loop; other site
395491015273	ATP binding site [chemical binding]; other site
395491015274	Q-loop/lid; other site
395491015275	ABC transporter signature motif; other site
395491015276	Walker B; other site
395491015277	D-loop; other site
395491015278	H-loop/switch region; other site
395491015279	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491015280	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491015281	Walker A/P-loop; other site
395491015282	ATP binding site [chemical binding]; other site
395491015283	Q-loop/lid; other site
395491015284	ABC transporter signature motif; other site
395491015285	Walker B; other site
395491015286	D-loop; other site
395491015287	H-loop/switch region; other site
395491015288	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491015289	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
395491015290	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491015291	dimer interface [polypeptide binding]; other site
395491015292	conserved gate region; other site
395491015293	putative PBP binding loops; other site
395491015294	ABC-ATPase subunit interface; other site
395491015295	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491015296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491015297	putative PBP binding loops; other site
395491015298	ABC-ATPase subunit interface; other site
395491015299	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491015300	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
395491015301	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
395491015302	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
395491015303	active site
395491015304	dimer interface [polypeptide binding]; other site
395491015305	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491015306	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491015307	TM-ABC transporter signature motif; other site
395491015308	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491015309	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491015310	Walker A/P-loop; other site
395491015311	ATP binding site [chemical binding]; other site
395491015312	Q-loop/lid; other site
395491015313	ABC transporter signature motif; other site
395491015314	Walker B; other site
395491015315	D-loop; other site
395491015316	H-loop/switch region; other site
395491015317	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491015318	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491015319	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
395491015320	putative ligand binding site [chemical binding]; other site
395491015321	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
395491015322	Sulfatase; Region: Sulfatase; cl17466
395491015323	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395491015324	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
395491015325	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
395491015326	NAD binding site [chemical binding]; other site
395491015327	homodimer interface [polypeptide binding]; other site
395491015328	active site
395491015329	substrate binding site [chemical binding]; other site
395491015330	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
395491015331	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491015332	Coenzyme A binding pocket [chemical binding]; other site
395491015333	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
395491015334	Thioredoxin; Region: Thioredoxin_4; cl17273
395491015335	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
395491015336	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
395491015337	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
395491015338	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395491015339	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395491015340	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395491015341	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395491015342	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
395491015343	putative catalytic site [active]
395491015344	putative metal binding site [ion binding]; other site
395491015345	putative phosphate binding site [ion binding]; other site
395491015346	GTPase CgtA; Reviewed; Region: obgE; PRK12299
395491015347	GTP1/OBG; Region: GTP1_OBG; pfam01018
395491015348	Obg GTPase; Region: Obg; cd01898
395491015349	G1 box; other site
395491015350	GTP/Mg2+ binding site [chemical binding]; other site
395491015351	Switch I region; other site
395491015352	G2 box; other site
395491015353	G3 box; other site
395491015354	Switch II region; other site
395491015355	G4 box; other site
395491015356	G5 box; other site
395491015357	gamma-glutamyl kinase; Provisional; Region: PRK05429
395491015358	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
395491015359	nucleotide binding site [chemical binding]; other site
395491015360	homotetrameric interface [polypeptide binding]; other site
395491015361	putative phosphate binding site [ion binding]; other site
395491015362	putative allosteric binding site; other site
395491015363	PUA domain; Region: PUA; pfam01472
395491015364	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
395491015365	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
395491015366	putative catalytic cysteine [active]
395491015367	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
395491015368	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
395491015369	active site
395491015370	(T/H)XGH motif; other site
395491015371	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
395491015372	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395491015373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491015374	dimer interface [polypeptide binding]; other site
395491015375	conserved gate region; other site
395491015376	putative PBP binding loops; other site
395491015377	ABC-ATPase subunit interface; other site
395491015378	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491015379	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
395491015380	Walker A/P-loop; other site
395491015381	ATP binding site [chemical binding]; other site
395491015382	Q-loop/lid; other site
395491015383	ABC transporter signature motif; other site
395491015384	Walker B; other site
395491015385	D-loop; other site
395491015386	H-loop/switch region; other site
395491015387	TOBE domain; Region: TOBE; pfam03459
395491015388	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
395491015389	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
395491015390	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
395491015391	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
395491015392	Peptidase family M23; Region: Peptidase_M23; pfam01551
395491015393	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
395491015394	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
395491015395	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
395491015396	protein binding site [polypeptide binding]; other site
395491015397	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
395491015398	Catalytic dyad [active]
395491015399	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
395491015400	NodB motif; other site
395491015401	putative active site [active]
395491015402	putative catalytic site [active]
395491015403	Zn binding site [ion binding]; other site
395491015404	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
395491015405	putative active site [active]
395491015406	Ap4A binding site [chemical binding]; other site
395491015407	nudix motif; other site
395491015408	putative metal binding site [ion binding]; other site
395491015409	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
395491015410	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
395491015411	heme binding site [chemical binding]; other site
395491015412	ferroxidase pore; other site
395491015413	ferroxidase diiron center [ion binding]; other site
395491015414	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
395491015415	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
395491015416	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
395491015417	putative active site [active]
395491015418	putative PHP Thumb interface [polypeptide binding]; other site
395491015419	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
395491015420	generic binding surface II; other site
395491015421	generic binding surface I; other site
395491015422	Uncharacterized conserved protein [Function unknown]; Region: COG4544
395491015423	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
395491015424	Uncharacterized conserved small protein [Function unknown]; Region: COG5515
395491015425	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
395491015426	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
395491015427	putative dimer interface [polypeptide binding]; other site
395491015428	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491015429	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
395491015430	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
395491015431	substrate binding site [chemical binding]; other site
395491015432	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
395491015433	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
395491015434	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395491015435	catalytic residue [active]
395491015436	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
395491015437	tartrate dehydrogenase; Region: TTC; TIGR02089
395491015438	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
395491015439	active site
395491015440	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491015441	putative substrate translocation pore; other site
395491015442	FtsX-like permease family; Region: FtsX; pfam02687
395491015443	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395491015444	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
395491015445	Walker A/P-loop; other site
395491015446	ATP binding site [chemical binding]; other site
395491015447	Q-loop/lid; other site
395491015448	ABC transporter signature motif; other site
395491015449	Walker B; other site
395491015450	D-loop; other site
395491015451	H-loop/switch region; other site
395491015452	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
395491015453	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
395491015454	dimer interface [polypeptide binding]; other site
395491015455	active site
395491015456	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
395491015457	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
395491015458	Transglycosylase SLT domain; Region: SLT_2; pfam13406
395491015459	murein hydrolase B; Provisional; Region: PRK10760; cl17906
395491015460	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491015461	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491015462	metal binding site [ion binding]; metal-binding site
395491015463	active site
395491015464	I-site; other site
395491015465	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
395491015466	active site clefts [active]
395491015467	zinc binding site [ion binding]; other site
395491015468	dimer interface [polypeptide binding]; other site
395491015469	pyridoxamine kinase; Validated; Region: PRK05756
395491015470	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
395491015471	pyridoxal binding site [chemical binding]; other site
395491015472	dimer interface [polypeptide binding]; other site
395491015473	ATP binding site [chemical binding]; other site
395491015474	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
395491015475	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
395491015476	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
395491015477	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
395491015478	purine monophosphate binding site [chemical binding]; other site
395491015479	dimer interface [polypeptide binding]; other site
395491015480	putative catalytic residues [active]
395491015481	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
395491015482	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
395491015483	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
395491015484	NusB family; Region: NusB; pfam01029
395491015485	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
395491015486	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
395491015487	heat shock protein HtpX; Provisional; Region: PRK01345
395491015488	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
395491015489	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
395491015490	acetyl-CoA synthetase; Provisional; Region: PRK00174
395491015491	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
395491015492	active site
395491015493	CoA binding site [chemical binding]; other site
395491015494	acyl-activating enzyme (AAE) consensus motif; other site
395491015495	AMP binding site [chemical binding]; other site
395491015496	acetate binding site [chemical binding]; other site
395491015497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
395491015498	flagellin; Reviewed; Region: PRK12687
395491015499	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395491015500	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395491015501	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
395491015502	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
395491015503	acyl-activating enzyme (AAE) consensus motif; other site
395491015504	putative AMP binding site [chemical binding]; other site
395491015505	putative active site [active]
395491015506	putative CoA binding site [chemical binding]; other site
395491015507	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
395491015508	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395491015509	catalytic residue [active]
395491015510	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
395491015511	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
395491015512	HIGH motif; other site
395491015513	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
395491015514	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395491015515	active site
395491015516	KMSKS motif; other site
395491015517	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
395491015518	tRNA binding surface [nucleotide binding]; other site
395491015519	Lipopolysaccharide-assembly; Region: LptE; cl01125
395491015520	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
395491015521	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
395491015522	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
395491015523	ParB-like nuclease domain; Region: ParBc; pfam02195
395491015524	KorB domain; Region: KorB; pfam08535
395491015525	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
395491015526	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491015527	P-loop; other site
395491015528	Magnesium ion binding site [ion binding]; other site
395491015529	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491015530	Magnesium ion binding site [ion binding]; other site
395491015531	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
395491015532	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
395491015533	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
395491015534	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
395491015535	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
395491015536	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
395491015537	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
395491015538	trmE is a tRNA modification GTPase; Region: trmE; cd04164
395491015539	G1 box; other site
395491015540	GTP/Mg2+ binding site [chemical binding]; other site
395491015541	Switch I region; other site
395491015542	G2 box; other site
395491015543	Switch II region; other site
395491015544	G3 box; other site
395491015545	G4 box; other site
395491015546	G5 box; other site
395491015547	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
395491015548	transcription termination factor Rho; Provisional; Region: rho; PRK09376
395491015549	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
395491015550	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
395491015551	RNA binding site [nucleotide binding]; other site
395491015552	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
395491015553	multimer interface [polypeptide binding]; other site
395491015554	Walker A motif; other site
395491015555	ATP binding site [chemical binding]; other site
395491015556	Walker B motif; other site
395491015557	Predicted membrane protein [Function unknown]; Region: COG1981
395491015558	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
395491015559	substrate binding site [chemical binding]; other site
395491015560	active site
395491015561	PEP synthetase regulatory protein; Provisional; Region: PRK05339
395491015562	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
395491015563	active site
395491015564	dimer interface [polypeptide binding]; other site
395491015565	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
395491015566	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
395491015567	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
395491015568	shikimate binding site; other site
395491015569	NAD(P) binding site [chemical binding]; other site
395491015570	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
395491015571	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
395491015572	CoA-binding site [chemical binding]; other site
395491015573	ATP-binding [chemical binding]; other site
395491015574	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
395491015575	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
395491015576	active site
395491015577	catalytic site [active]
395491015578	substrate binding site [chemical binding]; other site
395491015579	preprotein translocase subunit SecB; Validated; Region: PRK05751
395491015580	SecA binding site; other site
395491015581	Preprotein binding site; other site
395491015582	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
395491015583	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
395491015584	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
395491015585	MltA specific insert domain; Region: MltA; smart00925
395491015586	3D domain; Region: 3D; pfam06725
395491015587	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
395491015588	Smr domain; Region: Smr; pfam01713
395491015589	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491015590	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491015591	non-specific DNA binding site [nucleotide binding]; other site
395491015592	salt bridge; other site
395491015593	sequence-specific DNA binding site [nucleotide binding]; other site
395491015594	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
395491015595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491015596	Mg2+ binding site [ion binding]; other site
395491015597	G-X-G motif; other site
395491015598	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
395491015599	anchoring element; other site
395491015600	dimer interface [polypeptide binding]; other site
395491015601	ATP binding site [chemical binding]; other site
395491015602	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
395491015603	active site
395491015604	putative metal-binding site [ion binding]; other site
395491015605	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
395491015606	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
395491015607	putative FMN binding site [chemical binding]; other site
395491015608	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
395491015609	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
395491015610	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
395491015611	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
395491015612	putative dimer interface [polypeptide binding]; other site
395491015613	N-terminal domain interface [polypeptide binding]; other site
395491015614	putative substrate binding pocket (H-site) [chemical binding]; other site
395491015615	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
395491015616	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
395491015617	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
395491015618	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
395491015619	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
395491015620	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
395491015621	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
395491015622	active site
395491015623	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
395491015624	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
395491015625	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491015626	catalytic residue [active]
395491015627	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
395491015628	substrate binding site [chemical binding]; other site
395491015629	active site
395491015630	catalytic residues [active]
395491015631	heterodimer interface [polypeptide binding]; other site
395491015632	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
395491015633	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
395491015634	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
395491015635	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395491015636	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395491015637	catalytic residues [active]
395491015638	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
395491015639	Part of AAA domain; Region: AAA_19; pfam13245
395491015640	Family description; Region: UvrD_C_2; pfam13538
395491015641	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
395491015642	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
395491015643	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
395491015644	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
395491015645	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
395491015646	Substrate binding site; other site
395491015647	metal-binding site
395491015648	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
395491015649	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
395491015650	Phosphotransferase enzyme family; Region: APH; pfam01636
395491015651	PAS fold; Region: PAS_7; pfam12860
395491015652	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395491015653	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491015654	dimer interface [polypeptide binding]; other site
395491015655	phosphorylation site [posttranslational modification]
395491015656	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491015657	ATP binding site [chemical binding]; other site
395491015658	Mg2+ binding site [ion binding]; other site
395491015659	G-X-G motif; other site
395491015660	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
395491015661	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
395491015662	homotetramer interface [polypeptide binding]; other site
395491015663	ligand binding site [chemical binding]; other site
395491015664	catalytic site [active]
395491015665	NAD binding site [chemical binding]; other site
395491015666	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
395491015667	dimerization domain swap beta strand [polypeptide binding]; other site
395491015668	regulatory protein interface [polypeptide binding]; other site
395491015669	active site
395491015670	regulatory phosphorylation site [posttranslational modification]; other site
395491015671	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
395491015672	active pocket/dimerization site; other site
395491015673	active site
395491015674	phosphorylation site [posttranslational modification]
395491015675	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
395491015676	Hpr binding site; other site
395491015677	active site
395491015678	homohexamer subunit interaction site [polypeptide binding]; other site
395491015679	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
395491015680	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
395491015681	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
395491015682	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491015683	dimerization interface [polypeptide binding]; other site
395491015684	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491015685	dimer interface [polypeptide binding]; other site
395491015686	phosphorylation site [posttranslational modification]
395491015687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491015688	ATP binding site [chemical binding]; other site
395491015689	Mg2+ binding site [ion binding]; other site
395491015690	G-X-G motif; other site
395491015691	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491015692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491015693	active site
395491015694	phosphorylation site [posttranslational modification]
395491015695	intermolecular recognition site; other site
395491015696	dimerization interface [polypeptide binding]; other site
395491015697	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491015698	DNA binding site [nucleotide binding]
395491015699	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
395491015700	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
395491015701	active site
395491015702	substrate-binding site [chemical binding]; other site
395491015703	metal-binding site [ion binding]
395491015704	ATP binding site [chemical binding]; other site
395491015705	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
395491015706	hypothetical protein; Provisional; Region: PRK09256
395491015707	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
395491015708	pantothenate kinase; Provisional; Region: PRK05439
395491015709	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
395491015710	ATP-binding site [chemical binding]; other site
395491015711	CoA-binding site [chemical binding]; other site
395491015712	Mg2+-binding site [ion binding]; other site
395491015713	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
395491015714	metal binding site [ion binding]; metal-binding site
395491015715	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
395491015716	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
395491015717	substrate binding site [chemical binding]; other site
395491015718	glutamase interaction surface [polypeptide binding]; other site
395491015719	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
395491015720	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
395491015721	catalytic residues [active]
395491015722	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
395491015723	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
395491015724	putative active site [active]
395491015725	oxyanion strand; other site
395491015726	catalytic triad [active]
395491015727	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
395491015728	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
395491015729	putative active site pocket [active]
395491015730	4-fold oligomerization interface [polypeptide binding]; other site
395491015731	metal binding residues [ion binding]; metal-binding site
395491015732	3-fold/trimer interface [polypeptide binding]; other site
395491015733	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
395491015734	active site
395491015735	HslU subunit interaction site [polypeptide binding]; other site
395491015736	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
395491015737	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
395491015738	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395491015739	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
395491015740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491015741	Walker A motif; other site
395491015742	ATP binding site [chemical binding]; other site
395491015743	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
395491015744	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
395491015745	Protein of unknown function (DUF1402); Region: DUF1402; pfam07182
395491015746	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
395491015747	Cytochrome P450; Region: p450; cl12078
395491015748	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
395491015749	active site
395491015750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395491015751	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491015752	Protein of unknown function (DUF1052); Region: DUF1052; pfam06319
395491015753	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
395491015754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491015755	active site
395491015756	phosphorylation site [posttranslational modification]
395491015757	intermolecular recognition site; other site
395491015758	dimerization interface [polypeptide binding]; other site
395491015759	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
395491015760	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491015761	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491015762	dimer interface [polypeptide binding]; other site
395491015763	phosphorylation site [posttranslational modification]
395491015764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491015765	ATP binding site [chemical binding]; other site
395491015766	Mg2+ binding site [ion binding]; other site
395491015767	G-X-G motif; other site
395491015768	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
395491015769	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395491015770	ATP binding site [chemical binding]; other site
395491015771	putative Mg++ binding site [ion binding]; other site
395491015772	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491015773	nucleotide binding region [chemical binding]; other site
395491015774	ATP-binding site [chemical binding]; other site
395491015775	Helicase associated domain (HA2); Region: HA2; pfam04408
395491015776	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
395491015777	ornithine cyclodeaminase; Validated; Region: PRK06141
395491015778	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
395491015779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395491015780	Walker A motif; other site
395491015781	ATP binding site [chemical binding]; other site
395491015782	Walker B motif; other site
395491015783	arginine finger; other site
395491015784	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
395491015785	AAA domain; Region: AAA_12; pfam13087
395491015786	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
395491015787	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395491015788	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491015789	binding surface
395491015790	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395491015791	TPR motif; other site
395491015792	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395491015793	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
395491015794	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491015795	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491015796	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
395491015797	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491015798	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
395491015799	Walker A/P-loop; other site
395491015800	ATP binding site [chemical binding]; other site
395491015801	Q-loop/lid; other site
395491015802	ABC transporter signature motif; other site
395491015803	Walker B; other site
395491015804	D-loop; other site
395491015805	H-loop/switch region; other site
395491015806	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491015807	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491015808	DNA binding residues [nucleotide binding]
395491015809	dimerization interface [polypeptide binding]; other site
395491015810	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
395491015811	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491015812	NAD binding site [chemical binding]; other site
395491015813	putative substrate binding site 2 [chemical binding]; other site
395491015814	putative substrate binding site 1 [chemical binding]; other site
395491015815	active site
395491015816	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
395491015817	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
395491015818	NAD binding site [chemical binding]; other site
395491015819	homodimer interface [polypeptide binding]; other site
395491015820	active site
395491015821	substrate binding site [chemical binding]; other site
395491015822	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
395491015823	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395491015824	active site
395491015825	Protein of unknown function (DUF995); Region: DUF995; pfam06191
395491015826	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
395491015827	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491015828	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491015829	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491015830	DNA binding site [nucleotide binding]
395491015831	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491015832	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491015833	ligand binding site [chemical binding]; other site
395491015834	dimerization interface [polypeptide binding]; other site
395491015835	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289
395491015836	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
395491015837	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
395491015838	putative ligand binding site [chemical binding]; other site
395491015839	putative NAD binding site [chemical binding]; other site
395491015840	catalytic site [active]
395491015841	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491015842	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491015843	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491015844	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491015845	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
395491015846	Protein of unknown function (DUF993); Region: DUF993; pfam06187
395491015847	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491015848	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491015849	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
395491015850	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491015851	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491015852	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491015853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491015854	dimer interface [polypeptide binding]; other site
395491015855	conserved gate region; other site
395491015856	putative PBP binding loops; other site
395491015857	ABC-ATPase subunit interface; other site
395491015858	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491015859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491015860	dimer interface [polypeptide binding]; other site
395491015861	conserved gate region; other site
395491015862	putative PBP binding loops; other site
395491015863	ABC-ATPase subunit interface; other site
395491015864	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491015865	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491015866	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491015867	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491015868	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491015869	Walker A/P-loop; other site
395491015870	ATP binding site [chemical binding]; other site
395491015871	Q-loop/lid; other site
395491015872	ABC transporter signature motif; other site
395491015873	Walker B; other site
395491015874	D-loop; other site
395491015875	H-loop/switch region; other site
395491015876	TOBE domain; Region: TOBE_2; pfam08402
395491015877	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
395491015878	Phosphotransferase enzyme family; Region: APH; pfam01636
395491015879	active site
395491015880	ATP binding site [chemical binding]; other site
395491015881	substrate binding site [chemical binding]; other site
395491015882	dimer interface [polypeptide binding]; other site
395491015883	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491015884	hydroxyglutarate oxidase; Provisional; Region: PRK11728
395491015885	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
395491015886	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
395491015887	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395491015888	Helix-turn-helix domain; Region: HTH_28; pfam13518
395491015889	Winged helix-turn helix; Region: HTH_29; pfam13551
395491015890	Homeodomain-like domain; Region: HTH_32; pfam13565
395491015891	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
395491015892	Integrase core domain; Region: rve; pfam00665
395491015893	Integrase core domain; Region: rve_3; pfam13683
395491015894	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
395491015895	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
395491015896	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
395491015897	glucuronate isomerase; Reviewed; Region: PRK02925
395491015898	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
395491015899	hypothetical protein; Provisional; Region: PRK00736
395491015900	succinic semialdehyde dehydrogenase; Region: PLN02278
395491015901	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
395491015902	tetramerization interface [polypeptide binding]; other site
395491015903	NAD(P) binding site [chemical binding]; other site
395491015904	catalytic residues [active]
395491015905	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
395491015906	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395491015907	inhibitor-cofactor binding pocket; inhibition site
395491015908	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491015909	catalytic residue [active]
395491015910	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
395491015911	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
395491015912	DNA binding residues [nucleotide binding]
395491015913	dimer interface [polypeptide binding]; other site
395491015914	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
395491015915	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491015916	non-specific DNA binding site [nucleotide binding]; other site
395491015917	salt bridge; other site
395491015918	sequence-specific DNA binding site [nucleotide binding]; other site
395491015919	Cupin domain; Region: Cupin_2; pfam07883
395491015920	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
395491015921	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
395491015922	catalytic site [active]
395491015923	putative active site [active]
395491015924	putative substrate binding site [chemical binding]; other site
395491015925	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
395491015926	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
395491015927	RNA binding site [nucleotide binding]; other site
395491015928	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
395491015929	RNA binding site [nucleotide binding]; other site
395491015930	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
395491015931	RNA binding site [nucleotide binding]; other site
395491015932	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
395491015933	RNA binding site [nucleotide binding]; other site
395491015934	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
395491015935	RNA binding site [nucleotide binding]; other site
395491015936	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
395491015937	RNA binding site [nucleotide binding]; other site
395491015938	cytidylate kinase; Provisional; Region: cmk; PRK00023
395491015939	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
395491015940	CMP-binding site; other site
395491015941	The sites determining sugar specificity; other site
395491015942	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
395491015943	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
395491015944	hinge; other site
395491015945	active site
395491015946	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
395491015947	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
395491015948	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
395491015949	GIY-YIG motif/motif A; other site
395491015950	putative active site [active]
395491015951	putative metal binding site [ion binding]; other site
395491015952	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
395491015953	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
395491015954	active site
395491015955	iron coordination sites [ion binding]; other site
395491015956	substrate binding pocket [chemical binding]; other site
395491015957	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
395491015958	Prostaglandin dehydrogenases; Region: PGDH; cd05288
395491015959	NAD(P) binding site [chemical binding]; other site
395491015960	substrate binding site [chemical binding]; other site
395491015961	dimer interface [polypeptide binding]; other site
395491015962	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395491015963	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491015964	substrate binding pocket [chemical binding]; other site
395491015965	membrane-bound complex binding site; other site
395491015966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
395491015967	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
395491015968	serine acetyltransferase; Provisional; Region: cysE; PRK11132
395491015969	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
395491015970	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
395491015971	trimer interface [polypeptide binding]; other site
395491015972	active site
395491015973	substrate binding site [chemical binding]; other site
395491015974	CoA binding site [chemical binding]; other site
395491015975	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
395491015976	Predicted membrane protein [Function unknown]; Region: COG3619
395491015977	Uncharacterized conserved protein [Function unknown]; Region: COG1434
395491015978	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
395491015979	putative active site [active]
395491015980	Predicted membrane protein [Function unknown]; Region: COG2860
395491015981	UPF0126 domain; Region: UPF0126; pfam03458
395491015982	UPF0126 domain; Region: UPF0126; pfam03458
395491015983	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395491015984	metal binding site 2 [ion binding]; metal-binding site
395491015985	putative DNA binding helix; other site
395491015986	metal binding site 1 [ion binding]; metal-binding site
395491015987	dimer interface [polypeptide binding]; other site
395491015988	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
395491015989	active site 1 [active]
395491015990	dimer interface [polypeptide binding]; other site
395491015991	active site 2 [active]
395491015992	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
395491015993	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395491015994	dimer interface [polypeptide binding]; other site
395491015995	active site
395491015996	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
395491015997	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
395491015998	NAD binding site [chemical binding]; other site
395491015999	homotetramer interface [polypeptide binding]; other site
395491016000	homodimer interface [polypeptide binding]; other site
395491016001	substrate binding site [chemical binding]; other site
395491016002	active site
395491016003	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
395491016004	Methyltransferase small domain; Region: MTS; pfam05175
395491016005	S-adenosylmethionine binding site [chemical binding]; other site
395491016006	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
395491016007	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
395491016008	RNase E interface [polypeptide binding]; other site
395491016009	trimer interface [polypeptide binding]; other site
395491016010	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
395491016011	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
395491016012	RNase E interface [polypeptide binding]; other site
395491016013	trimer interface [polypeptide binding]; other site
395491016014	active site
395491016015	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
395491016016	putative nucleic acid binding region [nucleotide binding]; other site
395491016017	G-X-X-G motif; other site
395491016018	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
395491016019	RNA binding site [nucleotide binding]; other site
395491016020	domain interface; other site
395491016021	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
395491016022	16S/18S rRNA binding site [nucleotide binding]; other site
395491016023	S13e-L30e interaction site [polypeptide binding]; other site
395491016024	25S rRNA binding site [nucleotide binding]; other site
395491016025	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491016026	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
395491016027	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
395491016028	RNA binding site [nucleotide binding]; other site
395491016029	active site
395491016030	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
395491016031	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
395491016032	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
395491016033	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
395491016034	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
395491016035	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
395491016036	G1 box; other site
395491016037	putative GEF interaction site [polypeptide binding]; other site
395491016038	GTP/Mg2+ binding site [chemical binding]; other site
395491016039	Switch I region; other site
395491016040	G2 box; other site
395491016041	G3 box; other site
395491016042	Switch II region; other site
395491016043	G4 box; other site
395491016044	G5 box; other site
395491016045	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
395491016046	Translation-initiation factor 2; Region: IF-2; pfam11987
395491016047	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
395491016048	hypothetical protein; Provisional; Region: PRK09190
395491016049	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
395491016050	putative RNA binding cleft [nucleotide binding]; other site
395491016051	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
395491016052	NusA N-terminal domain; Region: NusA_N; pfam08529
395491016053	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
395491016054	RNA binding site [nucleotide binding]; other site
395491016055	homodimer interface [polypeptide binding]; other site
395491016056	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
395491016057	G-X-X-G motif; other site
395491016058	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
395491016059	G-X-X-G motif; other site
395491016060	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
395491016061	ribosome maturation protein RimP; Reviewed; Region: PRK00092
395491016062	Sm and related proteins; Region: Sm_like; cl00259
395491016063	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
395491016064	putative oligomer interface [polypeptide binding]; other site
395491016065	putative RNA binding site [nucleotide binding]; other site
395491016066	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
395491016067	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491016068	Coenzyme A binding pocket [chemical binding]; other site
395491016069	Transglycosylase SLT domain; Region: SLT_2; pfam13406
395491016070	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395491016071	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395491016072	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491016073	recombination protein RecR; Reviewed; Region: recR; PRK00076
395491016074	RecR protein; Region: RecR; pfam02132
395491016075	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
395491016076	putative active site [active]
395491016077	putative metal-binding site [ion binding]; other site
395491016078	tetramer interface [polypeptide binding]; other site
395491016079	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
395491016080	MOSC domain; Region: MOSC; pfam03473
395491016081	hypothetical protein; Validated; Region: PRK00153
395491016082	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
395491016083	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491016084	Walker A motif; other site
395491016085	ATP binding site [chemical binding]; other site
395491016086	Walker B motif; other site
395491016087	arginine finger; other site
395491016088	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
395491016089	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
395491016090	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
395491016091	nucleotide binding site/active site [active]
395491016092	HIT family signature motif; other site
395491016093	catalytic residue [active]
395491016094	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
395491016095	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
395491016096	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
395491016097	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
395491016098	putative NADH binding site [chemical binding]; other site
395491016099	putative active site [active]
395491016100	nudix motif; other site
395491016101	putative metal binding site [ion binding]; other site
395491016102	HTH domain; Region: HTH_11; pfam08279
395491016103	Predicted transcriptional regulator [Transcription]; Region: COG2378
395491016104	WYL domain; Region: WYL; pfam13280
395491016105	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
395491016106	putative dimer interface [polypeptide binding]; other site
395491016107	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491016108	prephenate dehydratase; Provisional; Region: PRK11899
395491016109	Prephenate dehydratase; Region: PDT; pfam00800
395491016110	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
395491016111	putative L-Phe binding site [chemical binding]; other site
395491016112	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
395491016113	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
395491016114	Ligand binding site; other site
395491016115	oligomer interface; other site
395491016116	Cytochrome c2 [Energy production and conversion]; Region: COG3474
395491016117	Predicted permeases [General function prediction only]; Region: COG0679
395491016118	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
395491016119	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491016120	substrate binding site [chemical binding]; other site
395491016121	ATP binding site [chemical binding]; other site
395491016122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
395491016123	Bacterial SH3 domain; Region: SH3_4; pfam06347
395491016124	Bacterial SH3 domain; Region: SH3_4; pfam06347
395491016125	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
395491016126	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
395491016127	dimerization interface [polypeptide binding]; other site
395491016128	ligand binding site [chemical binding]; other site
395491016129	NADP binding site [chemical binding]; other site
395491016130	catalytic site [active]
395491016131	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491016132	Coenzyme A binding pocket [chemical binding]; other site
395491016133	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
395491016134	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
395491016135	ATP binding site [chemical binding]; other site
395491016136	substrate interface [chemical binding]; other site
395491016137	recombination protein F; Reviewed; Region: recF; PRK00064
395491016138	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
395491016139	Walker A/P-loop; other site
395491016140	ATP binding site [chemical binding]; other site
395491016141	Q-loop/lid; other site
395491016142	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491016143	ABC transporter signature motif; other site
395491016144	Walker B; other site
395491016145	D-loop; other site
395491016146	H-loop/switch region; other site
395491016147	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491016148	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491016149	non-specific DNA binding site [nucleotide binding]; other site
395491016150	salt bridge; other site
395491016151	sequence-specific DNA binding site [nucleotide binding]; other site
395491016152	chaperone protein DnaJ; Provisional; Region: PRK10767
395491016153	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395491016154	HSP70 interaction site [polypeptide binding]; other site
395491016155	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
395491016156	substrate binding site [polypeptide binding]; other site
395491016157	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
395491016158	Zn binding sites [ion binding]; other site
395491016159	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
395491016160	dimer interface [polypeptide binding]; other site
395491016161	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
395491016162	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
395491016163	nucleotide binding site [chemical binding]; other site
395491016164	NEF interaction site [polypeptide binding]; other site
395491016165	SBD interface [polypeptide binding]; other site
395491016166	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
395491016167	Transglycosylase; Region: Transgly; pfam00912
395491016168	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395491016169	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
395491016170	Bacterial SH3 domain; Region: SH3_3; pfam08239
395491016171	hypothetical protein; Validated; Region: PRK09104
395491016172	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
395491016173	metal binding site [ion binding]; metal-binding site
395491016174	putative dimer interface [polypeptide binding]; other site
395491016175	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
395491016176	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
395491016177	PAS domain S-box; Region: sensory_box; TIGR00229
395491016178	PAS domain; Region: PAS_8; pfam13188
395491016179	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491016180	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491016181	metal binding site [ion binding]; metal-binding site
395491016182	active site
395491016183	I-site; other site
395491016184	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491016185	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491016186	MarR family; Region: MarR_2; pfam12802
395491016187	5'-3' exonuclease; Region: 53EXOc; smart00475
395491016188	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
395491016189	active site
395491016190	metal binding site 1 [ion binding]; metal-binding site
395491016191	putative 5' ssDNA interaction site; other site
395491016192	metal binding site 3; metal-binding site
395491016193	metal binding site 2 [ion binding]; metal-binding site
395491016194	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
395491016195	putative DNA binding site [nucleotide binding]; other site
395491016196	putative metal binding site [ion binding]; other site
395491016197	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
395491016198	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
395491016199	active site
395491016200	catalytic site [active]
395491016201	substrate binding site [chemical binding]; other site
395491016202	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
395491016203	active site
395491016204	DNA binding site [nucleotide binding]
395491016205	catalytic site [active]
395491016206	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
395491016207	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
395491016208	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
395491016209	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
395491016210	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
395491016211	active site
395491016212	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491016213	Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454
395491016214	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
395491016215	active site
395491016216	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
395491016217	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
395491016218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491016219	dimer interface [polypeptide binding]; other site
395491016220	conserved gate region; other site
395491016221	ABC-ATPase subunit interface; other site
395491016222	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
395491016223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491016224	dimer interface [polypeptide binding]; other site
395491016225	conserved gate region; other site
395491016226	ABC-ATPase subunit interface; other site
395491016227	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
395491016228	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
395491016229	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
395491016230	Walker A/P-loop; other site
395491016231	ATP binding site [chemical binding]; other site
395491016232	Q-loop/lid; other site
395491016233	ABC transporter signature motif; other site
395491016234	Walker B; other site
395491016235	D-loop; other site
395491016236	H-loop/switch region; other site
395491016237	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
395491016238	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
395491016239	trimer interface [polypeptide binding]; other site
395491016240	active site
395491016241	substrate binding site [chemical binding]; other site
395491016242	CoA binding site [chemical binding]; other site
395491016243	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
395491016244	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491016245	Walker A/P-loop; other site
395491016246	ATP binding site [chemical binding]; other site
395491016247	Q-loop/lid; other site
395491016248	ABC transporter signature motif; other site
395491016249	Walker B; other site
395491016250	D-loop; other site
395491016251	H-loop/switch region; other site
395491016252	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
395491016253	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491016254	Walker A/P-loop; other site
395491016255	ATP binding site [chemical binding]; other site
395491016256	Q-loop/lid; other site
395491016257	ABC transporter signature motif; other site
395491016258	Walker B; other site
395491016259	D-loop; other site
395491016260	H-loop/switch region; other site
395491016261	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491016262	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627
395491016263	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626
395491016264	carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147
395491016265	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
395491016266	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
395491016267	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491016268	DNA-binding site [nucleotide binding]; DNA binding site
395491016269	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
395491016270	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395491016271	catalytic core [active]
395491016272	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
395491016273	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
395491016274	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
395491016275	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395491016276	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491016277	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
395491016278	Walker A/P-loop; other site
395491016279	ATP binding site [chemical binding]; other site
395491016280	Q-loop/lid; other site
395491016281	ABC transporter signature motif; other site
395491016282	Walker B; other site
395491016283	D-loop; other site
395491016284	H-loop/switch region; other site
395491016285	glucokinase; Provisional; Region: glk; PRK00292
395491016286	glucokinase, proteobacterial type; Region: glk; TIGR00749
395491016287	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
395491016288	active site
395491016289	dimer interfaces [polypeptide binding]; other site
395491016290	catalytic residues [active]
395491016291	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
395491016292	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
395491016293	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
395491016294	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
395491016295	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
395491016296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491016297	dimer interface [polypeptide binding]; other site
395491016298	conserved gate region; other site
395491016299	putative PBP binding loops; other site
395491016300	ABC-ATPase subunit interface; other site
395491016301	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
395491016302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491016303	dimer interface [polypeptide binding]; other site
395491016304	conserved gate region; other site
395491016305	putative PBP binding loops; other site
395491016306	ABC-ATPase subunit interface; other site
395491016307	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
395491016308	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491016309	Walker A/P-loop; other site
395491016310	ATP binding site [chemical binding]; other site
395491016311	Q-loop/lid; other site
395491016312	ABC transporter signature motif; other site
395491016313	Walker B; other site
395491016314	D-loop; other site
395491016315	H-loop/switch region; other site
395491016316	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
395491016317	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491016318	Walker A/P-loop; other site
395491016319	ATP binding site [chemical binding]; other site
395491016320	Q-loop/lid; other site
395491016321	ABC transporter signature motif; other site
395491016322	Walker B; other site
395491016323	D-loop; other site
395491016324	H-loop/switch region; other site
395491016325	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491016326	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
395491016327	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
395491016328	putative ligand binding site [chemical binding]; other site
395491016329	NAD binding site [chemical binding]; other site
395491016330	dimerization interface [polypeptide binding]; other site
395491016331	catalytic site [active]
395491016332	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
395491016333	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
395491016334	active site
395491016335	KTSC domain; Region: KTSC; pfam13619
395491016336	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
395491016337	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491016338	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491016339	putative DNA binding site [nucleotide binding]; other site
395491016340	dimerization interface [polypeptide binding]; other site
395491016341	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
395491016342	putative Zn2+ binding site [ion binding]; other site
395491016343	AsnC family; Region: AsnC_trans_reg; pfam01037
395491016344	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
395491016345	ligand binding site [chemical binding]; other site
395491016346	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491016347	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
395491016348	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491016349	Walker A/P-loop; other site
395491016350	ATP binding site [chemical binding]; other site
395491016351	Q-loop/lid; other site
395491016352	ABC transporter signature motif; other site
395491016353	Walker B; other site
395491016354	D-loop; other site
395491016355	H-loop/switch region; other site
395491016356	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491016357	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491016358	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
395491016359	TM-ABC transporter signature motif; other site
395491016360	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491016361	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
395491016362	TM-ABC transporter signature motif; other site
395491016363	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
395491016364	active site
395491016365	catalytic motif [active]
395491016366	Zn binding site [ion binding]; other site
395491016367	purine nucleoside phosphorylase; Provisional; Region: PRK08202
395491016368	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
395491016369	intersubunit interface [polypeptide binding]; other site
395491016370	active site
395491016371	catalytic residue [active]
395491016372	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
395491016373	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
395491016374	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
395491016375	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
395491016376	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
395491016377	catalytic motif [active]
395491016378	Catalytic residue [active]
395491016379	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395491016380	active site
395491016381	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
395491016382	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
395491016383	active site
395491016384	purine riboside binding site [chemical binding]; other site
395491016385	phosphopentomutase; Provisional; Region: PRK05362
395491016386	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
395491016387	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
395491016388	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
395491016389	TadE-like protein; Region: TadE; pfam07811
395491016390	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
395491016391	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
395491016392	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
395491016393	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
395491016394	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
395491016395	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
395491016396	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
395491016397	BON domain; Region: BON; pfam04972
395491016398	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
395491016399	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
395491016400	Type IV pili component [Cell motility and secretion]; Region: COG5461
395491016401	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
395491016402	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
395491016403	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
395491016404	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
395491016405	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
395491016406	ATP binding site [chemical binding]; other site
395491016407	Walker A motif; other site
395491016408	hexamer interface [polypeptide binding]; other site
395491016409	Walker B motif; other site
395491016410	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
395491016411	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
395491016412	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
395491016413	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
395491016414	LysE type translocator; Region: LysE; cl00565
395491016415	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
395491016416	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491016417	TPR motif; other site
395491016418	binding surface
395491016419	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
395491016420	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
395491016421	interface (dimer of trimers) [polypeptide binding]; other site
395491016422	Substrate-binding/catalytic site; other site
395491016423	Zn-binding sites [ion binding]; other site
395491016424	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395491016425	MarR family; Region: MarR_2; pfam12802
395491016426	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
395491016427	NlpC/P60 family; Region: NLPC_P60; cl17555
395491016428	amidase; Provisional; Region: PRK07042
395491016429	Amidase; Region: Amidase; cl11426
395491016430	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
395491016431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491016432	dimer interface [polypeptide binding]; other site
395491016433	conserved gate region; other site
395491016434	putative PBP binding loops; other site
395491016435	ABC-ATPase subunit interface; other site
395491016436	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491016437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491016438	dimer interface [polypeptide binding]; other site
395491016439	conserved gate region; other site
395491016440	putative PBP binding loops; other site
395491016441	ABC-ATPase subunit interface; other site
395491016442	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491016443	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
395491016444	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491016445	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491016446	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491016447	dimerization interface [polypeptide binding]; other site
395491016448	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
395491016449	putative active site pocket [active]
395491016450	cleavage site
395491016451	hypothetical protein; Provisional; Region: PRK06149
395491016452	active site
395491016453	substrate binding site [chemical binding]; other site
395491016454	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
395491016455	ATP binding site [chemical binding]; other site
395491016456	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395491016457	inhibitor-cofactor binding pocket; inhibition site
395491016458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491016459	catalytic residue [active]
395491016460	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
395491016461	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
395491016462	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
395491016463	putative active site [active]
395491016464	putative substrate binding site [chemical binding]; other site
395491016465	putative cosubstrate binding site; other site
395491016466	catalytic site [active]
395491016467	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395491016468	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
395491016469	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
395491016470	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
395491016471	Chain length determinant protein; Region: Wzz; cl15801
395491016472	Cephalosporin hydroxylase; Region: CmcI; pfam04989
395491016473	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
395491016474	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
395491016475	inhibitor-cofactor binding pocket; inhibition site
395491016476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491016477	catalytic residue [active]
395491016478	Cephalosporin hydroxylase; Region: CmcI; pfam04989
395491016479	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
395491016480	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
395491016481	trimer interface [polypeptide binding]; other site
395491016482	active site
395491016483	substrate binding site [chemical binding]; other site
395491016484	CoA binding site [chemical binding]; other site
395491016485	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395491016486	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395491016487	active site
395491016488	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
395491016489	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
395491016490	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395491016491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491016492	S-adenosylmethionine binding site [chemical binding]; other site
395491016493	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
395491016494	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
395491016495	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491016496	NAD(P) binding site [chemical binding]; other site
395491016497	active site
395491016498	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
395491016499	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
395491016500	substrate binding site; other site
395491016501	BA14K-like protein; Region: BA14K; pfam07886
395491016502	Rdx family; Region: Rdx; cl01407
395491016503	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
395491016504	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
395491016505	catalytic triad [active]
395491016506	maltose O-acetyltransferase; Provisional; Region: PRK10092
395491016507	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
395491016508	active site
395491016509	substrate binding site [chemical binding]; other site
395491016510	trimer interface [polypeptide binding]; other site
395491016511	CoA binding site [chemical binding]; other site
395491016512	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491016513	CcdB protein; Region: CcdB; cl03380
395491016514	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
395491016515	GTP-binding protein LepA; Provisional; Region: PRK05433
395491016516	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
395491016517	G1 box; other site
395491016518	putative GEF interaction site [polypeptide binding]; other site
395491016519	GTP/Mg2+ binding site [chemical binding]; other site
395491016520	Switch I region; other site
395491016521	G2 box; other site
395491016522	G3 box; other site
395491016523	Switch II region; other site
395491016524	G4 box; other site
395491016525	G5 box; other site
395491016526	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
395491016527	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
395491016528	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
395491016529	Putative transcription activator [Transcription]; Region: TenA; COG0819
395491016530	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491016531	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491016532	non-specific DNA binding site [nucleotide binding]; other site
395491016533	salt bridge; other site
395491016534	sequence-specific DNA binding site [nucleotide binding]; other site
395491016535	Cupin domain; Region: Cupin_2; pfam07883
395491016536	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491016537	Coenzyme A binding pocket [chemical binding]; other site
395491016538	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
395491016539	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491016540	motif II; other site
395491016541	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
395491016542	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
395491016543	active site
395491016544	Zn binding site [ion binding]; other site
395491016545	recombination regulator RecX; Reviewed; Region: recX; PRK00117
395491016546	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
395491016547	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
395491016548	apolar tunnel; other site
395491016549	heme binding site [chemical binding]; other site
395491016550	dimerization interface [polypeptide binding]; other site
395491016551	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
395491016552	diiron binding motif [ion binding]; other site
395491016553	Uncharacterized conserved protein [Function unknown]; Region: COG1633
395491016554	CCC1-related protein family; Region: CCC1_like_1; cd02437
395491016555	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
395491016556	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491016557	Serine hydrolase; Region: Ser_hydrolase; cl17834
395491016558	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
395491016559	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
395491016560	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
395491016561	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
395491016562	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
395491016563	23S rRNA binding site [nucleotide binding]; other site
395491016564	L21 binding site [polypeptide binding]; other site
395491016565	L13 binding site [polypeptide binding]; other site
395491016566	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
395491016567	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
395491016568	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
395491016569	dimer interface [polypeptide binding]; other site
395491016570	motif 1; other site
395491016571	active site
395491016572	motif 2; other site
395491016573	motif 3; other site
395491016574	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
395491016575	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
395491016576	putative tRNA-binding site [nucleotide binding]; other site
395491016577	B3/4 domain; Region: B3_4; pfam03483
395491016578	tRNA synthetase B5 domain; Region: B5; smart00874
395491016579	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
395491016580	dimer interface [polypeptide binding]; other site
395491016581	motif 1; other site
395491016582	motif 3; other site
395491016583	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
395491016584	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
395491016585	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491016586	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491016587	active site
395491016588	catalytic tetrad [active]
395491016589	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491016590	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491016591	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395491016592	putative effector binding pocket; other site
395491016593	putative dimerization interface [polypeptide binding]; other site
395491016594	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
395491016595	dimerization interface [polypeptide binding]; other site
395491016596	metal binding site [ion binding]; metal-binding site
395491016597	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395491016598	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491016599	Coenzyme A binding pocket [chemical binding]; other site
395491016600	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491016601	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491016602	active site
395491016603	catalytic tetrad [active]
395491016604	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491016605	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491016606	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491016607	GtrA-like protein; Region: GtrA; pfam04138
395491016608	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
395491016609	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
395491016610	Ligand binding site; other site
395491016611	Putative Catalytic site; other site
395491016612	DXD motif; other site
395491016613	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
395491016614	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
395491016615	generic binding surface II; other site
395491016616	generic binding surface I; other site
395491016617	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
395491016618	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491016619	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
395491016620	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
395491016621	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491016622	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
395491016623	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
395491016624	N-terminal domain interface [polypeptide binding]; other site
395491016625	dimer interface [polypeptide binding]; other site
395491016626	substrate binding pocket (H-site) [chemical binding]; other site
395491016627	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
395491016628	putative deacylase active site [active]
395491016629	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
395491016630	ArsC family; Region: ArsC; pfam03960
395491016631	putative catalytic residues [active]
395491016632	Predicted deacylase [General function prediction only]; Region: COG3608
395491016633	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
395491016634	active site
395491016635	Zn binding site [ion binding]; other site
395491016636	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
395491016637	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
395491016638	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
395491016639	DNA binding site [nucleotide binding]
395491016640	active site
395491016641	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
395491016642	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491016643	NAD(P) binding site [chemical binding]; other site
395491016644	active site
395491016645	short chain dehydrogenase; Provisional; Region: PRK06180
395491016646	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395491016647	NADP binding site [chemical binding]; other site
395491016648	active site
395491016649	steroid binding site; other site
395491016650	Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512
395491016651	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491016652	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491016653	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395491016654	putative effector binding pocket; other site
395491016655	putative dimerization interface [polypeptide binding]; other site
395491016656	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491016657	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491016658	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
395491016659	substrate binding site [chemical binding]; other site
395491016660	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
395491016661	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491016662	Coenzyme A binding pocket [chemical binding]; other site
395491016663	Helix-turn-helix domain; Region: HTH_18; pfam12833
395491016664	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491016665	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
395491016666	RibD C-terminal domain; Region: RibD_C; cl17279
395491016667	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
395491016668	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491016669	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491016670	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491016671	dimerization interface [polypeptide binding]; other site
395491016672	short chain dehydrogenase; Provisional; Region: PRK06500
395491016673	classical (c) SDRs; Region: SDR_c; cd05233
395491016674	NAD(P) binding site [chemical binding]; other site
395491016675	active site
395491016676	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
395491016677	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
395491016678	GMP synthase; Reviewed; Region: guaA; PRK00074
395491016679	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
395491016680	AMP/PPi binding site [chemical binding]; other site
395491016681	candidate oxyanion hole; other site
395491016682	catalytic triad [active]
395491016683	potential glutamine specificity residues [chemical binding]; other site
395491016684	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
395491016685	ATP Binding subdomain [chemical binding]; other site
395491016686	Ligand Binding sites [chemical binding]; other site
395491016687	Dimerization subdomain; other site
395491016688	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026
395491016689	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705
395491016690	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
395491016691	CoenzymeA binding site [chemical binding]; other site
395491016692	subunit interaction site [polypeptide binding]; other site
395491016693	PHB binding site; other site
395491016694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
395491016695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490
395491016696	Imelysin; Region: Peptidase_M75; cl09159
395491016697	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
395491016698	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
395491016699	Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487
395491016700	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
395491016701	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
395491016702	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
395491016703	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
395491016704	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491016705	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
395491016706	putative NAD(P) binding site [chemical binding]; other site
395491016707	epoxyqueuosine reductase; Region: TIGR00276
395491016708	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
395491016709	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491016710	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
395491016711	C-terminal domain interface [polypeptide binding]; other site
395491016712	GSH binding site (G-site) [chemical binding]; other site
395491016713	dimer interface [polypeptide binding]; other site
395491016714	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395491016715	N-terminal domain interface [polypeptide binding]; other site
395491016716	dimer interface [polypeptide binding]; other site
395491016717	substrate binding pocket (H-site) [chemical binding]; other site
395491016718	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
395491016719	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
395491016720	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
395491016721	putative NAD(P) binding site [chemical binding]; other site
395491016722	active site
395491016723	Uncharacterized conserved protein [Function unknown]; Region: COG5470
395491016724	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
395491016725	active site
395491016726	dimer interface [polypeptide binding]; other site
395491016727	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
395491016728	catalytic core [active]
395491016729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491016730	S-adenosylmethionine binding site [chemical binding]; other site
395491016731	Protein of unknown function DUF72; Region: DUF72; pfam01904
395491016732	DNA polymerase III subunit beta; Validated; Region: PRK05643
395491016733	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
395491016734	putative DNA binding surface [nucleotide binding]; other site
395491016735	dimer interface [polypeptide binding]; other site
395491016736	beta-clamp/clamp loader binding surface; other site
395491016737	beta-clamp/translesion DNA polymerase binding surface; other site
395491016738	Predicted methyltransferases [General function prediction only]; Region: COG0313
395491016739	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
395491016740	putative SAM binding site [chemical binding]; other site
395491016741	putative homodimer interface [polypeptide binding]; other site
395491016742	hypothetical protein; Reviewed; Region: PRK12497
395491016743	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
395491016744	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491016745	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491016746	DNA binding site [nucleotide binding]
395491016747	domain linker motif; other site
395491016748	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491016749	dimerization interface [polypeptide binding]; other site
395491016750	ligand binding site [chemical binding]; other site
395491016751	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491016752	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
395491016753	ligand binding site [chemical binding]; other site
395491016754	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491016755	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491016756	Walker A/P-loop; other site
395491016757	ATP binding site [chemical binding]; other site
395491016758	Q-loop/lid; other site
395491016759	ABC transporter signature motif; other site
395491016760	Walker B; other site
395491016761	D-loop; other site
395491016762	H-loop/switch region; other site
395491016763	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491016764	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491016765	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491016766	TM-ABC transporter signature motif; other site
395491016767	glutathione synthetase; Provisional; Region: PRK05246
395491016768	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
395491016769	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
395491016770	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
395491016771	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
395491016772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491016773	Walker A motif; other site
395491016774	ATP binding site [chemical binding]; other site
395491016775	Walker B motif; other site
395491016776	arginine finger; other site
395491016777	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
395491016778	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
395491016779	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
395491016780	dimer interface [polypeptide binding]; other site
395491016781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491016782	catalytic residue [active]
395491016783	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
395491016784	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
395491016785	Ferritin-like domain; Region: Ferritin; pfam00210
395491016786	dimerization interface [polypeptide binding]; other site
395491016787	DPS ferroxidase diiron center [ion binding]; other site
395491016788	ion pore; other site
395491016789	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
395491016790	EamA-like transporter family; Region: EamA; pfam00892
395491016791	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491016792	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
395491016793	AsnC family; Region: AsnC_trans_reg; pfam01037
395491016794	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395491016795	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
395491016796	trimer interface [polypeptide binding]; other site
395491016797	active site
395491016798	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
395491016799	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
395491016800	G1 box; other site
395491016801	putative GEF interaction site [polypeptide binding]; other site
395491016802	GTP/Mg2+ binding site [chemical binding]; other site
395491016803	Switch I region; other site
395491016804	G2 box; other site
395491016805	G3 box; other site
395491016806	Switch II region; other site
395491016807	G4 box; other site
395491016808	G5 box; other site
395491016809	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
395491016810	LysR family transcriptional regulator; Provisional; Region: PRK14997
395491016811	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491016812	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491016813	putative effector binding pocket; other site
395491016814	dimerization interface [polypeptide binding]; other site
395491016815	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491016816	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
395491016817	C-terminal domain interface [polypeptide binding]; other site
395491016818	GSH binding site (G-site) [chemical binding]; other site
395491016819	dimer interface [polypeptide binding]; other site
395491016820	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395491016821	N-terminal domain interface [polypeptide binding]; other site
395491016822	dimer interface [polypeptide binding]; other site
395491016823	substrate binding pocket (H-site) [chemical binding]; other site
395491016824	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
395491016825	homotrimer interaction site [polypeptide binding]; other site
395491016826	putative active site [active]
395491016827	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491016828	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491016829	putative DNA binding site [nucleotide binding]; other site
395491016830	putative Zn2+ binding site [ion binding]; other site
395491016831	AsnC family; Region: AsnC_trans_reg; pfam01037
395491016832	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
395491016833	homodimer interaction site [polypeptide binding]; other site
395491016834	cofactor binding site; other site
395491016835	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491016836	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
395491016837	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
395491016838	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
395491016839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491016840	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491016841	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491016842	DNA-binding site [nucleotide binding]; DNA binding site
395491016843	FCD domain; Region: FCD; pfam07729
395491016844	Pirin-related protein [General function prediction only]; Region: COG1741
395491016845	Pirin; Region: Pirin; pfam02678
395491016846	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
395491016847	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
395491016848	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
395491016849	putative active site [active]
395491016850	putative dimer interface [polypeptide binding]; other site
395491016851	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
395491016852	Flavoprotein; Region: Flavoprotein; pfam02441
395491016853	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
395491016854	short chain dehydrogenase; Provisional; Region: PRK06500
395491016855	classical (c) SDRs; Region: SDR_c; cd05233
395491016856	NAD(P) binding site [chemical binding]; other site
395491016857	active site
395491016858	short chain dehydrogenase; Provisional; Region: PRK07478
395491016859	classical (c) SDRs; Region: SDR_c; cd05233
395491016860	NAD(P) binding site [chemical binding]; other site
395491016861	active site
395491016862	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491016863	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491016864	putative effector binding pocket; other site
395491016865	dimerization interface [polypeptide binding]; other site
395491016866	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
395491016867	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491016868	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
395491016869	putative dimerization interface [polypeptide binding]; other site
395491016870	putative substrate binding pocket [chemical binding]; other site
395491016871	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491016872	putative substrate translocation pore; other site
395491016873	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491016874	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
395491016875	urocanate hydratase; Provisional; Region: PRK05414
395491016876	Protein of unknown function (DUF917); Region: DUF917; pfam06032
395491016877	allantoate amidohydrolase; Reviewed; Region: PRK12893
395491016878	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
395491016879	active site
395491016880	metal binding site [ion binding]; metal-binding site
395491016881	dimer interface [polypeptide binding]; other site
395491016882	allantoinase; Region: allantoinase; TIGR03178
395491016883	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491016884	active site
395491016885	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
395491016886	active sites [active]
395491016887	tetramer interface [polypeptide binding]; other site
395491016888	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
395491016889	ABC1 family; Region: ABC1; pfam03109
395491016890	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
395491016891	active site
395491016892	ATP binding site [chemical binding]; other site
395491016893	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
395491016894	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491016895	S-adenosylmethionine binding site [chemical binding]; other site
395491016896	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
395491016897	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
395491016898	DNA binding site [nucleotide binding]
395491016899	catalytic residue [active]
395491016900	H2TH interface [polypeptide binding]; other site
395491016901	putative catalytic residues [active]
395491016902	turnover-facilitating residue; other site
395491016903	intercalation triad [nucleotide binding]; other site
395491016904	8OG recognition residue [nucleotide binding]; other site
395491016905	putative reading head residues; other site
395491016906	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
395491016907	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
395491016908	enoyl-CoA hydratase; Provisional; Region: PRK05862
395491016909	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395491016910	substrate binding site [chemical binding]; other site
395491016911	oxyanion hole (OAH) forming residues; other site
395491016912	trimer interface [polypeptide binding]; other site
395491016913	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
395491016914	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
395491016915	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491016916	putative ligand binding site [chemical binding]; other site
395491016917	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491016918	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491016919	Walker A/P-loop; other site
395491016920	ATP binding site [chemical binding]; other site
395491016921	Q-loop/lid; other site
395491016922	ABC transporter signature motif; other site
395491016923	Walker B; other site
395491016924	D-loop; other site
395491016925	H-loop/switch region; other site
395491016926	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491016927	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491016928	TM-ABC transporter signature motif; other site
395491016929	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491016930	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491016931	TM-ABC transporter signature motif; other site
395491016932	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
395491016933	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
395491016934	N- and C-terminal domain interface [polypeptide binding]; other site
395491016935	active site
395491016936	MgATP binding site [chemical binding]; other site
395491016937	catalytic site [active]
395491016938	metal binding site [ion binding]; metal-binding site
395491016939	glycerol binding site [chemical binding]; other site
395491016940	homotetramer interface [polypeptide binding]; other site
395491016941	homodimer interface [polypeptide binding]; other site
395491016942	FBP binding site [chemical binding]; other site
395491016943	protein IIAGlc interface [polypeptide binding]; other site
395491016944	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491016945	Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294
395491016946	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491016947	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491016948	dimer interface [polypeptide binding]; other site
395491016949	conserved gate region; other site
395491016950	putative PBP binding loops; other site
395491016951	ABC-ATPase subunit interface; other site
395491016952	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491016953	dimer interface [polypeptide binding]; other site
395491016954	conserved gate region; other site
395491016955	putative PBP binding loops; other site
395491016956	ABC-ATPase subunit interface; other site
395491016957	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491016958	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
395491016959	Walker A/P-loop; other site
395491016960	ATP binding site [chemical binding]; other site
395491016961	Q-loop/lid; other site
395491016962	ABC transporter signature motif; other site
395491016963	Walker B; other site
395491016964	D-loop; other site
395491016965	H-loop/switch region; other site
395491016966	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491016967	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
395491016968	Walker A/P-loop; other site
395491016969	ATP binding site [chemical binding]; other site
395491016970	Q-loop/lid; other site
395491016971	ABC transporter signature motif; other site
395491016972	Walker B; other site
395491016973	D-loop; other site
395491016974	H-loop/switch region; other site
395491016975	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
395491016976	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
395491016977	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
395491016978	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
395491016979	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
395491016980	EamA-like transporter family; Region: EamA; pfam00892
395491016981	EamA-like transporter family; Region: EamA; pfam00892
395491016982	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491016983	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491016984	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491016985	dimerization interface [polypeptide binding]; other site
395491016986	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
395491016987	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491016988	Coenzyme A binding pocket [chemical binding]; other site
395491016989	Protein of unknown function (DUF992); Region: DUF992; pfam06186
395491016990	murein hydrolase B; Provisional; Region: PRK10760; cl17906
395491016991	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
395491016992	Ca2+ binding site [ion binding]; other site
395491016993	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491016994	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395491016995	active site
395491016996	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
395491016997	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395491016998	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491016999	Walker A/P-loop; other site
395491017000	ATP binding site [chemical binding]; other site
395491017001	Q-loop/lid; other site
395491017002	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395491017003	ABC transporter signature motif; other site
395491017004	Walker B; other site
395491017005	D-loop; other site
395491017006	ABC transporter; Region: ABC_tran_2; pfam12848
395491017007	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395491017008	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
395491017009	active site
395491017010	catalytic residues [active]
395491017011	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
395491017012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491017013	putative substrate translocation pore; other site
395491017014	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
395491017015	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491017016	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491017017	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491017018	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491017019	mannonate dehydratase; Provisional; Region: PRK03906
395491017020	mannonate dehydratase; Region: uxuA; TIGR00695
395491017021	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491017022	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491017023	DNA-binding site [nucleotide binding]; DNA binding site
395491017024	FCD domain; Region: FCD; pfam07729
395491017025	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
395491017026	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
395491017027	O-Antigen ligase; Region: Wzy_C; pfam04932
395491017028	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
395491017029	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395491017030	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
395491017031	NAD(P) binding site [chemical binding]; other site
395491017032	homodimer interface [polypeptide binding]; other site
395491017033	substrate binding site [chemical binding]; other site
395491017034	active site
395491017035	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395491017036	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
395491017037	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395491017038	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
395491017039	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491017040	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491017041	TM-ABC transporter signature motif; other site
395491017042	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491017043	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491017044	Walker A/P-loop; other site
395491017045	ATP binding site [chemical binding]; other site
395491017046	Q-loop/lid; other site
395491017047	ABC transporter signature motif; other site
395491017048	Walker B; other site
395491017049	D-loop; other site
395491017050	H-loop/switch region; other site
395491017051	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491017052	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491017053	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491017054	TM-ABC transporter signature motif; other site
395491017055	MarR family; Region: MarR_2; pfam12802
395491017056	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491017057	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
395491017058	nucleotide binding site [chemical binding]; other site
395491017059	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
395491017060	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395491017061	HSP70 interaction site [polypeptide binding]; other site
395491017062	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
395491017063	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
395491017064	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
395491017065	FtsX-like permease family; Region: FtsX; pfam02687
395491017066	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
395491017067	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395491017068	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395491017069	Walker A/P-loop; other site
395491017070	ATP binding site [chemical binding]; other site
395491017071	Q-loop/lid; other site
395491017072	ABC transporter signature motif; other site
395491017073	Walker B; other site
395491017074	D-loop; other site
395491017075	H-loop/switch region; other site
395491017076	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
395491017077	dimer interface [polypeptide binding]; other site
395491017078	heat shock protein 90; Provisional; Region: PRK05218
395491017079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491017080	ATP binding site [chemical binding]; other site
395491017081	Mg2+ binding site [ion binding]; other site
395491017082	G-X-G motif; other site
395491017083	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
395491017084	Ligand binding site; other site
395491017085	metal-binding site
395491017086	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
395491017087	XdhC Rossmann domain; Region: XdhC_C; pfam13478
395491017088	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
395491017089	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
395491017090	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
395491017091	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
395491017092	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
395491017093	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491017094	MarR family; Region: MarR_2; pfam12802
395491017095	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
395491017096	catalytic triad [active]
395491017097	conserved cis-peptide bond; other site
395491017098	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395491017099	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491017100	Walker A/P-loop; other site
395491017101	ATP binding site [chemical binding]; other site
395491017102	Q-loop/lid; other site
395491017103	ABC transporter signature motif; other site
395491017104	Walker B; other site
395491017105	D-loop; other site
395491017106	H-loop/switch region; other site
395491017107	TOBE domain; Region: TOBE_2; pfam08402
395491017108	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491017109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017110	dimer interface [polypeptide binding]; other site
395491017111	conserved gate region; other site
395491017112	putative PBP binding loops; other site
395491017113	ABC-ATPase subunit interface; other site
395491017114	ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176
395491017115	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491017116	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
395491017117	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395491017118	Trehalase; Region: Trehalase; cl17346
395491017119	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395491017120	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
395491017121	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
395491017122	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395491017123	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395491017124	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395491017125	Cytochrome c; Region: Cytochrom_C; pfam00034
395491017126	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395491017127	Cytochrome c; Region: Cytochrom_C; cl11414
395491017128	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
395491017129	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
395491017130	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
395491017131	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491017132	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491017133	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
395491017134	Isochorismatase family; Region: Isochorismatase; pfam00857
395491017135	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
395491017136	catalytic triad [active]
395491017137	conserved cis-peptide bond; other site
395491017138	MarR family; Region: MarR_2; cl17246
395491017139	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491017140	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491017141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491017142	putative substrate translocation pore; other site
395491017143	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
395491017144	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
395491017145	replication initiation protein RepC; Provisional; Region: PRK13824
395491017146	Replication protein C N-terminal domain; Region: RP-C; pfam03428
395491017147	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
395491017148	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
395491017149	ParB-like nuclease domain; Region: ParBc; pfam02195
395491017150	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
395491017151	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
395491017152	DNA binding residues [nucleotide binding]
395491017153	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491017154	P-loop; other site
395491017155	Magnesium ion binding site [ion binding]; other site
395491017156	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491017157	Magnesium ion binding site [ion binding]; other site
395491017158	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
395491017159	PAS fold; Region: PAS_7; pfam12860
395491017160	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491017161	dimer interface [polypeptide binding]; other site
395491017162	phosphorylation site [posttranslational modification]
395491017163	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491017164	ATP binding site [chemical binding]; other site
395491017165	Mg2+ binding site [ion binding]; other site
395491017166	G-X-G motif; other site
395491017167	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491017168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491017169	active site
395491017170	phosphorylation site [posttranslational modification]
395491017171	intermolecular recognition site; other site
395491017172	dimerization interface [polypeptide binding]; other site
395491017173	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491017174	DNA binding site [nucleotide binding]
395491017175	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395491017176	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395491017177	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
395491017178	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395491017179	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
395491017180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017181	dimer interface [polypeptide binding]; other site
395491017182	conserved gate region; other site
395491017183	putative PBP binding loops; other site
395491017184	ABC-ATPase subunit interface; other site
395491017185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017186	dimer interface [polypeptide binding]; other site
395491017187	conserved gate region; other site
395491017188	putative PBP binding loops; other site
395491017189	ABC-ATPase subunit interface; other site
395491017190	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395491017191	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491017192	Walker A/P-loop; other site
395491017193	ATP binding site [chemical binding]; other site
395491017194	Q-loop/lid; other site
395491017195	ABC transporter signature motif; other site
395491017196	Walker B; other site
395491017197	D-loop; other site
395491017198	H-loop/switch region; other site
395491017199	TOBE domain; Region: TOBE_2; pfam08402
395491017200	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
395491017201	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491017202	motif II; other site
395491017203	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491017204	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491017205	DNA binding site [nucleotide binding]
395491017206	domain linker motif; other site
395491017207	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
395491017208	putative dimerization interface [polypeptide binding]; other site
395491017209	putative ligand binding site [chemical binding]; other site
395491017210	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
395491017211	nudix motif; other site
395491017212	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
395491017213	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
395491017214	dimer interface [polypeptide binding]; other site
395491017215	ADP-ribose binding site [chemical binding]; other site
395491017216	active site
395491017217	nudix motif; other site
395491017218	metal binding site [ion binding]; metal-binding site
395491017219	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
395491017220	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
395491017221	phosphate binding site [ion binding]; other site
395491017222	putative substrate binding pocket [chemical binding]; other site
395491017223	dimer interface [polypeptide binding]; other site
395491017224	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395491017225	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395491017226	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
395491017227	active site
395491017228	dimerization interface [polypeptide binding]; other site
395491017229	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
395491017230	active site
395491017231	catalytic residues [active]
395491017232	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
395491017233	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395491017234	HSP70 interaction site [polypeptide binding]; other site
395491017235	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491017236	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
395491017237	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395491017238	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
395491017239	active site
395491017240	DNA polymerase IV; Validated; Region: PRK02406
395491017241	DNA binding site [nucleotide binding]
395491017242	Uncharacterized conserved protein [Function unknown]; Region: COG4544
395491017243	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
395491017244	putative dimer interface [polypeptide binding]; other site
395491017245	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491017246	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
395491017247	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
395491017248	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
395491017249	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
395491017250	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491017251	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491017252	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491017253	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
395491017254	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491017255	ligand binding site [chemical binding]; other site
395491017256	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491017257	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491017258	Walker A/P-loop; other site
395491017259	ATP binding site [chemical binding]; other site
395491017260	Q-loop/lid; other site
395491017261	ABC transporter signature motif; other site
395491017262	Walker B; other site
395491017263	D-loop; other site
395491017264	H-loop/switch region; other site
395491017265	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491017266	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491017267	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491017268	TM-ABC transporter signature motif; other site
395491017269	L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160
395491017270	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
395491017271	hexamer (dimer of trimers) interface [polypeptide binding]; other site
395491017272	substrate binding site [chemical binding]; other site
395491017273	trimer interface [polypeptide binding]; other site
395491017274	Mn binding site [ion binding]; other site
395491017275	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491017276	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491017277	non-specific DNA binding site [nucleotide binding]; other site
395491017278	salt bridge; other site
395491017279	sequence-specific DNA binding site [nucleotide binding]; other site
395491017280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491017281	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491017282	putative substrate translocation pore; other site
395491017283	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
395491017284	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491017285	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
395491017286	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
395491017287	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
395491017288	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
395491017289	Walker A/P-loop; other site
395491017290	ATP binding site [chemical binding]; other site
395491017291	Q-loop/lid; other site
395491017292	ABC transporter signature motif; other site
395491017293	Walker B; other site
395491017294	D-loop; other site
395491017295	H-loop/switch region; other site
395491017296	NIL domain; Region: NIL; pfam09383
395491017297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017298	dimer interface [polypeptide binding]; other site
395491017299	conserved gate region; other site
395491017300	ABC-ATPase subunit interface; other site
395491017301	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395491017302	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395491017303	active site
395491017304	non-prolyl cis peptide bond; other site
395491017305	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
395491017306	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
395491017307	active site
395491017308	substrate binding site [chemical binding]; other site
395491017309	coenzyme B12 binding site [chemical binding]; other site
395491017310	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
395491017311	B12 binding site [chemical binding]; other site
395491017312	cobalt ligand [ion binding]; other site
395491017313	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
395491017314	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
395491017315	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491017316	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491017317	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491017318	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491017319	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395491017320	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491017321	active site
395491017322	metal binding site [ion binding]; metal-binding site
395491017323	allophanate hydrolase; Provisional; Region: PRK08186
395491017324	Amidase; Region: Amidase; pfam01425
395491017325	urea carboxylase; Region: urea_carbox; TIGR02712
395491017326	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395491017327	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395491017328	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
395491017329	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
395491017330	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
395491017331	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395491017332	carboxyltransferase (CT) interaction site; other site
395491017333	biotinylation site [posttranslational modification]; other site
395491017334	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
395491017335	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
395491017336	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
395491017337	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
395491017338	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395491017339	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395491017340	Walker A/P-loop; other site
395491017341	ATP binding site [chemical binding]; other site
395491017342	Q-loop/lid; other site
395491017343	ABC transporter signature motif; other site
395491017344	Walker B; other site
395491017345	D-loop; other site
395491017346	H-loop/switch region; other site
395491017347	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491017348	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395491017349	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
395491017350	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395491017351	Cupin domain; Region: Cupin_2; pfam07883
395491017352	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395491017353	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491017354	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491017355	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491017356	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017357	dimer interface [polypeptide binding]; other site
395491017358	conserved gate region; other site
395491017359	putative PBP binding loops; other site
395491017360	ABC-ATPase subunit interface; other site
395491017361	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491017362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017363	dimer interface [polypeptide binding]; other site
395491017364	conserved gate region; other site
395491017365	putative PBP binding loops; other site
395491017366	ABC-ATPase subunit interface; other site
395491017367	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491017368	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491017369	Walker A/P-loop; other site
395491017370	ATP binding site [chemical binding]; other site
395491017371	Q-loop/lid; other site
395491017372	ABC transporter signature motif; other site
395491017373	Walker B; other site
395491017374	D-loop; other site
395491017375	H-loop/switch region; other site
395491017376	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491017377	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491017378	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491017379	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491017380	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491017381	active site
395491017382	catalytic tetrad [active]
395491017383	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
395491017384	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
395491017385	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
395491017386	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
395491017387	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
395491017388	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
395491017389	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491017390	Walker A/P-loop; other site
395491017391	ATP binding site [chemical binding]; other site
395491017392	Q-loop/lid; other site
395491017393	ABC transporter signature motif; other site
395491017394	Walker B; other site
395491017395	D-loop; other site
395491017396	H-loop/switch region; other site
395491017397	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
395491017398	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491017399	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
395491017400	Walker A/P-loop; other site
395491017401	ATP binding site [chemical binding]; other site
395491017402	Q-loop/lid; other site
395491017403	ABC transporter signature motif; other site
395491017404	Walker B; other site
395491017405	D-loop; other site
395491017406	H-loop/switch region; other site
395491017407	Predicted transcriptional regulators [Transcription]; Region: COG1510
395491017408	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491017409	dimerization interface [polypeptide binding]; other site
395491017410	putative DNA binding site [nucleotide binding]; other site
395491017411	putative Zn2+ binding site [ion binding]; other site
395491017412	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
395491017413	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
395491017414	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
395491017415	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
395491017416	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
395491017417	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
395491017418	putative ligand binding site [chemical binding]; other site
395491017419	putative NAD binding site [chemical binding]; other site
395491017420	catalytic site [active]
395491017421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
395491017422	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
395491017423	putative deacylase active site [active]
395491017424	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395491017425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017426	dimer interface [polypeptide binding]; other site
395491017427	conserved gate region; other site
395491017428	putative PBP binding loops; other site
395491017429	ABC-ATPase subunit interface; other site
395491017430	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491017431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017432	dimer interface [polypeptide binding]; other site
395491017433	conserved gate region; other site
395491017434	putative PBP binding loops; other site
395491017435	ABC-ATPase subunit interface; other site
395491017436	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395491017437	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491017438	Walker A/P-loop; other site
395491017439	ATP binding site [chemical binding]; other site
395491017440	Q-loop/lid; other site
395491017441	ABC transporter signature motif; other site
395491017442	Walker B; other site
395491017443	D-loop; other site
395491017444	H-loop/switch region; other site
395491017445	TOBE domain; Region: TOBE_2; pfam08402
395491017446	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
395491017447	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
395491017448	active site
395491017449	catalytic site [active]
395491017450	metal binding site [ion binding]; metal-binding site
395491017451	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491017452	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491017453	domain linker motif; other site
395491017454	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
395491017455	putative dimerization interface [polypeptide binding]; other site
395491017456	putative ligand binding site [chemical binding]; other site
395491017457	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
395491017458	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395491017459	active site
395491017460	dimerization interface [polypeptide binding]; other site
395491017461	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395491017462	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491017463	binding surface
395491017464	TPR motif; other site
395491017465	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395491017466	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491017467	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491017468	metal binding site [ion binding]; metal-binding site
395491017469	active site
395491017470	I-site; other site
395491017471	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
395491017472	active site
395491017473	catalytic site [active]
395491017474	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
395491017475	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395491017476	catalytic residue [active]
395491017477	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491017478	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491017479	Walker A/P-loop; other site
395491017480	ATP binding site [chemical binding]; other site
395491017481	Q-loop/lid; other site
395491017482	ABC transporter signature motif; other site
395491017483	Walker B; other site
395491017484	D-loop; other site
395491017485	H-loop/switch region; other site
395491017486	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491017487	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491017488	Walker A/P-loop; other site
395491017489	ATP binding site [chemical binding]; other site
395491017490	Q-loop/lid; other site
395491017491	ABC transporter signature motif; other site
395491017492	Walker B; other site
395491017493	D-loop; other site
395491017494	H-loop/switch region; other site
395491017495	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491017496	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491017497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017498	dimer interface [polypeptide binding]; other site
395491017499	conserved gate region; other site
395491017500	putative PBP binding loops; other site
395491017501	ABC-ATPase subunit interface; other site
395491017502	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491017503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017504	dimer interface [polypeptide binding]; other site
395491017505	conserved gate region; other site
395491017506	putative PBP binding loops; other site
395491017507	ABC-ATPase subunit interface; other site
395491017508	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491017509	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
395491017510	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395491017511	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395491017512	active site
395491017513	non-prolyl cis peptide bond; other site
395491017514	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491017515	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491017516	TM-ABC transporter signature motif; other site
395491017517	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491017518	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491017519	Walker A/P-loop; other site
395491017520	ATP binding site [chemical binding]; other site
395491017521	Q-loop/lid; other site
395491017522	ABC transporter signature motif; other site
395491017523	Walker B; other site
395491017524	D-loop; other site
395491017525	H-loop/switch region; other site
395491017526	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491017527	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
395491017528	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491017529	putative ligand binding site [chemical binding]; other site
395491017530	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395491017531	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
395491017532	active site
395491017533	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
395491017534	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
395491017535	Flavin binding site [chemical binding]; other site
395491017536	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395491017537	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395491017538	active site
395491017539	non-prolyl cis peptide bond; other site
395491017540	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491017541	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491017542	DNA binding site [nucleotide binding]
395491017543	domain linker motif; other site
395491017544	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
395491017545	ligand binding site [chemical binding]; other site
395491017546	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491017547	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491017548	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491017549	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491017550	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491017551	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491017552	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491017553	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017554	dimer interface [polypeptide binding]; other site
395491017555	conserved gate region; other site
395491017556	putative PBP binding loops; other site
395491017557	ABC-ATPase subunit interface; other site
395491017558	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491017559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017560	dimer interface [polypeptide binding]; other site
395491017561	conserved gate region; other site
395491017562	ABC-ATPase subunit interface; other site
395491017563	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491017564	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491017565	Walker A/P-loop; other site
395491017566	ATP binding site [chemical binding]; other site
395491017567	Q-loop/lid; other site
395491017568	ABC transporter signature motif; other site
395491017569	Walker B; other site
395491017570	D-loop; other site
395491017571	H-loop/switch region; other site
395491017572	TOBE domain; Region: TOBE_2; pfam08402
395491017573	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491017574	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491017575	DNA binding site [nucleotide binding]
395491017576	domain linker motif; other site
395491017577	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293
395491017578	putative dimerization interface [polypeptide binding]; other site
395491017579	putative ligand binding site [chemical binding]; other site
395491017580	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491017581	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
395491017582	ligand binding site [chemical binding]; other site
395491017583	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395491017584	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491017585	Walker A/P-loop; other site
395491017586	ATP binding site [chemical binding]; other site
395491017587	Q-loop/lid; other site
395491017588	ABC transporter signature motif; other site
395491017589	Walker B; other site
395491017590	D-loop; other site
395491017591	H-loop/switch region; other site
395491017592	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491017593	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491017594	TM-ABC transporter signature motif; other site
395491017595	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
395491017596	active site
395491017597	substrate binding pocket [chemical binding]; other site
395491017598	homodimer interaction site [polypeptide binding]; other site
395491017599	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
395491017600	Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434
395491017601	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
395491017602	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
395491017603	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395491017604	substrate binding site [chemical binding]; other site
395491017605	dimer interface [polypeptide binding]; other site
395491017606	ATP binding site [chemical binding]; other site
395491017607	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395491017608	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
395491017609	active site
395491017610	dimerization interface [polypeptide binding]; other site
395491017611	TOBE domain; Region: TOBE_2; pfam08402
395491017612	methionine sulfoxide reductase A; Provisional; Region: PRK14054
395491017613	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491017614	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491017615	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
395491017616	putative dimerization interface [polypeptide binding]; other site
395491017617	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491017618	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
395491017619	putative NAD(P) binding site [chemical binding]; other site
395491017620	putative active site [active]
395491017621	hypothetical protein; Validated; Region: PRK08245
395491017622	protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944
395491017623	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491017624	S-adenosylmethionine binding site [chemical binding]; other site
395491017625	cytosine deaminase; Validated; Region: PRK07572
395491017626	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
395491017627	active site
395491017628	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491017629	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
395491017630	TM-ABC transporter signature motif; other site
395491017631	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491017632	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
395491017633	TM-ABC transporter signature motif; other site
395491017634	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
395491017635	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491017636	Walker A/P-loop; other site
395491017637	ATP binding site [chemical binding]; other site
395491017638	Q-loop/lid; other site
395491017639	ABC transporter signature motif; other site
395491017640	Walker B; other site
395491017641	D-loop; other site
395491017642	H-loop/switch region; other site
395491017643	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491017644	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
395491017645	Amidase; Region: Amidase; cl11426
395491017646	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
395491017647	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
395491017648	putative ligand binding site [chemical binding]; other site
395491017649	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
395491017650	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395491017651	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395491017652	putative acyl-acceptor binding pocket; other site
395491017653	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
395491017654	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
395491017655	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
395491017656	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
395491017657	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
395491017658	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395491017659	HSP70 interaction site [polypeptide binding]; other site
395491017660	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
395491017661	substrate binding site [polypeptide binding]; other site
395491017662	dimer interface [polypeptide binding]; other site
395491017663	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395491017664	Ligand Binding Site [chemical binding]; other site
395491017665	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
395491017666	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
395491017667	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
395491017668	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
395491017669	putative S-transferase; Provisional; Region: PRK11752
395491017670	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
395491017671	C-terminal domain interface [polypeptide binding]; other site
395491017672	GSH binding site (G-site) [chemical binding]; other site
395491017673	dimer interface [polypeptide binding]; other site
395491017674	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
395491017675	dimer interface [polypeptide binding]; other site
395491017676	N-terminal domain interface [polypeptide binding]; other site
395491017677	active site
395491017678	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491017679	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
395491017680	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395491017681	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491017682	Walker A/P-loop; other site
395491017683	ATP binding site [chemical binding]; other site
395491017684	Q-loop/lid; other site
395491017685	ABC transporter signature motif; other site
395491017686	Walker B; other site
395491017687	D-loop; other site
395491017688	H-loop/switch region; other site
395491017689	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491017690	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491017691	Walker A/P-loop; other site
395491017692	ATP binding site [chemical binding]; other site
395491017693	Q-loop/lid; other site
395491017694	ABC transporter signature motif; other site
395491017695	Walker B; other site
395491017696	D-loop; other site
395491017697	H-loop/switch region; other site
395491017698	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491017699	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
395491017700	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017701	dimer interface [polypeptide binding]; other site
395491017702	conserved gate region; other site
395491017703	putative PBP binding loops; other site
395491017704	ABC-ATPase subunit interface; other site
395491017705	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491017706	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017707	dimer interface [polypeptide binding]; other site
395491017708	conserved gate region; other site
395491017709	putative PBP binding loops; other site
395491017710	ABC-ATPase subunit interface; other site
395491017711	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
395491017712	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395491017713	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491017714	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491017715	DNA binding residues [nucleotide binding]
395491017716	dimerization interface [polypeptide binding]; other site
395491017717	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
395491017718	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395491017719	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491017720	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
395491017721	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491017722	NAD(P) binding site [chemical binding]; other site
395491017723	active site
395491017724	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
395491017725	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
395491017726	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491017727	NAD(P) binding site [chemical binding]; other site
395491017728	active site
395491017729	acetoacetate decarboxylase; Provisional; Region: PRK02265
395491017730	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395491017731	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395491017732	Patatin phospholipase; Region: DUF3734; pfam12536
395491017733	Helix-turn-helix domain; Region: HTH_28; pfam13518
395491017734	Winged helix-turn helix; Region: HTH_29; pfam13551
395491017735	Homeodomain-like domain; Region: HTH_32; pfam13565
395491017736	Integrase core domain; Region: rve; pfam00665
395491017737	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491017738	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491017739	TM-ABC transporter signature motif; other site
395491017740	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
395491017741	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491017742	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491017743	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
395491017744	putative active site [active]
395491017745	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
395491017746	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491017747	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491017748	Walker A/P-loop; other site
395491017749	ATP binding site [chemical binding]; other site
395491017750	Q-loop/lid; other site
395491017751	ABC transporter signature motif; other site
395491017752	Walker B; other site
395491017753	D-loop; other site
395491017754	H-loop/switch region; other site
395491017755	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395491017756	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
395491017757	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
395491017758	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
395491017759	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
395491017760	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
395491017761	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
395491017762	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
395491017763	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395491017764	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
395491017765	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
395491017766	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
395491017767	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
395491017768	VCBS repeat; Region: VCBS_repeat; TIGR01965
395491017769	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
395491017770	Cadherin repeat-like domain; Region: CA_like; cl15786
395491017771	Ca2+ binding site [ion binding]; other site
395491017772	VCBS repeat; Region: VCBS_repeat; TIGR01965
395491017773	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
395491017774	Cadherin repeat-like domain; Region: CA_like; cl15786
395491017775	Ca2+ binding site [ion binding]; other site
395491017776	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
395491017777	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
395491017778	SLBB domain; Region: SLBB; pfam10531
395491017779	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
395491017780	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
395491017781	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
395491017782	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
395491017783	inhibitor-cofactor binding pocket; inhibition site
395491017784	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491017785	catalytic residue [active]
395491017786	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491017787	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491017788	NAD(P) binding site [chemical binding]; other site
395491017789	active site
395491017790	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395491017791	putative trimer interface [polypeptide binding]; other site
395491017792	putative CoA binding site [chemical binding]; other site
395491017793	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
395491017794	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
395491017795	inhibitor-cofactor binding pocket; inhibition site
395491017796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491017797	catalytic residue [active]
395491017798	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491017799	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491017800	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491017801	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
395491017802	putative trimer interface [polypeptide binding]; other site
395491017803	putative active site [active]
395491017804	putative substrate binding site [chemical binding]; other site
395491017805	putative CoA binding site [chemical binding]; other site
395491017806	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491017807	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491017808	DNA binding residues [nucleotide binding]
395491017809	dimerization interface [polypeptide binding]; other site
395491017810	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
395491017811	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491017812	binding surface
395491017813	TPR repeat; Region: TPR_11; pfam13414
395491017814	TPR motif; other site
395491017815	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
395491017816	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491017817	NAD binding site [chemical binding]; other site
395491017818	putative substrate binding site 2 [chemical binding]; other site
395491017819	putative substrate binding site 1 [chemical binding]; other site
395491017820	active site
395491017821	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
395491017822	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395491017823	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
395491017824	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
395491017825	Right handed beta helix region; Region: Beta_helix; pfam13229
395491017826	Right handed beta helix region; Region: Beta_helix; pfam13229
395491017827	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
395491017828	O-Antigen ligase; Region: Wzy_C; pfam04932
395491017829	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395491017830	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
395491017831	active site
395491017832	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491017833	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
395491017834	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491017835	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395491017836	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
395491017837	AAA domain; Region: AAA_31; pfam13614
395491017838	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395491017839	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
395491017840	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
395491017841	NADP-binding site; other site
395491017842	homotetramer interface [polypeptide binding]; other site
395491017843	substrate binding site [chemical binding]; other site
395491017844	homodimer interface [polypeptide binding]; other site
395491017845	active site
395491017846	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
395491017847	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
395491017848	NADP binding site [chemical binding]; other site
395491017849	active site
395491017850	putative substrate binding site [chemical binding]; other site
395491017851	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
395491017852	MobA/MobL family; Region: MobA_MobL; pfam03389
395491017853	AAA domain; Region: AAA_30; pfam13604
395491017854	Family description; Region: UvrD_C_2; pfam13538
395491017855	Domain of unknown function (DUF303); Region: DUF303; pfam03629
395491017856	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491017857	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491017858	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
395491017859	dimerization interface [polypeptide binding]; other site
395491017860	substrate binding pocket [chemical binding]; other site
395491017861	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
395491017862	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395491017863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491017864	S-adenosylmethionine binding site [chemical binding]; other site
395491017865	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
395491017866	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
395491017867	catalytic site [active]
395491017868	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491017869	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491017870	DNA binding residues [nucleotide binding]
395491017871	dimerization interface [polypeptide binding]; other site
395491017872	choline dehydrogenase; Validated; Region: PRK02106
395491017873	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395491017874	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395491017875	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
395491017876	active site
395491017877	catalytic residues [active]
395491017878	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491017879	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491017880	TM-ABC transporter signature motif; other site
395491017881	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491017882	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491017883	Walker A/P-loop; other site
395491017884	ATP binding site [chemical binding]; other site
395491017885	Q-loop/lid; other site
395491017886	ABC transporter signature motif; other site
395491017887	Walker B; other site
395491017888	D-loop; other site
395491017889	H-loop/switch region; other site
395491017890	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491017891	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491017892	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
395491017893	ligand binding site [chemical binding]; other site
395491017894	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491017895	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491017896	DNA-binding site [nucleotide binding]; DNA binding site
395491017897	FCD domain; Region: FCD; pfam07729
395491017898	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395491017899	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491017900	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
395491017901	FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315
395491017902	N- and C-terminal domain interface [polypeptide binding]; other site
395491017903	active site
395491017904	MgATP binding site [chemical binding]; other site
395491017905	catalytic site [active]
395491017906	metal binding site [ion binding]; metal-binding site
395491017907	carbohydrate binding site [chemical binding]; other site
395491017908	putative homodimer interface [polypeptide binding]; other site
395491017909	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
395491017910	classical (c) SDRs; Region: SDR_c; cd05233
395491017911	NAD(P) binding site [chemical binding]; other site
395491017912	active site
395491017913	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491017914	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
395491017915	active site
395491017916	motif I; other site
395491017917	motif II; other site
395491017918	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
395491017919	Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565
395491017920	active site
395491017921	catalytic site [active]
395491017922	metal binding site [ion binding]; metal-binding site
395491017923	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491017924	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017925	dimer interface [polypeptide binding]; other site
395491017926	conserved gate region; other site
395491017927	putative PBP binding loops; other site
395491017928	ABC-ATPase subunit interface; other site
395491017929	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395491017930	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395491017931	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491017932	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491017933	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491017934	Walker A/P-loop; other site
395491017935	ATP binding site [chemical binding]; other site
395491017936	Q-loop/lid; other site
395491017937	ABC transporter signature motif; other site
395491017938	Walker B; other site
395491017939	D-loop; other site
395491017940	H-loop/switch region; other site
395491017941	TOBE domain; Region: TOBE_2; pfam08402
395491017942	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
395491017943	DNA binding residues [nucleotide binding]
395491017944	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
395491017945	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
395491017946	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
395491017947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491017948	S-adenosylmethionine binding site [chemical binding]; other site
395491017949	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491017950	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491017951	DNA-binding site [nucleotide binding]; DNA binding site
395491017952	FCD domain; Region: FCD; pfam07729
395491017953	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
395491017954	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
395491017955	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491017956	Walker A/P-loop; other site
395491017957	ATP binding site [chemical binding]; other site
395491017958	Q-loop/lid; other site
395491017959	ABC transporter signature motif; other site
395491017960	Walker B; other site
395491017961	D-loop; other site
395491017962	H-loop/switch region; other site
395491017963	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395491017964	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
395491017965	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491017966	Walker A/P-loop; other site
395491017967	ATP binding site [chemical binding]; other site
395491017968	Q-loop/lid; other site
395491017969	ABC transporter signature motif; other site
395491017970	Walker B; other site
395491017971	D-loop; other site
395491017972	H-loop/switch region; other site
395491017973	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395491017974	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491017975	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
395491017976	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017977	dimer interface [polypeptide binding]; other site
395491017978	conserved gate region; other site
395491017979	putative PBP binding loops; other site
395491017980	ABC-ATPase subunit interface; other site
395491017981	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491017982	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491017983	dimer interface [polypeptide binding]; other site
395491017984	conserved gate region; other site
395491017985	putative PBP binding loops; other site
395491017986	ABC-ATPase subunit interface; other site
395491017987	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
395491017988	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
395491017989	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491017990	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
395491017991	inhibitor site; inhibition site
395491017992	active site
395491017993	dimer interface [polypeptide binding]; other site
395491017994	catalytic residue [active]
395491017995	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
395491017996	BNR repeat-like domain; Region: BNR_2; pfam13088
395491017997	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
395491017998	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
395491017999	putative active site [active]
395491018000	metal binding site [ion binding]; metal-binding site
395491018001	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
395491018002	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
395491018003	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
395491018004	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
395491018005	oligomeric interface; other site
395491018006	putative active site [active]
395491018007	homodimer interface [polypeptide binding]; other site
395491018008	Uncharacterized conserved protein [Function unknown]; Region: COG5654
395491018009	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
395491018010	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
395491018011	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395491018012	motif 1; other site
395491018013	dimer interface [polypeptide binding]; other site
395491018014	active site
395491018015	motif 2; other site
395491018016	motif 3; other site
395491018017	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491018018	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
395491018019	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395491018020	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395491018021	Walker A/P-loop; other site
395491018022	ATP binding site [chemical binding]; other site
395491018023	Q-loop/lid; other site
395491018024	ABC transporter signature motif; other site
395491018025	Walker B; other site
395491018026	D-loop; other site
395491018027	H-loop/switch region; other site
395491018028	NMT1/THI5 like; Region: NMT1; pfam09084
395491018029	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395491018030	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395491018031	membrane-bound complex binding site; other site
395491018032	hinge residues; other site
395491018033	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395491018034	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491018035	active site
395491018036	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395491018037	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491018038	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491018039	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491018040	MarR family; Region: MarR_2; pfam12802
395491018041	response regulator; Provisional; Region: PRK13435
395491018042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395491018043	active site
395491018044	phosphorylation site [posttranslational modification]
395491018045	intermolecular recognition site; other site
395491018046	dimerization interface [polypeptide binding]; other site
395491018047	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
395491018048	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
395491018049	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
395491018050	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491018051	dimer interface [polypeptide binding]; other site
395491018052	phosphorylation site [posttranslational modification]
395491018053	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491018054	ATP binding site [chemical binding]; other site
395491018055	Mg2+ binding site [ion binding]; other site
395491018056	G-X-G motif; other site
395491018057	Response regulator receiver domain; Region: Response_reg; pfam00072
395491018058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018059	active site
395491018060	phosphorylation site [posttranslational modification]
395491018061	intermolecular recognition site; other site
395491018062	dimerization interface [polypeptide binding]; other site
395491018063	BA14K-like protein; Region: BA14K; pfam07886
395491018064	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491018065	hypothetical protein; Provisional; Region: PRK07588
395491018066	hypothetical protein; Provisional; Region: PRK07236
395491018067	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
395491018068	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395491018069	catalytic residues [active]
395491018070	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
395491018071	cleavage site
395491018072	active site
395491018073	substrate binding sites [chemical binding]; other site
395491018074	Caspase domain; Region: Peptidase_C14; pfam00656
395491018075	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
395491018076	cleavage site
395491018077	active site
395491018078	substrate binding sites [chemical binding]; other site
395491018079	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
395491018080	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
395491018081	active site
395491018082	catalytic triad [active]
395491018083	calcium binding site [ion binding]; other site
395491018084	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
395491018085	active site
395491018086	catalytic residues [active]
395491018087	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
395491018088	PLD-like domain; Region: PLDc_2; pfam13091
395491018089	putative active site [active]
395491018090	catalytic site [active]
395491018091	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128
395491018092	PLD-like domain; Region: PLDc_2; pfam13091
395491018093	putative active site [active]
395491018094	putative catalytic site [active]
395491018095	TIGR02646 family protein; Region: TIGR02646
395491018096	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491018097	AAA domain; Region: AAA_21; pfam13304
395491018098	Walker A/P-loop; other site
395491018099	ATP binding site [chemical binding]; other site
395491018100	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
395491018101	TIGR02646 family protein; Region: TIGR02646
395491018102	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
395491018103	Transposase; Region: HTH_Tnp_1; pfam01527
395491018104	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
395491018105	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
395491018106	active site
395491018107	NTP binding site [chemical binding]; other site
395491018108	nucleic acid binding site [nucleotide binding]; other site
395491018109	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
395491018110	Part of AAA domain; Region: AAA_19; pfam13245
395491018111	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491018112	AAA domain; Region: AAA_23; pfam13476
395491018113	Walker A/P-loop; other site
395491018114	ATP binding site [chemical binding]; other site
395491018115	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
395491018116	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
395491018117	putative active site [active]
395491018118	putative metal-binding site [ion binding]; other site
395491018119	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
395491018120	HTH DNA binding domain; Region: HTH_13; pfam11972
395491018121	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
395491018122	DNA binding site [nucleotide binding]
395491018123	dimer interface [polypeptide binding]; other site
395491018124	active site
395491018125	Int/Topo IB signature motif; other site
395491018126	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
395491018127	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491018128	Walker A motif; other site
395491018129	ATP binding site [chemical binding]; other site
395491018130	Walker B motif; other site
395491018131	arginine finger; other site
395491018132	Fic family protein [Function unknown]; Region: COG3177
395491018133	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
395491018134	Fic/DOC family; Region: Fic; pfam02661
395491018135	Replication protein C N-terminal domain; Region: RP-C; pfam03428
395491018136	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
395491018137	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
395491018138	ParB-like nuclease domain; Region: ParBc; pfam02195
395491018139	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
395491018140	MerR family regulatory protein; Region: MerR; pfam00376
395491018141	DNA binding residues [nucleotide binding]
395491018142	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491018143	P-loop; other site
395491018144	Magnesium ion binding site [ion binding]; other site
395491018145	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491018146	Magnesium ion binding site [ion binding]; other site
395491018147	putative autoinducer synthesis protein; Provisional; Region: PRK13834
395491018148	conjugal transfer protein TrbB; Provisional; Region: PRK13833
395491018149	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
395491018150	ATP binding site [chemical binding]; other site
395491018151	Walker A motif; other site
395491018152	hexamer interface [polypeptide binding]; other site
395491018153	Walker B motif; other site
395491018154	conjugal transfer protein TrbC; Provisional; Region: PRK13871
395491018155	conjugal transfer protein TrbD; Provisional; Region: PRK13823
395491018156	conjugal transfer protein TrbE; Provisional; Region: PRK13830
395491018157	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
395491018158	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491018159	Walker A/P-loop; other site
395491018160	ATP binding site [chemical binding]; other site
395491018161	conjugal transfer protein TrbJ; Provisional; Region: PRK13842
395491018162	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
395491018163	conjugal transfer protein TrbL; Provisional; Region: PRK13841
395491018164	conjugal transfer protein TrbF; Provisional; Region: PRK13836
395491018165	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
395491018166	VirB7 interaction site; other site
395491018167	conjugal transfer protein TrbH; Provisional; Region: PRK13835
395491018168	Conjugal transfer protein TrbH; Region: TrbH; pfam07283
395491018169	conjugal transfer protein TrbI; Provisional; Region: PRK13831
395491018170	transcriptional regulator TraR; Provisional; Region: PRK13870
395491018171	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395491018172	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491018173	DNA binding residues [nucleotide binding]
395491018174	dimerization interface [polypeptide binding]; other site
395491018175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
395491018176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018177	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491018178	active site
395491018179	phosphorylation site [posttranslational modification]
395491018180	intermolecular recognition site; other site
395491018181	dimerization interface [polypeptide binding]; other site
395491018182	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491018183	DNA binding site [nucleotide binding]
395491018184	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491018185	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491018186	DNA binding site [nucleotide binding]
395491018187	Amidohydrolase; Region: Amidohydro_5; pfam13594
395491018188	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491018189	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
395491018190	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
395491018191	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
395491018192	nitrilase; Region: PLN02798
395491018193	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
395491018194	putative active site [active]
395491018195	catalytic triad [active]
395491018196	dimer interface [polypeptide binding]; other site
395491018197	hypothetical protein; Validated; Region: PRK06201
395491018198	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
395491018199	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
395491018200	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
395491018201	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395491018202	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491018203	Walker A/P-loop; other site
395491018204	ATP binding site [chemical binding]; other site
395491018205	Q-loop/lid; other site
395491018206	ABC transporter signature motif; other site
395491018207	Walker B; other site
395491018208	D-loop; other site
395491018209	H-loop/switch region; other site
395491018210	TOBE domain; Region: TOBE_2; pfam08402
395491018211	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491018212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491018213	dimer interface [polypeptide binding]; other site
395491018214	conserved gate region; other site
395491018215	putative PBP binding loops; other site
395491018216	ABC-ATPase subunit interface; other site
395491018217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491018218	dimer interface [polypeptide binding]; other site
395491018219	conserved gate region; other site
395491018220	putative PBP binding loops; other site
395491018221	ABC-ATPase subunit interface; other site
395491018222	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395491018223	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395491018224	Protein of unknown function (DUF433); Region: DUF433; pfam04255
395491018225	conjugal transfer protein TraH; Provisional; Region: PRK13843
395491018226	conjugal transfer protein TraB; Provisional; Region: PRK13825
395491018227	active site
395491018228	catalytic triad [active]
395491018229	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
395491018230	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
395491018231	Dtr system oriT relaxase; Provisional; Region: PRK13826
395491018232	MobA/MobL family; Region: MobA_MobL; pfam03389
395491018233	AAA domain; Region: AAA_30; pfam13604
395491018234	Family description; Region: UvrD_C_2; pfam13538
395491018235	conjugal transfer protein TraC; Provisional; Region: PRK13848
395491018236	conjugal transfer protein TraD; Provisional; Region: PRK13847
395491018237	conjugal transfer coupling protein TraG; Provisional; Region: PRK13822
395491018238	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395491018239	Walker A motif; other site
395491018240	ATP binding site [chemical binding]; other site
395491018241	Walker B motif; other site
395491018242	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
395491018243	Protein of unknown function (DUF736); Region: DUF736; pfam05284
395491018244	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
395491018245	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
395491018246	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
395491018247	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
395491018248	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
395491018249	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491018250	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491018251	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395491018252	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
395491018253	active site
395491018254	C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343
395491018255	active site
395491018256	metal binding site [ion binding]; metal-binding site
395491018257	glutathionine S-transferase; Provisional; Region: PRK10542
395491018258	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
395491018259	C-terminal domain interface [polypeptide binding]; other site
395491018260	GSH binding site (G-site) [chemical binding]; other site
395491018261	dimer interface [polypeptide binding]; other site
395491018262	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
395491018263	dimer interface [polypeptide binding]; other site
395491018264	N-terminal domain interface [polypeptide binding]; other site
395491018265	substrate binding pocket (H-site) [chemical binding]; other site
395491018266	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
395491018267	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
395491018268	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491018269	putative substrate translocation pore; other site
395491018270	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491018271	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395491018272	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395491018273	active site
395491018274	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
395491018275	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395491018276	MarR family; Region: MarR; pfam01047
395491018277	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
395491018278	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
395491018279	dimer interface [polypeptide binding]; other site
395491018280	active site
395491018281	FAD binding domain; Region: FAD_binding_3; pfam01494
395491018282	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395491018283	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395491018284	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395491018285	TM-ABC transporter signature motif; other site
395491018286	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395491018287	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491018288	TM-ABC transporter signature motif; other site
395491018289	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
395491018290	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395491018291	Walker A/P-loop; other site
395491018292	ATP binding site [chemical binding]; other site
395491018293	Q-loop/lid; other site
395491018294	ABC transporter signature motif; other site
395491018295	Walker B; other site
395491018296	D-loop; other site
395491018297	H-loop/switch region; other site
395491018298	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395491018299	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395491018300	Walker A/P-loop; other site
395491018301	ATP binding site [chemical binding]; other site
395491018302	Q-loop/lid; other site
395491018303	ABC transporter signature motif; other site
395491018304	Walker B; other site
395491018305	D-loop; other site
395491018306	H-loop/switch region; other site
395491018307	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395491018308	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337
395491018309	putative ligand binding site [chemical binding]; other site
395491018310	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
395491018311	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
395491018312	active site
395491018313	dimer interface [polypeptide binding]; other site
395491018314	metal binding site [ion binding]; metal-binding site
395491018315	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
395491018316	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
395491018317	active site
395491018318	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491018319	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491018320	LysR substrate binding domain; Region: LysR_substrate; pfam03466
395491018321	dimerization interface [polypeptide binding]; other site
395491018322	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
395491018323	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
395491018324	osmolarity response regulator; Provisional; Region: ompR; PRK09468
395491018325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018326	active site
395491018327	phosphorylation site [posttranslational modification]
395491018328	intermolecular recognition site; other site
395491018329	dimerization interface [polypeptide binding]; other site
395491018330	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491018331	DNA binding site [nucleotide binding]
395491018332	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
395491018333	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
395491018334	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
395491018335	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
395491018336	Protein of unknown function DUF72; Region: DUF72; pfam01904
395491018337	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395491018338	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
395491018339	putative dimer interface [polypeptide binding]; other site
395491018340	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491018341	hypothetical protein; Provisional; Region: PRK13559
395491018342	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491018343	putative active site [active]
395491018344	heme pocket [chemical binding]; other site
395491018345	HWE histidine kinase; Region: HWE_HK; smart00911
395491018346	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491018347	PAS domain; Region: PAS_9; pfam13426
395491018348	putative active site [active]
395491018349	heme pocket [chemical binding]; other site
395491018350	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395491018351	HWE histidine kinase; Region: HWE_HK; smart00911
395491018352	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
395491018353	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395491018354	NAD binding site [chemical binding]; other site
395491018355	catalytic Zn binding site [ion binding]; other site
395491018356	structural Zn binding site [ion binding]; other site
395491018357	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
395491018358	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491018359	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491018360	ligand binding site [chemical binding]; other site
395491018361	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491018362	Response regulator receiver domain; Region: Response_reg; pfam00072
395491018363	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018364	active site
395491018365	phosphorylation site [posttranslational modification]
395491018366	intermolecular recognition site; other site
395491018367	dimerization interface [polypeptide binding]; other site
395491018368	thiamine pyrophosphate protein; Provisional; Region: PRK08273
395491018369	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
395491018370	PYR/PP interface [polypeptide binding]; other site
395491018371	dimer interface [polypeptide binding]; other site
395491018372	tetramer interface [polypeptide binding]; other site
395491018373	TPP binding site [chemical binding]; other site
395491018374	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395491018375	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
395491018376	TPP-binding site [chemical binding]; other site
395491018377	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
395491018378	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
395491018379	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491018380	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491018381	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491018382	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395491018383	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269
395491018384	putative NAD(P) binding site [chemical binding]; other site
395491018385	catalytic Zn binding site [ion binding]; other site
395491018386	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491018387	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491018388	NAD(P) binding site [chemical binding]; other site
395491018389	active site
395491018390	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
395491018391	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491018392	NAD binding site [chemical binding]; other site
395491018393	homotetramer interface [polypeptide binding]; other site
395491018394	homodimer interface [polypeptide binding]; other site
395491018395	active site
395491018396	substrate binding site [chemical binding]; other site
395491018397	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
395491018398	Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579
395491018399	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491018400	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395491018401	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
395491018402	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
395491018403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
395491018404	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
395491018405	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
395491018406	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
395491018407	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
395491018408	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491018409	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491018410	NAD(P) binding site [chemical binding]; other site
395491018411	active site
395491018412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491018413	S-adenosylmethionine binding site [chemical binding]; other site
395491018414	Cytochrome P450; Region: p450; cl12078
395491018415	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
395491018416	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491018417	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395491018418	classical (c) SDRs; Region: SDR_c; cd05233
395491018419	NAD(P) binding site [chemical binding]; other site
395491018420	active site
395491018421	RNA polymerase sigma factor; Provisional; Region: PRK12547
395491018422	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491018423	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
395491018424	DNA binding residues [nucleotide binding]
395491018425	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
395491018426	dimerization interface [polypeptide binding]; other site
395491018427	metal binding site [ion binding]; metal-binding site
395491018428	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
395491018429	Asp-box motif; other site
395491018430	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491018431	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491018432	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
395491018433	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
395491018434	FAD dependent oxidoreductase; Region: DAO; pfam01266
395491018435	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
395491018436	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
395491018437	putative active site [active]
395491018438	putative PHP Thumb interface [polypeptide binding]; other site
395491018439	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
395491018440	generic binding surface I; other site
395491018441	generic binding surface II; other site
395491018442	DNA Polymerase Y-family; Region: PolY_like; cd03468
395491018443	active site
395491018444	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
395491018445	DNA binding site [nucleotide binding]
395491018446	Uncharacterized conserved protein [Function unknown]; Region: COG4544
395491018447	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
395491018448	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
395491018449	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491018450	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395491018451	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
395491018452	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491018453	putative homodimer interface [polypeptide binding]; other site
395491018454	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
395491018455	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395491018456	UDP-galactopyranose mutase; Region: GLF; pfam03275
395491018457	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491018458	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395491018459	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491018460	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491018461	Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635
395491018462	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
395491018463	putative NAD(P) binding site [chemical binding]; other site
395491018464	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395491018465	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491018466	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395491018467	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
395491018468	short chain dehydrogenase; Provisional; Region: PRK06701
395491018469	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
395491018470	NAD binding site [chemical binding]; other site
395491018471	metal binding site [ion binding]; metal-binding site
395491018472	active site
395491018473	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
395491018474	metal binding site [ion binding]; metal-binding site
395491018475	dimerization interface [polypeptide binding]; other site
395491018476	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
395491018477	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
395491018478	CGNR zinc finger; Region: zf-CGNR; pfam11706
395491018479	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
395491018480	EamA-like transporter family; Region: EamA; pfam00892
395491018481	EamA-like transporter family; Region: EamA; pfam00892
395491018482	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
395491018483	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491018484	FecR protein; Region: FecR; pfam04773
395491018485	CHASE2 domain; Region: CHASE2; pfam05226
395491018486	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491018487	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491018488	metal binding site [ion binding]; metal-binding site
395491018489	active site
395491018490	I-site; other site
395491018491	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491018492	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491018493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018494	active site
395491018495	phosphorylation site [posttranslational modification]
395491018496	intermolecular recognition site; other site
395491018497	dimerization interface [polypeptide binding]; other site
395491018498	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491018499	DNA binding residues [nucleotide binding]
395491018500	dimerization interface [polypeptide binding]; other site
395491018501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491018502	putative substrate translocation pore; other site
395491018503	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491018504	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
395491018505	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
395491018506	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
395491018507	active site
395491018508	DNA binding site [nucleotide binding]
395491018509	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
395491018510	DNA binding site [nucleotide binding]
395491018511	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
395491018512	nucleotide binding site [chemical binding]; other site
395491018513	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395491018514	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
395491018515	putative dimer interface [polypeptide binding]; other site
395491018516	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491018517	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
395491018518	Response regulator receiver domain; Region: Response_reg; pfam00072
395491018519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018520	active site
395491018521	phosphorylation site [posttranslational modification]
395491018522	intermolecular recognition site; other site
395491018523	dimerization interface [polypeptide binding]; other site
395491018524	two component system sensor kinase SsrB; Provisional; Region: PRK15369
395491018525	Response regulator receiver domain; Region: Response_reg; pfam00072
395491018526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018527	active site
395491018528	phosphorylation site [posttranslational modification]
395491018529	intermolecular recognition site; other site
395491018530	dimerization interface [polypeptide binding]; other site
395491018531	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
395491018532	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491018533	non-specific DNA binding site [nucleotide binding]; other site
395491018534	salt bridge; other site
395491018535	sequence-specific DNA binding site [nucleotide binding]; other site
395491018536	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395491018537	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
395491018538	nucleophile elbow; other site
395491018539	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395491018540	Protein export membrane protein; Region: SecD_SecF; cl14618
395491018541	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395491018542	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395491018543	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491018544	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
395491018545	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491018546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018547	active site
395491018548	phosphorylation site [posttranslational modification]
395491018549	intermolecular recognition site; other site
395491018550	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
395491018551	putative active site [active]
395491018552	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491018553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491018554	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395491018555	putative effector binding pocket; other site
395491018556	putative dimerization interface [polypeptide binding]; other site
395491018557	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395491018558	extended (e) SDRs; Region: SDR_e; cd08946
395491018559	NAD(P) binding site [chemical binding]; other site
395491018560	active site
395491018561	substrate binding site [chemical binding]; other site
395491018562	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491018563	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491018564	active site
395491018565	catalytic tetrad [active]
395491018566	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491018567	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491018568	active site
395491018569	catalytic tetrad [active]
395491018570	short chain dehydrogenase; Validated; Region: PRK08264
395491018571	classical (c) SDRs; Region: SDR_c; cd05233
395491018572	NAD(P) binding site [chemical binding]; other site
395491018573	active site
395491018574	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491018575	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395491018576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491018577	dimer interface [polypeptide binding]; other site
395491018578	conserved gate region; other site
395491018579	putative PBP binding loops; other site
395491018580	ABC-ATPase subunit interface; other site
395491018581	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491018582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491018583	dimer interface [polypeptide binding]; other site
395491018584	conserved gate region; other site
395491018585	putative PBP binding loops; other site
395491018586	ABC-ATPase subunit interface; other site
395491018587	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
395491018588	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
395491018589	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
395491018590	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491018591	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491018592	DNA binding site [nucleotide binding]
395491018593	domain linker motif; other site
395491018594	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491018595	dimerization interface [polypeptide binding]; other site
395491018596	ligand binding site [chemical binding]; other site
395491018597	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491018598	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491018599	Walker A/P-loop; other site
395491018600	ATP binding site [chemical binding]; other site
395491018601	Q-loop/lid; other site
395491018602	ABC transporter signature motif; other site
395491018603	Walker B; other site
395491018604	D-loop; other site
395491018605	H-loop/switch region; other site
395491018606	TOBE domain; Region: TOBE_2; pfam08402
395491018607	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
395491018608	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
395491018609	putative NAD(P) binding site [chemical binding]; other site
395491018610	putative active site [active]
395491018611	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491018612	classical (c) SDRs; Region: SDR_c; cd05233
395491018613	NAD(P) binding site [chemical binding]; other site
395491018614	active site
395491018615	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
395491018616	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491018617	active site
395491018618	hypothetical protein; Provisional; Region: PRK06154
395491018619	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395491018620	PYR/PP interface [polypeptide binding]; other site
395491018621	dimer interface [polypeptide binding]; other site
395491018622	TPP binding site [chemical binding]; other site
395491018623	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395491018624	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
395491018625	TPP-binding site; other site
395491018626	dimer interface [polypeptide binding]; other site
395491018627	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
395491018628	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
395491018629	active site
395491018630	catalytic site [active]
395491018631	tetramer interface [polypeptide binding]; other site
395491018632	extended (e) SDRs; Region: SDR_e; cd08946
395491018633	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
395491018634	NAD(P) binding site [chemical binding]; other site
395491018635	active site
395491018636	substrate binding site [chemical binding]; other site
395491018637	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
395491018638	classical (c) SDRs; Region: SDR_c; cd05233
395491018639	NAD(P) binding site [chemical binding]; other site
395491018640	active site
395491018641	dihydropyrimidinase; Provisional; Region: PRK13404
395491018642	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
395491018643	tetramer interface [polypeptide binding]; other site
395491018644	active site
395491018645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491018646	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395491018647	putative substrate translocation pore; other site
395491018648	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
395491018649	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491018650	Walker A/P-loop; other site
395491018651	ATP binding site [chemical binding]; other site
395491018652	Q-loop/lid; other site
395491018653	ABC transporter signature motif; other site
395491018654	Walker B; other site
395491018655	D-loop; other site
395491018656	H-loop/switch region; other site
395491018657	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
395491018658	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491018659	Walker A/P-loop; other site
395491018660	ATP binding site [chemical binding]; other site
395491018661	Q-loop/lid; other site
395491018662	ABC transporter signature motif; other site
395491018663	Walker B; other site
395491018664	D-loop; other site
395491018665	H-loop/switch region; other site
395491018666	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491018667	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491018668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491018669	dimer interface [polypeptide binding]; other site
395491018670	conserved gate region; other site
395491018671	ABC-ATPase subunit interface; other site
395491018672	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491018673	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491018674	dimer interface [polypeptide binding]; other site
395491018675	conserved gate region; other site
395491018676	putative PBP binding loops; other site
395491018677	ABC-ATPase subunit interface; other site
395491018678	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491018679	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
395491018680	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395491018681	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
395491018682	conserved cys residue [active]
395491018683	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491018684	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491018685	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491018686	Walker A/P-loop; other site
395491018687	ATP binding site [chemical binding]; other site
395491018688	Q-loop/lid; other site
395491018689	ABC transporter signature motif; other site
395491018690	Walker B; other site
395491018691	D-loop; other site
395491018692	H-loop/switch region; other site
395491018693	TOBE domain; Region: TOBE; pfam03459
395491018694	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491018695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491018696	dimer interface [polypeptide binding]; other site
395491018697	conserved gate region; other site
395491018698	putative PBP binding loops; other site
395491018699	ABC-ATPase subunit interface; other site
395491018700	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491018701	dimer interface [polypeptide binding]; other site
395491018702	conserved gate region; other site
395491018703	putative PBP binding loops; other site
395491018704	ABC-ATPase subunit interface; other site
395491018705	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491018706	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491018707	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491018708	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491018709	DNA-binding site [nucleotide binding]; DNA binding site
395491018710	FCD domain; Region: FCD; pfam07729
395491018711	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
395491018712	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
395491018713	metal binding site [ion binding]; metal-binding site
395491018714	substrate binding pocket [chemical binding]; other site
395491018715	TspO/MBR family; Region: TspO_MBR; pfam03073
395491018716	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
395491018717	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491018718	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
395491018719	putative dimerization interface [polypeptide binding]; other site
395491018720	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395491018721	active site
395491018722	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
395491018723	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
395491018724	Na binding site [ion binding]; other site
395491018725	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
395491018726	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491018727	hypothetical protein; Provisional; Region: PRK06102
395491018728	Amidase; Region: Amidase; cl11426
395491018729	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
395491018730	active site
395491018731	catalytic site [active]
395491018732	Zn binding site [ion binding]; other site
395491018733	tetramer interface [polypeptide binding]; other site
395491018734	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
395491018735	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
395491018736	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491018737	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491018738	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491018739	dimerization interface [polypeptide binding]; other site
395491018740	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491018741	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
395491018742	AP (apurinic/apyrimidinic) site pocket; other site
395491018743	DNA interaction; other site
395491018744	Metal-binding active site; metal-binding site
395491018745	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
395491018746	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395491018747	NAD(P) binding site [chemical binding]; other site
395491018748	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
395491018749	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395491018750	IHF dimer interface [polypeptide binding]; other site
395491018751	IHF - DNA interface [nucleotide binding]; other site
395491018752	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
395491018753	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491018754	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491018755	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
395491018756	dimerization interface [polypeptide binding]; other site
395491018757	substrate binding pocket [chemical binding]; other site
395491018758	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491018759	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491018760	non-specific DNA binding site [nucleotide binding]; other site
395491018761	salt bridge; other site
395491018762	sequence-specific DNA binding site [nucleotide binding]; other site
395491018763	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
395491018764	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
395491018765	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395491018766	ATP binding site [chemical binding]; other site
395491018767	putative Mg++ binding site [ion binding]; other site
395491018768	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491018769	nucleotide binding region [chemical binding]; other site
395491018770	ATP-binding site [chemical binding]; other site
395491018771	TRCF domain; Region: TRCF; pfam03461
395491018772	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491018773	Major royal jelly protein; Region: MRJP; pfam03022
395491018774	PAS domain S-box; Region: sensory_box; TIGR00229
395491018775	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491018776	putative active site [active]
395491018777	heme pocket [chemical binding]; other site
395491018778	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395491018779	GAF domain; Region: GAF; pfam01590
395491018780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491018781	ATP binding site [chemical binding]; other site
395491018782	Mg2+ binding site [ion binding]; other site
395491018783	G-X-G motif; other site
395491018784	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491018785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018786	active site
395491018787	phosphorylation site [posttranslational modification]
395491018788	intermolecular recognition site; other site
395491018789	dimerization interface [polypeptide binding]; other site
395491018790	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395491018791	HWE histidine kinase; Region: HWE_HK; pfam07536
395491018792	RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467
395491018793	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395491018794	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
395491018795	Walker A motif; other site
395491018796	Walker A motif; other site
395491018797	ATP binding site [chemical binding]; other site
395491018798	Walker B motif; other site
395491018799	KaiC; Region: KaiC; pfam06745
395491018800	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
395491018801	Walker A motif; other site
395491018802	ATP binding site [chemical binding]; other site
395491018803	Walker B motif; other site
395491018804	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
395491018805	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
395491018806	oligomer interface [polypeptide binding]; other site
395491018807	metal binding site [ion binding]; metal-binding site
395491018808	metal binding site [ion binding]; metal-binding site
395491018809	putative Cl binding site [ion binding]; other site
395491018810	basic sphincter; other site
395491018811	hydrophobic gate; other site
395491018812	periplasmic entrance; other site
395491018813	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395491018814	Zn2+ binding site [ion binding]; other site
395491018815	Mg2+ binding site [ion binding]; other site
395491018816	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
395491018817	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395491018818	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
395491018819	putative NAD(P) binding site [chemical binding]; other site
395491018820	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395491018821	Zn2+ binding site [ion binding]; other site
395491018822	Mg2+ binding site [ion binding]; other site
395491018823	Response regulator receiver domain; Region: Response_reg; pfam00072
395491018824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018825	active site
395491018826	phosphorylation site [posttranslational modification]
395491018827	intermolecular recognition site; other site
395491018828	dimerization interface [polypeptide binding]; other site
395491018829	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
395491018830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018831	active site
395491018832	phosphorylation site [posttranslational modification]
395491018833	intermolecular recognition site; other site
395491018834	dimerization interface [polypeptide binding]; other site
395491018835	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491018836	DNA binding residues [nucleotide binding]
395491018837	dimerization interface [polypeptide binding]; other site
395491018838	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
395491018839	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
395491018840	substrate binding site [chemical binding]; other site
395491018841	activation loop (A-loop); other site
395491018842	AAA ATPase domain; Region: AAA_16; pfam13191
395491018843	Predicted ATPase [General function prediction only]; Region: COG3899
395491018844	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395491018845	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395491018846	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491018847	PAS domain; Region: PAS_9; pfam13426
395491018848	putative active site [active]
395491018849	heme pocket [chemical binding]; other site
395491018850	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491018851	dimer interface [polypeptide binding]; other site
395491018852	phosphorylation site [posttranslational modification]
395491018853	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491018854	ATP binding site [chemical binding]; other site
395491018855	Mg2+ binding site [ion binding]; other site
395491018856	G-X-G motif; other site
395491018857	short chain dehydrogenase; Provisional; Region: PRK12746
395491018858	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491018859	NAD(P) binding site [chemical binding]; other site
395491018860	active site
395491018861	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491018862	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491018863	short chain dehydrogenase; Provisional; Region: PRK07041
395491018864	classical (c) SDRs; Region: SDR_c; cd05233
395491018865	NAD(P) binding site [chemical binding]; other site
395491018866	active site
395491018867	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491018868	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491018869	NAD(P) binding site [chemical binding]; other site
395491018870	active site
395491018871	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491018872	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491018873	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491018874	putative effector binding pocket; other site
395491018875	dimerization interface [polypeptide binding]; other site
395491018876	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491018877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491018878	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
395491018879	putative effector binding pocket; other site
395491018880	putative dimerization interface [polypeptide binding]; other site
395491018881	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
395491018882	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395491018883	putative NAD(P) binding site [chemical binding]; other site
395491018884	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491018885	ATP binding site [chemical binding]; other site
395491018886	Mg2+ binding site [ion binding]; other site
395491018887	G-X-G motif; other site
395491018888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018889	active site
395491018890	phosphorylation site [posttranslational modification]
395491018891	intermolecular recognition site; other site
395491018892	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
395491018893	PLD-like domain; Region: PLDc_2; pfam13091
395491018894	putative active site [active]
395491018895	catalytic site [active]
395491018896	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
395491018897	PLD-like domain; Region: PLDc_2; pfam13091
395491018898	putative active site [active]
395491018899	catalytic site [active]
395491018900	circadian clock protein KaiC; Reviewed; Region: PRK09302
395491018901	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395491018902	Walker A motif; other site
395491018903	ATP binding site [chemical binding]; other site
395491018904	Walker B motif; other site
395491018905	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
395491018906	Walker A motif; other site
395491018907	ATP binding site [chemical binding]; other site
395491018908	Walker B motif; other site
395491018909	PAS fold; Region: PAS_3; pfam08447
395491018910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491018911	ATP binding site [chemical binding]; other site
395491018912	Mg2+ binding site [ion binding]; other site
395491018913	G-X-G motif; other site
395491018914	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491018915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491018916	active site
395491018917	phosphorylation site [posttranslational modification]
395491018918	intermolecular recognition site; other site
395491018919	dimerization interface [polypeptide binding]; other site
395491018920	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491018921	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
395491018922	ligand binding site [chemical binding]; other site
395491018923	flexible hinge region; other site
395491018924	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491018925	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491018926	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
395491018927	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491018928	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491018929	S-formylglutathione hydrolase; Region: PLN02442
395491018930	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
395491018931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395491018932	active site
395491018933	phosphorylation site [posttranslational modification]
395491018934	intermolecular recognition site; other site
395491018935	dimerization interface [polypeptide binding]; other site
395491018936	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
395491018937	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
395491018938	short chain dehydrogenase; Provisional; Region: PRK06139
395491018939	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
395491018940	putative NAD(P) binding site [chemical binding]; other site
395491018941	active site
395491018942	hypothetical protein; Validated; Region: PRK08238
395491018943	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
395491018944	GtrA-like protein; Region: GtrA; pfam04138
395491018945	FAD binding domain; Region: FAD_binding_4; pfam01565
395491018946	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
395491018947	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395491018948	classical (c) SDRs; Region: SDR_c; cd05233
395491018949	NAD(P) binding site [chemical binding]; other site
395491018950	active site
395491018951	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
395491018952	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
395491018953	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
395491018954	NADH dehydrogenase subunit D; Validated; Region: PRK06075
395491018955	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
395491018956	proposed catalytic triad [active]
395491018957	active site nucleophile [active]
395491018958	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
395491018959	active site
395491018960	dimer interface [polypeptide binding]; other site
395491018961	catalytic nucleophile [active]
395491018962	cyanophycin synthetase; Provisional; Region: PRK14016
395491018963	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395491018964	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395491018965	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395491018966	Domain of unknown function (DUF892); Region: DUF892; pfam05974
395491018967	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
395491018968	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
395491018969	dimanganese center [ion binding]; other site
395491018970	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395491018971	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
395491018972	NADH dehydrogenase subunit B; Validated; Region: PRK06411
395491018973	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
395491018974	catalytic site [active]
395491018975	Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002
395491018976	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491018977	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395491018978	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
395491018979	proximal heme binding site [chemical binding]; other site
395491018980	Iron-sulfur protein interface; other site
395491018981	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491018982	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
395491018983	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
395491018984	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395491018985	NAD binding site [chemical binding]; other site
395491018986	catalytic Zn binding site [ion binding]; other site
395491018987	structural Zn binding site [ion binding]; other site
395491018988	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395491018989	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
395491018990	substrate binding pocket [chemical binding]; other site
395491018991	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
395491018992	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
395491018993	putative molybdopterin cofactor binding site [chemical binding]; other site
395491018994	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
395491018995	putative molybdopterin cofactor binding site; other site
395491018996	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395491018997	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
395491018998	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
395491018999	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
395491019000	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
395491019001	Cytochrome c; Region: Cytochrom_C; pfam00034
395491019002	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
395491019003	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
395491019004	D-pathway; other site
395491019005	Putative ubiquinol binding site [chemical binding]; other site
395491019006	Low-spin heme (heme b) binding site [chemical binding]; other site
395491019007	Putative water exit pathway; other site
395491019008	Binuclear center (heme o3/CuB) [ion binding]; other site
395491019009	K-pathway; other site
395491019010	Putative proton exit pathway; other site
395491019011	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
395491019012	Subunit I/III interface [polypeptide binding]; other site
395491019013	Cytochrome c; Region: Cytochrom_C; cl11414
395491019014	Cytochrome c; Region: Cytochrom_C; pfam00034
395491019015	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395491019016	Cytochrome c; Region: Cytochrom_C; pfam00034
395491019017	Low affinity iron permease; Region: Iron_permease; cl12096
395491019018	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
395491019019	nudix motif; other site
395491019020	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
395491019021	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
395491019022	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491019023	NAD(P) binding site [chemical binding]; other site
395491019024	active site
395491019025	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
395491019026	Helix-turn-helix domain; Region: HTH_18; pfam12833
395491019027	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491019028	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491019029	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491019030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685
395491019031	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
395491019032	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395491019033	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491019034	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491019035	Usg-like family; Region: Usg; cl11567
395491019036	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
395491019037	oligomerisation interface [polypeptide binding]; other site
395491019038	mobile loop; other site
395491019039	roof hairpin; other site
395491019040	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
395491019041	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
395491019042	ring oligomerisation interface [polypeptide binding]; other site
395491019043	ATP/Mg binding site [chemical binding]; other site
395491019044	stacking interactions; other site
395491019045	hinge regions; other site
395491019046	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
395491019047	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491019048	putative ADP-binding pocket [chemical binding]; other site
395491019049	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
395491019050	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
395491019051	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
395491019052	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
395491019053	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
395491019054	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
395491019055	classical (c) SDRs; Region: SDR_c; cd05233
395491019056	NAD(P) binding site [chemical binding]; other site
395491019057	active site
395491019058	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491019059	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491019060	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491019061	dimerization interface [polypeptide binding]; other site
395491019062	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
395491019063	putative active site [active]
395491019064	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
395491019065	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
395491019066	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
395491019067	homodimer interface [polypeptide binding]; other site
395491019068	acceptor substrate-binding pocket; other site
395491019069	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
395491019070	dimerization interface [polypeptide binding]; other site
395491019071	Domain of unknown function (DUF305); Region: DUF305; cl17794
395491019072	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491019073	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491019074	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
395491019075	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
395491019076	Domain of unknown function (DUF955); Region: DUF955; cl01076
395491019077	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491019078	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
395491019079	ligand binding site [chemical binding]; other site
395491019080	flexible hinge region; other site
395491019081	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491019082	succinate dehydrogenase, hydrophobic membrane anchor protein; Region: succ_dehyd_anc; TIGR02968
395491019083	proximal heme binding site [chemical binding]; other site
395491019084	Iron-sulfur protein interface; other site
395491019085	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
395491019086	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395491019087	RNA binding surface [nucleotide binding]; other site
395491019088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491019089	PAS domain; Region: PAS_9; pfam13426
395491019090	putative active site [active]
395491019091	heme pocket [chemical binding]; other site
395491019092	PAS domain S-box; Region: sensory_box; TIGR00229
395491019093	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491019094	putative active site [active]
395491019095	heme pocket [chemical binding]; other site
395491019096	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395491019097	Histidine kinase; Region: HisKA_2; pfam07568
395491019098	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491019099	ATP binding site [chemical binding]; other site
395491019100	Mg2+ binding site [ion binding]; other site
395491019101	G-X-G motif; other site
395491019102	Domain of unknown function (DUF378); Region: DUF378; pfam04070
395491019103	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
395491019104	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
395491019105	short chain dehydrogenase; Provisional; Region: PRK06139
395491019106	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
395491019107	putative NAD(P) binding site [chemical binding]; other site
395491019108	active site
395491019109	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
395491019110	Cytochrome P450; Region: p450; cl12078
395491019111	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491019112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395491019113	active site
395491019114	phosphorylation site [posttranslational modification]
395491019115	intermolecular recognition site; other site
395491019116	dimerization interface [polypeptide binding]; other site
395491019117	oxidoreductase; Provisional; Region: PRK06128
395491019118	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491019119	NAD(P) binding site [chemical binding]; other site
395491019120	active site
395491019121	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395491019122	classical (c) SDRs; Region: SDR_c; cd05233
395491019123	NAD(P) binding site [chemical binding]; other site
395491019124	active site
395491019125	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
395491019126	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
395491019127	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
395491019128	Fe-S cluster binding site [ion binding]; other site
395491019129	active site
395491019130	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
395491019131	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
395491019132	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491019133	S-adenosylmethionine binding site [chemical binding]; other site
395491019134	Erythromycin esterase; Region: Erythro_esteras; pfam05139
395491019135	Predicted ATPase [General function prediction only]; Region: COG3899
395491019136	AAA ATPase domain; Region: AAA_16; pfam13191
395491019137	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491019138	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491019139	DNA binding residues [nucleotide binding]
395491019140	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
395491019141	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491019142	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491019143	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
395491019144	dimerization interface [polypeptide binding]; other site
395491019145	substrate binding pocket [chemical binding]; other site
395491019146	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491019147	non-specific DNA binding site [nucleotide binding]; other site
395491019148	salt bridge; other site
395491019149	sequence-specific DNA binding site [nucleotide binding]; other site
395491019150	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
395491019151	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395491019152	DNA-binding site [nucleotide binding]; DNA binding site
395491019153	RNA-binding motif; other site
395491019154	Response regulator receiver domain; Region: Response_reg; pfam00072
395491019155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491019156	active site
395491019157	phosphorylation site [posttranslational modification]
395491019158	intermolecular recognition site; other site
395491019159	dimerization interface [polypeptide binding]; other site
395491019160	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
395491019161	AhpC/TSA family; Region: AhpC-TSA; pfam00578
395491019162	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
395491019163	Predicted membrane protein [Function unknown]; Region: COG2259
395491019164	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
395491019165	hypothetical protein; Provisional; Region: PRK05409
395491019166	Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366
395491019167	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
395491019168	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
395491019169	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
395491019170	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
395491019171	homodimer interface [polypeptide binding]; other site
395491019172	active site
395491019173	TDP-binding site; other site
395491019174	acceptor substrate-binding pocket; other site
395491019175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216
395491019176	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
395491019177	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
395491019178	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
395491019179	Subunit I/III interface [polypeptide binding]; other site
395491019180	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
395491019181	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
395491019182	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
395491019183	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
395491019184	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395491019185	Cytochrome c; Region: Cytochrom_C; pfam00034
395491019186	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
395491019187	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
395491019188	Cu(I) binding site [ion binding]; other site
395491019189	Predicted membrane protein [Function unknown]; Region: COG4393
395491019190	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395491019191	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
395491019192	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
395491019193	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
395491019194	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
395491019195	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
395491019196	molybdopterin cofactor binding site; other site
395491019197	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
395491019198	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
395491019199	4Fe-4S binding domain; Region: Fer4; cl02805
395491019200	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
395491019201	heme-binding residues [chemical binding]; other site
395491019202	Bacterial SH3 domain; Region: SH3_4; pfam06347
395491019203	Bacterial SH3 domain; Region: SH3_4; pfam06347
395491019204	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
395491019205	MarR family; Region: MarR_2; pfam12802
395491019206	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395491019207	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395491019208	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
395491019209	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
395491019210	Trp docking motif [polypeptide binding]; other site
395491019211	putative active site [active]
395491019212	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395491019213	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
395491019214	putative ion selectivity filter; other site
395491019215	putative pore gating glutamate residue; other site
395491019216	putative H+/Cl- coupling transport residue; other site
395491019217	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395491019218	DNA-binding site [nucleotide binding]; DNA binding site
395491019219	RNA-binding motif; other site
395491019220	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
395491019221	putative metal binding site [ion binding]; other site
395491019222	Uncharacterized conserved protein [Function unknown]; Region: COG1432
395491019223	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
395491019224	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395491019225	FOG: CBS domain [General function prediction only]; Region: COG0517
395491019226	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
395491019227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
395491019228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
395491019229	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
395491019230	FeS/SAM binding site; other site
395491019231	DGQHR domain; Region: DGQHR; TIGR03187
395491019232	DNA-sulfur modification-associated; Region: DndB; cl17621
395491019233	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
395491019234	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
395491019235	ATP binding site [chemical binding]; other site
395491019236	putative Mg++ binding site [ion binding]; other site
395491019237	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395491019238	nucleotide binding region [chemical binding]; other site
395491019239	ATP-binding site [chemical binding]; other site
395491019240	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
395491019241	Family description; Region: UvrD_C_2; pfam13538
395491019242	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
395491019243	HTH DNA binding domain; Region: HTH_13; pfam11972
395491019244	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
395491019245	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744
395491019246	putative active site [active]
395491019247	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
395491019248	DNA binding site [nucleotide binding]
395491019249	dimer interface [polypeptide binding]; other site
395491019250	active site
395491019251	Int/Topo IB signature motif; other site
395491019252	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
395491019253	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
395491019254	putative active site [active]
395491019255	replication initiation protein RepC; Provisional; Region: PRK13824
395491019256	Replication protein C N-terminal domain; Region: RP-C; pfam03428
395491019257	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
395491019258	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
395491019259	ParB-like nuclease domain; Region: ParBc; pfam02195
395491019260	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
395491019261	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
395491019262	DNA binding residues [nucleotide binding]
395491019263	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491019264	P-loop; other site
395491019265	Magnesium ion binding site [ion binding]; other site
395491019266	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491019267	Magnesium ion binding site [ion binding]; other site
395491019268	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
395491019269	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491019270	active site
395491019271	motif I; other site
395491019272	motif II; other site
395491019273	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
395491019274	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395491019275	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491019276	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
395491019277	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
395491019278	putative ligand binding site [chemical binding]; other site
395491019279	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395491019280	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491019281	Walker A/P-loop; other site
395491019282	ATP binding site [chemical binding]; other site
395491019283	Q-loop/lid; other site
395491019284	ABC transporter signature motif; other site
395491019285	Walker B; other site
395491019286	D-loop; other site
395491019287	H-loop/switch region; other site
395491019288	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491019289	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491019290	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491019291	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491019292	TM-ABC transporter signature motif; other site
395491019293	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
395491019294	classical (c) SDRs; Region: SDR_c; cd05233
395491019295	NAD(P) binding site [chemical binding]; other site
395491019296	active site
395491019297	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491019298	classical (c) SDRs; Region: SDR_c; cd05233
395491019299	NAD(P) binding site [chemical binding]; other site
395491019300	active site
395491019301	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491019302	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
395491019303	dimer interface [polypeptide binding]; other site
395491019304	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491019305	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491019306	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491019307	HAMP domain; Region: HAMP; pfam00672
395491019308	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491019309	dimer interface [polypeptide binding]; other site
395491019310	phosphorylation site [posttranslational modification]
395491019311	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491019312	ATP binding site [chemical binding]; other site
395491019313	Mg2+ binding site [ion binding]; other site
395491019314	G-X-G motif; other site
395491019315	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491019316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491019317	active site
395491019318	phosphorylation site [posttranslational modification]
395491019319	intermolecular recognition site; other site
395491019320	dimerization interface [polypeptide binding]; other site
395491019321	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491019322	DNA binding site [nucleotide binding]
395491019323	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
395491019324	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
395491019325	aspartate kinase; Validated; Region: PRK09181
395491019326	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
395491019327	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
395491019328	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
395491019329	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
395491019330	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491019331	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491019332	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395491019333	putative effector binding pocket; other site
395491019334	putative dimerization interface [polypeptide binding]; other site
395491019335	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491019336	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491019337	active site
395491019338	catalytic tetrad [active]
395491019339	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
395491019340	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
395491019341	putative active site [active]
395491019342	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491019343	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
395491019344	Walker A/P-loop; other site
395491019345	ATP binding site [chemical binding]; other site
395491019346	Q-loop/lid; other site
395491019347	ABC transporter signature motif; other site
395491019348	Walker B; other site
395491019349	D-loop; other site
395491019350	H-loop/switch region; other site
395491019351	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
395491019352	HlyD family secretion protein; Region: HlyD_3; pfam13437
395491019353	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491019354	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395491019355	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
395491019356	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491019357	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491019358	non-specific DNA binding site [nucleotide binding]; other site
395491019359	salt bridge; other site
395491019360	sequence-specific DNA binding site [nucleotide binding]; other site
395491019361	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
395491019362	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
395491019363	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
395491019364	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395491019365	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395491019366	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491019367	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491019368	Walker A/P-loop; other site
395491019369	ATP binding site [chemical binding]; other site
395491019370	Q-loop/lid; other site
395491019371	ABC transporter signature motif; other site
395491019372	Walker B; other site
395491019373	D-loop; other site
395491019374	H-loop/switch region; other site
395491019375	TOBE domain; Region: TOBE_2; pfam08402
395491019376	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491019377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491019378	dimer interface [polypeptide binding]; other site
395491019379	conserved gate region; other site
395491019380	putative PBP binding loops; other site
395491019381	ABC-ATPase subunit interface; other site
395491019382	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
395491019383	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395491019384	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491019385	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491019386	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491019387	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491019388	DNA binding site [nucleotide binding]
395491019389	domain linker motif; other site
395491019390	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491019391	dimerization interface [polypeptide binding]; other site
395491019392	ligand binding site [chemical binding]; other site
395491019393	Predicted transcriptional regulator [Transcription]; Region: COG3905
395491019394	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
395491019395	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
395491019396	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395491019397	carboxyltransferase (CT) interaction site; other site
395491019398	biotinylation site [posttranslational modification]; other site
395491019399	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
395491019400	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395491019401	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395491019402	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
395491019403	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
395491019404	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
395491019405	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
395491019406	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
395491019407	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
395491019408	putative active site [active]
395491019409	aspartate aminotransferase; Provisional; Region: PRK05764
395491019410	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491019411	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491019412	homodimer interface [polypeptide binding]; other site
395491019413	catalytic residue [active]
395491019414	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
395491019415	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491019416	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
395491019417	putative dimerization interface [polypeptide binding]; other site
395491019418	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
395491019419	classical (c) SDRs; Region: SDR_c; cd05233
395491019420	NAD(P) binding site [chemical binding]; other site
395491019421	active site
395491019422	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491019423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491019424	dimer interface [polypeptide binding]; other site
395491019425	conserved gate region; other site
395491019426	putative PBP binding loops; other site
395491019427	ABC-ATPase subunit interface; other site
395491019428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491019429	dimer interface [polypeptide binding]; other site
395491019430	conserved gate region; other site
395491019431	putative PBP binding loops; other site
395491019432	ABC-ATPase subunit interface; other site
395491019433	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395491019434	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491019435	Walker A/P-loop; other site
395491019436	ATP binding site [chemical binding]; other site
395491019437	Q-loop/lid; other site
395491019438	ABC transporter signature motif; other site
395491019439	Walker B; other site
395491019440	D-loop; other site
395491019441	H-loop/switch region; other site
395491019442	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491019443	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491019444	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491019445	substrate binding pocket [chemical binding]; other site
395491019446	membrane-bound complex binding site; other site
395491019447	hinge residues; other site
395491019448	hypothetical protein; Validated; Region: PRK06201
395491019449	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
395491019450	Predicted deacylase [General function prediction only]; Region: COG3608
395491019451	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
395491019452	putative active site [active]
395491019453	Zn binding site [ion binding]; other site
395491019454	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
395491019455	homotrimer interaction site [polypeptide binding]; other site
395491019456	putative active site [active]
395491019457	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
395491019458	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
395491019459	dimer interface [polypeptide binding]; other site
395491019460	active site
395491019461	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395491019462	substrate binding site [chemical binding]; other site
395491019463	catalytic residue [active]
395491019464	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
395491019465	Amidohydrolase; Region: Amidohydro_2; pfam04909
395491019466	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491019467	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491019468	TM-ABC transporter signature motif; other site
395491019469	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491019470	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491019471	TM-ABC transporter signature motif; other site
395491019472	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491019473	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491019474	Walker A/P-loop; other site
395491019475	ATP binding site [chemical binding]; other site
395491019476	Q-loop/lid; other site
395491019477	ABC transporter signature motif; other site
395491019478	Walker B; other site
395491019479	D-loop; other site
395491019480	H-loop/switch region; other site
395491019481	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491019482	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
395491019483	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491019484	putative ligand binding site [chemical binding]; other site
395491019485	Transcriptional regulator [Transcription]; Region: IclR; COG1414
395491019486	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
395491019487	Bacterial transcriptional regulator; Region: IclR; pfam01614
395491019488	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395491019489	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395491019490	active site
395491019491	non-prolyl cis peptide bond; other site
395491019492	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491019493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491019494	dimer interface [polypeptide binding]; other site
395491019495	conserved gate region; other site
395491019496	putative PBP binding loops; other site
395491019497	ABC-ATPase subunit interface; other site
395491019498	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395491019499	NMT1/THI5 like; Region: NMT1; pfam09084
395491019500	substrate binding pocket [chemical binding]; other site
395491019501	membrane-bound complex binding site; other site
395491019502	hinge residues; other site
395491019503	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395491019504	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395491019505	Walker A/P-loop; other site
395491019506	ATP binding site [chemical binding]; other site
395491019507	Q-loop/lid; other site
395491019508	ABC transporter signature motif; other site
395491019509	Walker B; other site
395491019510	D-loop; other site
395491019511	H-loop/switch region; other site
395491019512	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395491019513	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
395491019514	Cl- selectivity filter; other site
395491019515	Cl- binding residues [ion binding]; other site
395491019516	pore gating glutamate residue; other site
395491019517	dimer interface [polypeptide binding]; other site
395491019518	FOG: CBS domain [General function prediction only]; Region: COG0517
395491019519	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
395491019520	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395491019521	MarR family; Region: MarR_2; pfam12802
395491019522	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
395491019523	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491019524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491019525	dimer interface [polypeptide binding]; other site
395491019526	conserved gate region; other site
395491019527	putative PBP binding loops; other site
395491019528	ABC-ATPase subunit interface; other site
395491019529	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491019530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491019531	dimer interface [polypeptide binding]; other site
395491019532	ABC-ATPase subunit interface; other site
395491019533	putative PBP binding loops; other site
395491019534	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491019535	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491019536	substrate binding pocket [chemical binding]; other site
395491019537	membrane-bound complex binding site; other site
395491019538	hinge residues; other site
395491019539	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
395491019540	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491019541	Walker A/P-loop; other site
395491019542	ATP binding site [chemical binding]; other site
395491019543	Q-loop/lid; other site
395491019544	ABC transporter signature motif; other site
395491019545	Walker B; other site
395491019546	D-loop; other site
395491019547	H-loop/switch region; other site
395491019548	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395491019549	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491019550	putative DNA binding site [nucleotide binding]; other site
395491019551	putative Zn2+ binding site [ion binding]; other site
395491019552	AsnC family; Region: AsnC_trans_reg; pfam01037
395491019553	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
395491019554	Cache domain; Region: Cache_2; pfam08269
395491019555	Histidine kinase; Region: HisKA_3; pfam07730
395491019556	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
395491019557	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395491019558	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491019559	active site
395491019560	phosphorylation site [posttranslational modification]
395491019561	intermolecular recognition site; other site
395491019562	dimerization interface [polypeptide binding]; other site
395491019563	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491019564	DNA binding residues [nucleotide binding]
395491019565	dimerization interface [polypeptide binding]; other site
395491019566	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
395491019567	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
395491019568	Na binding site [ion binding]; other site
395491019569	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
395491019570	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395491019571	dimerization interface [polypeptide binding]; other site
395491019572	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395491019573	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491019574	dimer interface [polypeptide binding]; other site
395491019575	putative CheW interface [polypeptide binding]; other site
395491019576	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
395491019577	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
395491019578	active site
395491019579	dimer interface [polypeptide binding]; other site
395491019580	non-prolyl cis peptide bond; other site
395491019581	insertion regions; other site
395491019582	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395491019583	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395491019584	active site
395491019585	non-prolyl cis peptide bond; other site
395491019586	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395491019587	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395491019588	Walker A/P-loop; other site
395491019589	ATP binding site [chemical binding]; other site
395491019590	Q-loop/lid; other site
395491019591	ABC transporter signature motif; other site
395491019592	Walker B; other site
395491019593	D-loop; other site
395491019594	H-loop/switch region; other site
395491019595	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491019596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395491019597	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395491019598	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395491019599	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315
395491019600	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395491019601	putative ligand binding site [chemical binding]; other site
395491019602	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491019603	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491019604	TM-ABC transporter signature motif; other site
395491019605	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491019606	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491019607	Walker A/P-loop; other site
395491019608	ATP binding site [chemical binding]; other site
395491019609	Q-loop/lid; other site
395491019610	ABC transporter signature motif; other site
395491019611	Walker B; other site
395491019612	D-loop; other site
395491019613	H-loop/switch region; other site
395491019614	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491019615	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395491019616	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
395491019617	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
395491019618	AAA domain; Region: AAA_33; pfam13671
395491019619	ATP-binding site [chemical binding]; other site
395491019620	Gluconate-6-phosphate binding site [chemical binding]; other site
395491019621	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
395491019622	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
395491019623	NADP binding site [chemical binding]; other site
395491019624	homodimer interface [polypeptide binding]; other site
395491019625	active site
395491019626	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
395491019627	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
395491019628	putative ligand binding site [chemical binding]; other site
395491019629	NAD binding site [chemical binding]; other site
395491019630	catalytic site [active]
395491019631	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
395491019632	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
395491019633	putative NAD(P) binding site [chemical binding]; other site
395491019634	catalytic Zn binding site [ion binding]; other site
395491019635	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491019636	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491019637	DNA binding site [nucleotide binding]
395491019638	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
395491019639	putative dimerization interface [polypeptide binding]; other site
395491019640	putative ligand binding site [chemical binding]; other site
395491019641	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
395491019642	Strictosidine synthase; Region: Str_synth; pfam03088
395491019643	von Willebrand factor; Region: vWF_A; pfam12450
395491019644	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
395491019645	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
395491019646	metal ion-dependent adhesion site (MIDAS); other site
395491019647	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
395491019648	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
395491019649	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491019650	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491019651	DNA binding residues [nucleotide binding]
395491019652	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
395491019653	Predicted acyl esterases [General function prediction only]; Region: COG2936
395491019654	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395491019655	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
395491019656	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395491019657	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491019658	Walker A/P-loop; other site
395491019659	ATP binding site [chemical binding]; other site
395491019660	Q-loop/lid; other site
395491019661	ABC transporter signature motif; other site
395491019662	Walker B; other site
395491019663	D-loop; other site
395491019664	H-loop/switch region; other site
395491019665	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491019666	Walker A/P-loop; other site
395491019667	ATP binding site [chemical binding]; other site
395491019668	Q-loop/lid; other site
395491019669	ABC transporter signature motif; other site
395491019670	Walker B; other site
395491019671	D-loop; other site
395491019672	H-loop/switch region; other site
395491019673	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491019674	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491019675	dimer interface [polypeptide binding]; other site
395491019676	conserved gate region; other site
395491019677	ABC-ATPase subunit interface; other site
395491019678	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491019679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491019680	dimer interface [polypeptide binding]; other site
395491019681	conserved gate region; other site
395491019682	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
395491019683	ABC-ATPase subunit interface; other site
395491019684	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491019685	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
395491019686	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
395491019687	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395491019688	substrate binding site [chemical binding]; other site
395491019689	oxyanion hole (OAH) forming residues; other site
395491019690	trimer interface [polypeptide binding]; other site
395491019691	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
395491019692	CoA binding domain; Region: CoA_binding_2; pfam13380
395491019693	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
395491019694	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
395491019695	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395491019696	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395491019697	active site
395491019698	bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531
395491019699	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
395491019700	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395491019701	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
395491019702	active site
395491019703	Uncharacterized conserved protein [Function unknown]; Region: COG3246
395491019704	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395491019705	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
395491019706	conserved cys residue [active]
395491019707	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491019708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491019709	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491019710	dimerization interface [polypeptide binding]; other site
395491019711	EamA-like transporter family; Region: EamA; pfam00892
395491019712	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
395491019713	EamA-like transporter family; Region: EamA; pfam00892
395491019714	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
395491019715	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
395491019716	NAD binding site [chemical binding]; other site
395491019717	catalytic Zn binding site [ion binding]; other site
395491019718	structural Zn binding site [ion binding]; other site
395491019719	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491019720	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491019721	substrate binding pocket [chemical binding]; other site
395491019722	membrane-bound complex binding site; other site
395491019723	hinge residues; other site
395491019724	CHASE4 domain; Region: CHASE4; cl01308
395491019725	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491019726	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491019727	metal binding site [ion binding]; metal-binding site
395491019728	active site
395491019729	I-site; other site
395491019730	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491019731	Isochorismatase family; Region: Isochorismatase; pfam00857
395491019732	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
395491019733	catalytic triad [active]
395491019734	conserved cis-peptide bond; other site
395491019735	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
395491019736	agmatinase; Region: agmatinase; TIGR01230
395491019737	oligomer interface [polypeptide binding]; other site
395491019738	putative active site [active]
395491019739	Mn binding site [ion binding]; other site
395491019740	hypothetical protein; Provisional; Region: PRK07550
395491019741	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395491019742	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491019743	homodimer interface [polypeptide binding]; other site
395491019744	catalytic residue [active]
395491019745	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
395491019746	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395491019747	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395491019748	active site
395491019749	non-prolyl cis peptide bond; other site
395491019750	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491019751	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491019752	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491019753	dimerization interface [polypeptide binding]; other site
395491019754	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
395491019755	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491019756	DNA-binding site [nucleotide binding]; DNA binding site
395491019757	UTRA domain; Region: UTRA; pfam07702
395491019758	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491019759	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491019760	substrate binding pocket [chemical binding]; other site
395491019761	membrane-bound complex binding site; other site
395491019762	hinge residues; other site
395491019763	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491019764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491019765	dimer interface [polypeptide binding]; other site
395491019766	conserved gate region; other site
395491019767	putative PBP binding loops; other site
395491019768	ABC-ATPase subunit interface; other site
395491019769	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491019770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491019771	dimer interface [polypeptide binding]; other site
395491019772	conserved gate region; other site
395491019773	putative PBP binding loops; other site
395491019774	ABC-ATPase subunit interface; other site
395491019775	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395491019776	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491019777	Walker A/P-loop; other site
395491019778	ATP binding site [chemical binding]; other site
395491019779	Q-loop/lid; other site
395491019780	ABC transporter signature motif; other site
395491019781	Walker B; other site
395491019782	D-loop; other site
395491019783	H-loop/switch region; other site
395491019784	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
395491019785	Isochorismatase family; Region: Isochorismatase; pfam00857
395491019786	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
395491019787	catalytic triad [active]
395491019788	conserved cis-peptide bond; other site
395491019789	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
395491019790	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491019791	Walker A/P-loop; other site
395491019792	ATP binding site [chemical binding]; other site
395491019793	Q-loop/lid; other site
395491019794	ABC transporter signature motif; other site
395491019795	Walker B; other site
395491019796	D-loop; other site
395491019797	H-loop/switch region; other site
395491019798	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491019799	Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663
395491019800	Isochorismatase family; Region: Isochorismatase; pfam00857
395491019801	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
395491019802	catalytic triad [active]
395491019803	conserved cis-peptide bond; other site
395491019804	formamidase; Provisional; Region: amiF; PRK13287
395491019805	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
395491019806	multimer interface [polypeptide binding]; other site
395491019807	active site
395491019808	catalytic triad [active]
395491019809	dimer interface [polypeptide binding]; other site
395491019810	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491019811	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
395491019812	TM-ABC transporter signature motif; other site
395491019813	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
395491019814	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491019815	TM-ABC transporter signature motif; other site
395491019816	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
395491019817	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
395491019818	putative ligand binding site [chemical binding]; other site
395491019819	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491019820	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491019821	DNA-binding site [nucleotide binding]; DNA binding site
395491019822	FCD domain; Region: FCD; pfam07729
395491019823	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395491019824	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395491019825	Walker A/P-loop; other site
395491019826	ATP binding site [chemical binding]; other site
395491019827	Q-loop/lid; other site
395491019828	ABC transporter signature motif; other site
395491019829	Walker B; other site
395491019830	D-loop; other site
395491019831	H-loop/switch region; other site
395491019832	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395491019833	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491019834	putative PBP binding loops; other site
395491019835	dimer interface [polypeptide binding]; other site
395491019836	ABC-ATPase subunit interface; other site
395491019837	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395491019838	NMT1-like family; Region: NMT1_2; pfam13379
395491019839	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
395491019840	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491019841	TM-ABC transporter signature motif; other site
395491019842	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491019843	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
395491019844	TM-ABC transporter signature motif; other site
395491019845	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
395491019846	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491019847	Walker A/P-loop; other site
395491019848	ATP binding site [chemical binding]; other site
395491019849	Q-loop/lid; other site
395491019850	ABC transporter signature motif; other site
395491019851	Walker B; other site
395491019852	D-loop; other site
395491019853	H-loop/switch region; other site
395491019854	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491019855	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
395491019856	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
395491019857	putative ligand binding site [chemical binding]; other site
395491019858	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
395491019859	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
395491019860	active site
395491019861	putative substrate binding pocket [chemical binding]; other site
395491019862	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395491019863	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
395491019864	putative C-terminal domain interface [polypeptide binding]; other site
395491019865	putative GSH binding site (G-site) [chemical binding]; other site
395491019866	putative dimer interface [polypeptide binding]; other site
395491019867	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395491019868	N-terminal domain interface [polypeptide binding]; other site
395491019869	dimer interface [polypeptide binding]; other site
395491019870	substrate binding pocket (H-site) [chemical binding]; other site
395491019871	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
395491019872	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
395491019873	hydrophobic ligand binding site; other site
395491019874	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
395491019875	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
395491019876	[2Fe-2S] cluster binding site [ion binding]; other site
395491019877	Acylphosphatase; Region: Acylphosphatase; cl00551
395491019878	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491019879	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491019880	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395491019881	putative effector binding pocket; other site
395491019882	dimerization interface [polypeptide binding]; other site
395491019883	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
395491019884	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
395491019885	catalytic residues [active]
395491019886	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395491019887	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
395491019888	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
395491019889	Walker A/P-loop; other site
395491019890	ATP binding site [chemical binding]; other site
395491019891	Q-loop/lid; other site
395491019892	ABC transporter signature motif; other site
395491019893	Walker B; other site
395491019894	D-loop; other site
395491019895	H-loop/switch region; other site
395491019896	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
395491019897	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
395491019898	siderophore binding site; other site
395491019899	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
395491019900	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491019901	ABC-ATPase subunit  interface; other site
395491019902	dimer interface [polypeptide binding]; other site
395491019903	putative PBP binding regions; other site
395491019904	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491019905	ABC-ATPase subunit  interface; other site
395491019906	dimer interface [polypeptide binding]; other site
395491019907	putative PBP binding regions; other site
395491019908	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
395491019909	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
395491019910	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
395491019911	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
395491019912	PhnA protein; Region: PhnA; pfam03831
395491019913	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
395491019914	Fic/DOC family; Region: Fic; pfam02661
395491019915	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395491019916	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
395491019917	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
395491019918	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
395491019919	UbiA prenyltransferase family; Region: UbiA; pfam01040
395491019920	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
395491019921	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491019922	motif II; other site
395491019923	Predicted membrane protein [Function unknown]; Region: COG2246
395491019924	GtrA-like protein; Region: GtrA; pfam04138
395491019925	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
395491019926	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395491019927	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395491019928	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
395491019929	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395491019930	E3 interaction surface; other site
395491019931	lipoyl attachment site [posttranslational modification]; other site
395491019932	e3 binding domain; Region: E3_binding; pfam02817
395491019933	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
395491019934	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
395491019935	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
395491019936	alpha subunit interface [polypeptide binding]; other site
395491019937	TPP binding site [chemical binding]; other site
395491019938	heterodimer interface [polypeptide binding]; other site
395491019939	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395491019940	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
395491019941	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
395491019942	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
395491019943	tetramer interface [polypeptide binding]; other site
395491019944	TPP-binding site [chemical binding]; other site
395491019945	heterodimer interface [polypeptide binding]; other site
395491019946	phosphorylation loop region [posttranslational modification]
395491019947	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395491019948	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395491019949	active site
395491019950	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
395491019951	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
395491019952	dimer interface [polypeptide binding]; other site
395491019953	active site
395491019954	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
395491019955	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
395491019956	NAD binding site [chemical binding]; other site
395491019957	homodimer interface [polypeptide binding]; other site
395491019958	homotetramer interface [polypeptide binding]; other site
395491019959	active site
395491019960	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
395491019961	SurA N-terminal domain; Region: SurA_N; pfam09312
395491019962	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491019963	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491019964	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
395491019965	isovaleryl-CoA dehydrogenase; Region: PLN02519
395491019966	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
395491019967	substrate binding site [chemical binding]; other site
395491019968	FAD binding site [chemical binding]; other site
395491019969	catalytic base [active]
395491019970	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
395491019971	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
395491019972	substrate binding site [chemical binding]; other site
395491019973	oxyanion hole (OAH) forming residues; other site
395491019974	trimer interface [polypeptide binding]; other site
395491019975	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
395491019976	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
395491019977	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395491019978	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395491019979	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
395491019980	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395491019981	carboxyltransferase (CT) interaction site; other site
395491019982	biotinylation site [posttranslational modification]; other site
395491019983	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
395491019984	putative active site [active]
395491019985	putative catalytic site [active]
395491019986	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
395491019987	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
395491019988	HAMP domain; Region: HAMP; pfam00672
395491019989	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491019990	dimer interface [polypeptide binding]; other site
395491019991	phosphorylation site [posttranslational modification]
395491019992	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491019993	ATP binding site [chemical binding]; other site
395491019994	Mg2+ binding site [ion binding]; other site
395491019995	G-X-G motif; other site
395491019996	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
395491019997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491019998	active site
395491019999	phosphorylation site [posttranslational modification]
395491020000	intermolecular recognition site; other site
395491020001	dimerization interface [polypeptide binding]; other site
395491020002	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491020003	DNA binding site [nucleotide binding]
395491020004	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
395491020005	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
395491020006	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
395491020007	active site
395491020008	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
395491020009	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491020010	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491020011	DNA-binding site [nucleotide binding]; DNA binding site
395491020012	FCD domain; Region: FCD; pfam07729
395491020013	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395491020014	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
395491020015	inhibitor site; inhibition site
395491020016	active site
395491020017	dimer interface [polypeptide binding]; other site
395491020018	catalytic residue [active]
395491020019	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491020020	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491020021	Walker A/P-loop; other site
395491020022	ATP binding site [chemical binding]; other site
395491020023	Q-loop/lid; other site
395491020024	ABC transporter signature motif; other site
395491020025	Walker B; other site
395491020026	D-loop; other site
395491020027	H-loop/switch region; other site
395491020028	TOBE domain; Region: TOBE; pfam03459
395491020029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
395491020030	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
395491020031	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491020032	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020033	dimer interface [polypeptide binding]; other site
395491020034	conserved gate region; other site
395491020035	putative PBP binding loops; other site
395491020036	ABC-ATPase subunit interface; other site
395491020037	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020038	dimer interface [polypeptide binding]; other site
395491020039	conserved gate region; other site
395491020040	putative PBP binding loops; other site
395491020041	ABC-ATPase subunit interface; other site
395491020042	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491020043	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491020044	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491020045	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491020046	DNA binding site [nucleotide binding]
395491020047	domain linker motif; other site
395491020048	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491020049	ligand binding site [chemical binding]; other site
395491020050	dimerization interface [polypeptide binding]; other site
395491020051	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491020052	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491020053	DNA binding site [nucleotide binding]
395491020054	domain linker motif; other site
395491020055	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395491020056	dimerization interface [polypeptide binding]; other site
395491020057	ligand binding site [chemical binding]; other site
395491020058	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
395491020059	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
395491020060	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491020061	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491020062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020063	dimer interface [polypeptide binding]; other site
395491020064	conserved gate region; other site
395491020065	putative PBP binding loops; other site
395491020066	ABC-ATPase subunit interface; other site
395491020067	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491020068	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020069	dimer interface [polypeptide binding]; other site
395491020070	conserved gate region; other site
395491020071	putative PBP binding loops; other site
395491020072	ABC-ATPase subunit interface; other site
395491020073	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491020074	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491020075	Walker A/P-loop; other site
395491020076	ATP binding site [chemical binding]; other site
395491020077	Q-loop/lid; other site
395491020078	ABC transporter signature motif; other site
395491020079	Walker B; other site
395491020080	D-loop; other site
395491020081	H-loop/switch region; other site
395491020082	TOBE domain; Region: TOBE_2; pfam08402
395491020083	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
395491020084	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395491020085	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395491020086	membrane-bound complex binding site; other site
395491020087	hinge residues; other site
395491020088	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
395491020089	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
395491020090	tetramerization interface [polypeptide binding]; other site
395491020091	NAD(P) binding site [chemical binding]; other site
395491020092	catalytic residues [active]
395491020093	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395491020094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491020095	Walker A/P-loop; other site
395491020096	ATP binding site [chemical binding]; other site
395491020097	Q-loop/lid; other site
395491020098	ABC transporter signature motif; other site
395491020099	Walker B; other site
395491020100	D-loop; other site
395491020101	H-loop/switch region; other site
395491020102	TOBE domain; Region: TOBE_2; pfam08402
395491020103	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395491020104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020105	putative PBP binding loops; other site
395491020106	ABC-ATPase subunit interface; other site
395491020107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020108	dimer interface [polypeptide binding]; other site
395491020109	conserved gate region; other site
395491020110	putative PBP binding loops; other site
395491020111	ABC-ATPase subunit interface; other site
395491020112	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
395491020113	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491020114	NIPSNAP; Region: NIPSNAP; pfam07978
395491020115	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395491020116	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
395491020117	NAD(P) binding site [chemical binding]; other site
395491020118	catalytic residues [active]
395491020119	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
395491020120	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
395491020121	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
395491020122	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
395491020123	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491020124	Amino acid synthesis; Region: AA_synth; pfam06684
395491020125	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491020126	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491020127	DNA-binding site [nucleotide binding]; DNA binding site
395491020128	FCD domain; Region: FCD; pfam07729
395491020129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
395491020130	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
395491020131	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
395491020132	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
395491020133	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
395491020134	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
395491020135	MobA/MobL family; Region: MobA_MobL; pfam03389
395491020136	AAA domain; Region: AAA_30; pfam13604
395491020137	Family description; Region: UvrD_C_2; pfam13538
395491020138	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
395491020139	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395491020140	Walker A motif; other site
395491020141	ATP binding site [chemical binding]; other site
395491020142	Walker B motif; other site
395491020143	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
395491020144	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
395491020145	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
395491020146	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491020147	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491020148	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
395491020149	dimerization interface [polypeptide binding]; other site
395491020150	substrate binding pocket [chemical binding]; other site
395491020151	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491020152	non-specific DNA binding site [nucleotide binding]; other site
395491020153	salt bridge; other site
395491020154	sequence-specific DNA binding site [nucleotide binding]; other site
395491020155	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
395491020156	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395491020157	Lysozyme family protein [General function prediction only]; Region: COG5526
395491020158	Peptidase M15; Region: Peptidase_M15_3; cl01194
395491020159	Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain; Region: NMT; pfam01233
395491020160	Caspase domain; Region: Peptidase_C14; pfam00656
395491020161	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395491020162	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
395491020163	structural tetrad; other site
395491020164	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
395491020165	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491020166	non-specific DNA binding site [nucleotide binding]; other site
395491020167	salt bridge; other site
395491020168	sequence-specific DNA binding site [nucleotide binding]; other site
395491020169	Cupin domain; Region: Cupin_2; pfam07883
395491020170	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
395491020171	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
395491020172	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
395491020173	putative active site [active]
395491020174	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
395491020175	domain_subunit interface; other site
395491020176	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
395491020177	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
395491020178	active site
395491020179	FMN binding site [chemical binding]; other site
395491020180	substrate binding site [chemical binding]; other site
395491020181	3Fe-4S cluster binding site [ion binding]; other site
395491020182	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
395491020183	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395491020184	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
395491020185	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
395491020186	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
395491020187	putative active site [active]
395491020188	putative substrate binding site [chemical binding]; other site
395491020189	putative cosubstrate binding site; other site
395491020190	catalytic site [active]
395491020191	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
395491020192	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395491020193	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
395491020194	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
395491020195	FMN-binding pocket [chemical binding]; other site
395491020196	flavin binding motif; other site
395491020197	phosphate binding motif [ion binding]; other site
395491020198	beta-alpha-beta structure motif; other site
395491020199	NAD binding pocket [chemical binding]; other site
395491020200	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395491020201	catalytic loop [active]
395491020202	iron binding site [ion binding]; other site
395491020203	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
395491020204	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
395491020205	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395491020206	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491020207	PAS fold; Region: PAS_3; pfam08447
395491020208	putative active site [active]
395491020209	heme pocket [chemical binding]; other site
395491020210	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395491020211	putative CheW interface [polypeptide binding]; other site
395491020212	septum formation inhibitor; Reviewed; Region: minC; PRK05177
395491020213	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
395491020214	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
395491020215	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
395491020216	Switch I; other site
395491020217	Switch II; other site
395491020218	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
395491020219	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395491020220	DNA-binding site [nucleotide binding]; DNA binding site
395491020221	RNA-binding motif; other site
395491020222	Uncharacterized conserved protein [Function unknown]; Region: COG3665
395491020223	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
395491020224	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395491020225	Amino acid permease; Region: AA_permease_2; pfam13520
395491020226	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395491020227	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395491020228	active site
395491020229	catalytic tetrad [active]
395491020230	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
395491020231	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395491020232	MarR family; Region: MarR_2; pfam12802
395491020233	haloalkane dehalogenase; Provisional; Region: PRK03592
395491020234	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
395491020235	RNA binding site [nucleotide binding]; other site
395491020236	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491020237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491020238	active site
395491020239	phosphorylation site [posttranslational modification]
395491020240	intermolecular recognition site; other site
395491020241	dimerization interface [polypeptide binding]; other site
395491020242	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491020243	DNA binding site [nucleotide binding]
395491020244	Src Homology 3 domain superfamily; Region: SH3; cl17036
395491020245	peptide ligand binding site [polypeptide binding]; other site
395491020246	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491020247	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491020248	dimer interface [polypeptide binding]; other site
395491020249	phosphorylation site [posttranslational modification]
395491020250	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491020251	ATP binding site [chemical binding]; other site
395491020252	Mg2+ binding site [ion binding]; other site
395491020253	G-X-G motif; other site
395491020254	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
395491020255	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
395491020256	active site
395491020257	catalytic site [active]
395491020258	substrate binding site [chemical binding]; other site
395491020259	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
395491020260	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
395491020261	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
395491020262	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
395491020263	NADP binding site [chemical binding]; other site
395491020264	homodimer interface [polypeptide binding]; other site
395491020265	active site
395491020266	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491020267	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491020268	DNA-binding site [nucleotide binding]; DNA binding site
395491020269	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
395491020270	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
395491020271	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
395491020272	active site
395491020273	catalytic site [active]
395491020274	substrate binding site [chemical binding]; other site
395491020275	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
395491020276	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491020277	putative substrate translocation pore; other site
395491020278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491020279	flagellin; Reviewed; Region: PRK12687
395491020280	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395491020281	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395491020282	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
395491020283	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
395491020284	active site
395491020285	Predicted transcriptional regulators [Transcription]; Region: COG1733
395491020286	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395491020287	short chain dehydrogenase; Provisional; Region: PRK06179
395491020288	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395491020289	NADP binding site [chemical binding]; other site
395491020290	active site
395491020291	steroid binding site; other site
395491020292	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395491020293	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
395491020294	putative NAD(P) binding site [chemical binding]; other site
395491020295	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491020296	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491020297	EamA-like transporter family; Region: EamA; pfam00892
395491020298	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395491020299	non-specific DNA interactions [nucleotide binding]; other site
395491020300	DNA binding site [nucleotide binding]
395491020301	sequence specific DNA binding site [nucleotide binding]; other site
395491020302	putative cAMP binding site [chemical binding]; other site
395491020303	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395491020304	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
395491020305	nucleotide binding site [chemical binding]; other site
395491020306	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395491020307	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491020308	sugar efflux transporter; Region: 2A0120; TIGR00899
395491020309	putative substrate translocation pore; other site
395491020310	short chain dehydrogenase; Provisional; Region: PRK07074
395491020311	classical (c) SDRs; Region: SDR_c; cd05233
395491020312	NAD(P) binding site [chemical binding]; other site
395491020313	active site
395491020314	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
395491020315	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
395491020316	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
395491020317	putative active site [active]
395491020318	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
395491020319	homotrimer interaction site [polypeptide binding]; other site
395491020320	putative active site [active]
395491020321	Uncharacterized conserved protein [Function unknown]; Region: COG5476
395491020322	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
395491020323	MlrC C-terminus; Region: MlrC_C; pfam07171
395491020324	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
395491020325	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
395491020326	dimer interface [polypeptide binding]; other site
395491020327	active site
395491020328	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395491020329	substrate binding site [chemical binding]; other site
395491020330	catalytic residue [active]
395491020331	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491020332	cyclase homology domain; Region: CHD; cd07302
395491020333	nucleotidyl binding site; other site
395491020334	metal binding site [ion binding]; metal-binding site
395491020335	dimer interface [polypeptide binding]; other site
395491020336	Predicted integral membrane protein [Function unknown]; Region: COG5616
395491020337	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395491020338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491020339	TPR motif; other site
395491020340	binding surface
395491020341	TPR repeat; Region: TPR_11; pfam13414
395491020342	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491020343	TPR motif; other site
395491020344	binding surface
395491020345	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491020346	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491020347	Walker A/P-loop; other site
395491020348	ATP binding site [chemical binding]; other site
395491020349	Q-loop/lid; other site
395491020350	ABC transporter signature motif; other site
395491020351	Walker B; other site
395491020352	D-loop; other site
395491020353	H-loop/switch region; other site
395491020354	TOBE domain; Region: TOBE_2; pfam08402
395491020355	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395491020356	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395491020357	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491020358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020359	dimer interface [polypeptide binding]; other site
395491020360	conserved gate region; other site
395491020361	ABC-ATPase subunit interface; other site
395491020362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020363	dimer interface [polypeptide binding]; other site
395491020364	conserved gate region; other site
395491020365	putative PBP binding loops; other site
395491020366	ABC-ATPase subunit interface; other site
395491020367	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491020368	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491020369	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491020370	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
395491020371	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
395491020372	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491020373	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491020374	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491020375	dimerization interface [polypeptide binding]; other site
395491020376	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491020377	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491020378	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
395491020379	putative dimerization interface [polypeptide binding]; other site
395491020380	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491020381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020382	dimer interface [polypeptide binding]; other site
395491020383	conserved gate region; other site
395491020384	putative PBP binding loops; other site
395491020385	ABC-ATPase subunit interface; other site
395491020386	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
395491020387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020388	dimer interface [polypeptide binding]; other site
395491020389	conserved gate region; other site
395491020390	putative PBP binding loops; other site
395491020391	ABC-ATPase subunit interface; other site
395491020392	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395491020393	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491020394	Walker A/P-loop; other site
395491020395	ATP binding site [chemical binding]; other site
395491020396	Q-loop/lid; other site
395491020397	ABC transporter signature motif; other site
395491020398	Walker B; other site
395491020399	D-loop; other site
395491020400	H-loop/switch region; other site
395491020401	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491020402	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491020403	Walker A/P-loop; other site
395491020404	ATP binding site [chemical binding]; other site
395491020405	Q-loop/lid; other site
395491020406	ABC transporter signature motif; other site
395491020407	Walker B; other site
395491020408	D-loop; other site
395491020409	H-loop/switch region; other site
395491020410	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491020411	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
395491020412	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
395491020413	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491020414	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
395491020415	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
395491020416	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
395491020417	putative metal binding site [ion binding]; other site
395491020418	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395491020419	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
395491020420	ligand binding site [chemical binding]; other site
395491020421	regulator interaction site; other site
395491020422	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
395491020423	ANTAR domain; Region: ANTAR; pfam03861
395491020424	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580
395491020425	Predicted amidohydrolase [General function prediction only]; Region: COG0388
395491020426	putative active site [active]
395491020427	catalytic triad [active]
395491020428	putative dimer interface [polypeptide binding]; other site
395491020429	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395491020430	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
395491020431	putative ligand binding site [chemical binding]; other site
395491020432	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491020433	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395491020434	TM-ABC transporter signature motif; other site
395491020435	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395491020436	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395491020437	TM-ABC transporter signature motif; other site
395491020438	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395491020439	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395491020440	Walker A/P-loop; other site
395491020441	ATP binding site [chemical binding]; other site
395491020442	Q-loop/lid; other site
395491020443	ABC transporter signature motif; other site
395491020444	Walker B; other site
395491020445	D-loop; other site
395491020446	H-loop/switch region; other site
395491020447	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
395491020448	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395491020449	Walker A/P-loop; other site
395491020450	ATP binding site [chemical binding]; other site
395491020451	Q-loop/lid; other site
395491020452	ABC transporter signature motif; other site
395491020453	Walker B; other site
395491020454	D-loop; other site
395491020455	H-loop/switch region; other site
395491020456	Amidase; Region: Amidase; cl11426
395491020457	indole-3-acetamide amidohydrolase; Region: PLN02722
395491020458	Protein of unknown function, DUF606; Region: DUF606; pfam04657
395491020459	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
395491020460	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
395491020461	active site
395491020462	SUMO-1 interface [polypeptide binding]; other site
395491020463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
395491020464	MOSC domain; Region: MOSC; pfam03473
395491020465	3-alpha domain; Region: 3-alpha; pfam03475
395491020466	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
395491020467	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
395491020468	FAD binding pocket [chemical binding]; other site
395491020469	FAD binding motif [chemical binding]; other site
395491020470	phosphate binding motif [ion binding]; other site
395491020471	beta-alpha-beta structure motif; other site
395491020472	NAD binding pocket [chemical binding]; other site
395491020473	Heme binding  pocket [chemical binding]; other site
395491020474	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395491020475	catalytic loop [active]
395491020476	iron binding site [ion binding]; other site
395491020477	Pirin; Region: Pirin; pfam02678
395491020478	Pirin-related protein [General function prediction only]; Region: COG1741
395491020479	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
395491020480	TIGR02588 family protein; Region: TIGR02588
395491020481	Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622
395491020482	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
395491020483	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
395491020484	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
395491020485	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395491020486	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395491020487	hypothetical protein; Provisional; Region: PRK11171
395491020488	Cupin domain; Region: Cupin_2; pfam07883
395491020489	Cupin domain; Region: Cupin_2; pfam07883
395491020490	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395491020491	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491020492	Walker A/P-loop; other site
395491020493	ATP binding site [chemical binding]; other site
395491020494	Q-loop/lid; other site
395491020495	ABC transporter signature motif; other site
395491020496	Walker B; other site
395491020497	D-loop; other site
395491020498	H-loop/switch region; other site
395491020499	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
395491020500	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491020501	Walker A/P-loop; other site
395491020502	ATP binding site [chemical binding]; other site
395491020503	Q-loop/lid; other site
395491020504	ABC transporter signature motif; other site
395491020505	Walker B; other site
395491020506	D-loop; other site
395491020507	H-loop/switch region; other site
395491020508	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
395491020509	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
395491020510	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
395491020511	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395491020512	catalytic residue [active]
395491020513	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
395491020514	homotrimer interaction site [polypeptide binding]; other site
395491020515	putative active site [active]
395491020516	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491020517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020518	dimer interface [polypeptide binding]; other site
395491020519	conserved gate region; other site
395491020520	putative PBP binding loops; other site
395491020521	ABC-ATPase subunit interface; other site
395491020522	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491020523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020524	dimer interface [polypeptide binding]; other site
395491020525	conserved gate region; other site
395491020526	putative PBP binding loops; other site
395491020527	ABC-ATPase subunit interface; other site
395491020528	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491020529	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
395491020530	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
395491020531	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395491020532	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
395491020533	ligand binding site [chemical binding]; other site
395491020534	regulator interaction site; other site
395491020535	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
395491020536	ANTAR domain; Region: ANTAR; pfam03861
395491020537	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491020538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020539	dimer interface [polypeptide binding]; other site
395491020540	conserved gate region; other site
395491020541	putative PBP binding loops; other site
395491020542	ABC-ATPase subunit interface; other site
395491020543	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491020544	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020545	dimer interface [polypeptide binding]; other site
395491020546	conserved gate region; other site
395491020547	putative PBP binding loops; other site
395491020548	ABC-ATPase subunit interface; other site
395491020549	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491020550	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
395491020551	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
395491020552	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395491020553	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491020554	Walker A/P-loop; other site
395491020555	ATP binding site [chemical binding]; other site
395491020556	Q-loop/lid; other site
395491020557	ABC transporter signature motif; other site
395491020558	Walker B; other site
395491020559	D-loop; other site
395491020560	H-loop/switch region; other site
395491020561	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491020562	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491020563	Walker A/P-loop; other site
395491020564	ATP binding site [chemical binding]; other site
395491020565	Q-loop/lid; other site
395491020566	ABC transporter signature motif; other site
395491020567	Walker B; other site
395491020568	D-loop; other site
395491020569	H-loop/switch region; other site
395491020570	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491020571	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
395491020572	substrate binding site [chemical binding]; other site
395491020573	multimerization interface [polypeptide binding]; other site
395491020574	ATP binding site [chemical binding]; other site
395491020575	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
395491020576	thiamine phosphate binding site [chemical binding]; other site
395491020577	active site
395491020578	pyrophosphate binding site [ion binding]; other site
395491020579	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
395491020580	dimer interface [polypeptide binding]; other site
395491020581	substrate binding site [chemical binding]; other site
395491020582	ATP binding site [chemical binding]; other site
395491020583	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395491020584	Coenzyme A binding pocket [chemical binding]; other site
395491020585	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
395491020586	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
395491020587	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491020588	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
395491020589	substrate binding site [chemical binding]; other site
395491020590	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491020591	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020592	dimer interface [polypeptide binding]; other site
395491020593	conserved gate region; other site
395491020594	putative PBP binding loops; other site
395491020595	ABC-ATPase subunit interface; other site
395491020596	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491020597	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020598	dimer interface [polypeptide binding]; other site
395491020599	conserved gate region; other site
395491020600	putative PBP binding loops; other site
395491020601	ABC-ATPase subunit interface; other site
395491020602	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491020603	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491020604	Walker A/P-loop; other site
395491020605	ATP binding site [chemical binding]; other site
395491020606	Q-loop/lid; other site
395491020607	ABC transporter signature motif; other site
395491020608	Walker B; other site
395491020609	D-loop; other site
395491020610	H-loop/switch region; other site
395491020611	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491020612	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491020613	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491020614	Walker A/P-loop; other site
395491020615	ATP binding site [chemical binding]; other site
395491020616	Q-loop/lid; other site
395491020617	ABC transporter signature motif; other site
395491020618	Walker B; other site
395491020619	D-loop; other site
395491020620	H-loop/switch region; other site
395491020621	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
395491020622	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395491020623	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
395491020624	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
395491020625	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491020626	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491020627	dimerization interface [polypeptide binding]; other site
395491020628	Sulfatase; Region: Sulfatase; cl17466
395491020629	choline-sulfatase; Region: chol_sulfatase; TIGR03417
395491020630	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
395491020631	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
395491020632	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
395491020633	hypothetical protein; Provisional; Region: PRK06102
395491020634	Amidase; Region: Amidase; cl11426
395491020635	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
395491020636	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491020637	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491020638	short chain dehydrogenase; Provisional; Region: PRK06701
395491020639	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491020640	NAD(P) binding site [chemical binding]; other site
395491020641	active site
395491020642	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
395491020643	Transcriptional regulator [Transcription]; Region: IclR; COG1414
395491020644	Bacterial transcriptional regulator; Region: IclR; pfam01614
395491020645	Predicted amidohydrolase [General function prediction only]; Region: COG3964
395491020646	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395491020647	active site
395491020648	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
395491020649	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491020650	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
395491020651	DNA binding residues [nucleotide binding]
395491020652	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395491020653	Uncharacterized conserved protein [Function unknown]; Region: COG2128
395491020654	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952
395491020655	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
395491020656	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
395491020657	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632
395491020658	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
395491020659	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
395491020660	putative NAD(P) binding site [chemical binding]; other site
395491020661	active site
395491020662	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
395491020663	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
395491020664	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
395491020665	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
395491020666	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
395491020667	ligand binding site [chemical binding]; other site
395491020668	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395491020669	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395491020670	Walker A/P-loop; other site
395491020671	ATP binding site [chemical binding]; other site
395491020672	Q-loop/lid; other site
395491020673	ABC transporter signature motif; other site
395491020674	Walker B; other site
395491020675	D-loop; other site
395491020676	H-loop/switch region; other site
395491020677	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395491020678	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491020679	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491020680	TM-ABC transporter signature motif; other site
395491020681	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395491020682	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491020683	TM-ABC transporter signature motif; other site
395491020684	Domain of unknown function (DUF718); Region: DUF718; pfam05336
395491020685	Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772
395491020686	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
395491020687	N- and C-terminal domain interface [polypeptide binding]; other site
395491020688	putative active site [active]
395491020689	putative MgATP binding site [chemical binding]; other site
395491020690	putative catalytic site [active]
395491020691	metal binding site [ion binding]; metal-binding site
395491020692	putative carbohydrate binding site [chemical binding]; other site
395491020693	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
395491020694	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491020695	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491020696	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491020697	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
395491020698	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395491020699	N-terminal plug; other site
395491020700	ligand-binding site [chemical binding]; other site
395491020701	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
395491020702	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
395491020703	Walker A/P-loop; other site
395491020704	ATP binding site [chemical binding]; other site
395491020705	Q-loop/lid; other site
395491020706	ABC transporter signature motif; other site
395491020707	Walker B; other site
395491020708	D-loop; other site
395491020709	H-loop/switch region; other site
395491020710	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
395491020711	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
395491020712	intersubunit interface [polypeptide binding]; other site
395491020713	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
395491020714	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491020715	ABC-ATPase subunit  interface; other site
395491020716	dimer interface [polypeptide binding]; other site
395491020717	putative PBP binding regions; other site
395491020718	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395491020719	ABC-ATPase subunit  interface; other site
395491020720	dimer interface [polypeptide binding]; other site
395491020721	putative PBP binding regions; other site
395491020722	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
395491020723	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
395491020724	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
395491020725	FAD binding pocket [chemical binding]; other site
395491020726	FAD binding motif [chemical binding]; other site
395491020727	phosphate binding motif [ion binding]; other site
395491020728	NAD binding pocket [chemical binding]; other site
395491020729	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395491020730	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
395491020731	choline dehydrogenase; Validated; Region: PRK02106
395491020732	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395491020733	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395491020734	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395491020735	TM-ABC transporter signature motif; other site
395491020736	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395491020737	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395491020738	TM-ABC transporter signature motif; other site
395491020739	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
395491020740	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395491020741	Walker A/P-loop; other site
395491020742	ATP binding site [chemical binding]; other site
395491020743	Q-loop/lid; other site
395491020744	ABC transporter signature motif; other site
395491020745	Walker B; other site
395491020746	D-loop; other site
395491020747	H-loop/switch region; other site
395491020748	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395491020749	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395491020750	Walker A/P-loop; other site
395491020751	ATP binding site [chemical binding]; other site
395491020752	Q-loop/lid; other site
395491020753	ABC transporter signature motif; other site
395491020754	Walker B; other site
395491020755	D-loop; other site
395491020756	H-loop/switch region; other site
395491020757	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395491020758	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
395491020759	putative ligand binding site [chemical binding]; other site
395491020760	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
395491020761	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
395491020762	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
395491020763	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395491020764	active site
395491020765	Protein of unknown function (DUF1616); Region: DUF1616; pfam07760
395491020766	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491020767	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395491020768	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
395491020769	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
395491020770	Ligand binding site; other site
395491020771	Putative Catalytic site; other site
395491020772	DXD motif; other site
395491020773	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
395491020774	SLBB domain; Region: SLBB; pfam10531
395491020775	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491020776	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491020777	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491020778	dimerization interface [polypeptide binding]; other site
395491020779	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
395491020780	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
395491020781	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395491020782	FAD binding site [chemical binding]; other site
395491020783	substrate binding pocket [chemical binding]; other site
395491020784	catalytic base [active]
395491020785	Predicted membrane protein [Function unknown]; Region: COG3918
395491020786	mercuric reductase; Validated; Region: PRK06370
395491020787	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395491020788	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395491020789	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
395491020790	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
395491020791	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395491020792	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
395491020793	inhibitor binding site; inhibition site
395491020794	catalytic Zn binding site [ion binding]; other site
395491020795	structural Zn binding site [ion binding]; other site
395491020796	NADP binding site [chemical binding]; other site
395491020797	tetramer interface [polypeptide binding]; other site
395491020798	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
395491020799	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
395491020800	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395491020801	Soluble P-type ATPase [General function prediction only]; Region: COG4087
395491020802	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
395491020803	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
395491020804	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
395491020805	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
395491020806	Ligand Binding Site [chemical binding]; other site
395491020807	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
395491020808	GAF domain; Region: GAF_3; pfam13492
395491020809	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491020810	dimer interface [polypeptide binding]; other site
395491020811	phosphorylation site [posttranslational modification]
395491020812	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491020813	ATP binding site [chemical binding]; other site
395491020814	Mg2+ binding site [ion binding]; other site
395491020815	G-X-G motif; other site
395491020816	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491020817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491020818	active site
395491020819	phosphorylation site [posttranslational modification]
395491020820	intermolecular recognition site; other site
395491020821	dimerization interface [polypeptide binding]; other site
395491020822	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491020823	DNA binding site [nucleotide binding]
395491020824	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
395491020825	active site
395491020826	phosphorylation site [posttranslational modification]
395491020827	Porin subfamily; Region: Porin_2; pfam02530
395491020828	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
395491020829	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395491020830	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
395491020831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020832	dimer interface [polypeptide binding]; other site
395491020833	conserved gate region; other site
395491020834	putative PBP binding loops; other site
395491020835	ABC-ATPase subunit interface; other site
395491020836	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
395491020837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020838	dimer interface [polypeptide binding]; other site
395491020839	conserved gate region; other site
395491020840	putative PBP binding loops; other site
395491020841	ABC-ATPase subunit interface; other site
395491020842	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
395491020843	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
395491020844	Walker A/P-loop; other site
395491020845	ATP binding site [chemical binding]; other site
395491020846	Q-loop/lid; other site
395491020847	ABC transporter signature motif; other site
395491020848	Walker B; other site
395491020849	D-loop; other site
395491020850	H-loop/switch region; other site
395491020851	TOBE-like domain; Region: TOBE_3; pfam12857
395491020852	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
395491020853	peptidase T; Region: peptidase-T; TIGR01882
395491020854	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
395491020855	metal binding site [ion binding]; metal-binding site
395491020856	dimer interface [polypeptide binding]; other site
395491020857	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
395491020858	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395491020859	active site
395491020860	metal binding site [ion binding]; metal-binding site
395491020861	hexamer interface [polypeptide binding]; other site
395491020862	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395491020863	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395491020864	Walker A/P-loop; other site
395491020865	ATP binding site [chemical binding]; other site
395491020866	Q-loop/lid; other site
395491020867	ABC transporter signature motif; other site
395491020868	Walker B; other site
395491020869	D-loop; other site
395491020870	H-loop/switch region; other site
395491020871	TOBE domain; Region: TOBE_2; pfam08402
395491020872	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491020873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020874	dimer interface [polypeptide binding]; other site
395491020875	conserved gate region; other site
395491020876	putative PBP binding loops; other site
395491020877	ABC-ATPase subunit interface; other site
395491020878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020879	dimer interface [polypeptide binding]; other site
395491020880	conserved gate region; other site
395491020881	putative PBP binding loops; other site
395491020882	ABC-ATPase subunit interface; other site
395491020883	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491020884	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491020885	hypothetical protein; Provisional; Region: PRK05968
395491020886	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
395491020887	homodimer interface [polypeptide binding]; other site
395491020888	substrate-cofactor binding pocket; other site
395491020889	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395491020890	catalytic residue [active]
395491020891	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395491020892	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491020893	DNA-binding site [nucleotide binding]; DNA binding site
395491020894	FCD domain; Region: FCD; pfam07729
395491020895	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
395491020896	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395491020897	substrate binding pocket [chemical binding]; other site
395491020898	catalytic triad [active]
395491020899	short chain dehydrogenase; Provisional; Region: PRK06482
395491020900	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395491020901	NADP binding site [chemical binding]; other site
395491020902	active site
395491020903	steroid binding site; other site
395491020904	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491020905	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491020906	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395491020907	putative effector binding pocket; other site
395491020908	putative dimerization interface [polypeptide binding]; other site
395491020909	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395491020910	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491020911	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
395491020912	dimerization interface [polypeptide binding]; other site
395491020913	substrate binding pocket [chemical binding]; other site
395491020914	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
395491020915	putative catalytic site [active]
395491020916	putative metal binding site [ion binding]; other site
395491020917	putative phosphate binding site [ion binding]; other site
395491020918	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
395491020919	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
395491020920	putative active site [active]
395491020921	catalytic site [active]
395491020922	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
395491020923	putative active site [active]
395491020924	catalytic site [active]
395491020925	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
395491020926	Fe-S cluster binding site [ion binding]; other site
395491020927	active site
395491020928	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
395491020929	PAS fold; Region: PAS_4; pfam08448
395491020930	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
395491020931	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395491020932	GAF domain; Region: GAF; pfam01590
395491020933	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491020934	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491020935	dimer interface [polypeptide binding]; other site
395491020936	phosphorylation site [posttranslational modification]
395491020937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491020938	ATP binding site [chemical binding]; other site
395491020939	Mg2+ binding site [ion binding]; other site
395491020940	G-X-G motif; other site
395491020941	Response regulator receiver domain; Region: Response_reg; pfam00072
395491020942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491020943	active site
395491020944	phosphorylation site [posttranslational modification]
395491020945	intermolecular recognition site; other site
395491020946	dimerization interface [polypeptide binding]; other site
395491020947	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395491020948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491020949	active site
395491020950	phosphorylation site [posttranslational modification]
395491020951	intermolecular recognition site; other site
395491020952	dimerization interface [polypeptide binding]; other site
395491020953	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
395491020954	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
395491020955	glutathione s-transferase; Provisional; Region: PTZ00057
395491020956	GSH binding site (G-site) [chemical binding]; other site
395491020957	C-terminal domain interface [polypeptide binding]; other site
395491020958	dimer interface [polypeptide binding]; other site
395491020959	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
395491020960	dimer interface [polypeptide binding]; other site
395491020961	N-terminal domain interface [polypeptide binding]; other site
395491020962	substrate binding pocket (H-site) [chemical binding]; other site
395491020963	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
395491020964	nucleotide binding site [chemical binding]; other site
395491020965	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
395491020966	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
395491020967	active site
395491020968	DNA binding site [nucleotide binding]
395491020969	Int/Topo IB signature motif; other site
395491020970	catalytic residues [active]
395491020971	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
395491020972	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
395491020973	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
395491020974	active site
395491020975	catalytic site [active]
395491020976	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491020977	classical (c) SDRs; Region: SDR_c; cd05233
395491020978	NAD(P) binding site [chemical binding]; other site
395491020979	active site
395491020980	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395491020981	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
395491020982	putative binding site; other site
395491020983	Caspase domain; Region: Peptidase_C14; pfam00656
395491020984	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
395491020985	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491020986	putative substrate translocation pore; other site
395491020987	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395491020988	Sulfatase; Region: Sulfatase; pfam00884
395491020989	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395491020990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020991	dimer interface [polypeptide binding]; other site
395491020992	conserved gate region; other site
395491020993	putative PBP binding loops; other site
395491020994	ABC-ATPase subunit interface; other site
395491020995	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491020996	dimer interface [polypeptide binding]; other site
395491020997	putative PBP binding loops; other site
395491020998	ABC-ATPase subunit interface; other site
395491020999	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395491021000	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395491021001	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491021002	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491021003	LysR substrate binding domain; Region: LysR_substrate; pfam03466
395491021004	dimerization interface [polypeptide binding]; other site
395491021005	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395491021006	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395491021007	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
395491021008	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
395491021009	dimer interface [polypeptide binding]; other site
395491021010	active site
395491021011	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
395491021012	Coenzyme A transferase; Region: CoA_trans; cl17247
395491021013	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
395491021014	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
395491021015	Bacterial transcriptional regulator; Region: IclR; pfam01614
395491021016	Predicted transcriptional regulator [Transcription]; Region: COG4189
395491021017	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395491021018	dimerization interface [polypeptide binding]; other site
395491021019	putative DNA binding site [nucleotide binding]; other site
395491021020	putative Zn2+ binding site [ion binding]; other site
395491021021	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
395491021022	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
395491021023	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
395491021024	substrate binding site [chemical binding]; other site
395491021025	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491021026	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491021027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491021028	dimer interface [polypeptide binding]; other site
395491021029	conserved gate region; other site
395491021030	putative PBP binding loops; other site
395491021031	ABC-ATPase subunit interface; other site
395491021032	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491021033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491021034	dimer interface [polypeptide binding]; other site
395491021035	conserved gate region; other site
395491021036	putative PBP binding loops; other site
395491021037	ABC-ATPase subunit interface; other site
395491021038	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
395491021039	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491021040	Walker A/P-loop; other site
395491021041	ATP binding site [chemical binding]; other site
395491021042	Q-loop/lid; other site
395491021043	ABC transporter signature motif; other site
395491021044	Walker B; other site
395491021045	D-loop; other site
395491021046	H-loop/switch region; other site
395491021047	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395491021048	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
395491021049	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491021050	Walker A/P-loop; other site
395491021051	ATP binding site [chemical binding]; other site
395491021052	Q-loop/lid; other site
395491021053	ABC transporter signature motif; other site
395491021054	Walker B; other site
395491021055	D-loop; other site
395491021056	H-loop/switch region; other site
395491021057	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491021058	CHASE domain; Region: CHASE; cl01369
395491021059	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491021060	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491021061	metal binding site [ion binding]; metal-binding site
395491021062	active site
395491021063	I-site; other site
395491021064	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395491021065	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
395491021066	MobA/MobL family; Region: MobA_MobL; pfam03389
395491021067	AAA domain; Region: AAA_30; pfam13604
395491021068	Family description; Region: UvrD_C_2; pfam13538
395491021069	HipA N-terminal domain; Region: Couple_hipA; pfam13657
395491021070	HipA-like N-terminal domain; Region: HipA_N; pfam07805
395491021071	HipA-like C-terminal domain; Region: HipA_C; pfam07804
395491021072	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491021073	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491021074	non-specific DNA binding site [nucleotide binding]; other site
395491021075	salt bridge; other site
395491021076	sequence-specific DNA binding site [nucleotide binding]; other site
395491021077	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
395491021078	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
395491021079	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
395491021080	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395491021081	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395491021082	metal binding site [ion binding]; metal-binding site
395491021083	active site
395491021084	I-site; other site
395491021085	Staphylococcal nuclease homologues; Region: SNc; smart00318
395491021086	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
395491021087	Catalytic site; other site
395491021088	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
395491021089	ligand binding site [chemical binding]; other site
395491021090	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
395491021091	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
395491021092	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
395491021093	potential catalytic triad [active]
395491021094	conserved cys residue [active]
395491021095	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395491021096	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
395491021097	active site 1 [active]
395491021098	dimer interface [polypeptide binding]; other site
395491021099	hexamer interface [polypeptide binding]; other site
395491021100	active site 2 [active]
395491021101	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
395491021102	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
395491021103	catalytic residues [active]
395491021104	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395491021105	classical (c) SDRs; Region: SDR_c; cd05233
395491021106	NAD(P) binding site [chemical binding]; other site
395491021107	active site
395491021108	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395491021109	active site
395491021110	metal binding site [ion binding]; metal-binding site
395491021111	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491021112	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
395491021113	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
395491021114	putative molybdopterin cofactor binding site [chemical binding]; other site
395491021115	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
395491021116	putative molybdopterin cofactor binding site; other site
395491021117	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395491021118	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395491021119	DNA binding site [nucleotide binding]
395491021120	Predicted ATPase [General function prediction only]; Region: COG3903
395491021121	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
395491021122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395491021123	active site
395491021124	phosphorylation site [posttranslational modification]
395491021125	intermolecular recognition site; other site
395491021126	dimerization interface [polypeptide binding]; other site
395491021127	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491021128	DNA binding residues [nucleotide binding]
395491021129	dimerization interface [polypeptide binding]; other site
395491021130	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491021131	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
395491021132	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
395491021133	SnoaL-like domain; Region: SnoaL_3; pfam13474
395491021134	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
395491021135	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
395491021136	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
395491021137	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
395491021138	FMN binding site [chemical binding]; other site
395491021139	substrate binding site [chemical binding]; other site
395491021140	putative catalytic residue [active]
395491021141	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395491021142	classical (c) SDRs; Region: SDR_c; cd05233
395491021143	NAD(P) binding site [chemical binding]; other site
395491021144	active site
395491021145	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
395491021146	homotrimer interaction site [polypeptide binding]; other site
395491021147	putative active site [active]
395491021148	enoyl-CoA hydratase; Provisional; Region: PRK07468
395491021149	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395491021150	substrate binding site [chemical binding]; other site
395491021151	oxyanion hole (OAH) forming residues; other site
395491021152	trimer interface [polypeptide binding]; other site
395491021153	Isochorismatase family; Region: Isochorismatase; pfam00857
395491021154	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
395491021155	catalytic triad [active]
395491021156	conserved cis-peptide bond; other site
395491021157	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
395491021158	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
395491021159	dimer interface [polypeptide binding]; other site
395491021160	NADP binding site [chemical binding]; other site
395491021161	catalytic residues [active]
395491021162	Predicted flavoprotein [General function prediction only]; Region: COG0431
395491021163	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491021164	D-cysteine desulfhydrase; Validated; Region: PRK03910
395491021165	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
395491021166	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395491021167	catalytic residue [active]
395491021168	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395491021169	classical (c) SDRs; Region: SDR_c; cd05233
395491021170	NAD(P) binding site [chemical binding]; other site
395491021171	active site
395491021172	Epoxide hydrolase N terminus; Region: EHN; pfam06441
395491021173	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491021174	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
395491021175	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395491021176	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491021177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491021178	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
395491021179	putative effector binding pocket; other site
395491021180	putative dimerization interface [polypeptide binding]; other site
395491021181	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
395491021182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491021183	active site
395491021184	phosphorylation site [posttranslational modification]
395491021185	intermolecular recognition site; other site
395491021186	dimerization interface [polypeptide binding]; other site
395491021187	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491021188	DNA binding residues [nucleotide binding]
395491021189	dimerization interface [polypeptide binding]; other site
395491021190	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491021191	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021192	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491021193	putative active site [active]
395491021194	heme pocket [chemical binding]; other site
395491021195	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021196	putative active site [active]
395491021197	heme pocket [chemical binding]; other site
395491021198	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021199	PAS domain; Region: PAS_9; pfam13426
395491021200	putative active site [active]
395491021201	heme pocket [chemical binding]; other site
395491021202	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395491021203	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491021204	dimer interface [polypeptide binding]; other site
395491021205	phosphorylation site [posttranslational modification]
395491021206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491021207	ATP binding site [chemical binding]; other site
395491021208	Mg2+ binding site [ion binding]; other site
395491021209	G-X-G motif; other site
395491021210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491021211	Response regulator receiver domain; Region: Response_reg; pfam00072
395491021212	active site
395491021213	phosphorylation site [posttranslational modification]
395491021214	intermolecular recognition site; other site
395491021215	dimerization interface [polypeptide binding]; other site
395491021216	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491021217	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021218	putative active site [active]
395491021219	heme pocket [chemical binding]; other site
395491021220	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021221	putative active site [active]
395491021222	heme pocket [chemical binding]; other site
395491021223	hypothetical protein; Provisional; Region: PRK13560
395491021224	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021225	putative active site [active]
395491021226	heme pocket [chemical binding]; other site
395491021227	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021228	putative active site [active]
395491021229	heme pocket [chemical binding]; other site
395491021230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021231	putative active site [active]
395491021232	heme pocket [chemical binding]; other site
395491021233	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021234	putative active site [active]
395491021235	heme pocket [chemical binding]; other site
395491021236	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491021237	dimer interface [polypeptide binding]; other site
395491021238	phosphorylation site [posttranslational modification]
395491021239	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491021240	ATP binding site [chemical binding]; other site
395491021241	Mg2+ binding site [ion binding]; other site
395491021242	G-X-G motif; other site
395491021243	Epoxide hydrolase N terminus; Region: EHN; pfam06441
395491021244	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395491021245	Transglycosylase; Region: Transgly; pfam00912
395491021246	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
395491021247	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
395491021248	BA14K-like protein; Region: BA14K; pfam07886
395491021249	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395491021250	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395491021251	Predicted membrane protein [Function unknown]; Region: COG2323
395491021252	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
395491021253	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
395491021254	dinuclear metal binding motif [ion binding]; other site
395491021255	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
395491021256	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491021257	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
395491021258	DNA binding residues [nucleotide binding]
395491021259	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395491021260	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
395491021261	putative NAD(P) binding site [chemical binding]; other site
395491021262	active site
395491021263	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
395491021264	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
395491021265	alpha-galactosidase; Provisional; Region: PRK15076
395491021266	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
395491021267	NAD binding site [chemical binding]; other site
395491021268	sugar binding site [chemical binding]; other site
395491021269	divalent metal binding site [ion binding]; other site
395491021270	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
395491021271	dimer interface [polypeptide binding]; other site
395491021272	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
395491021273	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491021274	Walker A/P-loop; other site
395491021275	ATP binding site [chemical binding]; other site
395491021276	Q-loop/lid; other site
395491021277	ABC transporter signature motif; other site
395491021278	Walker B; other site
395491021279	D-loop; other site
395491021280	H-loop/switch region; other site
395491021281	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491021282	Walker A/P-loop; other site
395491021283	ATP binding site [chemical binding]; other site
395491021284	Q-loop/lid; other site
395491021285	ABC transporter signature motif; other site
395491021286	Walker B; other site
395491021287	D-loop; other site
395491021288	H-loop/switch region; other site
395491021289	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491021290	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491021291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491021292	dimer interface [polypeptide binding]; other site
395491021293	conserved gate region; other site
395491021294	putative PBP binding loops; other site
395491021295	ABC-ATPase subunit interface; other site
395491021296	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491021297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491021298	dimer interface [polypeptide binding]; other site
395491021299	conserved gate region; other site
395491021300	putative PBP binding loops; other site
395491021301	ABC-ATPase subunit interface; other site
395491021302	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
395491021303	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
395491021304	alpha-galactosidase; Provisional; Region: PRK15076
395491021305	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
395491021306	NAD binding site [chemical binding]; other site
395491021307	sugar binding site [chemical binding]; other site
395491021308	divalent metal binding site [ion binding]; other site
395491021309	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
395491021310	dimer interface [polypeptide binding]; other site
395491021311	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
395491021312	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395491021313	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491021314	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395491021315	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491021316	S-adenosylmethionine binding site [chemical binding]; other site
395491021317	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491021318	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491021319	non-specific DNA binding site [nucleotide binding]; other site
395491021320	salt bridge; other site
395491021321	sequence-specific DNA binding site [nucleotide binding]; other site
395491021322	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395491021323	hydroxyglutarate oxidase; Provisional; Region: PRK11728
395491021324	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
395491021325	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395491021326	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
395491021327	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395491021328	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395491021329	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491021330	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491021331	ligand binding site [chemical binding]; other site
395491021332	flexible hinge region; other site
395491021333	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
395491021334	non-specific DNA binding site [nucleotide binding]; other site
395491021335	salt bridge; other site
395491021336	sequence-specific DNA binding site [nucleotide binding]; other site
395491021337	Predicted membrane protein [Function unknown]; Region: COG4280
395491021338	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
395491021339	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
395491021340	active site
395491021341	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491021342	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491021343	Uncharacterized conserved protein [Function unknown]; Region: COG1262
395491021344	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395491021345	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395491021346	Sulfatase; Region: Sulfatase; pfam00884
395491021347	Sulfatase; Region: Sulfatase; cl17466
395491021348	Response regulator receiver domain; Region: Response_reg; pfam00072
395491021349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491021350	active site
395491021351	phosphorylation site [posttranslational modification]
395491021352	intermolecular recognition site; other site
395491021353	dimerization interface [polypeptide binding]; other site
395491021354	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
395491021355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491021356	active site
395491021357	phosphorylation site [posttranslational modification]
395491021358	intermolecular recognition site; other site
395491021359	dimerization interface [polypeptide binding]; other site
395491021360	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395491021361	DNA binding residues [nucleotide binding]
395491021362	dimerization interface [polypeptide binding]; other site
395491021363	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395491021364	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
395491021365	dimer interface [polypeptide binding]; other site
395491021366	phosphorylation site [posttranslational modification]
395491021367	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491021368	ATP binding site [chemical binding]; other site
395491021369	Mg2+ binding site [ion binding]; other site
395491021370	G-X-G motif; other site
395491021371	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395491021372	Sulfatase; Region: Sulfatase; pfam00884
395491021373	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
395491021374	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491021375	motif II; other site
395491021376	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
395491021377	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
395491021378	heme-binding residues [chemical binding]; other site
395491021379	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491021380	binding surface
395491021381	TPR motif; other site
395491021382	Uncharacterized conserved protein [Function unknown]; Region: COG5361
395491021383	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
395491021384	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
395491021385	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
395491021386	active sites [active]
395491021387	tetramer interface [polypeptide binding]; other site
395491021388	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
395491021389	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491021390	Walker A/P-loop; other site
395491021391	ATP binding site [chemical binding]; other site
395491021392	Q-loop/lid; other site
395491021393	ABC transporter signature motif; other site
395491021394	Walker B; other site
395491021395	D-loop; other site
395491021396	H-loop/switch region; other site
395491021397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491021398	dimer interface [polypeptide binding]; other site
395491021399	conserved gate region; other site
395491021400	putative PBP binding loops; other site
395491021401	ABC-ATPase subunit interface; other site
395491021402	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491021403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491021404	dimer interface [polypeptide binding]; other site
395491021405	conserved gate region; other site
395491021406	putative PBP binding loops; other site
395491021407	ABC-ATPase subunit interface; other site
395491021408	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491021409	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491021410	substrate binding pocket [chemical binding]; other site
395491021411	membrane-bound complex binding site; other site
395491021412	hinge residues; other site
395491021413	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
395491021414	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491021415	DNA-binding site [nucleotide binding]; DNA binding site
395491021416	UTRA domain; Region: UTRA; pfam07702
395491021417	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491021418	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
395491021419	ligand binding site [chemical binding]; other site
395491021420	flexible hinge region; other site
395491021421	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491021422	Src homology 2 (SH2) domain; Region: SH2; cl15255
395491021423	phosphotyrosine binding pocket [polypeptide binding]; other site
395491021424	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491021425	DNA-binding site [nucleotide binding]; DNA binding site
395491021426	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
395491021427	UTRA domain; Region: UTRA; pfam07702
395491021428	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
395491021429	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
395491021430	active site
395491021431	imidazolonepropionase; Validated; Region: PRK09356
395491021432	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
395491021433	active site
395491021434	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
395491021435	active sites [active]
395491021436	tetramer interface [polypeptide binding]; other site
395491021437	N-formylglutamate amidohydrolase; Region: FGase; cl01522
395491021438	urocanate hydratase; Provisional; Region: PRK05414
395491021439	HutD; Region: HutD; pfam05962
395491021440	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395491021441	HSP70 interaction site [polypeptide binding]; other site
395491021442	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
395491021443	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
395491021444	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
395491021445	PAS fold; Region: PAS_4; pfam08448
395491021446	PAS domain S-box; Region: sensory_box; TIGR00229
395491021447	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021448	putative active site [active]
395491021449	heme pocket [chemical binding]; other site
395491021450	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395491021451	HWE histidine kinase; Region: HWE_HK; pfam07536
395491021452	hypothetical protein; Provisional; Region: PRK13559
395491021453	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021454	putative active site [active]
395491021455	heme pocket [chemical binding]; other site
395491021456	Histidine kinase; Region: HisKA_2; pfam07568
395491021457	response regulator; Provisional; Region: PRK13435
395491021458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491021459	active site
395491021460	phosphorylation site [posttranslational modification]
395491021461	intermolecular recognition site; other site
395491021462	dimerization interface [polypeptide binding]; other site
395491021463	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395491021464	Walker A motif; other site
395491021465	ATP binding site [chemical binding]; other site
395491021466	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491021467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491021468	active site
395491021469	phosphorylation site [posttranslational modification]
395491021470	intermolecular recognition site; other site
395491021471	dimerization interface [polypeptide binding]; other site
395491021472	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491021473	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
395491021474	LssY C-terminus; Region: LssY_C; pfam14067
395491021475	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
395491021476	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395491021477	ligand binding site [chemical binding]; other site
395491021478	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
395491021479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
395491021480	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
395491021481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
395491021482	Predicted integral membrane protein [Function unknown]; Region: COG5616
395491021483	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491021484	TPR motif; other site
395491021485	binding surface
395491021486	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491021487	binding surface
395491021488	TPR motif; other site
395491021489	Uncharacterized conserved protein [Function unknown]; Region: COG5361
395491021490	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
395491021491	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
395491021492	hypothetical protein; Provisional; Region: PRK10621
395491021493	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395491021494	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
395491021495	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
395491021496	putative DNA binding site [nucleotide binding]; other site
395491021497	putative homodimer interface [polypeptide binding]; other site
395491021498	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
395491021499	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
395491021500	DNA binding site [nucleotide binding]
395491021501	heterodimer interface [polypeptide binding]; other site
395491021502	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
395491021503	Protein of unknown function (DUF497); Region: DUF497; cl01108
395491021504	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
395491021505	Protein of unknown function (DUF983); Region: DUF983; cl02211
395491021506	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395491021507	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395491021508	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395491021509	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
395491021510	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
395491021511	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
395491021512	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
395491021513	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
395491021514	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
395491021515	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
395491021516	Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489
395491021517	Predicted integral membrane protein [Function unknown]; Region: COG5446
395491021518	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395491021519	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
395491021520	conserved cys residue [active]
395491021521	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491021522	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395491021523	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
395491021524	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
395491021525	active site
395491021526	DNA binding site [nucleotide binding]
395491021527	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
395491021528	DNA binding site [nucleotide binding]
395491021529	PAS fold; Region: PAS; pfam00989
395491021530	PAS domain; Region: PAS; smart00091
395491021531	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
395491021532	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395491021533	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395491021534	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395491021535	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395491021536	active site
395491021537	response regulator; Provisional; Region: PRK13435
395491021538	cheY-homologous receiver domain; Region: REC; smart00448
395491021539	active site
395491021540	phosphorylation site [posttranslational modification]
395491021541	intermolecular recognition site; other site
395491021542	HipA N-terminal domain; Region: Couple_hipA; cl11853
395491021543	HipA-like N-terminal domain; Region: HipA_N; pfam07805
395491021544	HipA-like C-terminal domain; Region: HipA_C; pfam07804
395491021545	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491021546	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491021547	non-specific DNA binding site [nucleotide binding]; other site
395491021548	salt bridge; other site
395491021549	sequence-specific DNA binding site [nucleotide binding]; other site
395491021550	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
395491021551	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
395491021552	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
395491021553	active site
395491021554	DNA binding site [nucleotide binding]
395491021555	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
395491021556	DNA binding site [nucleotide binding]
395491021557	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
395491021558	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
395491021559	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491021560	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491021561	ligand binding site [chemical binding]; other site
395491021562	flexible hinge region; other site
395491021563	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395491021564	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
395491021565	putative hydrolase; Provisional; Region: PRK11460
395491021566	Low affinity iron permease; Region: Iron_permease; pfam04120
395491021567	Transposase; Region: HTH_Tnp_1; pfam01527
395491021568	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395491021569	Ligand Binding Site [chemical binding]; other site
395491021570	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395491021571	Ligand Binding Site [chemical binding]; other site
395491021572	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395491021573	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395491021574	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
395491021575	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
395491021576	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
395491021577	putative DNA binding site [nucleotide binding]; other site
395491021578	putative homodimer interface [polypeptide binding]; other site
395491021579	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
395491021580	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
395491021581	putative homodimer interface [polypeptide binding]; other site
395491021582	putative DNA binding site [nucleotide binding]; other site
395491021583	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491021584	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491021585	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
395491021586	dimerization interface [polypeptide binding]; other site
395491021587	substrate binding pocket [chemical binding]; other site
395491021588	Transposase; Region: HTH_Tnp_1; pfam01527
395491021589	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
395491021590	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
395491021591	Cell division protein 48 (CDC48), domain 2; Region: CDC48_2; pfam02933
395491021592	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491021593	Walker A motif; other site
395491021594	ATP binding site [chemical binding]; other site
395491021595	Walker B motif; other site
395491021596	arginine finger; other site
395491021597	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395491021598	Walker A motif; other site
395491021599	ATP binding site [chemical binding]; other site
395491021600	Walker B motif; other site
395491021601	arginine finger; other site
395491021602	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
395491021603	Sterile alpha motif; Region: SAM; smart00454
395491021604	SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487
395491021605	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
395491021606	cyclase homology domain; Region: CHD; cd07302
395491021607	nucleotidyl binding site; other site
395491021608	metal binding site [ion binding]; metal-binding site
395491021609	dimer interface [polypeptide binding]; other site
395491021610	AAA ATPase domain; Region: AAA_16; pfam13191
395491021611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395491021612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491021613	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
395491021614	dimerization interface [polypeptide binding]; other site
395491021615	substrate binding pocket [chemical binding]; other site
395491021616	Arc-like DNA binding domain; Region: Arc; pfam03869
395491021617	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
395491021618	additional DNA contacts [nucleotide binding]; other site
395491021619	mismatch recognition site; other site
395491021620	active site
395491021621	zinc binding site [ion binding]; other site
395491021622	DNA intercalation site [nucleotide binding]; other site
395491021623	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
395491021624	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
395491021625	cofactor binding site; other site
395491021626	DNA binding site [nucleotide binding]
395491021627	substrate interaction site [chemical binding]; other site
395491021628	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
395491021629	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
395491021630	GIY-YIG motif/motif A; other site
395491021631	active site
395491021632	catalytic site [active]
395491021633	metal binding site [ion binding]; metal-binding site
395491021634	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
395491021635	RES domain; Region: RES; smart00953
395491021636	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
395491021637	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
395491021638	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
395491021639	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395491021640	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395491021641	dimerization interface [polypeptide binding]; other site
395491021642	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395491021643	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
395491021644	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
395491021645	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
395491021646	heterodimer interface [polypeptide binding]; other site
395491021647	multimer interface [polypeptide binding]; other site
395491021648	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
395491021649	active site
395491021650	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
395491021651	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
395491021652	heterodimer interface [polypeptide binding]; other site
395491021653	active site
395491021654	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975
395491021655	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
395491021656	tetramer interface [polypeptide binding]; other site
395491021657	Predicted transcriptional regulator [Transcription]; Region: COG2944
395491021658	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491021659	non-specific DNA binding site [nucleotide binding]; other site
395491021660	salt bridge; other site
395491021661	sequence-specific DNA binding site [nucleotide binding]; other site
395491021662	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
395491021663	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
395491021664	NADP binding site [chemical binding]; other site
395491021665	homodimer interface [polypeptide binding]; other site
395491021666	active site
395491021667	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
395491021668	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
395491021669	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
395491021670	shikimate binding site; other site
395491021671	NAD(P) binding site [chemical binding]; other site
395491021672	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395491021673	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395491021674	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395491021675	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395491021676	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395491021677	Walker A/P-loop; other site
395491021678	ATP binding site [chemical binding]; other site
395491021679	Q-loop/lid; other site
395491021680	ABC transporter signature motif; other site
395491021681	Walker B; other site
395491021682	D-loop; other site
395491021683	H-loop/switch region; other site
395491021684	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395491021685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491021686	dimer interface [polypeptide binding]; other site
395491021687	conserved gate region; other site
395491021688	putative PBP binding loops; other site
395491021689	ABC-ATPase subunit interface; other site
395491021690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491021691	dimer interface [polypeptide binding]; other site
395491021692	conserved gate region; other site
395491021693	putative PBP binding loops; other site
395491021694	ABC-ATPase subunit interface; other site
395491021695	Dehydroquinase class II; Region: DHquinase_II; pfam01220
395491021696	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
395491021697	trimer interface [polypeptide binding]; other site
395491021698	active site
395491021699	dimer interface [polypeptide binding]; other site
395491021700	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395491021701	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395491021702	substrate binding pocket [chemical binding]; other site
395491021703	membrane-bound complex binding site; other site
395491021704	hinge residues; other site
395491021705	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395491021706	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
395491021707	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
395491021708	dimer interface [polypeptide binding]; other site
395491021709	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
395491021710	active site
395491021711	Fe binding site [ion binding]; other site
395491021712	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491021713	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491021714	DNA-binding site [nucleotide binding]; DNA binding site
395491021715	FCD domain; Region: FCD; pfam07729
395491021716	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395491021717	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395491021718	DNA-binding site [nucleotide binding]; DNA binding site
395491021719	FCD domain; Region: FCD; pfam07729
395491021720	cyclase homology domain; Region: CHD; cd07302
395491021721	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491021722	TPR repeat; Region: TPR_11; pfam13414
395491021723	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491021724	binding surface
395491021725	TPR motif; other site
395491021726	TPR repeat; Region: TPR_11; pfam13414
395491021727	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491021728	binding surface
395491021729	TPR motif; other site
395491021730	TPR repeat; Region: TPR_11; pfam13414
395491021731	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491021732	binding surface
395491021733	TPR motif; other site
395491021734	TPR repeat; Region: TPR_11; pfam13414
395491021735	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
395491021736	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
395491021737	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491021738	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
395491021739	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928
395491021740	NodB motif; other site
395491021741	putative active site [active]
395491021742	putative catalytic site [active]
395491021743	putative Zn binding site [ion binding]; other site
395491021744	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491021745	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395491021746	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395491021747	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395491021748	catalytic loop [active]
395491021749	iron binding site [ion binding]; other site
395491021750	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491021751	cyclase homology domain; Region: CHD; cd07302
395491021752	nucleotidyl binding site; other site
395491021753	metal binding site [ion binding]; metal-binding site
395491021754	dimer interface [polypeptide binding]; other site
395491021755	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395491021756	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395491021757	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395491021758	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
395491021759	putative ion selectivity filter; other site
395491021760	putative pore gating glutamate residue; other site
395491021761	putative H+/Cl- coupling transport residue; other site
395491021762	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
395491021763	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
395491021764	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395491021765	Predicted transcriptional regulator [Transcription]; Region: COG1959
395491021766	Transcriptional regulator; Region: Rrf2; pfam02082
395491021767	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395491021768	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491021769	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
395491021770	Walker A/P-loop; other site
395491021771	ATP binding site [chemical binding]; other site
395491021772	Q-loop/lid; other site
395491021773	ABC transporter signature motif; other site
395491021774	Walker B; other site
395491021775	D-loop; other site
395491021776	H-loop/switch region; other site
395491021777	S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692
395491021778	Protein of unknown function (DUF3095); Region: DUF3095; pfam11294
395491021779	Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; Region: TUDOR; cd04508
395491021780	dimethylated arginine/lysine binding site [chemical binding]; other site
395491021781	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395491021782	active site
395491021783	Isochorismatase family; Region: Isochorismatase; pfam00857
395491021784	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
395491021785	catalytic triad [active]
395491021786	conserved cis-peptide bond; other site
395491021787	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
395491021788	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
395491021789	homodimer interface [polypeptide binding]; other site
395491021790	NAD binding pocket [chemical binding]; other site
395491021791	ATP binding pocket [chemical binding]; other site
395491021792	Mg binding site [ion binding]; other site
395491021793	active-site loop [active]
395491021794	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
395491021795	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
395491021796	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395491021797	NAD(P) binding site [chemical binding]; other site
395491021798	active site
395491021799	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
395491021800	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
395491021801	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395491021802	cyclase homology domain; Region: CHD; cd07302
395491021803	nucleotidyl binding site; other site
395491021804	metal binding site [ion binding]; metal-binding site
395491021805	dimer interface [polypeptide binding]; other site
395491021806	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395491021807	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491021808	Walker A/P-loop; other site
395491021809	ATP binding site [chemical binding]; other site
395491021810	Q-loop/lid; other site
395491021811	ABC transporter signature motif; other site
395491021812	Walker B; other site
395491021813	D-loop; other site
395491021814	H-loop/switch region; other site
395491021815	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491021816	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395491021817	Walker A/P-loop; other site
395491021818	ATP binding site [chemical binding]; other site
395491021819	Q-loop/lid; other site
395491021820	ABC transporter signature motif; other site
395491021821	Walker B; other site
395491021822	D-loop; other site
395491021823	H-loop/switch region; other site
395491021824	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395491021825	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395491021826	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
395491021827	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395491021828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491021829	dimer interface [polypeptide binding]; other site
395491021830	conserved gate region; other site
395491021831	putative PBP binding loops; other site
395491021832	ABC-ATPase subunit interface; other site
395491021833	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
395491021834	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395491021835	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395491021836	dimer interface [polypeptide binding]; other site
395491021837	conserved gate region; other site
395491021838	putative PBP binding loops; other site
395491021839	ABC-ATPase subunit interface; other site
395491021840	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
395491021841	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
395491021842	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
395491021843	putative ADP-binding pocket [chemical binding]; other site
395491021844	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395491021845	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
395491021846	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395491021847	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395491021848	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491021849	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
395491021850	Walker A/P-loop; other site
395491021851	ATP binding site [chemical binding]; other site
395491021852	Q-loop/lid; other site
395491021853	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395491021854	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491021855	ABC transporter signature motif; other site
395491021856	Walker B; other site
395491021857	D-loop; other site
395491021858	H-loop/switch region; other site
395491021859	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395491021860	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395491021861	ligand binding site [chemical binding]; other site
395491021862	flexible hinge region; other site
395491021863	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
395491021864	metabolite-proton symporter; Region: 2A0106; TIGR00883
395491021865	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491021866	putative substrate translocation pore; other site
395491021867	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
395491021868	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
395491021869	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
395491021870	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
395491021871	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
395491021872	D-pathway; other site
395491021873	Putative ubiquinol binding site [chemical binding]; other site
395491021874	Low-spin heme (heme b) binding site [chemical binding]; other site
395491021875	Putative water exit pathway; other site
395491021876	Binuclear center (heme o3/CuB) [ion binding]; other site
395491021877	K-pathway; other site
395491021878	Putative proton exit pathway; other site
395491021879	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
395491021880	Subunit I/III interface [polypeptide binding]; other site
395491021881	Subunit III/IV interface [polypeptide binding]; other site
395491021882	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
395491021883	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
395491021884	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021885	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395491021886	putative active site [active]
395491021887	heme pocket [chemical binding]; other site
395491021888	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395491021889	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395491021890	putative active site [active]
395491021891	heme pocket [chemical binding]; other site
395491021892	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395491021893	dimer interface [polypeptide binding]; other site
395491021894	phosphorylation site [posttranslational modification]
395491021895	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395491021896	ATP binding site [chemical binding]; other site
395491021897	Mg2+ binding site [ion binding]; other site
395491021898	G-X-G motif; other site
395491021899	Response regulator receiver domain; Region: Response_reg; pfam00072
395491021900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395491021901	active site
395491021902	phosphorylation site [posttranslational modification]
395491021903	intermolecular recognition site; other site
395491021904	dimerization interface [polypeptide binding]; other site
395491021905	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
395491021906	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
395491021907	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
395491021908	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395491021909	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395491021910	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491021911	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395491021912	Walker A/P-loop; other site
395491021913	ATP binding site [chemical binding]; other site
395491021914	Q-loop/lid; other site
395491021915	ABC transporter signature motif; other site
395491021916	Walker B; other site
395491021917	D-loop; other site
395491021918	H-loop/switch region; other site
395491021919	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395491021920	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395491021921	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
395491021922	Walker A/P-loop; other site
395491021923	ATP binding site [chemical binding]; other site
395491021924	Q-loop/lid; other site
395491021925	ABC transporter signature motif; other site
395491021926	Walker B; other site
395491021927	D-loop; other site
395491021928	H-loop/switch region; other site
395491021929	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395491021930	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395491021931	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491021932	DNA binding site [nucleotide binding]
395491021933	domain linker motif; other site
395491021934	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
395491021935	ligand binding site [chemical binding]; other site
395491021936	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
395491021937	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491021938	putative substrate translocation pore; other site
395491021939	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
395491021940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395491021941	putative substrate translocation pore; other site
395491021942	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395491021943	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395491021944	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
395491021945	response regulator; Provisional; Region: PRK13435
395491021946	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395491021947	active site
395491021948	phosphorylation site [posttranslational modification]
395491021949	intermolecular recognition site; other site
395491021950	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395491021951	methionine sulfoxide reductase A; Provisional; Region: PRK13014
395491021952	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
395491021953	putative binding site; other site
395491021954	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
395491021955	MG2 domain; Region: A2M_N; pfam01835
395491021956	Alpha-2-macroglobulin family; Region: A2M; pfam00207
395491021957	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
395491021958	surface patch; other site
395491021959	thioester region; other site
395491021960	specificity defining residues; other site
395491021961	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
395491021962	Transglycosylase; Region: Transgly; pfam00912
395491021963	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
395491021964	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
395491021965	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
395491021966	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
395491021967	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
395491021968	active site
395491021969	catalytic site [active]
395491021970	YHS domain; Region: YHS; pfam04945
395491021971	YHS domain; Region: YHS; pfam04945
395491021972	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
395491021973	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395491021974	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395491021975	motif II; other site
395491021976	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
395491021977	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
395491021978	DNA binding residues [nucleotide binding]
395491021979	dimer interface [polypeptide binding]; other site
395491021980	copper binding site [ion binding]; other site
395491021981	RNA polymerase sigma factor; Provisional; Region: PRK12511
395491021982	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395491021983	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395491021984	DNA binding residues [nucleotide binding]
395491021985	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
395491021986	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
395491021987	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
395491021988	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
395491021989	Cytochrome C' Region: Cytochrom_C_2; pfam01322
395491021990	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
395491021991	dimerization interface [polypeptide binding]; other site
395491021992	Domain of unknown function (DUF305); Region: DUF305; cl17794
395491021993	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
395491021994	HTH DNA binding domain; Region: HTH_13; pfam11972
395491021995	replication initiation protein RepC; Provisional; Region: PRK13824
395491021996	Replication protein C N-terminal domain; Region: RP-C; pfam03428
395491021997	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
395491021998	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
395491021999	ParB-like nuclease domain; Region: ParBc; pfam02195
395491022000	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
395491022001	MerR family regulatory protein; Region: MerR; pfam00376
395491022002	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491022003	P-loop; other site
395491022004	Magnesium ion binding site [ion binding]; other site
395491022005	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395491022006	Magnesium ion binding site [ion binding]; other site
395491022007	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
395491022008	active site
395491022009	SAM binding site [chemical binding]; other site
395491022010	homodimer interface [polypeptide binding]; other site
395491022011	precorrin-3B synthase; Region: CobG; TIGR02435
395491022012	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395491022013	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395491022014	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
395491022015	Precorrin-8X methylmutase; Region: CbiC; pfam02570
395491022016	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
395491022017	active site
395491022018	SAM binding site [chemical binding]; other site
395491022019	homodimer interface [polypeptide binding]; other site
395491022020	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
395491022021	active site
395491022022	SAM binding site [chemical binding]; other site
395491022023	homodimer interface [polypeptide binding]; other site
395491022024	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
395491022025	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
395491022026	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
395491022027	active site
395491022028	putative homodimer interface [polypeptide binding]; other site
395491022029	SAM binding site [chemical binding]; other site
395491022030	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
395491022031	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395491022032	S-adenosylmethionine binding site [chemical binding]; other site
395491022033	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
395491022034	active site
395491022035	SAM binding site [chemical binding]; other site
395491022036	homodimer interface [polypeptide binding]; other site
395491022037	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
395491022038	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395491022039	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395491022040	DNA binding site [nucleotide binding]
395491022041	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
395491022042	putative ligand binding site [chemical binding]; other site
395491022043	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
395491022044	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
395491022045	putative di-iron ligands [ion binding]; other site
395491022046	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
395491022047	[2Fe-2S] cluster binding site [ion binding]; other site
395491022048	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
395491022049	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395491022050	Ketopantoate hydroxymethyltransferase [Coenzyme metabolism]; Region: PanB; COG0413
395491022051	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
395491022052	quinolinate synthetase; Provisional; Region: PRK09375
395491022053	L-aspartate oxidase; Provisional; Region: PRK07512
395491022054	L-aspartate oxidase; Provisional; Region: PRK06175
395491022055	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
395491022056	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
395491022057	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
395491022058	dimerization interface [polypeptide binding]; other site
395491022059	active site
395491022060	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
395491022061	Predicted integral membrane protein [Function unknown]; Region: COG5616
395491022062	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491022063	binding surface
395491022064	TPR motif; other site
395491022065	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395491022066	binding surface
395491022067	TPR repeat; Region: TPR_11; pfam13414
395491022068	TPR motif; other site
395491022069	Uncharacterized conserved protein [Function unknown]; Region: COG1944
395491022070	YcaO-like family; Region: YcaO; pfam02624
395491022071	TfuA-like protein; Region: TfuA; pfam07812
395491022072	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395491022073	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395491022074	non-specific DNA binding site [nucleotide binding]; other site
395491022075	salt bridge; other site
395491022076	sequence-specific DNA binding site [nucleotide binding]; other site
395491022077	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
395491022078	Amidohydrolase; Region: Amidohydro_2; pfam04909
395491022079	active site
395491022080	Transcriptional regulator [Transcription]; Region: IclR; COG1414
395491022081	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
395491022082	Bacterial transcriptional regulator; Region: IclR; pfam01614
395491022083	short chain dehydrogenase; Provisional; Region: PRK07063
395491022084	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
395491022085	NAD binding site [chemical binding]; other site
395491022086	homotetramer interface [polypeptide binding]; other site
395491022087	homodimer interface [polypeptide binding]; other site
395491022088	active site
395491022089	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
395491022090	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
395491022091	putative active site pocket [active]
395491022092	metal binding site [ion binding]; metal-binding site
395491022093	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
395491022094	Caspase domain; Region: Peptidase_C14; pfam00656
395491022095	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395491022096	Sel1-like repeats; Region: SEL1; smart00671
395491022097	Sel1-like repeats; Region: SEL1; smart00671
395491022098	Sel1-like repeats; Region: SEL1; smart00671
395491022099	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
395491022100	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
395491022101	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
395491022102	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395491022103	ligand binding site [chemical binding]; other site
395491022104	Caspase domain; Region: Peptidase_C14; pfam00656
395491022105	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
395491022106	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
395491022107	cleavage site
395491022108	active site
395491022109	substrate binding sites [chemical binding]; other site
395491022110	Caspase domain; Region: Peptidase_C14; pfam00656
395491022111	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
395491022112	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
395491022113	reactive center loop; other site
395491022114	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
395491022115	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
395491022116	active site
395491022117	substrate binding site [chemical binding]; other site
395491022118	activation loop (A-loop); other site
395491022119	Protein of unknown function (DUF982); Region: DUF982; pfam06169
395491022120	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
395491022121	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395491022122	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395491022123	phosphopeptide binding site; other site
395491022124	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
395491022125	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
395491022126	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
395491022127	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
395491022128	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
395491022129	phosphopeptide binding site; other site
395491022130	Type II/IV secretion system protein; Region: T2SE; pfam00437
395491022131	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
395491022132	ATP binding site [chemical binding]; other site
395491022133	Walker A motif; other site
395491022134	hexamer interface [polypeptide binding]; other site
395491022135	Walker B motif; other site
395491022136	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
395491022137	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
395491022138	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
395491022139	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
395491022140	Type II/IV secretion system protein; Region: T2SE; pfam00437
395491022141	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
395491022142	ATP binding site [chemical binding]; other site
395491022143	Walker A motif; other site
395491022144	hexamer interface [polypeptide binding]; other site
395491022145	Walker B motif; other site
395491022146	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
395491022147	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
395491022148	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
395491022149	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395491022150	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
395491022151	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
395491022152	hydroxyglutarate oxidase; Provisional; Region: PRK11728
395491022153	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395491022154	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
395491022155	conserved cys residue [active]
395491022156	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165